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<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IT62</accession>
    <name>A0A2H3IT62_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WOLCODRAFT_21811</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6 7">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
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    </dbReference>
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        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="KR_dom"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF133">
        <property type="entry name" value="3-OXOACYL-[ACYL-CARRIER-PROTEIN] REDUCTASE"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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            <begin position="24"/>
            <end position="196"/>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PCH33176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="286" mass="29611" checksum="63EAE654B0BE80BE" modified="2018-01-31" version="1">MAERLTQVSGHLTNTYGRGLLAGEVAIITGAAQGIGRSAALLFAKEGAKVVVTDLDEKKAQVVVDEITKAGGDALAVGGDVSADDFPQKVIEATIKKYGKINHIVNNAGFTYDRMLHTTPDDAFDIILKVHVRAPFRLVRAAAPHMRIKGNTENRSIVNVSSVSGLHGSVGQINYAAAKSAVVGMTKTICKEWGSFNVRANTVAFGFVQTRLTAAKEDGATIEIDGKKVALGIPKAQAGVAGPGAVIPLGRGATPDEAAAGILFLASPLASYVSGHTLEVTGGQGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IUE6</accession>
    <name>A0A2H3IUE6_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WOLCODRAFT_135212</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH33606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="742152.A0A2H3IUE6"/>
    <dbReference type="OMA" id="QMVIFAY"/>
    <dbReference type="OrthoDB" id="10062876at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000006">
        <property type="entry name" value="General amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF20">
        <property type="entry name" value="AAT FAMILY AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
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    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
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    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
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        <location>
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            <end position="68"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="80"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="378"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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            <end position="432"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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            <end position="474"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="480"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="49"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
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            <begin position="1"/>
            <end position="13"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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            <dbReference type="SAM" id="Phobius"/>
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            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH33606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="547" mass="59560" checksum="21919297E7137231" modified="2018-01-31" version="1"> </sequence>
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<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
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    <name>A0A2H3IUR9_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WOLCODRAFT_147807</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
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                <person name="Gaskell J."/>
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                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001193">
        <property type="entry name" value="Rab family, other"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PCH33681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="242" mass="26793" checksum="56FDE5F5C70E3E47" modified="2018-01-31" version="1">MPVDDYEADATELMETYDFLMKYIVIGEAGTGKSCLLHQFTHNSFKDHSQHTIGVEFSSRTIKLGEKRIKLQLWDTAGQERFRSVTRSYYRGAAGAILVYDITSRASFTNLAQWLADARALASPYLVTVLVGNKSDREEDREVEWAEASKWAAENDLHFLEASSLSGDNVEAPFLLCTRAILLSIESGILDPEKAGSGVSYGDRALRRVNSSSRLSFGSLSGNRRKSGTIKLRLPGPGKKCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IWQ5</accession>
    <name>A0A2H3IWQ5_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FMN-linked oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_87460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH34386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3IWQ5"/>
    <dbReference type="STRING" id="742152.A0A2H3IWQ5"/>
    <dbReference type="OMA" id="CRTRNQR"/>
    <dbReference type="OrthoDB" id="10262250at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017150">
        <property type="term" value="F:tRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052582">
        <property type="entry name" value="tRNA-DUS-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45936">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(20) SYNTHASE [NAD(P)+]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45936:SF1">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(20) SYNTHASE [NAD(P)+]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUS-like FMN-binding" evidence="2">
        <location>
            <begin position="93"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH34386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="456" mass="49472" checksum="2BDA389369E12EB1" modified="2018-01-31" version="1">MSQRRSHSPFASHRAAKRQKLDFEPLTPEDYKNGIVLAPMVRSGALPTRLYALKHGASLVWGPETVDKAILHTTREVDPVTGVVSYVGKSKAIFTTHPIEKPYLIYQIGSADPEIAVQAAKAVMQDVAGFDLNCGCPKPFSTHAGMGAALLSNPDLLCSILTALRQAMPPEISVSAKIRLLPSQEDTLKLVERIINTGVSALTVHCRTRNQRKREPALIERLREIVEFVEGMGRGVAVIENGDCEGFEDGLRIRRTTGAHSVMIATAAESNPTCFSPTPLVDLEQTFIPQYIRLCKYLNNHWSSTKFCTSQFKGPHVNTSRADTKVFHEAIMHAKGYDDIASRVKPWTGEEEFKAIVATIESRHGRIAPLKLPEQESESAIASKALTPEVQKNGEAGIEKQDELVTPPTGEPDPAVMNAPLGPANEACVPMPAMLTGDLPTPTPAPVSGATVVPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IXH5</accession>
    <name>A0A2H3IXH5_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Coatomer subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Beta-coat protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">WOLCODRAFT_22488</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Golgi apparatus membrane</location>
            <topology evidence="1 10">Peripheral membrane protein</topology>
            <orientation evidence="1 10">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Cytoplasmic vesicle</location>
            <location evidence="10">COPI-coated vesicle membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
            <orientation evidence="10">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH34145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3IXH5"/>
    <dbReference type="STRING" id="742152.A0A2H3IXH5"/>
    <dbReference type="OMA" id="IYKNFDW"/>
    <dbReference type="OrthoDB" id="10261439at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000451">
        <property type="entry name" value="Coatomer subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011710">
        <property type="entry name" value="Coatomer_bsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016460">
        <property type="entry name" value="COPB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029446">
        <property type="entry name" value="COPB1_appendage_platform_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10635">
        <property type="entry name" value="COATOMER SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10635:SF0">
        <property type="entry name" value="COATOMER SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07718">
        <property type="entry name" value="Coatamer_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14806">
        <property type="entry name" value="Coatomer_b_Cpla"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005727">
        <property type="entry name" value="Coatomer_beta_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ARM repeat"/>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">MD-104</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467832">
        <property type="protein sequence ID" value="PCH34876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3IY36"/>
    <dbReference type="STRING" id="742152.A0A2H3IY36"/>
    <dbReference type="OMA" id="RWPMAEL"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="381"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PCH34876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="426" mass="48143" checksum="5D0554E9269BE91E" modified="2018-01-31" version="1" fragment="single">EAYYTWSSLIHIGAVVSLPVFGQDVIIVNSIEAATELLDARRNFACRPRWPMADLLGRQRSVGFHRYGERLKKLRKILHASLSSSVVTSTWSARLEAQSISLCKALLCNQQTVNVVVEDNMQDHIINYIYGRRPTPEYTQLLKQVMHETGVALQPGRWLVNFIPALAWIPAWTPGAAFQRWAREARESLVALTHQPFHRVQVDMLDGVSTSSFVKRSLESLSNPSSVEDREIVMDAAGSFMTAGIDTLVSIIQTFLAIMVRHEAVQNRAYQEIIEVVGTHRLPGLEHRGSLPYVDAVIQEVFRFNPPIPLLSRSNIEEDGYDGYRIPQRSWILGNLWGILHDETRYPDADQFVPERFIPSDGTSKPLDPRSIVFGFGRRRCPGVHFAEMLVYLIVARLLRLCVFSPEVQDGTIVLPPIDFMTSLVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IYF5</accession>
    <name>A0A2H3IYF5_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Metallo-hydrolase/oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WOLCODRAFT_139690</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-beta-lactamase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB467843">
        <property type="protein sequence ID" value="PCH35012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3IYF5"/>
    <dbReference type="STRING" id="742152.A0A2H3IYF5"/>
    <dbReference type="OMA" id="CPGSAWE"/>
    <dbReference type="OrthoDB" id="10250730at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07730">
        <property type="entry name" value="metallo-hydrolase-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051013">
        <property type="entry name" value="MBL_superfamily_lactonases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978:SF5">
        <property type="entry name" value="METALLO-BETA-LACTAMASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978">
        <property type="entry name" value="QUORUM-QUENCHING LACTONASE YTNP-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="5">
        <location>
            <begin position="43"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PCH35012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="296" mass="33290" checksum="81A5EDAEB9FF1F1B" modified="2018-01-31" version="1">MLTPDIEGQKYVLVYALHAGSFYLPDKEVFEDSLEAKTGSQVPSFAFLIEHDVHGRLMFDPGLRKHGQGYPPAWEETLQEFTVDCPRDVVDLLEEGGVSPSSIRTVVYSHLHFDHVGDLAPFTSAEVILGGEAAELMEDTYPRNPDSLWQEFPAGHKVCYIDFETDQRGLSPLGSFNRAVDFFRDGSLYLLDAPGHFPGHLAALARVSTNKFVLLAADCCHNRLCYNPGHRLISRENYHDVQVARDTVQRLKIMDRTEGVLVILAHERERLDEMPLFPNSLNHRAQTQIGKKTNAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IZA1</accession>
    <name>A0A2H3IZA1_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ribophorin II</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Ribophorin-2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">WOLCODRAFT_125694</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SWP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467843">
        <property type="protein sequence ID" value="PCH35276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3IZA1"/>
    <dbReference type="STRING" id="742152.A0A2H3IZA1"/>
    <dbReference type="OMA" id="VFFMYYT"/>
    <dbReference type="OrthoDB" id="432292at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055374">
        <property type="entry name" value="Ribophorin_II_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056790">
        <property type="entry name" value="Ribophorin_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008814">
        <property type="entry name" value="Swp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12640:SF0">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12640">
        <property type="entry name" value="RIBOPHORIN II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23860">
        <property type="entry name" value="Ribophorin_II_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25147">
        <property type="entry name" value="Ribophorin_II_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0732">Signal</keyword>
    <keyword evidence="16" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044345388" description="Ribophorin II" evidence="13">
        <location>
            <begin position="19"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Ribophorin II third" evidence="14">
        <location>
            <begin position="36"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="Ribophorin II C-terminal" evidence="15">
        <location>
            <begin position="175"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF23860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF25147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PCH35276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="276" mass="30467" checksum="64FD072183C0E5C9" modified="2018-01-31" version="1">MVRLWLTLTLLAAAGAHAASLTVQTPRFTISGPDATQLRSESISLDQSARPTLTLGTTDVLKLTFQVSESSEGKGVQPHQTFLRFYDEVSGEEGVQPVRVTPGGKAKFELNMARPPVYLPPTTTNPLIVTLMLGSFEYAPVQHDLFNLVLPASQPPPQHPDETRFAPLPEITHTFRPEQRTPAKAASAFFAAFVYWPWLILIGLWLYINPRVPHLFSPHVFPFIASLGAFEGLLLWYWVSLKLGQVLLYGGILGVLTALAGKRALSKTGEWRVGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J034</accession>
    <name>A0A2H3J034_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_147245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH33143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J034"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="173"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH33143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="379" mass="40725" checksum="816DE96CC55D1CB1" modified="2018-01-31" version="1">MAQRGGAAVSAHLRLTVRTSTSPQEAMAPVSNTTSRQRPPAGQRANPTPKAQPRRYSDSDQARIMGKDEDLTAPTASPAPPECPIARTMRKRRARARQRVTPKQVDAPNVQPHRSNSGAAALPNAPPLPPAAPDMGAQSGRAARQRVGRGADTVKTPPYARPRDRTPPERRTGTSSSSTCGRTRSGKPIRHSRSPSTVEANRPDSEHADIPSGRRSTSQRQPPPLTLPPPRQAMPRIQRTPRPRRPAAVKRGETPPTDKGPSSPVHRLPSGHRQTVGLPTCKKAGTTGTQRHRVDHKKLETSEGGATGSLGSAPTYKADTPVDTPPPTRNHQQQRPLGRGPPTLIAAASVTVDQDKQLVTAIRRILQARTQVLTTEPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J0M0</accession>
    <name>A0A2H3J0M0_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase family 8 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_133984</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467854">
        <property type="protein sequence ID" value="PCH35800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J0M0"/>
    <dbReference type="STRING" id="742152.A0A2H3J0M0"/>
    <dbReference type="OMA" id="YQNINAN"/>
    <dbReference type="OrthoDB" id="2014201at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002495">
        <property type="entry name" value="Glyco_trans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050587">
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        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
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        <property type="entry name" value="GLYCOGENIN SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01501">
        <property type="entry name" value="Glyco_transf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH35800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="369" mass="41433" checksum="0EA65DAF148B8412" modified="2018-01-31" version="1">MSFFSRYKDYAPLRSDASTTKSNSRKYTLLLTVALIAASGILNVVLYSKLSKRWPVPLDNYQHLNVQPIVNEEFLSTIGPLDPSENAIVTSLYTDSYATAIATLGHSLNRVNSSAGRILFYLPEKVSPRALCIATSSGFVPHAIERIPPPHGGRGVYAHFLDQYSKLQLWTLADRGIKGVVYLDADTLVMSNFDELFALPYGFAAVPDVYVDEQGFALAFNAGVLFVRPSRAVFDDMLAKIATASYNAHEAEQSFLNHYFGAEALRLPYVYNANLAIKMRKPELWEDVRREARIMHYTLVKPFLAEMDNSGKTVVEMRGMEANVQNKMSQYGGKFEDELKDWVEIWRETRRTYADAFTQCSSKSASLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J3S5</accession>
    <name>A0A2H3J3S5_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_28781</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:pentose-phosphate shunt, non-oxidative branch"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
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</entry>
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    <name>A0A2H3J4V0_WOLCO</name>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J4V0"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH37260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="66" mass="7317" checksum="589E348C077D7132" modified="2018-01-31" version="1">MPKSIPKVLNTVNPSSRTTKSEEERTPNDDSRVPYIGSPQSESPAKRDEEGMDEAGRRTQSERKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J503</accession>
    <name>A0A2H3J503_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467832">
        <property type="protein sequence ID" value="PCH34863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J503"/>
    <dbReference type="OMA" id="EMRTYHE"/>
    <dbReference type="OrthoDB" id="3263163at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="417"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="482"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="618"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="257"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="422"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="489"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="506"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="618"/>
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        <lineage>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
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                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
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                <person name="Benoit I."/>
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                <person name="Kallen N."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1221748"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
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                <person name="Martinez A.T."/>
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                <person name="Yadav J.S."/>
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    <dbReference type="Pfam" id="PF00013">
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    </evidence>
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    </evidence>
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</entry>
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                <person name="Ohm R.A."/>
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                <person name="Sabat G."/>
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                <person name="St John F."/>
                <person name="Stenlid J."/>
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                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
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            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH34349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J6I5"/>
    <dbReference type="STRING" id="742152.A0A2H3J6I5"/>
    <dbReference type="OMA" id="SKTKWHF"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12122">
        <property type="entry name" value="AMPKA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14334">
        <property type="entry name" value="UBA_SNF1_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000407">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000003">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.80">
        <property type="entry name" value="Kinase associated domain 1, KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032270">
        <property type="entry name" value="AMPK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028375">
        <property type="entry name" value="KA1/Ssp2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013896">
        <property type="entry name" value="SNF1_UBA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF110">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16579">
        <property type="entry name" value="AdenylateSensor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08587">
        <property type="entry name" value="UBA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103243">
        <property type="entry name" value="KA1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="16"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PCH34349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="635" mass="71795" checksum="D243B3501E3ECAE7" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J804</accession>
    <name>A0A2H3J804_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Nucleoside diphosphate kinase</fullName>
            <ecNumber evidence="3 11">2.7.4.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WOLCODRAFT_23309</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:44640"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 10">Belongs to the NDK family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.6" evidence="3 11"/>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH38360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J804"/>
    <dbReference type="STRING" id="742152.A0A2H3J804"/>
    <dbReference type="OMA" id="QHYGEHK"/>
    <dbReference type="OrthoDB" id="2162449at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006241">
        <property type="term" value="P:CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006228">
        <property type="term" value="P:UTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04413">
        <property type="entry name" value="NDPk_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.141:FF:000002">
        <property type="entry name" value="Nucleoside diphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="entry name" value="Nucleoside diphosphate kinase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00451">
        <property type="entry name" value="NDP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034907">
        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001564">
        <property type="entry name" value="Nucleoside_diP_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023005">
        <property type="entry name" value="Nucleoside_diP_kinase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001908">
        <property type="entry name" value="PRK00668.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11349">
        <property type="entry name" value="NUCLEOSIDE DIPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01243">
        <property type="entry name" value="NUCDPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="Nucleoside diphosphate kinase, NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00469">
        <property type="entry name" value="NDPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51374">
        <property type="entry name" value="NDPK_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 11 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleoside diphosphate kinase-like" evidence="12">
        <location>
            <begin position="5"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="active site" description="Pros-phosphohistidine intermediate" evidence="9">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PCH38360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="152" mass="16782" checksum="DB23A79D8D0A93E7" modified="2018-01-31" version="1">MVNIQERTYIMVKPDGVQRGIVGNIIGRFEQRGFKLVALKLVHATPEHLEKHYADLKGKPFFPGLITYMASGPVVAMVWEGLDAVKTGRVMLGATNPLASAPGTIRGDFALAVGRNICHGSDSVENAEKEINLWFPEGIVQYTNDQAKWIFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J8H5</accession>
    <name>A0A2H3J8H5_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_139698</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467843">
        <property type="protein sequence ID" value="PCH35039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J8H5"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH35039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="96" mass="10836" checksum="AF15C1ADE5A94374" modified="2018-01-31" version="1" fragment="single">MGPSVGPRWSDRRHRPSDPLRSCDALVLVTGATIALSRRITRSCESNESHAQQLESTMQHGRARDATYPPDGALRIDLHHSRTFLGHRFIFFLLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J8H9</accession>
    <name>A0A2H3J8H9_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_148013</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH33948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J8H9"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH33948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="69" mass="7598" checksum="41EB838FC6D35F6A" modified="2018-01-31" version="1">MSVLLWQQTPQLRQSSAISGDLEGSETAAVPLRNMNVPPSNLSEHLCRRSHDAGKKRVGKRRIGMTGKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J935</accession>
    <name>A0A2H3J935_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WOLCODRAFT_66332</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH38772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J935"/>
    <dbReference type="STRING" id="742152.A0A2H3J935"/>
    <dbReference type="OMA" id="WHWAAGW"/>
    <dbReference type="OrthoDB" id="10249920at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047631">
        <property type="term" value="F:ADP-ribose diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006753">
        <property type="term" value="P:nucleoside phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019693">
        <property type="term" value="P:ribose phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18888">
        <property type="entry name" value="NUDIX_ADPRase_Nudt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000016">
        <property type="entry name" value="ADP-sugar pyrophosphatase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11839:SF1">
        <property type="entry name" value="ADP-SUGAR PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11839">
        <property type="entry name" value="UDP/ADP-SUGAR PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="3">
        <location>
            <begin position="49"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PCH38772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="208" mass="23086" checksum="C126B87220143802" modified="2018-01-31" version="1">MSQAPKILSVEELPTSEAKWVTLKKIHWSDPEGKQRTWECAERTTRGSSGIDAVAILAILRSESNAFRPSTVIVEQFRAPVGKFVVELPAGLIDEGETAEDAAIRELEEETGFKAKRVLESSPLQVCDPGMTTANMKLVAVDVPFPDQLEVSEQKLDAGEFITTRIVELPKLAAELKEYEKKGYVVDARLSHFASGYEMAEKLRNMSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J9Q0</accession>
    <name>A0A2H3J9Q0_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_157236</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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            <dbReference type="EMBL" id="PCH36523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="215" mass="24820" checksum="BE39E2B8AC80D12D" modified="2018-01-31" version="1">MPRAARFTVKPKNAASGVREEWDICSTQALEDRISNVVAPRAKKSRKGNAAKRVEEERAAWTLQQRIAKPPAKSLLDRVEELRMPAEWVEARGLSNPKDVHCTEKKWDWFLEIQKKMVNAHPAIYQLARADNYLSPPAILTRFTLLTTDFDDLCANLEHRVRQDKMQNKEMRLLEKYLKQMEHIFGDLEVDKHTTQEMVIARGHASKAKNTSSEE</sequence>
</entry>
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            <taxon>Phaeolaceae</taxon>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JAA6"/>
    <dbReference type="Proteomes" id="UP000218811">
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH34608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="256" mass="28352" checksum="3C53CE056C4B4215" modified="2018-01-31" version="1">MCNLRNGRFDADNVRVDVHSVVRLRFHSHFLHAPLVIFGAFRKVDSQSLFGSRRAAYEQTGESLKRSQSNRAKPEKASYYCADVRIYETRLRRERMEGGKIIISCSNAVEFARRGVQSDFDNVLSRKPRICCPRTTNTLAASRSPLLPSRSDTPHLHSARRTRLCAQSPSGFQSRIITAIHAQVGDARASLWHGPSGGLLFVTARLDAAPPAVVDPRSSPRHGQRADDACEIDAPVRMGLLQQFVLPPAALVLSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
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    <name>A0A2H3JAN8_WOLCO</name>
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            <fullName evidence="15">WH1-domain-containing protein</fullName>
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        <name evidence="15" type="ORF">WOLCODRAFT_158501</name>
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    <organism evidence="15 16">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CDC42SE/SPEC family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467943">
        <property type="protein sequence ID" value="PCH38971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="742152.A0A2H3JAN8"/>
    <dbReference type="OMA" id="WEHEFYE"/>
    <dbReference type="OrthoDB" id="8963340at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0071933">
        <property type="term" value="F:Arp2/3 complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="F:cytoskeletal protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035023">
        <property type="term" value="P:regulation of Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EVH1_WASP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000281">
        <property type="entry name" value="Actin associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.810.10:FF:000010">
        <property type="entry name" value="Related to Neural Wiskott-Aldrich syndrome protein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CRIB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036936">
        <property type="entry name" value="CRIB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
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    <dbReference type="InterPro" id="IPR039056">
        <property type="entry name" value="SPEC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011026">
        <property type="entry name" value="WAS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033927">
        <property type="entry name" value="WASPfam_EVH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000697">
        <property type="entry name" value="WH1/EVH1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13502">
        <property type="entry name" value="CDC42 SMALL EFFECTOR PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13502:SF9">
        <property type="entry name" value="CRIB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00786">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00568">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00461">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47912">
        <property type="entry name" value="Wiscott-Aldrich syndrome protein, WASP, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50229">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0564">Palmitate</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WH1" evidence="14">
        <location>
            <begin position="19"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="CRIB" evidence="13">
        <location>
            <begin position="153"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="121"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="212"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="137"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="229"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="251"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PCH38971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="260" mass="28251" checksum="2CB22E898A289CE3" modified="2018-01-31" version="1" fragment="single">MPSTSTLNNDEKSKVKAAIPTASNKIHTAALARIYYAHPQPSEWSYAGLQGALALVHDKSKNSLFMRMVDLAGTRGVIWQHELYEGFEYFQDRPFFHSFAGDKCMIGVVFADEGEAKTFHKKVTTTKPGTEKPKASSSKKKTAKRGKIDKSMISGPTSGSFKHVAHMGYDSNSGFTSSNVDPSWSAFLKELEGRGISQDMLQENMEFIKDFVRDAQKAPPAPAAPASGGKKRPPPPPASRRHGHQDSVSAPTPPPAPPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JBF8</accession>
    <name>A0A2H3JBF8_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Histone chaperone domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WOLCODRAFT_140208</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Forms a chaperone-bound H2A.Z-H2B complex that acts as a source for SWR1 complex-dependent H2A to H2A.Z histone replacement in chromatin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CHZ1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467865">
        <property type="protein sequence ID" value="PCH36069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JBF8"/>
    <dbReference type="STRING" id="742152.A0A2H3JBF8"/>
    <dbReference type="OMA" id="MEGVQDP"/>
    <dbReference type="OrthoDB" id="3364766at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019098">
        <property type="entry name" value="Histone_chaperone_domain_CHZ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09649">
        <property type="entry name" value="CHZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01082">
        <property type="entry name" value="CHZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histone chaperone" evidence="7">
        <location>
            <begin position="59"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="92"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="37"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="111"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PCH36069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="121" mass="13076" checksum="B086B42B462B3E7C" modified="2018-01-31" version="1">MSTNAAAANGSSATHAADARTDAPVVDKGKGKFVQEEIMDDDEDDDEEEEEEEEDDDDDMAEDDLEEIDPSAIIGTRRTRGVRVDYTSAAALQKAGLQPSSADDEEGEDSFVAKDDEMNDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JBY2</accession>
    <name>A0A2H3JBY2_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_53261</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467988">
        <property type="protein sequence ID" value="PCH39411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JBY2"/>
    <dbReference type="OrthoDB" id="3209382at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH39411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="211" mass="23390" checksum="CDF772EB5E691871" modified="2018-01-31" version="1" fragment="single">LHHIAAILPIPLLLRHISTNAAIRIHTLPTSAQIRTRLPPPWPLPRNQTAPYPLSDTIVRRSRRPLTIVHHLASLIPVDAETTDPYYTAPWDRQHGWGERLQADVPDSRLTKDQCKAYINGLQTTLARGRMDPSTLFIFTDRSRRRAGRPHRLTGAGYAAYLAGAEVRSSQLGLGRKASIYDAELLALAAAAFALPALLACHPTVCTVYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JC18</accession>
    <name>A0A2H3JC18_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_168135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467963">
        <property type="protein sequence ID" value="PCH39125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JC18"/>
    <dbReference type="STRING" id="742152.A0A2H3JC18"/>
    <dbReference type="OMA" id="SDICFES"/>
    <dbReference type="OrthoDB" id="2792799at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH39125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="232" mass="25662" checksum="49F64B7702AD8293" modified="2018-01-31" version="1">MDCHSFQAEWNAHPISGPDTNDRSPNDLRLLGQLNHGVYTDDGIDLHPDVLHEHYGTTNQQVRRRRGQTGAGHPPEEDDNSDASNSDSETDSDLGITTQVAATQHSNIRHAAIPVPSNSNPFESEDSEALYFDALDLIRLEGTIPAGFGALPIEHAYEVEEVIRLGRRGRKELVVGLPEHIWRPRIELWAQAVHLLNEFMDAGAGSIVSVLPLEGSLAYSDRHRRPVFEAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JCR8</accession>
    <name>A0A2H3JCR8_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_158946</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467987">
        <property type="protein sequence ID" value="PCH39375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JCR8"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH39375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="234" mass="26632" checksum="1EE412E83566FCB1" modified="2018-01-31" version="1">MHPTTAFIEEEEDDFGYTTAIDLPEYDWTLRRKPFAGAGGDELPPLDNLNINDNAGGMDDQQPPTQTHITTPPPINPTREPVKPERVRMTFDDDEYPSRPTSPSFRTKVGIYAEALAKLRYWDDECCSDYIHGAVGLQHKVREEERRKAEQLDQLNDDSDSPELTKRMPDKPAPAPQPSPRTHSSYHLLKQGQPAYDGEFNLLNLQEVRHVPPKWQIPQVSDKCRETFTPIPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JD52</accession>
    <name>A0A2H3JD52_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_159083</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467998">
        <property type="protein sequence ID" value="PCH39495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JD52"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH39495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="136" mass="14634" checksum="6C20638181F101E1" modified="2018-01-31" version="1">MLRVTNRAPHPLIDPKDDPACQKRPPAAPPCLTNRTVPLPDGAASAKCQNIGNAPSWETANPRAPDQDSQDAKANHRPKGNCSPNAHPAGHLRQRRRPNRSTVTHSGRPHGKGNHPSHTDTAACHNVTRNTGSIQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JD70</accession>
    <name>A0A2H3JD70_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">thioredoxin-dependent peroxiredoxin</fullName>
            <ecNumber evidence="1">1.11.1.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Thioredoxin peroxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WOLCODRAFT_136685</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peroxiredoxin family. BCP/PrxQ subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.24" evidence="1"/>
    <dbReference type="EMBL" id="KB468053">
        <property type="protein sequence ID" value="PCH40146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JD70"/>
    <dbReference type="STRING" id="742152.A0A2H3JD70"/>
    <dbReference type="OMA" id="MNTHADR"/>
    <dbReference type="OrthoDB" id="338622at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03017">
        <property type="entry name" value="PRX_BCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050924">
        <property type="entry name" value="Peroxiredoxin_BCP/PrxQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42801:SF4">
        <property type="entry name" value="AHPC_TSA FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42801">
        <property type="entry name" value="THIOREDOXIN-DEPENDENT PEROXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="6" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="11">
        <location>
            <begin position="44"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="199"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="211"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PCH40146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="225" mass="24269" checksum="91F0285F0C581480" modified="2018-01-31" version="1">MALYNRRKPSWSVVLSSYGNHRVLLSSSAAPAPIAPAPTTMPHLLVGKPAPSLSLPDANGETYSLSPGAKEVPTALFFYPESGTYGCTKEACQFRDALAEKELYKCTKVEIVGISKDSVEKQKAFVEKEKLTYPILSDANGEARKAYHVGKSLMGLTDARVTFFIDSKGVIRDVLDTTINYGAHAKFVTKWLDKVEAENRKTAKPAEEAEIPSAASASAGEPAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JD98</accession>
    <name>A0A2H3JD98_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">SNF2 family DNA-dependent ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WOLCODRAFT_135395</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH33927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JD98"/>
    <dbReference type="STRING" id="742152.A0A2H3JD98"/>
    <dbReference type="OMA" id="VNWEDQF"/>
    <dbReference type="OrthoDB" id="448448at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF52">
        <property type="entry name" value="SINGLE-STRANDED DNA-DEPENDENT ATPASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013554480" description="SNF2 family DNA-dependent ATPase domain-containing protein" evidence="6">
        <location>
            <begin position="21"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="272"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="971"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="344"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="440"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="514"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="811"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="355"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="440"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="459"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="518"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="814"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="840"/>
            <end position="849"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PCH33927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1131" mass="124450" checksum="8E072A95A203C86B" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JDC1</accession>
    <name>A0A2H3JDC1_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_67930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468053">
        <property type="protein sequence ID" value="PCH39881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JDC1"/>
    <dbReference type="STRING" id="742152.A0A2H3JDC1"/>
    <dbReference type="OMA" id="SWHANAG"/>
    <dbReference type="OrthoDB" id="3224221at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH39881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="263" mass="31256" checksum="FFC7F98FB252A352" modified="2018-01-31" version="1">MRRDNNKSPIDIQIVPSRREVEEWTNRSDCEKRECCAADEFQLDLESTVTTDWNRSATKIFVKDFIASGEYDCTDRKAVERAFKSHFNTLRRHWNQSQLTRERIEDQKAQHSHDTRKRNVSCPLLFQRRLHVAVSTEQLRHHVSMLQYLGVDSMSSDEPDTHNGLKQYRILCKKWRHPAMGPWLQAFDAVYRQTKHIASESQRGTQPRTRFLSNREDNMRPPVKRLPRNAYNPEWYNELNVIDRDNLEAGPDYDFTHLPDIMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JDK5</accession>
    <name>A0A2H3JDK5_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_168147</name>
    </gene>
    <organism evidence="1 2">
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
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                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
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                <person name="Sabat G."/>
                <person name="Salamov A."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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        <source>
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    </evidence>
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                <person name="Ferreira P."/>
                <person name="Findley K."/>
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                <person name="Heitman J."/>
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                <person name="Hori C."/>
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                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
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                <person name="Sabat G."/>
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                <person name="Wiebenga A."/>
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                <person name="Eastwood D.C."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Barry K."/>
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                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
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                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
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                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
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                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
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                <person name="Syed K."/>
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                <person name="Wiebenga A."/>
                <person name="Young D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD-104</strain>
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    </evidence>
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            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Morgenstern I."/>
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                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
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                <person name="Young D."/>
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                <person name="Eastwood D.C."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH40702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JEM9"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21037">
        <property type="entry name" value="MLKL_NTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.20">
        <property type="entry name" value="Adaptor protein Cbl, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036537">
        <property type="entry name" value="Adaptor_Cbl_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059179">
        <property type="entry name" value="MLKL-like_MCAfunc"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH40702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="258" mass="28643" checksum="D51D71D76025734B" modified="2018-01-31" version="1">MASVMTLSKRNRVNVALLKITLALKDLQQASRVLQDVPRLPDLVGIAYDIVIAVQDVQSNKKVTISIAQRVGEFAKQIYKEATTKREVTFDMAALDACLVVIQEDLVEMLDKLKKQISNGSLKRWKNRTNTKGILEGCIKQISEAQHAFELDMVSLCTQIDTDRQDEPSLEPPSESLLLPPSEQPTEEEAPEYEPKQPEDVMPPLSELVYAGFGTAPKDGGHVMFMKIPSLKRRTGILVVVLPSVLALIAATGRYFAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JEZ4</accession>
    <name>A0A2H3JEZ4_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WOLCODRAFT_23844</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">PML body</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB468053">
        <property type="protein sequence ID" value="PCH40105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JEZ4"/>
    <dbReference type="STRING" id="742152.A0A2H3JEZ4"/>
    <dbReference type="OMA" id="HNPICDQ"/>
    <dbReference type="OrthoDB" id="1305878at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040909">
        <property type="entry name" value="CHFR_Znf-CRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052256">
        <property type="entry name" value="E3_ubiquitin-ligase_CHFR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16079:SF4">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE CHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16079">
        <property type="entry name" value="UBIQUITIN LIGASE PROTEIN CHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17979">
        <property type="entry name" value="zf-CRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="74"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PCH40105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="485" mass="53235" checksum="ED53534AF889BEB2" modified="2018-01-31" version="1">MDETATHDVSQSLAAITLKRRASLSFEGMQDDECRKRLKEDHEASRQDACAHPGSVTAVDGEALANDLEQELQCACCSALVYRPVIVAPCQHFFCGSCVVMWIRNGGTNCPACRSTSAVVTPSRALQTMVEILLRAAPSKIRPENERIQADEIYRAGMSLRIPSPRPASPEPTIHQRNASFVHPCPHCHAGNPLGWRCPQPIVDPEVDPDHAWHTEDGSPPGHAYCGNCENILSLQAPSTTKCDFCQVSFCGIAIPGRCVAAPLIAQQPHGLSDLGDLIQCGEIYDCFDGNTVEVDIMLDYLTAQRLTPRHIYREIVMHIQSQPRQFAPLMELELFVDVHSVSGGIDPDPSAPRNSICRVCATEVFLWGLRDWWVRERKKGFLEESVTKRPDCPEGSGCDRQKDHSHAKEFNHVISSLDDSETFLGVAPQSAPQAEVGSSSSLASAQGRMLPSLRSADVFAMLRLSGVASDPLSQEFRDEVESLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JFH9</accession>
    <name>A0A2H3JFH9_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Small GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WOLCODRAFT_142624</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endomembrane system</location>
            <topology evidence="5">Lipid-anchor</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH38563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JFH9"/>
    <dbReference type="STRING" id="742152.A0A2H3JFH9"/>
    <dbReference type="OMA" id="NVKGWIT"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01869">
        <property type="entry name" value="Rab1_Ypt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001447">
        <property type="entry name" value="Ras-related protein Rab-1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057289">
        <property type="entry name" value="Rab1/Ypt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050305">
        <property type="entry name" value="Small_GTPase_Rab"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47980">
        <property type="entry name" value="LD44762P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
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</entry>
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            <taxon>Agaricomycetes</taxon>
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            <taxon>Phaeolaceae</taxon>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
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                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7 8">MD-104</strain>
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        <subcellularLocation>
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        <source>
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        </source>
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</entry>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
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                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
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                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
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                <person name="Kohler A."/>
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                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
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                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
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            <dbReference type="DOI" id="10.1126/science.1221748"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10 11">MD-104</strain>
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        <text evidence="7">Homotrimer. Homotrimerization increases the affinity of HSF1 to DNA. Interacts with transcriptional coregulator SSA1 on chromatin.</text>
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        <property type="entry name" value="WH_DNA-bd_sf"/>
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        <property type="entry name" value="HEAT SHOCK FACTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <location>
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        <source>
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        <source>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
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    </evidence>
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        <source>
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        <source>
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    </evidence>
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        <source>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PCH36448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="100" mass="11676" checksum="06CEE502CDF6359E" modified="2018-01-31" version="1" fragment="single">MINDPKSAQFINWTDLGTSFVVSNVGEFSRTILGSHFKHNNFSSFVRQLNMYGFHKINRTPRAQRTSADVQTWEFSHHKFLRGRPDLLEEIKRKALEPDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JFQ7</accession>
    <name>A0A2H3JFQ7_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">60S ribosomal protein L5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WOLCODRAFT_24436</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL18 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH41030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JFQ7"/>
    <dbReference type="STRING" id="742152.A0A2H3JFQ7"/>
    <dbReference type="OMA" id="CQIASAH"/>
    <dbReference type="OrthoDB" id="1618453at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00432">
        <property type="entry name" value="Ribosomal_L18_L5e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.100:FF:000002">
        <property type="entry name" value="60S ribosomal protein L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01337_A">
        <property type="entry name" value="Ribosomal_uL18_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005485">
        <property type="entry name" value="Rbsml_uL18_euk_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057268">
        <property type="entry name" value="Ribosomal_L18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025607">
        <property type="entry name" value="Ribosomal_uL18_C_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23410:SF12">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23410">
        <property type="entry name" value="RIBOSOMAL PROTEIN L5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14204">
        <property type="entry name" value="Ribosomal_L18_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17144">
        <property type="entry name" value="Ribosomal_L5e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00058">
        <property type="entry name" value="RIBOSOMALL5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL18 C-terminal eukaryotes" evidence="6">
        <location>
            <begin position="238"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PCH41030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="309" mass="35383" checksum="0F5E0A878066B7D2" modified="2018-01-31" version="1">MPFVKKVKSDAYFSRFQVKYRRRREGKTDYYARKRLVTQAKNKYNAPKYRLVVRFTNKEVIVQIIYARLQGDFVLCAARSKELPRYGINHGLTNWTAAYATGLLCARRALTKLSLADKYEGVAEPDGTISLTETIEGDDVPRPFKCYLDVGLKRTSTGSRVFGALKGASDGGIYIPHNEKRFPGYDPEAKELDAEVLKKYIFGGHVAEYMESLEEEDDERFKKQFSTYLADGIGSEDIEEIYTNAYAAIREDPTFTPTEKTTDWKAESQKYRSSKLTLEQRRERIQAKIEAFQANDGAEEAEEAEEDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JG24</accession>
    <name>A0A2H3JG24_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WOLCODRAFT_143263</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH40861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JG24"/>
    <dbReference type="STRING" id="742152.A0A2H3JG24"/>
    <dbReference type="OMA" id="LNAYMRT"/>
    <dbReference type="OrthoDB" id="5550281at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00084">
        <property type="entry name" value="HMG-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050342">
        <property type="entry name" value="HMGB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN DSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112:SF22">
        <property type="entry name" value="MITOCHONDRIAL TRANSCRIPTION FACTOR A, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09011">
        <property type="entry name" value="HMG_box_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="4">
        <location>
            <begin position="272"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="HMG box" evidence="4">
        <location>
            <begin position="376"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="2">
        <location>
            <begin position="272"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="2">
        <location>
            <begin position="376"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="53"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="199"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="293"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="484"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="53"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="261"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="358"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PCH40861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="509" mass="56928" checksum="86696ACD19FE35F0" modified="2018-01-31" version="1">MSIRDHSPIFSFDEPMQFDPNDSLIFALDDMPPYEAKPPFSWESLSDYSMSSIPFPTSPDSTSSQLESTPYLPPGDRRYGSETLRGQADMAPMTPEFSDGALYTRWLHDPETPPFPSASAPIPIPHAHGFSPAPPQSPYAAYSDSSSAFPDVAAFSPLTAYAALQPLPRSYTPEEDTIMTEALRDDAPYPKPAWAMQLWDAQPPTPGEHDEATVRRAVGARDDATVRRSPGAGAHNEATVRQRKRTETDEEEHAAEKRAESPAPLKSALKPPKLAPSAWQLYFTDWIAQHQRQSSKKLNVAQAAKEAGQEYAKLSPEQKQPYKIRSQQLKELRERELEVYMRSLTPDDIKRENAFRTAQRRAGKSRKSNLKDPNAPKKPLSAYFMFLQRIRSDPELVKEVFGDETETTKQSVLAAAKWRSMTDEERKPFLAQAEQEKLDYETARKMYEEGSPGYASSINFSILPSSPINAMPVPRGSFLRPKVESFSSVESESDGFATDDSNDPLMARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JGT4</accession>
    <name>A0A2H3JGT4_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_96223</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH37979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JGT4"/>
    <dbReference type="STRING" id="742152.A0A2H3JGT4"/>
    <dbReference type="OMA" id="GVMDMVQ"/>
    <dbReference type="OrthoDB" id="5593278at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018788">
        <property type="entry name" value="Proteasome_assmbl_chp_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053720">
        <property type="entry name" value="Psm_Assembly_Chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31051">
        <property type="entry name" value="PROTEASOME ASSEMBLY CHAPERONE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31051:SF1">
        <property type="entry name" value="PROTEASOME ASSEMBLY CHAPERONE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH37979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="159" mass="17429" checksum="58074BA9C2594C8E" modified="2018-01-31" version="1">MQKASSQLAREIDGTITEVLLQSFADRLLVLVTQMGKVGTLIQATIPPTTPLEPSPPHDPSQPNVTPLPTPPSAIQLTPLLGHAPSERIQTLHSLYASQIATIVWTSESTQALEPERRPIVVGLALRKSGEVEGMGLSEQERSVFYEVMDMVRELLTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JH44</accession>
    <name>A0A2H3JH44_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acyl-CoA N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WOLCODRAFT_24800</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase family. ARD1 subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="PCH41510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="742152.A0A2H3JH44"/>
    <dbReference type="OMA" id="MSMQNAN"/>
    <dbReference type="OrthoDB" id="25586at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031415">
        <property type="term" value="C:NatA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990189">
        <property type="term" value="F:protein N-terminal-serine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990190">
        <property type="term" value="F:protein-N-terminal-glutamate acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000037">
        <property type="entry name" value="N-alpha-acetyltransferase daf-31-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045047">
        <property type="entry name" value="Ard1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23091">
        <property type="entry name" value="N-TERMINAL ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23091:SF4">
        <property type="entry name" value="N-TERMINAL AMINO-ACID N(ALPHA)-ACETYLTRANSFERASE NATA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PCH41510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="158" mass="18259" checksum="ED55E4BA0B1AE97A" modified="2018-01-31" version="1">MNIRPARVEDLMGMQACNLQNLPENYTMRYYLYHALTWPQLSYVAEDNKGRIVGYILAKMEEDMEAGEEPHGHVTSISVLRSYRRLGLAKRLMVQSQEAMATVYRASYVSLHVRKSNRAALSLYRDTLGFTVKDIEKKYYADGEDAYAMRLSLKHLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JH59</accession>
    <name>A0A2H3JH59_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_21378</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467965">
        <property type="protein sequence ID" value="PCH39183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JH59"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH39183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="261" mass="28039" checksum="DDE554310D606754" modified="2018-01-31" version="1">MTKQRGPAGIEAVNACRAWMSVITSTPPAALNPAQQYLRGVWWIPQWFLDDNPQAAHHATLGKSEIAVPQPAYDAPAIEWNAYITRFPQHRLPGVRRGENGAPVFTDVVVYCDMIRLVSPLPECKHVKSHLLWQLTGLFASTTVYQVGLQQAGCQPSQVVNLRPIPLDITSNRVAIIQHCAGTGITDDTVQATYSGWAQEYLRTAQPPQSTSTPGAAPATDNTLVVAPQPNPTIASGIDGDTIMAEPGSTTQNGLGVTPSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JHB7</accession>
    <name>A0A2H3JHB7_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_28344</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
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                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
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                <person name="Gaskell J."/>
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                <person name="Hori C."/>
                <person name="Igarashi K."/>
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                <person name="Nagy L.G."/>
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                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Barry K."/>
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                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
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                <person name="Kallen N."/>
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                <person name="Benoit I."/>
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                <person name="Glotzer D."/>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="7">
        <location>
            <begin position="93"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="23"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PCH36574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="191" mass="21769" checksum="5104925BBB4539EF" modified="2018-01-31" version="1">MLDYRKEMCAHLQSQHASQATQSGSSVPFSSKAASSQSRGFKQMNALIRSLSAGGNSLHNDLSRKSQQELTDAQKRELELEACERDQQIVNNELRRYAEEGPVDEEEEEFNLLTYWQLREKTFPTLYRVALDVLPMQASAVPSTMEMLQVLKYSLKEDRLSSTDDWMPNRKEMLRVDASAEEDCEKASLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JJ53</accession>
    <name>A0A2H3JJ53_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_166616</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467865">
        <property type="protein sequence ID" value="PCH36017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JJ53"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH36017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="168" mass="18508" checksum="E96AFEAD26A9CFF5" modified="2018-01-31" version="1">MYNRRTGRAPPHPSCGKDVRRQQAEWSAAGAARCALIARPRRPVADRSNANGDACTVRVTCQCRTEAECPVMRCVVSIAVPRRNAAGQRACVCHDQNSSCSRCHARPRAEQAQRPIVAGTAAVWVGGARRGCVWHSVVHQREFLPRQQRRRQSREVGHERAPGAVAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JJC8</accession>
    <name>A0A2H3JJC8_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mitochondrial glycine transporter</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Solute carrier family 25 member 38 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WOLCODRAFT_70411</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the miochondrial matrix.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>glycine(in) = glycine(out)</text>
            <dbReference type="Rhea" id="RHEA:70715"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion inner membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH41645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JJC8"/>
    <dbReference type="STRING" id="742152.A0A2H3JJC8"/>
    <dbReference type="OMA" id="WGIYEEL"/>
    <dbReference type="OrthoDB" id="1924968at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015187">
        <property type="term" value="F:glycine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904983">
        <property type="term" value="P:glycine import into mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03064">
        <property type="entry name" value="SLC25A38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030847">
        <property type="entry name" value="Hem25/SLC25A38"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46181">
        <property type="entry name" value="MITOCHONDRIAL GLYCINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46181:SF3">
        <property type="entry name" value="MITOCHONDRIAL GLYCINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 10 12" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="2"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="121"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="213"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PCH41645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="305" mass="32603" checksum="F0514430DBC5388B" modified="2018-01-31" version="1">MSNVSQHLISGAVSGFASSICLQPLDLLKTRMQQGDGALKQSGHGGNILSTAREIMRTHGVTGLWRGTAATLLRNVPGVALYFTGLNYTRGFLATSPYFAQTPSDHARAHSGSVLPKLTKWGNLFAGAATRVAVGALLNPFTVLKARYESNLYAYDGVLSAIRSLVRAGPSELFRGVAAASMRDAPYAGLFVLSYEHIKDEVASLVGPTSSASSTAIHGFSAASAGVVAGLATHPFDVVKTKMQVRTEDRYHSLARTISTIYQRRGLSGFFDGALLRILRKPPNSAIAWATYEGVLMVMRPRNTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JJR5</accession>
    <name>A0A2H3JJR5_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glycoside hydrolase family 13 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WOLCODRAFT_25367</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD-104</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468124">
        <property type="protein sequence ID" value="PCH42422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JJR5"/>
    <dbReference type="STRING" id="742152.A0A2H3JJR5"/>
    <dbReference type="OMA" id="MQYFEWN"/>
    <dbReference type="OrthoDB" id="550577at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11318">
        <property type="entry name" value="AmyAc_bac_fung_AmyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013776">
        <property type="entry name" value="A-amylase_thermo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015237">
        <property type="entry name" value="Alpha-amylase_C_pro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006968">
        <property type="entry name" value="PRK09441.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006969">
        <property type="entry name" value="PRK09441.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43447">
        <property type="entry name" value="ALPHA-AMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09154">
        <property type="entry name" value="Alpha-amy_C_pro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001021">
        <property type="entry name" value="Alph-amls_thrmst"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="7">
        <location>
            <begin position="37"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PCH42422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="525" mass="60070" checksum="AA23B5718DD6CC64" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JJU5</accession>
    <name>A0A2H3JJU5_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WOLCODRAFT_17732</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB468124">
        <property type="protein sequence ID" value="PCH42440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JJU5"/>
    <dbReference type="STRING" id="742152.A0A2H3JJU5"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="118"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="123"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="138"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PCH42440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="204" mass="21958" checksum="04FCE49034F32205" modified="2018-01-31" version="1">MANPDPTHVEDAASLDKGQQYGNLTALAQAAATDKSLSAFQGARVYWKATFWCLFMCMGALLWGYDSQVSGGLLSVPSFRRDFGFYDASDSGDYILAARWQSAFNSISSVGGMFGGDEERSRSVAASPSPISSSTNGEQRDSSGRDEQPRCAAIVIACTPDPDRRTRCLGCGWDGVYGAKHALPRKLRGTADDKYILATMQIVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JK83</accession>
    <name>A0A2H3JK83_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_17834</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468124">
        <property type="protein sequence ID" value="PCH42590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JK83"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH42590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="179" mass="20017" checksum="CDEEA8681BD935DD" modified="2018-01-31" version="1">MRVVSARLSGQFPGDIPNIDDVPLSIEADALPRRYITHPLKHPVLAVGARPQVRIVSQLRRISSCAARACAPDRDADVRIARDVYDAMRVGAWDTHEVSVLVREARLGIYQPELRRKMHLKPSLCYYLHKNAHRPGEELKHCITVRIYEREMPSHDRDGGGGGAVPRIDVPLLVQALPG</sequence>
</entry>
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        <lineage>
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            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
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                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468124">
        <property type="protein sequence ID" value="PCH42351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JKG3"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH42351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="173" mass="20032" checksum="D4F6AB5674389CDC" modified="2018-01-31" version="1" fragment="single">MEAEEVNLGTYYGNMFDDAAAAMEAVDDGWYLDTVYNDRLPKNTATDVHRSDPTTDRWVLNTEGDEYLNLNQRPLVRHVEDAEDPWATRWVLDTRGDEILSGLNARTSKHAPRGWAFDTTGDEYLGQWPIVRPAESDDDRWATRWILRDTEEDEIIPKDIAKLRSMTIRNCIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JKS7</accession>
    <name>A0A2H3JKS7_WOLCO</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Agaricomycetes</taxon>
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            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
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                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
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                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
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                <person name="St John F."/>
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                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468124">
        <property type="protein sequence ID" value="PCH42471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JKS7"/>
    <dbReference type="Proteomes" id="UP000218811">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH42471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="159" mass="17288" checksum="7D20B4A9ADF8BA59" modified="2018-01-31" version="1">MLCRRRPAACAPRDGRTLHAPAAPAADRHSHRFRPHCICYHRAPGQRTPLRTALLHILATSLTTDARDATTAARARGDDARPSTRACIDGVPWRHIRLVSQADGVTIAIRCVASSFSPRARSRCARGTFRTISASVASPQAFSLFSRLCGDSADVYETP</sequence>
</entry>
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    <name>A0A2H3JL48_WOLCO</name>
    <protein>
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            <fullName evidence="1">Uncharacterized protein</fullName>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
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                <person name="Lucas S."/>
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                <person name="Martin R."/>
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                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
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                <person name="Stenlid J."/>
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                <person name="Wiebenga A."/>
                <person name="Young D."/>
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                <person name="Eastwood D.C."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467931">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="742152.A0A2H3JL48"/>
    <dbReference type="OrthoDB" id="660550at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH37374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="88" mass="9751" checksum="D8C37FA1B6716BF5" modified="2018-01-31" version="1">MPHFVPRAALTIYELTQNAQLWPHTICAHSAPAAYVIYPIVSDLGELSGNGIEFIDGMMFLECFYTVYDMGISRVSLATTQSTYANNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JL53</accession>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
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                <person name="Gorecki P."/>
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                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
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                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
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                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
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                <person name="Sabat G."/>
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                <person name="Stenlid J."/>
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                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468124">
        <property type="protein sequence ID" value="PCH42601.1"/>
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    <dbReference type="STRING" id="742152.A0A2H3JL53"/>
    <dbReference type="OMA" id="TPFMRIT"/>
    <dbReference type="OrthoDB" id="424402at2759"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH42601.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
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                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD-104</strain>
        </source>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:cell division site"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:cytosol"/>
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        <property type="term" value="C:ubiquitin ligase complex"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:ubiquitin protein ligase activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:protein ubiquitination"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FHA_dom"/>
    </dbReference>
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        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15067:SF7">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE DMA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15067">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17123">
        <property type="entry name" value="zf-RING_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FHA" evidence="8">
        <location>
            <begin position="71"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="215"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="299"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="359"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="302"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="388"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PCH38888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="439" mass="46590" checksum="967D5BECB45B3463" modified="2018-01-31" version="1">MLRRRRSAGTLATTATAQVPNAAVARAAAPAPGVPTSQQAFRIRLVPHLASRTSLRFDPICRDVREGDPPLRIGRFTDRSGLGLAAANALGSNKLAFKSKVVSRAHAEIWVEGGGRFFIKDTKSSSGTFLNHVRLSAAGTESRPSELRDGDLLQLGVDYQGGNEDIYKCVKIKIEMGREWQSHSNPFNANALKQLKAIAIPHEKKTAPKSALPDCCICLFAVTIHQALFIAPCSHAFHYKCIRPLLEVHHPAFSCPLCRTFANLEEDVEVEFDGEADTDSVADVSAAIASVVAVASGGDNDIGSRERDRDAGAETEVEPDAGGARRGRRASANGVLAGISTFPLIDDNAEMDEEMEDLALPPLPEGSPLMTPRDWDGDQTRGLARDNSVSPVPVAAPSSARGVIAVDGDLSEGDGEGSGEGTSDTSGNVGDGAHGKRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JN85</accession>
    <name>A0A2H3JN85_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BAR-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WOLCODRAFT_26090</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB468146">
        <property type="protein sequence ID" value="PCH43640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JN85"/>
    <dbReference type="STRING" id="742152.A0A2H3JN85"/>
    <dbReference type="OMA" id="QTRQDYI"/>
    <dbReference type="OrthoDB" id="446293at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:medial cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990528">
        <property type="term" value="C:Rvs161p-Rvs167p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097320">
        <property type="term" value="P:plasma membrane tubulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07591">
        <property type="entry name" value="BAR_Rvs161p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000014">
        <property type="entry name" value="Protein hob3, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046982">
        <property type="entry name" value="BIN3/RVS161-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037429">
        <property type="entry name" value="Rvs161/Hob3_BAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174">
        <property type="entry name" value="BRIDGING INTEGRATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174:SF3">
        <property type="entry name" value="BRIDGING INTEGRATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00721">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAR" evidence="4">
        <location>
            <begin position="17"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PCH43640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="264" mass="29811" checksum="05394C7CABCADFF4" modified="2018-01-31" version="1">MSWQGFKKSMNRAGTTLLQKTGQIERTVDRDFAEEEAKYKTFEKECQALQKDSKGYLDAMRAMTAAQGRLADTIDVFYGAADKSSEGAMAAHAYKRAIDDLDTGVGRELDAPYRTTVMEPLGKMNAYFPVVNEHISKRNKKLLDYDAARSKMNKLINKPSDDPTKLPKAQQEHDDAKEVFDMLNEQLIAELPQLLDLRVPFFDPSFEAMIRMQCKFAEEGYEKLSGVQRYFADNVRDDYAAGQLDAQVEGVLQEMKELTICGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JNE3</accession>
    <name>A0A2H3JNE3_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein-S-isoprenylcysteine O-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WOLCODRAFT_110034</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + S-adenosyl-L-methionine = [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:21672"/>
            <dbReference type="Rhea" id="RHEA-COMP:12125"/>
            <dbReference type="Rhea" id="RHEA-COMP:12126"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90510"/>
            <dbReference type="ChEBI" id="CHEBI:90511"/>
            <dbReference type="EC" id="2.1.1.100"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.100" evidence="5"/>
    <dbReference type="EMBL" id="KB467931">
        <property type="protein sequence ID" value="PCH37527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JNE3"/>
    <dbReference type="STRING" id="742152.A0A2H3JNE3"/>
    <dbReference type="OMA" id="RFFTWEL"/>
    <dbReference type="OrthoDB" id="422086at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004671">
        <property type="term" value="F:protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007269">
        <property type="entry name" value="ICMT_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052527">
        <property type="entry name" value="Metal_cation-efflux_comp"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43847">
        <property type="entry name" value="BLL3993 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43847:SF1">
        <property type="entry name" value="BLL3993 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04140">
        <property type="entry name" value="ICMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013870834" description="Protein-S-isoprenylcysteine O-methyltransferase" evidence="6">
        <location>
            <begin position="24"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="159"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PCH37527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="245" mass="27022" checksum="3961ED822D38C2D0" modified="2018-01-31" version="1">MAMLSTHSLALHKIPLLILGAIGGHISVLELQTSTDAKERQKYGKDDFVTIARHYLVMKYKVVLWATAISETLVLLAANLPSSLSQRVLEFLTSNGVDSASRVQVTPAFLVGFSFVVFCGITRLVCFRTLGRHFTYSLTVRENHKLITSGPYSVVRHPAYTASVVGNIGMALVHLGSGSWWATSGALETLTGRVFAIIWLTTLVTVSISLIARTQKEDRVLKQEFGPQWDKWAGQTPYRLVPGVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JNF9</accession>
    <name>A0A2H3JNF9_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RhoGAP-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_26144</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468146">
        <property type="protein sequence ID" value="PCH43716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="185175at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039767">
        <property type="entry name" value="RALBP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12783">
        <property type="entry name" value="RALA BINDING PROTEIN 1 RALBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12783:SF5">
        <property type="entry name" value="RALA-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="2">
        <location>
            <begin position="616"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="411"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="484"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="722"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="841"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="873"/>
            <end position="1411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="183"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="539"/>
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        </location>
    </feature>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1015"/>
            <end position="1043"/>
        </location>
    </feature>
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            <begin position="1045"/>
            <end position="1058"/>
        </location>
    </feature>
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        <location>
            <begin position="1062"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1139"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1155"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1237"/>
            <end position="1249"/>
        </location>
    </feature>
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        <location>
            <begin position="1250"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1285"/>
            <end position="1300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1371"/>
            <end position="1392"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH43716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="1411" mass="147269" checksum="FA97D479DF1E6374" modified="2018-01-31" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JNU6</accession>
    <name>A0A2H3JNU6_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Acid protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WOLCODRAFT_122767</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468146">
        <property type="protein sequence ID" value="PCH43862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JNU6"/>
    <dbReference type="STRING" id="742152.A0A2H3JNU6"/>
    <dbReference type="OMA" id="MIQADNI"/>
    <dbReference type="OrthoDB" id="15189at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000008">
        <property type="entry name" value="Cathepsin D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013937722" evidence="6">
        <location>
            <begin position="19"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="7">
        <location>
            <begin position="107"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="303"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="138"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PCH43862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="417" mass="44485" checksum="C7BF28BD01D470B8" modified="2018-01-31" version="1">MFCKASLIAVALALLSSATPVAQESGSTIALTKRGSLTKDDGTFDHDMAIYSTVRTHNKHRQNMINMERNEGRLPAGASIKPARVFRMPHQKRQKEPLTDEENDLEWAGTVSIGTPGQSFLIDFDTGSSDLWVPSVNCTSSTCSTKHKYNAATSSSDVKKPGTFSILYGDGSTVSGPIYTETVNVAGIKSTGQYFSPVNTLSDSFSNDPIDGILGLAFPAISNLRQNPFFSNAVQERAVKSGVFGMKLASSGSELYLGGTDTSQYTGSIEYHSVTGSGFWQASGAKILLSGKSVITGFQTVIDSGTTIMYGPPSAVQTFYKSIPGSKLYDSTNGYYSFPCKSVPSVSFNWGGKNWVISAANFNLGQTYQGSGQCVGALAGQDLGLGNNVWLLGDSFMKNVYTAFSFDKNSVGFATLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JNX2</accession>
    <name>A0A2H3JNX2_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Autophagy protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WOLCODRAFT_138455</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in cytoplasm to vacuole transport (Cvt) and autophagic vesicle formation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Conjugated with ATG12.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Preautophagosomal structure membrane</location>
            <topology evidence="1 6">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ATG5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468146">
        <property type="protein sequence ID" value="PCH43591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JNX2"/>
    <dbReference type="STRING" id="742152.A0A2H3JNX2"/>
    <dbReference type="OMA" id="SIQKAVW"/>
    <dbReference type="OrthoDB" id="272162at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034274">
        <property type="term" value="C:Atg12-Atg5-Atg16 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044233">
        <property type="term" value="C:mitochondria-associated endoplasmic reticulum membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061908">
        <property type="term" value="C:phagophore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019776">
        <property type="term" value="F:Atg8-family ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.190">
        <property type="entry name" value="Autophagy protein Apg5, helix rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007239">
        <property type="entry name" value="Atg5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048940">
        <property type="entry name" value="ATG5_HBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042526">
        <property type="entry name" value="Atg5_HR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048939">
        <property type="entry name" value="ATG5_UblA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042527">
        <property type="entry name" value="Atg5_UblA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048318">
        <property type="entry name" value="ATG5_UblB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13040">
        <property type="entry name" value="AUTOPHAGY PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13040:SF2">
        <property type="entry name" value="AUTOPHAGY PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20637">
        <property type="entry name" value="ATG5_HBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20638">
        <property type="entry name" value="ATG5_UblA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04106">
        <property type="entry name" value="ATG5_UblB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0072">Autophagy</keyword>
    <keyword evidence="3 6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <keyword evidence="4 6" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Autophagy protein ATG5 UblA" evidence="10">
        <location>
            <begin position="27"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Autophagy protein ATG5 alpha-helical bundle region" evidence="9">
        <location>
            <begin position="154"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Autophagy protein ATG5 UblB" evidence="8">
        <location>
            <begin position="255"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="210"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="233"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF20637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF20638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PCH43591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="345" mass="38286" checksum="56918C38A0C0A0DA" modified="2018-01-31" version="1">MSTYAPRHAPSAFTTPAATTLFRRLTWEGTVPLEIRVSSQELPANSDRGLECYYIQAPRVSYLPLLIPELKRFLMDVVFDETAARAIKEDDWWFELDDGNLVKWHWPIGLIYDNHAITMSTRANSSSAQTVPLRLVLHLASPPTDRLLLSPGAEACKQAFMGQLKEADFIRWGNTKRITGLRKAEQDGLWEGIKEHNFEEYWRVASKITPTTTPTRSHSPPPPPSSASLHTRPPSADPGSSGAPDRDGAYNVRSVPARIYLPDGPVLQDLVPPTLEDGSPHTLFHFLRTHLPLLFPEDRPPLAFAIVQGVVAPPDAEMAWLGACMAGADGWLNVCVGLLREGPRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JP13</accession>
    <name>A0A2H3JP13_WOLCO</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_153292</name>
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    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="PCH43235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JP13"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="32"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH43235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="365" mass="40408" checksum="570478BCF990D924" modified="2018-01-31" version="1">MGEPPPLTTIGHGGTIRLTNWDLRHCTGLTTRNVVKPETDPNTPQQSNKQWQTPAQHHWAPPGLTSQGPKGPKQGPPDSNTTSRQRPPEGQRAKPMPKAHPVAIATATKPEHWARTRTAPQRQQAPPLQNATQSPHRTSNTPVEQQRRPLYQPCPSRRPRRTMRAARQAVRRQGGEKYRLGYHRPPKVTGRHRNVTPAPAAAAPADGQGPASQQRHSRSPSTVKGRTGQKASTPTSLRGGVAHANDNRRRSRYRHRDRPSHAYRGPSVQGGPPLKSAGQNPSKYGDRRTLEDAAQLLHHRARHLRISKDLNNYHRTRRTATRAEGQGPTSHVHRLPSGHRQTVGPPTRKKAGTAGTRDTRADHKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JP81</accession>
    <name>A0A2H3JP81_WOLCO</name>
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            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
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        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
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        <lineage>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468053">
        <property type="protein sequence ID" value="PCH40609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JP81"/>
    <dbReference type="STRING" id="742152.A0A2H3JP81"/>
    <dbReference type="OMA" id="PWISRYS"/>
    <dbReference type="OrthoDB" id="2800620at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH40609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="271" mass="31694" checksum="80E13C029FA52852" modified="2018-01-31" version="1">MGMKAQEKQLELCEVSRRLQGKRMLSDRLKLEEKRQVLQRQIEAFEAKALGILPGIDEEDGGRNMYRGDDWMDEEEDDELDAELVDGEEGEDGNEELWQGQANDALHEIRVAIGHKSFLFRNRVRPSNSQKTKTRAWGEVQVVAKMVARHARVYTQARWAMERLRANGDILEKYKVLKPQDLKAITHIMDNTVQGMRNQPMSWIWAVDVAGDTSQSDWLAELQWVNWLRTKARNDRWKEEHAIVLAEMNWTVRYFEKRARDWQEIADGTAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JPG4</accession>
    <name>A0A2H3JPG4_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_144811</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468157">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JPG4"/>
    <dbReference type="Proteomes" id="UP000218811">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="936"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH44076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="1054" mass="113949" checksum="DD47BB3B3CAE3876" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JPI3</accession>
    <name>A0A2H3JPI3_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_77004</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
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                <person name="Sun S."/>
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                <person name="Barry K."/>
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            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Martinez A.T."/>
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    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1396" mass="151303" checksum="3F13737711071065" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JRL0</accession>
    <name>A0A2H3JRL0_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">orotate phosphoribosyltransferase</fullName>
            <ecNumber evidence="5">2.4.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WOLCODRAFT_139260</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.10" evidence="5"/>
    <dbReference type="EMBL" id="KB468168">
        <property type="protein sequence ID" value="PCH44800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JRL0"/>
    <dbReference type="STRING" id="742152.A0A2H3JRL0"/>
    <dbReference type="OMA" id="ANVFYLY"/>
    <dbReference type="OrthoDB" id="5553476at2759"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00119"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004588">
        <property type="term" value="F:orotate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046132">
        <property type="term" value="P:pyrimidine ribonucleoside biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01208">
        <property type="entry name" value="PyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023031">
        <property type="entry name" value="OPRT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004467">
        <property type="entry name" value="Or_phspho_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00336">
        <property type="entry name" value="pyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46683">
        <property type="entry name" value="OROTATE PHOSPHORIBOSYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46683:SF1">
        <property type="entry name" value="OROTATE PHOSPHORIBOSYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="9">
        <location>
            <begin position="72"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PCH44800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="228" mass="24290" checksum="949F54926AC793BE" modified="2018-01-31" version="1">MSTLDKYQSELIEHGMSVGALKFGSFVLKSGRTSPYFFNAGLLADGPVLDTLCSAYAATIASALKSSPGLPQFDVLFGPAYKGIPFAACTALLLHRDHGIDVGFAYDRKEAKDHGEGGVMVGAPVKGKRVLVLDDVATAGTAIRGAIDVVKKEGGEVVGAVLLLDRQEVGKEGKSMIEEVEAVLGGKGSVPTILKMKHLMAWLEKHGRTEELTSMQDYWNQYGAKTSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JS26</accession>
    <name>A0A2H3JS26_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_78326</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468168">
        <property type="protein sequence ID" value="PCH44751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JS26"/>
    <dbReference type="STRING" id="742152.A0A2H3JS26"/>
    <dbReference type="OMA" id="HQGGRGC"/>
    <dbReference type="OrthoDB" id="2749821at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH44751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="829" mass="94169" checksum="5AF5DBC4D3EED881" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JS59</accession>
    <name>A0A2H3JS59_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mannose-6-phosphate isomerase</fullName>
            <ecNumber evidence="5">5.3.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Phosphohexomutase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Phosphomannose isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">WOLCODRAFT_102565</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-mannose 6-phosphate = D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:12356"/>
            <dbReference type="ChEBI" id="CHEBI:58735"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="5.3.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the mannose-6-phosphate isomerase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.8" evidence="5"/>
    <dbReference type="EMBL" id="KB468135">
        <property type="protein sequence ID" value="PCH42743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JS59"/>
    <dbReference type="STRING" id="742152.A0A2H3JS59"/>
    <dbReference type="OMA" id="GECCYYA"/>
    <dbReference type="OrthoDB" id="6605218at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="UniProtKB-UniPathway"/>
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        <property type="entry name" value="cupin_PMI_type_I_N"/>
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    </dbReference>
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        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="Phosphomannose Isomerase, domain 2"/>
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        <property type="entry name" value="PMI_typeI_cat"/>
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        <property type="entry name" value="PMI_typeI_hel"/>
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        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MANNOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20511">
        <property type="entry name" value="PMI_typeI_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PMI_typeI_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001480">
        <property type="entry name" value="Mannose-6-phosphate_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00714">
        <property type="entry name" value="MAN6PISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Phosphomannose isomerase type I catalytic" evidence="13">
        <location>
            <begin position="13"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphomannose isomerase type I helical insertion" evidence="14">
        <location>
            <begin position="201"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00000757"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00002564"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004666"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010772"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00011956"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00018236"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022833"/>
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            <dbReference type="ARBA" id="ARBA00023235"/>
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            <dbReference type="ARBA" id="ARBA00029741"/>
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            <dbReference type="ARBA" id="ARBA00030762"/>
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            <dbReference type="PIRSR" id="PIRSR001480-2"/>
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            <dbReference type="Pfam" id="PF20511"/>
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            <dbReference type="Pfam" id="PF20512"/>
        </source>
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        <source>
            <dbReference type="EMBL" id="PCH42743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="445" mass="48024" checksum="64014B27E4BB5ECD" modified="2018-01-31" version="1">MTKSTTDAAPGSLCRLKAAVQKYPWGRTGSSSLAARLAPNAIGPDFKVDESESYAEIWMGTHPNGPAHLFSDPSISLHTLLQTSPSALLHTHTPSSAHAHVPFLFKILSIEKALPLQAHPDKALGARLRKEKPDLSPDPNHKPEIAVSIGRQLAGEEPGVAFTGFVGFRPLAEIVQSLEGVPELKHAVGDEDAVQAFVERPSKDALKKVYAALLNNGAAGNASKHVQALAERLKRSERSGVTDEQARLVIKAEGQYPGDVGALATTFFMNLFKLKRGEAVYIGADEAHAYLEGDIIECMAISDNVLNSAFSPPEEVKQQIPTFVDMLTYTARPVTHWALPAQPYQGSAHKRTTQYDPPLEEFVVMGTALREGAESRERLEKVNGPTIGIVTRGKVRFGVTEGGAEELVLEEGGVMYVVPGKTVEVELLSADKEGEGEVWWAACLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JSY6</accession>
    <name>A0A2H3JSY6_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Importin-95</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Karyopherin-95</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WOLCODRAFT_153105</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus envelope</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the importin beta family. Importin beta-1 subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="PCH43053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="742152.A0A2H3JSY6"/>
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    <dbReference type="OrthoDB" id="10263328at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="P:protein import into nucleus"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000027">
        <property type="entry name" value="Importin subunit beta-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058584">
        <property type="entry name" value="IMB1_TNPO1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040122">
        <property type="entry name" value="Importin_beta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
        <property type="entry name" value="IMPORTIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25574">
        <property type="entry name" value="TPR_IMB1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ARM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="11">
        <location>
            <begin position="21"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00079884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00083566"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PCH43053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="864" mass="94697" checksum="4C13B08208DFD768" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JT50</accession>
    <name>A0A2H3JT50_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_143847</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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            <end position="175"/>
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    </feature>
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            <end position="225"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="237"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH42059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="276" mass="31475" checksum="B156EED8E6C7A583" modified="2018-01-31" version="1">MSGENQTEVLSLIARVTTGFWPPRQLHLRYLYFVISALYWYDYFLTFGSEASHHGNPFGRILNNTIFKNICSSLITLQLAMEVAILMCSAAFSALRVHALSASNLRMSICTFIFNAVNPSLCIYVFFRHKPRFEGIPLNIQGCGVTLYYHSIQSMVAGRIMAVLADGIVLLISWIRLQDLKTSRHLIQELRSTSLLGVILKDSSIYFLVLLCTDIVCAVFCFLSLRNVWYVIQLVEVLSNWMTISGQLLFWFLVLSSIYARHHRLVTHLSLNLSHL</sequence>
</entry>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
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                <person name="Lucas S."/>
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                <person name="Martin R."/>
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                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
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                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR42115">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
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        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="1">
        <location>
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        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH44905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
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    </evidence>
    <sequence length="158" mass="17653" checksum="722D5A57FE056D3F" modified="2018-01-31" version="1">MATLSAASEPQLAGFSLSSADKYRGAVVEDLQLQPAFALPLDEPISRAIELAYERDFSQFPVLDHNRKPLGYLDVAALKGKWEAGEANPSDRVSQYMTKFIRSASQPYTIITPSTPLAELEEFLRHNIFALITDQDRKFVLGIVTSQDLENFVSRRGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
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        <recommendedName>
            <fullName evidence="9">Peptidase M48 domain-containing protein</fullName>
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    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
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                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
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                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034982">
        <property type="term" value="P:mitochondrial protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Mito/Outer_Membr_Metalloprot"/>
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        <property type="entry name" value="Peptidase_M48"/>
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    <dbReference type="PANTHER" id="PTHR22726">
        <property type="entry name" value="METALLOENDOPEPTIDASE OMA1"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR22726:SF18">
        <property type="entry name" value="PEPTIDASE M48 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
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        <property type="match status" value="1"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="Pfam" id="PF01435"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH42389.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
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    <name>A0A2H3JU67_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
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    <organism evidence="2 3">
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468053">
        <property type="protein sequence ID" value="PCH40254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JU67"/>
    <dbReference type="OMA" id="WSYEPIY"/>
    <dbReference type="OrthoDB" id="1259151at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH40254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="481" mass="52112" checksum="9BBC3A61604E4680" modified="2018-01-31" version="1">MDFQTLPGDVIIAVMRYLDARSLAALARTCRFIHTLVNESGWGLYVRLNPRTSYSLHKSLLTWDPRAQVRYHVHTDRNWAHAEFVARPLSRKWRGKLQPMLAINSSHLFVGVGNTIYLYTFVAAKAGTAPAIRFESFYTTSGRLQAACDITSITAVADAGLDRTVYVGYADGALERVVLPPADVDGKLIDPLSRDRYEFHTNDIVESLSSGDNYLLSLSSSGIAMFMNLASPSSTPDLLDLQARSWSTYLSTRGSSPYAVFGTSSVSPLVVHDIRPSGLSSDPFAVLTSGTDEGATRQSAVYGIAGAPPSSPWGSSDQILVSGWYDGPVRVHDLRSSSRTSSSCSAGGPASLKPVLSVYDPWLFEPNYSVSCGGGSSSYIAAGTARHSVVALWDVRSPATGWSVHAPGNDSSPVYSVILESSRLFGATQSRPFVLDFGPDSAEETYPDLSVDLHEAGRVEGLKKRDKRGIGFYVTKYSHSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JU94</accession>
    <name>A0A2H3JU94_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">40S ribosomal protein S19</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WOLCODRAFT_136763</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS19 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468053">
        <property type="protein sequence ID" value="PCH40284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JU94"/>
    <dbReference type="STRING" id="742152.A0A2H3JU94"/>
    <dbReference type="OMA" id="WAPFVKT"/>
    <dbReference type="OrthoDB" id="428974at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000118">
        <property type="entry name" value="40S ribosomal protein S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001266">
        <property type="entry name" value="Ribosomal_eS19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11710">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11710:SF0">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01090">
        <property type="entry name" value="Ribosomal_S19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01413">
        <property type="entry name" value="Ribosomal_S19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="138"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PCH40284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="163" mass="18241" checksum="98B5F4CACBEB1992" modified="2018-01-31" version="1">MPGVRDISAEAFISAYASHLKRSGKLEVPTWVDIVKTGAFKELAPYDPDWYYVRAAAVARHIYLRKDVGVGALTKLHGGRHRRGNRPSHHADCSASVQRKICQSLEKIGVLEQTDNGGRRLSQDGRRDLDRIATAVVEAAREEEEEEEEEEAEEAEAEAEEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JVF3</accession>
    <name>A0A2H3JVF3_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Carbamoyl phosphate synthase arginine-specific small chain</fullName>
            <ecNumber evidence="3">6.3.5.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Arginine-specific carbamoyl phosphate synthetase, glutamine chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">WOLCODRAFT_138709</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-glutamine + H2O = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>hydrogencarbonate + L-glutamine + 2 ATP + H2O = carbamoyl phosphate + L-glutamate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterodimer composed of 2 chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CarA family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.5" evidence="3"/>
    <dbReference type="EMBL" id="KB468146">
        <property type="protein sequence ID" value="PCH43963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JVF3"/>
    <dbReference type="STRING" id="742152.A0A2H3JVF3"/>
    <dbReference type="OMA" id="CFSVQYH"/>
    <dbReference type="OrthoDB" id="1924069at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:glutamine metabolic process"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01744">
        <property type="entry name" value="GATase1_CPSase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000016">
        <property type="entry name" value="Carbamoyl-phosphate synthase arginine-specific small chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.20:FF:000003">
        <property type="entry name" value="Carbamoyl-phosphate synthase arginine-specific small chain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.20">
        <property type="entry name" value="Carbamoyl-phosphate synthase small subunit, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01209">
        <property type="entry name" value="CPSase_S_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050472">
        <property type="entry name" value="Anth_synth/Amidotransfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006274">
        <property type="entry name" value="CarbamoylP_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002474">
        <property type="entry name" value="CarbamoylP_synth_ssu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036480">
        <property type="entry name" value="CarbP_synth_ssu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035686">
        <property type="entry name" value="CPSase_GATase1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01368">
        <property type="entry name" value="CPSaseIIsmall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009475">
        <property type="entry name" value="PRK12838.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43418:SF7">
        <property type="entry name" value="CARBAMOYL-PHOSPHATE SYNTHASE SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43418">
        <property type="entry name" value="MULTIFUNCTIONAL TRYPTOPHAN BIOSYNTHESIS PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00988">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00097">
        <property type="entry name" value="ANTSNTHASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00099">
        <property type="entry name" value="CPSGATASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00096">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01097">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52021">
        <property type="entry name" value="Carbamoyl phosphate synthetase, small subunit N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carbamoyl-phosphate synthase small subunit N-terminal" evidence="15">
        <location>
            <begin position="30"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PCH43963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="443" mass="47582" checksum="5E1E83B2FF43AF65" modified="2018-01-31" version="1">MFARTIFRVPRFYRGLATHATHTPAVSASLPAVLHLKTGQSFTGRSFGAPRSIYGETVFSTSITSYTESMTDPSYRGQILVFTTPLVGNYGVPRNTAPVDSQDVGVVLESSTIQCAAVVVADVAERFSHHAAVESLASWCARNGVPGITGVDTRAITTLLRDQGTTLGRLAVGTDASQPQPKAEEYWDPTTENLVAQVSTKTPYVLNPTGDVKIAVLDFGAKANILRSLVRRGAAVTVLPWDFDFNTIRSQYDGLFLSNGPGDPNHCGVAAAHLRHTLAGWDRPVFGICMGHQVIGMAAGLDAYRMTFGNRGHNQPVLALASAGSIRAGRVYVTSQNHQYALRLQDPFPQGWEPFFINCNDSSVEGIKSTAESGRKVWGVQFHPESAGGPLDTIEMFTDFLAECRAVKAQKVGTRTSDVMSARHAPEVPLPVHDAPQAVAATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JW58</accession>
    <name>A0A2H3JW58_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Anti-silencing function protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WOLCODRAFT_164265</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ASF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468135">
        <property type="protein sequence ID" value="PCH43139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JW58"/>
    <dbReference type="STRING" id="742152.A0A2H3JW58"/>
    <dbReference type="OMA" id="DYADQEM"/>
    <dbReference type="OrthoDB" id="29755at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1490">
        <property type="entry name" value="Histone chaperone ASF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006818">
        <property type="entry name" value="ASF1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036747">
        <property type="entry name" value="ASF1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12040">
        <property type="entry name" value="ANTI-SILENCING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12040:SF0">
        <property type="entry name" value="HISTONE CHAPERONE ASF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04729">
        <property type="entry name" value="ASF1_hist_chap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101546">
        <property type="entry name" value="ASF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PCH43139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="194" mass="21440" checksum="74077EDBD5743B1C" modified="2018-01-31" version="1">MSIVTIRNVEFLNNPARFLDPYHFRVTFECIAPLPEDLEWRLIYVSSPGNEELDQELDDCLVGPVPAGVNAFDFEGSPPNPAKIPPEDVLGVAALILTGSYKDQEFVRVGYYQNTEYDNEEMKEALPEPIQFDRLVRDINSKPRVTRFQIKWDIAPPQSGHAVSAGAVNSAAVPSANDLDVDMDDATPSTNGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JYB1</accession>
    <name>A0A2H3JYB1_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WOLCODRAFT_26276</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468146">
        <property type="protein sequence ID" value="PCH43889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JYB1"/>
    <dbReference type="STRING" id="742152.A0A2H3JYB1"/>
    <dbReference type="OMA" id="PYLCCGL"/>
    <dbReference type="OrthoDB" id="5290825at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015798">
        <property type="term" value="P:myo-inositol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015791">
        <property type="term" value="P:polyol transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000100">
        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF25">
        <property type="entry name" value="SUGAR TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G05830)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="214"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="249"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="372"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="409"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="438"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="465"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="504"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="536"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="115"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PCH43889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="624" mass="69904" checksum="89C1B001EC05C2CF" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JZ81</accession>
    <name>A0A2H3JZ81_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_137658</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468124">
        <property type="protein sequence ID" value="PCH42044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JZ81"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH42044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="86" mass="9578" checksum="D4905BEC60A7E2BF" modified="2018-01-31" version="1">MTLAWRSLATGRCAQHNGDMSKRAQCMTYIPNPECACTSVCRADFAILCEQVACSNDIAKIQYLESSLHTCPSYPHQISTCFKDLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K0M1</accession>
    <name>A0A2H3K0M1_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-histidine N-methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.85</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WOLCODRAFT_139183</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the methyltransferase superfamily. METTL18 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.85" evidence="3"/>
    <dbReference type="EMBL" id="KB468168">
        <property type="protein sequence ID" value="PCH44719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K0M1"/>
    <dbReference type="STRING" id="742152.A0A2H3K0M1"/>
    <dbReference type="OMA" id="ADVKFQM"/>
    <dbReference type="OrthoDB" id="1723750at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018064">
        <property type="term" value="F:protein-L-histidine N-tele-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF39">
        <property type="entry name" value="HISTIDINE PROTEIN METHYLTRANSFERASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PCH44719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="431" mass="46677" checksum="D2185F18490002B5" modified="2018-01-31" version="1" fragment="single">MFRFDFEIDEDDLSDPGLGVQEGIATLKDTSQVTQIAQAESAEKQRFEEPYRAYAVDELLATLPPEISFSPLSIPLASTFDDSEQRLSASRPSQVVNIARRDLFDARFQLISLEDHDSDANPSTSGLGVKPETALEFVDAPSDLVPGMYEGGFKTWECALDLVGCLHRIFEKETGRRLKGKKILELGCGTAVPSLYILNRLFSSEPSQDSEEPSDMHIHLQDYNPLVLRLVTMANVLLAWYMSPASQAFRDSVASAPDADSDTFPPADPSTPGTLSITPALKDAFLASLRSHRVHLGLLSGSWATLDLSGAPYDVVFTSETIYRPESLPALIKALRDACLGEAGLEDAAARMSFASAEPKQGDGGGGEENPPHLCLVAAKRVYFGVGGGVSEFVNAVEGLGANANRVGSVQTVWEHTDGVKRIVMQVKWVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K130</accession>
    <name>A0A2H3K130_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">hAT-like transposase RNase-H fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WOLCODRAFT_86211</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB468132">
        <property type="protein sequence ID" value="PCH42724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K130"/>
    <dbReference type="STRING" id="742152.A0A2H3K130"/>
    <dbReference type="OMA" id="KFIHHED"/>
    <dbReference type="OrthoDB" id="3172935at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PCH42724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="189" mass="22060" checksum="DD09E557C1E1D2EA" modified="2018-01-31" version="1">MQHSDFHRCFLHVINLACQAVIKAITNINYSQRDAPEFALNHDPVACVRSLVRVCRASSLRWQYFAEVVTTLKQMNLQLLRDVDTRWSSTLLMIERALMLREAIDKFIHHEDFAELKQYHLSHADWTALEYFKGILEIPHAFQHKLAAEQIPTICNTIPAFEALMRCWRQHKELHPLTTLIVDQGLTKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K186</accession>
    <name>A0A2H3K186_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">40S ribosomal protein S2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WOLCODRAFT_26268</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the universal ribosomal protein uS5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468146">
        <property type="protein sequence ID" value="PCH43878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K186"/>
    <dbReference type="STRING" id="742152.A0A2H3K186"/>
    <dbReference type="OMA" id="PYEEWSD"/>
    <dbReference type="OrthoDB" id="10253125at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000002">
        <property type="entry name" value="40S ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000004">
        <property type="entry name" value="40S ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000851">
        <property type="entry name" value="Ribosomal_uS5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005324">
        <property type="entry name" value="Ribosomal_uS5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005711">
        <property type="entry name" value="Ribosomal_uS5_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013810">
        <property type="entry name" value="Ribosomal_uS5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018192">
        <property type="entry name" value="Ribosomal_uS5_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01020">
        <property type="entry name" value="uS5_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718:SF4">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718">
        <property type="entry name" value="RIBOSOMAL S SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00333">
        <property type="entry name" value="Ribosomal_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03719">
        <property type="entry name" value="Ribosomal_S5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00585">
        <property type="entry name" value="RIBOSOMAL_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50881">
        <property type="entry name" value="S5_DSRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="S5 DRBM" evidence="9">
        <location>
            <begin position="78"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PCH43878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="254" mass="27869" checksum="FFB72898EF930F97" modified="2018-01-31" version="1">MADAGRGRGGFGRGRGDRGRGRRGPRRGGRKDEEKEWVPVTKLGRLVKDGKIKSMEEIYLFSLPVKEYQIVDFFLPKLKDEVMKIMPVQKQTRAGQRTRFKAFVAIGDFDGHVGLGVKCAKEVATAIRGAIILAKLSVIPVRRGYWGAALGEPHTVPSKVSGKVGSVMCRLIPAPRGTGLVAAPASKRLLQLAGVEDCYTQSKGSTATMGNFLKATFAAITKTYAFLTPDLWRQIPLSKYPYDEHSAHLQLRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K1I4</accession>
    <name>A0A2H3K1I4_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RlpA-like protein double-psi beta-barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_138096</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468135">
        <property type="protein sequence ID" value="PCH42884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K1I4"/>
    <dbReference type="STRING" id="742152.A0A2H3K1I4"/>
    <dbReference type="OMA" id="WHFMAKS"/>
    <dbReference type="OrthoDB" id="406505at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22191">
        <property type="entry name" value="DPBB_RlpA_EXP_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051477">
        <property type="entry name" value="Expansin_CellWall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836:SF28">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013749526" description="RlpA-like protein double-psi beta-barrel domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH42884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="136" mass="14909" checksum="7099602E95AD7062" modified="2018-01-31" version="1">MFRLPATFLALCALVSASYALPIRENATLSKRNANDGRATHYEVGLGACGSNDVDSESVLAISRLIYGNGEYCNQWLQITNTANGNVKYGQMRDRCESCGQNDIDLSPSLFEALGADLNQGVLQVEWHFMDKGWSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K2U2</accession>
    <name>A0A2H3K2U2_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_139018</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468157">
        <property type="protein sequence ID" value="PCH44448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K2U2"/>
    <dbReference type="STRING" id="742152.A0A2H3K2U2"/>
    <dbReference type="OMA" id="NAGWHGE"/>
    <dbReference type="OrthoDB" id="17560at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630">
        <property type="entry name" value="DIENELACTONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630:SF44">
        <property type="entry name" value="PROTEIN AIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="27"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH44448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="248" mass="27010" checksum="81413B5BE88DF174" modified="2018-01-31" version="1">MSCADCFSGVIHEGEPEGKIEQFAGVECYIATPSGEYPKDKALLFLTDVFGIPLVNNKLLADGFARNGFKVVMPDIMAGEPLPDSAMGDPNRDRVAWRAKHGPETWDHVVDKVVAALKETGVTRIATTGYCFGAPPAFYLAYKNETHVTIVSHPSMLQIPADLEKYRDVSKAPLLINSCEVDQAFPKEAQATTDELLGGGKFAPGYERTYWDGCTHGFAVRGDLSNPKVKAGKEGAFKASVEFLNKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K462</accession>
    <name>A0A2H3K462_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">The Msin3a Pah1-Sap25 Sid complex</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WOLCODRAFT_51015</name>
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    <organism evidence="5 6">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB468135">
        <property type="protein sequence ID" value="PCH43217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="742152.A0A2H3K462"/>
    <dbReference type="OrthoDB" id="10265969at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070822">
        <property type="term" value="C:Sin3-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1160.11:FF:000001">
        <property type="entry name" value="Paired amphipathic helix protein Sin3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1160.11">
        <property type="entry name" value="Paired amphipathic helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003822">
        <property type="entry name" value="PAH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036600">
        <property type="entry name" value="PAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039774">
        <property type="entry name" value="Sin3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12346:SF0">
        <property type="entry name" value="SIN3A, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12346">
        <property type="entry name" value="SIN3B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02671">
        <property type="entry name" value="PAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47762">
        <property type="entry name" value="PAH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51477">
        <property type="entry name" value="PAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PCH43217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="76" mass="8845" checksum="691B810F43F40763" modified="2018-01-31" version="1" fragment="single">PRSPDSNRPLHITDALSYLDLIKMEFREQPDVYNRFLAIIKAFKEQVIDTPGVIGRICMLFRETPHLIQGFNTFLP</sequence>
</entry>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
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                <person name="Lucas S."/>
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                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
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                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD-104</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="WD40_rpt"/>
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    </dbReference>
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            <end position="28"/>
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        <source>
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        <source>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Martinez A.T."/>
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                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
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                <person name="Benoit I."/>
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                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
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                <person name="Hesse C."/>
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                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
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                <person name="Kohler A."/>
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                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
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                <person name="Lindquist E."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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        </location>
    </feature>
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    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH44784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="620" mass="67116" checksum="4E61359D1DA10D21" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Patyshakuliyeva A."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH44657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="243" mass="26732" checksum="0B0826ABD5985E32" modified="2018-01-31" version="1" fragment="single">VSALWMLSTTNITCNIIINTLAFVDHSDSGRPFFFLADSQQLPINVASIATCTASLILADAFLLYRCEVIWQRLRVTLPLGLLYIMSVVLAVIECFYVTRGGGNIWTGSTSGGPFLPYVAFTGCLHIAFTTFILGRLSFYLRYLPETVMAQNNLNFSGTIPLTVESALPYAVVSFIWMILSCTGSVGANPFVPLLVQLQGITTGLIVIRIANDSAWSLTFLQVAAQKSRTGLDRPTWLRKSFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K897</accession>
    <name>A0A2H3K897_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WOLCODRAFT_133337</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468168">
        <property type="protein sequence ID" value="PCH44687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K897"/>
    <dbReference type="STRING" id="742152.A0A2H3K897"/>
    <dbReference type="OrthoDB" id="300709at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05251">
        <property type="entry name" value="NmrA_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF14">
        <property type="entry name" value="SNOAL-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="39"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PCH44687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="403" mass="44648" checksum="15236812E8135A06" modified="2018-01-31" version="1">MKEARTLFPRGISVRPYKADARTMAIGPTHSDMSSAPREKKLILVLGATGAQGIAVIDKLLAPDADGLPSPYAVRAFTRDPNGERARALAARGVECVQGDWTNFASVAAALSGVYGAWVNTDGTTVNEMTELWCGVRIFELAQQAGVRHCVYSAQDYEFGLGNWDPKYRCHHMDGKGYVADWMKSQPSVVSDTGMTWSIVCTSPYMEMFYEQMFGPVKRRDDGTLVFAAPIGDGRMPIIALADVGYFARYTLDNRTALSGTELRVASDSVSWAEVAETFARLTGQKAEYVPLSEEQWFGLFRKADRPFAGTPSIGEGPITWQENFSAWWAMGRDNLLPRDLEWVRRIHPGAYTLERWMKENKYGEDEDALFQWQRGGSGGFLKDVADGATGMLPLNFDNVAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-05-03" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K9M0</accession>
    <name>A0A2H3K9M0_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_19368</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468168">
        <property type="protein sequence ID" value="PCH45107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K9M0"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013615089" evidence="1">
        <location>
            <begin position="22"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH45107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="329" mass="35607" checksum="667890A7F9FF7656" modified="2018-01-31" version="1">MSCPNEHALATFASSLTCVHLLSLSALPNSCHVHYHLTNLLHATVLVINNIITEHKATVVTATPEATPKATPEPTPEPTAATIAHRIAKITQHISSLLVLLQQLSSIISTVPTGNQAAIKDQVLAMLGTSAEQPVNETHILCHKCTASPPPMNSTVQFHPQFGTAVLLGPMWSSETLVQHRLNAFSCTYHDIAQRWVTDAGTSADTAYEVTTTTILKLVHLLSDHIGANQFPAIVRHVAIQGIPWRGTSAPHISCIVMAATSSVTAYADNVHPRMHATIAVMHTLDSGIRHATHDVNAEAWPGTQLPTPTNVWGTPHHVWFMMHIKVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IUN6</accession>
    <name>A0A2H3IUN6_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Indigoidine synthase A-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WOLCODRAFT_135274</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH33700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3IUN6"/>
    <dbReference type="STRING" id="742152.A0A2H3IUN6"/>
    <dbReference type="OMA" id="FNCIIAT"/>
    <dbReference type="OrthoDB" id="198885at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004730">
        <property type="term" value="F:pseudouridylate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1790.10">
        <property type="entry name" value="Indigoidine synthase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01876">
        <property type="entry name" value="PsiMP_glycosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022830">
        <property type="entry name" value="Indigdn_synthA-like"/>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Barry K."/>
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                <person name="Kallen N."/>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
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                <person name="St John F."/>
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                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
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    <comment type="catalytic activity">
        <reaction evidence="13 26">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
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            <dbReference type="ChEBI" id="CHEBI:61557"/>
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        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
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    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH33991.1"/>
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        <property type="term" value="C:RNA polymerase II, core complex"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:DNA-templated transcription"/>
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        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="RNA polymerase alpha subunit dimerisation domain"/>
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        <property type="entry name" value="RNA polymerase Rpb2, domain 2"/>
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        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
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        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
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        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
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        <property type="entry name" value="RNA_pol_bsu_CS"/>
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        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
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        <property type="entry name" value="RNA_pol_Rpb2_2"/>
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        <property type="entry name" value="RNA_pol_Rpb2_3"/>
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        <property type="entry name" value="RNA_pol_Rpb2_5"/>
    </dbReference>
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        <property type="entry name" value="RNA_pol_Rpb2_7"/>
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        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
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        <property type="entry name" value="PRK09606.1"/>
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    </dbReference>
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        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RNA_pol_Rpb2_5"/>
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    </dbReference>
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        <property type="entry name" value="RNA_pol_Rpb2_6"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
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    </dbReference>
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        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 15" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 15" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RNA polymerase beta subunit protrusion" evidence="20">
        <location>
            <begin position="50"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="19">
        <location>
            <begin position="228"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="21">
        <location>
            <begin position="492"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="22">
        <location>
            <begin position="590"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="23">
        <location>
            <begin position="678"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase subunit 2 hybrid-binding" evidence="17">
        <location>
            <begin position="755"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="18">
        <location>
            <begin position="1129"/>
            <end position="1220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="926"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
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    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU363031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF04566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF04567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="PCH33991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="1228" mass="139521" checksum="0D756AC555724AE3" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IYG5</accession>
    <name>A0A2H3IYG5_WOLCO</name>
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        <submittedName>
            <fullName evidence="2">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_91376</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="F:oxidoreductase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
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        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052228">
        <property type="entry name" value="Sec_Metab_Biosynth_Oxidored"/>
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    <dbReference type="PANTHER" id="PTHR47534:SF3">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47534">
        <property type="entry name" value="YALI0E05731P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH35022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="301" mass="33110" checksum="500387B805734953" modified="2018-01-31" version="1">MPSLAFARAANCTFTPKAPPVAVFLGGTSGIGQAICRALAHYTRGNTHVVICGRNRSSADATLTSLPGSAQPNQREFISCDATLMRSVEDTTSSLLSGLQKVNFLVLSPGFMNLRGRDESPEGIDKRLALNYYARWKFIQDLMPLLRKARDNGEDASVMTVLAPGTGWKIDLDDLGLKKSYSAFKALSAVPTYNDLMIERFAEREPGLSFAHAFPGIVRTPLLGRLPSLLLYPITVSPEDCAEYLLYALLTGGPGAHRVDNKAGDMGKRRYFGSDEARERLWEHTVEEIRRALTQWNDLQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IYP4</accession>
    <name>A0A2H3IYP4_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WOLCODRAFT_133735</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467843">
        <property type="protein sequence ID" value="PCH35112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3IYP4"/>
    <dbReference type="STRING" id="742152.A0A2H3IYP4"/>
    <dbReference type="OMA" id="MVNQIFL"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000002">
        <property type="entry name" value="2,5-diketo-D-gluconic acid reductase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF3">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="7">
        <location>
            <begin position="18"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="6">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PCH35112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="293" mass="32397" checksum="44660353EF9BBAE9" modified="2018-01-31" version="1">MPASKFVKLNTGALMPTLGLGTWKSAPGAVEKAVEVALKNGYRHIDTAQAYENEREVGLGIKNSGVPREEIFLTTKLNNSRHRDPEVALEDSLAALDTPYLDLWLMHWPCPMKSGRPDREVNWLNTWKKMEQIYKAHPENVRAIGVSNISIKYFQELLAVAEVVPAVNQIESHPSLTQEELVQFCISKGISVTAYSPLGSDNAPLARNAVVQQIAKAHGVNPTTILISFHANRPEVTVIPKSVTPERIISNMTIVDLSASELQELKEIEKTSPSRVCKPFWTGYGAIGFPDCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IYV5</accession>
    <name>A0A2H3IYV5_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_139467</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467832">
        <property type="protein sequence ID" value="PCH34615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3IYV5"/>
    <dbReference type="STRING" id="742152.A0A2H3IYV5"/>
    <dbReference type="OMA" id="IANDGHW"/>
    <dbReference type="OrthoDB" id="2756573at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH34615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="218" mass="24014" checksum="B18C5360759F641D" modified="2018-01-31" version="1">MKIANDGHWSYDYVVYVGTIPVCTQDSDISTSVYNRLLFATRICAVLGDAVVLIITWRHTYRIRREANEANMKTSFLTLLLMDGTLYFSCLLSLSALQLATALVLEKEINSTFLTYTSTFISPISSVLISRFMLNLRQVSRGDNGQVNSPTLSSVPALWGVESSSQMASLRFVGNMGAPLDHGASWGSLAGTDADADVLESEEYLMHENDDGTSDEKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IZ08</accession>
    <name>A0A2H3IZ08_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Spindle pole body interacting protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_79883</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467843">
        <property type="protein sequence ID" value="PCH35230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3IZ08"/>
    <dbReference type="STRING" id="742152.A0A2H3IZ08"/>
    <dbReference type="OMA" id="GRHFWAQ"/>
    <dbReference type="OrthoDB" id="66409at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052809">
        <property type="entry name" value="Actin_polarity_regulatory"/>
    </dbReference>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
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                <person name="Kuo A."/>
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            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Riley R."/>
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                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">MD-104</strain>
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    </reference>
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        <text evidence="2">Glycan metabolism; N-glycan metabolism.</text>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 31 family.</text>
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        <property type="term" value="C:glucosidase II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:alpha-glucosidase activity"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:carbohydrate binding"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:carbohydrate metabolic process"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:N-glycan processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="GH31_GANC_GANAB_alpha"/>
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    </dbReference>
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        <property type="entry name" value="GH31_N"/>
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        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
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    </dbReference>
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        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="DUF5110"/>
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        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF54">
        <property type="entry name" value="BCDNA.GH04962"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17137">
        <property type="entry name" value="DUF5110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 10 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013931013" description="Glucosidase II subunit alpha" evidence="11">
        <location>
            <begin position="19"/>
            <end position="966"/>
        </location>
    </feature>
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        <location>
            <begin position="85"/>
            <end position="321"/>
        </location>
    </feature>
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        <location>
            <begin position="365"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="15">
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            <begin position="708"/>
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        </location>
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    <feature type="domain" description="DUF5110" evidence="14">
        <location>
            <begin position="818"/>
            <end position="870"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00042895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PCH35732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="966" mass="107689" checksum="3A19782E4FE7E201" modified="2018-01-31" version="1"> </sequence>
</entry>
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    <accession>A0A2H3J0T9</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_140115</name>
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    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
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            <taxon>Agaricomycetes</taxon>
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            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH35870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="165" mass="17194" checksum="CB05E04AEEC00BDC" modified="2018-01-31" version="1">MQSRQIMPTPASPPQSASAPLKKQRRKSASHGGRMSSVVARSHHVSSEDVEHLASAFDSLVDAGTSIASTVIQAKQNKRDDDVALILRSLYNDASTATDDNTQYGSEAFSLGSIFSGIGKLVGTVAKHSKDIENVGSAVESVADAGSTIASVVEQAHQSSQTAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J1G5</accession>
    <name>A0A2H3J1G5_WOLCO</name>
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        <submittedName>
            <fullName evidence="4">DUF926-domain-containing protein</fullName>
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        <name evidence="4" type="ORF">WOLCODRAFT_140225</name>
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    <organism evidence="4 5">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NKAP family.</text>
    </comment>
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        <property type="protein sequence ID" value="PCH36100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="742152.A0A2H3J1G5"/>
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    <dbReference type="OrthoDB" id="273141at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <source>
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    </evidence>
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            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
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                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
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                <person name="Morin E."/>
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                <person name="Nagy L.G."/>
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                <person name="Ohm R.A."/>
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                <person name="Stenlid J."/>
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                <person name="Sun S."/>
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        </source>
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                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
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                <person name="Benoit I."/>
                <person name="Boyd A."/>
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                <person name="Copeland A."/>
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                <person name="Heitman J."/>
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                <person name="Kallen N."/>
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    </dbReference>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
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    </evidence>
    <sequence length="243" mass="26268" checksum="D3D6B4CCA5193EAD" modified="2018-01-31" version="1">MDNTDLETYQVQLSQVELALSTDPDNAGLSSLRSELQELIELTEAAIAQQEAAATSSKAESSRKAATAAATTRAWAAGDECLAKYSGDNAWYPARITSVGGSTENRAYSVMFKSYNTTELLNASQLKPLSPNYQSAGPSALGKRKLSKAEEEERERKKKKNEKKVEARAAKAKEQTEKQASWQKFAKKSEKKGIHIAGVSGTSIFKTPDNPLGKVGVTGSGKGMTEVAPRHKHKFEAKDEANA</sequence>
</entry>
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            <fullName evidence="4">F-box domain-containing protein</fullName>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
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                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467876">
        <property type="protein sequence ID" value="PCH36306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J295"/>
    <dbReference type="STRING" id="742152.A0A2H3J295"/>
    <dbReference type="OMA" id="LCEMICA"/>
    <dbReference type="OrthoDB" id="2921803at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="467"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH36306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="492" mass="55940" checksum="0C8E723D86FD2894" modified="2018-01-31" version="1">MARADGWHSFERDGLWYEGTDLDEDVWPDYPWEEKLPKRVLRPLPPRISARIPAETTDLIIDFLHKDRPSLLACARVSRQWYSRSQYHLYTIFTMGRVTFYELAAIVKTIPPAKSPLRAVRTLTIVESSGRTFLRAVPVSLGPHMCHIANLHLLGDETPVKPQDKPSAIRLHLDAPFLILFPLLASNVTHFNLDTWTLSSFADLQRLLLSLPRLQELILSKLSTRGSSRAIVKPPGASPQKLQLLQRLVMKRLARNVLDVFASWLISVLPPLVLRHVEYTVVDPNAWPSDAMKRLLAGFGNSIDQLHIALHDDSEPPNMDGCLHLRWLQLHQHIYLDSDATKFRDHLAHVLRDIPSRRMRSLSIIFYVASSERSRNPIDTLVRYAAKLDELDNALQQHDNEHPAGHPKPFKLTSYPVFKSLEVVDVILGDVTVSDTDHIAPAYRALTQLKSVFSRWCGGIVRAGCREGDGSEDWRSIECPEDDVRSDERAHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J2W0</accession>
    <name>A0A2H3J2W0_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">sphinganine-1-phosphate aldolase</fullName>
            <ecNumber evidence="14">4.1.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Sphingosine-1-phosphate aldolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">WOLCODRAFT_140194</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">MD-104</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 16 17">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the group II decarboxylase family. Sphingosine-1-phosphate lyase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.27" evidence="14"/>
    <dbReference type="EMBL" id="KB467865">
        <property type="protein sequence ID" value="PCH36045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J2W0"/>
    <dbReference type="STRING" id="742152.A0A2H3J2W0"/>
    <dbReference type="OMA" id="FKDHQFT"/>
    <dbReference type="OrthoDB" id="10254570at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008117">
        <property type="term" value="F:sphinganine-1-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030149">
        <property type="term" value="P:sphingolipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000020">
        <property type="entry name" value="sphingosine-1-phosphate lyase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050477">
        <property type="entry name" value="GrpII_AminoAcid_Decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42735">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42735:SF6">
        <property type="entry name" value="SPHINGOSINE-1-PHOSPHATE LYASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 17" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 16 17" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="18" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="16">
        <location>
            <position position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00042568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PCH36045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="569" mass="60871" checksum="A65F6D41C60D4EBD" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J2W1</accession>
    <name>A0A2H3J2W1_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_134886</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH33079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J2W1"/>
    <dbReference type="STRING" id="742152.A0A2H3J2W1"/>
    <dbReference type="OrthoDB" id="347657at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH33079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="145" mass="15454" checksum="3599B2FD84759ADE" modified="2018-01-31" version="1">MSTLTPRTCHAIFTGGRFPGMTPRLGRKKASGSGDRFEQTSSGVSVMDSVDESEDHMDAVMREMYGSRWNLGTSASELAHAGGADPRAYMGMTRTGVGLGLGEDALETSRADRRAPVPPAEHSTLTPESTLRLVPPSLHGPDSYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J325</accession>
    <name>A0A2H3J325_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_147239</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH33139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J325"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH33139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="152" mass="16536" checksum="0FF72F34F097FDF6" modified="2018-01-31" version="1">MQAQDTSGDVVVLGISTMLQTEGHPSYRHAGERTAQRMTTATERADEAQTDKVPRRQRNIFVYKWKTTHPDGRKDEFDKAFSALSKEQLQVYTAATNELDATSGALPYRRRAPGSDDSSITVHDGHGIAPTPCVTTSATAASEHPAHALGPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J3E2</accession>
    <name>A0A2H3J3E2_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Methylenetetrahydrofolate reduct</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WOLCODRAFT_140258</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD-104</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the methylenetetrahydrofolate reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467876">
        <property type="protein sequence ID" value="PCH36215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J3E2"/>
    <dbReference type="STRING" id="742152.A0A2H3J3E2"/>
    <dbReference type="OMA" id="AWKEEFY"/>
    <dbReference type="OrthoDB" id="16284at2759"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004489">
        <property type="term" value="F:methylenetetrahydrofolate reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00537">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.220:FF:000002">
        <property type="entry name" value="Methylenetetrahydrofolate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004621">
        <property type="entry name" value="Fadh2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003171">
        <property type="entry name" value="Mehydrof_redctse-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053806">
        <property type="entry name" value="MTHFR_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00677">
        <property type="entry name" value="fadh2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45754">
        <property type="entry name" value="METHYLENETETRAHYDROFOLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45754:SF3">
        <property type="entry name" value="METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02219">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21895">
        <property type="entry name" value="MTHFR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="FAD-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MTHFR SAM-binding regulatory" evidence="9">
        <location>
            <begin position="304"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PCH36215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="604" mass="68765" checksum="CA7CA2D90DBE921C" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J3G9</accession>
    <name>A0A2H3J3G9_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WOLCODRAFT_166975</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KB467876">
        <property type="protein sequence ID" value="PCH36511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J3G9"/>
    <dbReference type="STRING" id="742152.A0A2H3J3G9"/>
    <dbReference type="OrthoDB" id="1668230at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
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</entry>
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    <accession>A0A2H3J4D4</accession>
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        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
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    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
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                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
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                <person name="Martin R."/>
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                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
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                <person name="Ohm R.A."/>
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                <person name="Sun S."/>
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                <person name="Young D."/>
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                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
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            <dbReference type="DOI" id="10.1126/science.1221748"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
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        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
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                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
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                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
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                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
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                <person name="Samejima M."/>
                <person name="Schmutz J."/>
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                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
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            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="196"/>
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    </feature>
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        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH34643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="268" mass="29710" checksum="F11AF68CE4520369" modified="2018-01-31" version="1">MTRTASGANPSARRRRLPTPEEFERARKASATSSHHQAQCQSTFGDNRLRRSSRPVVNEPGANCVQEQQSIRHDDIVTDKLAKAAIPETTMMHSKITRSQNAVPQFTEPPSDDPEPVASRKRGRQDNGNEQDRGHHKRSRVCVAPAEERLQPDQMQSAGPLAILPDPNVSRKRGRQDGDGSSTSQSFQAGNRPHKRRNLAHGAAPQRVSPGILATQHAFCEKTLDPSSPRSGLAHYIRGSRCQRCGTRHRYDGGYDDEIRDIEYNVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J4N3</accession>
    <name>A0A2H3J4N3_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytoplasmic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_140764</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467909">
        <property type="protein sequence ID" value="PCH37212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J4N3"/>
    <dbReference type="STRING" id="742152.A0A2H3J4N3"/>
    <dbReference type="OMA" id="QVGMTNT"/>
    <dbReference type="OrthoDB" id="3643at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017168">
        <property type="term" value="F:5-oxoprolinase (ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003692">
        <property type="entry name" value="Hydantoinase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045079">
        <property type="entry name" value="Oxoprolinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365:SF2">
        <property type="entry name" value="5-OXOPROLINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365">
        <property type="entry name" value="5-OXOPROLINASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02538">
        <property type="entry name" value="Hydantoinase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydantoinase B/oxoprolinase" evidence="2">
        <location>
            <begin position="14"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="484"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="553"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH37212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="595" mass="63805" checksum="772254AF61596663" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J4Y9</accession>
    <name>A0A2H3J4Y9_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_94220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH33809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J4Y9"/>
    <dbReference type="STRING" id="742152.A0A2H3J4Y9"/>
    <dbReference type="OMA" id="CYERWER"/>
    <dbReference type="OrthoDB" id="5345779at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="432"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH33809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="496" mass="56387" checksum="0E8EB60CB5CC6E59" modified="2018-01-31" version="1">MAQLLPPEIWLQIFSYAADDDSLFDHALPTSLWDSAWTRMLYGNLWYLRSPDEVLNTKQRQSYFTKKAISATCRAWRTLGAEFLFRFLYFNDPSYLQQFGPILNNNPNYGRWVKRIHITRYYAGLGATMYEMQKSLGSIIRHCPNLEIFVVSWPLSHSFSAVAYALRHRSKTLHTLSLNVPTASLGKAIVMLQTLPSLKSLHLEFEGSCPEDIELGASSDLEIALNDLQQLSLRGPCGDFVEQAIGWKMPSLQSLSLDFLSYRNDLPDIVDFLAHHGAHLTFLDINCIPDLDVPTILDLCPLLTTFAFNLDWRIESAHTDIWGAGTLVHRPHANITTIGCHQLLHAFGVGDAAKYAAADPFTTHVVRRRNDANFAAITRAAFPRLARVRVLNRTLLRDLERADGPARDCYERWERWWDQCAAQGVRLEDCTGAPLGTLPMDDPEDEEVESEVDEDAEEQKKLQPLRDLLEECKRMSLTREEPLFALPPPYRQPLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J5V7</accession>
    <name>A0A2H3J5V7_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="17">ATP dependent helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">WOLCODRAFT_19800</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">RNA-dependent helicase required for nonsense-mediated decay (NMD) of aberrant mRNAs containing premature stop codons and modulates the expression level of normal mRNAs. Also capable of unwinding double-stranded DNA and translocating on single-stranded DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KB467843">
        <property type="protein sequence ID" value="PCH35143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J5V7"/>
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    <dbReference type="OMA" id="LEFNTHG"/>
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        <property type="entry name" value="Helicase_ATP-bd"/>
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        <property type="entry name" value="UPF1_CH/ZBD"/>
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        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="REGULATOR OF NONSENSE TRANSCRIPTS 1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="AAA_11"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="UPF1_CH_RICH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 17" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 15" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Upf1" evidence="16">
        <location>
            <begin position="136"/>
            <end position="294"/>
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    </feature>
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            <begin position="144"/>
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            <begin position="158"/>
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            <dbReference type="ARBA" id="ARBA00022840"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00049390"/>
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            <dbReference type="ARBA" id="ARBA00055561"/>
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    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PCH35143.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="1008" mass="112272" checksum="37680A2C178E0736" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J6H0</accession>
    <name>A0A2H3J6H0_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA helicase</fullName>
            <ecNumber evidence="4">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WOLCODRAFT_92409</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
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        <property type="protein sequence ID" value="PCH37521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolase"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="2.40.30.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
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    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050534">
        <property type="entry name" value="Coronavir_polyprotein_1ab"/>
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    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048761">
        <property type="entry name" value="SMUBP-2_HCS1_1B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788:SF8">
        <property type="entry name" value="DNA-BINDING PROTEIN SMUBP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF21138">
        <property type="entry name" value="SMUBP-2_HCS1_1B"/>
        <property type="match status" value="1"/>
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    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="12">
        <location>
            <begin position="239"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="454"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="522"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="561"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007913"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PCH37521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="812" mass="88946" checksum="626A3DA47D2FD32E" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J6Q7</accession>
    <name>A0A2H3J6Q7_WOLCO</name>
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        <recommendedName>
            <fullName evidence="4">Splicing arginine serine-rich 12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_135705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH34419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J6Q7"/>
    <dbReference type="STRING" id="742152.A0A2H3J6Q7"/>
    <dbReference type="OMA" id="MFAMYLD"/>
    <dbReference type="OrthoDB" id="2139939at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044688">
        <property type="entry name" value="SCI-1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34117">
        <property type="entry name" value="STYLE CELL-CYCLE INHIBITOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34117:SF1">
        <property type="entry name" value="STYLE CELL-CYCLE INHIBITOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH34419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="294" mass="33799" checksum="00071A64B7B2CE0F" modified="2018-01-31" version="1">MPSRRHRSYSRSPSRERRRSRSRSPERSIPLPSGASPISESDYFLKSDEFRVWLKDEKGKYFDELSSDKARKYFRKFVKAWNRGKLRKSLYEGVDAPSASSHTAYRWSFASKASSTDSAVLQAARDEVGAATHNRPSASTSSSRGRTQGPTLPSQSDLTLAREAVEEYRAAERDHKRKRERREEKERVEDLVGPKPVGREGMLEKKRAQRESDRAFRERGDEGLEVDDSTLLGGGDSFKEQIARRDAARRRYEEKRFGARDERMSAAQERADAIRQKDKATMDMFMQMAKDKFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J6Q8</accession>
    <name>A0A2H3J6Q8_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Alpha-galactosidase</fullName>
            <ecNumber evidence="3 7">3.2.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Melibiase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WOLCODRAFT_135945</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 27 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.22" evidence="3 7"/>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH37940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J6Q8"/>
    <dbReference type="STRING" id="742152.A0A2H3J6Q8"/>
    <dbReference type="OMA" id="NAYYCDI"/>
    <dbReference type="OrthoDB" id="5795902at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14792">
        <property type="entry name" value="GH27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002241">
        <property type="entry name" value="Glyco_hydro_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041233">
        <property type="entry name" value="Melibiase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452:SF61">
        <property type="entry name" value="ALPHA-GALACTOSIDASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452">
        <property type="entry name" value="ALPHA-GALACTOSIDASE/ALPHA-N-ACETYLGALACTOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16499">
        <property type="entry name" value="Melibiase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17801">
        <property type="entry name" value="Melibiase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00740">
        <property type="entry name" value="GLHYDRLASE27"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha galactosidase C-terminal" evidence="10">
        <location>
            <begin position="400"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="17"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PCH37940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="516" mass="58049" checksum="CC1FD0B2A261D093" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J6Z0</accession>
    <name>A0A2H3J6Z0_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Oxidoreductase C terminal-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WOLCODRAFT_23028</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
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            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Barry K."/>
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                <person name="Murat C."/>
                <person name="Nagy L.G."/>
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                <person name="Patyshakuliyeva A."/>
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                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
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            <strain evidence="2 3">MD-104</strain>
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        </location>
    </feature>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH38770.1"/>
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    </evidence>
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            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="249" mass="27164" checksum="35462577A4D15D2B" modified="2018-01-31" version="1">MDNSADAANSLGLDLDALEIKDDPEPSGSSEPPAVEASAAPAEQSDAARPAEITQNTSAEEEAKSPTSEGNAKEKKKPYVNPERVKTGGAQRDKLSEQELTERMARIREQNERIKQRRADVQADEDAFKKTQEADRIKAAKTKKVQENIDRTREQNARRKMEKIQGREWDSGKPTQDWKPARRPEEGDDADRAPRASIGIRGAFRGGAVRGRGGRGRGRGRGRMAAQAPPTERLTEESPAVTTPAAAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J977</accession>
    <name>A0A2H3J977_WOLCO</name>
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        <recommendedName>
            <fullName evidence="9 10">M-phase inducer phosphatase</fullName>
            <ecNumber evidence="2 10">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
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        <name evidence="13" type="ORF">WOLCODRAFT_142591</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the MPI phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2 10"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate-cyanide sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000086">
        <property type="term" value="P:G2/M transition of mitotic cell cycle"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010971">
        <property type="term" value="P:positive regulation of G2/M transition of mitotic cell cycle"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110032">
        <property type="term" value="P:positive regulation of G2/MI transition of meiotic cell cycle"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01530">
        <property type="entry name" value="Cdc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.250.10:FF:000021">
        <property type="entry name" value="M-phase inducer phosphatase cdc-25.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000751">
        <property type="entry name" value="MPI_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001307">
        <property type="entry name" value="Thiosulphate_STrfase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828">
        <property type="entry name" value="M-PHASE INDUCER PHOSPHATASE DUAL SPECIFICITY PHOSPHATASE CDC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828:SF17">
        <property type="entry name" value="PROTEIN-TYROSINE-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00716">
        <property type="entry name" value="MPIPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00380">
        <property type="entry name" value="RHODANESE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6 10" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="12">
        <location>
            <begin position="537"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="161"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="347"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="414"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="453"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="736"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="124"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="184"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="213"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="249"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="454"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00067190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PCH38481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="789" mass="86428" checksum="A75A2A0EB266F7BB" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J9C2</accession>
    <name>A0A2H3J9C2_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">triacylglycerol lipase</fullName>
            <ecNumber evidence="6">3.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Autophagy-related protein 15</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">WOLCODRAFT_115618</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Lipase which is essential for lysis of subvacuolar cytoplasm to vacuole targeted bodies and intravacuolar autophagic bodies. Involved in the lysis of intravacuolar multivesicular body (MVB) vesicles. The intravacuolar membrane disintegration by ATG15 is critical to life span extension.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12044"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17855"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.3"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Binds to both phosphatidylinositol (PI) and phosphatidylinositol 3,5-bisphosphate (PIP2).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endosome</location>
            <location evidence="3">Multivesicular body membrane</location>
            <topology evidence="3">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Prevacuolar compartment membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.3" evidence="6"/>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH38521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J9C2"/>
    <dbReference type="STRING" id="742152.A0A2H3J9C2"/>
    <dbReference type="OMA" id="YKCDQGC"/>
    <dbReference type="OrthoDB" id="58570at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032585">
        <property type="term" value="C:multivesicular body membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005775">
        <property type="term" value="C:vacuolar lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034496">
        <property type="term" value="P:multivesicular body membrane disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046461">
        <property type="term" value="P:neutral lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006660">
        <property type="term" value="P:phosphatidylserine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050805">
        <property type="entry name" value="ATG15_Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47175">
        <property type="entry name" value="LIPASE ATG15-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47175:SF2">
        <property type="entry name" value="LIPASE ATG15-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0072">Autophagy</keyword>
    <keyword evidence="8" id="KW-0967">Endosome</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 20" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fungal lipase-type" evidence="19">
        <location>
            <begin position="232"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00024663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00029828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="PCH38521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="416" mass="45959" checksum="F79DDE56818038BD" modified="2018-01-31" version="1">MRLFDLVPSALKYTLLSLLWPKEPPVRTTSLNFELRHEHGLSSSSRIVFADVQPASRFAPIDFTVGTRRLRTHRPASQNDFFNARTNPSLDVAWEELEIDGPDTEDRETLLTLAKMTSNAYQQPIDKEWYDLGTDWNNSYPFGWEPDEDGFRGHIYATPDNSTVVITVKGTSAGWMVGGGGPTTRKDKLNDNLLFSCCCARVGPTWTPVCDCYEGGYKCDQGCLEKSLVEESLFYSVGTNLYYNVTYMYPNSNIWLVGHSLGGSLASLIAVTFGVPAVGIEAPGDRLPAQRLHLPSPPSTQHVTHVFHTGDPIPMGTCTGVSSSCAIGGFALESRCHLGKIIRYDTVSKLGWSADIRGHGIKVIIDKLLSADWESTEEGGRGVPEPVYEDEDCVDCFNWEFGDFRNVSLTTCGMSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JA49</accession>
    <name>A0A2H3JA49_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">WOLCODRAFT_85015</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="KB467954">
        <property type="protein sequence ID" value="PCH39076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JA49"/>
    <dbReference type="STRING" id="742152.A0A2H3JA49"/>
    <dbReference type="OMA" id="CLAAQMD"/>
    <dbReference type="OrthoDB" id="10266508at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071474">
        <property type="term" value="P:cellular hyperosmotic response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06225">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="CDD" id="cd16922">
        <property type="entry name" value="HATPase_EvgS-ArcB-TorS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1530:FF:000003">
        <property type="entry name" value="Atypical/HisK protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000235">
        <property type="entry name" value="Probable nik-1 protein (Os-1p protein)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000010">
        <property type="entry name" value="Sensor histidine kinase RcsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.130:FF:000002">
        <property type="entry name" value="Two-component osmosensing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1530:FF:000002">
        <property type="entry name" value="Two-component osmosensing histidine kinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1530">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339:SF1">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18947">
        <property type="entry name" value="HAMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58104">
        <property type="entry name" value="Methyl-accepting chemotaxis protein (MCP) signaling domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 10" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="HAMP" evidence="14">
        <location>
            <begin position="90"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="14">
        <location>
            <begin position="183"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="14">
        <location>
            <begin position="275"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="14">
        <location>
            <begin position="367"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="14">
        <location>
            <begin position="459"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="14">
        <location>
            <begin position="551"/>
            <end position="604"/>
        </location>
    </feature>
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        <location>
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            <end position="944"/>
        </location>
    </feature>
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        <location>
            <begin position="1089"/>
            <end position="1213"/>
        </location>
    </feature>
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        </location>
    </feature>
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        <location>
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        </location>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JB03</accession>
    <name>A0A2H3JB03_WOLCO</name>
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        <recommendedName>
            <fullName evidence="3 8">Mediator of RNA polymerase II transcription subunit 21</fullName>
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        <name evidence="10" type="ORF">WOLCODRAFT_134943</name>
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        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
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        <lineage>
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            <taxon>Agaricomycetes</taxon>
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            <taxon>Phaeolaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10 11">MD-104</strain>
        </source>
    </reference>
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        <text evidence="8">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
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        <text evidence="8">Component of the Mediator complex.</text>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </evidence>
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        </source>
    </evidence>
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</entry>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
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                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
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                <person name="St John F."/>
                <person name="Stenlid J."/>
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                <person name="Wiebenga A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467920">
        <property type="protein sequence ID" value="PCH37273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
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        <location>
            <begin position="25"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH37273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="105" mass="11859" checksum="978BA99B5E84948F" modified="2018-01-31" version="1">MPRRCLTARRHGNDDDSGVITAAWRPPLGKEPAPVATPAALSRSPPILRNKAKNRAPTTSRIAATSSLITWTSRRSARHHHHPFHHLFPNDRKDGWDRRCHLARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JBZ2</accession>
    <name>A0A2H3JBZ2_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Inositol oxygenase</fullName>
            <ecNumber evidence="4 14">1.13.99.1</ecNumber>
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        <alternativeName>
            <fullName evidence="10 14">Myo-inositol oxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">WOLCODRAFT_139788</name>
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        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
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        <lineage>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Phaeolaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
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                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
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                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
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                <person name="Glotzer D."/>
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                <person name="Kuo A."/>
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                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
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                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
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                <person name="Young D."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">MD-104</strain>
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        <reaction evidence="11 14">
            <text>myo-inositol + O2 = D-glucuronate + H2O + H(+)</text>
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            <dbReference type="ChEBI" id="CHEBI:15378"/>
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            <dbReference type="ChEBI" id="CHEBI:17268"/>
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            <name>Fe cation</name>
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        </cofactor>
        <text evidence="13 14">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Polyol metabolism; myo-inositol degradation into D-glucuronate; D-glucuronate from myo-inositol: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
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    </comment>
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            <position position="47"/>
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        <ligand>
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        <ligand>
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    <feature type="binding site" evidence="13">
        <location>
            <position position="114"/>
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        <ligand>
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        <location>
            <position position="138"/>
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        <ligand>
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        <ligand>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Barry K."/>
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                <person name="Martinez A.T."/>
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                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
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                <person name="Ferreira P."/>
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                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
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                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
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                <person name="Barry K."/>
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                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
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        <location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="2">
        <location>
            <begin position="122"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH40042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="251" mass="27591" checksum="2271BF79DC6AB3B5" modified="2018-01-31" version="1">MGLELSMIGADWAHRSWAFYSTGAYKELSVFKLDTLIQKCFVYALCIFEWVQTALVTVDAFKIIYGLGSEVEVVPVHYPFAWFSSITLLAVVGTSAGIIGSISLMNPQSIKSQIVYAKAIELRKMRTGYRQTNQLVHRLIAMAIETGCLTVSVALLALAFIIAEYKTDLAAIPMLIMPKLYANSVLMSFNNRTFMSREAEEHILTQTLCAVCSGGHQLTNVAEICKSQEEGGTTEEPVIGVDAFSIHSTSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JCR4</accession>
    <name>A0A2H3JCR4_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Phosphotyrosine protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WOLCODRAFT_94095</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the low molecular weight phosphotyrosine protein phosphatase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH33747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JCR4"/>
    <dbReference type="STRING" id="742152.A0A2H3JCR4"/>
    <dbReference type="OMA" id="VCHGNIC"/>
    <dbReference type="OrthoDB" id="3388at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004726">
        <property type="term" value="F:non-membrane spanning protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16343">
        <property type="entry name" value="LMWPTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000105">
        <property type="entry name" value="Low molecular weight phosphotyrosine protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050438">
        <property type="entry name" value="LMW_PTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023485">
        <property type="entry name" value="Ptyr_pPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036196">
        <property type="entry name" value="Ptyr_pPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002115">
        <property type="entry name" value="Tyr_Pase_low_mol_wt_mml"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017867">
        <property type="entry name" value="Tyr_phospatase_low_mol_wt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11717:SF7">
        <property type="entry name" value="LOW MOLECULAR WEIGHT PHOSPHOTYROSINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11717">
        <property type="entry name" value="LOW MOLECULAR WEIGHT PROTEIN TYROSINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01451">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00719">
        <property type="entry name" value="LMWPTPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00720">
        <property type="entry name" value="MAMMALPTPASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00226">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52788">
        <property type="entry name" value="Phosphotyrosine protein phosphatases I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphotyrosine protein phosphatase I" evidence="8">
        <location>
            <begin position="3"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="9"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="15"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR617867-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PCH33747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="150" mass="16727" checksum="D37ED2813DB3E512" modified="2018-01-31" version="1">MAPSVLVVCLGNICRSPMGEAVLTHVGKERGLDLTVDSAGTSRYHIGEDPDDRTIAACRKHNVPIQHAARQVTEEDFRRFTHILAADEANLHSLEQKKPRNATAEVRLWGSYLDNKPIADPYYGGTRDFEECYQQCVKLSNAFLDEVVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JCX2</accession>
    <name>A0A2H3JCX2_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_20618</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467887">
        <property type="protein sequence ID" value="PCH36579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JCX2"/>
    <dbReference type="OrthoDB" id="2913347at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH36579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="180" mass="19996" checksum="7087501DBEE41D0F" modified="2018-01-31" version="1">MAAIPIVIPPPQLFALPVGTYGVSFDLTPHAMIEDLPNEWNLKGTSRIHEKIAQHFVGRLYSNPQGSVFLRKKYCALLVFMDIMSLRELLPPDDFATVARACQISHIQPIIMDITDDIRLGVQYSPALLGPTPASLVPDTVPHALMDHAPDPLPLDVQPSHAATIGNNWALWRVIFYTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JES6</accession>
    <name>A0A2H3JES6_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">TrkH-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WOLCODRAFT_98812</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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        <source>
            <dbReference type="EMBL" id="PCH37739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="804" mass="85931" checksum="FAEE780E1BC24236" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JGS9</accession>
    <name>A0A2H3JGS9_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">L-tyrosine:2-oxoglutarate aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WOLCODRAFT_141086</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD-104</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467954">
        <property type="protein sequence ID" value="PCH39053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JGS9"/>
    <dbReference type="STRING" id="742152.A0A2H3JGS9"/>
    <dbReference type="OMA" id="FLQYDAP"/>
    <dbReference type="OrthoDB" id="691673at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901605">
        <property type="term" value="P:alpha-amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050859">
        <property type="entry name" value="Class-I_PLP-dep_aminotransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790:SF19">
        <property type="entry name" value="KYNURENINE_ALPHA-AMINOADIPATE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="6">
        <location>
            <begin position="87"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PCH39053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="495" mass="55817" checksum="F2D0EFFC2FE730EE" modified="2018-01-31" version="1">MPPADLLHHLSTEARERKPNLIRDVWKSVKRGSDIVSLANGDPHYTLYPLRRLQYEVPSLCPEDPVSAWRAAHGTATSQTFTSHIDEHCALSIRTALQYSTGAGSTEARESIMEINKYYHNPPNHVVTLALGNADALSKCFRLFGEPGDNFIADEYAFTALTSVAESQGIGWVPVRLDAGGMVPEELHRILLNWDDACGRRPHVIYLVPCGQNPTGSTLSIERRKRIYEIAQEFDLLIIEDDPYYFLQFGSCSPEVTDSSHNLLPSFLSMDEDGRIIRVDSFSKIIAPGMRLGWITSNPAFQPYIIAITDASSQHPHGFGQMFITELLAPTGWQLRGFDKWVHSLRAEYQRQRDFFVKVFHEEVEPSGLAEMQVPQAGMFVWVRVNMEKHSRYRDDLRISARSMEPRTNAKDLMAQLFDYCLDNGVAFMPGSVFALSSHPALLNMDSPVEDRVNYCRMTFSGTQETIQKGLSRFGGALRNFFNLDSLSADAETRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JGX7</accession>
    <name>A0A2H3JGX7_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DUF1777-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WOLCODRAFT_136000</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May play a role in mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of a tri-snRNP complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SNUT3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH38029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JGX7"/>
    <dbReference type="STRING" id="742152.A0A2H3JGX7"/>
    <dbReference type="OMA" id="VDSSTMW"/>
    <dbReference type="OrthoDB" id="21368at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013957">
        <property type="entry name" value="SNRNP27"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31077">
        <property type="entry name" value="U4/U6.U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 27 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31077:SF1">
        <property type="entry name" value="U4_U6.U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 27 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08648">
        <property type="entry name" value="SNRNP27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="U4/U6.U5 small nuclear ribonucleoprotein 27kDa protein" evidence="9">
        <location>
            <begin position="178"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="43"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="143"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="166"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PCH38029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="234" mass="27908" checksum="D3B3204A971D1CEA" modified="2018-01-31" version="1">MSSRHDYRRRDRSHERDDRDARERYGRPRDAPRRSRSRSPPRRGVERDRRPDRRDYARDRERDRRDDRRRDDRDRRDHDRERERDGKKDPPPRDKDRDRGRERERDSERPRERDARPGEHPPERDARPESSRAAAEPDRSRPAPAPASEEPPPARPRQDSEMLVDGPEEGEEMDAANEDDADMMAMMGLSGFGSTKGKHVEGNQEGSVQIKKMRTWRQYMNRRGGFNRPLDKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JHD2</accession>
    <name>A0A2H3JHD2_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UDP-glucuronate decarboxylase</fullName>
            <ecNumber evidence="6">4.1.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">WOLCODRAFT_24859</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>UDP-alpha-D-glucuronate + H(+) = UDP-alpha-D-xylose + CO2</text>
            <dbReference type="Rhea" id="RHEA:23916"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57632"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="EC" id="4.1.1.35"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Nucleotide-sugar biosynthesis; UDP-alpha-D-xylose biosynthesis; UDP-alpha-D-xylose from UDP-alpha-D-glucuronate: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">Golgi stack membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.35" evidence="6"/>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH41600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JHD2"/>
    <dbReference type="STRING" id="742152.A0A2H3JHD2"/>
    <dbReference type="OMA" id="KYPKVKY"/>
    <dbReference type="OrthoDB" id="331544at2759"/>
    <dbReference type="UniPathway" id="UPA00796">
        <property type="reaction ID" value="UER00771"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048040">
        <property type="term" value="F:UDP-glucuronate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033320">
        <property type="term" value="P:UDP-D-xylose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05230">
        <property type="entry name" value="UGD_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000150">
        <property type="entry name" value="UDP-glucuronic acid decarboxylase 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044516">
        <property type="entry name" value="UXS-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43078:SF6">
        <property type="entry name" value="UDP-GLUCURONIC ACID DECARBOXYLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43078">
        <property type="entry name" value="UDP-GLUCURONIC ACID DECARBOXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="15" id="KW-0456">Lyase</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0520">NAD</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="17">
        <location>
            <begin position="101"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00051601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PCH41600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="420" mass="47735" checksum="3E83CED89707E915" modified="2018-01-31" version="1">MSATATQFVMLDKNGQEIKTVGFERFGFDCEAPLDVVRSLYLRPHYVRSANSTSPKPGEQSEEDFQSNSIYYPDTKSISYTTLTRFPPVKLLPPEKRKRVLVTGGAGFVGSHLVDRLMLLGHEVTVLDNFFTGSKTTVSHWVGHPNFELVRHDVVEPYMTECDQIYHLACPASPPHYQFNAVKTVKTSFLGTLNMLGLAKRTKARFLITSTSEVYGDPEVHPQPEDYWGHVNPIGPRACYDEGKRVAETLTYGYHRQNGVDVRVARIFNTYGPRMNPYDGRVVSNFIIQALRGEDMTVYGDGKQTRSFQFIHDLIDGLIALMNSDETRPVNIGNGDEFTIGEFAELVREVVEKVQTEDGEPPKRHVQIVYKPMPTDDPQKRRPDTTRAKQVLDWQPRWSVRMGLEEMVRYYKAKMAEGSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JI91</accession>
    <name>A0A2H3JI91_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">60S ribosomal protein L31</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WOLCODRAFT_29114</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL31 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467931">
        <property type="protein sequence ID" value="PCH37448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JI91"/>
    <dbReference type="STRING" id="742152.A0A2H3JI91"/>
    <dbReference type="OMA" id="EVWKQGI"/>
    <dbReference type="OrthoDB" id="9739313at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00463">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.440.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000054">
        <property type="entry name" value="Ribosomal_eL31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020052">
        <property type="entry name" value="Ribosomal_eL31_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023621">
        <property type="entry name" value="Ribosomal_eL31_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10956">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10956:SF0">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01198">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01380">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54575">
        <property type="entry name" value="Ribosomal protein L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01144">
        <property type="entry name" value="RIBOSOMAL_L31E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PCH37448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="125" mass="14337" checksum="13B4EAFDAECA2CCB" modified="2018-01-31" version="1">MAPKTTTKKTGKTRSALQDVVTREYTIHLHKRVHGRSFKKRAPWAVKSVVAFAQKAMGTSDVRIDPKLNQELWARGIKSVPHRIRIKLERKRNDEENAKEKLFTYASYVIVDSFKGLETTVVDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JIC2</accession>
    <name>A0A2H3JIC2_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_71744</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468124">
        <property type="protein sequence ID" value="PCH41936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JIC2"/>
    <dbReference type="OMA" id="FANQKSH"/>
    <dbReference type="OrthoDB" id="2416294at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH41936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="75" mass="8789" checksum="F02BDF7B87E984FC" modified="2018-01-31" version="1" fragment="single">NCCCHRLLFTQPDFANQKSHLGKYIGSCGHIGDFYPKFQTELNFIEQYWGAAKYHYHISPKASDFNEMDTWTSHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JJ30</accession>
    <name>A0A2H3JJ30_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA binding protein Ncp1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_72099</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468124">
        <property type="protein sequence ID" value="PCH42210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JJ30"/>
    <dbReference type="OMA" id="PILWHES"/>
    <dbReference type="OrthoDB" id="3267800at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="102"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH42210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="369" mass="39445" checksum="FDC90E4792169F2C" modified="2018-01-31" version="1">MHIFTRKSKDKHEHGADGKGTGAVAESAPDADLPLTPGGPDVDRTHQPSVTVAPEPATSSQDAAGDDATEDQQLAGPKLARSQGAVPTADPASDSGYASSASPKSRQRSLSRSSRAGGDMKPIPILWSEGAQPGQRARGADADADADADADSDGVTADNTQRNGEEVRRAATATSPRRRVSLSGGSFAGGPGTIGPASVSQVDTSEFQERSKAAEAELTPKQRSRIDKANAKESKRVARVMRFEAKAEKQAISQAIRELADIQKMQKGAIKEESKAVSAHAKALRDFHKEELDFLAAKAKFDKAQAQLQVYEDARDAARDHAAEITEMLQVKNQEIEWLRAQKAVDDREREAKIKQLTGKSSTWYNIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JJH2</accession>
    <name>A0A2H3JJH2_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">1-phosphatidylinositol 4-kinase</fullName>
            <ecNumber evidence="3">2.7.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WOLCODRAFT_22923</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19877"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.67"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.67" evidence="3"/>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH37888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="742152.A0A2H3JJH2"/>
    <dbReference type="OMA" id="TIEVWQS"/>
    <dbReference type="OrthoDB" id="10264149at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004430">
        <property type="term" value="F:1-phosphatidylinositol 4-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05167">
        <property type="entry name" value="PI4Kc_III_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.70:FF:000011">
        <property type="entry name" value="Phosphatidylinositol 4-kinase alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000012">
        <property type="entry name" value="Phosphatidylinositol 4-kinase alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000014">
        <property type="entry name" value="Phosphatidylinositol 4-kinase STT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.70">
        <property type="entry name" value="Phosphatidylinositol 3-kinase, accessory domain (PIK)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI3/4_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001263">
        <property type="entry name" value="PI3K_accessory_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042236">
        <property type="entry name" value="PI3K_accessory_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045495">
        <property type="entry name" value="PI4K_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048:SF15">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00613">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19274">
        <property type="entry name" value="PI4K_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00145">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51545">
        <property type="entry name" value="PIK_HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIK helical" evidence="9">
        <location>
            <begin position="1386"/>
            <end position="1572"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="8">
        <location>
            <begin position="1673"/>
            <end position="1938"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS37 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468053">
        <property type="protein sequence ID" value="PCH40019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JMI2"/>
    <dbReference type="STRING" id="742152.A0A2H3JMI2"/>
    <dbReference type="OMA" id="QKEVYQR"/>
    <dbReference type="OrthoDB" id="10260857at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043162">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.660">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037202">
        <property type="entry name" value="ESCRT_assembly_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029012">
        <property type="entry name" value="Helix_hairpin_bin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009851">
        <property type="entry name" value="Mod_r"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13678">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13678:SF2">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 37A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07200">
        <property type="entry name" value="Mod_r"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140111">
        <property type="entry name" value="Endosomal sorting complex assembly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51314">
        <property type="entry name" value="VPS37_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="5 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VPS37 C-terminal" evidence="7">
        <location>
            <begin position="71"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PCH40019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="167" mass="19209" checksum="48EF3147908940CE" modified="2018-01-31" version="1" fragment="single">LEELLVDPVYFQAIFHSLDQVKALYQAQAELGSANENIASASLQNNLALQDALYQLRSDTQQAFDEAKSLEARWKEVEKEQKEVYQRFTPQFLLMRLRHATVAQDDISEARAAEFVQASSVEPSNTGANGKDIDDFVREFKELRKVYHKRVMWGDRWAAGQVAWRDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JMI3</accession>
    <name>A0A2H3JMI3_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_25895</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468146">
        <property type="protein sequence ID" value="PCH43406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JMI3"/>
    <dbReference type="STRING" id="742152.A0A2H3JMI3"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="140"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH43406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="169" mass="18727" checksum="A9023BB5135EEB36" modified="2018-01-31" version="1">MLQTSYLTSEAVVLINDYSNSLWNGPTDLLLHDLSTAALDHVPNPVDHGLYHAGSSEASAALETGTACTWDNNSCGSKLTDLTPSGIRRHLKAHHFGDLWNDGQRGICRWLEGGKVCGKELRLANLSKHIASVHMRSTRLQCPRCLRGFSRPDALRRHSQFYCVHLHDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JMJ7</accession>
    <name>A0A2H3JMJ7_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WOLCODRAFT_66856</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH37864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JMJ7"/>
    <dbReference type="STRING" id="742152.A0A2H3JMJ7"/>
    <dbReference type="OMA" id="DCIRRWE"/>
    <dbReference type="OrthoDB" id="4161332at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF26">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    <protein>
        <recommendedName>
            <fullName evidence="3">GDP-L-fucose synthase</fullName>
            <ecNumber evidence="3">1.1.1.271</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WOLCODRAFT_128552</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD-104</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; GDP-L-fucose biosynthesis via de novo pathway; GDP-L-fucose from GDP-alpha-D-mannose: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.271" evidence="3"/>
    <dbReference type="EMBL" id="KB467931">
        <property type="protein sequence ID" value="PCH37537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JNF2"/>
    <dbReference type="STRING" id="742152.A0A2H3JNF2"/>
    <dbReference type="OMA" id="LHTPYQV"/>
    <dbReference type="OrthoDB" id="202470at2759"/>
    <dbReference type="UniPathway" id="UPA00128">
        <property type="reaction ID" value="UER00191"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050577">
        <property type="term" value="F:GDP-L-fucose synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042351">
        <property type="term" value="P:'de novo' GDP-L-fucose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05239">
        <property type="entry name" value="GDP_FS_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00956">
        <property type="entry name" value="GDP_fucose_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028614">
        <property type="entry name" value="GDP_fucose/colitose_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43238">
        <property type="entry name" value="GDP-L-FUCOSE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43238:SF1">
        <property type="entry name" value="GDP-L-FUCOSE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="7">
        <location>
            <begin position="4"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PCH37537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="326" mass="36635" checksum="ACD69CC1B9EF0EBF" modified="2018-01-31" version="1">MSVILVTGGSGLVGKALQHVINTEPVGSRFGRRPDEQWVFVSSSEADLRNAEEARLLFEKYKPTHVIHLAAIVGGVYINMKNNLNFLRDNILINDNVLHTAYQTKVQKVISCLSTCVFPDKVTYPLDETKIHLGPPHDSNFGYSYAKRLVDVQNRAYKDQFGCNFTAAIPTSIFGPYDNFELGSAHVIPALIHKCYLAQKNGTPLVIGGSGKPLRQFIYSYDLAKLFIWQLREYDDVEPIILSVAEDQEVSIKQLAEAIVKAMHFKGVCLFDTNQAEGQFRKPASNAKLMTLIGDFEFTPFEKALDETVQWFLRHYEGARTGKARN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JNN5</accession>
    <name>A0A2H3JNN5_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zinc-ribbon 15 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_149197</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH38254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JNN5"/>
    <dbReference type="STRING" id="742152.A0A2H3JNN5"/>
    <dbReference type="OMA" id="PLIPMKS"/>
    <dbReference type="OrthoDB" id="5545479at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28139">
        <property type="entry name" value="UPF0768 PROTEIN YBL029C-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28139:SF1">
        <property type="entry name" value="UPF0768 PROTEIN YBL029C-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH38254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="130" mass="14674" checksum="C0F0E2514D2AC440" modified="2018-01-31" version="1">MDFIFCLPIIFGCPTKIKPDGDQSPRICPRCNNASVTSAKSRLWFELCFVPLIPMRSKRVWVCCICQWSIPLQPGWEPAIAGNNFQQGRPWQQQPPSGYMGAPPNTYQPGYQPGYINQNQGQKLEGPTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JNU7</accession>
    <name>A0A2H3JNU7_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_164287</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468135">
        <property type="protein sequence ID" value="PCH43165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JNU7"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH43165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="98" mass="10344" checksum="F9063E34C15F57D2" modified="2018-01-31" version="1" fragment="single">MAALNERSFVIDLRGSAALCHTKPCTLSLWDPSQNCLARSINEALWQPPVRGAHTSVPHRPTAAQRSPTRSPSYPGPAASAKLLRGHPGGQAVPARGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JPL7</accession>
    <name>A0A2H3JPL7_WOLCO</name>
    <protein>
        <submittedName>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </feature>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH41853.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="103" mass="11644" checksum="55A4720F8795641B" modified="2018-01-31" version="1">MEQNDEQIAKMPQLMMVVEDQPIIELKDLGEDQWWKTEWPTSEGDALRTPFAGKKRPQEEREEQRNEDSSQSGSSSKGDGGKDGDEDEEEEEEEEEEGGGGGR</sequence>
</entry>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD-104</strain>
        </source>
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        <location>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
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        </source>
    </evidence>
    <sequence length="313" mass="34395" checksum="85CD059B3E1E9005" modified="2018-01-31" version="1">MPSKPIVLVVGATGATGRPITEVLLESVEFARSHWYVNVAVLTRPSSVSKPEVEALRAKGAEIRTADIHSDSVEVLMEAVSGVDILISAANAMAILAQKPLFSAAKAAGVKHVVPCDFATPGKLEVRDCVKELGLGYTFIDIGWWHQGYLPSSTNSPSILGPMSHEIYGDGNRKNLLTDVEHLGMYVARIVGDERTLNQNVIVWEDEKTLLEAQEIGERISGESNLIRSKRTNVTYEELVARAKAGKEAYQRSHSYTDLQLLGVSEYMISMHILGENTLENAKALGALNVRELYPDIKPVTLEEYAKRFYKTA</sequence>
</entry>
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    <accession>A0A2H3JQV3</accession>
    <name>A0A2H3JQV3_WOLCO</name>
    <protein>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Barry K."/>
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                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
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                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
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                <person name="Ferreira P."/>
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                <person name="Heitman J."/>
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                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
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                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
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                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
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                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
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                <person name="Wiebenga A."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH39044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="103" mass="11668" checksum="F486D4D1A51BD241" modified="2018-01-31" version="1">MHPHLRAPQERKPRSLSVEPGTSRQTRRATIVIVLQTCHWLGYAVAEVTSPREEIGQEANRIVLVLVPGTTSQSMDDFLAERAELAAGVLSRHYFTFIMDLRR</sequence>
</entry>
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    <accession>A0A2H3JQX8</accession>
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            <fullName evidence="7">Fms interacting protein</fullName>
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            <taxon>Phaeolaceae</taxon>
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        </lineage>
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    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
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                <person name="Carlson A."/>
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                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the THOC5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH41209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JQX8"/>
    <dbReference type="STRING" id="742152.A0A2H3JQX8"/>
    <dbReference type="OMA" id="HKYMKLP"/>
    <dbReference type="OrthoDB" id="20582at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019163">
        <property type="entry name" value="THO_Thoc5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13375">
        <property type="entry name" value="FMS INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13375:SF3">
        <property type="entry name" value="THO COMPLEX SUBUNIT 5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09766">
        <property type="entry name" value="FmiP_Thoc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="149"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PCH41209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="215" mass="24247" checksum="0C32DCB2DCC47BEE" modified="2018-01-31" version="1">MAIEDLDVAVPLPPSPDAVIDRLRDLVSSSYLNHDPAAVNIRAGALFARLKALNRAANGATRAHKQATADARHDMDQTYLGLQNLLYEKRHLEREIEKCRQFASVYQDIPLYTLEEFIQYAPEEARTEAVLADEHQLMLNRLSFELAERQRLDQRQKELIRLKEELIKESKAKLATMDSVKAQIDSLIKTATEVQKKVGDLVQPLPSAEPTPAPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JQY8</accession>
    <name>A0A2H3JQY8_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Saccharopine dehydrogenase [NADP(+), L-glutamate-forming]</fullName>
            <ecNumber evidence="10">1.5.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Saccharopine reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">WOLCODRAFT_85122</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-saccharopine + NADP(+) + H2O = (S)-2-amino-6-oxohexanoate + L-glutamate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57951"/>
            <dbReference type="ChEBI" id="CHEBI:58321"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (fungal route): step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the saccharopine dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 14">Belongs to the spermidine/spermine synthase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.10" evidence="10"/>
    <dbReference type="EMBL" id="KB467954">
        <property type="protein sequence ID" value="PCH39084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JQY8"/>
    <dbReference type="STRING" id="742152.A0A2H3JQY8"/>
    <dbReference type="OMA" id="ECLWIHL"/>
    <dbReference type="OrthoDB" id="10059875at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004755">
        <property type="term" value="F:saccharopine dehydrogenase (NADP+, L-glutamate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006596">
        <property type="term" value="P:polyamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000008">
        <property type="entry name" value="Alpha-aminoadipic semialdehyde synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000072">
        <property type="entry name" value="Saccharopine dehydrogenase [NADP(+), L-glutamate-forming]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1870.10:FF:000002">
        <property type="entry name" value="Saccharopine dehydrogenase Lys9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.140.10:FF:000001">
        <property type="entry name" value="SPE3p Spermidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000013">
        <property type="entry name" value="Spermidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1870.10">
        <property type="entry name" value="Domain 3, Saccharopine reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.140.10">
        <property type="entry name" value="Spermidine synthase, tetramerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00198">
        <property type="entry name" value="Spermidine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051168">
        <property type="entry name" value="AASS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030374">
        <property type="entry name" value="PABS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030373">
        <property type="entry name" value="PABS_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032095">
        <property type="entry name" value="Sacchrp_dh-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001045">
        <property type="entry name" value="Spermi_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035246">
        <property type="entry name" value="Spermidine_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037163">
        <property type="entry name" value="Spermidine_synt_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002010">
        <property type="entry name" value="PRK00811.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00417">
        <property type="entry name" value="speE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133:SF22">
        <property type="entry name" value="ALPHA-AMINOADIPIC SEMIALDEHYDE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16653">
        <property type="entry name" value="Sacchrp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17284">
        <property type="entry name" value="Spermine_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01564">
        <property type="entry name" value="Spermine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01330">
        <property type="entry name" value="PABS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51006">
        <property type="entry name" value="PABS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PABS" evidence="15">
        <location>
            <begin position="11"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00060549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00066976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00067598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00083134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PCH39084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="748" mass="82118" checksum="2F960B3F5B577688" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JR35</accession>
    <name>A0A2H3JR35_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WOLCODRAFT_104481</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
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            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <location>
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    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="420" mass="47428" checksum="CC54BCDE8969F8A7" modified="2018-01-31" version="1" fragment="single">LIRNAHLEDDIKDTAILHHIHNPPQQPFNTDDPIKVLSVEICLGLNYCSWKTYDHFRSALLCCPPHLELLSYCVIKSYVDYVENLTGIFSLYHNCCVNSCMAYTGIYSDLDKCNYCNELCYEEQKCRRKCRCVLRKQSTTIPICSSAQPCRNNKKGSRAAEYHATATRQALASLQETNGKLEKISDYIYGKDYLEAVICSDIKDEDTCLMFSIDGAQLYASKLSDCWMFIWVLLDYAPDVHYRKTHIMPAGFIPGPNKPKNIDSFILPSLPHVASFMGQHEKLKIWCEQHGLYESKLYIVVGAADCPAMTYLNGTVGHSGAQGCRLYCPLKGHCKPGRSHYYPACQLSHNYSVPNCTHPDISLCDAILDSEEASSHYYANLECLLNALTQHEYEKIRLETGICKPSLFGGFPTDCFLGIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JS95</accession>
    <name>A0A2H3JS95_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_51651</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468168">
        <property type="protein sequence ID" value="PCH45016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JS95"/>
    <dbReference type="STRING" id="742152.A0A2H3JS95"/>
    <dbReference type="OMA" id="FPWTSIR"/>
    <dbReference type="OrthoDB" id="2768905at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH45016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="201" mass="22730" checksum="0F2339142BF945D6" modified="2018-01-31" version="1" fragment="single">IAAATTPAPARKEKVPPPPEFSGADGKVQAKEWIEKLGLYFAKVKPADDKERITTALYRLSGEAYRFMGPMLEKAGNGEPLGTWNDFKKQILNQYAKKTDKEIAEKEIKAFYGTSGKKKVETNFFTYCSKFRTLGRLSEIDGTTLLREFKEVLPEKVRDHVAILTRVTPAAIPADWDKYVDLCLELYKIAYPDRLDGSIFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JSM2</accession>
    <name>A0A2H3JSM2_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">HATC-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WOLCODRAFT_124595</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB468168">
        <property type="protein sequence ID" value="PCH45150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JSM2"/>
    <dbReference type="STRING" id="742152.A0A2H3JSM2"/>
    <dbReference type="OMA" id="XERAPST"/>
    <dbReference type="OrthoDB" id="3062869at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="6">
        <location>
            <begin position="108"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PCH45150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="190" mass="21462" checksum="4BAC0BD47AE53734" modified="2018-01-31" version="1" fragment="single">MLLDPNQKKSHIQRHWGDELLQQALKHAETIYAARYKKLYPDGIVMTRIKRTASATSAAGRVKRLIDCELSDDEDNLSETGISDDVDPVKPWLHDFHGYLDSVDDLGHCSIVQWWGLNAGRYPVWASLARDYLAVMASSVSSERAFSSAGITISKRRNRLKADIVEALQFLKCAIRRDLLFCESPSLLTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JSR6</accession>
    <name>A0A2H3JSR6_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10">Peroxisomal membrane protein PEX14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 10">Peroxin-14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">WOLCODRAFT_162568</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor. The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm. Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9 10">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the peroxin-14 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH40818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JSR6"/>
    <dbReference type="STRING" id="742152.A0A2H3JSR6"/>
    <dbReference type="OMA" id="FRFIYPR"/>
    <dbReference type="OrthoDB" id="441517at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990429">
        <property type="term" value="C:peroxisomal importomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016560">
        <property type="term" value="P:protein import into peroxisome matrix, docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025655">
        <property type="entry name" value="PEX14"/>
    </dbReference>
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        <property type="entry name" value="Pex14_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23058">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23058:SF0">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04695">
        <property type="entry name" value="Pex14_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="3 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0811">Translocation</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Peroxisome membrane anchor protein Pex14p N-terminal" evidence="13">
        <location>
            <begin position="40"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00029502"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00029691"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00046271"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU367032"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF04695"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH40818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="397" mass="44087" checksum="7B6A68C67D71C8E4" modified="2018-01-31" version="1">MAIEQQSAPPESTSEAVHDPGTDGNATATSTTPDESGTVDRTELLKKARAFLTSPQVRYEDASSKRTFLSEKGLNDLEIENLLQEVPQQPPLIPPRTYPQPPPSDLPTLLLGIARIFSWLAGGSAALLFVYFRFLYPRIEQTFKARHALRIHRRELLLKFTESLKSLKETHAETAAVLPRPRPATHEDEKFSKYTTLDDLCGAQDAPPVTLLRCVLASLAASNTAPTAAAIFAALETKYSWLRTDSYVGEQRQEELWRVLTSTPHLFHCIDESSEDPHWVYTAPELIDERSYNGSTLSSLSSLKHALEKAAQREQTRYQGLLDTLSELTGYVASRTYMVTSSFGQIYGAVQLSPEEEDVRREIRALKGLVLNRRTFIPPVARPPSVSIAPPETPGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JSU9</accession>
    <name>A0A2H3JSU9_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_31931</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468135">
        <property type="protein sequence ID" value="PCH42993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="3261594at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH42993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="421" mass="47299" checksum="FEAB096519701DA7" modified="2018-01-31" version="1" fragment="single">LKDLRDTVDMQHLLRNSRLEDEITDPGVLEHIRNPPTKLVNIDDPVITLSIEVYLGLDYVAQEYYNLVHRAVAQCPPHIEMLSFSEVKAKVAEITGIIALKHDVCISSCMAFTGIYSDLLICSYCGENRYVEKRVRRKCVNVPRKQMTTIPIGLVLQAMRHSVVSSEGANYHSKITRKVLRSLLANDSIIQEYTDFVHGEDYLNACDKGDIGDDNIVLMFSMDGVQLYACKQSDCWVYMWVLLDYVPEVRYKKTHVIPGGIIPGPNKPKNVDSFIFPGLHILSSHMIEGLKIWDPRRGIILFVLLTTADSVGMTYLNGLVGHSGAQGCRIYCPLKGRHKPGSGYYYPACLKPDNYDVANCSHEDVELQILDSASKRYYDNLTCMLGVRTDREFQKLHLETGIAKPSLFGGLPLRSTLGLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JT13</accession>
    <name>A0A2H3JT13_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WOLCODRAFT_103068</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB468135">
        <property type="protein sequence ID" value="PCH43093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="742152.A0A2H3JT13"/>
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    <dbReference type="OrthoDB" id="3364175at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF87">
        <property type="entry name" value="COL-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="22"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="57"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PCH43093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="833" mass="91755" checksum="E5D6281905C9BA40" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JTA4</accession>
    <name>A0A2H3JTA4_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">WOLCODRAFT_105643</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoplasmic ribonucleoprotein granule</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA2/NAM7 helicase family. SDE3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="3"/>
    <dbReference type="EMBL" id="KB468168">
        <property type="protein sequence ID" value="PCH44785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JTA4"/>
    <dbReference type="STRING" id="742152.A0A2H3JTA4"/>
    <dbReference type="OMA" id="HINTIAG"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036464">
        <property type="term" value="C:cytoplasmic ribonucleoprotein granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032574">
        <property type="term" value="F:5'-3' RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18038">
        <property type="entry name" value="DEXXQc_Helz-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000608">
        <property type="entry name" value="Mov10 RISC complex RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049080">
        <property type="entry name" value="MOV-10-like_beta-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026122">
        <property type="entry name" value="MOV-10/SDE3_DEXXQ/H-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45418">
        <property type="entry name" value="CANCER/TESTIS ANTIGEN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45418:SF1">
        <property type="entry name" value="CANCER_TESTIS ANTIGEN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21634">
        <property type="entry name" value="MOV-10_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 16" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0943">RNA-mediated gene silencing</keyword>
    <feature type="domain" description="Helicase MOV-10-like beta-barrel" evidence="15">
        <location>
            <begin position="376"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="13">
        <location>
            <begin position="509"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="13">
        <location>
            <begin position="620"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="14">
        <location>
            <begin position="701"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="978"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="990"/>
            <end position="999"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF21634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PCH44785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="999" mass="111691" checksum="C029676150A153ED" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JTN0</accession>
    <name>A0A2H3JTN0_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Thiamine pyrophosphokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WOLCODRAFT_137798</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468124">
        <property type="protein sequence ID" value="PCH42259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JTN0"/>
    <dbReference type="STRING" id="742152.A0A2H3JTN0"/>
    <dbReference type="OMA" id="HHLYMMT"/>
    <dbReference type="OrthoDB" id="25149at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030975">
        <property type="term" value="F:thiamine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004788">
        <property type="term" value="F:thiamine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006772">
        <property type="term" value="P:thiamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07995">
        <property type="entry name" value="TPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.320:FF:000001">
        <property type="entry name" value="Thiamine pyrophosphokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10240">
        <property type="entry name" value="Thiamin pyrophosphokinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.320">
        <property type="entry name" value="Thiamin pyrophosphokinase, thiamin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006282">
        <property type="entry name" value="Thi_PPkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007373">
        <property type="entry name" value="Thiamin_PyroPKinase_B1-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036371">
        <property type="entry name" value="TPK_B1-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007371">
        <property type="entry name" value="TPK_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036759">
        <property type="entry name" value="TPK_catalytic_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01378">
        <property type="entry name" value="thi_PPkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622:SF8">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04265">
        <property type="entry name" value="TPK_B1_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04263">
        <property type="entry name" value="TPK_catalytic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00983">
        <property type="entry name" value="TPK_B1_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63999">
        <property type="entry name" value="Thiamin pyrophosphokinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63862">
        <property type="entry name" value="Thiamin pyrophosphokinase, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiamin pyrophosphokinase thiamin-binding" evidence="5">
        <location>
            <begin position="269"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PCH42259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="349" mass="38426" checksum="8FCD3465887A740B" modified="2018-01-31" version="1">MPDLVRVAATLSATADAPGAMSRTGSTPVSGPSSLSLRRAGVWTMWYKGEKSEAWIAATARVPKRIAHVRVCDAFTRRPISPDRICSTMSTSESVCWTIPFLEPPSTYHAHDRKYALIILNQPFSRALLSRLWTAGAWRCCADGGANRLHDALGSSSGQDARAMYIPNLIKGDLDSLRSDVREYYASQNVPVVQDNDQYSTDLMKCIHALEEHETATGSNTLELIILGGLSGRLDQTVHTLSLLHKLRKGKRRIYVASDDNVAWVLGEGEHSIEINHAVFGPTCGLLPVGIDATVLSTTGLRWNLADTHSSFDTVVSTSNHFVPEERTVWIKTTKPVWWTMEVRAEGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JUA9</accession>
    <name>A0A2H3JUA9_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_149758</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468053">
        <property type="protein sequence ID" value="PCH39717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JUA9"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH39717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="403" mass="44465" checksum="B5798DCDC579D580" modified="2018-01-31" version="1">MADNSWEDEGNLEHAKDLLKAYHRSQVRTAPQLETHTVITCRRVALTEPLLWPTTEVHDRPETKMEEGSQEVCHRYHDLPTICKSSTPSSGIGPRDLLLAEPMAGLTSSTLPRISRTSTTNISTSPRISYAWRGRCTDRGETSENSSTGLSTDWPPPHPRGSDTPSTTSRIESTLHQIDPRTPLDLPGYSPMMNTAESQARSILWQVIEYYFGSLPCLSLPDEQELERRQNVFLVWEAMGDVNHLHARQVLGLPQHTTTEAIVQRLFLELHQSRSLPTRSTSELQGNTSATPPPYPDGPFRTSSERTTMNSTGGTSTSEISLPSGYQRGPLPNNCADSVGQTPTGSSTVQTIFAGLVASINQVIDRVNAAPIRPAELQRPLPSAGMETSIMNRIPRPSSRDDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JV64</accession>
    <name>A0A2H3JV64_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA repair protein RAD50</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">WOLCODRAFT_162047</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SMC family. RAD50 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB468053">
        <property type="protein sequence ID" value="PCH40037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="742152.A0A2H3JV64"/>
    <dbReference type="OMA" id="FSDYYYR"/>
    <dbReference type="OrthoDB" id="18797at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030870">
        <property type="term" value="C:Mre11 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003691">
        <property type="term" value="F:double-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051880">
        <property type="term" value="F:G-quadruplex DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043047">
        <property type="term" value="F:single-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070192">
        <property type="term" value="P:chromosome organization involved in meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000722">
        <property type="term" value="P:telomere maintenance via recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007004">
        <property type="term" value="P:telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000947">
        <property type="entry name" value="DNA repair protein RAD50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001195">
        <property type="entry name" value="DNA repair protein rad50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038729">
        <property type="entry name" value="Rad50/SbcC_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004584">
        <property type="entry name" value="Rad50_eukaryotes"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00606">
        <property type="entry name" value="rad50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18867:SF12">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18867">
        <property type="entry name" value="RAD50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13476">
        <property type="entry name" value="AAA_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13558">
        <property type="entry name" value="SbcC_Walker_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="11 15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Rad50/SbcC-type AAA" evidence="16">
        <location>
            <begin position="6"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="194"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="273"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="436"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="573"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="698"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="770"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="910"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="978"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="1083"/>
            <end position="1110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
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                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468167">
        <property type="protein sequence ID" value="PCH44613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JXA3"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH44613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="168" mass="19013" checksum="E4D6D646444A6A8A" modified="2018-01-31" version="1">MSPDREGIRIRRIRSGTRCAVPKYSHFFPFTPPFLFARIHHLPLFTRIDMSKLPASSAALPIEHQLDHSRPTKVRRTSAVPLTEPPSHPQPTKTRTPHRKETSLNTVAPSATPRAKKRKYAQSRMPAQLPVTSDHVTTGRTLELRVIKLTSIPCPDSTDSRDRTSLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-05-03" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JXB3</accession>
    <name>A0A2H3JXB3_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_139100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468168">
        <property type="protein sequence ID" value="PCH44623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JXB3"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH44623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="93" mass="9993" checksum="1CD256381B069A2A" modified="2018-01-31" version="1">MTCSPDWYYLIADCAIKCPSSNGSGTSSQSSRVVLGLIERGHQMVPVCVVRSLLSLISLVSAGFSRGSCPLESGRLRSQLECCLGETNRRVNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JY16</accession>
    <name>A0A2H3JY16_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PRA1 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WOLCODRAFT_164733</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Membrane</location>
            <topology evidence="1 5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PRA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468146">
        <property type="protein sequence ID" value="PCH43799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JY16"/>
    <dbReference type="STRING" id="742152.A0A2H3JY16"/>
    <dbReference type="OMA" id="PWTVFFN"/>
    <dbReference type="OrthoDB" id="63113at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004895">
        <property type="entry name" value="Prenylated_rab_accept_PRA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19317">
        <property type="entry name" value="PRENYLATED RAB ACCEPTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19317:SF0">
        <property type="entry name" value="PRENYLATED RAB ACCEPTOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03208">
        <property type="entry name" value="PRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="58"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PCH43799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="164" mass="18004" checksum="99F8C148BBF49D8F" modified="2018-01-31" version="1">MEVLLRVTDTVKSFRETRLSALRPVTEFFDFNRVSRPADLNTATTRISYNTRYFSGNYGVIIAILAVYAVLTNPLLLIALAFLIGGFAAINKFAPEPMQLGEHVVTQKSLYTGLFVIGIPLLWFASPVSTFFWLVGASSVLILGHASLLEPGIESEYTAVGEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JYZ6</accession>
    <name>A0A2H3JYZ6_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative opsin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WOLCODRAFT_100409</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM208 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH41367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JYZ6"/>
    <dbReference type="STRING" id="742152.A0A2H3JYZ6"/>
    <dbReference type="OMA" id="GRPKYDA"/>
    <dbReference type="OrthoDB" id="10012212at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006624">
        <property type="term" value="P:vacuolar protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008506">
        <property type="entry name" value="SND2/TMEM208"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13505">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13505:SF7">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05620">
        <property type="entry name" value="TMEM208_SND2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="150"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="163"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PCH41367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="185" mass="20720" checksum="918647AD3B601BC5" modified="2018-01-31" version="1">MANASAKRVAQQNAETIKNLRNGMLGAGALSVLLRLLLRKGSLSPSRFSFWLLVLSYLPSIFLSRYLERIGSPRRDPTTGTLISAGEDLARPGIIEWAFDVIYITWACQVGSGAFGEWFWWLYLVIPLYAAYKLWSKAISPMLLGRSSASESQADAPQKPLSKRQEKLQKRSERGDARVRTKTVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JZ11</accession>
    <name>A0A2H3JZ11_WOLCO</name>
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        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WOLCODRAFT_163046</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD-104</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
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        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF51">
        <property type="entry name" value="NUCLEOLAR PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
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    </dbReference>
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    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="106"/>
            <end position="194"/>
        </location>
    </feature>
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        <location>
            <begin position="236"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PCH41387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="325" mass="35393" checksum="117449C241589EF4" modified="2018-01-31" version="1">MGRYRCPDSSDSETYDNIPIRLASMTISQDWPAPDMAGPSSSCQIIDLTRPPDKIRTGKIKDKGKGKMRDKGKVGATLKQRERVRMARKQERVRSASDGKRTANYSFVFVGNLDRSISREVLEQHFRRCGQLYRVTIRTAGGSPDARVPAHANGTADRLYASVEFRDAQAAARALKFDGATIRERKIVVSLNAADLPEIKGVGDPPKKKPAVNLHQPFDVKRAFVDLKRITVDKTHYNPATQQAGPSRPGPSRAQAGPSSHFAPSPAGPSRAVAHHADAPRAGPSGRRYQSPIVISDSPPATAHAQPRHLARTTALGVSFPLTLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K0I0</accession>
    <name>A0A2H3K0I0_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein S5 domain 2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WOLCODRAFT_138463</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Agaricomycotina</taxon>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS9 family.</text>
    </comment>
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        <property type="protein sequence ID" value="PCH43608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OMA" id="ARVWVIA"/>
    <dbReference type="OrthoDB" id="10254627at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000754">
        <property type="entry name" value="Ribosomal_uS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020574">
        <property type="entry name" value="Ribosomal_uS9_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569">
        <property type="entry name" value="RIBOSOMAL PROTEIN S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US9M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00380">
        <property type="entry name" value="Ribosomal_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00360">
        <property type="entry name" value="RIBOSOMAL_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PCH43608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="349" mass="38470" checksum="2939ABF7D86C603B" modified="2018-01-31" version="1">MNVARNAISAAVRARTYATMYVPPAALENIIERRHPRKPAPESPNFYTGRAAYFDQVNALESAIQHTRSALQTLELLPLPVFARESIPPAHNVWMTKEALADKLNARLTTSRYRRLLGLLNQLDSYRRIADVAGVVQLAERVADVLQIFERENKAAVLAQGKRKPVQFDQYGRSYTIGRRKESTARVWMIPVQRKEAAADASTSAALAAPEGLEAQTADSLPPLESSVTSAFDDAPVAPVEVTTSNILINNTPLVQYFPLLTDRERIIRPFRIAGLIGAYNVFALVRGGGTTGQSGAVSLGVAKALAAHAPDVEPLLKKAKLLRRDPRMVERKKTGRAKARKAYTWVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K0N9</accession>
    <name>A0A2H3K0N9_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF4139 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WOLCODRAFT_163894</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
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            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
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    <name>A0A2H3IW16_WOLCO</name>
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        <submittedName>
            <fullName evidence="12">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WOLCODRAFT_94965</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD-104</strain>
        </source>
    </reference>
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            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
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            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
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        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
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            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
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    </feature>
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        <location>
            <begin position="460"/>
            <end position="483"/>
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    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="13"/>
            <end position="487"/>
        </location>
    </feature>
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        <location>
            <begin position="510"/>
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        </location>
    </feature>
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            <begin position="516"/>
            <end position="540"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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                <person name="Barry K."/>
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                <person name="Martinez A.T."/>
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        <property type="protein sequence ID" value="PCH37042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J465"/>
    <dbReference type="OMA" id="PANEITQ"/>
    <dbReference type="OrthoDB" id="3238099at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH37042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="477" mass="54620" checksum="2690F958012229C7" modified="2018-01-31" version="1">MKRQLNLSLAPPEIWQKIVNELPTRDKRHCLQISRFFRELAIRTLFAKIHVHFGVDPYLEDYETDDDASLHALRHTRLSMTWDILQRIIHDSAFAAVVTSVVVYSYSQCLGLFEQRTLCQALVRLHGLQALSWHGDKPGPANEITQTLANSCPFLRELAVPLSSSLRLPLPGLKRLRSLQLYRTESLLEPNHESESLVIREAIRSNQQTLRKLQIQGQDLRHIPPSELGHLTELTIMDIGGARLGEIVSSLVHLQFLSVEPDLFIEGGVFDAFAKKPSSLPRLRTLKVMGATDAYHRFNGSEIAILAQFLEKRVSMRRLDVCIACDWEDLAPLLHVLPGLKDLTVLGMHFRTDKLTHEIANQLRHFIPRRTNALRLSMSTTNNADRGVVLELLSALTMLEFVYLRGWPPPRLTVEEIAKAAQRVKLAGLNGRFYHIERSERVHISSPWSAHKTYYREAGDFGCEDWEWLMRHYYLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J4I0</accession>
    <name>A0A2H3J4I0_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WOLCODRAFT_46437</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB467887">
        <property type="protein sequence ID" value="PCH36575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J4I0"/>
    <dbReference type="OMA" id="AHHCHED"/>
    <dbReference type="OrthoDB" id="2798374at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PCH36575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="75" mass="8885" checksum="90BBFAE0CCF8A741" modified="2018-01-31" version="1" fragment="single">LDDLDILHRTKISKLIHKYYQEEHARIIHEAQHALGHISFTSDLWTDAQQRGYMAITLHFCAKDTHQRLNLHARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J622</accession>
    <name>A0A2H3J622_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WOLCODRAFT_87539</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH37680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J622"/>
    <dbReference type="STRING" id="742152.A0A2H3J622"/>
    <dbReference type="OMA" id="RGEAFQM"/>
    <dbReference type="OrthoDB" id="8964853at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00083">
        <property type="entry name" value="bHLH_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10328:SF3">
        <property type="entry name" value="PROTEIN MAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10328">
        <property type="entry name" value="PROTEIN MAX MYC-ASSOCIATED FACTOR X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0010">Activator</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="8">
        <location>
            <begin position="86"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="322"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="142"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="83"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="343"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="389"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PCH37680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="450" mass="46003" checksum="44CD6D2B39BEEE84" modified="2018-01-31" version="1">MAMALPLAIPSSPHAGTASPSSTDGSNGPHTPASPSNPPTLALPPPSDNAAAAAAAAAKETVTTPTSAVPGGGSKRKPSRRANTAERRATHNAVERQRRETLNGRFLDLAALLPNLSQIRRPSKSSIVNSSIAHIHAARRHRLVAARELRLLKLEADALRRELNEWRDRSGLPRVEEPVRGEAFQMVLSGEVEVLAGPVEEDDGAEYGDGDYGDDEYVGAPGPLAEPVEEMRGPLAHAAAVALLSQKPGADAFGPGGGLHLQTMLPARHGAAPMIVSSPTSVSFENPAMAAMYDTPHAIGAPGGFFAHGGFAGADEKPAAWHGPMYPSIPSAGGAPFSPPPGTAQQQQQQQQHGAWARGQGHMFGSPADGDDASSVGSAPRRERSGSMGSTGSGYGAGSPGAGAYDLGRRGAAFGEMGMGGMGLGVGPTVMMKSASMGGGNAHGYAAMML</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J6D5</accession>
    <name>A0A2H3J6D5_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Molybdopterin binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_29135</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467931">
        <property type="protein sequence ID" value="PCH37481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J6D5"/>
    <dbReference type="STRING" id="742152.A0A2H3J6D5"/>
    <dbReference type="OMA" id="MARMPRG"/>
    <dbReference type="OrthoDB" id="448496at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047884">
        <property type="term" value="F:FAD diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042726">
        <property type="term" value="P:flavin-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00885">
        <property type="entry name" value="cinA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="entry name" value="MoaB/Mog-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056596">
        <property type="entry name" value="FLAD1_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47675">
        <property type="entry name" value="MOLYBDOPTERIN BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47675:SF1">
        <property type="entry name" value="MOLYBDOPTERIN BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24102">
        <property type="entry name" value="FLAD1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="Molybdenum cofactor biosynthesis proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoaB/Mog" evidence="2">
        <location>
            <begin position="54"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH37481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="312" mass="34058" checksum="866AE456EFBD7C42" modified="2018-01-31" version="1">MSQTSVPADPSAAPSTVASKSAAEDALKPTEWNFPLSPVPDNPLGEGRYIKEAAALIIGDEILNGKTLDRNSNYFARFCFENGIDLKRIEVVPDEEGDIIEASRRLVDKYDFVITSGGIGPTHDDITYASLAKAFGQPLAHHAETLARMTAMSRHRADIMNQTAEQREARERMALFPVDAEALYIAPDIWVPVVRLAGKLCVFPGIPRLFQRMLDGLKPYLPLPPPHERPFRLQVFTSIPESSIAPYLTELQARTKAAGVRVGSYPLLQRGVYVSLIGKEEAAIRALAAEAAGALNGRVVTPEEAEKEKAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J793</accession>
    <name>A0A2H3J793_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WOLCODRAFT_140906</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. Epoxide hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467931">
        <property type="protein sequence ID" value="PCH37515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J793"/>
    <dbReference type="STRING" id="742152.A0A2H3J793"/>
    <dbReference type="OMA" id="PVYFAAC"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43329">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="29"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PCH37515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="329" mass="36851" checksum="6260557ADA7F5F4E" modified="2018-01-31" version="1">MDASFYKELTTTRHIKYRYFAAPGDATLPTLFFLHGFPSTSYDWRHQVAFFRAQGYAVIAPDLLGHGGTFRPSDPMYYKYSAMSSDLIEILDAEHVDKAIAIGHDWGSTMTARLASYYPDRFSGFAFLAVGYAPTFEGFDYEAVMAQIKQALGYETYGYWQFFGEDNADQVIKAHIDSFISIIFPTDPEVWKTDLCPRGGIKAWLLADKTTPLPSYLTEEDKAIITKSWLSGGLGGALNWYRTLLTGINPEDDKKINSERHVLRHPAFFGACKKDYVCTPALALAAMEPACPNMTVREFNTGHWVQLEAAAELNAALLAWITGILQARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J7L6</accession>
    <name>A0A2H3J7L6_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">UEV-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WOLCODRAFT_142462</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ubiquitin-conjugating enzyme family. UEV subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH38230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J7L6"/>
    <dbReference type="STRING" id="742152.A0A2H3J7L6"/>
    <dbReference type="OMA" id="YMNFPQP"/>
    <dbReference type="OrthoDB" id="306304at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072666">
        <property type="term" value="P:establishment of protein localization to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043162">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11685">
        <property type="entry name" value="UEV_TSG101-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
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    <keyword evidence="5 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
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    <feature type="domain" description="UEV" evidence="10">
        <location>
            <begin position="6"/>
            <end position="151"/>
        </location>
    </feature>
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            <begin position="328"/>
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        </location>
    </feature>
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            <begin position="148"/>
            <end position="239"/>
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    </feature>
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            <begin position="154"/>
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        </location>
    </feature>
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            <begin position="221"/>
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        </location>
    </feature>
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            <dbReference type="ARBA" id="ARBA00004177"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00644"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51312"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51322"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH38230.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="406" mass="44188" checksum="F5416E46F404790C" modified="2018-01-31" version="1">MSSHESLTHRWLRQNIHPYVHPDAVWAHVTALLDRHRTVRPKTDVYTFDDGRTQLLLCLHGLLPIAFRGAAYHIPVAIWLPRDYPRRPPLVYVVPTSDMLVRPGPDMDPSGMCRIDYLRNWEAKSEGCSLAALAQAMQDAFSRAPPVYAKPAPGATPGPRSAPAPASPAPADYSARPPPPLPGAHGQHASQTAPPASPAARNDDRPPLPAKPGASAVTPVAHSTASSPASQTSSRTESPDILGTVRGELASLQHAMALDAERLRAHQADLLAGAPAVRDEMARLEAVRDVCRTVAARVRAVVDAGARSAAELRRKGDPEVDELVCSTTIVHNQLINLVAEDNAIEDTVYHLHRALNTGRIDLERFIRTTRVLAEEQFMKRALIEKIQAGLPGDDPELGWTTPVEWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J7T6</accession>
    <name>A0A2H3J7T6_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ICE2-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_112317</name>
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    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:septin ring assembly"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Ice2"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN ICE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31726:SF2">
        <property type="entry name" value="PROTEIN ICE2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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            <end position="42"/>
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    </feature>
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    </feature>
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            <end position="348"/>
        </location>
    </feature>
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        <source>
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        </source>
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        <source>
            <dbReference type="EMBL" id="PCH33698.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="363" mass="39928" checksum="A81CD02B2AEF8815" modified="2018-01-31" version="1">MGITGHRLLWSAVANTARLSTVTQILVFLPLTLSTLSTPAFLTLSLLLTAHALVHGTLVLLWGTPALSLLQVPMHPFLLLVCFNLFAQRVHPALATAAYLWGKLLRWSSPAIIALEGLSSLLIAQKLGQFGRELVSEGEVYQFGLLVAAAAAYVTSAWWIVVAYPAAATSPLESTLLGVALTTFIFLTLIGFVLRRTNVVESSGLALFVAYNVWQCGFDQSSFSDPSSSYAPLLSNIVPHLQTLINFVTNTLPKPVLFALLYRLVVLHFASQILPTIGADSWEDESGVDDSWDGRPTSRLTHILLTYRQAIFVAVYSNLLLLDHSSQVWWRWTSIFLTLAIWSVELMVSGDDDDSVTKKWKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J8A5</accession>
    <name>A0A2H3J8A5_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_165928</name>
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    <organism evidence="3 4">
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            <taxon>Phaeolaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467843">
        <property type="protein sequence ID" value="PCH34969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OMA" id="CTMAATI"/>
    <dbReference type="OrthoDB" id="3265734at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="179"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="255"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH34969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="301" mass="32199" checksum="C81A0F1B46A34BB8" modified="2018-01-31" version="1">MSDNAAVPTLFIVDDGDTRLKYQPPGAWDKSGCSYDSQILSGTSTAGSSVSFSFNGTLIAVYGILGKQQGSAEFTLDDEDSVHVSFPPQDSPVEQPFYWSDVLPLKEHTLNLTATKNGSYFCLSKMQYTGYAISTSSSASAIRTNVGTQASFYAAGSTSLPSTTSAVARSEQGVLNTGAIAGITFGCTMAATIVILTILYACGWKFCLKRDRRPSPERQMKIDLDAVDPPEAPLPYRGMDLLQKFLSQNGVRRYNNPQTSSSGPTSQGASSTMFTSVIIMTPPTSNASSGDRPARQTARRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J8R4</accession>
    <name>A0A2H3J8R4_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_159813</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH33064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J8R4"/>
    <dbReference type="STRING" id="742152.A0A2H3J8R4"/>
    <dbReference type="OrthoDB" id="5464at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="FAD-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH33064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="104" mass="11427" checksum="B6236126DCC178E7" modified="2018-01-31" version="1">MPGTGVLFGSHNWRSMDLILEVAYLGLGNATAEGAVPRKSRSAWRLDSCMRVAIRFEGCALWNLTEVMPYLSRRAIENKSVLGDGGAADERKRAGAEIWARLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J932</accession>
    <name>A0A2H3J932_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PAP2-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WOLCODRAFT_140327</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB467876">
        <property type="protein sequence ID" value="PCH36313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J932"/>
    <dbReference type="STRING" id="742152.A0A2H3J932"/>
    <dbReference type="OMA" id="LTVYQHE"/>
    <dbReference type="OrthoDB" id="302705at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042392">
        <property type="term" value="F:sphingosine-1-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03382">
        <property type="entry name" value="PAP2_dolichyldiphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039667">
        <property type="entry name" value="Dolichyldiphosphatase_PAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969:SF13">
        <property type="entry name" value="AT30094P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969">
        <property type="entry name" value="SPHINGOSINE-1-PHOSPHATE PHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="7">
        <location>
            <begin position="53"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PCH36313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="243" mass="27949" checksum="410A1822336E85D7" modified="2018-01-31" version="1">MAATNPRVSLDLTHVLYDETSTVSSVLALLTLSPILINPAYAVLAVQTRELFFMEMWAGQMLCEASNWVLKNLVRQQRPNDDLGDGYGFPSSHSQWMGYFSTFLICHILCRHRFVSTGWHAVDLLWKTLVLTGLVTWAGAVAFSRYYLGYHTAHQVIWGTVIGMLFGTFYYFTLEIIPDRYPQSGLGRFRTWVLSNPLSVWLRVRDGWAVWGDSGTEAQWLQWRAEWERKLKTRRSELGSKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J9M3</accession>
    <name>A0A2H3J9M3_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">WOLCODRAFT_29288</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">MD-104</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467943">
        <property type="protein sequence ID" value="PCH38962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J9M3"/>
    <dbReference type="STRING" id="742152.A0A2H3J9M3"/>
    <dbReference type="OMA" id="WPVDIFP"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
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            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
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                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
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                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
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                <person name="Kumar T.K.A."/>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PCH33774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="323" mass="34576" checksum="80068B00B49051E1" modified="2018-01-31" version="1">MPSDSPAPQSPPQSRSPSPSGTEVLTLRALVSTKDAGVIIGKGGKNVADLRDHTGVKAGVSKVVAGVHERVLTVSGSVEGVARAYALIVAQLVAANPSSPITNSPSPNTSIRLLISHNLMGSVIGRNGLKIKAIQDSSGARMVASKDMLPQSTERIVEVQGSSESIGRAIEEIGRCLLEDWERGQGTVLFYPGNGDDRTGRRSSNAGRRYNGDSASVRKTSPSPNSPTQQPTNLRTQNISIPSDMVGCIIGRNGTKITEIRRLSGSKISIAKEPHDETGERMFTIVGTPEANEKALFLLYNQLESEKERRVGRDQQQQDEMQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JAW3</accession>
    <name>A0A2H3JAW3_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">WOLCODRAFT_136420</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
            <location evidence="2">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NUF2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH38735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JAW3"/>
    <dbReference type="STRING" id="742152.A0A2H3JAW3"/>
    <dbReference type="OMA" id="YLKMEAH"/>
    <dbReference type="OrthoDB" id="8194677at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031262">
        <property type="term" value="C:Ndc80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051383">
        <property type="term" value="P:kinetochore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045132">
        <property type="term" value="P:meiotic chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.60">
        <property type="entry name" value="Ncd80 complex, Nuf2 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005549">
        <property type="entry name" value="Kinetochore_Nuf2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041112">
        <property type="entry name" value="Nuf2_DHR10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038275">
        <property type="entry name" value="Nuf2_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21650:SF2">
        <property type="entry name" value="KINETOCHORE PROTEIN NUF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21650">
        <property type="entry name" value="MEMBRALIN/KINETOCHORE PROTEIN NUF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03800">
        <property type="entry name" value="Nuf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18595">
        <property type="entry name" value="Nuf2_DHR10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="11" id="KW-0137">Centromere</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinetochore protein Nuf2 N-terminal" evidence="13">
        <location>
            <begin position="5"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Nuf2 DHR10-like" evidence="14">
        <location>
            <begin position="254"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="176"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="281"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF18595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PCH38735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="443" mass="51418" checksum="8CB2084ACF9042F0" modified="2018-01-31" version="1">MSGQFWFPSMSVPEIVDAFTGWGYMVSHEEVARPTPDFVLGIYSACLKQVTGITVESIQGPVEAALARVSNPDIYRQALTHHFLLYHLQRFATAAKFHGFCAKDLNNPEPERTRAIFSAFINFVKFSEQCETFITGLRERSAGMVEERDSVAQQLTDAHRKIAYIKVKREEDEPKCEALRHENTAMTEQLVKYKETQLVFLRDREALKQEIEAVLQSKEGVNRETLLITEQIGRTRSRVVQSPDRIRRNIVTMSATAAEDKRTLATNEAKIRDLQTKIAALLNIEKDVRSCVEQLQTYEKETQALDAAQKELADIRDHLDLKKSERTELLLKRERVFKQLSNAQEKLDRAQRHAEDKRLASQQALERLQREYEEMAVERRENDKQVEELRREADEVERKMAEHMKQSQAELDELLTEYWRLRHETEVYMETLAEKLGMQVTST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JB27</accession>
    <name>A0A2H3JB27_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">L-fuconate dehydratase</fullName>
            <ecNumber evidence="3">4.2.1.68</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WOLCODRAFT_141280</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-fuconate = 2-dehydro-3-deoxy-L-fuconate + H2O</text>
            <dbReference type="Rhea" id="RHEA:22772"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:21291"/>
            <dbReference type="ChEBI" id="CHEBI:37448"/>
            <dbReference type="EC" id="4.2.1.68"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="4.2.1.68" evidence="3"/>
    <dbReference type="EMBL" id="KB467998">
        <property type="protein sequence ID" value="PCH39452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JB27"/>
    <dbReference type="STRING" id="742152.A0A2H3JB27"/>
    <dbReference type="OMA" id="SGAIDVC"/>
    <dbReference type="OrthoDB" id="14161at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050023">
        <property type="term" value="F:L-fuconate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009063">
        <property type="term" value="P:amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03324">
        <property type="entry name" value="rTSbeta_L-fuconate_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="entry name" value="Enolase-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="entry name" value="Enolase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034610">
        <property type="entry name" value="L-fuconate_dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018110">
        <property type="entry name" value="Mandel_Rmase/mucon_lact_enz_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013341">
        <property type="entry name" value="Mandelate_racemase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046945">
        <property type="entry name" value="RHMD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13794">
        <property type="entry name" value="ENOLASE SUPERFAMILY, MANDELATE RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13794:SF58">
        <property type="entry name" value="MITOCHONDRIAL ENOLASE SUPERFAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02746">
        <property type="entry name" value="MR_MLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00001">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="Enolase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="Enolase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00909">
        <property type="entry name" value="MR_MLE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mandelate racemase/muconate lactonizing enzyme C-terminal" evidence="8">
        <location>
            <begin position="198"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PCH39452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="469" mass="51945" checksum="7E410E6234E6FF65" modified="2018-01-31" version="1">MSVKITGYETHDVRFPTSLTGDGTDAMNTDCDYSSAYVTLFTSGDLVGHGMTFTIGRGNDIVCAAIRELAQRLVGKDTEELFANMGKTWEYLCADPQLRWIGPEKGVIHIALGAVDNALWDMYARSRNKPLWKLVVDFTPEELVNATAFRYITDALTREEALEMLKAKASTKAEREARVRELGYPAYVTSAGWLGYTDEKVARLTREAVEAGFNHFKMKVGADRDSDLRRGKIIRSIIDDPQYLSAGATPRDPNGPDLRGKNAGPTGSVLMIDANQVWDVPQAIEYVKSLEEIKPWFIEEPTAPDDILGHAAIRKALKPHGIGVATGEHAHNRMVFKQLLQSEAIDVCQIDSCRLAGVSEVLSVLLMAAKFGVTVCPHAGGVGLCEYVIHLSLIDYIAVSGSMERNVLEFVDHLHEHFLYPCSINKNGRYNVPNNDKEGYSIEMHKSSIAEYEWPHGSYWVSSAKSKGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JB60</accession>
    <name>A0A2H3JB60_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WOLCODRAFT_86616</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat UTP18 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH33187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JB60"/>
    <dbReference type="STRING" id="742152.A0A2H3JB60"/>
    <dbReference type="OMA" id="DLNRATY"/>
    <dbReference type="OrthoDB" id="1935146at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045161">
        <property type="entry name" value="Utp18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18359:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 18 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18359">
        <property type="entry name" value="WD-REPEAT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="31"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="214"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="121"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="137"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="214"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PCH33187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="494" mass="54399" checksum="DD0683F9A97CB7C0" modified="2018-01-31" version="1">MVKHPHKKQKTVKGFGYTSEAVQPLGAIISATDDAAKDDEERRLESSLFGTPYEPSGQLGIELPSVSDEEDEDNAGAKELQNLLDSDLFFIDDGVGQPPQSDQPTSDVDFEEGNFHTARDPEDEEEPDKMDVEETSDGQNKGMSQTPAPFNRSRHRKSAWVDPDDPTLQVSLSTDKRRRKLRDALSEDVVGGREYERRLRRQFEKINPTPSWAVNARTKLQSKQVKRRRPSSLSASESDEDAPVSELLSDTRGILQRSRKTNVLSQGTIAIERLRDANLSAKAEGAVKTIQFHPSPQVPVLLTASADRRLRLFNIDGHTNPHLQTVHIPDLPLTNALFHPSGASVLLTGPRPYYYIQDLQSGATIRSPRGLWGTTFTNANTAAQDGSLEMCAFDPTGSVLAVAGRRGHIHLVDWRGGQGQVVGSVKMNVGVKSLWWAGGGRSELMTLGEDAEVYMWDVGGRKCVRRWNDDGGYGSRILGGDRAGQYLAIGCAFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JBR8</accession>
    <name>A0A2H3JBR8_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WOLCODRAFT_85060</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB467954">
        <property type="protein sequence ID" value="PCH39025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JBR8"/>
    <dbReference type="STRING" id="742152.A0A2H3JBR8"/>
    <dbReference type="OMA" id="YPTIAVN"/>
    <dbReference type="OrthoDB" id="2962993at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000034">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF46">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="273"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="301"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="329"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="353"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="388"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="421"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="36"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PCH39025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="489" mass="53674" checksum="6AC84B6A9FDC1522" modified="2018-01-31" version="1">MSLSEEKSDSVASTELPYQAHLVDRDHVLRKLDWHLLPFVSLLYLLAFLDRTNIGNAKIAGLTTDLNLTGLQFNLCSAMFFIPYCLLDIPSNVAIKYFKPSRWIPSIMFCWGIIMLSMAFVKNFSGLMAVRILLGAAESGLFPGVSFYLCLWYPRDAQARRLGIFTAASSMAGSAFGGILAYAIERMNGIGGLAGWSWIFLLEGLVTVVVAISAYYYMEDYPESASFLTNEEKEWLVQTIRADIVASSKALKRKFLWQALRDPHSYILASMDLFVVIPLFSLALFLPTIIVGLGYSSLHAQLLTIPPNICGSIVTILIGALSDRMRVRGPFVLAGACVTLTGYVLLYATTEPIVGYVGTLIAASGIYQASTCVLAWTSANAGGDIKRGTMIAIVSGIGNSGAIASSFIYRSADSPRYHPGHITNIACCCILATLSIIGMLEYMRLNRLKRAYCLKEGIDASRYEEFSEMGDKSPLYGYVSSLWKPGRSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JBU1</accession>
    <name>A0A2H3JBU1_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Iron-sulfur clusters transporter ATM1, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Iron-sulfur clusters transporter atm1, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">WOLCODRAFT_134745</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">MD-104</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="742152.A0A2H3JBU1"/>
    <dbReference type="OMA" id="VFHIIPI"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140466">
        <property type="term" value="P:iron-sulfur cluster export from the mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18582">
        <property type="entry name" value="ABC_6TM_ATM1_ABCB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03253">
        <property type="entry name" value="ABCC_ATM1_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000004">
        <property type="entry name" value="ATP-binding cassette sub-family B member 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000186">
        <property type="entry name" value="ATP-binding cassette sub-family B member 7, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221:SF402">
        <property type="entry name" value="IRON-SULFUR CLUSTERS TRANSPORTER ABCB7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="128"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="233"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="323"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="16">
        <location>
            <begin position="88"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="15">
        <location>
            <begin position="410"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00039906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00040792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PCH39371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="665" mass="74594" checksum="7849BBE9350F40E8" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JC32</accession>
    <name>A0A2H3JC32_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_159542</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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        <property type="entry name" value="RCC1/BLIP-II"/>
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        <property type="entry name" value="Reg_chr_condens"/>
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        <property type="entry name" value="F-BOX PROTEIN POF9"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="F-box domain"/>
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        <property type="entry name" value="RCC1_3"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="132"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH35768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="565" mass="63092" checksum="06D527806D38D56E" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JDP5</accession>
    <name>A0A2H3JDP5_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">poly(A)-specific ribonuclease</fullName>
            <ecNumber evidence="5">3.1.13.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">WOLCODRAFT_116469</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">MD-104</strain>
        </source>
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        <reaction evidence="1">
            <text>Exonucleolytic cleavage of poly(A) to 5'-AMP.</text>
            <dbReference type="EC" id="3.1.13.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
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        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
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    <comment type="similarity">
        <text evidence="4">Belongs to the CAF1 family.</text>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CNOT7/CNOT8/Pop2"/>
    </dbReference>
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        <property type="entry name" value="RNase_CAF1"/>
    </dbReference>
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        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
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        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10797">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04857">
        <property type="entry name" value="CAF1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0678">Repressor</keyword>
    <keyword evidence="13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="15" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="16" id="KW-0804">Transcription</keyword>
    <keyword evidence="14" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="12" id="KW-0810">Translation regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="274"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="274"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001663"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PCH40001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="344" mass="38109" checksum="4B261601689D7F2B" modified="2018-01-31" version="1">MSRIREVWAPNLEQEMNNIRDLIDKYPYVAMDTEFPGVVARPIGSFKTSSDYHYQTMRCNVDLLKIIQVGLTLADEEGNYPQDVSTWQFNFHFSEGEDMYAPESIDLLRESGIDLRRHEEMGIELNDFAELMITSGLVLAPETKWISFHSGYDFGYFIKLLTAESLPTTEEAFFEVLRTWFPTIYDIKFVMRACKVLKGGLQDVADDLGVMRIGPSHQAGSDSLLTASTFFKMRELYFNDHIDDAEYNHKLYGLGQTFVNGIAEPVRGSAATIAEREDRGSARETHNQTPGPAQGHSVAAVALGLGGSMPTPALSGALQPQAPYGPMGANGPFMRTAIGVGGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JDR2</accession>
    <name>A0A2H3JDR2_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_136811</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OMA" id="AHPYANE"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="242"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH40346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="422" mass="45935" checksum="7629DAF298225A52" modified="2018-01-31" version="1">MCASTPLAIRTNHSRNETSRDAHFQYKLQSAQSPLRAYKPSLPIAIPRRKTARPPPCSPLRHQSPPELVFNLDFSVSPCSFHGSGEILSQKDEWIPAFLQQRGRANLLLAHQCYQQKARYMDVARQTRSPSVKCKERPPLAYAAPWDVKPAVQAGQECAFSDRTAGEHEQENVSAGVHSRHASPSSSEASFAVFTTPSGDALEPEPLDYACKHGNDAGPDENTDLRLTSAFQRSIASSVVSQSALSSSLRSRSESPYSFSDRPASPAVRHPFTPVSQSPPAPRVFQVYPARRPLPLPTAFPTGPTAMKGRAHLLRSAAAPVVSLKVAQAERVETPPRGRSPAPRGCRSPSGVRGPTVVGFGRVCGRGIARVPSIVLSNEELERSLEHGQEKIEEPVEKERGRPRGRTRARGIAVVRAAPGHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JEC5</accession>
    <name>A0A2H3JEC5_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Terpenoid synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_117435</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the trichodiene synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468053">
        <property type="protein sequence ID" value="PCH40556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JEC5"/>
    <dbReference type="STRING" id="742152.A0A2H3JEC5"/>
    <dbReference type="OMA" id="IKGTMEF"/>
    <dbReference type="OrthoDB" id="2998174at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016838">
        <property type="term" value="F:carbon-oxygen lyase activity, acting on phosphates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024652">
        <property type="entry name" value="Trichodiene_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06330">
        <property type="entry name" value="TRI5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01021">
        <property type="entry name" value="Trichodiene_Synthase_Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH40556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="308" mass="35079" checksum="83DCAE4632EBDCB3" modified="2018-01-31" version="1">MAYSGSVIDVSRHAVCDLLERLKLDVPTYQRDYKLESRVKDVLRSWGVEKQLQPYLPPALILTTTCYHHITDIETKVHIALFSTLVIALDDPSILSTQAPDEFHRRLCSGAIQRELDILGRLTNNLGEMWGHYPPFAASSIFTSALQFVNGCLLEQCAQKGAILSSDALPFITYRRNMSGLAEAFAYFIWPKDKFPDVEVYMQAIPDICWYQNHVNDILSFYKEELAGETGNYMSDRAAASGRTTLETLSEVIDETVVIMQRIRNILGEGEARDAWESFARGWIAFHTSSPRYRLKELIDCEYIIINH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JEL6</accession>
    <name>A0A2H3JEL6_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_62365</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH34427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JEL6"/>
    <dbReference type="OMA" id="PTHIMAC"/>
    <dbReference type="OrthoDB" id="3257768at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040521">
        <property type="entry name" value="KDZ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18758">
        <property type="entry name" value="KDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH34427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="209" mass="23328" checksum="1988491E8360EE1E" modified="2018-01-31" version="1">MGFGRYGGKVSGTVGLSCARHMFVLPGGGVDLQKGERFANVDFAMLSGLQPWMNLRTHVSGYDINCQYGIHFDKRMTEIVRRISQFPSMSFKYFPNIVRAIGKFHLPAHKALCRWKFSYHWLPGVGMTDGEAPERIWATLNALGARTREMTAGHRHDVINDHHSDMNVRQVHGIGSYLSGMGISGRLNIIAAKDLAKKHSQAIEQETAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JEU2</accession>
    <name>A0A2H3JEU2_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_139810</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467843">
        <property type="protein sequence ID" value="PCH35224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JEU2"/>
    <dbReference type="OMA" id="ANECDIA"/>
    <dbReference type="OrthoDB" id="2657661at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="465"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="518"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="555"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH35224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="621" mass="70552" checksum="1500E4AD26CAD357" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JFP4</accession>
    <name>A0A2H3JFP4_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_143346</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JFP4"/>
    <dbReference type="STRING" id="742152.A0A2H3JFP4"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="DUF6534"/>
    </dbReference>
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        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="2">
        <location>
            <begin position="59"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH41016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="192" mass="21785" checksum="40336EC03158C04B" modified="2018-01-31" version="1">MQTRYSVIYDHSSRDRSYLMAHTSGDMASAEESYYTQTSTSVIYFYGKWPTILQTVFASVADICITVFMCCYFMKNAREPSLEQTKSLLRTLTVYTINRGLLTTYVSSVLSGGVCTEDALRVLQILQAVTFIVYHEGVFYWLSFHFTGSKDESDVVYVNSLLALLNARRRLRRVSQPDSSLNLAQINVTSPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JFT5</accession>
    <name>A0A2H3JFT5_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_24461</name>
    </gene>
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        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
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                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH41062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JFT5"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="109"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH41062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="155" mass="17097" checksum="B3B478CB9D6528E3" modified="2018-01-31" version="1">MVCLLFSTVRRTTRPRQSAGDASNTHHQLVPVTAVDANRVSGDEGVEWRDAELIDCRAAGDRYTEELYRDMDMYSLGTDDLVDQEVDVYDNDYDDGGVVQRAEPDSERASYATSSDASSNSGFTVLEIVDIKLECILARPSVPLSAEELLRFPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JFU0</accession>
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            <fullName evidence="1">Uncharacterized protein</fullName>
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        <name evidence="1" type="ORF">WOLCODRAFT_24455</name>
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        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH41056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JFU0"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH41056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="157" mass="17578" checksum="62A5B67D313B64B7" modified="2018-01-31" version="1">MVSLFFSTVRRTTRARQSAGDASNTHHQLVPVTAVDADHVSRDEGLEWRDAELIDCRAAGDRDPEQLYRDVDMYSLGTDELVIDQEIDVYDSGGVVQRAEPDSERASYAIGRSASFNSGFTLLEVIDIKLEWILARPTVPLLAEELLRFPAGYRDFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JFX1</accession>
    <name>A0A2H3JFX1_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="11">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">WOLCODRAFT_64493</name>
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    <organism evidence="14 15">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16 17">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="11"/>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH38733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JFX1"/>
    <dbReference type="STRING" id="742152.A0A2H3JFX1"/>
    <dbReference type="OMA" id="HHDIPKS"/>
    <dbReference type="OrthoDB" id="10261556at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
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        <property type="entry name" value="DEXHc_RecQ"/>
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        <property type="entry name" value="ATP-dependent DNA helicase"/>
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    </dbReference>
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        <property type="entry name" value="ATP-dependent DNA helicase RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032284">
        <property type="entry name" value="RecQ_Zn-bd"/>
    </dbReference>
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        <property type="entry name" value="RQC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00614">
        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF153">
        <property type="entry name" value="RECQ-LIKE DNA HELICASE BLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16124">
        <property type="entry name" value="RecQ_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09382">
        <property type="entry name" value="RQC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00956">
        <property type="entry name" value="RQC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 11 14" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="30"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="236"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PCH38733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="530" mass="60371" checksum="71EA5361D2553CE0" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JG51</accession>
    <name>A0A2H3JG51_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GTP cyclohydrolase II</fullName>
            <ecNumber evidence="3">3.5.4.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WOLCODRAFT_137053</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>GTP + 4 H2O = 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + formate + 2 phosphate + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:23704"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58614"/>
            <dbReference type="EC" id="3.5.4.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; riboflavin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GTP cyclohydrolase II family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.25" evidence="3"/>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH40881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JG51"/>
    <dbReference type="STRING" id="742152.A0A2H3JG51"/>
    <dbReference type="OMA" id="DFFPGVM"/>
    <dbReference type="OrthoDB" id="5569761at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003935">
        <property type="term" value="F:GTP cyclohydrolase II activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00641">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10990">
        <property type="entry name" value="GTP cyclohydrolase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032677">
        <property type="entry name" value="GTP_cyclohydro_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000926">
        <property type="entry name" value="RibA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036144">
        <property type="entry name" value="RibA-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001591">
        <property type="entry name" value="PRK00393.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21327">
        <property type="entry name" value="GTP CYCLOHYDROLASE II-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21327:SF29">
        <property type="entry name" value="GTP CYCLOHYDROLASE-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00925">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142695">
        <property type="entry name" value="RibA-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0686">Riboflavin biosynthesis</keyword>
    <feature type="domain" description="GTP cyclohydrolase II" evidence="10">
        <location>
            <begin position="270"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="95"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="154"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PCH40881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="481" mass="52830" checksum="8258FF1BA6601883" modified="2018-01-31" version="1">MDLQKGIEQGLSDLALLDMLTAPDLPVRKHRLKRRDSDLDPLLLAAAAAYGPHVTRNHYAHDFFPAVGDPRAEGAYDWTRFQGEVKQGRRRYKYVSRQAPRSERLKREGKENDAVREATDPLRCADNLPLPRPQTAHSPAEIPPSTTPAGLKGSPPTTASAANAATSPVPPALEVKCMARTRVPTPHGPVFLHLYHNNRDNKEHLAIVVDSAQLRNDIPHLAPPIRSRTLDAKWSDTETETDRITRGAYVGRLSPSSQIPSAPSEQPTITLDTIPSPLVRIHSECFTGETIGSMRCDCGEQLDEAIRQISQPISTLTGSIPGRGAVVYLRQEGRGIGLLEKIRAYNLQDLGHDTVAANLLLGHKADERAYDVAAAILRDLGLGVEAGEGVRLLTNNPDKVHALQEEGIRIVERVPMVPRSWQRRQHVHMDAVANVKVGAEEEHAGLTMIGGGEVHGEDLDRYLRTKVLKMGHMLSLTDLDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JG60</accession>
    <name>A0A2H3JG60_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_167642</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467943">
        <property type="protein sequence ID" value="PCH38823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JG60"/>
    <dbReference type="STRING" id="742152.A0A2H3JG60"/>
    <dbReference type="OrthoDB" id="3057032at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="474"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="567"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="567"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="599"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH38823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="691" mass="72712" checksum="77295637D6A107F0" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JGR7</accession>
    <name>A0A2H3JGR7_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">acetylornithine transaminase</fullName>
            <ecNumber evidence="5">2.6.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WOLCODRAFT_137356</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD-104</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 4/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.11" evidence="5"/>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH41372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="742152.A0A2H3JGR7"/>
    <dbReference type="OMA" id="MVPGFKY"/>
    <dbReference type="OrthoDB" id="10260828at2759"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00109"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Acetylornithine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004636">
        <property type="entry name" value="AcOrn/SuccOrn_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050103">
        <property type="entry name" value="Class-III_PLP-dep_AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00707">
        <property type="entry name" value="argD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986:SF79">
        <property type="entry name" value="ACETYLORNITHINE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986">
        <property type="entry name" value="AMINOTRANSFERASE CLASS III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 11" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="9 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00005024"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012919"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PCH41372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="496" mass="52924" checksum="AF58A461FF23765E" modified="2018-01-31" version="1">MLLVARCAGQTLAWQARRSAGVRLASTIPESAPRPAPKLPTAPCTRYAAVSHPEDPSAVSAEVKALLDRSDAYILPVYARPPFVLSHGKGAYVWDTQGRRYLDFSAGIAVNALGHADQGVANVLASQAATLMHTSNAFHHKWSGELAKLLVTLTQREGGLGWEAGSRHPPAGVTSGAKVFFSNSGTEANEGALKIARKVGKARWAAKTSKAWDDPACDKYEIVCFGSAFHGRSMGALSVTTNPKYQKPFAPLLPGVKVGKLNVTEELQTLVDEKTCAVIVEPIQGEGGIHAADVAWLQALRERCDEVGAVLIFDEIQCGLYRTGTLWAHSMLPVDAHPDIITMAKPLANGFPIGAVLMRDAVAETMTAGTHGTTFGGSPLACALGHHVLSRVSERAFIANVAETSAYLHARLSQTTQWFRDIIEPSVRGRGLILGLGFKDQSHPAKVVSMARERGVLILTAGSDAVRLVPSLNVGQTEVNTTVDVIESCLHVLQTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JGY4</accession>
    <name>A0A2H3JGY4_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_156696</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467865">
        <property type="protein sequence ID" value="PCH35974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JGY4"/>
    <dbReference type="OMA" id="IFREGHA"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH35974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="419" mass="47943" checksum="DB56A72AE2776361" modified="2018-01-31" version="1">MTFIYIPLCKVNPWTQFLIATSIERSIERGIDILVTPGNRELSAELEAQCCTVVFKVLKQFIGSIRNLSVVVHNMTTIAEILPYLAGNAERLQSLNLVVLCSDPDAAFPVLQPLQLMIKAPQIRRVEVGSVPITVSQSDVSSAQELAIRSRVSCIDRSCCGILHFAADFYRLRRLELHDMSYDFKLDFMSSYFKLNTAQGIRRTIRFEFLEELALGCVDADFIEEVLINIEAPNLKKVIITPNYSQHFSAQNELRDKFPRLECVVINNASPQLLRCIYCLLEPKDIYLRHLESIDDILLDLSSGSRIPCCKTAKKMQIWGTNVSAEKLHILVEIRKSASCALRELKVHTGIDNCLWGDRSWFQENVETFSWETVLDLASLEHNRRIQLSCERIKDEQKDEVLSRPLTVIHRENSVFWSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JH01</accession>
    <name>A0A2H3JH01_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_151490</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH41446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JH01"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH41446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="216" mass="23826" checksum="E6A74972204BDE04" modified="2018-01-31" version="1">MHMRQDPCAPFPHDQVDAAGAQITFAHSQISARPKTEQRVCRDAPPPRLIFSRPRHTAPPGGYLVQLHAVYQACRVHFDHLRQQAAAPASHARTRPLTGPACLPRSRWASAPRPQMSTALLALHARFSPAIAIAAVWLATRGVACVGIAYYYHPLSRTLDLAATYEVAPDAAARSKPAPARSTSRRAGADEHPVFRFTRRDAAQADYLRWLARSNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JH54</accession>
    <name>A0A2H3JH54_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_163167</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH41520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="742152.A0A2H3JH54"/>
    <dbReference type="OMA" id="HICHITA"/>
    <dbReference type="OrthoDB" id="2343366at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22796">
        <property type="entry name" value="URG4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22796:SF1">
        <property type="entry name" value="VWFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH41520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1561" mass="173982" checksum="C0593C44A28FFE5A" modified="2018-01-31" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JHW7</accession>
    <name>A0A2H3JHW7_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="3">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WOLCODRAFT_149286</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA polymerase delta/II small subunit family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="3"/>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH38349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JHW7"/>
    <dbReference type="STRING" id="742152.A0A2H3JHW7"/>
    <dbReference type="OMA" id="GETDEWI"/>
    <dbReference type="OrthoDB" id="3763at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043625">
        <property type="term" value="C:delta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006273">
        <property type="term" value="P:lagging strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.430:FF:000002">
        <property type="entry name" value="DNA polymerase delta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040663">
        <property type="entry name" value="DNA_pol_D_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024826">
        <property type="entry name" value="DNA_pol_delta/II_ssu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10416">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10416:SF0">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18018">
        <property type="entry name" value="DNA_pol_D_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA polymerase delta subunit OB-fold" evidence="11">
        <location>
            <begin position="40"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="281"/>
            <end position="290"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH38689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="57" mass="6684" checksum="EBFFC1D1E96AC98E" modified="2018-01-31" version="1" fragment="single">LIPIPMFLSHYVFSLTFFKGWVIICVIWLFIAAFITSILPLWESRRAMTQIARGVIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JJF3</accession>
    <name>A0A2H3JJF3_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Histone acetyltransferase</fullName>
            <ecNumber evidence="3 12">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">WOLCODRAFT_72255</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the MYST (SAS/MOZ) family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3 12"/>
    <dbReference type="EMBL" id="KB468124">
        <property type="protein sequence ID" value="PCH42316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JJF3"/>
    <dbReference type="STRING" id="742152.A0A2H3JJF3"/>
    <dbReference type="OMA" id="EGRLWIC"/>
    <dbReference type="OrthoDB" id="787137at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990467">
        <property type="term" value="C:NuA3a histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.60:FF:000001">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000001">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.60">
        <property type="entry name" value="N-acetyl transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002717">
        <property type="entry name" value="HAT_MYST-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050603">
        <property type="entry name" value="MYST_HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040706">
        <property type="entry name" value="Zf-MYST"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615:SF161">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE KAT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01853">
        <property type="entry name" value="MOZ_SAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17772">
        <property type="entry name" value="zf-MYST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51726">
        <property type="entry name" value="MYST_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYST-type HAT" evidence="13">
        <location>
            <begin position="15"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="11">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR602717-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PCH42316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="238" mass="27614" checksum="5DD82A484EBF03A6" modified="2018-01-31" version="1" fragment="single">SESPVTPGPQIQLPLKGPRIRRIRFGEYDIETWYDAPFPEEYSNIPDGRLWLCEFCLKYMKSRFVSGRHQLKCKMRHPPGDEIYRDGSVSIFEVDGRKNKIYCQNLCLLSKMFLDHKSLFYDVEPFLFYVIAEFDDVGARFVGYFSKEKRSPKDYNVSCIMTLPVRQRQGWGQLLIDFSYLLSKKEQRAGSPEKPLSPLGALGYKSYWTFALMRYFQTAPPEPSLEGQSIDVSALTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JJM3</accession>
    <name>A0A2H3JJM3_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Alpha-1,3-glucosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WOLCODRAFT_67502</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD-104</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2 10">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the ALG6/ALG8 glucosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="EMBL" id="KB468053">
        <property type="protein sequence ID" value="PCH40063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JJM3"/>
    <dbReference type="STRING" id="742152.A0A2H3JJM3"/>
    <dbReference type="OMA" id="FQVPPMH"/>
    <dbReference type="OrthoDB" id="5589195at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042281">
        <property type="term" value="F:dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004856">
        <property type="entry name" value="Glyco_trans_ALG6/ALG8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12413">
        <property type="entry name" value="DOLICHYL GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12413:SF1">
        <property type="entry name" value="DOLICHYL PYROPHOSPHATE MAN9GLCNAC2 ALPHA-1,3-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03155">
        <property type="entry name" value="Alg6_Alg8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="5 10 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013944241" description="Alpha-1,3-glucosyltransferase" evidence="12">
        <location>
            <begin position="29"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="300"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="345"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="369"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="445"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="476"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="505"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="522"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="560"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PCH40063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="578" mass="64159" checksum="D57B5662DF3D156F" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JJP0</accession>
    <name>A0A2H3JJP0_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribonuclease</fullName>
            <ecNumber evidence="9">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WOLCODRAFT_132367</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 9">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase HII family. Eukaryotic subfamily.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OMA" id="REECRFF"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032299">
        <property type="term" value="C:ribonuclease H2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07181">
        <property type="entry name" value="RNase_HII_eukaryota_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.460:FF:000001">
        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000016">
        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.460">
        <property type="entry name" value="Ribonuclease hii. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001352">
        <property type="entry name" value="RNase_HII/HIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024567">
        <property type="entry name" value="RNase_HII/HIII_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023160">
        <property type="entry name" value="RNase_HII_hlx-loop-hlx_cap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954:SF7">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01351">
        <property type="entry name" value="RNase_HII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51975">
        <property type="entry name" value="RNASE_H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8 9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-2" evidence="11">
        <location>
            <begin position="47"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PCH42402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="327" mass="34978" checksum="8B3476EE6F563F65" modified="2018-01-31" version="1">MSVKTSEPEAIAGPSTGNPGIPSIADPSSPLTASYTYHSPIPTAPGPYILGVDEAGRGPVLGPLVYGVAYCPAAYQDDLEQLGFADSKTLTASTRSTLLETLCSDPKNLAWSVRVLSPQAISSGMLKRPPINLNRQSEQATILLIREVLEQGIQLSEVYVDALGPTKTYEAYLSSQFPDINFTVTAKADSKFKIVGAASVAAKVTRDAWVEGWIFEEHSSSEGAGDPQAMTVKAKALWKEELGSGYPSDPKTQAWIKDSLEPTFGFPSLARFSWTTIKLAMEKHGYAVQWIDDGQASLVKAFESGVGLDKGRSAVAKDLCLKSVSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JJQ8</accession>
    <name>A0A2H3JJQ8_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_73029</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468124">
        <property type="protein sequence ID" value="PCH42426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JJQ8"/>
    <dbReference type="STRING" id="742152.A0A2H3JJQ8"/>
    <dbReference type="OMA" id="VTRGMSM"/>
    <dbReference type="OrthoDB" id="5550090at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH42426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="279" mass="30136" checksum="C91A5DFD85FF553E" modified="2018-01-31" version="1">MSPTTRPVKNIKVKVPRHNSQRLGPAVTAQVETFAREDRIRVDVRQTAYDPSSALAQAIESASDWNSLLLNARAERGPQWDIGTQQFLVEEYSDLYYDPTPLLAYQKEGQSSTDNDETSKANAQTDKTPQDFPSTPKPPSHIQMHRTLSQSTPVHTPHHAQNPAQFFGGSAPPGMSSPRHPFTSPAQAGQGMGFNNMGMSPIPAPQFYGAGADSPMRMGNPAMAQMGGMGMNMPNMGMGMGMGMHADDMGMGMGMNSPDPRRRITRVMSGDGGFGGMHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JKA6</accession>
    <name>A0A2H3JKA6_WOLCO</name>
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        <recommendedName>
            <fullName evidence="5">TOM13-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_137826</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468124">
        <property type="protein sequence ID" value="PCH42291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JKA6"/>
    <dbReference type="STRING" id="742152.A0A2H3JKA6"/>
    <dbReference type="OMA" id="AHVAEWR"/>
    <dbReference type="OrthoDB" id="5529571at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070096">
        <property type="term" value="P:mitochondrial outer membrane translocase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013262">
        <property type="entry name" value="OMP_MIM1/TOM13_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28241">
        <property type="entry name" value="MITOCHONDRIAL IMPORT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28241:SF1">
        <property type="entry name" value="MITOCHONDRIAL IMPORT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08219">
        <property type="entry name" value="TOM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="156"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="76"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="121"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="207"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="322"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH42291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="342" mass="36485" checksum="CA671AAEFB02E709" modified="2018-01-31" version="1">MAEQLNAEEERLLQSALQTAFSPAPLPQESALPEEPALAPEAEPAPVAPAPDPAAELAPENESAEELWKAEYDAHVEEWRRASAEQRERAEQERARWEEVRAREQALGIAKESLTDDLGAHLRADQERGESGWESVGGSGTGSIVLESVVSVDAGAQGAPAAEPSVADARDLVSGERQGRRTAEELEKILPGSSHAHEKWEDIPEQGLSGSDSLASSYPSLSFPSSSPSGVHPHQPPPHARSHAHPPSARQADRPPAPSTTLAVFDTTLSPRTRVLALLSALAVNVALPFVNGVMLGFGEIFAKEVLVGWFGWGRRAGAGVSRERERTKGAGRREAGLGLHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JKE4</accession>
    <name>A0A2H3JKE4_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Complex I intermediate-associated protein CIA30</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WOLCODRAFT_138012</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CIA30 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468124">
        <property type="protein sequence ID" value="PCH42666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JKE4"/>
    <dbReference type="STRING" id="742152.A0A2H3JKE4"/>
    <dbReference type="OMA" id="WIKAVAQ"/>
    <dbReference type="OrthoDB" id="42561at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010257">
        <property type="term" value="P:NADH dehydrogenase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013857">
        <property type="entry name" value="NADH-UbQ_OxRdtase-assoc_prot30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039131">
        <property type="entry name" value="NDUFAF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13194">
        <property type="entry name" value="COMPLEX I INTERMEDIATE-ASSOCIATED PROTEIN 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13194:SF18">
        <property type="entry name" value="COMPLEX I INTERMEDIATE-ASSOCIATED PROTEIN 30, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08547">
        <property type="entry name" value="CIA30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:ubiquinone oxidoreductase intermediate-associated protein 30" evidence="5">
        <location>
            <begin position="40"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PCH42666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="268" mass="30762" checksum="4F18157D95ECE67E" modified="2018-01-31" version="1">MSRFAQTLMRTTQHLRGQTAKALRMQGADEPFRAPQTLLTFSSREDLQNYAIGCDTDIGGLSTAHLDLVEPTEKDNEQTRPYVKFWGEMRLGARKELEGKIRSGYAGFRSKRRRMLIGEITDDVSMHRFLALRLRAAGHPRTRNSYYVNIQTDGPVETDLWQHRLYFRREDGGWEDIYIPFDEFVLTNTGEVSQQQMTMFRERLRTIGISILGGNSGVEGPYELGIDSIRAVNEEDVPSDHARRERTVRRDAVGETRGMSIKCRAEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JKF0</accession>
    <name>A0A2H3JKF0_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WOLCODRAFT_28615</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
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                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
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                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
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                <person name="Martin R."/>
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                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
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                <person name="Ohm R.A."/>
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    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH42145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="268" mass="28411" checksum="6A5699C09FB5C7ED" modified="2018-01-31" version="1">MPVTTPVTTVAAPALARLGSDAFMVVSCTLLPSLRSPRQSPVAVADALPSSLSTRQTSSSPCSAAHARSQALACRRAHAAKDERVVRALSRSTPFLASTVSCKPPYSCTPLTSPLAGTRAEVRDANLELKSSIQPSAIGCSISPGLRSIHTFKDSAHRTFVARLGIVKNANSIFWWSGVYEKVDSSAAPAHGAAADGASDGLKWTPYTIYGGEPLDVVAIVSRLDGEMPVTTKLLASCSGVMNGIVDSVFNEIKKDHRRLFWTEGCWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JKV1</accession>
    <name>A0A2H3JKV1_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_29563</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467998">
        <property type="protein sequence ID" value="PCH39419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JKV1"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH39419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="107" mass="11704" checksum="D52C03DE503E3780" modified="2018-01-31" version="1">MPNGPYVLTRNQSSRTITVVDSSRQVPCSFSAHHGSDVVHVLNFTGPMTPVQIHSLFLCETAQEESSVVSFPVLWTPRAEHEESAVRSFPRLLGSSSLPSIIHGYGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JL95</accession>
    <name>A0A2H3JL95_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNase I-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_83334</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467898">
        <property type="protein sequence ID" value="PCH36777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JL95"/>
    <dbReference type="STRING" id="742152.A0A2H3JL95"/>
    <dbReference type="OMA" id="VREDAWC"/>
    <dbReference type="OrthoDB" id="7862313at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046985">
        <property type="entry name" value="IP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048869">
        <property type="entry name" value="OCRL-1_2_ASH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200:SF300">
        <property type="entry name" value="TYPE II INOSITOL 1,4,5-TRISPHOSPHATE 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21310">
        <property type="entry name" value="OCRL-like_ASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inositol polyphosphate-related phosphatase" evidence="1">
        <location>
            <begin position="249"/>
            <end position="636"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH36777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="868" mass="96116" checksum="DFCF94B594736AE1" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JLE3</accession>
    <name>A0A2H3JLE3_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">DNA-directed RNA polymerase subunit beta</fullName>
            <ecNumber evidence="15">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">WOLCODRAFT_18098</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol III is composed of mobile elements and RPC2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 15">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="15"/>
    <dbReference type="EMBL" id="KB468135">
        <property type="protein sequence ID" value="PCH43022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JLE3"/>
    <dbReference type="STRING" id="742152.A0A2H3JLE3"/>
    <dbReference type="OMA" id="LAYCSWC"/>
    <dbReference type="OrthoDB" id="10248617at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006386">
        <property type="term" value="P:termination of RNA polymerase III transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000006">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000011">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1070.20:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000019">
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    <keyword evidence="4 15" id="KW-0240">DNA-directed RNA polymerase</keyword>
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    <keyword evidence="6 15" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 15" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="45"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="18">
        <location>
            <begin position="193"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="20">
        <location>
            <begin position="452"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="21">
        <location>
            <begin position="552"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="22">
        <location>
            <begin position="634"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase subunit 2 hybrid-binding" evidence="16">
        <location>
            <begin position="681"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase subunit 2 hybrid-binding" evidence="16">
        <location>
            <begin position="1056"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="17">
        <location>
            <begin position="1089"/>
            <end position="1174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011206"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
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        <source>
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        </source>
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        <source>
            <dbReference type="RuleBase" id="RU363031"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF04566"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF04567"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH43022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="1177" mass="131268" checksum="88F9EB51818B1B89" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JLT4</accession>
    <name>A0A2H3JLT4_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RlpA-like protein double-psi beta-barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_121093</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="PCH42841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    </dbReference>
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        <property type="entry name" value="RlpA-like domain"/>
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    </dbReference>
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        <property type="entry name" value="Expansin_CellWall"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EXPANSIN-LIKE PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Barwin-like endoglucanases"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013816813" description="RlpA-like protein double-psi beta-barrel domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH42841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="126" mass="13722" checksum="B111C31108FA8C8B" modified="2018-01-31" version="1">MFRFQVIAAICTLSVGVIATPMLTHTKRQNVGEATYYYPGEGACGYYNTSDQPVLALSVDIWNNGEYCMQWVELTDPATGATQYGQVVDECQGCDSTHVDLSPSLFESLGAPLSQGVISPLDWQFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JM98</accession>
    <name>A0A2H3JM98_WOLCO</name>
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        <recommendedName>
            <fullName evidence="4">Peptidase C14 caspase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WOLCODRAFT_83448</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C14B family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467909">
        <property type="protein sequence ID" value="PCH37127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
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                <person name="Martinez A.T."/>
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                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
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                <person name="Ferreira P."/>
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                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
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                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
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                <person name="Ohm R.A."/>
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                <person name="Sabat G."/>
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                <person name="St John F."/>
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                <person name="Sun S."/>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
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                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
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                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
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                <person name="Ferreira P."/>
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                <person name="Foster B."/>
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                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
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                <person name="Lundell T."/>
                <person name="Martin R."/>
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                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
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                <person name="Sabat G."/>
                <person name="Salamov A."/>
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            </authorList>
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        <property type="match status" value="1"/>
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    </dbReference>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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            <begin position="74"/>
            <end position="542"/>
        </location>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <sequence length="559" mass="61114" checksum="D3A28C9D708B9392" modified="2018-01-31" version="1"> </sequence>
</entry>
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    <accession>A0A2H3JPS5</accession>
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    <protein>
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            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
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        </lineage>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
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                <person name="Martinez A.T."/>
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                <person name="Ferreira P."/>
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                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
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                <person name="Heitman J."/>
                <person name="Hesse C."/>
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                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH43901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="54" mass="6201" checksum="C82FDA9B3929FBC7" modified="2018-01-31" version="1">MTYAVIVGNSDVRAAHHDTEWKDKPSPLKHTEKKEYEWAQLHAIPSAPYQALQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JQ66</accession>
    <name>A0A2H3JQ66_WOLCO</name>
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        <recommendedName>
            <fullName evidence="4">RNA helicase</fullName>
            <ecNumber evidence="4">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">WOLCODRAFT_122346</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="4"/>
    <dbReference type="EMBL" id="KB468146">
        <property type="protein sequence ID" value="PCH43645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JQ66"/>
    <dbReference type="STRING" id="742152.A0A2H3JQ66"/>
    <dbReference type="OMA" id="EDQFGMM"/>
    <dbReference type="OrthoDB" id="10261375at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012541">
        <property type="entry name" value="DBP10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF8">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08147">
        <property type="entry name" value="DBP10CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01123">
        <property type="entry name" value="DBP10CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="17">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="29"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="16">
        <location>
            <begin position="268"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="267"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="735"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="13">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="771"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="811"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="828"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="840"/>
            <end position="862"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PCH43645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="862" mass="95167" checksum="FD744E3208248116" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JQG8</accession>
    <name>A0A2H3JQG8_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_162007</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468053">
        <property type="protein sequence ID" value="PCH39988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="93"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH40318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="315" mass="34475" checksum="77C29A0DBC0BBCE6" modified="2018-01-31" version="1">MASPAPDVLSGHHGHLAPDQDAALAAFKDILAAARLYTPAADGPASHDEPTLLRFLRARRFDPHKASKQFQESEAWRAQHRVDALYATFDPAEFEDARRFYPRWTGRRDKNGLPVYVYRLASLAPIKAELDAVPPPRRYQRIIALYETMTRFVLPLCSALPHPGAPTPVSAVTTIIDLAHVPLSALWGLRAHLGEASALATANYPETLAAIAVVNAPAFFPTVWGWVKGWFDEGTQRKVHVLGKDPGPTLRALIDAKDLPKPYGGELDWVFEDGPALDDAAKAVVGEMPKGPVVFQDGQVRRPQPPPEEGAESPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JRG4</accession>
    <name>A0A2H3JRG4_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WOLCODRAFT_137933</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB468124">
        <property type="protein sequence ID" value="PCH42483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JRG4"/>
    <dbReference type="STRING" id="742152.A0A2H3JRG4"/>
    <dbReference type="OMA" id="KPECTGQ"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05227">
        <property type="entry name" value="AR_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000085">
        <property type="entry name" value="Dihydroflavonol reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF564">
        <property type="entry name" value="STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="9"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PCH42483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="342" mass="37619" checksum="15ED97E55EBE4F5F" modified="2018-01-31" version="1">MPAVTTGKVLVTGANGFIAMWVVRTLLEQGYTVRGTVRSESKGAHLRQVFATYSDKLEILIVEDITKEGAFNEAVQGVDAVEHTASPFHFKADDPDELIVPAVHGTTRVLESVRTHGTSVRRVVVTSSCASVMQLQPEPRVFSEVDWNDAAIAEVRAKGRAAPQPAKYRASKTLAERAAWEFMERNKGSIGFDLVVLNPPYVFGPAIHEVGAPEALNESMHDWFHTVFKGSKTATQLSSVGSSWIDVRDLAEAHTLALKREEAGGERIIVSEGAFMWQDWVNAARVHGANVPAGDESYDHAKAVHSLRYDTSKAARLLGLKYRSIKESAKDMFEDFKARGWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JRL4</accession>
    <name>A0A2H3JRL4_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Splicing factor 3B subunit 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_23492</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH38647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JRL4"/>
    <dbReference type="STRING" id="742152.A0A2H3JRL4"/>
    <dbReference type="OrthoDB" id="438939at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015016">
        <property type="entry name" value="SF3b_su1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08920">
        <property type="entry name" value="SF3b1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Splicing factor 3B subunit 1" evidence="1">
        <location>
            <begin position="4"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH38647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="92" mass="10216" checksum="A4A6A227752FD234" modified="2018-01-31" version="1">MCIITGEELDAILPATGYAIVTPPPSYAPLISPLKPAMLVTEAGGFQIEESSDEPRRFLCGCRYWPCPGTPNRNLRHRQSRLLQGRRCTILC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JRS6</accession>
    <name>A0A2H3JRS6_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WOLCODRAFT_136894</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD-104</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB468053">
        <property type="protein sequence ID" value="PCH40468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JRS6"/>
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    <dbReference type="OMA" id="GTHIGIP"/>
    <dbReference type="OrthoDB" id="2094832at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051654">
        <property type="entry name" value="Meroterpenoid_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35897">
        <property type="entry name" value="METHYLTRANSFERASE AUSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35897:SF1">
        <property type="entry name" value="METHYLTRANSFERASE AUSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PCH40468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="314" mass="34436" checksum="8124848EC305A53A" modified="2018-01-31" version="1">MSTEVLSAPVRVTDANHTELQDAHEPDFALESLTEEELAFLKGQTGIQDDNGLKEHITNIQSDAMVVHPYGCIRHFVFTKLKISRLPAYRQMMKLAKERQGAVFLDIGCCFGNDVRKAVADGFPAQNAIGSDLHPEFWQLGQRLFGILPEQDPVKFLPGDALNTAFLEAVAPFSSPPTSPRPEISSLTTLNPLRGHVSAIHASAFFHLFDEVGQLELARSLAGLLSPEPGSIIFGAHNGQAEKGVLKGPSLHITTKNMFCHSPGSWVAMWDGVVFEKGKVKANAFLFALKEEEVNLGQGNSDQFHQLVWSVVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JRT3</accession>
    <name>A0A2H3JRT3_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Needs CLA4 to survive protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">UBA4</name>
        <name evidence="15" type="ORF">WOLCODRAFT_163919</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">MD-104</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="13">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="13">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">In the N-terminal section; belongs to the HesA/MoeB/ThiF family. UBA4 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB468124">
        <property type="protein sequence ID" value="PCH42613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JRT3"/>
    <dbReference type="STRING" id="742152.A0A2H3JRT3"/>
    <dbReference type="OMA" id="IPDVGMD"/>
    <dbReference type="OrthoDB" id="10261062at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070566">
        <property type="term" value="F:adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate-cyanide sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042292">
        <property type="term" value="F:URM1 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032447">
        <property type="term" value="P:protein urmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00757">
        <property type="entry name" value="ThiF_MoeB_HesA_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.250.10:FF:000014">
        <property type="entry name" value="Adenylyltransferase and sulfurtransferase MOCS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000033">
        <property type="entry name" value="Adenylyltransferase and sulfurtransferase MOCS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03049">
        <property type="entry name" value="MOCS3_Uba4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028885">
        <property type="entry name" value="MOCS3/Uba4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF102">
        <property type="entry name" value="ADENYLYLTRANSFERASE AND SULFURTRANSFERASE MOCS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 13" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 13" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9 13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Rhodanese" evidence="14">
        <location>
            <begin position="327"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate; for adenylyltransferase activity" evidence="13">
        <location>
            <position position="214"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine persulfide intermediate; for sulfurtransferase activity" evidence="13">
        <location>
            <position position="378"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="75"/>
            <end position="79"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="136"/>
            <end position="137"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00075323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PCH42613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="421" mass="44764" checksum="8551CB7F3BA9F3D0" modified="2018-01-31" version="1">MTRNASSAQLSLEDYRRYGRQMILNGFGLPGQLKLQQASVVVVGAGGLGCPALQSLAAAGVGRIGIVDHDTIELSNLQRQILHTESRVGTPKALSAAAAIKQINSRVHVETHATALTSANAIAVLSGYDIILDCTDNLPTRYLLSDTAVRLNRPLISGAAQQFDGQLCTYNLPLSSYASCSSSTGSDEEKDGVRGPCFRCLFPKPPAPEMAGSCEELGVLGAVTGVIGNLQALEAIKLFTGLHDSKPSLLIYSALNTPPFRSIKLRARRATCPACGDDGAKVGQIEETDYVAFCGGARPDWVSRGLVVEGRSDVRIHAKELKDVLESGRNVRIIDVRQPTEFGICHLPGSMNIPIKELVANPSAHLASEDGQETYVICRLGNDSQIAVDALRGAGAAGVMKDLVGGLRAWARDVDETFPVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JRV2</accession>
    <name>A0A2H3JRV2_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_163166</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
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            <strain evidence="2 3">MD-104</strain>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
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    </evidence>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
            <dbReference type="SAM" id="Coils"/>
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        <source>
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    </evidence>
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    </evidence>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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    <comment type="subcellular location">
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            <topology evidence="1">Multi-pass membrane protein</topology>
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    <dbReference type="OrthoDB" id="74314at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052816">
        <property type="entry name" value="Peroxisomal_Membrane_PEX28-32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010482">
        <property type="entry name" value="TECPR1-like_DysF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28304">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28304:SF2">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06398">
        <property type="entry name" value="Pex24p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="260"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="TECPR1-like DysF" evidence="6">
        <location>
            <begin position="97"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PCH39887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="457" mass="50708" checksum="D707A1E0D19F507A" modified="2018-01-31" version="1">MASLDYVEIPPYATRLQSAPDNDNLRAIPKVLTSLPRPEHAPAALAANTSSPTSSQPLSPSKAALNSIPQLLLSSAIQLPPTPRDATRGPLLSTRDPLSIPITTVNFRRFVSRIGPAFWLQDRLEEIVMWKKGTRYTAVWMAAYAFLCYFPRLVLLIPHICLLSVLLATHPSLRSAESAPEVPPPSTAPAGEGSGDWLANVQAIQNLMGAYSDAHDYVQPVIPHLTHATPYTPVILSATALSLVAFIPAVHLLPLRTTFLILGLAPLILTHPIVRLTLLPALLSSAQPLLTALRARLMRALDDDQLEDCHWRAELRDVELFENERWRRDEQGSAEGGWAKANLRTGERKPWTRGRDGWSGVSDDGGGDVSNLTFALSPGWKFVETEDWRPDLQGKWAAPASADAGGWVYTNDAWLDPRPLPSDEWRASGMTRRRRWIRRIYYSPMMLEDNTIDPRDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JUU7</accession>
    <name>A0A2H3JUU7_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">60S ribosomal protein L7/L12-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WOLCODRAFT_119329</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL12 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH41618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JUU7"/>
    <dbReference type="STRING" id="742152.A0A2H3JUU7"/>
    <dbReference type="OMA" id="LEDKWGV"/>
    <dbReference type="OrthoDB" id="250175at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00387">
        <property type="entry name" value="Ribosomal_L7_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1390.10:FF:000001">
        <property type="entry name" value="50S ribosomal protein L7/L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.710">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00368">
        <property type="entry name" value="Ribosomal_bL12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000206">
        <property type="entry name" value="Ribosomal_bL12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013823">
        <property type="entry name" value="Ribosomal_bL12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014719">
        <property type="entry name" value="Ribosomal_bL12_C/ClpS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008932">
        <property type="entry name" value="Ribosomal_bL12_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036235">
        <property type="entry name" value="Ribosomal_bL12_oligo_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45987">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45987:SF4">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL12M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00542">
        <property type="entry name" value="Ribosomal_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16320">
        <property type="entry name" value="Ribosomal_L12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54736">
        <property type="entry name" value="ClpS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48300">
        <property type="entry name" value="Ribosomal protein L7/12, oligomerisation (N-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein bL12 oligomerization" evidence="5">
        <location>
            <begin position="54"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein bL12 C-terminal" evidence="4">
        <location>
            <begin position="117"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PCH41618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="185" mass="19480" checksum="17653FEA422428AB" modified="2018-01-31" version="1">MASRCTTALRAISRTRSVARANAFASSSRCLATAAEASTSSAPPPPVASADPKLNKIVDDISGLTLLQAADLVSLLKARLNIQEIAMPAAAAAPAAPGAAAASEDAVEEKPKEKTIFTVKLESFDATAKPKIIREVKALVPNLTLIEAKKFVESLPQTLKENLPKEEAEKMQKTFTDLGAVVKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JV11</accession>
    <name>A0A2H3JV11_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_67498</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468053">
        <property type="protein sequence ID" value="PCH40554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JV11"/>
    <dbReference type="OMA" id="ENEPHIF"/>
    <dbReference type="OrthoDB" id="3263597at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="2">
        <location>
            <begin position="4"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH40554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="210" mass="23860" checksum="8A9570E231ACD43E" modified="2018-01-31" version="1" fragment="single">AVAVALTISLWDHALTIGDEIELVWRQPWTFLQLLVMINRYCGEASLIFIAYTFLRTHITTRCRAFGILVGAYCIINSASSQFALLLRIYGLWDGRKVVKYALVIGFVICFGITLTFAVATLGQTLDSLRYLQIINSCTTSAKLKSIVGVWGGMVLYDVYVFLLILTNEFTRPHRRNIDIIKALSRDGALTFLVRDIHILYCHKCNPFEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JVA3</accession>
    <name>A0A2H3JVA3_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_153955</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000218811">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH43903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="78" mass="8256" checksum="F27C8DF9659DEBA3" modified="2018-01-31" version="1">MSGLDMSMLQPEDLDLLAAPSSSSQSPLAATNNLQASWMINFSKLSTVVQTQPSGLPTIWVQGGSLKGALWSQTMCEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JVP1</accession>
    <name>A0A2H3JVP1_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">WOLCODRAFT_102874</name>
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        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468135">
        <property type="protein sequence ID" value="PCH42969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JVP1"/>
    <dbReference type="STRING" id="742152.A0A2H3JVP1"/>
    <dbReference type="OMA" id="SAMMYGF"/>
    <dbReference type="OrthoDB" id="10253736at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321">
        <property type="entry name" value="DEHYDROGENASES, SHORT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321:SF8">
        <property type="entry name" value="ESTRADIOL 17-BETA-DEHYDROGENASE 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH42969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="271" mass="29343" checksum="6172488DB619A6D1" modified="2018-01-31" version="1">MNLELQDVHVLVTGASGGIGVATCLLFLKQGAVVTAHYNTKSSTLEPLLAEYGATRIRTVQGNLTQEDEVIRMFSNDNYAFGPVQVLIVNHGYYPPNDVPVWQMSLEQWNSTMASNLTSSFLVVREYLRSLERATDAVKDRASVVLIGSTAGKYGEFGHADYSAAKSGLQYGLLLTLKNEIVKIAPKARVNAIAPGWVKTPMAEHALKNPEIVYRALATMPLKKVATPEDVANQVVVVSSSTISGHVTGQVIMVEGGMEGRLLNKPEDIIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JWL1</accession>
    <name>A0A2H3JWL1_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ankyrin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_132263</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JWL1"/>
    <dbReference type="STRING" id="742152.A0A2H3JWL1"/>
    <dbReference type="OMA" id="ILRYPIC"/>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH42238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="309" mass="34542" checksum="9478C7662F634FBA" modified="2018-01-31" version="1">MTPKLSLDTLPIEILYEIHHYAASQELPLVCRHLYAVFKFAPSSVHAEYLLRRCHTGNPASLISLVLRYPLCTQSVIEAILRSPACPPSVQKDRQLPLELPRRLFRTLAPRPSGTPLHNRHRRQSREGWSENDHPLPFLRYLYDHPRFPAPDTNAHDGYALTRAVHAGFMPLVRFLLENGASPAYKDGLAVMVAIRQKDLSMVRLLIERDGRQRVGATAERRGKADADTEPRGIAAMDAELARKRGGAQAQGAISAKKRRLEDRMTATPAMLKMAVKSGAQDIANYLVQEKGCVPDMRTIDLLGYARGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JXA1</accession>
    <name>A0A2H3JXA1_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ARM repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WOLCODRAFT_138414</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
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            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
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                <person name="Martinez A.T."/>
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                <person name="Glotzer D."/>
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                <person name="Heitman J."/>
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                <person name="Jurgens J.A."/>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Kallen N."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
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                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
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                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
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                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
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                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
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                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
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            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">MD-104</strain>
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</entry>
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            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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        </citation>
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    </reference>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="178" mass="19620" checksum="8E31279A80D09130" modified="2018-01-31" version="1">MHLTPVSLPQIVRHDVGQGQDATARCFEPEASVHICHRVVSWPATPIALERHSQTYLLTTASRQATVELAYHPPARVAHRGCRPLLPLLPPSMRSASILLRMPDCRCKLLAGARRVEHCANPSPAVVAMLRSHGALLIKELVLIERSLYHDVHIESHKGPNMRQCGVIGPRTVISALL</sequence>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Barry K."/>
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                <person name="Gorecki P."/>
                <person name="Heitman J."/>
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                <person name="Hori C."/>
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                <person name="Jurgens J.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD-104</strain>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="AtrR-like"/>
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        <property type="entry name" value="XnlR_reg_dom"/>
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    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
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    <dbReference type="PANTHER" id="PTHR46910:SF3">
        <property type="entry name" value="HALOTOLERANCE PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="75"/>
            <end position="103"/>
        </location>
    </feature>
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        <location>
            <begin position="24"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="168"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="237"/>
            <end position="278"/>
        </location>
    </feature>
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        <location>
            <begin position="837"/>
            <end position="876"/>
        </location>
    </feature>
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            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
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        <location>
            <begin position="168"/>
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        </location>
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    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="189"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="237"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="857"/>
            <end position="870"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH42644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="980" mass="107667" checksum="1DB392D48CCAE59D" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K0X6</accession>
    <name>A0A2H3K0X6_WOLCO</name>
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        <submittedName>
            <fullName evidence="8">GTP-binding protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WOLCODRAFT_104119</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:translation elongation factor activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="GTPBP1_like"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GTP-binding elongation factor Tu family"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Probable GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000091">
        <property type="entry name" value="Probable GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
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        <property type="entry name" value="GTPBP1-like"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
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        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
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        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004160">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721">
        <property type="entry name" value="ELONGATION FACTOR TU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721:SF9">
        <property type="entry name" value="GTP-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03143">
        <property type="entry name" value="GTP_EFTU_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
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    </dbReference>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="7"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
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        </location>
    </feature>
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        <location>
            <begin position="55"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PCH43758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="621" mass="67933" checksum="1C7587864FD658D7" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K3G2</accession>
    <name>A0A2H3K3G2_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WOLCODRAFT_102830</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468135">
        <property type="protein sequence ID" value="PCH42947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="742152.A0A2H3K3G2"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24409:SF356">
        <property type="entry name" value="C2H2 FINGER DOMAIN TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24409">
        <property type="entry name" value="ZINC FINGER PROTEIN 142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="389"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="4"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="61"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="100"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="236"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="273"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="292"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PCH42947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="420" mass="46731" checksum="16525D77A50CD2D9" modified="2018-01-31" version="1">MQLFRCDPCGSYFESVRALQNHGKTSPRHVIDYGRRCLQCGSVYSSPASLIQHYVESPLHYYCSRCDEHFERDSDYVSHKLYRHNGSDAAPNNVSPDAIWYCTECNLAFQTRDDLYMHWESTTHTTQQYTCPGNDCSKTFGTPSAVIQHLESGACASGMTRQRVNRMAIAADRGAVITDRARIAADNERLSMPEPVATTAWFNGSSFECIICHRTCQSLVGLNRHLRSPAHSEKIFKCPQQWSGCGKAFNTLSGLVQHVESGVCGVRRFAPEMSSGGGERLQISFSDEETTGRTSGTSQYPLRTEPAGSSSPSYTQRSAYEEPRQSFSEPRSYVPVASLQSGTYTYQRPQQPSIPTYQRSQQSSSCGMIVRAVITITILFWSIKFLAVVVAVSLGGVILSAILISCIYSLLVRLGRRLMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K3W2</accession>
    <name>A0A2H3K3W2_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WOLCODRAFT_138555</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468146">
        <property type="protein sequence ID" value="PCH43734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K3W2"/>
    <dbReference type="OMA" id="GKPRCDH"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF3">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="47"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="92"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="121"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="131"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PCH43734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="476" mass="52619" checksum="93376AA234C0CB93" modified="2018-01-31" version="1">MSMAGSPDGTESVGESGDDGQLTIRIPNPKVYMARQSQWKGRRGKPRCDHCRLNNLKCDRVLPACNHCAFPGSGRECKYTPLPTPAHRGIPRCDRCRSKNLKCDRNLPVCNHCADENEDDCNYTPKKRHKVPSDHTTTKDRPVAPYTAKTASFLVSDVPSNGSGDPSPEGSAGSGPSRGSPHPLDQEDDIGMPPDADTEMFQQVGPDGAITWVRKIALPPLASKGAASHTYHRPFLLDQGMIVTTPHIDPWMHPAFAPLPDIVLQTLTSVNAIEMPSRHAFDEALMRFVGGLAPELRETATFMPDLYAEIAHAVSEGLVANLSPRLQLWATCHHARSGSRRHHLIVLPRDNFYNMTRADEEKLRAMYITQADGEVDPAKVEQTAEGAPGPVDALAAFERVPVQQQIYDILVYTHRTHSSAAEMLKEARRIGIATVTWPMVELFVRLCPLCKMRAKGHPRAVPEEDPVLFRQPIPKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K532</accession>
    <name>A0A2H3K532_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_144554</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468146">
        <property type="protein sequence ID" value="PCH43527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K532"/>
    <dbReference type="STRING" id="742152.A0A2H3K532"/>
    <dbReference type="OrthoDB" id="3056235at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH43527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="402" mass="45193" checksum="4D131B2C952DD288" modified="2018-01-31" version="1">MSSQLAMSAFQNHVRDSSSQLGYRVRIPTQELDKAEKWSSVPRDAGHEDKSFSVKAVLQTGSPRLPSGSHYSRSRSSCTRLRQICMLYCALSCVLFFMSLCTRYYDKSPVDIIVTTNAIDPFVIRAATENADITACIWATDHDIGSIFAWAARWSGPISLLMVTTVEPASEEHENLLRKLSAQQNRSTLLNGTLTLHLAHLSPQTPDNPNAFLNLARLFSQTPRVALFPANLSTLPPKSLYKSLVSHSTVSSAAILEPTRPKHRPIILTARGQTGFPFSPMAPLVMGRDDPLWCTERFFPPTTREEDWEKCLWQVWLENFGDVEVRQTRGWFHDMISMPTSDPFVASGLRHRLVAKYRSETCVLATRQLAALRSTDKELDAKKARWLKRVCRAWTNAAQSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K678</accession>
    <name>A0A2H3K678_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_75035</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="215"/>
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    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH43937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="215" mass="24631" checksum="C28D239D860D595E" modified="2018-01-31" version="1" fragment="single">MILGTFRTTPIDSHEHLASILPIPLTLHQIVTQNAIRTCTLPTNSLIHNRRYSNIRQPFPLTIQTINKTYPYTNPITYIHHLLPTDTERIDPFVQAPWDRQPKWGTHLQFDTIAQKSMKQEHITHHCHIQHLIDIIATNPTHLTIYTDRSSHTPRYRRKPHTGAALLVTHLSKHIHEEARGLGIQAMLFDAELCAAALAANRILDILPSHIHLTT</sequence>
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    <accession>A0A2H3K701</accession>
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        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
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                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
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                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
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                <person name="Wiebenga A."/>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
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    <accession>A0A2H3ISS5</accession>
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        <submittedName>
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            <taxon>Agaricomycotina</taxon>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
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                <person name="Lundell T."/>
                <person name="Martin R."/>
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                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
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                <person name="Wiebenga A."/>
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        <property type="entry name" value="B30.2/SPRY_sf"/>
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        <property type="entry name" value="ConA-like_dom_sf"/>
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        <property type="entry name" value="CRA_dom"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="250"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="CTLH" evidence="3">
        <location>
            <begin position="610"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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    <feature type="region of interest" description="Disordered" evidence="1">
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    <feature type="region of interest" description="Disordered" evidence="1">
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    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="603"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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            <end position="112"/>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH33036.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="848" mass="90254" checksum="E33489701B1809CC" modified="2018-01-31" version="1"> </sequence>
</entry>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
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                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
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                <person name="Larrondo L.F."/>
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        </citation>
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            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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        </location>
    </feature>
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        <location>
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            <end position="13"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="PCH33136.1"/>
        </source>
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        </source>
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</entry>
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        <submittedName>
            <fullName evidence="15">Cytochrome P450</fullName>
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        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
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                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
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                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
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                <person name="Sabat G."/>
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                <person name="Syed K."/>
                <person name="Tsang A."/>
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            </authorList>
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            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
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    <comment type="pathway">
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
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        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="398"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="461"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="461" mass="51586" checksum="6ED761E2ABE475DE" modified="2018-01-31" version="1" fragment="single">LPPGPAPLPIIGNTLHIPQVHPWLTYSKWAKTYGDLIHLDVLGQSIIVINSSEIANDLLDKRSSKYSDRPRLATGYNQVFVMRGYDNEWRRRRKIVTQGFSQAKIPNYFSLQELAACKLTLDLIDDPTHFVNHVKFHTISITARVTYGYDVKDLSNPLVAKILKGVENLSEASVPGTWAVDFLPQRESTRMPHGISIIGANKARYDSLQALHSSQTYPLSKLNNTAITPSLCSKVLTESENALSKEGESDLAWSANMIMGGGTETNISTTLTFILAMVLYPEAQKRAQAEIDSVIGPNHLPTIRDKPSLPYVRSVIAEVFRWNPAAPLAAVHSMSEEDVYNGYYLPKGSMILPNVWHMTHDPEQYSEPMEFKPERYQYDDAQMTKVMSLGFGFGRRACPGSHFAESTFFAMVSTILACCNIMPAKDEHGNVIIPEIEYSTGMIVFPKEFKCNIEPRSSRVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IWW6</accession>
    <name>A0A2H3IWW6_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_15352</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">MD-104</strain>
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    </evidence>
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    </evidence>
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</entry>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
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                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
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                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
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                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
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                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
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                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1221748"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">MD-104</strain>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
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                <person name="Martinez A.T."/>
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                <person name="Spatafora J.W."/>
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                <person name="Benoit I."/>
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                <person name="Ferreira P."/>
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                <person name="Gaskell J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Morin E."/>
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                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
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                <person name="Sabat G."/>
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                <person name="Schmutz J."/>
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                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
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                <person name="Pisabarro A."/>
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                <person name="Martin F."/>
                <person name="Cullen D."/>
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            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">MD-104</strain>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IXR0</accession>
    <name>A0A2H3IXR0_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">2-(3-amino-3-carboxypropyl)histidine synthase subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WOLCODRAFT_78992</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase, predominantly CBR1. Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase. Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the 2-(3-amino-3-carboxypropyl)histidine synthase complex composed of DPH1, DPH2, DPH3 and a NADH-dependent reductase, predominantly CBR1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the DPH1/DPH2 family. DPH2 subfamily.</text>
    </comment>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="P:protein histidyl modification to diphthamide"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DPH1/DPH2_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042265">
        <property type="entry name" value="DPH1/DPH2_3"/>
    </dbReference>
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        <property type="entry name" value="diphth2_R"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DPH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762:SF2">
        <property type="entry name" value="2-(3-AMINO-3-CARBOXYPROPYL)HISTIDINE SYNTHASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01866">
        <property type="entry name" value="Diphthamide_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01121">
        <property type="entry name" value="Diphthamide_biosynthesis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00408">
        <property type="entry name" value="Diphthamide_biosynthesis_famil"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00032">
        <property type="entry name" value="Radical_SAM_3-amino-3-carboxyp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 10" id="KW-0408">Iron</keyword>
    <keyword evidence="7 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
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        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="494"/>
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        </location>
    </feature>
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            <begin position="200"/>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00054092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PCH34780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="515" mass="57292" checksum="8395A1D150E3C1C1" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IYA1</accession>
    <name>A0A2H3IYA1_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">WOLCODRAFT_165936</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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        </location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH34980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="677" mass="74884" checksum="92CB05F222C152BB" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J004</accession>
    <name>A0A2H3J004_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
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                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
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    </evidence>
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            <taxon>Phaeolaceae</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
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                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
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                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
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                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
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                <person name="St John F."/>
                <person name="Stenlid J."/>
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                <person name="Sun S."/>
                <person name="Syed K."/>
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                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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    </dbReference>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH36681.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="108" mass="11845" checksum="579392A41E7EFD82" modified="2018-01-31" version="1">MSKNIDNTEILCTSTRKHKATKKQVQLDEDARWHQTAAVVATIPAVETTNGSESSLDSQSDFEEGIGGSTKQQTVEQDDGVQVRFVQKGVDGKTISEEQNGCWCLICK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J4G5</accession>
    <name>A0A2H3J4G5_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Kallen N."/>
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                <person name="Kohler A."/>
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                <person name="Kumar T.K.A."/>
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                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
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                <person name="Slot J.C."/>
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                <person name="Stenlid J."/>
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                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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    </evidence>
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    </evidence>
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</entry>
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    <accession>A0A2H3J5V0</accession>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Barry K."/>
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                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
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                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
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                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
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                <person name="Kallen N."/>
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                <person name="Kuees U."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD-104</strain>
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    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
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    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily.</text>
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    </dbReference>
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        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
    <evidence type="ECO:0000313" key="6">
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        </source>
    </evidence>
    <sequence length="302" mass="33823" checksum="3DD1D98AFD905953" modified="2018-01-31" version="1">MSPSKPEIRPESQVDPALIRPLDPSLFAPSEREAAFLRTTISEDETEVKRRVMEVQEEAYARYPYPCIRIFHHVSLMMSANPVYPMVLEGGKKGDTYFLDLGCCMGTDVRKLAQDGYPASHVLGCDLRPEFIELGYKLYADRDSCPVRFFASNIFDVPVSFSPTSSNETSISATPTELAQLTGSLTHIYTGALFHLFDESTQFAIALRLATLLKRESGAVIFGRHSGLEEAGKIDDHLGRNRYGHSEQSWPLLWKSVFAEAEGPEFAESRLRVEAKLGPEFPKHLFGVSRSGRMLVWSVQIL</sequence>
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    <name>A0A2H3J6P0_WOLCO</name>
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    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="PCH37920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J6P0"/>
    <dbReference type="STRING" id="742152.A0A2H3J6P0"/>
    <dbReference type="OMA" id="GIATCTE"/>
    <dbReference type="OrthoDB" id="4991875at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013803341" evidence="2">
        <location>
            <begin position="23"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="187"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH37920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="256" mass="25453" checksum="D4BE0A83F67B693B" modified="2018-01-31" version="1">MAISGYFKLLVSLSLCARYASATSSLYVPGFDPQPITVNELGVGSDGATTYIIAPGVTSGTLDQYGIFGPATLVEASATASLYYEDPSIGAEMSESCQINNGIAVCVDGVAVPDAYGIGGYTTTYTVEEVVQSFAIQGGGKATGTAAIATTPTSTPYYSTSFATAGTSDGGVWGSGYASYGTVPTASVPTADSSSSDADTSSTGSSMTRVPVSSTAAPSTTSGVSQDTKNSGVGKLSAFPLVSLLVAGSSAILMLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J750"/>
    <dbReference type="Proteomes" id="UP000218811">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH35603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="120" mass="12023" checksum="691BD4DA327052CA" modified="2018-01-31" version="1">MIRSQTSVGSCSGLLEDGSLPVSVAPGTRPMCLHPGCRTSSAPSALRGPPFSFGASCLASPLVADTFSRAACTAPPASGSLSRSFNLILDLSSVASTLARFVGLSVATGLSTTSYGLMVP</sequence>
</entry>
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    <name>A0A2H3J7K6_WOLCO</name>
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    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL15 family.</text>
    </comment>
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        <property type="protein sequence ID" value="PCH33618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <property type="entry name" value="Ribosomal_eL15_CS"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11847:SF4">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL15"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PCH33618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="201" mass="23982" checksum="9F3F96E57E034129" modified="2018-01-31" version="1">MGAYKYIGELYKKKQSDVLRFLLRVRCWEYRQLNVIHRASRPSRPDKARRLGYKAKQGYVIYRVRVRRGNRKKHVPKGATYGKPVRQGVNHLKPQRGLRSVAEERVGRRCGNLRVLNSYWINQDGVYKYYEVILVDPNHKAIRRDPRINWITKPVHKRREARGLTSIGKQNRGLGKGHRYNHTPGWSTWKRHNTLSLRRYR</sequence>
</entry>
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            <fullName evidence="4">BTB domain-containing protein</fullName>
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        <lineage>
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            <taxon>Agaricomycetes</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH37735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J7Y3"/>
    <dbReference type="OMA" id="LAPHYWS"/>
    <dbReference type="OrthoDB" id="3366352at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH37735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="338" mass="37102" checksum="5CAE9D547CE4E17E" modified="2018-01-31" version="1">MHGFPFVPRPFPPPALADVPLEYIIDQLRRLASHYWSKPETSDCTIVVPLDTKAAVPTETGVAPGPSHGAGEFGLSQQAEEPAPRPTPRMVMQLHMDYLCAHSALLRGLLSGASPFDLIDGSSASPISSRPSSTSGAAPQRAPLFPSLLPSSPTHPSILLPVPDPASFRLLVHYIYFGSTSYIEDALDDGTLSWEGIARNVEYLGMGAEIKIFLGRWYGRWRRGRASEGYSGAYTSDSESEAGDDSDDDDYEREQEVEMLAPHDPLSAATSPTVFDPDEEYYKDKGEQVVWEVPRNPPRGRDRTTRRLGHSTSAPTLGQGNSRLFMQDSFRTPRGRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J8K3</accession>
    <name>A0A2H3J8K3_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyclin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_96815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH38261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J8K3"/>
    <dbReference type="STRING" id="742152.A0A2H3J8K3"/>
    <dbReference type="OMA" id="WEDVWSV"/>
    <dbReference type="OrthoDB" id="10264655at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20532">
        <property type="entry name" value="CYCLIN_CCNL_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036580">
        <property type="entry name" value="Cyclin_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin N-terminal" evidence="1">
        <location>
            <begin position="26"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH38261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="297" mass="33890" checksum="C55F3F16F50FB039" modified="2018-01-31" version="1">MSTALYPLASLEQIEKTPSREDGIPYELEEDLRAHGCKLIHEAGILLKQKQVAVATAQILFQRFWYVTSMKQFGIGDIGMGALYLASKLEECPVRMRDLINVYDLLQQRTAHTRATMIASASAPSSSSHPTKEFRYTPMSYFGSTFYDLREALVIAEMQVLKRLGFNVHVVLPYGTLVNYLRVLGLTDRTDVCTRAWGYLNDALQTPVYALYAVPTIVCAAILLTVRHLGIALPSAPENRWWELFDAEWEDLWSVCGYIMRLYRDRSIEDRTRVMGMLSKKGVRQWLDEHKTVDPQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J8S5</accession>
    <name>A0A2H3J8S5_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">UDP-N-acetylglucosamine transferase subunit ALG13</fullName>
            <ecNumber evidence="4 12">2.4.1.141</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 12">Asparagine-linked glycosylation protein 13</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ALG13</name>
        <name evidence="15" type="ORF">WOLCODRAFT_114684</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 12">Involved in protein N-glycosylation. Essential for the second step of the dolichol-linked oligosaccharide pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>an N-acetyl-alpha-D-glucosaminyl-diphospho-di-trans,poly-cis-dolichol + UDP-N-acetyl-alpha-D-glucosamine = an N,N'-diacetylchitobiosyl-diphospho-di-trans,poly-cis-dolichol + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23380"/>
            <dbReference type="Rhea" id="RHEA-COMP:19507"/>
            <dbReference type="Rhea" id="RHEA-COMP:19510"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57269"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58427"/>
            <dbReference type="EC" id="2.4.1.141"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 12">Heterodimer with ALG14 to form a functional enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the glycosyltransferase 28 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.141" evidence="4 12"/>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH38035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J8S5"/>
    <dbReference type="STRING" id="742152.A0A2H3J8S5"/>
    <dbReference type="OMA" id="QYKFRPN"/>
    <dbReference type="OrthoDB" id="20273at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004577">
        <property type="term" value="F:N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039042">
        <property type="entry name" value="Alg13-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007235">
        <property type="entry name" value="Glyco_trans_28_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12867">
        <property type="entry name" value="GLYCOSYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12867:SF6">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYLDIPHOSPHODOLICHOL N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04101">
        <property type="entry name" value="Glyco_tran_28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl transferase family 28 C-terminal" evidence="14">
        <location>
            <begin position="22"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00024804"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU362128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PCH38035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="199" mass="21257" checksum="7FFE3269C930B4B9" modified="2018-01-31" version="1">MSDPEPPSNQPPATESSPTPGHVFVTVGSTRFDELVQAVLDAPVLGALRARGHSRLVVQCGNSEFDAGAFARAGEDWVRTAENGLEITVWRFKPSLEGEYEHAELVISHAGSGTILDVLRLGKPLIVVPNPSLLDNHQEELATALASLGHLKAATIAGLPEAIVSLADAKLVPFPPFNGSRFRELLDEEMGYLPSDSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J8W1</accession>
    <name>A0A2H3J8W1_WOLCO</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
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    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH38650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J8W1"/>
    <dbReference type="Proteomes" id="UP000218811">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH38650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="124" mass="13852" checksum="116C5D759977B8ED" modified="2018-01-31" version="1">MAEYDIADSHRGMAESLCDIRPVAISTYSALAHAIGERYITIRHNEAINPEGEDREQVPLTPYSYKTRVDKAKERTFHLNDGQGVRVDHGAQEDYGKLNGALAPCRGVNERTRATDILMISSTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J8X4</accession>
    <name>A0A2H3J8X4_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Cytochrome P450</fullName>
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    </protein>
    <gene>
        <name evidence="15" type="ORF">WOLCODRAFT_82165</name>
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    <organism evidence="15 16">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
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                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">MD-104</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis.</text>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OMA" id="REVLITH"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="446"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PCH36253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="521" mass="58987" checksum="1B185D90F117FA96" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J999</accession>
    <name>A0A2H3J999_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Taurine catabolism dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WOLCODRAFT_167649</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467943">
        <property type="protein sequence ID" value="PCH38832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J999"/>
    <dbReference type="STRING" id="742152.A0A2H3J999"/>
    <dbReference type="OMA" id="FTTHIVE"/>
    <dbReference type="OrthoDB" id="10257314at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000005">
        <property type="entry name" value="TfdA family taurine dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051323">
        <property type="entry name" value="AtsK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468:SF10">
        <property type="entry name" value="TAUD_TFDA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="7">
        <location>
            <begin position="39"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PCH38832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="357" mass="40109" checksum="AACA6796489C3EA9" modified="2018-01-31" version="1">MSNTQTSTEIKSQAGTLSVRASTVPLVPTGALDKYEHIDLTPVIGREYPNVQLTDLLKAENADELIRELAIIVSQRNVVFFRNQDIDIEQQKLLGNKLGILSGRPQSSGLHIHPKDPPSQAPDPEIHVITSKANKKKEYENEGDISRLASREWHTDITFEPVPSDFAILKIHTLPEIGGDTLWASGYEAYDRLSPAFAKHLEGLTALHSAKKFKLFADAEGFGIHEGPRGNPENVGSELQAIHPIVRTNPVTGWKSLFVNKIFTKRILELTKDESDATLAYLNRIVADNHDLQVRFRWNKNDVAIWSNTSTFHTVTRDYGDELRQGDRVVSLGEKPYFDPASKSRREALGLKRWFDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J9I2</accession>
    <name>A0A2H3J9I2_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WOLCODRAFT_110252</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB467943">
        <property type="protein sequence ID" value="PCH38856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J9I2"/>
    <dbReference type="STRING" id="742152.A0A2H3J9I2"/>
    <dbReference type="OMA" id="ARVCTFA"/>
    <dbReference type="OrthoDB" id="1935484at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000106">
        <property type="entry name" value="MFS transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF65">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="319"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="382"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="419"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="451"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="45"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PCH38856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="521" mass="59956" checksum="93E821E95F015E8B" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JA60</accession>
    <name>A0A2H3JA60_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_29407</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467965">
        <property type="protein sequence ID" value="PCH39152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JA60"/>
    <dbReference type="OMA" id="FKHAGYG"/>
    <dbReference type="OrthoDB" id="9876299at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05325">
        <property type="entry name" value="carb_red_sniffer_like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052184">
        <property type="entry name" value="SDR_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458:SF1">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE SDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH39152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="232" mass="25176" checksum="746CF8BEB30D24C3" modified="2018-01-31" version="1">MSVTWLVTGCSRGLGFELVKQLASESSNIVIATCRNPDRATALQDLRYGAIGMLHIVQLDVTDEESIYASVQIVEDIVKEKGIDYLYNNAGIDNEDNAFNIKSEDLLRILRTNVVAPALISQVYLPLVERSARKVIVNVSSSFGSIGVDKGPYLAAYSISKAALNMLTYKQAVAKPNITVIALDPGWTKTDMGGPSAALEPHESVAQQIQVVTSAAKDSGRFLNYSGRILPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JAC4</accession>
    <name>A0A2H3JAC4_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WOLCODRAFT_158405</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase family. RimJ subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB467943">
        <property type="protein sequence ID" value="PCH38871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JAC4"/>
    <dbReference type="OMA" id="GRRACEI"/>
    <dbReference type="OrthoDB" id="64477at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051531">
        <property type="entry name" value="N-acetyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43792:SF8">
        <property type="entry name" value="[RIBOSOMAL PROTEIN US5]-ALANINE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43792">
        <property type="entry name" value="GNAT FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G00765)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="5">
        <location>
            <begin position="118"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="292"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="294"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="348"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="358"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PCH38871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="417" mass="46455" checksum="C4A224416C73554C" modified="2018-01-31" version="1">MSEDNNIVLEDNLQATTVLSGALFEAWREISPYSVEAAQADNPDIFTFSVDNCMYLAAITKWVVHEKKEDADPQHNEDLLISGGEHRDQWISHDTEIDDPWDSSSPVVETPCKNITHEDRWETIGLVYLGASSMQSEANIGISLIPDWRGKGLAVSALRRTLEIAFDVFQCHRVQARIMDGPHCIAARTIFIGLGFTFEGTRRRAVQTTTVGSPRDVGWRDVTYMALLDTEWVVRSSTRAAPQSAWDEMLNRHQREQEQLAGLENARILRRTLSSETIRKSRPEVTEYVPEWPSSASESRVSMSENESIIPSSPSFPIGSSESIPSSPSSYTGSMAEMQATEEEEELEIKTTVKVRVEEEEEEEEEEEEEVGTEVEETVGEGEEEGAEGSSTYRIMLSVIPMGIALTGAQTGVLSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JAQ6</accession>
    <name>A0A2H3JAQ6_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Indoleamine 2,3-dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WOLCODRAFT_129186</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the indoleamine 2,3-dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467987">
        <property type="protein sequence ID" value="PCH39352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JAQ6"/>
    <dbReference type="STRING" id="742152.A0A2H3JAQ6"/>
    <dbReference type="OMA" id="HVLAWIM"/>
    <dbReference type="OrthoDB" id="540174at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033754">
        <property type="term" value="F:indoleamine 2,3-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000898">
        <property type="entry name" value="Indolamine_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037217">
        <property type="entry name" value="Trp/Indoleamine_2_3_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657:SF5">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01231">
        <property type="entry name" value="IDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140959">
        <property type="entry name" value="Indolic compounds 2,3-dioxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="343"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="366"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="binding site" description="proximal binding residue" evidence="4">
        <location>
            <position position="443"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600898-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PCH39352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="494" mass="54425" checksum="98629AE659676037" modified="2018-01-31" version="1">MDFLFPLPPNLPPEHFLALPRPDHGQAAVGTPDTSTLAAHDFDVDTRTGFMPPQPPLVRLPEEWEPWETILDDALARRMKLADKKDITPDDEARSEQWRARVRELPIIQTAGLTRSEILLRRAHHVLAWLMHLYVHTLPRSTPDIRIPPPITVPLLQVSAQLQLPPVLTYSDDVLYNWAYKVPPSPAFPVRPPALDNLRCLTLFTGTRDEEEFYLASARIELRGVEALSLMRAIMDEAFLGDSTAIRRITAYLHSLARVIADLTPILAAVREGCDPEVFYNDIRPWFKGADSDAARKWVFEGLERDPTLQEPTELSGPSAGQSSLIHALDVFLGVDKNTHSNFLAEKPAPASGPASPANPAPPAQAPSAAAPTTTFSSAPGTTSVPFLTRMQSYMPRHHRAFLRHLSASPRPLRTLVEAAGDAPLLEAYNAAVTALKVFRDAHVRIVALYILGPSKRARGLMGQPEKGTGGTDAFKFVKGVRDQTAGALLRNTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JAX3</accession>
    <name>A0A2H3JAX3_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_129172</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467987">
        <property type="protein sequence ID" value="PCH39346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JAX3"/>
    <dbReference type="OMA" id="RFTHEDD"/>
    <dbReference type="OrthoDB" id="2795234at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="2">
        <location>
            <begin position="3"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH39346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="266" mass="30102" checksum="0F3FB8B040C4D844" modified="2018-01-31" version="1">MSCYDYFLTLDREIKFIWKADLSFATLLFYSCRYPILLNALLEVLGRVTWGWQNVEVRLFASLRVYAMYGRSKWLFAVVLFIGLISPIIWIYVFIRTSPRQNGIDGFWSCTLIILGPYESYEKGVMGARAASLLSDAIVLVLTCIKTARRSTIKAVTLGDRLSTLGDILLKDTAICFSFLCVINIFALATGRIPLLIEICTTWAAVLSSILLSRLALDLHEVHAAENDEETEFLSRTLRFTHEDDPSYMHFASDDDDDGSIIPNQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JB12</accession>
    <name>A0A2H3JB12_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH33137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JB12"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH33137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="289" mass="34185" checksum="F8A855B6C21EA388" modified="2018-01-31" version="1">MPADRFQKSVKQVKVTLRKGPLFHKEKKSYQSQAAPPSKMVVTNTATGQPELWDIKPWSVKQVKDLIPDNRYWGPKWYPADPPQRIEVNHTPEEREALLWKCYEESDHLREQAKLLRAEHAHKRHLEVEAEQAYLDKVVARYPGYHPTLPTPSKLFNRVLSEESAAHIAKMVQIEPEWMKDHMHLLPDETVRDRIAITYKKYEWALRLLPILEETDRILNQLYRLILDDPSMFHQEKDSQDVVHQIQRYRTFYKSFFMATLYGEVSNKELWEIERDADTILSSMYCVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JB87</accession>
    <name>A0A2H3JB87_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Taurine catabolism dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WOLCODRAFT_158391</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467943">
        <property type="protein sequence ID" value="PCH38855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="742152.A0A2H3JB87"/>
    <dbReference type="OMA" id="WNKNDMA"/>
    <dbReference type="OrthoDB" id="10257314at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000005">
        <property type="entry name" value="TfdA family taurine dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051323">
        <property type="entry name" value="AtsK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468:SF10">
        <property type="entry name" value="TAUD_TFDA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="6">
        <location>
            <begin position="40"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PCH38855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="358" mass="40387" checksum="05A3D02D503CEEBB" modified="2018-01-31" version="1">MSNIQTTTQTSVQSSGSISVRASTVPLKPTGALDKYEHVDLTPVIGREYPNVQLTDLLNAENADELIRELAIIVSQRNVVFFRNQDIDIEKQKLLGNKLGILSGRPQNSGLHIHPTTQPTSELGLEISVITSKNPKKKEYESELDISRFASREWHSDITFEPVPSDFAILKVHTLPEVGGDTVWASGYEAYDRLSPALAKHLEGLTALHDARQFKIYAKHIGITLNDGPRGNPENIGTSLQTIHPVIRTNPVTGWKALFVNKNFTRRILELTKDESDATLDYLHRLVTENHDLQVRFRWNKNDVAIWANSASFHNVTRDYGDEFREGNRVVSLGERPYFDPTSKSRREALGLKRWSDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JB88</accession>
    <name>A0A2H3JB88_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_159625</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
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    <comment type="function">
        <text evidence="12">Specific in hydrolyzing the terminal glycosidic bond of polygalacturonic acid and oligogalacturonates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[(1-&gt;4)-alpha-D-galacturonosyl](n) + H2O = alpha-D-galacturonate + [(1-&gt;4)-alpha-D-galacturonosyl](n-1)</text>
            <dbReference type="Rhea" id="RHEA:14117"/>
            <dbReference type="Rhea" id="RHEA-COMP:14570"/>
            <dbReference type="Rhea" id="RHEA-COMP:14572"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58658"/>
            <dbReference type="ChEBI" id="CHEBI:140523"/>
            <dbReference type="EC" id="3.2.1.67"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.67" evidence="13"/>
    <dbReference type="EMBL" id="KB467931">
        <property type="protein sequence ID" value="PCH37443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JCA7"/>
    <dbReference type="STRING" id="742152.A0A2H3JCA7"/>
    <dbReference type="OMA" id="NGQPWWS"/>
    <dbReference type="OrthoDB" id="187139at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047911">
        <property type="term" value="F:galacturan 1,4-alpha-galacturonidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736:SF12">
        <property type="entry name" value="EXO-POLYGALACTURONASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 15" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 15 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013568109" description="galacturonan 1,4-alpha-galacturonidase" evidence="16">
        <location>
            <begin position="21"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PCH37443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="429" mass="46364" checksum="AF385959A7799491" modified="2018-01-31" version="1">MLYASCLLLVASLWLGRASGDHVPRGTNNTCTVAPLGEGQDDTDQIEAAIEECGHYGTTVFSEGVYNVTRKMTWDLVASRVDLHGYLNFTADLPYWMDPANTYRVIFIQSQASWFVLTGSDFVVDAYNTGGIIGNGQYWWNWYGTGSRLDGDGRPVALTVYQATRGTIANFRIEGQPFWCNAIAESQDVIYDGMYCNATNTNPEYYGDNVVPNTDGIDTFRSDNITLLNWDITLGDDCLAIKGNSTNIYARNITCRGGNGIAFGSLGQYADLFDHVGNVTLEDTHMVRLSSEIQPNMGSGVYFKSWSGTRIGFPPDDGGGGLGLVTNVTVRDMLLNNVSIPIHLYQTNGALPGDAPSKLQFANLTFINVTGSTTGNTIVDLQCSSAAPCPGMVFQDINVTVPSGQTPTYECSNVVSEQGLSGCNATAQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JCF4</accession>
    <name>A0A2H3JCF4_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_109958</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467931">
        <property type="protein sequence ID" value="PCH37483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JCF4"/>
    <dbReference type="STRING" id="742152.A0A2H3JCF4"/>
    <dbReference type="OMA" id="KPCTVDW"/>
    <dbReference type="OrthoDB" id="2432613at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006078">
        <property type="term" value="P:(1-&gt;6)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042546">
        <property type="term" value="P:cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045328">
        <property type="entry name" value="Kre9/Knh1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28154">
        <property type="entry name" value="CELL WALL SYNTHESIS PROTEIN KNH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28154:SF1">
        <property type="entry name" value="CELL WALL SYNTHESIS PROTEIN KNH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013816809" evidence="2">
        <location>
            <begin position="21"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH37483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="250" mass="25392" checksum="DE81515C8F1EE969" modified="2018-01-31" version="1">MFGKLHLVVSLICLVSLVNATLYVDSPASGSTCYGGQPCIVAWVDNGEEPLLDQIGACYVGLYNGNGVLVQEIEPVNVNTVHYVQFTPDLSAGPDSSNYYVNFTSVSYMVNVTIHYTQYSPDFALASMSGSFSSPVSRDTSTLAVPSTALSPAPNSVTSVITISNSFSTTSSWSVVSSVAVTGSASGVSSSSPTSSGASSTTASSTSAVTSPSSSIVSTSAAVHSTHIGSICGSALFVMACLVACGASLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JCW9</accession>
    <name>A0A2H3JCW9_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WOLCODRAFT_107457</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467854">
        <property type="protein sequence ID" value="PCH35528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JCW9"/>
    <dbReference type="STRING" id="742152.A0A2H3JCW9"/>
    <dbReference type="OMA" id="PDKASVQ"/>
    <dbReference type="OrthoDB" id="2143914at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019185">
        <property type="term" value="C:snRNA-activating protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001006">
        <property type="term" value="F:RNA polymerase III type 3 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042795">
        <property type="term" value="P:snRNA transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042796">
        <property type="term" value="P:snRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051575">
        <property type="entry name" value="Myb-like_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
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                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
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                <person name="Copeland A."/>
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                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
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                <person name="Gaskell J."/>
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                <person name="Gorecki P."/>
                <person name="Heitman J."/>
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                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
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        <source>
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    </evidence>
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                <person name="Benoit I."/>
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        <source>
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    </evidence>
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            <dbReference type="EMBL" id="PCH40412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
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</entry>
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    <accession>A0A2H3JES8</accession>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
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                <person name="Jurgens J.A."/>
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                <person name="Kuees U."/>
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                <person name="Nagy L.G."/>
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                <person name="Ohm R.A."/>
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                <person name="Wiebenga A."/>
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                <person name="Martin F."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468053">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="221"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="331"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH40045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="407" mass="43657" checksum="4F0DB6A727B34C0B" modified="2018-01-31" version="1" fragment="single">MLRNTSISAGGSREGSVFLQSSSRLRNRKRAHAAIQKACVQYLQAITALVPQHRGPVRLVTSELTLGMSLSENGWTFASSIISVVWSFIFPSVVVWLLSFFWLWYLQKETDKVLVQLTSRILPGGGPVKHFHDSVSHEIAQLIRELHGIPLMYKLLNTAFELRRLKRVTHMLDRGMPLPPDFIEQYAAMSGTDISTTATIQSLGSNHHPRCEDYPPAENGRATSSTGTAIPLLTPSTPTSDDDSGRPDDASSDMNYDRPRAIPITSPADAAMTSAIRQRAVPITPAGSGAGGASAAQAAPTSRSSLGVASRNRFGHRDGSIDRHDLRLNSAADTPPAADTAAENVPTNLFRSASTSLTRRGSGNQGALRAMTVDGMDLSSFTNGGVPSQQAAVDRSSPTSPRSADTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JET9</accession>
    <name>A0A2H3JET9_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutathione transferase</fullName>
            <ecNumber evidence="2">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WOLCODRAFT_150747</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in the oxidative stress response and detoxification.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="2"/>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH40716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JET9"/>
    <dbReference type="STRING" id="742152.A0A2H3JET9"/>
    <dbReference type="OMA" id="SFVPWQD"/>
    <dbReference type="OrthoDB" id="422574at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03048">
        <property type="entry name" value="GST_N_Ure2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.130:FF:000016">
        <property type="entry name" value="Glutathione S-transferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF3">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR URE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01151">
        <property type="entry name" value="Main.2:_Nu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="7">
        <location>
            <begin position="5"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="8">
        <location>
            <begin position="95"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00060024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PCH40716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="228" mass="26225" checksum="FEC3C873EDB59FF7" modified="2018-01-31" version="1">MSHGKQFTFYTNVNGPNGWKIFIALEELGLTYESKYLDFSKNEHVSPEHLALNPNGRIPTIIDHANNDFVVWESNAILVYLVDKYDTSHKISVEKYEDKIVQLQWLFFQASGQGPYFGQSGWFQRYHHEKLPSAIVRYQKEILRVFGVLNSVLSKQEWLVGGKCTIADLSFIPWNRAALAWHLDDVESFNFEKDFPGLSRWHNALLSRDSARKAFAEKDALTAAGETH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JF11</accession>
    <name>A0A2H3JF11_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WOLCODRAFT_136675</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB468053">
        <property type="protein sequence ID" value="PCH40125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JF11"/>
    <dbReference type="STRING" id="742152.A0A2H3JF11"/>
    <dbReference type="OMA" id="QMTLTEP"/>
    <dbReference type="OrthoDB" id="10252354at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000165">
        <property type="term" value="P:MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06620">
        <property type="entry name" value="PKc_Byr1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000040">
        <property type="entry name" value="Dual specificity mitogen-activated protein kinase kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049613">
        <property type="entry name" value="Byr1-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050915">
        <property type="entry name" value="MAP_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47448">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE DSOR1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47448:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE STE7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="120"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="324"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="343"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PCH40125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="442" mass="48243" checksum="7982D529AB04DEAA" modified="2018-01-31" version="1">MATLAAGPVRKKRNFKALQLDVSKPPPPEPEPVPIRLAPAPGGAAGKKRPPPMTLKAPKIGTSNATVEGGDLLTVNGSTSAPPTGTASATRSSYHNTLSSTLANLDLNSETKFDLRNEDLKDLHELGQGNGGSVKKVEHVPTGTIMAKKIVLIDAKPSVRKQILRELQIMHDCSSNYIISFYGAFISDPNICICMEFMDKGSLDGIYKKIGPIDIDVVGKVALAVLEGLTYLYDVHRIIHRDIKPSNILCNSQGQIKICDFGVSGELINSIADTFVGTSTYMSPERIQGAQYTVKSDVWSLGISLIELALGRFPFADDSSDDSDLSEFEGTLSPSRPAPLPKKTKEQKEQEKKKKRRKSKGVSLQGGGMTMSILELLQHIVNEPAPRLTPEGRFPHEAEDFIDSCLLKDPDQRKTPKDLLKYPWIDHARSSTIDLEAWASTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JFB2</accession>
    <name>A0A2H3JFB2_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DRMBL-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WOLCODRAFT_91984</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467876">
        <property type="protein sequence ID" value="PCH36378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JFB2"/>
    <dbReference type="STRING" id="742152.A0A2H3JFB2"/>
    <dbReference type="OMA" id="KSGPIYC"/>
    <dbReference type="OrthoDB" id="262529at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035312">
        <property type="term" value="F:5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16273">
        <property type="entry name" value="SNM1A-1C-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12650:FF:000007">
        <property type="entry name" value="DNA cross-link repair 1A protein, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011084">
        <property type="entry name" value="DRMBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23240:SF6">
        <property type="entry name" value="DNA CROSS-LINK REPAIR 1A PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23240">
        <property type="entry name" value="DNA CROSS-LINK REPAIR PROTEIN PSO2/SNM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07522">
        <property type="entry name" value="DRMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA repair metallo-beta-lactamase" evidence="7">
        <location>
            <begin position="304"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PCH36378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="466" mass="52363" checksum="2599FA427FF4B229" modified="2018-01-31" version="1">MSSHQENEAWKEASVAEDRNFRPNKGNGGRRKAPFYKVMQGMPIAVDAFRYGTIPGVTVYFLTHAHSDHYTNLSGNWKSGPIYCSEGTANLIVHMLGVDRKWVRPLPMDTPTTVPDTGGVRVTLIEANHCPGSCLFLFEGPQTVNAGDSTFKSKFVGSPKTFRYLHCGDFRASPQHVLHPAIQGKRIDHVYLDTTYLDPKYCFPPQPQVISACAELARRFVKGESLHDAEDIAKAKKNKTMDSWLTTSEKPAVSKESKQDRVLVVIGTYSIGKERIVKAIARILQTKIYCDQRKAAILRCQADPELEALLTKDPLEGGVHLVPLGVIASDRLKEYVERFKGHFSKAVAFRPTGWTFSAPTGSDMIPSVSTIISRSQSRTFSFAQLNPMRNSSTTLQIYGVPYSEHSSFFELTCFALSLDWGKMIATVNVGSEKSRRKMATWIERWEAERKRWVNGEIVEFRAPDFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JFE5</accession>
    <name>A0A2H3JFE5_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Succinate-semialdehyde dehydrogenase</fullName>
            <ecNumber evidence="8">1.2.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WOLCODRAFT_137079</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 8">
            <text>succinate semialdehyde + NAD(+) + H2O = succinate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13217"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 8">
            <text>succinate semialdehyde + NADP(+) + H2O = succinate + NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13213"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Amino-acid degradation; 4-aminobutanoate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.16" evidence="8"/>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH40930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JFE5"/>
    <dbReference type="STRING" id="742152.A0A2H3JFE5"/>
    <dbReference type="OMA" id="IGELFCK"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="UniPathway" id="UPA00733"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004777">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036243">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07103">
        <property type="entry name" value="ALDH_F5_SSADH_GabD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000004">
        <property type="entry name" value="Succinate-semialdehyde dehydrogenase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000005">
        <property type="entry name" value="Succinate-semialdehyde dehydrogenase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050740">
        <property type="entry name" value="Aldehyde_DH_Superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010102">
        <property type="entry name" value="Succ_semiAld_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01780">
        <property type="entry name" value="SSADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353:SF5">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="9">
        <location>
            <begin position="63"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00050387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00052698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PCH40930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="528" mass="56732" checksum="073F33F048F42DB1" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JFP7</accession>
    <name>A0A2H3JFP7_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Mitochondrial carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WOLCODRAFT_139591</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467832">
        <property type="protein sequence ID" value="PCH34817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JFP7"/>
    <dbReference type="STRING" id="742152.A0A2H3JFP7"/>
    <dbReference type="OMA" id="QAFIGFC"/>
    <dbReference type="OrthoDB" id="409948at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47567">
        <property type="entry name" value="MITOCHONDRIAL SUBSTRATE/SOLUTE CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47567:SF1">
        <property type="entry name" value="NAD-DEPENDENT EPIMERASE_DEHYDRATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="5">
        <location>
            <begin position="169"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PCH34817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="349" mass="38228" checksum="3203A38B18FBEE34" modified="2018-01-31" version="1">MSDGPRPDERQPLLDNPDSVDAEGQGAAPDIPIEKKQTWWTIGWYIIISVLAGIALALFIKGFIDADDVEFDLGKALKSALGGGLSGAAAMVLQVLTLMPLRTVMNYQYRYGTTTTQAIKTLYADGGWTRYYQGLTAALIQGPVSRFGDTAANAGILALLQSNSFLKRLPALAKTVFASLAAACFRMILTPVDTVKTTMQTEGRAGLEILKARVKRYGVGTLWYGAVATAAATFVGHYPWFGTYNYLDENLPEPTTLLEKLLRQAFIGFCASVVSDTVSNSLRVVKTYRQVHQSRIGYMEAAQEVIATDGLRGLFGRGLKTRILANGLQGLMFSILWKFFLDLWNEKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JFZ4</accession>
    <name>A0A2H3JFZ4_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycosyltransferase family 32 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WOLCODRAFT_118250</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH41110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JFZ4"/>
    <dbReference type="STRING" id="742152.A0A2H3JFZ4"/>
    <dbReference type="OMA" id="GHPFMAQ"/>
    <dbReference type="OrthoDB" id="3647at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000030">
        <property type="term" value="F:mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051999">
        <property type="term" value="P:mannosyl-inositol phosphorylceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.20:FF:000005">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.17, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051706">
        <property type="entry name" value="Glycosyltransferase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32385:SF15">
        <property type="entry name" value="INOSITOL PHOSPHOCERAMIDE MANNOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32385">
        <property type="entry name" value="MANNOSYL PHOSPHORYLINOSITOL CERAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH41110.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JG27</accession>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
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                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
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                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
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                <person name="Stenlid J."/>
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                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
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                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        </location>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH34957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
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</entry>
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            <fullName evidence="1">Uncharacterized protein</fullName>
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    </organism>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
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                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
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                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
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    </dbReference>
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        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH40525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="173" mass="19783" checksum="D06F1C3060658E6C" modified="2018-01-31" version="1" fragment="single">ATATAPHRERTRRLRENLQASGDMSGRVLRVLECFKDEGLDLPLFLWALSWNPEFPELVSGGKARYARTALTHSIELPEILWRWNRPLRRHCVEVRTRAAHPIFESMASEIVKGTINAEMEKLAPALQSPQEDLSEESLLEFNWNDTASEIRAVAPMTWALLRSAAYTSRQEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JG90</accession>
    <name>A0A2H3JG90_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">adenine phosphoribosyltransferase</fullName>
            <ecNumber evidence="6">2.4.2.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WOLCODRAFT_100013</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>AMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + adenine</text>
            <dbReference type="Rhea" id="RHEA:16609"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.4.2.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenine: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.7" evidence="6"/>
    <dbReference type="EMBL" id="KB468113">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OMA" id="ITHFVYH"/>
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        <property type="reaction ID" value="UER00646"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0002055">
        <property type="term" value="F:adenine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003999">
        <property type="term" value="F:adenine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006168">
        <property type="term" value="P:adenine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000021">
        <property type="entry name" value="Adenine phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00004">
        <property type="entry name" value="Aden_phosphoribosyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005764">
        <property type="entry name" value="Ade_phspho_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050054">
        <property type="entry name" value="UPRTase/APRTase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01090">
        <property type="entry name" value="apt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002634">
        <property type="entry name" value="PRK02304.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002636">
        <property type="entry name" value="PRK02304.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32315">
        <property type="entry name" value="ADENINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32315:SF3">
        <property type="entry name" value="ADENINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="11">
        <location>
            <begin position="58"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PCH41186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="183" mass="19943" checksum="7EFC736D76ACC628" modified="2018-01-31" version="1">MADVEHLRSLLKAHPDFPKKGIVFLDIFPILRDPVAFESLITHFVYHLTSHTIPHSPSKKVDVVVALDARGFLLGPVIAMRLGAAFVPVRKKGKLPGECVTATYKKEYGSDSFEMQADAIQPGQNVVIIDDLIATGGSAKAAGQLVSQLGGKVIEYLFIIELLFLKGAQRLDAPVYSMVKTDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JGI3</accession>
    <name>A0A2H3JGI3_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_135889</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH37869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JGI3"/>
    <dbReference type="STRING" id="742152.A0A2H3JGI3"/>
    <dbReference type="OMA" id="WASNDNQ"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH37869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="312" mass="35451" checksum="14B44806CD008672" modified="2018-01-31" version="1">MNSQNETYFLPADNEEHRRLDLQHHQYKLALGGRLYPAADLVWRALCPRTDRRPAIFDVGTGSGSWALDMAREFPHCDVVGVDLVPPRIDGSIRVLPRNCRRFEIDDANLGFPHYENTFDVVHARAIDAGIRDFPAFLRELSGTLRPGGVLLLADGEQQLYDEDQRPMPLSDHGEPGFSWCHRVFFASYNAMKTRGGSIDSPSMSPTWLRAIDSLTDVGWHKIFIPMGPWHYADERERVLSELCRENCLRYISGLTPLLLSEGYLPEAVDHMCREAATELRELRTHLYTRWSFAWAVRKPTPKVPSSTSSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JGY3</accession>
    <name>A0A2H3JGY3_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_24733</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH41432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JGY3"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH41432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="57" mass="6447" checksum="17B6C1D1A5E2246E" modified="2018-01-31" version="1">MGQGAQAPSQGVQRRCSVSLRHLCSQLQHLEELAHLDVTAREKKPWDRTYGSNSTFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JH73</accession>
    <name>A0A2H3JH73_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WOLCODRAFT_134069</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467865">
        <property type="protein sequence ID" value="PCH36054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JH73"/>
    <dbReference type="STRING" id="742152.A0A2H3JH73"/>
    <dbReference type="OMA" id="HGFYKYM"/>
    <dbReference type="OrthoDB" id="414781at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034067">
        <property type="term" value="P:protein localization to Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45909">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45909:SF1">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="24"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="133"/>
            <end position="136"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PCH36054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="235" mass="26756" checksum="F466FD7F8E209176" modified="2018-01-31" version="1">MYHLLKGFYEYFTRKEEFSVIILGLDGAGKTTLLEKIKTLYNDTPGLPPNKIAPTVGQNMGKITLPSTILQFWDLGGQRGIRSIWHRYYDDCHAVVFVIDAQDRERLGEGWEVFDSVLSSPKILGVPLLLLANKQDSPQSLSVEEIRNDYEEWYRSKQDAARRSYGDEVELEHRRDRIASLDVMGISALEGCAYAFPVCAHWLTSGPSTGVRAAVDWLFIRVQNSRRRDELDSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JHD9</accession>
    <name>A0A2H3JHD9_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_137108</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH40975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JHD9"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH40975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="81" mass="9258" checksum="ACC9EAEBC2E873F2" modified="2018-01-31" version="1">MAWHRARVEQRARAAETQTSHWPNLVGTDDVAIVNGRSCIIRRRTRRFHRSSEAELARPMISTDRCRSPGTASAGSRRWIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JI82</accession>
    <name>A0A2H3JI82_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WOLCODRAFT_140862</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467931">
        <property type="protein sequence ID" value="PCH37438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JI82"/>
    <dbReference type="STRING" id="742152.A0A2H3JI82"/>
    <dbReference type="OMA" id="ETGWRWM"/>
    <dbReference type="OrthoDB" id="6339427at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005366">
        <property type="term" value="F:myo-inositol:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904679">
        <property type="term" value="P:myo-inositol import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000073">
        <property type="entry name" value="MFS myo-inositol transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF12">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="303"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="339"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="369"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="410"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="444"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="396" mass="43524" checksum="FFDA1CA46D2CE412" modified="2018-01-31" version="1">MDSRQLSAHQNRGDGLEHHCAGVVSPVLKDSESLARHSLTNSALLEGATLHEVEANCASGYPQDAIPTTKTAELPSKCPAHVLSLSGVGATRFLLGSSLSAALGLSHPMALSYTSSPPSKYRLQLRPARSRRNNTPVTTESSLNDLCRGTDCSPILPRKSPWTHIFTVQNPPFGASIEFVEISRSSTSLPIILRLPPLSDIQPLPLLRQGSKPALPRGLPTNQLYVPRRWNWNLPRFPAEIIALIIDALGDLLVSCTTYQSGSCFKSLRNALRHCALTCSFCCRISQRNLVRRVALCNPRQLEAFKTLIRKKGNLARHVEAIVVGYPRRICTIAATTVLESLPAPLAEKVQKLEITYERSYFSFFGAPQGGFWQYLHKFSSVSKLHLSDIRVGSRG</sequence>
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            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Yadav J.S."/>
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                <person name="Benoit I."/>
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                <person name="Glotzer D."/>
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                <person name="Kallen N."/>
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                <person name="Kumar T.K.A."/>
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                <person name="Patyshakuliyeva A."/>
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                <person name="Stenlid J."/>
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                <person name="Wiebenga A."/>
                <person name="Young D."/>
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                <person name="Eastwood D.C."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD-104</strain>
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    </reference>
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    <dbReference type="OrthoDB" id="429813at2759"/>
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    </dbReference>
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            <end position="360"/>
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    </feature>
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            <end position="948"/>
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    </feature>
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            <begin position="1"/>
            <end position="26"/>
        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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    </evidence>
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        <source>
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            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF07993"/>
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        <source>
            <dbReference type="EMBL" id="PCH42382.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="1089" mass="120058" checksum="5A2421CD436DFA9C" modified="2018-01-31" version="1"> </sequence>
</entry>
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    <accession>A0A2H3JK63</accession>
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            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Blanchette R.A."/>
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                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
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                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
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                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
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                <person name="Martin R."/>
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                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
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                <person name="Stenlid J."/>
                <person name="Sun H."/>
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                <person name="Syed K."/>
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                <person name="Wiebenga A."/>
                <person name="Young D."/>
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                <person name="Martin F."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JK63"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH41935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="84" mass="8964" checksum="CD340314F63D9C59" modified="2018-01-31" version="1">MRDASAMQALGSNATAWVRGALVHAGAGRWASQNQRTPPHQEGPLEHTQEQDHLVCEAGAAFTPCNPDAVSARTAKTLDNQQTE</sequence>
</entry>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
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                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
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                <person name="Kallen N."/>
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                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
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                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH37274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="101" mass="11135" checksum="DF32EFBA42A77272" modified="2018-01-31" version="1">MVRRHLKPTPPPARCHIDGVPLERRLNKPHTTAYPNRSPTPPLRRTRLARMERRLPKTVHYDHDTVLPSCVTTSATAASEPLAHALGTQAPTVNGHTGVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JKX1</accession>
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        <lineage>
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            <taxon>Phaeolaceae</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
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                <person name="St John F."/>
                <person name="Stenlid J."/>
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                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JKX1"/>
    <dbReference type="Proteomes" id="UP000218811">
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    </dbReference>
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        </location>
    </feature>
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            <end position="231"/>
        </location>
    </feature>
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        <location>
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            <end position="29"/>
        </location>
    </feature>
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            <end position="220"/>
        </location>
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            <begin position="222"/>
            <end position="231"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="231" mass="25198" checksum="2F53133B014DEF2B" modified="2018-01-31" version="1">MPYPAGDAAREEIDFFDYDDDGESGEESNESGFVQEDLDEGGALAMSILQDEHASVNELQEIQFLFAYDSHFTDKGKQTGIKWQSDFELYRCKITLMESEQQNSLFCFYNEIVFPGISLGINETVQTQGDGSQPDEDDFDSELHALDQRNAENPTDVNLSIPEATIPAAENFLQTVPTASSANGSEQALEAPALQSTGQKAKRTRKPNSAHTVESANTHKASGGGCAKRSG</sequence>
</entry>
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    <name>A0A2H3JL21_WOLCO</name>
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            <fullName evidence="1">DCUN1 domain-containing protein</fullName>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
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                <person name="Barry K."/>
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                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
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                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
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                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
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                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
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                <person name="Martin R."/>
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                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        </location>
    </feature>
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        </location>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="70" mass="7673" checksum="84EE5AFF3BB88902" modified="2018-01-31" version="1" fragment="single">YSAAHAGSLFDAYADSDEPTVIGPEGFERLCSDMDISMEGALPLILAWQMSSSEMAKISKVEWEKNTTEL</sequence>
</entry>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
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                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
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                <person name="Ferreira P."/>
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                <person name="Foster B."/>
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                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
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                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
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                <person name="Schmutz J."/>
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                <person name="Stenlid J."/>
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                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
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                <person name="Eastwood D.C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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        <location>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH36747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="361" mass="39711" checksum="5D91ED3E03A3900C" modified="2018-01-31" version="1">MSALVRHDRERGGTVHASADSDQARILGKDKDRHRSNSQSGTSGMPPTPKATERPTSQVEQRRRRFNKRATPSTDRAHKLSSRARSQHAARQRVGRGADHTNTPLGPATWSHHTPTASHSNREKAPPLRCPDATGTPHRHQQQQHQRTDKVRHSPRPSTVGGHTGQKASTPIIPPGRRCISQRQTQPLTLPPPRQAMPRYGDRRTLKDRRPAPSSKGEAPALAGTSKKITKDSGAPLNAQRDKVQRHPSTVSPPVTAKPSGCQPARRPGPLGPRDTEPTIKAISINKQLWKERQGAWAAHPRTRQYPRRHNSSDAQSSRTGPDSQEHRPTDVKPEQQGPLAGATPIHHRPQASPSIKISGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
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    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_132585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468135">
        <property type="protein sequence ID" value="PCH42966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JL84"/>
    <dbReference type="STRING" id="742152.A0A2H3JL84"/>
    <dbReference type="OMA" id="CWTIHRP"/>
    <dbReference type="OrthoDB" id="3362250at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH42966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="349" mass="38338" checksum="6A0211AEC5AF9465" modified="2018-01-31" version="1">MSQPTHPRDVHEYSRFSVETSDVLSDMRVNVMAEGAERVIWYKERFLADEEIIEHLVENATSTILWSIHRPKRGWYIRLCSPSFPTGTFIPLIPLPQTSPFYADAALSFACRTNPPSYSLSNSPDQRFTITRDSIDSDVTVTDSPRNSAVHSYPPTPPRQTPAVIVSPPSPRSINAKLEEVEIVVAASSSSAPEPPPAQRPPRTPLAPITHFLLTPHSTPHVPQPTQSVSIFARVMSALKNNAPSHAYSFTLSPIPSPNPSPSSSAARDGSIPAIPTIPADPTPTTPVPLLTFHDRTPVWTVRSNSGTLEIDKTQVRTLGVDISFYIAVALTYLEFLSERESYLAALND</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JNH0</accession>
    <name>A0A2H3JNH0_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_138176</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468135">
        <property type="protein sequence ID" value="PCH43045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JNH0"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH43045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="67" mass="7395" checksum="6EEEF56826D17B73" modified="2018-01-31" version="1">MIRRRLQSQESSGCSPRGCWGHAHVARVTRFVGCMLNSNAVLDFIVDGTGKPLDYQDQAARANDEDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JNK2</accession>
    <name>A0A2H3JNK2_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Probable electron transfer flavoprotein subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WOLCODRAFT_136833</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 7">The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </cofactor>
        <text evidence="7">Binds 1 AMP per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="7">Binds 1 FAD per dimer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the ETF beta-subunit/FixA family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468053">
        <property type="protein sequence ID" value="PCH40379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JNK2"/>
    <dbReference type="STRING" id="742152.A0A2H3JNK2"/>
    <dbReference type="OMA" id="EINQPRI"/>
    <dbReference type="OrthoDB" id="276685at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009063">
        <property type="term" value="P:amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01714">
        <property type="entry name" value="ETF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000011">
        <property type="entry name" value="Electron transfer flavoprotein subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000049">
        <property type="entry name" value="ET-Flavoprotein_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012255">
        <property type="entry name" value="ETF_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033948">
        <property type="entry name" value="ETF_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21294">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN BETA-SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21294:SF8">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000090">
        <property type="entry name" value="Beta-ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01065">
        <property type="entry name" value="ETF_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Electron transfer flavoprotein alpha/beta-subunit N-terminal" evidence="8">
        <location>
            <begin position="30"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00070315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PCH40379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="270" mass="29335" checksum="3265806E64791BF3" modified="2018-01-31" version="1">MRPSAVRLLNILVPIKRTVDYAVKIRVNPDQKGIDLNVKHSMNPFDEIAVEEAVRLRERLKDEVKSIKVVTIGPPKSAETLRTALAMGADSGIHVEIPDSAPSPEPLGVAKALRAIIQREKEQGGVDLVIMGKQAIDDDAGQTGQMLAGLMDWPQATFASKVELDVTKNGANVTREIDGGLEELRCRLPLVVTTDLRLNEPRYASLPNIMKAKKKPIEKLTATDLQVDLTPRLETLKVTEPPKRQGGGKVANVDELIAKLKEAGIGPVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JQ41</accession>
    <name>A0A2H3JQ41_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">UPF0029-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WOLCODRAFT_71031</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IMPACT family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH40929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JQ41"/>
    <dbReference type="STRING" id="742152.A0A2H3JQ41"/>
    <dbReference type="OMA" id="INAWRCR"/>
    <dbReference type="OrthoDB" id="69641at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140469">
        <property type="term" value="P:GCN2-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006446">
        <property type="term" value="P:regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.30">
        <property type="entry name" value="Impact, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023582">
        <property type="entry name" value="Impact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001498">
        <property type="entry name" value="Impact_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036956">
        <property type="entry name" value="Impact_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16301">
        <property type="entry name" value="IMPACT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16301:SF24">
        <property type="entry name" value="RWD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01205">
        <property type="entry name" value="Impact_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00591">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0346">Stress response</keyword>
    <keyword evidence="5" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="RWD" evidence="8">
        <location>
            <begin position="31"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="183"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="342"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="54"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="183"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PCH40929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="362" mass="39197" checksum="4C40ECEFA879EF77" modified="2018-01-31" version="1">MSSRTPSPVFESLESLIAHLSADPEREPIAAELGVLQSIYGDDAVRLWRRAPSSDGTRSDQGSTSANAGERGTIRYEVTVSISPLSEPDTAHPTTLLISLPSTYPASSPPQLQLLSRYIGPFGVDAGLFGAVLRTFISQNGVEWTEGCVCVFDGIEWVRERCAEWLGDKMSAVKVGELAREDERPVVETKREAQAEQASAPEPDPEPLDLPEGVAFTVAEPIVDRKSVFIGRACRITDPAQVPLILAHLMSDRRIARAAHPIINAWRCRVGSNLHQDNDDDGETAAGGRLAHLLQILEVENVLVVVTRYFGGIHLGPDRFKHINQAARNALELGGFLDVPSTDGHSGGRKKGKMQASAGSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2024-01-24" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JR26</accession>
    <name>A0A2H3JR26_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_29774</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467963">
        <property type="protein sequence ID" value="PCH39124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JR26"/>
    <dbReference type="STRING" id="742152.A0A2H3JR26"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH39124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="147" mass="15512" checksum="4E6803613F0A41DA" modified="2018-01-31" version="1">MSLLTDEDRLSLITYTTTTITASDGRQQTHTPFKVVAPERRIATPSTRAGSSHMVVPGQPMSALHSSSSALSLTTNGTPVSMLSPFKKMPSSSVPHLRISSLGNMRPLGLPSIPHIQSAAMNVSLSSPHNTPPLHTGIRIHGTDAGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JR60</accession>
    <name>A0A2H3JR60_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acetyl-CoA synthetase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WOLCODRAFT_102030</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468124">
        <property type="protein sequence ID" value="PCH42383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="742152.A0A2H3JR60"/>
    <dbReference type="OMA" id="VGREQAM"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="O-FucT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051414">
        <property type="entry name" value="Adenylate-forming_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439:SF2">
        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439">
        <property type="entry name" value="PHENYLACETATE-COENZYME A LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="AMP-binding_C_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="3"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Polyketide synthase-like phosphopantetheine-binding" evidence="4">
        <location>
            <begin position="590"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="domain" description="Polyketide synthase-like phosphopantetheine-binding" evidence="4">
        <location>
            <begin position="1745"/>
            <end position="1820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="2344"/>
            <end position="2367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PCH42383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="2889" mass="318237" checksum="9DD7301FCA8497CE" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JRG5</accession>
    <name>A0A2H3JRG5_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_23461</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH38597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OMA" id="VINMATW"/>
    <dbReference type="OrthoDB" id="3242409at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="2">
        <location>
            <begin position="25"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH38597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="219" mass="24448" checksum="E4726BF00801865B" modified="2018-01-31" version="1" fragment="single">MSLSSTNATEVYDIYALRSALTAEYFPISYSAMIFYECIITLNDEISYVWKYRRTATTLLLLSNRCFLIMSALIQLSLPLPDNKFCLVLNILQFIVGAFGYLILAVFSALRIYAISSGKWFYALVILVLGLSAPGANLYFGITVIDVTFTKVVNVNLCYYSFAGNGNDNFIMSIAVLTACIVVSESTVAIATWIYTSHWRKDSKQLGSRALLVTRTFVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JRN9</accession>
    <name>A0A2H3JRN9_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Galactose mutarotase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_92588</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467987">
        <property type="protein sequence ID" value="PCH39334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JRN9"/>
    <dbReference type="STRING" id="742152.A0A2H3JRN9"/>
    <dbReference type="OMA" id="HWGFNLE"/>
    <dbReference type="OrthoDB" id="274691at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004034">
        <property type="term" value="F:aldose 1-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose, Leloir pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10091">
        <property type="entry name" value="ALDOSE-1-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10091:SF0">
        <property type="entry name" value="GALACTOSE MUTAROTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH39334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="434" mass="46531" checksum="90C002036112F95E" modified="2018-01-31" version="1">MASTLDPAFSPLLLTQASLNPCLALEVLPMGITLHRLFVQADGKTHDILIGPESPAGHLTQKYTNTIIGRYANRVPVPPAGTLPIARNGASAEIAPRANERPTVSLHGGLTGWDLTPWTPVLDTAVEADPAARVTLFTAAELARVQAAIPAGAYAFFVRESPDGEEGFPGRLRVEVLVALLDARGRADGARDGEWHLGSVLLVYRAKLLDGAVTAVNMTQHWGFNLDASLQEGVSVRDHSLTIKADHTLAYLPDANSAGALAPVAGTHHAHAEKTTRTIGERFPENGYDEFYVFAPRPDAPVLPPPRVSEAELGPEADLLAPALEARDPVVELAGAKSGLRVDFTTNQSGVQFYSNNFVDPKKTARKKIHGGSGEKGDGYEAGSAAFLEFHEPLAAWMHPDTLGPSRHDTLLAAGEVYNSFVRMDVWYRSQEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JRP9</accession>
    <name>A0A2H3JRP9_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Serine hydroxymethyltransferase</fullName>
            <ecNumber evidence="9">2.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WOLCODRAFT_154869</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Interconversion of serine and glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:15481"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 8 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the SHMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="9"/>
    <dbReference type="EMBL" id="KB468168">
        <property type="protein sequence ID" value="PCH44840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JRP9"/>
    <dbReference type="STRING" id="742152.A0A2H3JRP9"/>
    <dbReference type="OMA" id="VTNRNAI"/>
    <dbReference type="OrthoDB" id="10265628at2759"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000050">
        <property type="entry name" value="Serine hydroxymethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00051">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049943">
        <property type="entry name" value="Ser_HO-MeTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019798">
        <property type="entry name" value="Ser_HO-MeTrfase_PLP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000586">
        <property type="entry name" value="PRK00011.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680:SF35">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000412">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00096">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5 9" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="7 8 9" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Serine hydroxymethyltransferase-like" evidence="10">
        <location>
            <begin position="15"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000412-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PCH44840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="478" mass="52093" checksum="DECBF02E1F7681D1" modified="2018-01-31" version="1">MSAIPAFNKALYAPLAEVDPEVQNIIDKETWRQYSGLELIASENLTSRATMEANGSILTNKYSEGLPNARYYGGNEWIDELEVLCQKRALQAFHLDPAKWGVNVQPYSGSTANFAALTALLQPQDRLMGLGLPDGGHLTHGYYTAKKKMTASSIYFQSLPYGLDPATQLIDYVALKSQAKLFKPQLLICGASAYPRDWDYAALRAIADEHGAFLMADIAHTSGLVAAGELADPFAYCDVVTTTTHKTLRGPRAGLIFFRKDSEKAKGLEKRVNDAVFPACQGGPHNNTIAGIATALLQASQPEWKAYAKQVIANARTLGEELVAQGYKLQTQGTDNHLVLWDLRPLGLTGSKLEKLCDLVGITINKNAVSGDASAQVPGGIRLGTSALTSRNMTEDDIRVVAGFLHRAVQIALVLQREAGSKLLKDFVRVAATVEEGKEGARLVRELRREVRVFARRWPVPGVDFASIKRPAGIEEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JRU6</accession>
    <name>A0A2H3JRU6_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Geranylgeranyl pyrophosphate synthetase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_150530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468053">
        <property type="protein sequence ID" value="PCH40488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JRU6"/>
    <dbReference type="STRING" id="742152.A0A2H3JRU6"/>
    <dbReference type="OMA" id="PELLCCY"/>
    <dbReference type="OrthoDB" id="420564at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35179">
        <property type="entry name" value="PROTEIN CBG02620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35179:SF2">
        <property type="entry name" value="START DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH40488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="384" mass="43743" checksum="B81EFB93CAA2E102" modified="2018-01-31" version="1">MRVGRGLRKAPVATLPLPTLLPESLTSERIQPRNAQLLGSYNWLEARKATMLVPGVPPRWRDPEGPYQILRDRGVYCVEQNAHRLPHSPLLPAMYAVDITSKLTEQKVDWSTVDFVIDRNTLRDFLQWIAKQDTAKFRIDTQLAGERTVLCTRRTVHNKVKIDSMRDGSYKHSFARASAIRDPRFAEEKSASHHRIIKYDYDGLNMVVIYEAGAYTRWPGVRNMIMPDSSPSATAHKSQGNKVKGHLSVIFGGVLVSEDYIAELACCATDTTKELVWKDRYPHMFLSQTPTLLCGVHSSGTVKFVIRRALDDPDMQKADAELQSDFKKLRLLLSDIQRMVIQHGKQGRLSFAYEKGNLRVYDRIDQTNCLPSEVMARFDSRDKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JSG9</accession>
    <name>A0A2H3JSG9_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_165603</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
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                <person name="Barry K."/>
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                <person name="Martinez A.T."/>
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    </evidence>
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    <sequence length="282" mass="31723" checksum="114B5929D2D30618" modified="2018-01-31" version="1">MSRGDREASSGILKHSMRDNYAELGVEEYYRRVGATYRNPHFPGVRSCLFRWMNAWWECERSNSPSNGFTVFDMACGSGEATLAVLEWWHLGRRAFDESQLPNSSDPGLTIQQAAILKRNANKFVRPPPIVSESPRPTILAADPFTAEAYRARTTLGCSSLSFSEIAEGGLSDLLSSSQGENNSGDETADIIPDTPTIDMVICSFALHLIETPSELFALLWELSMKCKWLVIVAPHKKPDIKDGWGWSKWNVETWSECPMTESKGELLQERVHCRIYRSLNL</sequence>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Regulates mitochondrial small subunit maturation by controlling 15S rRNA 5'-end processing. Localizes to the 5' precursor of the 15S rRNA in a position that is subsequently occupied by mS47 in the mature yeast mtSSU. Uses structure and sequence-specific RNA recognition, binding to a single-stranded region of the precursor and specifically recognizing bases -6 to -1. The exchange of Ccm1 for mS47 is coupled to the irreversible removal of precursor rRNA that is accompanied by conformational changes of the mitoribosomal proteins uS5m and mS26. These conformational changes signal completion of 5'-end rRNA processing through protection of the mature 5'-end of the 15S rRNA and stabilization of mS47. The removal of the 5' precursor together with the dissociation of Ccm1 may be catalyzed by the 5'-3' exoribonuclease Pet127. Involved in the specific removal of group I introns in mitochondrial encoded transcripts.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Binds to mitochondrial small subunit 15S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH40864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JVX0"/>
    <dbReference type="STRING" id="742152.A0A2H3JVX0"/>
    <dbReference type="OMA" id="DFFTPHP"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447">
        <property type="entry name" value="OS03G0856100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447:SF17">
        <property type="entry name" value="OS12G0638900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="5">
        <location>
            <begin position="561"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="5">
        <location>
            <begin position="705"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="5">
        <location>
            <begin position="746"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="5">
        <location>
            <begin position="832"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="42"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1005"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PCH40864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1169" mass="131488" checksum="4356F6AB95375A45" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JXD6</accession>
    <name>A0A2H3JXD6_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 14">DNA replication licensing factor MCM6</fullName>
            <ecNumber evidence="3 14">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">WOLCODRAFT_99376</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="14">Component of the MCM2-7 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3 14"/>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH40837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JXD6"/>
    <dbReference type="STRING" id="742152.A0A2H3JXD6"/>
    <dbReference type="OMA" id="RHQQTDK"/>
    <dbReference type="OrthoDB" id="1744952at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097373">
        <property type="term" value="C:MCM core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990518">
        <property type="term" value="F:single-stranded 3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902969">
        <property type="term" value="P:mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17757">
        <property type="entry name" value="MCM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.870:FF:000002">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000003">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000115">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.870">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008049">
        <property type="entry name" value="MCM6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041024">
        <property type="entry name" value="Mcm6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF43">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18263">
        <property type="entry name" value="WHD_MCM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01662">
        <property type="entry name" value="MCMPROTEIN6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 14" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 14" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="16">
        <location>
            <begin position="450"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="810"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="11"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="824"/>
            <end position="841"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00073495"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU368064"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH40837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="980" mass="108107" checksum="E4DC46F56B440A8F" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JXH7</accession>
    <name>A0A2H3JXH7_WOLCO</name>
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            <fullName evidence="4">CASP C-terminal domain-containing protein</fullName>
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        <name evidence="5" type="ORF">WOLCODRAFT_18462</name>
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        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
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        <lineage>
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        </lineage>
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    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
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                <person name="Rokas A."/>
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                <person name="Sabat G."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5 6">MD-104</strain>
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    </dbReference>
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            <begin position="285"/>
            <end position="367"/>
        </location>
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        </location>
    </feature>
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        </location>
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            <begin position="217"/>
            <end position="251"/>
        </location>
    </feature>
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        <location>
            <begin position="287"/>
            <end position="314"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
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</entry>
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    <accession>A0A2H3JXW7</accession>
    <name>A0A2H3JXW7_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FAD/NAD(P)-binding domain-containing protein</fullName>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
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                <person name="Ferreira P."/>
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                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
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                <person name="Heitman J."/>
                <person name="Hesse C."/>
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                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
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        <property type="protein sequence ID" value="PCH42698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF147">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G01950)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="7">
        <location>
            <begin position="11"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="358"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="358"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="PCH42698.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JYN0</accession>
    <name>A0A2H3JYN0_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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        <lineage>
            <taxon>Eukaryota</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468124">
        <property type="protein sequence ID" value="PCH41854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JYN0"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH41854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="235" mass="26727" checksum="81E754F7A5A353E8" modified="2018-01-31" version="1">MQNSPKPVDYEQDAEEIKSTKDKGKGKEKKSGAFWKTLDQQSEEDEDAEGEDEIMEDEDETMRDQEEEEQEDEEQEQDEQEDPVQEWMDKIKTRSHNSSQDVEMDDEVSRPGPSTFQQSSKVASELRRSRRVADRKVREVGQGGSARVCPISASSVMLQNPQPGDDEGDYRRYCSQVGDDHDQLLQAIRDMSGLLEQVIHKVDGLEKSIHQLSVGNLGMQTQMEALQQPHPSCLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JZ43</accession>
    <name>A0A2H3JZ43_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_72148</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468124">
        <property type="protein sequence ID" value="PCH42004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JZ43"/>
    <dbReference type="OMA" id="CIEFIAN"/>
    <dbReference type="OrthoDB" id="2804352at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF17">
        <property type="entry name" value="FUNGAL STAND N-TERMINAL GOODBYE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="2">
        <location>
            <begin position="228"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH42004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="711" mass="79309" checksum="93E5852A264EC79B" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JZD2</accession>
    <name>A0A2H3JZD2_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WOLCODRAFT_18819</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB468157">
        <property type="protein sequence ID" value="PCH44269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JZD2"/>
    <dbReference type="STRING" id="742152.A0A2H3JZD2"/>
    <dbReference type="OMA" id="NECNTHR"/>
    <dbReference type="OrthoDB" id="6333297at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050888">
        <property type="entry name" value="ZnF_C2H2-type_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24406">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR CTCFL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="408"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="372"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="380"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PCH44269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="467" mass="51255" checksum="F014A4E29E9287E3" modified="2018-01-31" version="1">MRQQSVIQYYSRVETMSGGTNISQRGSKIQGASTTHAAANLVHINGAPFVFSCTVCNVSFWTDESRQQHYLTSLSHPTCNLCIKGFQDQVDLESHNSQVHGLTKVKCNPCGKLFTPAELQQHFNASPAHPNCIHTADAHPDSRCSVCAQLFRDKAALQHHFDGSSMHPSCAICEVGFLDDAACDEHMVIAHPPRMPEAPPAPPMIPLEEEVYICSSAASVHSEDVTLATPSSIASELRSRHNSHAPRKCAQPINDVRALGAELRRKEGAIVYVQQPNTFCYTQDGVDDVPSGRKTPQMPSISLQNGQLLMESTVRPSSVLSVRPTTPPPQDVTRDLEPAAQAPILTSASVWSQIPLRNSELAPLERPSIVSTEAEDTAQEDATPNATTQTPQSMPTTLPPSKAISWHCRICLRDPCDQPTATMCGHLFCHRCIIEQLSENLQCPVCKKVRLEDKISSSRYHNNEYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JZQ7</accession>
    <name>A0A2H3JZQ7_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Terpene cyclase/mutase family member</fullName>
            <ecNumber evidence="7">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WOLCODRAFT_138974</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
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            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF13249"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH44389.1"/>
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    </evidence>
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        <source>
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    </evidence>
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</entry>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
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                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
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                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
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                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
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                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="PCH44419.1"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="407"/>
        </location>
    </feature>
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        <location>
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        </location>
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        </location>
    </feature>
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        <location>
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            <end position="52"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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        </location>
    </feature>
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        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH44419.1"/>
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        </source>
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</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
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                <person name="Coutinho P.M."/>
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                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
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                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
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                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
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                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
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                <person name="Nagy L.G."/>
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                <person name="Ohm R.A."/>
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                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD-104</strain>
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            <name>pyridoxal 5'-phosphate</name>
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        </cofactor>
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        <text evidence="2">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.</text>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
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                <person name="Larrondo L.F."/>
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                <person name="Ling A."/>
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                <person name="Tsang A."/>
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            <dbReference type="DOI" id="10.1126/science.1221748"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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</entry>
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            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Barry K."/>
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                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
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                <person name="Benoit I."/>
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                <person name="Kallen N."/>
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                <person name="Nagy L.G."/>
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                <person name="Ohm R.A."/>
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                <person name="Sabat G."/>
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                <person name="Stenlid J."/>
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            <dbReference type="DOI" id="10.1126/science.1221748"/>
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            <strain evidence="3 4">MD-104</strain>
        </source>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
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    </evidence>
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        </source>
    </evidence>
    <sequence length="249" mass="26622" checksum="E876CF30B67D122B" modified="2018-01-31" version="1">MSYASVAAQNAPPSSQQPRPDPALLTTEPPSADNIADDAAKVNVVSADFRANPATVTSESTVPPESASPPGSPSRKGRARTYLHEAEAEGFYLWGTAKHYLLRPAVAGGLLGLVNVGLLGSAGYALYTRPHLRRDARALASAAATALVVLGGESYAAEKYRETPRGRAEEERARSEGAALYRHARECILRPGVLGGLLGVLNTGIISAIGYFAYTEWDRPRWDRRTVSAISVGLIALWSGEGYLAERYR</sequence>
</entry>
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    <name>A0A2H3K5D5_WOLCO</name>
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        <recommendedName>
            <fullName evidence="6">NADH-ubiquinone oxidoreductase 21 kDa subunit</fullName>
        </recommendedName>
    </protein>
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        <name evidence="4" type="ORF">WOLCODRAFT_26632</name>
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    <organism evidence="4 5">
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Riley R."/>
                <person name="Barry K."/>
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                <person name="Henrissat B."/>
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                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468157">
        <property type="protein sequence ID" value="PCH44264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K5D5"/>
    <dbReference type="STRING" id="742152.A0A2H3K5D5"/>
    <dbReference type="OMA" id="TVPWFNF"/>
    <dbReference type="OrthoDB" id="196140at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053229">
        <property type="entry name" value="NADH-Q_oxidrdct_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024549">
        <property type="entry name" value="NADH-UbQ_OxRdtase_su21_C_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019721">
        <property type="entry name" value="NADH-UbQ_OxRdtase_su21_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34062:SF1">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 21KDA SUBUNIT N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34062">
        <property type="entry name" value="OXIDOREDUCTASE 21 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G04750)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10785">
        <property type="entry name" value="NADH-u_ox-rdase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12853">
        <property type="entry name" value="NADH_u_ox_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="NADH-ubiquinone oxidoreductase 21kDa subunit N-terminal" evidence="2">
        <location>
            <begin position="8"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="NADH-ubiquinone oxidoreductase 21kDa subunit C-terminal fungi" evidence="3">
        <location>
            <begin position="99"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PCH44264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="165" mass="18990" checksum="DF3746DAE8A35D73" modified="2018-01-31" version="1">MPEKVIDTPYPLIDADPHAARVVRYMRPSDYGVWAAATGAFPAALYFWEMADPTKFRMRTHLRLGGVLGFVGGFLLAYQRSSFRFWGWSENKREEERDRAEMTERLRQGLPLYGETDQPEWVQGAAYRNSAFSQLKFSIVPMFNLVNHLHHGVDPEKYKSQNGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K5G1</accession>
    <name>A0A2H3K5G1_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Holocytochrome c-type synthase</fullName>
            <ecNumber evidence="10">4.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WOLCODRAFT_77296</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>holo-[cytochrome c] = apo-[cytochrome c] + heme b</text>
            <dbReference type="Rhea" id="RHEA:22648"/>
            <dbReference type="Rhea" id="RHEA-COMP:10725"/>
            <dbReference type="Rhea" id="RHEA-COMP:10726"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="ChEBI" id="CHEBI:83739"/>
            <dbReference type="EC" id="4.4.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the cytochrome c-type heme lyase family.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.17" evidence="10"/>
    <dbReference type="EMBL" id="KB468157">
        <property type="protein sequence ID" value="PCH44294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K5G1"/>
    <dbReference type="STRING" id="742152.A0A2H3K5G1"/>
    <dbReference type="OMA" id="KARFWLF"/>
    <dbReference type="OrthoDB" id="4243at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004408">
        <property type="term" value="F:holocytochrome-c synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000511">
        <property type="entry name" value="Holocyt_c/c1_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12743">
        <property type="entry name" value="CYTOCHROME C1 HEME LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12743:SF3">
        <property type="entry name" value="HOLOCYTOCHROME-C SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01265">
        <property type="entry name" value="Cyto_heme_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00821">
        <property type="entry name" value="CYTO_HEME_LYASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00822">
        <property type="entry name" value="CYTO_HEME_LYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0349">Heme</keyword>
    <keyword evidence="6 10" id="KW-0408">Iron</keyword>
    <keyword evidence="9 10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PCH44294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="200" mass="22946" checksum="8A5E9AB998C9C05A" modified="2018-01-31" version="1">MPTLSQAPAANQSVALPTAREESTIPRDEAANWEYPSPQQFYNALVRKGWETPEEHVETMVQIHNFLNEQAWQEILKWERKENPTEDPHLSRFKGRPGELSPKARFWLFAGWLLPSRFNTEPPFDRHDWVVRRKSTGEEVRYVIDYYSAPPEPDGSPVFSLDVRPALDNFGSIKQRIVAATEDVWSSVRDNGQAGVARNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3ITE3</accession>
    <name>A0A2H3ITE3_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">L-lactate dehydrogenase (cytochrome)</fullName>
            <ecNumber evidence="17">1.1.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Cytochrome b2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Flavocytochrome b2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">L-lactate ferricytochrome c oxidoreductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">WOLCODRAFT_134829</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26 27">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(S)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:19909"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16651"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.1.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:19910"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="22">Belongs to the cytochrome b5 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="15">In the C-terminal section; belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="16">In the N-terminal section; belongs to the cytochrome b5 family.</text>
    </comment>
    <dbReference type="EC" id="1.1.2.3" evidence="17"/>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH32971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3ITE3"/>
    <dbReference type="STRING" id="742152.A0A2H3ITE3"/>
    <dbReference type="OMA" id="FHAKDVF"/>
    <dbReference type="OrthoDB" id="1925334at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004460">
        <property type="term" value="F:L-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006089">
        <property type="term" value="P:lactate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02922">
        <property type="entry name" value="FCB2_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000009">
        <property type="entry name" value="Cytochrome b2, mitochondrial, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000062">
        <property type="entry name" value="Cytochrome b2, mitochondrial, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008259">
        <property type="entry name" value="FMN_hydac_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037458">
        <property type="entry name" value="L-MDH/L-LDH_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF101">
        <property type="entry name" value="L-LACTATE DEHYDROGENASE (CYTOCHROME B2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00557">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0288">FMN</keyword>
    <keyword evidence="6 22" id="KW-0349">Heme</keyword>
    <keyword evidence="12 22" id="KW-0408">Iron</keyword>
    <keyword evidence="9 22" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="24">
        <location>
            <begin position="2"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="25">
        <location>
            <begin position="110"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="299"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="23">
        <location>
            <begin position="307"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00052399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00061137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00061589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00066458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00068515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00075949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00078774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00078938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="PCH32971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="500" mass="55010" checksum="00D16BE88F5BF86D" modified="2018-01-31" version="1">MSRTWSLDEVSKHNTTKSCWVIIKNKVYDVTEFLPEHPGGSSIILKYAGRDATAAYEPIHPPDALHKNLPAQKHLGTLDTQGAETLKKANEQRRKTKDEIRVEQAQKKKPPVSRILSVKEMEDVALRVLSFKAAAYYSTGADDEITLSENARAFSRFFFRPRVLRPISSVDPSTTILGFQSSLPIFVSGTGLAKLGHPLGEANITRGCGRTALIQMVSTYASLSASEVAAARLSPAQPLFFQLYKHADDARAAALLREIETLGYNAVFLTVDAPVAGNRERDVRAPFELEAQEREIEAEARGVAETEGLEGEPEMPDQGVDEDDGGTATPFLNITDHNMTFEKTIPWLRRNTKLPIVLKGIQCVEDAVLAAEAGVDGILLSNHGGRQLEYSPPPLEVLYQLRQQRPDVFDKLEVYVDGGVRRGTDVLKALCLGAKAVGLGRAFLYAQSAYGEAGVVQVARIMQREIVLGMRLLGVTSVSELRPELVERIDWQPSLPRAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3ITM6</accession>
    <name>A0A2H3ITM6_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pre-mRNA-processing factor 17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WOLCODRAFT_86696</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH33330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3ITM6"/>
    <dbReference type="STRING" id="742152.A0A2H3ITM6"/>
    <dbReference type="OMA" id="VQVYDHH"/>
    <dbReference type="OrthoDB" id="10257301at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000034">
        <property type="entry name" value="Pre-mRNA-processing factor 17, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032847">
        <property type="entry name" value="PRPF17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43979">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43979:SF1">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="2 9" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="300"/>
            <end position="334"/>
        </location>
    </feature>
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</entry>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
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                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
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    </evidence>
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    </evidence>
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<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
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    <name>A0A2H3IU70_WOLCO</name>
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            <shortName evidence="9">LS</shortName>
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    <reference evidence="12 13" key="1">
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                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>[[Fe-S] cluster scaffold protein carrying a second [4Fe-4S](2+) cluster] + N(6)-octanoyl-L-lysyl-[protein] + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine + 4 H(+) = [[Fe-S] cluster scaffold protein] + N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + 4 Fe(3+) + 2 hydrogen sulfide + 2 5'-deoxyadenosine + 2 L-methionine + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:16585"/>
            <dbReference type="Rhea" id="RHEA-COMP:9928"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:14568"/>
            <dbReference type="Rhea" id="RHEA-COMP:14569"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:33722"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:78809"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="2.8.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="9">Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the radical SAM superfamily. Lipoyl synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.8" evidence="9"/>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH33512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3IU70"/>
    <dbReference type="STRING" id="742152.A0A2H3IU70"/>
    <dbReference type="OMA" id="PYCDIDF"/>
    <dbReference type="OrthoDB" id="3231at2759"/>
    <dbReference type="UniPathway" id="UPA00538">
        <property type="reaction ID" value="UER00593"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016992">
        <property type="term" value="F:lipoate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000036">
        <property type="entry name" value="Lipoyl synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00206">
        <property type="entry name" value="Lipoyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031691">
        <property type="entry name" value="LIAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003698">
        <property type="entry name" value="Lipoyl_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00510">
        <property type="entry name" value="lipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004019">
        <property type="entry name" value="PRK05481.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009544">
        <property type="entry name" value="PRK12928.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10949">
        <property type="entry name" value="LIPOYL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10949:SF0">
        <property type="entry name" value="LIPOYL SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16881">
        <property type="entry name" value="LIAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00271">
        <property type="entry name" value="lipoyl_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01058">
        <property type="entry name" value="lipoyl_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="7 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="11">
        <location>
            <begin position="120"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="19"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="351"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PCH33512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="389" mass="42687" checksum="B63AC6BA49AF5B2C" modified="2018-01-31" version="1">MVRPGCSMNSILRSASVARRTPHVRTLATPSSSKSSFSQALAEGPTLDDFISGNAPDRVVLGNTKGPRLPSYLKTSIPKGASYTKIKNDLRGLNLHTVCEEARCPNIGDCWGGKEGASPEEGRSAATATIMLMGDTCTRGCRFCSVKTSRAPPPLDPHEPENTAEAISRWGLGYIVLTSVDRDDLADGGAHHFAETIRKIKQKAPHILVEALTGDFAGSLPHVSVVAKSGLDVYAHNIETVEALTPFVRDRRATFRQSLSVLEHAKKEGVRVTKTSIMLGVGEAEDQVMDALRELRKIDVDVVTFGQYMRPTKRHMKVDRYVEPAEFERWKQVAEDMGFMYVASGPLVRSSYKAGEFYIENVLRGKAAEKRTKKLLADQDLAEALDKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IUH4</accession>
    <name>A0A2H3IUH4_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein O-GlcNAc transferase</fullName>
            <ecNumber evidence="3">2.4.1.255</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WOLCODRAFT_60860</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD-104</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 41 family. O-GlcNAc transferase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.255" evidence="3"/>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH33636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="742152.A0A2H3IUH4"/>
    <dbReference type="OMA" id="GFRDRWH"/>
    <dbReference type="OrthoDB" id="421121at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097363">
        <property type="term" value="F:protein O-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029489">
        <property type="entry name" value="OGT/SEC/SPY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44998">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44998:SF1">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--PEPTIDE N-ACETYLGLUCOSAMINYLTRANSFERASE 110 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13844">
        <property type="entry name" value="Glyco_transf_41"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 8" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="TPR" evidence="8">
        <location>
            <begin position="233"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="8">
        <location>
            <begin position="599"/>
            <end position="632"/>
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    </feature>
    <feature type="repeat" description="TPR" evidence="8">
        <location>
            <begin position="633"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="domain" description="O-GlcNAc transferase C-terminal" evidence="10">
        <location>
            <begin position="837"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="domain" description="O-GlcNAc transferase C-terminal" evidence="10">
        <location>
            <begin position="1112"/>
            <end position="1280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
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    </feature>
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        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="74"/>
            <end position="85"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005386"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011970"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
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    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PCH33636.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="1373" mass="154071" checksum="0BFFE23E8D7C1693" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IUQ9</accession>
    <name>A0A2H3IUQ9_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Imidazole glycerol phosphate synthase hisHF</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="9">Glutaminase</fullName>
                <ecNumber evidence="9">3.5.1.2</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="9">Cyclase</fullName>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WOLCODRAFT_94028</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The glutaminase domain produces the ammonia necessary for the cyclase domain to produce IGP and AICAR from PRFAR. The ammonia is channeled to the active site of the cyclase domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 9">
            <text>5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine = D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24793"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="ChEBI" id="CHEBI:58525"/>
            <dbReference type="EC" id="4.3.2.10"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-glutamine + H2O = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the HisA/HisF family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the C-terminal section; belongs to the HisA/HisF family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.2" evidence="9"/>
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        <property type="protein sequence ID" value="PCH33712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="742152.A0A2H3IUQ9"/>
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    <dbReference type="OrthoDB" id="10254903at2759"/>
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        <property type="reaction ID" value="UER00010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000107">
        <property type="term" value="F:imidazoleglycerol-phosphate synthase activity"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01748">
        <property type="entry name" value="GATase1_IGP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HisF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Imidazole glycerol phosphate synthase hisHF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Aldolase_TIM"/>
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    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
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        <property type="entry name" value="GATASE"/>
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    <dbReference type="InterPro" id="IPR006062">
        <property type="entry name" value="His_biosynth"/>
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        <property type="entry name" value="HisF"/>
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        <property type="entry name" value="IGPS_HisA/HisF"/>
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        <property type="entry name" value="IGPS_HisHF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010139">
        <property type="entry name" value="Imidazole-glycPsynth_HisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
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        <property type="entry name" value="IMP_synth_hisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21235:SF2">
        <property type="entry name" value="IMIDAZOLE GLYCEROL PHOSPHATE SYNTHASE HISHF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21235">
        <property type="entry name" value="IMIDAZOLE GLYCEROL PHOSPHATE SYNTHASE SUBUNIT HISF/H IGP SYNTHASE SUBUNIT HISF/H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00977">
        <property type="entry name" value="His_biosynth"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036936">
        <property type="entry name" value="IGPS_HisHF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4 9" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="5 9 11" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="3 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="12">
        <location>
            <begin position="5"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="10">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="10">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="10">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="241"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR036936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR036936-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PCH33712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="571" mass="61233" checksum="8FF2BCD701E9A379" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IVM1</accession>
    <name>A0A2H3IVM1_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 14">6-phosphogluconate dehydrogenase, decarboxylating</fullName>
            <ecNumber evidence="10 14">1.1.1.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">WOLCODRAFT_22036</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10 14">
            <text>6-phospho-D-gluconate + NADP(+) = D-ribulose 5-phosphate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:10116"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="EC" id="1.1.1.44"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10 14">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 10">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10 14">Belongs to the 6-phosphogluconate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.44" evidence="10 14"/>
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        <property type="reaction ID" value="UER00410"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="F:phosphogluconate dehydrogenase (decarboxylating) activity"/>
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        <property type="term" value="P:D-gluconate metabolic process"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:pentose-phosphate shunt, oxidative branch"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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    </dbReference>
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        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="6PGdom_BS"/>
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        <property type="entry name" value="PRK09287.1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0311">Gluconate utilization</keyword>
    <keyword evidence="5 10 14" id="KW-0521">NADP</keyword>
    <keyword evidence="6 10 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8 10 14" id="KW-0570">Pentose shunt</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase C-terminal" evidence="15">
        <location>
            <begin position="181"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="12"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="35"/>
            <end position="37"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="77"/>
            <end position="79"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12">
        <location>
            <begin position="131"/>
            <end position="133"/>
        </location>
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        <location>
            <position position="193"/>
        </location>
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        <location>
            <position position="262"/>
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        <location>
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            <position position="454"/>
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        <ligand>
            <name>substrate</name>
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        <source>
            <dbReference type="ARBA" id="ARBA00002526"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004874"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008419"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000109-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000109-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000109-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000485"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM01350"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH33475.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="491" mass="53541" checksum="0D8850A9889D9D5D" modified="2018-01-31" version="1">MSAPTGDIGLIGLAVMGQNLILNMNDKGFTVVAYNRTTSKVDAFLENEAKGTKIQGAHSIEELVAKLKRPRKIVLLVKAGPAVDAFIEQLVPHLEQGDIIIDGGNSHYPDSIRRTKELEAKGLLFVGSGVSGGEEGARYGPSLMPGGSPAAWPHIKEIFQAAAAQVNGEPCCDWVGETGAGHYVKMVHNGIEYGDMQLIAEAYDILKRGLGLGEDEIADIFESWNKGVLDSFLIEITANILKFKDDDGEPMVSKILDKAGQKGTGKWTAIAALDAGMPVTLIGEAVFARCLSSIKEERVRASKVISGPQKEEFKGDKKQFIDDLEQALYASKIISYAQGFMLMRETAKELNWNLNYAGIAQMWRGGCIIKSVFLGDITSAYTKKPALESLLFDDFFNKAVHKAQPGWRRIIAQAVLWGIPTPAFSTALAFFDGYRSEVVPANILQAQRDYFGAHTFRVLPGKENEKLKAREDIHINWTGRGGNVSASTYVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IW86</accession>
    <name>A0A2H3IW86_WOLCO</name>
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        <submittedName>
            <fullName evidence="2">RabGAP/TBC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_61458</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="PCH34250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:small GTPase binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
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        <property type="entry name" value="Rab_GAP_TBC_domain"/>
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    <dbReference type="PANTHER" id="PTHR47219:SF9">
        <property type="entry name" value="GTPASE ACTIVATING PROTEIN AND CENTROSOME-ASSOCIATED, ISOFORM B"/>
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    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
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        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="1">
        <location>
            <begin position="181"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH34250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="456" mass="51307" checksum="A563272DB4F94D2D" modified="2018-01-31" version="1">MPAGVPSLVPSPDEDPDGFHVRSTYAQLDVWGVRGDGIEEGVERTRARVGGSRASELRAHEALANADEKTRELTTQEVSMLASLDRYGFFVTPTHDRTILLPVAPLLKPLARMATANTNGPTSAPTVSSLPQATISPKELARVAKWGRMLEARSRDPGQNVDAWGIKAAKEHKLHERTFKGIPDCWRSAAWDTLMCRFSKHGKAETTRLAEEYRKALERPSTYDVQIDLDVPRTISGHIMFRTRYGKGQRSLFHVLHCLSLHCDTCGYCQGMGPIAATLLCYFEPTRTYAALVRLHDAYQMHTIFQPGFPGLLEAIYVQERITEQLMPAVYAAFKKHMVSTTSYATKWYITLFANSVPFQTQLRLWDVFLLEGHDIFVVIAVAIVWVYRDHITSDSANFETVLSLLSSFFVPEDENALLSWIGKVISDKKLRSSMQQWRADWQRLVAAGQHNQALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IWN6</accession>
    <name>A0A2H3IWN6_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">DNase I-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">WOLCODRAFT_130230</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">MD-104</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the neutral sphingomyelinase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH34151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3IWN6"/>
    <dbReference type="STRING" id="742152.A0A2H3IWN6"/>
    <dbReference type="OMA" id="IEESSMF"/>
    <dbReference type="OrthoDB" id="387657at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004767">
        <property type="term" value="F:sphingomyelin phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038772">
        <property type="entry name" value="Sph/SMPD2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16320:SF24">
        <property type="entry name" value="PHOSPHODIESTERASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16320">
        <property type="entry name" value="SPHINGOMYELINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="375"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="403"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="14">
        <location>
            <begin position="9"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PCH34151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="457" mass="49921" checksum="9CA5BECD23E080DB" modified="2018-01-31" version="1">MSESHLRTLTLNCWGLKYVSKHRTERIAAIATVLAASDYDIITLQEVWVHGDYEHIRASVSNRLPYSKFFYSAALGAGLAVFSRFPIIGAAINPYSLNGSPIEVIQGDWFVGKAAASVLVAHPVLGQVQVFNTHLFAPGGDSGPLHLQAHRLVNAWEFAKLARQAAEAGRYVIAAGDFNSSPTSLPMSVIRDHADLTDAWAASHPEIPPATSGLPTPMDAVHSFGITADSPLNSFSAGKHLESVARKFHGKRLDYIFFRQPSSPPASNKTPILTCTDTRVVFTDLVPGTNFSFSDHFGLEATFTISLPEGGDVLNPENTYIPAPAEPRSPNFVLTSVPSPAPVPPRALSPDSITDILQALMAAYRFSLYRSRSQLTVFAVCIMLLLVILVGSAWLPGPGANPLVIFITIFLAWLATTFLYVGFVYGRWEVNALTNVIEELEIYRGSLQHWQNHERAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IX84</accession>
    <name>A0A2H3IX84_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_139431</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467832">
        <property type="protein sequence ID" value="PCH34566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3IX84"/>
    <dbReference type="STRING" id="742152.A0A2H3IX84"/>
    <dbReference type="OrthoDB" id="3226064at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH34566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="335" mass="38271" checksum="A87993DB70D9D149" modified="2018-01-31" version="1">MMVRSSSSSFGRQPRCLLLSAACPRNSSNASYSSATRATLQTFSRTCRSAYQLAYQDDDQYLWRELFLSRPFDDLRKTVPPLIPSKPLEQHDWRSELQRRVEAEIVVGREELAGDPRLPRALETLVSIVETALPISDGPESDTSESLQWLDPLLNKLTKLDANSVTVPERKLLARLMAYVVLSYERSSDDSLGDEATKRRLRELRKHSRCYVYDLRRCKPETYYGPYTPGADGEIVANWEHVMHVVNVVALKLWELPMLALRLYCKPPAGLSSTQTYSAPFSHDRKPYDWAGVEGTWRRFVCFMDYRITFRGTATQNTLTTSTRGPSVRLSCTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IY24</accession>
    <name>A0A2H3IY24_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_165880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467832">
        <property type="protein sequence ID" value="PCH34882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3IY24"/>
    <dbReference type="STRING" id="742152.A0A2H3IY24"/>
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    <dbReference type="OrthoDB" id="2746321at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH34882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="574" mass="64582" checksum="B04CE9C2CB9B8E57" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IYI2</accession>
    <name>A0A2H3IYI2_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">E2 ubiquitin-conjugating enzyme</fullName>
            <ecNumber evidence="1">2.3.2.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WOLCODRAFT_91390</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="1"/>
    <dbReference type="EMBL" id="KB467843">
        <property type="protein sequence ID" value="PCH35060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3IYI2"/>
    <dbReference type="STRING" id="742152.A0A2H3IYI2"/>
    <dbReference type="OMA" id="VHFTTRI"/>
    <dbReference type="OrthoDB" id="7851174at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23792">
        <property type="entry name" value="UBCc_UBE2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000010">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2-16 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="8">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PCH35060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="147" mass="16399" checksum="0644AFB2E2C543C9" modified="2018-01-31" version="1">MALKRINKELIDLGRDPPSSCSAGPTGDNMFQWQATIMGPGDSPYAGGVFFLSITFPTDYPFKPPKVSFTTKIYHPNINANGSICLDILRDQWSPALTISKVLLSICSMLTDPNPDDPLVPDIAHLYKTDRARYEATAREWTRKYAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IZW2</accession>
    <name>A0A2H3IZW2_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_159826</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH33083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3IZW2"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH33083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="204" mass="21840" checksum="36C2DAF90E13E68C" modified="2018-01-31" version="1">MGASQQSLPGHTASFSHPTSIYLQSTSAFSLCLHHARSPNALFHSAWGAAVAKCSDVSCTLKRMGTLSLSSQDTPDGVNTSLRYASEASAFVVARGERTTVRILRISPIGCQSDDLRADQGGLALRKNIKNACTYTGDSLRLNQFRSLTTNSSTGVSKLSVSEEGTTIDNDGNVVYPFSVETIPDSLAITGEIFWIFVSQRNEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J0I0</accession>
    <name>A0A2H3J0I0_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PLP-dependent transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WOLCODRAFT_107775</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD-104</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467854">
        <property type="protein sequence ID" value="PCH35742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J0I0"/>
    <dbReference type="STRING" id="742152.A0A2H3J0I0"/>
    <dbReference type="OMA" id="HEVIHKY"/>
    <dbReference type="OrthoDB" id="3512640at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054542">
        <property type="entry name" value="Cys_met_metab_PP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808:SF35">
        <property type="entry name" value="CYSTATHIONINE GAMMA-SYNTHASE (AFU_ORTHOLOGUE AFUA_7G01590)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="TRANS-SULFURATION ENZYME FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PCH35742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="264" mass="29236" checksum="796B0D0C3F4D19B4" modified="2018-01-31" version="1">MDARWWQYSSLTPSNLAATLALAHNRRCNMAPQTDQKPRLTGTELIHGDDELVHGAEVAPSISVTSTFRAPLSPDGSLQEDIDFRNPQRHVYSRYTQSVSTRAERVLSKINGGFAITYASGLAASYAALVYFHPKRIAITGGYPGFHNTIDVYKRSRSGDLPLIGLDDELQPGDLCWLETPLNPTGEARDIKYYADKVHAAGGKLIVDSTFAPPPLQYPFKWGADMVLHSGTKYFGGHSDLLSGVLVVPTEAEWKIVRDRYRFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J225</accession>
    <name>A0A2H3J225_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Wax synthase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WOLCODRAFT_156442</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB467854">
        <property type="protein sequence ID" value="PCH35745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J225"/>
    <dbReference type="STRING" id="742152.A0A2H3J225"/>
    <dbReference type="OMA" id="IMPEDAV"/>
    <dbReference type="OrthoDB" id="1077582at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032805">
        <property type="entry name" value="Wax_synthase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13813">
        <property type="entry name" value="MBOAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Wax synthase" evidence="5">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PCH35745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="113" mass="12453" checksum="CDBFCFFFF6AC1718" modified="2018-01-31" version="1">MLRRFTTSIGKAVCQLLCLRPRSKASSYMHLYVTFVVSGIMHCGGDPMVGRGILCASFPFYLMQAIAIMPEDAVIGIARKRGLTSSSGWTRFVGYIWSRCGSVSLRRGLRTGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J2D2</accession>
    <name>A0A2H3J2D2_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_28525</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467876">
        <property type="protein sequence ID" value="PCH36392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J2D2"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH36392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="56" mass="6489" checksum="1E0A3B3688FE789F" modified="2018-01-31" version="1" fragment="single">MRTASRKNTAFIDYTHFSSPDCPTTFSFPDICDISPDAFRHHYVMRCVLTTSSRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J2Y2</accession>
    <name>A0A2H3J2Y2_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WOLCODRAFT_147203</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD-104</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH33099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J2Y2"/>
    <dbReference type="STRING" id="742152.A0A2H3J2Y2"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
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        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
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        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="401"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PCH33099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="402" mass="44581" checksum="4C6CE22BA4D99FDA" modified="2018-01-31" version="1">MLYVSDPGALTTILLREPANFEEGSSYVNANILVFGPGISSLSGEPHRKHKRILAPAFSATEIREMLPTVRVVAAKLHNAITSRIANGSQEIDIMHWLSRATLEIIGQAGLGHSFDSLIGEERDDFGKVVNTIFPIMGELSIFRPFLPAMFSFGTPTWRRCLVDIIPFGPIKRLRQLADAMNAMSTKIYRMKQYELRTNPKLLQQIKESKDIISSLLRANLDTSSRGGLNEREVTADISLMITAATDTTATTISRILQLLSQHPDYQERLRTELRDTAGLDELPFEELNKLPLLDAVLKETLRLYPPGGLTREVQKDTVLPLYQPVYCPDGTVLSEIPLPAGTEVMVGILGCNTSKAIWGEDALEWKPERWLSPLPSSITDASIPGVYSNIMTFVGGKRSCM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J3D1</accession>
    <name>A0A2H3J3D1_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WOLCODRAFT_82480</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="PCH36742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="742152.A0A2H3J3D1"/>
    <dbReference type="OMA" id="WPLINDS"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051219">
        <property type="entry name" value="Heterochromatin_chromo-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056924">
        <property type="entry name" value="SH3_Tf2-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22812">
        <property type="entry name" value="CHROMOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24626">
        <property type="entry name" value="SH3_Tf2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="4">
        <location>
            <begin position="84"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PCH36742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="187" mass="21886" checksum="82406FF2601CF325" modified="2018-01-31" version="1">MVKKVPFKVGDKVMIDVWDYQTSERSLAPHYIGPFKIIKQLSPVTFRLHLDAQYRAYHPVFHASKLVPYTGSQEAPDPDEHGEYEVEEILDHRYSRPGGKLQLLVRWKGYTQGEDTWKDKVALQNAKEIVDEYKQKHKLNDAPGRRSAHNPRIKVADPEDDPDWKVGDRYLWSDDWPLINDSMTREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J3Y2</accession>
    <name>A0A2H3J3Y2_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CNH-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WOLCODRAFT_108638</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467876">
        <property type="protein sequence ID" value="PCH36385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J3Y2"/>
    <dbReference type="STRING" id="742152.A0A2H3J3Y2"/>
    <dbReference type="OMA" id="CFRQKII"/>
    <dbReference type="OrthoDB" id="2272012at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="DEP_fRom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041675">
        <property type="entry name" value="PH_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052233">
        <property type="entry name" value="Rho-type_GEFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572">
        <property type="entry name" value="RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572:SF2">
        <property type="entry name" value="RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00780">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00610">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15405">
        <property type="entry name" value="PH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00036">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00049">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
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    </dbReference>
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    <sequence length="1192" mass="133716" checksum="924013DA735EC8F9" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J3Y8</accession>
    <name>A0A2H3J3Y8_WOLCO</name>
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        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
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        <name evidence="13" type="ORF">WOLCODRAFT_135746</name>
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    <organism evidence="13 14">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="13 14">MD-104</strain>
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        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
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        </reaction>
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        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
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        <text evidence="10">Belongs to the protein kinase superfamily.</text>
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    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="50"/>
            <end position="417"/>
        </location>
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            <begin position="1"/>
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    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="79"/>
        </location>
        <ligand>
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        </ligand>
    </feature>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
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</entry>
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    <accession>A0A2H3J483</accession>
    <name>A0A2H3J483_WOLCO</name>
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        <submittedName>
            <fullName evidence="8">Cytochrome P450</fullName>
        </submittedName>
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        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Phaeolaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
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                <person name="Riley R."/>
                <person name="Barry K."/>
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                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
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                <person name="Heitman J."/>
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                <person name="Kallen N."/>
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        </source>
    </evidence>
    <sequence length="292" mass="30433" checksum="0ADA317BAF5B2A6F" modified="2018-01-31" version="1">MAEVGIHTLTSSSKPETAGVRSTSIPAPPAHASTPSAHSTSSKLTASTSGTSRTVQVHITSSSSTTQGQRETVTSKITVMDTTTANGSTLTVTYSVPTTATTRSPATNVQTISSASTHTSPTGNNNSLSISQYSTIAVESSLSPLSIAPSVTAATLSSSSRGSFPVKDIVGIAIASSLSLALLLLLTRWLYSKRDRGLAVTPYNLPREVYPARRQRPPDRPSPFDAGSSDELQTPAARSHIPALRLDMRSPPAARTPRWSCDGALSSPGLHPVQKADVPHSRTSPAMSMSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J7R8</accession>
    <name>A0A2H3J7R8_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_115192</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH38280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J7R8"/>
    <dbReference type="OMA" id="ESTYHRK"/>
    <dbReference type="OrthoDB" id="17066at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH38280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="231" mass="26632" checksum="EDCBFEBA405A4B66" modified="2018-01-31" version="1">MSRLASFKGPSTPNASPVRVKQQQQPPSPTRLAESTYHRKARTLLQELSAVTETWDDIVLIDGLKAAKSLVDTRTELDNELSLMPEKTLPAYHIVGPKLSLMEQRISELDAVLVKLRKLFSRMNAIVDSLEAVLFEAHKMKGWKWVQEPLWVTWSLEKFVSSIPQILTPYHRSLEMHAELVDILRHHDVSFEVSREAIAKWVAQPHLEEYSWEAQWEDLCEAEIDRWDGPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J813</accession>
    <name>A0A2H3J813_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Mitochondrial ribosomal protein L17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WOLCODRAFT_135315</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL17 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH33778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J813"/>
    <dbReference type="STRING" id="742152.A0A2H3J813"/>
    <dbReference type="OMA" id="WQWFTRR"/>
    <dbReference type="OrthoDB" id="275000at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1030.10">
        <property type="entry name" value="Ribosomal protein L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01368">
        <property type="entry name" value="Ribosomal_bL17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000456">
        <property type="entry name" value="Ribosomal_bL17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047859">
        <property type="entry name" value="Ribosomal_bL17_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036373">
        <property type="entry name" value="Ribosomal_bL17_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00059">
        <property type="entry name" value="L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14413:SF16">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL17M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14413">
        <property type="entry name" value="RIBOSOMAL PROTEIN L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01196">
        <property type="entry name" value="Ribosomal_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64263">
        <property type="entry name" value="Prokaryotic ribosomal protein L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01167">
        <property type="entry name" value="RIBOSOMAL_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PCH33778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="282" mass="31477" checksum="58EF954F71F5FF8D" modified="2018-01-31" version="1">MKHGIAFRKFSRTSSHRMLMLRNLVTSLFEHEQIKTTLPKAKDTARLAEKIITMGKKGTLPAFRRANAFLLKPSIVPKVFQTFAKRYATRPGGYTRIHKFGNRPGDNAPHAILELVDNPRDLRFEMTARAVGWDLLSKRVRNAGPGASSLKGISGVEDVLTEERRLGNNERGDLRNWTRVNLQKVLRYREEDAVVGVATKAEDHVDTLLAQSLAAKKAAKDAEAADETPYAGVKALRLKAGQTLPGGTRSTLHLAQGALGKEYTGRLRWFERRKLGIDTKQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J820</accession>
    <name>A0A2H3J820_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RlpA-like protein double-psi beta-barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WOLCODRAFT_22254</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH33788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J820"/>
    <dbReference type="STRING" id="742152.A0A2H3J820"/>
    <dbReference type="OMA" id="WETVTDI"/>
    <dbReference type="OrthoDB" id="623670at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22191">
        <property type="entry name" value="DPBB_RlpA_EXP_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051477">
        <property type="entry name" value="Expansin_CellWall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009009">
        <property type="entry name" value="RlpA-like_DPBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836:SF28">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03330">
        <property type="entry name" value="DPBB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013890940" description="RlpA-like protein double-psi beta-barrel domain-containing protein" evidence="3">
        <location>
            <begin position="19"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="RlpA-like protein double-psi beta-barrel" evidence="4">
        <location>
            <begin position="230"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PCH33788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="284" mass="29566" checksum="E6108EE4B5EABEB5" modified="2018-01-31" version="1">MFVPKAVVALAVALYASALSVPHSARNAAHHRSIAVRHAEPEAAPVPAAQPESVIVKPKRKRSLNKRCLPRSSSAALSATSAASSAVPSSSAVVSSVLSSVAPSSSEVATSSAAPINIGGLPPIFSSSSVETPSSTYVAPTTSETPTYTPTSTYTPTTSYAATTASSADISEPTWMYETNSGDATYYAAGLGACGITNTDSDYIVAVSWELFDNYPGYDGTNPNTNPVCNKQITANYEGKSVTVTVTDRCTGCDTTSLDFTPTAFQQMADLSIGRLYGMTWQFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J8A0</accession>
    <name>A0A2H3J8A0_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_23380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH38446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J8A0"/>
    <dbReference type="STRING" id="742152.A0A2H3J8A0"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="227"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH38446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="478" mass="53469" checksum="EB52773DA4955119" modified="2018-01-31" version="1">MDVSYMTLWKPNEPLERSCAASTLADRVADRNLSALARELKFDETIAEITVDRGDASHQIVHVIVQTDLHPRERHIEEQDSGSRQRQERSEEINAGIDTAVAALMETRNSTLFHAKNRLPPSESARPVNYRNYQGGEAPLLDGRVGEGQTFRDTLAAPVELYCPAFSEFLTGLTDEPSQDVVKRIREMTLSQMLTYSMDRSITLGESAEDLIAKKPPPNETVALVIVEEDPELGSGDFDPTTKVSYSYERFWASVEYQHIFNASCCPSFLIARSGSWLCVLGAVWTTHVVVQRLTDFVWLGTSPRIDDSCRLNVARVTSSLRKAIVTLRRFYASFDTSAPPRGVLPCFLCPWIKSYYVGRLESDIDHSALPAAGPVQLYPRGPSEDDEEVEEVLDQVERALTVLHGAGLVYGDLHRPNVMVTDEGKVQLVDFDSAGKEGAVRYHPFISTSQRWPSGVKPYAMIKAEQDREMLNFLRAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J8D0</accession>
    <name>A0A2H3J8D0_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Acyl-CoA desaturase</fullName>
            <ecNumber evidence="16">1.14.19.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">WOLCODRAFT_23420</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Stearoyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:19721"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:57394"/>
            <dbReference type="EC" id="1.14.19.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="16">Expected to bind 2 Fe(2+) ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.1" evidence="16"/>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH38512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J8D0"/>
    <dbReference type="STRING" id="742152.A0A2H3J8D0"/>
    <dbReference type="OMA" id="WAHKSYN"/>
    <dbReference type="OrthoDB" id="10260134at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004768">
        <property type="term" value="F:stearoyl-CoA 9-desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006636">
        <property type="term" value="P:unsaturated fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03505">
        <property type="entry name" value="Delta9-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000004">
        <property type="entry name" value="Acyl-CoA desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009160">
        <property type="entry name" value="Acyl-CoA_deSatase_haem/ster-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015876">
        <property type="entry name" value="Acyl-CoA_DS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001522">
        <property type="entry name" value="FADS-1_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351">
        <property type="entry name" value="ACYL-COA DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351:SF31">
        <property type="entry name" value="DESATURASE 1, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000345">
        <property type="entry name" value="OLE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00075">
        <property type="entry name" value="FACDDSATRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00476">
        <property type="entry name" value="FATTY_ACID_DESATUR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0249">Electron transport</keyword>
    <keyword evidence="15 16" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="8 16" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 16" id="KW-0349">Heme</keyword>
    <keyword evidence="12 16" id="KW-0408">Iron</keyword>
    <keyword evidence="4 16" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="13 16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 16" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="18">
        <location>
            <begin position="363"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR000345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PCH38512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="465" mass="52912" checksum="5CE2A7D59A4D543E" modified="2018-01-31" version="1">MPPVSVIEASPPLISPPMTEPEVPTNYVEWVVKNQKPLPPISWSNWWNELNRLTLAILTITPAISIYGAFNVKLCRETAVLSVVYYFITGLGITAGYHRLWSHRSYNASKPLQYFLAMAGAGAVQGSIRWWCRGHRAHHRYTDTELDPYDANKGFLWSHVGWMIVKPRRKPGTADVSDLTKDPVVRWQHCWYVYLILAMGFLLPTVVAGLGWSDWRGGFFFAGAARLCFVHHSTFCVNSLAHWLGEKPFDDKHTPRDHVITALVTVGEGYHNFHHQFPMDYRNAIKWYQYDPTKWFIWACHKAGLASHLKTFPDNEVRKGQLTMQLKHLRETQEKLTFAPDVNELPVISWESFQKQSVTRPLILIAGFIHDVSSFVDEHPGGRHYIAKYIGKDATTAFFGGVYDHSNAAHNWLSMMRVGVLHGGMQHGLDDKSVPPSQRLRIAQYKEIMAGNGSSTSWTDEEGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J8G4</accession>
    <name>A0A2H3J8G4_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase</fullName>
            <ecNumber evidence="7">2.7.8.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WOLCODRAFT_135922</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a CDP-1,2-diacyl-sn-glycerol + sn-glycerol 3-phosphate = a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + CMP + H(+)</text>
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            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60110"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the CDP-alcohol phosphatidyltransferase class-II family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.5" evidence="7"/>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH37915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="10250191at2759"/>
    <dbReference type="UniPathway" id="UPA00084">
        <property type="reaction ID" value="UER00503"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008444">
        <property type="term" value="F:CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09137">
        <property type="entry name" value="PLDc_PGS1_euk_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016270">
        <property type="entry name" value="PGS1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12586:SF1">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12586">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--SERINE O-PHOSPHATIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="4 7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PCH37915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="401" mass="45174" checksum="92107FF971302300" modified="2018-01-31" version="1">MHLDYNRCTRPEALSTANMLLPLLREFPERAHVWLFRSPNLKGLMAKLMPPRFNEGWGGTWHPKIYGADDEILISGANLNTSYFTNRQDRYIHFAAQPALAQYCFSFLEQASVFSYELLPAPSPSEGYILHWSDERTHPHHTEQKAENALKSFQRARLAESRTTLSSAPAGEPDPATGSDSDVLIFPIVQAGQFHIREEEECLDKLFRYISPPEASPVDTPLVDLTSGYFGLYKPYQEQLIKANIAARVLAASPKANGFYASKGVSGRIPEGYTVLERRFMKALRAAGREWPHDTRTTSTGVQLSEWERDGWTYHAKGIWVRPTQVEDPVLTLFGSTNLNSRSANLDTELSFMLVTTSPVLRARLAQEVDGLRAHALPWQGDKRTVRPVSWLLASALCDRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J8T2</accession>
    <name>A0A2H3J8T2_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_139759</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467843">
        <property type="protein sequence ID" value="PCH35149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J8T2"/>
    <dbReference type="STRING" id="742152.A0A2H3J8T2"/>
    <dbReference type="OMA" id="TRSTHET"/>
    <dbReference type="OrthoDB" id="107110at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33266">
        <property type="entry name" value="CHROMOSOME 15, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33266:SF1">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="595"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH35149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="738" mass="82330" checksum="C0879F99961DF515" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J9B5</accession>
    <name>A0A2H3J9B5_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_140389</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
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                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467954">
        <property type="protein sequence ID" value="PCH39110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
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        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH39110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="341" mass="37792" checksum="C27D1290CCD272E1" modified="2018-01-31" version="1">MTNPYAPVNETSAEIWFEESNYVSTFIGAIAYGVHIVIFFTCVYYLIKERGKHFWQWLVIVFTLFSMATINICINIRFGQLAWIDDRNYPGGPLAYLLDNQSDSINTAGNATSFVALICADGILIFRVLVLWQSWYIVVFPFLMWLASTALSILVCVQTARPNSSLWANNTFDFYVPYWSISIALNIILTLLLITRLMYVRQKVVPSMGGQYGKLYTAVATMVLESALPYSVVSIIFIILYGMKVTAENLFIPLLVQVACIAPEVIILRVTRGRALSSDLIPGQNISSMKFGSGGSRGHTSDSSSAGQVGIAEHLSMMTFPPGSAETSLPSYGKKAVEYIV</sequence>
</entry>
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        <lineage>
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        </lineage>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CBP3 family.</text>
    </comment>
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        <property type="protein sequence ID" value="PCH34578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JA77"/>
    <dbReference type="STRING" id="742152.A0A2H3JA77"/>
    <dbReference type="OMA" id="WFTVTNL"/>
    <dbReference type="OrthoDB" id="10253878at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Ubiq_cyt_c_chap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007129">
        <property type="entry name" value="Ubiqinol_cyt_c_chaperone_CPB3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12184">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX ASSEMBLY FACTOR 1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12184:SF1">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME-C REDUCTASE COMPLEX ASSEMBLY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03981">
        <property type="entry name" value="Ubiq_cyt_C_chap"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="110"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquinol-cytochrome c chaperone" evidence="3">
        <location>
            <begin position="207"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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            <begin position="30"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PCH34578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="373" mass="42008" checksum="FD8BBE90818500F6" modified="2018-01-31" version="1">MVPRSIYAACFRQTSITSRLRNVRFIASGSAAPTPASKPGPEPQQPPRRQKSWLTRKAESSPITKNAVLRLAQLLGYGSTKQVAGRRAFVMYEKLCILRPDEERAFWQNECDLPPTFQSWFTVVNLHVWLLTVRLRALPQPQSKQHIQALIDHFFLDIEDRVRAILQPAAPDSTASSSPVGPYTPLTDFYKVANLPGKTRPKGRAPERLVTQQMRIFKEQWAGMGMSFDASLLHGDAEMAGVIWRNFLGGRGARGIVYPSTAPTNKPYFRRAVNLVGGEVEKVKKIDQRGLEVEERRDDGSGVHDYAPTEADKYVAYPELMATLVAYIRRELLRLQRLPDDVITGPRTPGSEGDHIERLKFGKVRAGTLFEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JBF6</accession>
    <name>A0A2H3JBF6_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Mitochondrial glyco protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_139683</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
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        </lineage>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
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                <person name="Benoit I."/>
                <person name="Boyd A."/>
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                <person name="Copeland A."/>
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                <person name="Ferreira P."/>
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                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
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                <person name="Hesse C."/>
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                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467843">
        <property type="protein sequence ID" value="PCH34998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JBF6"/>
    <dbReference type="STRING" id="742152.A0A2H3JBF6"/>
    <dbReference type="OMA" id="RWLNNVK"/>
    <dbReference type="OrthoDB" id="278212at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Mitochondrial glycoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR036561">
        <property type="entry name" value="MAM33_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10826">
        <property type="entry name" value="COMPLEMENT COMPONENT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10826:SF1">
        <property type="entry name" value="COMPLEMENT COMPONENT 1 Q SUBCOMPONENT-BINDING PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02330">
        <property type="entry name" value="MAM33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54529">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH34998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="264" mass="29533" checksum="2F1560BA891C7BEE" modified="2018-01-31" version="1">MSAIRALRQISLSSTRALAARAASRSLTRSALPVFAARAAPASRAFSVSARAFGEGSVDPYLSQKLGEELQYEQSSFAAEEPEFLKTFKAQGVWEIEDVPGNDEVAITRKFGNETIRLMFSIADIQNEPEQEFEQEESDVDPEELSRSYPIRCSFSITKAGANGAITVDAMCQEGEFIVDNMSFYNDAKLGTELTAEADWKRRGLYIGPQFDTLDVSVQEGFEKFLHERGISEPLALFVPEYAEYKEQKEYVSWLKNVKTFIEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JBR3</accession>
    <name>A0A2H3JBR3_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ubiquitin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WOLCODRAFT_139744</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH33577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JC93"/>
    <dbReference type="STRING" id="742152.A0A2H3JC93"/>
    <dbReference type="OMA" id="YEMPMAL"/>
    <dbReference type="OrthoDB" id="3266199at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="31"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH33577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="294" mass="32481" checksum="474C22C6353EA5FB" modified="2018-01-31" version="1">MASPDSEGALQAMHSIPCEIKWHPSFASPDTDVILCSNDDTAFRVYSHTLKTTSGLFASMFSLPRNTPHALASDIIRLDEDANVLASLLKMVSGMDFPPLVSIDFVDALLRAAEKYDMPGPASIIRNSLPSPLLEGSPIRIYGIAYRQGWFKEAAEVSRRTLGLDLCSPDVSRELAKIDAAAVVKLFELRRKRMESMVDCLNDHARFNVAGDATSICKNCSTPLQHVKWRSLQCAWALLVEKNGLTDEAIEIPEVVEACNAECTKCQERMYNETVTLRALRSVIKALPLTIELP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JCI0</accession>
    <name>A0A2H3JCI0_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">agmatinase</fullName>
            <ecNumber evidence="4">3.5.3.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WOLCODRAFT_23753</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>agmatine + H2O = urea + putrescine</text>
            <dbReference type="Rhea" id="RHEA:13929"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:58145"/>
            <dbReference type="ChEBI" id="CHEBI:326268"/>
            <dbReference type="EC" id="3.5.3.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="5">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the arginase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.3.11" evidence="4"/>
    <dbReference type="EMBL" id="KB468053">
        <property type="protein sequence ID" value="PCH39962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JCI0"/>
    <dbReference type="STRING" id="742152.A0A2H3JCI0"/>
    <dbReference type="OMA" id="CIDAGFV"/>
    <dbReference type="OrthoDB" id="288726at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008783">
        <property type="term" value="F:agmatinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033389">
        <property type="term" value="P:putrescine biosynthetic process from arginine, via agmatine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019627">
        <property type="term" value="P:urea metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11592">
        <property type="entry name" value="Agmatinase_PAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.10:FF:000006">
        <property type="entry name" value="Agmatinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.10">
        <property type="entry name" value="Ureohydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020855">
        <property type="entry name" value="Ureohydrolase_Mn_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358:SF30">
        <property type="entry name" value="AGMATINASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358">
        <property type="entry name" value="ARGINASE/AGMATINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036979">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00116">
        <property type="entry name" value="ARGINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01053">
        <property type="entry name" value="ARGINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013924412" description="agmatinase" evidence="8">
        <location>
            <begin position="20"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00050304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00066392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR036979-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PCH39962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="400" mass="43013" checksum="3CA64A1926745DC9" modified="2018-01-31" version="1">MLPFASLSALLLLSAAVIAHEGYDDDMQMPLDYVRFPYQATYPGDNEVTADSIFSGITTFAKLPWVQCLGKDKNVAFDVAFIGAPFDTGTSYRPGARFGPAGIRAGSRRLTLYGGYNVPLEVNPFLSGLKIVDCGDIPVTPYDNKYAIQQIEDGHKALLHRPTFSPLGNDSATGLPLQPISADGKYHPRIITLGGDHTIVLPLLRSIYSAYGAISVIHFDSHLDTWKPQVFGGAPSEQAAINHGTYFYWASQEGLIKNGSSIHGAIRTTLSGPADYANDDASGFQRIEAREIDTIGTAGIIKKIRETVGDRPVYLSIDIDSIDPAFAPATGTPETGGWSTRELRTILRGLDGLHIVSADIVEVAPAYDTNAELTTMAAADVLYEVLSVMAKTPLGKVPAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JDA4</accession>
    <name>A0A2H3JDA4_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_146375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467887">
        <property type="protein sequence ID" value="PCH36709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JDA4"/>
    <dbReference type="STRING" id="742152.A0A2H3JDA4"/>
    <dbReference type="OMA" id="CIATSIT"/>
    <dbReference type="OrthoDB" id="2576334at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="375"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH36709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="440" mass="47445" checksum="A863072D148FBA26" modified="2018-01-31" version="1">MYLWTSSSQIKEMARTCSDFELTMRSITMIIFSSPYRMTKLSLSANIPVKHRDVRTAQLCPLPLNLLECSLCINFFPYRDGPVDSQWNVSYSDSRFSDWSSNPFGVGMYGHEPTMQKSSHNTTLIGAYALLEWAGTGVWFYGTMRNGEYTIQIDDGIPSSGDGAIDGVLFGQDGLAYGFHKALINVTGNTEMSSITGATITVGMGESGTVRLQRTINATVNSGSLAANPLFVVNDGSEWSAETLYGNQSHPYPCIATSITGSSISFNLNESVGFALYGSDDYQQGLFVVNYSPRSQWTELNQLKFIATGMNQSQTYNVDITNLGANFNLASVVVYSAIPSPGNSKSISANSLASAPLPKPSSALLPVSRSLDTGAIAGAAIGGFVAVLIVAVLVVLAIRRRRRQQEAAALLTVPTISDLLPCGMSQTQRKEVAQSEICGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JDE3</accession>
    <name>A0A2H3JDE3_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitochondrial intermediate peptidase</fullName>
            <ecNumber evidence="4">3.4.24.59</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Octapeptidyl aminopeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">WOLCODRAFT_112898</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion.</text>
            <dbReference type="EC" id="3.4.24.59"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="15">Binds 1 zinc ion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the peptidase M3 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.59" evidence="4"/>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH33977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JDE3"/>
    <dbReference type="STRING" id="742152.A0A2H3JDE3"/>
    <dbReference type="OMA" id="ALMFEYM"/>
    <dbReference type="OrthoDB" id="17530at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006518">
        <property type="term" value="P:peptide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06457">
        <property type="entry name" value="M3A_MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000055">
        <property type="entry name" value="Related to mitochondrial intermediate peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.10">
        <property type="entry name" value="Neurolysin, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033851">
        <property type="entry name" value="M3A_MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024077">
        <property type="entry name" value="Neurolysin/TOP_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804:SF79">
        <property type="entry name" value="MITOCHONDRIAL INTERMEDIATE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804">
        <property type="entry name" value="PROTEASE M3 THIMET OLIGOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 15" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 15" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9 15" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M3A/M3B catalytic" evidence="16">
        <location>
            <begin position="288"/>
            <end position="760"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PCH33977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="778" mass="87011" checksum="2C24F88D270DE8E4" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JDN4</accession>
    <name>A0A2H3JDN4_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNA polymerase II-associated protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WOLCODRAFT_98684</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the RPAP3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468053">
        <property type="protein sequence ID" value="PCH40316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JDN4"/>
    <dbReference type="STRING" id="742152.A0A2H3JDN4"/>
    <dbReference type="OMA" id="MEIREYM"/>
    <dbReference type="OrthoDB" id="629492at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101031">
        <property type="term" value="C:protein folding chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051966">
        <property type="entry name" value="RPAP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025986">
        <property type="entry name" value="RPAP3-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46423">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46423:SF1">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13877">
        <property type="entry name" value="RPAP3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13414">
        <property type="entry name" value="TPR_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="5">
        <location>
            <begin position="6"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="RNA-polymerase II-associated protein 3-like C-terminal" evidence="7">
        <location>
            <begin position="113"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PCH40316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="234" mass="25404" checksum="F9E5AC2DEDFDF7AD" modified="2018-01-31" version="1">MSTAKGQAEKDKGNAAFKTGDYATAVGHYSAAIVADPANATYPLNRAAAYLKLGKNEDAERDCSTVLRLDARNVKALFRRGQARGALQRLGDAREGAKPKPAATLNESTSTRPPMTLFAFTKRWEKEREGRWQLLNEIPPPALPALFQSSLDATLLGSMLHTFRDVLTAGGADGDAVRAQVCAYLTSLARVPRFGTVLLFMSAEERKLAREVWHLVGVSGAQSEVERQAWGLDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JE41</accession>
    <name>A0A2H3JE41_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Prolyl 4-hydroxylase alpha subunit Fe(2+) 2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_136899</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468053">
        <property type="protein sequence ID" value="PCH40476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JE41"/>
    <dbReference type="STRING" id="742152.A0A2H3JE41"/>
    <dbReference type="OMA" id="QHWASAT"/>
    <dbReference type="OrthoDB" id="27483at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33099">
        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33099:SF14">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT FE(2+) 2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prolyl 4-hydroxylase alpha subunit Fe(2+) 2OG dioxygenase" evidence="2">
        <location>
            <begin position="181"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="411"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="483"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="485"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH40476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="508" mass="57342" checksum="8C93246643EC541F" modified="2018-01-31" version="1">MAVINITEMPSQHIRRQLRLMSSGLTHLRATRATQWCNGSFLHTGREKQAKNTAVPDFTKQLESLRASITYQPPFCKGTLSVKDEDYILFYGKSKSGNARRIHLAKAASDELDHLESTCDAAPFGINNQNVLDETYRKAGKLDTSEFMTGFDPQRLGLLDTIRTDLFEGNERRNITAELYKLNVYGKNSFFKAHKDTPRAEDMFGSLVIAFPTAHEGGSFILLDSALMVADRTKPCVAYIAFYSDVEHEITPVKSGHRVTLTYNLYFTPDTAARRSGQIPRSDKQDTALAFKSTFQRLLDDPTFLPEGGKLGFNLRHEYPGRPDMDLQTLLGNLKGADAVIEEVCAELALPSSVKVIMETNAWGEQLTRIMLSKYPDIRGVQDVGGEGRELFEILREDYNGKLLDEVRSPFQEEYDEEDLENLEDGEEPEDLTAYPDLTVHWVTETPEPNRVEGAFICYGNEPMVDSAYANFCLVVEVEPAGKRQTTRRRRRRKPEGKKGNQPQSLIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JEU8</accession>
    <name>A0A2H3JEU8_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WOLCODRAFT_44977</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH40752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JEU8"/>
    <dbReference type="STRING" id="742152.A0A2H3JEU8"/>
    <dbReference type="OMA" id="HNESHIR"/>
    <dbReference type="OrthoDB" id="541276at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050205">
        <property type="entry name" value="CDPK_Ser/Thr_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24349">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="23"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PCH40752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="294" mass="33466" checksum="104534D52EA26117" modified="2018-01-31" version="1" fragment="single">MVQFSAILPSFLGVVLTSGDMRLRMLEVLGHGAYGVVYLAQDLNYSSSQPKYYAVKCLLKQPEDSEHYRLQQREISYHKAASSLPNVVRLHQVIEDDFYMYLVLDYCPGGDLFSAIIDRGVFIDHNERLRRTFLQLLDAVHDCHDIGIYHRDLKPENIMCSADGEDIYLCDFGLATRHKLSVNFGCGSSFYMSPECIGDCTGRKPFVTSISDIWSLGIILTNLITSRNPWHVASPSEDVAFAAYLQQGETWLRRMLPISRGACSILARIFVIEPERRITLHELRNAIKELNSFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JF33</accession>
    <name>A0A2H3JF33_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_157012</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467876">
        <property type="protein sequence ID" value="PCH36298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="742152.A0A2H3JF33"/>
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    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH36298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="436" mass="49135" checksum="1A8FD3A99E25D2C6" modified="2018-01-31" version="1">MEEATQLMIAAIKAQTSQSPLRTFAIAYIHDLEDIASKSAEEVERQQLCISYVDELETIPAKAYIRLLDFCMVKKTPRPYTFCHGSNISQQQSSVQTPLPGARATRNASPPLDDLPGADIIIRTSDMVEFRVHRVILNMGAPGLLRISPTPYQHSPDSSDNGIPSSNALPLLQLAEKCETISTLLRMCYPCDSPILLSNFDALYTAAKKYSMQMVMDRLRHELINLLKGCDDSEPYYLLACRHSFKDIVYKSAKAFSERDLGVWIAVERKPKSIWRQSFDAVPASAVFRLLQFHRKTKAEALALTSKWVPKPHRFGNVFDPTTTFDAVANACQLPAYRPSRYPCWLSLFMSKVRPVLEEKPRGSSIRDKVMDILLDLQGELLNAQSKQICTMCRRSITTEQLKRMVRDFADKVDEVANKVNLPSAIASSMVIESHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JF78</accession>
    <name>A0A2H3JF78_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WOLCODRAFT_98482</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD-104</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
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        <property type="entry name" value="COMT-like"/>
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        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012967">
        <property type="entry name" value="COMT_dimerisation"/>
    </dbReference>
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        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF2">
        <property type="entry name" value="O-METHYLTRANSFERASE CICE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Methyltransf_2"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SAM_OMT_II"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase dimerisation" evidence="5">
        <location>
            <begin position="80"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="4">
        <location>
            <begin position="261"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PCH40195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="451" mass="49877" checksum="6592E48ADABD7CF8" modified="2018-01-31" version="1">MSSRSKTDQLRSLLRLLNDAANTILTEWEAEEQIILDSSQPVTHPSVPTAELFEARRIFLGACGMCIDIVQDPLIRLTEVVFSHLTAAALRVAAEARIADILAKADPNEGLSIKEITRQCGIQDWKLVRVLRCLCGLNIFAETRNECFINTPTSHQLVGNEQLRFNSSMEMSAASAKLSAVLFDPIKTKSTSPRETAFQEAFATTMTLWEYLEHVSKGSSASSLGQTPLDIWTTGMTAGAQVELPTLCMDYPWGDLGPCLVIDVGGGVGGKSLELAKHYPNLRFIIQDREDVLVQAHAVWHRDYPAALAAGRVAFMPHDFFTKQTVIGADIYLLGNILHDWPDDECVTILKNLRQAMKLDSRILVIDQVVHTTVGSPSMKTAPPPLLPNYGYASHYAATRTLSMLTLFNGTERTPEELEALAAQSGLKVMKIWECRSMAYITELRRADVVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JFL6</accession>
    <name>A0A2H3JFL6_WOLCO</name>
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        <recommendedName>
            <fullName evidence="7">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </recommendedName>
    </protein>
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    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
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                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467854">
        <property type="protein sequence ID" value="PCH35504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
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    </dbReference>
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        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017956">
        <property type="entry name" value="AT_hook_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000116">
        <property type="entry name" value="HMGA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02178">
        <property type="entry name" value="AT_hook"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00929">
        <property type="entry name" value="ATHOOK"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00930">
        <property type="entry name" value="HIGHMOBLTYIY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00384">
        <property type="entry name" value="AT_hook"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="9"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="41"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PCH38089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="153" mass="16121" checksum="3381397BAC30885E" modified="2018-01-31" version="1">MSASPPPEDPTENQQQDELEDPPADAEIAAEPAEEPEHPPPKRKRGRPPGSKNKKTIAATTGEAAPASSGAPAANATPSPDQPKRGRGRPPKRKSEDEVAATSSDPPVKRKRGRPPKKKPEVSGDEDAGEAPAPESSAQPRKKRGRPRKDASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JHI3</accession>
    <name>A0A2H3JHI3_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycerophosphocholine acyltransferase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">WOLCODRAFT_137340</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GPC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH41341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JHI3"/>
    <dbReference type="STRING" id="742152.A0A2H3JHI3"/>
    <dbReference type="OMA" id="WKRRVPT"/>
    <dbReference type="OrthoDB" id="406287at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006656">
        <property type="term" value="P:phosphatidylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021261">
        <property type="entry name" value="GPCAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31201:SF1">
        <property type="entry name" value="GLYCEROPHOSPHOCHOLINE ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31201">
        <property type="entry name" value="OS01G0585100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10998">
        <property type="entry name" value="DUF2838"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="163"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="284"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="347"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="374"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="416"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PCH41341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="466" mass="53457" checksum="AFB141F2A7B7EE20" modified="2018-01-31" version="1">MGSPDSSRPPSPPAMRTPDMPSSGLSHFSVPFERFARDDISDWASGFTLLDTLETYWDSRVDLLQRRLSKQSERLKIKAEETLNEMFKKDLFKRRPSISTSQQFEREMQKFKVKVSSRLLSLAAAWHSANVVRTREKLTFFWGVMSLLFTALMFSMAPEWTHVAYTLQAAFYLPLRVYMYKKRAWHYFLFDLCYYANILNFVYIWLVPTSPALFVACYCLSHGSLASAVITWRNSLVFHDFDKVTSLFIHVYPPLTFTVIRHFYPNAQERFPALAELPHLQPMRALLLSGLIYLIWQVLYWKFVFVDRRTKVESGQRITSLSFLLNDKRGVIGLSLSKVPREHRETVFMAGQFVYSIMTELPAVYVLYDSPFWSGSFLIFIFAVSVWNGGGFYVEVFGRKFEKELEALRKELAEVTSRSSGSSPILGPQSDDELTTVGGSPNIVDKALSPEISSTDLPIDTKPAAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JHQ9</accession>
    <name>A0A2H3JHQ9_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_166763</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467876">
        <property type="protein sequence ID" value="PCH36224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JHQ9"/>
    <dbReference type="OMA" id="WHITLIV"/>
    <dbReference type="OrthoDB" id="2804213at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH36224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="278" mass="29612" checksum="F1990C22A4B7CCA9" modified="2018-01-31" version="1" fragment="single">MNACSSCEALMILQGAASTFLFAVAAVFSALRVYAISGRKWHITLIVLLTSLVPVATAIRSLAVILYGVVLRVDDLIICGYESSGSASVATRSAIATFTCVIASELIVIGVTFSPVFLVTNSFVKIKLQSSIVTVLLKDGALYFVALLLLNVLLLLGNMAPNAYGAFAGYVEAFLPSLGNIIISRFIFNLRDITTAQNDSRRLSHGPAIDCTVSSRAQASESIQFSSKIIANIGAPLNYSTSVDLALEDGDIDDVGCNESDWFEEADDEMQLDAGFEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
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                <person name="Barry K."/>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
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    </dbReference>
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</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
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    </dbReference>
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    </dbReference>
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        <location>
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            <end position="25"/>
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    </evidence>
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</entry>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
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                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
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                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
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                <person name="Nagy L.G."/>
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                <person name="Pisabarro A."/>
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                <person name="Martin F."/>
                <person name="Cullen D."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="PCH42011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="103" mass="11543" checksum="E54194F147D33ACC" modified="2018-01-31" version="1">MARSAVISRDSDSQSVTVALVINGYLGTTPISPSLAISLRSLELLYTIRLFKASFSIESFGKLMCHLYKVPFKQRFRALVADMFEIYLIIRRNVDKQVLAALG</sequence>
</entry>
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        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
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                <person name="Lundell T."/>
                <person name="Martin R."/>
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                <person name="Morgenstern I."/>
                <person name="Morin E."/>
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                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
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                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
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                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468124">
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            <end position="161"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH41875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="161" mass="17306" checksum="162896011408656A" modified="2018-01-31" version="1">MSHARRGPPCTPRSAADSCSSGRGESKYKHRPRKPTLFALPLLCVVSPTEARRSSTVHRREAHLRGSARGPGGPPRPAAQQQYPDRQPGSTAAKRALARHVAAARGCTARREPSARTAAPATPPRAHRADARGPTPSRDKTPRAAARRREAKPRRAASGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JK27</accession>
    <name>A0A2H3JK27_WOLCO</name>
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        <recommendedName>
            <fullName evidence="5">TFIIS N-terminal domain-containing protein</fullName>
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        <name evidence="6" type="ORF">WOLCODRAFT_132245</name>
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        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
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        <lineage>
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            <taxon>Phaeolaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
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                <person name="Kohler A."/>
                <person name="Kuees U."/>
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                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
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                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
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                <person name="Slot J.C."/>
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                <person name="Stenlid J."/>
                <person name="Sun H."/>
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                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Transcription factor involved in RNA polymerase II transcription regulation. May function in both SPT15/TBP post-recruitment and recruitment steps of transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IWS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468124">
        <property type="protein sequence ID" value="PCH42201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="742152.A0A2H3JK27"/>
    <dbReference type="OMA" id="MPAYNIQ"/>
    <dbReference type="OrthoDB" id="21124at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.10">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051037">
        <property type="entry name" value="RNAPII_TF_IWS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035441">
        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017923">
        <property type="entry name" value="TFIIS_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46010">
        <property type="entry name" value="PROTEIN IWS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46010:SF1">
        <property type="entry name" value="PROTEIN IWS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08711">
        <property type="entry name" value="Med26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51319">
        <property type="entry name" value="TFIIS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TFIIS N-terminal" evidence="5">
        <location>
            <begin position="261"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="73"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="74"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="113"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00037992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PCH42201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="436" mass="49581" checksum="8960C4A6AD3A4FF4" modified="2018-01-31" version="1">MRYAYAAFSNLVNFQFRPNTRKVTRGHAAQRHCRLARPLRTIHLRAIGLHLQDLHQWSVRCKLSENDLEREIFGSDDELSSPDEDDIQEKSYGAPSGAQAVYESSGDSGDDYVQEKRQAKSREGGRGRRSQRIGEGGAKGAKTPRQPKRKRKEIEEVDMSQLPPAQANRLKLDMKIDAILKPNRASKPRRKKKDDDDVLDRFADETVARLKEDMFAAAHDDEQAKREKRPATSKLKMLPRVMDVMRKNALTESIIDNNLLEAVTRWLKPSFDRSLPALDIQKEFFPALKRMDIDTGALKEARLGPVVLFYTKCKRVTPDIQRHANDLVSAWSRPIIKRSASYRDRVIPVANMPEEGARTGGERLNAILARAKEGEKNRVRKNAVMIPQRELGSYTIAPHSSAVLGRNSMSVDVDIERRKKNAERLRSLTRKIASKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JKU9</accession>
    <name>A0A2H3JKU9_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable acetate kinase</fullName>
            <ecNumber evidence="5">2.7.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Acetokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WOLCODRAFT_120042</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>acetate + ATP = acetyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:11352"/>
            <dbReference type="ChEBI" id="CHEBI:22191"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from acetate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the acetokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.1" evidence="5"/>
    <dbReference type="EMBL" id="KB468124">
        <property type="protein sequence ID" value="PCH42155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JKU9"/>
    <dbReference type="STRING" id="742152.A0A2H3JKU9"/>
    <dbReference type="OMA" id="HKYVSQR"/>
    <dbReference type="OrthoDB" id="67445at2759"/>
    <dbReference type="UniPathway" id="UPA00340">
        <property type="reaction ID" value="UER00458"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008776">
        <property type="term" value="F:acetate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006083">
        <property type="term" value="P:acetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006085">
        <property type="term" value="P:acetyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00020">
        <property type="entry name" value="Acetate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004372">
        <property type="entry name" value="Ac/propionate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000890">
        <property type="entry name" value="Aliphatic_acid_kin_short-chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023865">
        <property type="entry name" value="Aliphatic_acid_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00016">
        <property type="entry name" value="ackA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21060">
        <property type="entry name" value="ACETATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21060:SF15">
        <property type="entry name" value="ACETATE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00871">
        <property type="entry name" value="Acetate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000722">
        <property type="entry name" value="Acetate_prop_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00471">
        <property type="entry name" value="ACETATEKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01075">
        <property type="entry name" value="ACETATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01076">
        <property type="entry name" value="ACETATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="230"/>
            <end position="234"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="422"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="5">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="5">
        <location>
            <position position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PCH42155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="438" mass="47535" checksum="C5F9826F83EB9CC0" modified="2018-01-31" version="1">MANSETACQSGLILAVNAGSSSLKISLFRRRNSDAKPVQPDHVVELLLVSSITQISSSPALFSFSLASHTQGREVKKESVDNINDHASAFSHFLDYLKTEASIERSEIVHVCHRVVHGGDYFEPVIINSESYHHIKILSDLAPLHNGAALSVIKGCIDALPHANSIAYFDTSFHRSIPLHIASYAINPDVAKKRGLKKYGFHGLSYAYILGAVSHYLQQDASTLNLIVTHLGSGASICAIRAGRSLDTSMGLTPLSGLPGATRSGAVDPSLIFHYTNRAGRITHDPSQAVDVRVTQAEEILNTQSGWRALTGTADFAEVVKNAGWAGEGRWRLAFELLVDRISGFVGQYSVRLEGRVDALVFAGGIGEKSVELREAVVKQTACLGFELDEAANRTANEKDGPVVDVGKSKDQRRVLVCRTDEQLEMAKECALADKFWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JKV5</accession>
    <name>A0A2H3JKV5_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_82676</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467887">
        <property type="protein sequence ID" value="PCH36637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JKV5"/>
    <dbReference type="STRING" id="742152.A0A2H3JKV5"/>
    <dbReference type="OMA" id="CESIMNC"/>
    <dbReference type="OrthoDB" id="2804045at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH36637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="167" mass="18531" checksum="4B27B6C382808C8A" modified="2018-01-31" version="1" fragment="single">LYTFDYVITFDREVHLVWSRKASGSSILFLLFRYLTLAWITMYIAINTSTACKVCESIMNCRSDMATFIALRVYGISGGSPKVPLVVLFIGLMPPALYLTAVVTIVLSICSILDDGLVLIVTWYTTHGLNKAARQAGIEVSLVGLLLRDGKARLKELFASMKFLIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JL11</accession>
    <name>A0A2H3JL11_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Carboxypeptidase</fullName>
            <ecNumber evidence="7">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WOLCODRAFT_161558</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="7"/>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH38418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JL11"/>
    <dbReference type="STRING" id="742152.A0A2H3JL11"/>
    <dbReference type="OMA" id="KQDYVEC"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033124">
        <property type="entry name" value="Ser_caboxypep_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF113">
        <property type="entry name" value="SERINE CARBOXYPEPTIDASE CTSA-4.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00560">
        <property type="entry name" value="CARBOXYPEPT_SER_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7 8" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013424833" description="Carboxypeptidase" evidence="7">
        <location>
            <begin position="26"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PCH38418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="502" mass="55494" checksum="FEB21DE64D66FE83" modified="2018-01-31" version="1">MWSVYVRKIVLIALVAAICAAMSCATQQPLSYHTDGDASTPQMNDNPEEFRPIDDLNLLSETDFTTLQHSALPYYNVRVKKSKFCDGTVVAYTGYIDIEARHLFFYFFESRNKPEQDDVIFWTNGGPGGSSSFGLFMELGPCAVKDATSTVFNPYSWNSKADVFFIDQPVGVGFSYAGYGESVSTTPEAAKDIAAFVSIFFERFSKFKGKPFHMAGESYGGRYIPVFASAVYDNNAKLVAAGLPPINLTSVIIGNGATDSGLVMISYYEMQCKPVSIPPIQDISTCVRMKQAIPRCQKMVQESCYDRFESFGCKAAELFCTEEFDSTFPPNLNPFDITKECEPEDNGVCYSVVRDIEAYLSRPDVRATLGVDRAIPANFSAINFEVNAAFWAAQDQWFQNQLYIAELLERGVKALIFAGVNDIACSWVANDKMTRSIEWSGQAEFVAQPLREWEVAGAAAGVTRSAGPLTFATVYGAGHMVPLDKPREAQEMVNRWMAGVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JL19</accession>
    <name>A0A2H3JL19_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_58811</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468135">
        <property type="protein sequence ID" value="PCH42892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JL19"/>
    <dbReference type="OMA" id="SKPAMHE"/>
    <dbReference type="OrthoDB" id="3210574at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH42892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="144" mass="15150" checksum="80A051AD250C24A7" modified="2018-01-31" version="1" fragment="single">NNAYVSQPPPAHHIHRDSEALPGARGGSSAADYSADVTNDSRTWTDNNQRRFGAGTDDSHIMAGGQHDSPGASRATSGSDAGHNAFNQERPLDVEPTSQGGVAIGGQDNLPEGRAKLTDKLIGKTQKVAGKATRNPEMHERGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JL38</accession>
    <name>A0A2H3JL38_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_88104</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH38448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="2802356at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH38448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="421" mass="41525" checksum="AAAB1A4532D2B143" modified="2018-01-31" version="1">MVAYAHYQSATDGWGTPGYRFGRPPVPSFTPESSWGGLDYYRAHAFRGGPQFYQSVMGRMSSAVGVGFNEARYWHRRIYGGLVNLSQVLPADVGSAAAYEAYRIWKYHQQNVFQPLGGDIERMREAMIAMAVAEATQLWQYTGRALDSYGRQDAGEAAAATASRIARTVLVAETGGLGVGAAPGYGGMVDGGATPAAAGLGAGMAGGSINPLDYANRAGLNPLSYTNPAGAGANPLGYANGAGAGGVHARDYAYSGRPRGLRRASSVDSTISAGYAGREVGAATPISSAAGSLVGGGVGGVVSPVGGAGVATPLGGGAGVTAGYPAGVTYVQPGATAYGAGGLGGGTGMGGVLPSASGYGGYGGYGGYGGYGGYGGYGGYGGYGVQPGLAGPGGVGALGGVGAMGGYQYPGRGTTIGERGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JLC6</accession>
    <name>A0A2H3JLC6_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_89955</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468124">
        <property type="protein sequence ID" value="PCH42681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JLC6"/>
    <dbReference type="OMA" id="GRIWGPE"/>
    <dbReference type="OrthoDB" id="2425321at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="331"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="372"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="404"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH42681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="506" mass="55272" checksum="2150C4ED055DDEDA" modified="2018-01-31" version="1">MSTEKPLPVPPSPTSPKYSFPAVLKHDPNLKPNPHPYAVKTTTSGVLSRSNSSSHNVNVTRHYYVPSSPSTGHSPDNGKSHKMSKSLSTIADSPTRPSPRPLPTPPMLTAPLIDDHQTNGLHMEGEHQPSRRNKRAETLPSIPSDSYQAPTPLVVPTEDLPPNPKLWTPAQLSTYLVTALRISSQGKQGDSQPIVLPSRVAKDIAAFAKARLINGRMFLRLTDAELESMGMNKKWREALLVASQQLRQNVLKGRIWGPEVSRDPSPNSTSPLPIHPFSSSLYSSSTSSLELSADEGDSGADTTPSKRVRLTLVCSNVFSALRVFAIGGREWLFATVTFLLGMVPVATNLFGDVKTIYSTIFTYRILKEAHRANIKASVVTLLLRDGTALLILNVLHLSLSLTNVFLDVTYFVTAFSSIIVSRFLLNLRQIHLVTDDDDSNPSFVQTSSDQGTTLEFNSTISTLDQESGFMDCYPWEMEGGKAADPSDVHVTELATIGQHGLESDVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JLT5</accession>
    <name>A0A2H3JLT5_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Defective in cullin neddylation protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_138222</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity.</text>
    </comment>
    <dbReference type="EMBL" id="KB468135">
        <property type="protein sequence ID" value="PCH43160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JLT5"/>
    <dbReference type="STRING" id="742152.A0A2H3JLT5"/>
    <dbReference type="OMA" id="LWCKFLQ"/>
    <dbReference type="OrthoDB" id="27198at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097602">
        <property type="term" value="F:cullin family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032182">
        <property type="term" value="F:ubiquitin-like protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.200">
        <property type="entry name" value="Cullin, PONY binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014764">
        <property type="entry name" value="DCN-prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042460">
        <property type="entry name" value="DCN1-like_PONY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005176">
        <property type="entry name" value="PONY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12281:SF31">
        <property type="entry name" value="DCN1-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12281">
        <property type="entry name" value="RP42 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03556">
        <property type="entry name" value="Cullin_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14555">
        <property type="entry name" value="UBA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51229">
        <property type="entry name" value="DCUN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DCUN1" evidence="2">
        <location>
            <begin position="58"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU410713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH43160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="279" mass="31398" checksum="86900CC7F9AB4C4B" modified="2018-01-31" version="1">MSSRSSRARSDLETSISQFVSVTGASTRDARRYLERHKRLDAAIDAFYNDPGAARSGASTTKLNALFDQYKDPDAEEITVDGTIRLCQDLCVDPEDVVLLAVAYELRSPRMGEWSRKGWVDGWRALGHDTLPAMQGALARLRERLGADPEYFQKVYNYTFDFSRQAGQRSLALDMAQAFWALLIPHGLAGGALAHVAGDEDEDEAMGAEEGWKDEYTTWWFEFLTEKGGRGVSKDTWQMFLEFVRMIDARFEKYDAEAAWPSTLDDFVEYARARLASGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JM55</accession>
    <name>A0A2H3JM55_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Non-heme 11 kDa protein of cytochrome bc1 complex</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WOLCODRAFT_138276</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UQCRH/QCR6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468135">
        <property type="protein sequence ID" value="PCH43280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JM55"/>
    <dbReference type="STRING" id="742152.A0A2H3JM55"/>
    <dbReference type="OMA" id="NTCNDRV"/>
    <dbReference type="OrthoDB" id="405848at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.20">
        <property type="entry name" value="Ubiquinol-cytochrome C reductase hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003422">
        <property type="entry name" value="Cyt_b-c1_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023184">
        <property type="entry name" value="Ubol_cytC_Rdtase_hinge_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036811">
        <property type="entry name" value="Ubol_cytC_Rdtase_hinge_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15336:SF0">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15336">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX 7.8 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02320">
        <property type="entry name" value="UCR_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81531">
        <property type="entry name" value="Non-heme 11 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Ubiquinol-cytochrome C reductase hinge" evidence="10">
        <location>
            <begin position="49"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="20"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PCH43280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="111" mass="12448" checksum="AA5E671CBC41C3E1" modified="2018-01-31" version="1">MSITEYLSSLFPVAHADAPEEKEEETKEEESTEETEEAAEEEEEEEPEDILPALRDECAQSAKCAAATKHFQHCEEKVNAGKGFPHEDCVEEFMMHCVDGCVAPKLFAKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JM93</accession>
    <name>A0A2H3JM93_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">H-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_167658</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467943">
        <property type="protein sequence ID" value="PCH38848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JM93"/>
    <dbReference type="STRING" id="742152.A0A2H3JM93"/>
    <dbReference type="OrthoDB" id="5419324at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2080">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037221">
        <property type="entry name" value="H-type_lectin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019019">
        <property type="entry name" value="H-type_lectin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09458">
        <property type="entry name" value="H_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141086">
        <property type="entry name" value="Agglutinin HPA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="H-type lectin" evidence="2">
        <location>
            <begin position="120"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH38848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="283" mass="29797" checksum="F559B51096376A90" modified="2018-01-31" version="1">MSFTGTPDEGSVALVSTSNTPKISGEEQIGQPQYFSGFSTAHVTDGRGDKKTFQLSTSVQSNGSKITATADAQYSSSVLAGAVVNWLKVGAYDRDFQAGISTVVSQQLNKGFVLKGFVNTVQFAKGFNSKPNVVAWISGIKLVNPSTWSIKVSATAITTGGFDISIDGPAQDIDALDVTWIAYPASRGHITSGELSFSSPVPVLETGDQVETFRSTRLESPPRILLGVSGFEIVNKNGKFDLEVTTSGVTPAQFNWKASVKDGAGSPKTLVSLTAAYVAVVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JMS5</accession>
    <name>A0A2H3JMS5_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_138373</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM72 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468146">
        <property type="protein sequence ID" value="PCH43492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JMS5"/>
    <dbReference type="STRING" id="742152.A0A2H3JMS5"/>
    <dbReference type="OMA" id="VLFWHHL"/>
    <dbReference type="OrthoDB" id="2526683at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026768">
        <property type="entry name" value="YPEH2ZP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31841">
        <property type="entry name" value="PROTEIN FAM72A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31841:SF1">
        <property type="entry name" value="PROTEIN FAM72A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14976">
        <property type="entry name" value="YPEH2ZP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="119"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="231"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="344"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="121"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="344"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH43492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="382" mass="40965" checksum="A91BEB33A3B88775" modified="2018-01-31" version="1">MVNPYGQYAAVDRAYPSPSASLPSHSQYAYPLPPRNGHVLVPSHTPLQMHSTAHPPWHPHVRVQVMPPPPPMVHKVWILDCKSCGMFLTNRGMKAVLLLRPNVPLYSTDALPINCSAYSPDPSPSSPASPPSSPSSSQPPNTSTRTCECLTQTLCCHGCGSAVGYMIVSPCRRCTSSISASNRTTNGHRFVFYSAEVVAGERLYVLGERGVHAFHPPQPLRLVPINSSGLHAASSRARDPPAMSPLSSPRSDTDDDNSMPELVPLEQPVSPGAPPPSRRMSAYPSARTTPDANALSAGSAGVWHTPAGLAVEAIVPPEPERLKAGEVLYWHHLVRSGEIPPVAEDVRARGPRPDDETHAGKDAADTQRRAPVGLKHTVFAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JNF5</accession>
    <name>A0A2H3JNF5_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Gaa1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_96645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
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                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD-104</strain>
        </source>
    </reference>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="entry name" value="LEUCINE-RICH REPEAT PROTEIN SHOC-2-LIKE"/>
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        <location>
            <begin position="619"/>
            <end position="640"/>
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            <begin position="643"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
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        <source>
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            <dbReference type="EMBL" id="PCH44070.1"/>
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            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
    <sequence length="667" mass="72193" checksum="4F7F47C06496CA77" modified="2018-01-31" version="1"> </sequence>
</entry>
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        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="15 16">MD-104</strain>
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        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
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    </dbReference>
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    </dbReference>
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        <ligand>
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        <ligand>
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        <source>
            <dbReference type="ARBA" id="ARBA00012409"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH44262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="369" mass="41985" checksum="97DA83B843E9807A" modified="2018-01-31" version="1">MDAVEKANTERQKRWAKDKKVGEGTYAVVYKGREIATGRKVAIKKIKVGQFKDGLDMSAIREVKFLRELKHQNVIELLDVFSSKTNLNLVLEFLDTDLELVIKDRSLVFLPADIKSWMAMTFRGLEFCHRNFILHRDLKPNNLLIASDGQLKIADFGLARDFADPGYKMTCQVITRWYRPPELLFGCRYYSTAVDIWSVGCIFAELMLRTPYLPGESDMDQLKTIFRALGTPTEEDWPGHTKLPDYVPVGQFPRTPLRELFTAATPDCLNLLSKCLIYEPRRRIGAKEALNHPYFFAHPYPSHPSKLPKPAIKNTLPLEEVDGNVDLSGPGPAVKANPPNKLKRKHSSDDLNGRSIARKLDFTQHTGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JQ45</accession>
    <name>A0A2H3JQ45_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Nop14-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WOLCODRAFT_99589</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
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                <person name="Ferreira P."/>
                <person name="Findley K."/>
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                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
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                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
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                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
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                <person name="Ohm R.A."/>
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                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
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                <person name="Wiebenga A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
            <dbReference type="EMBL" id="PCH43655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="match status" value="1"/>
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        <location>
            <begin position="2"/>
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            <end position="194"/>
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            <begin position="235"/>
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        <source>
            <dbReference type="Pfam" id="PF08635"/>
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    </evidence>
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    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="414" mass="44473" checksum="B21C217452C05B9B" modified="2018-01-31" version="1">MFNILLIGAGEINFGSVEGPWNHSLRLEQVLGADLRVVGLVDPDVTRARAALDGKLAGPTAPAYASCKVFPSVAAAAAGGELAGEASPRVAIVGAPPFVRGSDLPGKDLELQLVSAFSECALFVEKPVSSGAEEACWRVTAELQKKGTLVGVGYMLRYSKAVQRMKQIVRENKLVVMGTNARYVMAYEYARKLASITPASRATVLNLRAVMVGQNVLRRPPPQPSSSKPPISARDLSRYFGGDVSLPSVAAHTVEHDDAPGALSAQRFDEGGIPPARRLPRLTSATWKYKGGAVGALTHVIALHGTTYDTEFEVYADGFRLKLVDPYGSPVLSVRRPGLAGEELISFTDDDPFYTELSTFVEAVKDPKAHGSILSSYEDAVKTYELTWHIRRASEASTAAERERTAQAQESNTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="9" xmlns="https://uniprot.org/uniprot">
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    <name>A0A2H3JQN0_WOLCO</name>
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        <name evidence="2" type="ORF">WOLCODRAFT_24501</name>
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        <lineage>
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            <taxon>Agaricomycetes</taxon>
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            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
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                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JQN0"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH41109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="207" mass="23691" checksum="F7E4172951C3968F" modified="2018-01-31" version="1">MVSLLFSRIRRPNRTRRACGNVDSAARQHSLSSEPRSETVDLDGEAEGQPIRYIDYSSARNLDDTEWYQDIEIHSIDTEELFDWQTAEDDYDAAGTDEFVEQGAGEGIYTVDLGNNWSILSDMRAADRAFDTTFYMMVAEPLEPLSQVDIMRLPGAASDFAWQIEIHERRLEYGPLFRSVLRTPPGRRGSLRTMFPHRSCSMKMEIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="2">Uncharacterized protein</fullName>
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        <lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
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                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
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                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
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                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JRL7"/>
    <dbReference type="OMA" id="PIEYESA"/>
    <dbReference type="Proteomes" id="UP000218811">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="88"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH42543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="253" mass="27929" checksum="33E3F312D35CDB70" modified="2018-01-31" version="1">MWRQSASSEYSTLFSSGLCVITSSNHGRPLSMMAGPSSPLDAESHHSSKKKSHSRTASTPHCHQHAQSALPRVETNVSARDTSKNGHSAPRTASSTTKTKAARKQPQCLDSSIRSWLDDEYRDRDIDQTDSYLNLKTENNRGSPLTGTSFLSFNVSPTESVVSLVPPSRQRRASIQTVPLPPRQSSATRKKRRSVMSVDLSLFAFDRQGGQSPALASKAFDEVIGWNEELPSDWRQGADSPFQDDRSFLITSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
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    <name>A0A2H3JSF9_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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        <lineage>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468168">
        <property type="protein sequence ID" value="PCH45090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JSF9"/>
    <dbReference type="STRING" id="742152.A0A2H3JSF9"/>
    <dbReference type="OMA" id="VMKNIRT"/>
    <dbReference type="OrthoDB" id="2723779at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH45090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="174" mass="19227" checksum="0987A7F0883D4975" modified="2018-01-31" version="1" fragment="single">MASPSSIGSSFHNPPNASPSDDSELEPNAEWKFNVRKSIEADFLPEVRRAKEERDAALSISPADVDKIEQDYRTVMKNIRTVAETRYRMALRAERQERRFAAGLKVDERWIAEQEELLEAIQQETRPALDGAGQSVDVGVGSWRADGVGSLMNKPRQRSVSQQDVGAAGTGATI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JSJ0</accession>
    <name>A0A2H3JSJ0_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GATA-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WOLCODRAFT_90848</name>
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    <organism evidence="9 10">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycotina</taxon>
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            <taxon>Phaeolaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
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                <person name="Sun S."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9 10">MD-104</strain>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
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                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
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                <person name="Benoit I."/>
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                <person name="Ferreira P."/>
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                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">MD-104</strain>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="108" mass="12352" checksum="3DCDD7B89E2079EE" modified="2018-01-31" version="1">MVNRHISADLKACALRLWNSGWDEQDICDALQVSRSSIYRWCRIFAEFGTVNKPPSPLCGQLKIITSVVLNSIQQLYRSDSATFLNELRWWLAVNHDIAISKTVTVTR</sequence>
</entry>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
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                <person name="Barry K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD-104</strain>
        </source>
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    </dbReference>
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        <property type="entry name" value="MYB_LIKE"/>
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    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Myb-like" evidence="6">
        <location>
            <begin position="243"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="7">
        <location>
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            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="6">
        <location>
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        </location>
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    <feature type="domain" description="Myb-like" evidence="6">
        <location>
            <begin position="347"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="7">
        <location>
            <begin position="351"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="434"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="436"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PCH41368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="543" mass="60363" checksum="AEDB331B1426326F" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JVR2</accession>
    <name>A0A2H3JVR2_WOLCO</name>
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        <submittedName>
            <fullName evidence="8">POP1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WOLCODRAFT_88572</name>
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    <organism evidence="8 9">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Phaeolaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    <dbReference type="PANTHER" id="PTHR22731">
        <property type="entry name" value="RIBONUCLEASES P/MRP PROTEIN SUBUNIT POP1"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR22731:SF3">
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        <property type="match status" value="1"/>
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        <property type="entry name" value="POP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        </location>
    </feature>
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        <location>
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            <end position="773"/>
        </location>
    </feature>
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        <location>
            <begin position="46"/>
            <end position="75"/>
        </location>
    </feature>
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        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF22770"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH40247.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JYI8</accession>
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            <fullName evidence="9">MFS general substrate transporter</fullName>
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        <name evidence="9" type="ORF">WOLCODRAFT_164114</name>
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        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Phaeolaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
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            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD-104</strain>
        </source>
    </reference>
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        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="MFS_trans_sf"/>
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    <dbReference type="InterPro" id="IPR051788">
        <property type="entry name" value="MFS_Transporter"/>
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        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514:SF3">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="262"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="381"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="470"/>
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    </feature>
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        <location>
            <begin position="73"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PCH42938.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="478" mass="51153" checksum="AE9E38C31005D099" modified="2018-01-31" version="1">MSEPPTSILHARPLFQPELGAFEATSPLHTDGIELVELGAQAESSSKAADVAEEITQAPPQPTPLQRQKANIQFAAMCFALFLAGWNDGTTGPLLPRIQKVYHIGFAVASLIFVSNCLGFIFGAGANVALTDRLGFGTVMVIGSVFQMAAYSLTAPAPPFPVFVLGFGLNGFGGALQDAGANGYVGCLAHGAETKMGILHAVYGELAPLSEVRIAVILYTCLGAMASPFVATQFAEFQRWSFSYLISLAIALLNTLFLVFVLRFRTQDDCLAEIGQPVPERTSSDDNKYKQIFRLRAVHVLAAFILVYVGIEVAIGGWIVTYIVDVRDGGSSSGYISSGFFGGLMLGRVALLWLNKAVGERTILFIYILLAVGLELVIWLVPSLIGNAVAIAFVGLFLGPVYPIAMNHAGRILPQYLLTGCISWIAGFGQAGSALIPFLTGLLASREGIKSMQPMLVTMMSLMVGLWAIVPNHSRRID</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JYW2</accession>
    <name>A0A2H3JYW2_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WOLCODRAFT_164917</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="KB468157">
        <property type="protein sequence ID" value="PCH44099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JYW2"/>
    <dbReference type="STRING" id="742152.A0A2H3JYW2"/>
    <dbReference type="OMA" id="GCPFDTG"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="28"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PCH44099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="559" mass="60963" checksum="0F7AB9ED1868A4A2" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JYX5</accession>
    <name>A0A2H3JYX5_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WOLCODRAFT_151392</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH41347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JYX5"/>
    <dbReference type="STRING" id="742152.A0A2H3JYX5"/>
    <dbReference type="OMA" id="HTECPRT"/>
    <dbReference type="OrthoDB" id="3884315at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005162">
        <property type="entry name" value="Retrotrans_gag_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032567">
        <property type="entry name" value="RTL1-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503">
        <property type="entry name" value="LDOC1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503:SF22">
        <property type="entry name" value="TRANSPOSON TY3-I GAG POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03732">
        <property type="entry name" value="Retrotrans_gag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="5">
        <location>
            <begin position="239"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="193"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="247"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="89"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="253"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="273"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PCH41347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="323" mass="37135" checksum="D0FC1A82397AEC90" modified="2018-01-31" version="1">MIKINPPDVFDGERSDMQNFINQCNSWFTMYETSFQNDIQRVIFILSYISGKGKTGQWKQNYHRVHTDPTTRRFFPPSLAQFDTDFQKAFGAVQEIQKARRQILKLEQDKKDIDDYITEFNNMAGKAQYDRYSPDGNALLITLFEKGLPDHTTRYIIGMRPMPDNIDAWQEAASYYENTYKIFLRRDKGAQVKKKDWRSSTPRHSGNTSTSAPTSKDLNAMDIDRLTAEERQDHITKGKCFNCHQPGHLSRTCPKKKKGTGRPKGKARKIEEDRSEPDAAIEEVSDEGETEYVTANRAVTAIRTLKARNPGLLSKLLDETDFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JZJ3</accession>
    <name>A0A2H3JZJ3_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_138935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468157">
        <property type="protein sequence ID" value="PCH44319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JZJ3"/>
    <dbReference type="STRING" id="742152.A0A2H3JZJ3"/>
    <dbReference type="OMA" id="NWWLARN"/>
    <dbReference type="OrthoDB" id="428342at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH44319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="430" mass="45525" checksum="2B0A57B6345F9711" modified="2018-01-31" version="1">MKGISLHPRTHSAPSNSSTPSSRAASAINGEAAPQPKGVRKLVKKLQGGIRHISHIGHHPKAAAISAVPVRDQSVVASIPPSHTPVDSIVGIVHDIPALPIAFPLYPKSKTSFDSMSASTLTSEGEPADVTDAHSFDAHSVDRPSSFTSAADHLSIHDSSSVHSASVDASSAYVSAVGDSSTPALLDSVAALSPQPAPGDNMIPPQPNLPEAELDQPVAPEDDEPTAAPETAAPEASQPAESDSPEPSESPDPVVPMPPEEERASTLDDSKFDASESEDKEEGTMEVDSSPHSEEPEVPDPFLVDEPEDSPSEEPEAAEEVAEEPTGLQVDIRPSLAAADEVSLVQPSDASEEPPPALPADVNKDVPPPPPQLVSDEEEEEAPELYLPGLTLPTMFLPIPNVRSLLFCSLNWWLARNRIIYYPYTSRRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JZP3</accession>
    <name>A0A2H3JZP3_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Aminopeptidase P N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WOLCODRAFT_100967</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD-104</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M24B family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH41637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JZP3"/>
    <dbReference type="STRING" id="742152.A0A2H3JZP3"/>
    <dbReference type="OMA" id="DSYFWYL"/>
    <dbReference type="OrthoDB" id="4215474at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01087">
        <property type="entry name" value="Prolidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007865">
        <property type="entry name" value="Aminopep_P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052433">
        <property type="entry name" value="X-Pro_dipept-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226:SF4">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05195">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01011">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminopeptidase P N-terminal" evidence="6">
        <location>
            <begin position="52"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PCH41637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="505" mass="55774" checksum="7D7A4D84A6EA876C" modified="2018-01-31" version="1">MLFRPTLRHTARTYRWQCTRTNSTFVKPSQFGQPLHPSHPHLVKDGELTPGIHADEYESRRRALMEGLPPNSLVICAAAKVKYMSGRTYKFRQGSDFLYLSGLLEPSAAFLLRSSPSTPRGYTYSIFHHFHTPSQALWDGPRTNDITLHDLFGADDVCPIDELPRALKKALRDADYVYVDQPQETRRTRKSGSAWKALLEHLAPASLADAKADLLSALSDLGARSGKIRPLAPEVGRLRAIKSPAEQKIMRAAADVSAHAHTKTMRFAQPGMSEHVLAAHFEYLCAREWSQRPAYVPVVASGPNALTIHYTANDQLIREDELVLIDAGCELDGYASDITRTFPASGRFTPAQAELYSAVLAAQKRLVSLSNASAGYSLYQLHTESVHLLADELRAIGFNLDRSSVGLMAELYPHFVGHPVGIDLHESSHFDRDAPLKPGMVITIEPGIYVPPRPHYPKHFHNIGIRIEDEVLVGETYPTVLSVNAPKEVADVEGACTGALGLEPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K1L2</accession>
    <name>A0A2H3K1L2_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Rab guanyl-nucleotide exchange factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WOLCODRAFT_163668</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VAM6/VPS39 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468124">
        <property type="protein sequence ID" value="PCH42287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K1L2"/>
    <dbReference type="STRING" id="742152.A0A2H3K1L2"/>
    <dbReference type="OMA" id="EEYCNQV"/>
    <dbReference type="OrthoDB" id="5325112at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034058">
        <property type="term" value="P:endosomal vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032914">
        <property type="entry name" value="Vam6/VPS39/TRAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019452">
        <property type="entry name" value="VPS39/TGF_beta_rcpt-assoc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019453">
        <property type="entry name" value="VPS39/TGFA1_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12894">
        <property type="entry name" value="CNH DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12894:SF49">
        <property type="entry name" value="VAM6_VPS39-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10366">
        <property type="entry name" value="Vps39_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a diacylglycerol + H2O = a monoacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15245"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. Lipase family. Class 3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB468157">
        <property type="protein sequence ID" value="PCH44548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K335"/>
    <dbReference type="STRING" id="742152.A0A2H3K335"/>
    <dbReference type="OMA" id="GCEVHDG"/>
    <dbReference type="OrthoDB" id="426718at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051218">
        <property type="entry name" value="Sec_MonoDiacylglyc_Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45856">
        <property type="entry name" value="ALPHA/BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45856:SF25">
        <property type="entry name" value="FUNGAL LIPASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013642043" evidence="5">
        <location>
            <begin position="24"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal lipase-type" evidence="6">
        <location>
            <begin position="106"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00043996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PCH44548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="307" mass="32132" checksum="45E8DCDFBF534D79" modified="2018-01-31" version="1">MSMSLSVLALGLALVSVAPSAHAVPATGLKARQSITAASASQIASYTPYTWYATAGYCSAAQTLAWDCGANCEANPDFEPVASGGDGDGTQYWFVGYDPTLDQVIVSHQGTDPEEILPLITDADIVKINLDSTLFPGLSTDIEVHEGFADAQAQTATDVLSAVQTTMSTYGTSNIVVTGHSLGAAIALLDAVYLPLHISDATFTFIGYGLPRVGNQAFANYVDAQPTSVTHINNEEDPIPICPGMSLGFVHPSGEVHIEDSGEWANCPGQDNPSTQCIVGDVPEIWDGDESDHDGPYNGIEMGCSAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K3D5</accession>
    <name>A0A2H3K3D5_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS19m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WOLCODRAFT_102786</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uS19 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468135">
        <property type="protein sequence ID" value="PCH42917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K3D5"/>
    <dbReference type="STRING" id="742152.A0A2H3K3D5"/>
    <dbReference type="OMA" id="EYVAFEV"/>
    <dbReference type="OrthoDB" id="2043at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.860.10:FF:000001">
        <property type="entry name" value="30S ribosomal protein S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.860.10">
        <property type="entry name" value="30s Ribosomal Protein S19, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00531">
        <property type="entry name" value="Ribosomal_uS19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002222">
        <property type="entry name" value="Ribosomal_uS19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020934">
        <property type="entry name" value="Ribosomal_uS19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023575">
        <property type="entry name" value="Ribosomal_uS19_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880">
        <property type="entry name" value="RIBOSOMAL PROTEIN S19P FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880:SF8">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US19M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00203">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002144">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00975">
        <property type="entry name" value="RIBOSOMALS19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54570">
        <property type="entry name" value="Ribosomal protein S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00323">
        <property type="entry name" value="RIBOSOMAL_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PCH42917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="93" mass="10478" checksum="47C8E08FAE8D1CFA" modified="2018-01-31" version="1">MLPTLVVQSGRSAWKGPFFVAFPNLRQALDNNIPIKTQARSCTILPNFVGLKFLVHNGKDYLPVSITQDMVGHKLGEFAATRKRFTYRATKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K620</accession>
    <name>A0A2H3K620_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_164796</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468146">
        <property type="protein sequence ID" value="PCH43877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K620"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="424"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="434"/>
            <end position="444"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH43877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="480" mass="51289" checksum="13068461DFEF74A1" modified="2018-01-31" version="1">MPDSKSQARFLIRAPKRLPVDVELAGGRMGFTMSPMWLRNLPDAARGPRELHRDASKDVAKMTTLFDLDLDAFCAIPARPVIVRKPLVLRPNGGNFSPSTGSSGSVVDRQELTDQSRASSLKQDALGTAIRADIEAFALDVDAAFAAPTNSRASSRAQAIRARLSASSASSPSLELACPSAGRSERPPKAQAIQSASDAAFKPPNFVSYDNSIDGNGSTATKCDLPSAPALIWQSCYHLDPAFHLSAMRIQMMPSTARMTLDEAYGIKKSTVAAVTHLASASVDATPVDSTVATTHRHGGTSVEAADATIISADIGDSSRIAGISREEPSYLPVVPVTDANLDQDSATIRGVQRTQARLVRSRADPGDESEFNAEKDALRSEVEISAAQHSPQSGIQTNASRQAGGDDVLEDIARMLWRRPARSQLQLADSSRHPSPSSTESGSDTVTPRAGAYDLPPPTRNDDVWLDITILLEWEARLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K6T5</accession>
    <name>A0A2H3K6T5_WOLCO</name>
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        <recommendedName>
            <fullName evidence="3 9">Histone H3</fullName>
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        <name evidence="12" type="ORF">WOLCODRAFT_164941</name>
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        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD-104</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="9">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the histone H3 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11426">
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    </dbReference>
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    </dbReference>
    <dbReference type="PRINTS" id="PR00622">
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HISTONE_H3_2"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
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        <location>
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            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010343"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
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                <person name="Ferreira P."/>
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                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
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                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
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                <person name="Young D."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH44257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K7S9</accession>
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    <protein>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
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                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
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                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
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                <person name="Sabat G."/>
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                <person name="Samejima M."/>
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                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468168">
        <property type="protein sequence ID" value="PCH45134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K7S9"/>
    <dbReference type="OMA" id="PMGNEST"/>
    <dbReference type="OrthoDB" id="2796352at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH45134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="174" mass="19026" checksum="099A708C4201FA1E" modified="2018-01-31" version="1">MSVLAPAIIAGFILSIVILLSILSTACIILYRRYRSQGSVPIFLHSSPDLEKAPKQKTPPKRKKLLRKAPPPLPEDAFDPHADVFGPIDFGPEEHNHSLSTLNVTISPSAPRMFKVETEGGGSIGVEVRVTPPTPNTTRAPLPATMSGYLRRMRFAAISIPATQSVTESKWWSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IU37</accession>
    <name>A0A2H3IU37_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_160111</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH33496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3IU37"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH33496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="178" mass="18568" checksum="935D232B41049D5A" modified="2018-01-31" version="1">MTFHPPQRLCLFAFQEVCSNAVNATSPPVIDHACHVLVTLAVVDLARPQVRQVMGPVQSPGPTRTYLLPVIRPSSDAPTLWRGACPVCLRTSGETLALTLYEPDVLAVDANVAEPSLDAVPELTTGAVVEAAADVVVDSKGKTVSDGNPETDVCAVGSDDGVMVVLPGKRVLSDDGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IUE5</accession>
    <name>A0A2H3IUE5_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Rab-type small GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WOLCODRAFT_111188</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Protein transport. Probably involved in vesicular traffic.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH33045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3IUE5"/>
    <dbReference type="STRING" id="742152.A0A2H3IUE5"/>
    <dbReference type="OMA" id="ENIRTWF"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01867">
        <property type="entry name" value="Rab8_Rab10_Rab13_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000363">
        <property type="entry name" value="Secretion related GTPase srgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050305">
        <property type="entry name" value="Small_GTPase_Rab"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47980">
        <property type="entry name" value="LD44762P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0636">Prenylation</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PCH33045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="209" mass="23040" checksum="EEF139928C8FCB5E" modified="2018-01-31" version="1">MPPPHYDFLIKLLLIGDSGVGKSCLLLRFCDDAWTPSFITTIGIDFKIRTIELDGKRIKLQIWDTAGQERFRTITTAYYRGAMGILLVYDVTDERSFNNIRTWHANIEQHASEGVNKILIGNKSDWTDKRAVTEEQGRELANELGIKFMETSAKINEGVEEAFFTLARDIKARLIDSQPEAAGAANGATGTDGAVKVNQPANQGAGGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IUJ5</accession>
    <name>A0A2H3IUJ5_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AP-2 complex subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WOLCODRAFT_135237</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <location evidence="1">Coated pit</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH33642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3IUJ5"/>
    <dbReference type="STRING" id="742152.A0A2H3IUJ5"/>
    <dbReference type="OMA" id="PVLMHRY"/>
    <dbReference type="OrthoDB" id="28053at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030122">
        <property type="term" value="C:AP-2 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035615">
        <property type="term" value="F:clathrin adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000020">
        <property type="entry name" value="AP-2 complex subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050840">
        <property type="entry name" value="Adaptor_Complx_Large_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017104">
        <property type="entry name" value="AP2_complex_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003164">
        <property type="entry name" value="Clathrin_a-adaptin_app_sub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008152">
        <property type="entry name" value="Clathrin_a/b/g-adaptin_app_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009028">
        <property type="entry name" value="Coatomer/calthrin_app_sub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22780">
        <property type="entry name" value="ADAPTIN, ALPHA/GAMMA/EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02296">
        <property type="entry name" value="Alpha_adaptin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02883">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037091">
        <property type="entry name" value="AP2_complex_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00809">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55711">
        <property type="entry name" value="Subdomain of clathrin and coatomer appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0168">Coated pit</keyword>
    <keyword evidence="3 7" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin adaptor alpha/beta/gamma-adaptin appendage Ig-like subdomain" evidence="10">
        <location>
            <begin position="687"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="623"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="626"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="6"/>
            <end position="7"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="51"/>
            <end position="55"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR037091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR037091-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PCH33642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="928" mass="104102" checksum="B31079258AD154DE" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IUX9</accession>
    <name>A0A2H3IUX9_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Eukaryotic translation initiation factor 4E</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF-4F 25 kDa subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">mRNA cap-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WOLCODRAFT_135330</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the eukaryotic initiation factor 4E family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH33800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3IUX9"/>
    <dbReference type="STRING" id="742152.A0A2H3IUX9"/>
    <dbReference type="OMA" id="MSARANF"/>
    <dbReference type="OrthoDB" id="590761at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.760.10:FF:000011">
        <property type="entry name" value="Eukaryotic translation initiation factor 4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001040">
        <property type="entry name" value="TIF_eIF_4E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960:SF8">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01652">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0810">Translation regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PCH33800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="302" mass="33445" checksum="2ADC1F738A96FBC6" modified="2018-01-31" version="1">MTSTASSLPVSALQASQAAVNAALAENEIKEKENGKANGDESLEPGEIQEVDMQAQADAIRTVFSDPTNFNVKHPLYSPWTLWFDSPATKGRNLPQTPMSSFPQTPLPQTPGAAAAQGWMEDIKRVISFDSVEEFWGMYNNIVPPSQLPQKANYYLFKEGIIPAWEDEANKNGGKWSIQLPKDKNRSNVDKMWLYTMLAAIGETFDPQLSESSPQSLITGVIVSTRPQFYRLSIWTRAAPTGAGEDEKLRERIEAIGRHFKISVLGYSESQKLAGPLATEVEFLSHKDSEKKGKAAKKPWVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IV15</accession>
    <name>A0A2H3IV15_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Beta-lactamase/transpeptidase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_94263</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the beta-lactamase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH33822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3IV15"/>
    <dbReference type="STRING" id="742152.A0A2H3IV15"/>
    <dbReference type="OMA" id="NSRAMYS"/>
    <dbReference type="OrthoDB" id="428260at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051478">
        <property type="entry name" value="Beta-lactamase-like_AB/R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22935:SF95">
        <property type="entry name" value="BETA-LACTAMASE-LIKE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22935">
        <property type="entry name" value="PENICILLIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase-related" evidence="2">
        <location>
            <begin position="82"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH33822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="602" mass="65680" checksum="8563D607436CF846" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IXA7</accession>
    <name>A0A2H3IXA7_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_165707</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467832">
        <property type="protein sequence ID" value="PCH34630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3IXA7"/>
    <dbReference type="STRING" id="742152.A0A2H3IXA7"/>
    <dbReference type="OMA" id="WWQVVET"/>
    <dbReference type="OrthoDB" id="1933717at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43975:SF2">
        <property type="entry name" value="EG:BACR7A4.14 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43975">
        <property type="entry name" value="ZGC:101858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH34630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="289" mass="31442" checksum="A11C3491E71C322B" modified="2018-01-31" version="1">MLDPTGVDFVPTARHDTYAAIDPAKANLYGKVVVITGASKGIGHSIAVALAQAGVSALVLIARSDMSAVKVACEAAQRPGQSLRVLTISASVSDTHQVVEAAQKVREELGRVDVLVNNAGYMEKYGLIAEQDPSEWWKVWSVNLQGTYEVTRAFLPLLTECGGDKTIVNMTSIGGHFQGPRYSAYQVSKLALMRFTELIMAEYTEQGVLAYSVHPGSIATDMAATMPEELMGVLVDSPEVAAHTIVWLVKERREWLGGRYVSCQWDVDELSAKKEEIITGDKLKVRMVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IXF9</accession>
    <name>A0A2H3IXF9_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WOLCODRAFT_37793</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB467832">
        <property type="protein sequence ID" value="PCH34680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3IXF9"/>
    <dbReference type="STRING" id="742152.A0A2H3IXF9"/>
    <dbReference type="OMA" id="MDATVLY"/>
    <dbReference type="OrthoDB" id="440755at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF9">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="5"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PCH34680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="114" mass="12040" checksum="D02FDE4BD2F9FFDA" modified="2018-01-31" version="1" fragment="single">RRYILLAVFCCAQFLDSFNNSALFSAIPSLVNSLGISESESTWIISAFQLTFASFLLISGRISDVYNPKVAFIGGVAALGFISIGAGFVNDQISLIVLRALSGIAASMTIPSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IY95</accession>
    <name>A0A2H3IY95_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_56367</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467837">
        <property type="protein sequence ID" value="PCH34936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3IY95"/>
    <dbReference type="STRING" id="742152.A0A2H3IY95"/>
    <dbReference type="OMA" id="DIACAFW"/>
    <dbReference type="OrthoDB" id="3251205at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040521">
        <property type="entry name" value="KDZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096:SF1">
        <property type="entry name" value="CXC1-LIKE CYSTEINE CLUSTER ASSOCIATED WITH KDZ TRANSPOSASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096">
        <property type="entry name" value="CXC2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18758">
        <property type="entry name" value="KDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH34936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="290" mass="33081" checksum="D8A592D52F65C2B4" modified="2018-01-31" version="1" fragment="single">MKYLLAIVNKLLEVYGPDIMVGYDIACAFGRTLAKSSLGPTAQKLRYAGVVPAFHGHSHNRGCQVHWHPMYLEGVGKEDFEGCERCFSESNALASGTRLASHFHRQQAIEEFFTFWGEQKHIESGTFIFSNYKQALGIIEQDSKILAALSMELKVGPADYEAYLQQEKEFLRSLKTEPLEVVRKADYMDALRRLEEAGRCRAATEAEFHNLDYNIIHRGYTRKEIAHVKAQQTSAITRWLAVDEECRLIEEELDIDMRWVPGSAAYEAGVAELAKRDYRRALDDLERLIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IYL9</accession>
    <name>A0A2H3IYL9_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidyl-prolyl cis-trans isomerase</fullName>
            <ecNumber evidence="6">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WOLCODRAFT_79617</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PpiC/parvulin rotamase family. PIN4 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="6"/>
    <dbReference type="EMBL" id="KB467843">
        <property type="protein sequence ID" value="PCH35056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3IYL9"/>
    <dbReference type="STRING" id="742152.A0A2H3IYL9"/>
    <dbReference type="OMA" id="NAINVRH"/>
    <dbReference type="OrthoDB" id="1911748at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043323">
        <property type="entry name" value="PIN4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000297">
        <property type="entry name" value="PPIase_PpiC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45995">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13616">
        <property type="entry name" value="Rotamase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50198">
        <property type="entry name" value="PPIC_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PpiC" evidence="8">
        <location>
            <begin position="43"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PCH35056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="138" mass="14726" checksum="3F707C5731636024" modified="2018-01-31" version="1">MAKKANASADKKPADKKAGKGAAKTSEAASDSKSKGKGALKPATAVNVRHILCEKHSKATEALQKIQEGQRFDKVAQEYSEDKAKAGGSLGWMVRGSMVGPFQEAAFALEPSNVDKPILSPLVKTNFGYHIIMVEGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IZQ1</accession>
    <name>A0A2H3IZQ1_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acyl-CoA N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WOLCODRAFT_134852</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acetyltransferase family. GNAT subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH33013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3IZQ1"/>
    <dbReference type="OMA" id="WHVPRYH"/>
    <dbReference type="OrthoDB" id="5043642at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039135">
        <property type="entry name" value="NAT9-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13256:SF16">
        <property type="entry name" value="ALPHA_BETA-TUBULIN-N-ACETYLTRANSFERASE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13256">
        <property type="entry name" value="N-ACETYLTRANSFERASE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="37"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="742152.A0A2H3J181"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="395"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="416"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH35445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="725" mass="82974" checksum="A29E722DFAA8EB87" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J1D7</accession>
    <name>A0A2H3J1D7_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA2/NAM7 helicase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_145835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467854">
        <property type="protein sequence ID" value="PCH35505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J1D7"/>
    <dbReference type="STRING" id="742152.A0A2H3J1D7"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF495">
        <property type="entry name" value="HELICASE SENATAXIN ISOFORM X1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="1">
        <location>
            <begin position="406"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH35505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="785" mass="88442" checksum="A65ACCD9090AD3E6" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J1S5</accession>
    <name>A0A2H3J1S5_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_135292</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467831">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="742152.A0A2H3J1S5"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="385"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH33743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="426" mass="48332" checksum="22836AAAEF2CB2D7" modified="2018-01-31" version="1">MPASAVASTRGARCLSAAQVAHDARRFAEWSFHQAFIEDVDWSDIPERFMPWIQNIFAVDGQLPKMWKDQKYLLKQSVQFQKFMFNVCSKDPDLFAKEGTNMEDETTEKFHDNITTVINIWNRLHDLRKSGRHVTYSDYSGIFQQLCSVAIVQSDLRPNCMIALPAPIEPIPVTSSLSDSAKKLKCSASIFIPSKHIGELSSSAKSPYKQLNAHPSIMEKRSGIKPPFWLQVTPLWNPIPPSSFEFASCFMHGSRASQEEARRLTKMATTAALRQLRSLCISSPVYGLAWHETRVTADIAWCTDFSNKFPKIHSTSYKNAATKSWDISKQKDILRVFLILRNIDRWTVNQFHDEICRGVGTMRDRVMAGEEKITPWRVATGAVSSRKRACPSSDAEDDVEAADRPKRKRSAAFLLQSGRGRKRRAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J208</accession>
    <name>A0A2H3J208_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA-(apurinic or apyrimidinic site) endonuclease</fullName>
            <ecNumber evidence="12">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">WOLCODRAFT_126947</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">MD-104</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9 12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="9 12">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="9 12">Probably binds two magnesium or manganese ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the DNA repair enzymes AP/ExoA family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="12"/>
    <dbReference type="EMBL" id="KB467876">
        <property type="protein sequence ID" value="PCH36272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J208"/>
    <dbReference type="STRING" id="742152.A0A2H3J208"/>
    <dbReference type="OMA" id="SFWICPR"/>
    <dbReference type="OrthoDB" id="391817at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008311">
        <property type="term" value="F:double-stranded DNA 3'-5' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09088">
        <property type="entry name" value="Ape2-like_AP-endo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004808">
        <property type="entry name" value="AP_endonuc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
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        <property type="entry name" value="AP ENDONUCLEASE"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR22748:SF4">
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn_ribbon_GRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="AP_NUCLEASE_F1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZF_GRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 9 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 9 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GRF-type" evidence="14">
        <location>
            <begin position="542"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="360"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="366"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="475"/>
            <end position="489"/>
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    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="8">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="298"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="297"/>
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        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
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    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="298"/>
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        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="10">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="10">
        <location>
            <position position="272"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA substrate" evidence="10">
        <location>
            <position position="298"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-1"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-2"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-3"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PCH36272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="617" mass="68754" checksum="E584F7A38B3685CB" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J2T6</accession>
    <name>A0A2H3J2T6_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WOLCODRAFT_108843</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD-104</strain>
        </source>
    </reference>
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        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
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            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="MFS quinate transporter QutD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
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    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
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    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
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    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
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        <property type="entry name" value="Sugar_transporter_CS"/>
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        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF14">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="SUGRTRNSPORT"/>
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        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="64"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="321"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="362"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="389"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="421"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="486"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="63"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH36570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="562" mass="59925" checksum="E3E91042AE4BD0EB" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J392</accession>
    <name>A0A2H3J392_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribonuclease H-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WOLCODRAFT_82537</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467887">
        <property type="protein sequence ID" value="PCH36720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="742152.A0A2H3J392"/>
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    <dbReference type="OrthoDB" id="3253957at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="P:DNA integration"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000032">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056924">
        <property type="entry name" value="SH3_Tf2-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24626">
        <property type="entry name" value="SH3_Tf2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="3">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="2">
        <location>
            <begin position="274"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PCH36720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="330" mass="38376" checksum="3394E7BE655184EA" modified="2018-01-31" version="1">MVIVDRLTKRARFIPTTDNLSTKELATILYSRIFPIHGLPKQIVSDRGTQFASELFREWCETLNVQRSMTTAYHPQADGQTERVNQTLEQYLRCYIEVVQKDNWSQFLPTAEFAYNNAASETTKNSPFYVELGRHPNAGPTDLRPTTNADLNQIAQARWAAQDQAKAAMKIAAERWSWYYDQGRKAAPFDVGDKVLVDVRKWQDTERSLSPRYIGPFKIIEKLSPVTFKLHMDSQYRAYHPVFHASKLVLYKEATIQNKPPPQPERNEEGEETWEVENILDHRRRGSKMEYRIRWKGFTVSDDSWIPEMELNSAAELLEEYKLSQPDLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J3H6</accession>
    <name>A0A2H3J3H6_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ferredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WOLCODRAFT_167087</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD-104</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the adrenodoxin/putidaredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467887">
        <property type="protein sequence ID" value="PCH36726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J3H6"/>
    <dbReference type="STRING" id="742152.A0A2H3J3H6"/>
    <dbReference type="OMA" id="YWIHALS"/>
    <dbReference type="OrthoDB" id="268593at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140647">
        <property type="term" value="P:P450-containing electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001055">
        <property type="entry name" value="Adrenodoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018298">
        <property type="entry name" value="Adrenodoxin_Fe-S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23426:SF65">
        <property type="entry name" value="FERREDOXIN-2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23426">
        <property type="entry name" value="FERREDOXIN/ADRENODOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00355">
        <property type="entry name" value="ADRENODOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00814">
        <property type="entry name" value="ADX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="7">
        <location>
            <begin position="78"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PCH36726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="213" mass="23195" checksum="165EE715CA912834" modified="2018-01-31" version="1">MFSHLARGSKAGCLHARLSSACRRPRSVRTFSSPAFSSVSSHRHQPPLCRPGLIETRSAYHSSAVCNHGSITRPAPGTGIKLHFKDSKGSHLKTVEVNEGDDILSIAHEHDIDLEGKHLFEGRCQLADLCDPGACEGSVACSTCHVILSPEHYDLLPEPEDDENDMLDMAFGLTDTSRLGCQVKITRELDGMTATLPSATRNMFVDGKKPTHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J5P0</accession>
    <name>A0A2H3J5P0_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_28875</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467898">
        <property type="protein sequence ID" value="PCH36985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J5P0"/>
    <dbReference type="STRING" id="742152.A0A2H3J5P0"/>
    <dbReference type="OMA" id="GEMAWNI"/>
    <dbReference type="OrthoDB" id="2801156at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH36985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="223" mass="24528" checksum="C84E7F043225D560" modified="2018-01-31" version="1">MPSLSFTDRLSRTGELYLLAKLPDERRSGLYLATMPKSRGTDWPATGSSSGDAPDGQVEVVVKFTTKYNADAHRVLADAGLAPALHACIPVCGRLHMVVMERVHGEMAWNIQQRGELLPYTVYKDVKAAIDLLHQHNLVFGDLRAPNIMCAPGASSSGPDEGSHAMLIDFDWVGTHGSARYPAILNDSLPVWAFGMQRCAIMYKEHDLAMLEKFRELCQANTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J621</accession>
    <name>A0A2H3J621_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_148649</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH37692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J621"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH37692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="152" mass="15898" checksum="81F39D19FD818D28" modified="2018-01-31" version="1">MAEAGTLGHLHGETHTAMKGRLLAGMRLCVLRPVSGVWLAGAWPRRGRGYAHALTPTNAENAPSQNSNRATHNAHVTPKAECKTSARDRWLKALLPLYTPASMAAPDPSSALTPSVEAHRPTSSLPTAAARVVICADCSLVDSGCHTAGAAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J646</accession>
    <name>A0A2H3J646_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Arginase</fullName>
            <ecNumber evidence="2 11">3.5.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WOLCODRAFT_95706</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-arginine + H2O = urea + L-ornithine</text>
            <dbReference type="Rhea" id="RHEA:20569"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="EC" id="3.5.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8 11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="8 11">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nitrogen metabolism; urea cycle; L-ornithine and urea from L-arginine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the arginase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.3.1" evidence="2 11"/>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH37722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J646"/>
    <dbReference type="STRING" id="742152.A0A2H3J646"/>
    <dbReference type="OMA" id="YKEFRYA"/>
    <dbReference type="OrthoDB" id="9992747at2759"/>
    <dbReference type="UniPathway" id="UPA00158">
        <property type="reaction ID" value="UER00270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004053">
        <property type="term" value="F:arginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006525">
        <property type="term" value="P:arginine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000050">
        <property type="term" value="P:urea cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd09989">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.10:FF:000009">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.10">
        <property type="entry name" value="Ureohydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014033">
        <property type="entry name" value="Arginase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020855">
        <property type="entry name" value="Ureohydrolase_Mn_BS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01229">
        <property type="entry name" value="rocF_arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43782">
        <property type="entry name" value="ARGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43782:SF3">
        <property type="entry name" value="ARGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036979">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00116">
        <property type="entry name" value="ARGINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01053">
        <property type="entry name" value="ARGINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0056">Arginine metabolism</keyword>
    <keyword evidence="6 10 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8 11" id="KW-0464">Manganese</keyword>
    <keyword evidence="5 8 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR036979-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PCH37722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="315" mass="33958" checksum="7533242EF484097C" modified="2018-01-31" version="1">MSSESSVSRFLPNPKTVAIVGCPFRGGQAKLGVDHGPIHLVEAGLPQQLEGLGWKVEFDGHHQFQKIDTENDPPIGKLKNPRLVSRVCEAVAKVVGGHAKKGQLPLTLGGDHSLAMGTISGTLEQYPDACVIWVDAHADINTAETTDSGNIHGMPVSFLLGLGPKIPEFGWVQPRLDPSRIVYIGLRDVDAGEKRILREQGIRAFSMHEVDKHGIGRVVEMALDHVNPRRDRPVHLSFDVDALDPSVAPSTGTPVRGGLTFREGHYICEAIYETGCLVALDIMEVNPSLAEPEEVKQTVAVGCSLARSALGETLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J6E4</accession>
    <name>A0A2H3J6E4_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Mitochondrial carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WOLCODRAFT_135869</name>
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        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
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        <lineage>
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            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </feature>
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            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
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                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
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                <person name="Schmutz J."/>
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                <person name="St John F."/>
                <person name="Stenlid J."/>
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                <person name="Tsang A."/>
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                <person name="Eastwood D.C."/>
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            </authorList>
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    </reference>
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    </evidence>
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</entry>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Blanchette R.A."/>
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                <person name="Kumar T.K.A."/>
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                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
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                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
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                <person name="Martinez A.T."/>
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                <person name="Ferreira P."/>
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                <person name="Gaskell J."/>
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                <person name="Heitman J."/>
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                <person name="Hori C."/>
                <person name="Igarashi K."/>
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                <person name="Kallen N."/>
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        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="67" mass="7269" checksum="F12A3780747758EE" modified="2018-01-31" version="1">MHTRTASCAPRSHHRCTSTAHAPSPLSAAVPVCHRHSEAHATPVNHNLPQCCHCGWRGDHAPTCPFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J9M9</accession>
    <name>A0A2H3J9M9_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_158437</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467943">
        <property type="protein sequence ID" value="PCH38906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J9M9"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH38906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="91" mass="10208" checksum="BA9D5B3048AFB2DE" modified="2018-01-31" version="1">MAHNLEYIQGPHQPHAEEVEAHTPDLFMELFQDDFGRLSVQDSIHAPARTASVVQGTALNSRYSKEHSSSHETRATRCKEPVNSVPRFSPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J9X0</accession>
    <name>A0A2H3J9X0_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_146847</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467954">
        <property type="protein sequence ID" value="PCH39062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J9X0"/>
    <dbReference type="STRING" id="742152.A0A2H3J9X0"/>
    <dbReference type="OMA" id="HEPPREK"/>
    <dbReference type="OrthoDB" id="1937642at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH39062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="476" mass="52098" checksum="A4D43E914483CC75" modified="2018-01-31" version="1">MAPSLRSYLSGLTSRSNGSIEHQIDQPFNQVKAQWRNPNDILSIVQLIGGDTVQTALAASTSPSYLTPVAFSFGWVAYAFSTISTVFGDGTLMPSPDCNAILVNARSGYQRDIKSWVLGRIVRDHEPPREKKPSLTITFYRAVRDKPVGIPDRDMIYFFGVAVIIVQFVIACIPGVLDRNWVPLIITFAGTILVQATGAIRQWSREKWNGGQVEGEQTVCITQGNGSRSVQVITTQSGGHNLEHMAAGPLPDVKSRATTVATIVLAVLWVVHLITVESLSSDAWYSVAIGALGMLQNTIAAGAKWSPSAFGFHWEMVEIVSKPKVFKTLQEAEKIKPGVGLALLPVFFPGELRNDEMRWKEEKLRQYKANDAAQIRPQTAMTRDTDSPTALSVDITAQHTPGQPYPEIWHPISWLYPPAPRLRGVEEGATASAVELGRYSPISFNAALLLPSLSVEEPNEVRQVSVGAVFKLQAVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JB30</accession>
    <name>A0A2H3JB30_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_159009</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467998">
        <property type="protein sequence ID" value="PCH39440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JB30"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH39440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="167" mass="17397" checksum="1BE6C52BA393475B" modified="2018-01-31" version="1">MSSSVRFAHRAAVDTTQAGGVRLEIGWNKCLILTDPPATSHAAGHAGGRSRSAWTAAAANLGASVGPTLPQLVSDATTWRLASLRAFEARGPGLSAQHSSRRTLRTLSSIRVLNGSTVHPDIGVDINGRRFPLEHLLFVSRCGYMAAAANGGHNMPYSPSMGALAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JBG2</accession>
    <name>A0A2H3JBG2_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_158461</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467943">
        <property type="protein sequence ID" value="PCH38925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH38925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="306" mass="33979" checksum="32A29D96EA48593D" modified="2018-01-31" version="1">MDDFDYSSPIQSLLYEDPDGNRGSPLSKGDLKMAEELKKEVKERAFLAVSLLDMFGYEEDEDGIERVEKEAIDRQVCHDLESFYWLLIWVVLRHTKHSHKQKARAFNILFDVNTEATAQTMKIVFVARKSLSVEGNRPLSWLLDKLRRLVLAANSDIIESGGIAQGSLTYESMLSVFNEALAMDCWPADDKAIPFPPPTLRQNKPSDGTLTLGNGHKQKGSVRASGQPELGKIPELPTHNGAYDGTNKGPDVPCPRSQAPIAGSSGAAARPSASGVASTRCRKRNWREILPARGQHERRAKRARQN</sequence>
</entry>
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    <accession>A0A2H3JBJ0</accession>
    <name>A0A2H3JBJ0_WOLCO</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
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        <lineage>
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            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JBJ0"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="204"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH39622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="204" mass="22055" checksum="4154E1AAE5639DF7" modified="2018-01-31" version="1">MRHHMPGCPRPRAAAVPARCAAPPPRTASERSPAGAMRAGGRLRFCALRRASAATTTRHAHCVLVSPVRLKRGQGLPRAYTRQHTRTSNAQARRREHHPSTRPADARRVASAAATDERRGRGDSGAGQGRRQDETSTASQIANTASQIANTTRNNIHAPTGHIHLRSPTKSAPRRRSRPIAVREPRSVSARVAHAEDVGSSCRP</sequence>
</entry>
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        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
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                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
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                <person name="Martin F."/>
                <person name="Cullen D."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH36199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="159" mass="17384" checksum="E28822266945FF55" modified="2018-01-31" version="1" fragment="single">SGYSALSPDGRTIAVHNLIDGLHLYRTGVSGEQRPRRHFKFDVPPRTKHALRLAFLHQGQALVCGTTTGNVCIWETTTGEFYQQLAHDNDIVQTVAAYHRGDLSFVATASTGKGNNICVKIWRAKRAAGSPQDATETLFVATLLALEACTTSLQLIPHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JC05</accession>
    <name>A0A2H3JC05_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA mismatch repair proteins mutS family domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WOLCODRAFT_147580</name>
    </gene>
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        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
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        <property type="protein sequence ID" value="PCH33487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043504">
        <property type="term" value="P:mitochondrial DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017261">
        <property type="entry name" value="DNA_mismatch_repair_MutS/MSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
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        </source>
    </evidence>
    <sequence length="118" mass="13005" checksum="6FE3D06FA578CCD9" modified="2018-01-31" version="1">MVPLAGPREQPWTTDEWSYTSTLFMVAEYATEPKGSKLKHSKHSNGTIPVNLPEPEEECPEQLYEIFARSDPKSTSESTLIRHVAVPSLSKEADAPAQSASQMKVVHLLNLGEGADRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JDA1</accession>
    <name>A0A2H3JDA1_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WOLCODRAFT_142971</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CFA/CMAS family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468053">
        <property type="protein sequence ID" value="PCH40220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JDA1"/>
    <dbReference type="STRING" id="742152.A0A2H3JDA1"/>
    <dbReference type="OMA" id="WGGLAEF"/>
    <dbReference type="OrthoDB" id="8300214at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050723">
        <property type="entry name" value="CFA/CMAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003333">
        <property type="entry name" value="CMAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43667">
        <property type="entry name" value="CYCLOPROPANE-FATTY-ACYL-PHOSPHOLIPID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43667:SF2">
        <property type="entry name" value="FATTY ACID C-METHYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02353">
        <property type="entry name" value="CMAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003085">
        <property type="entry name" value="CMAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="2 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="170"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="170"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="198"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PCH40220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="530" mass="58601" checksum="61C1A0A3200EAB70" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JDY4</accession>
    <name>A0A2H3JDY4_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">alpha,alpha-trehalase</fullName>
            <ecNumber evidence="2">3.2.1.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Alpha,alpha-trehalase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Alpha,alpha-trehalose glucohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WOLCODRAFT_98854</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 37 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.28" evidence="2"/>
    <dbReference type="EMBL" id="KB468053">
        <property type="protein sequence ID" value="PCH40416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JDY4"/>
    <dbReference type="STRING" id="742152.A0A2H3JDY4"/>
    <dbReference type="OMA" id="DARNAWH"/>
    <dbReference type="OrthoDB" id="3542292at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004555">
        <property type="term" value="F:alpha,alpha-trehalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005993">
        <property type="term" value="P:trehalose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001661">
        <property type="entry name" value="Glyco_hydro_37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018232">
        <property type="entry name" value="Glyco_hydro_37_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403:SF1">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01204">
        <property type="entry name" value="Trehalase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00928">
        <property type="entry name" value="TREHALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PCH40416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="324" mass="34551" checksum="FA4E95BE41FE3AF4" modified="2018-01-31" version="1">MYTSTGNSSGAATHTAFADSLREAVLDVCWDSEKLAFYDFNLTSRNHSTVFSAATFYPLWNDIIPAELLESADNAFGYLSSVNLVLNRYNGSFPVTFLETGLQWDAPNAWPPHQFIILEALQALPANVTVGSLPTSPSNASTYALVPAGQLGIAEGTLPGQPILRTGANATKVGPAADINRLSGTVVNGGNATSGEGWARALQRELANRYFASALCSWHATGGSIPGILPRLSDAELNVTQSVNNTGNMFEKFKIIDVDSFGSGGEYTVQAGFGWTNGVVLWMASNYGDVLVAPNFPALLAITNAHRLPKALQASQSLSRDGWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JEY0</accession>
    <name>A0A2H3JEY0_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Terpenoid synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_136651</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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            <position position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH40095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="309" mass="34096" checksum="FC6A63621610890C" modified="2018-01-31" version="1" fragment="single">MVSVAITRRLGVRSTSFPVVLARRAPTVGRRLTTSPHPRAHQEGGTQDPVAYCTELVRKRDYDSYLTSQFWPRNLRDDFLVLRAFYVELATVQEAVSNPTLGKMRTQFWRDAVKGMADGRPPRHPIALAVNETYHKASLPGYHFKRIIDARDAELHTPTHLTLESLTSHVESTSSSFAYLLLSLLSLSSSSTLSHAASHLGISQGIATLLRALPYHASQGRMVIPAEITARHGVSQEDVFRRGGTANGIQDAVFEFATVANDNLMTSLEMFKQDETGGKASARALPVFLAGVPTRLYLECLEAVNFDAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JF32</accession>
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        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR019049">
        <property type="entry name" value="Nucleoporin_prot_Ndc1/Nup"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09531">
        <property type="entry name" value="Ndc1_Nup"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH40816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="450" mass="51472" checksum="7925FE9EB76E7263" modified="2018-01-31" version="1">MADRPYPPGAWQVQLGPVSDFFFSPLSSNSFYILGNVVHGIIFGIMRSALPLTIALPFVRRLLYPFTAHFLRGPWTLVLPIRQWSIIFQTLHIGLTTVACWNNVFDGPFLLNEWDCAYSNRFDDPIPILLSGVASSNKWMQYCAYDELSVRIEGNSNSARACRLRLFAGIKHNHSLWQFLVQATLQLLREDREILLRRGMPISQSIDTPNVGELSDSSAVRLLKMLRELKKERLYVALLGPYTHWIRPLVHKKVEMALPNRYTDIKAVTVLCTLMRDSREQELQGVIQRDMSAIIEVMVLFLLEIEAFRNEINENPRSTAEAELRSGLKRLPVEESIGLARQVIFGFEMEFANKMLDQLSITYKEKLQQIVAMLQRNSMLSAETIRNLKETVIRKTYQVIAKSVRVLVESTVPAERPTIPTLPAFKPANNNAQAAFKIFHVSPTKRQKML</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JFH0</accession>
    <name>A0A2H3JFH0_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WOLCODRAFT_158207</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type III membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OST4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467931">
        <property type="protein sequence ID" value="PCH37489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Oligosaccaryltransferase"/>
    </dbReference>
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        <property type="entry name" value="OST4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036330">
        <property type="entry name" value="Ost4p_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48164">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48164:SF1">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ost4"/>
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    </dbReference>
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        <property type="entry name" value="Oligosaccharyltransferase subunit ost4p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
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        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004643"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PCH37489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="64" mass="7085" checksum="F6B07AE8513895EA" modified="2018-01-31" version="1">MRQIQTNKHSSGDHDFEHKMITHMELYNLANTLGMLAMVTVVAYHFVAVNAKHVSGQNGNTASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JFJ3</accession>
    <name>A0A2H3JFJ3_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WOLCODRAFT_140908</name>
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    <organism evidence="13 14">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD-104</strain>
        </source>
    </reference>
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        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="VPS15-like_hel"/>
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    </dbReference>
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        <property type="match status" value="2"/>
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        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PROTEIN_KINASE_ST"/>
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        <property type="entry name" value="WD_REPEATS_1"/>
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        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 10" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="25"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="9">
        <location>
            <begin position="497"/>
            <end position="528"/>
        </location>
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    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="1164"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="824"/>
            <end position="853"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="987"/>
            <end position="1043"/>
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            <begin position="1064"/>
            <end position="1104"/>
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            <begin position="1459"/>
            <end position="1483"/>
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        <location>
            <begin position="995"/>
            <end position="1004"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1019"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1064"/>
            <end position="1073"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PCH37519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="1643" mass="181414" checksum="0F255CB233460309" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JFJ9</accession>
    <name>A0A2H3JFJ9_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Palmitoyltransferase</fullName>
            <ecNumber evidence="10">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WOLCODRAFT_68159</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="10"/>
    <dbReference type="EMBL" id="KB468053">
        <property type="protein sequence ID" value="PCH40325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JFJ9"/>
    <dbReference type="STRING" id="742152.A0A2H3JFJ9"/>
    <dbReference type="OMA" id="WYHYLPL"/>
    <dbReference type="OrthoDB" id="9909019at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12246">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="189"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="12">
        <location>
            <begin position="142"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PCH40325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="374" mass="42334" checksum="0728BACC564598F0" modified="2018-01-31" version="1">MSTARKGPLLAPPADPPPRPVRWDDDEDDDVEPPKRKAWYSYLPLLAAVILMLLPHPSLLIVLVNYHLLVLNSPAQFLTHLAITYTLTFLAFSSLILILARDPGPVDADKAPETTAGSLDDMDFMQALLATEDLEPQTQAPGRWCKKCAASKPERTHHCSTCGRCVLKMDHHCFWLGDRCIGHRTYSAFIHLLTCITLLSVYVAALCVEAVYFAFTNPLAIDENTPLHDIYLAFYGIIMTLVFGSFWIYHLYLVTTNQTTLEHLSPYLLLRHLPPLPEQTDQSHFLSNPPLEHELSYAQRRVVREAHFHLRIYDVGWRKNWGQVVGWDRPWGWLHRLTVGGGGKGDGRTFPHNPRADDLLARLAAEIVAVDKHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JGF3</accession>
    <name>A0A2H3JGF3_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">GPI mannosyltransferase 1</fullName>
            <ecNumber evidence="13">2.4.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">GPI mannosyltransferase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">WOLCODRAFT_65228</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN-acyl-PI during GPI precursor assembly. Required for cell wall integrity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Endoplasmic reticulum membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the PIGM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="13"/>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH37839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JGF3"/>
    <dbReference type="STRING" id="742152.A0A2H3JGF3"/>
    <dbReference type="OMA" id="MLWFIGQ"/>
    <dbReference type="OrthoDB" id="1741594at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990529">
        <property type="term" value="C:glycosylphosphatidylinositol-mannosyltransferase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051751">
        <property type="term" value="F:alpha-1,4-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004376">
        <property type="term" value="F:GPI mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007704">
        <property type="entry name" value="PIG-M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12886:SF0">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12886">
        <property type="entry name" value="PIG-M MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05007">
        <property type="entry name" value="Mannosyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 13" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="254"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="332"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="357"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="400"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="437"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PCH37839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="456" mass="52206" checksum="4E12F1E3712E2C8A" modified="2018-01-31" version="1">MFLTISLSQLVSFKNVVLISGVLRIALILYSEWHDAHSVVKYTDVDYRVFSDAAYFIANPSLSNRAQGPLGELLRVGEYLQSPYSRATYRYTPLLAVLLTPNEWLHPSFGKYLFAACDIFAGVLMYKLLISVILPHADKTAREDNTTHHNKQLEAKSINRRATFLVAVHLLNPLVFTISTRGSSEAVLSLFVLSTLYSALRGRWNSAAILLGLSTHWKVYPFIYGVACLGVISSETGMPSDLRRYVRSFLQWRILKFVLVSASTFAALGMMMYLIWGYPFLHESYLYHLHRLDHRHNFSPYFYLIYLSYPSTSSPLDLVNIPAWQRLLRSPLTSFVPQMVLSIGTGLLFGRRKVDLVFAWFIQTAVFVVFNKVCTSQYFLWYTLFLPLLIPKLHTSVARGLLYLLIWAGTQALWLSEAYRLEFLGQNVFYSLWFRSLIYVVGNCCVLACIVNDYYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JGH3</accession>
    <name>A0A2H3JGH3_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glutamine synthetase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WOLCODRAFT_135883</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the glutamine synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH37859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JGH3"/>
    <dbReference type="STRING" id="742152.A0A2H3JGH3"/>
    <dbReference type="OMA" id="NIMTFRL"/>
    <dbReference type="OrthoDB" id="77835at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamine synthetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006576">
        <property type="term" value="P:biogenic amine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.70:FF:000013">
        <property type="entry name" value="Glutamine synthetase bacteria"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.10:FF:000005">
        <property type="entry name" value="Probable glutamine synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="entry name" value="Glutamine synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.10">
        <property type="entry name" value="Glutamine synthetase/guanido kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43785">
        <property type="entry name" value="GAMMA-GLUTAMYLPUTRESCINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43785:SF12">
        <property type="entry name" value="TYPE-1 GLUTAMINE SYNTHETASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="Glutamine synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51987">
        <property type="entry name" value="GS_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GS catalytic" evidence="8">
        <location>
            <begin position="131"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PCH37859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="491" mass="54512" checksum="7846C9E821EA11AC" modified="2018-01-31" version="1">MANRDPNDLSTTHAPRSIDELKELLRDDIKVKVAGIDVDGVLRGKFMSKDKFLSAAASDGFGFCSVIFGWDIHDTVYSRELLISNKANGYRDLLASIDLSTYRRIPWENNVPFFLVSFLDPNTKEPVCADPRGVLRKVLQRAYAKEWRCFAGCEYEYFQFKETPDTLAEKKFTNLQPLTSGMHGYSLLRTQLNSGYFHDLFDQSLAFDVPLEGHHTETGPGVYETALAYTSASRMADNAILFKFLAKSIGMKRGVVPSFMAKPWGNLPGCSGHIHVSVRDLNGKSLFAVSDAELETGRANAAYPDTKFLSQEGEWFLAGVLDGLPDVMPMLVPTINGYKRLVGGEAFWAPNAVTYGYDSRAASVRIISPPSVPPSATRLEIRVPGADMNPYFALSAVFALGLRGIEKKLSLPGPPVSQLTLEDKQNGKVQMLPQSLEAATERMMRPGSIAREEAVFGNDFVEHFGGTRQHEVKLWNEAVTSWEVERYLELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JGX2</accession>
    <name>A0A2H3JGX2_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WOLCODRAFT_131902</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH41416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JGX2"/>
    <dbReference type="STRING" id="742152.A0A2H3JGX2"/>
    <dbReference type="OMA" id="EQTFFCA"/>
    <dbReference type="OrthoDB" id="276151at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008854">
        <property type="entry name" value="TPMT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32183">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32183:SF11">
        <property type="entry name" value="THIOL METHYLTRANSFERASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05724">
        <property type="entry name" value="TPMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51585">
        <property type="entry name" value="SAM_MT_TPMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PCH41416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="202" mass="22418" checksum="93912E2466A529AF" modified="2018-01-31" version="1">MRLRSIIGEHQADGWDKAWQDGVTPWDSGCPQPALQDLITSGKLDLPRSGRALVPGCGRGYDTLVIATALGLDTLGIDISSTALEAAERVSFQLKDFLALSGTGDEHYELIYDYTFFVAIPPTRRPEWGRQMTKIVKSGGYLITLLFPIINQPENVGPPFYAREESYAAVLGADWENVLDEIPENSIESHKGVEQLIVWKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JH11</accession>
    <name>A0A2H3JH11_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Hexose transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WOLCODRAFT_139839</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467843">
        <property type="protein sequence ID" value="PCH35297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JH11"/>
    <dbReference type="STRING" id="742152.A0A2H3JH11"/>
    <dbReference type="OMA" id="VYRKEQT"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000117">
        <property type="entry name" value="MFS hexose transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF64">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="286"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="320"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="352"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="383"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="423"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="452"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="37"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="499"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="499"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="519"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PCH35297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="539" mass="59927" checksum="9DBCD317C50AE172" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JH40</accession>
    <name>A0A2H3JH40_WOLCO</name>
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        <submittedName>
            <fullName evidence="7">GroES-like protein</fullName>
        </submittedName>
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        <name evidence="7" type="ORF">WOLCODRAFT_134440</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD-104</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467909">
        <property type="protein sequence ID" value="PCH37038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JH40"/>
    <dbReference type="STRING" id="742152.A0A2H3JH40"/>
    <dbReference type="OMA" id="TCQHEDI"/>
    <dbReference type="OrthoDB" id="1560166at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF7">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE-LIKE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="6">
        <location>
            <begin position="19"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PCH37038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="350" mass="37401" checksum="F29DF0422E200983" modified="2018-01-31" version="1">MSSAAHPESYKAYAFLEKGGPLQVIQVQWRDPAPGEIVVKVLACGICASDEIAKFQLMPQVEYPRIPGHEIVGDVAATPSTENRWKIGNRVGSGWHGGHCNTCVSCMVGDYMTCENEDINGIARHGGYAEYVTLRTEAVTPVPEDMSPAEVAPLFCAGVTTFNSLRNMPCKPPAYVAVQGIGGLGHLGIQFAKAMGYRTVALSSSGSKKQLALALGADAFLDGSTADQVAELKKIGNVRVIMCTAPNADIMRDMIPALAPRGTLLVLALTGDTSVNLGSLNVKGLSIRGWPNGPVADCLDCINFAKANGIKVMVESFPFVRANEAFERRSSALFRAVLLPQEQDLPRPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JHI5</accession>
    <name>A0A2H3JHI5_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">WOLCODRAFT_19986</name>
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        <name type="common">Brown rot fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467854">
        <property type="protein sequence ID" value="PCH35467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JHI5"/>
    <dbReference type="Proteomes" id="UP000218811">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
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    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013736222" evidence="2">
        <location>
            <begin position="21"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH35467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="148" mass="15808" checksum="7876010DC5E96BFC" modified="2018-01-31" version="1">MVASGIFALTALACTLVANAAVVPLSPAYTTVDGSVFTTVVSSPDLRAVNGEVFTTVVPSPDPSAVSGSVFTTVVPSSYPSAVNDESPWVCLLDSTLVYYLVILSFWSIENIFAPFLIMTAPEIDSMSLTGITERYVAFYLRYCTQEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JHQ0</accession>
    <name>A0A2H3JHQ0_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RTA1-domain-containing protein</fullName>
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    <gene>
        <name evidence="6" type="ORF">WOLCODRAFT_146917</name>
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    <organism evidence="6 7">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
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                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB467987">
        <property type="protein sequence ID" value="PCH39363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="742152.A0A2H3JHQ0"/>
    <dbReference type="OMA" id="NSTAFMI"/>
    <dbReference type="OrthoDB" id="3358017at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF9">
        <property type="entry name" value="SPHINGOID LONG-CHAIN BASE TRANSPORTER RSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="129"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="165"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PCH39363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="315" mass="35292" checksum="8BF2BB80E7034041" modified="2018-01-31" version="1">MQLEANATQKSNEYFTTSPYGYSPDVWIGILFLLFFGASTLCHLIQAIHYRLWWLFPTVLLAGCMEIIGWIGRLWSSYNLLLKTPYMMQISLTILAPTPLVAANFIMLGQCIRRLGQQYSRLSAKRYTAIFLSCDIIALLVQGAGGGIASMSAGNGTNPDLGGNLMLAGIIFQLGAITIYVLLATEFVLRYLHNKPLKDRINTTTSYSLDTRMKQMLMALAFSSLCIYVRTWYRTIELANGWTGYIIHTQRYFVIMDALMITFAMGVMNIFHPGRLLGPAEMWKESIPMADMNGSAKRADPEYLALRGNLSTPTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JI76</accession>
    <name>A0A2H3JI76_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Carnitine acetyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WOLCODRAFT_28522</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the carnitine/choline acetyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467876">
        <property type="protein sequence ID" value="PCH36384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JI76"/>
    <dbReference type="STRING" id="742152.A0A2H3JI76"/>
    <dbReference type="OMA" id="DVWAKDY"/>
    <dbReference type="OrthoDB" id="240216at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004092">
        <property type="term" value="F:carnitine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009437">
        <property type="term" value="P:carnitine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.70">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000542">
        <property type="entry name" value="Carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039551">
        <property type="entry name" value="Cho/carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042231">
        <property type="entry name" value="Cho/carn_acyl_trans_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589:SF103">
        <property type="entry name" value="CARNITINE O-ACETYL-TRANSFERASE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589">
        <property type="entry name" value="CARNITINE O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00755">
        <property type="entry name" value="Carn_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00439">
        <property type="entry name" value="ACYLTRANSF_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00440">
        <property type="entry name" value="ACYLTRANSF_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Choline/carnitine acyltransferase" evidence="6">
        <location>
            <begin position="36"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600542-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PCH36384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="635" mass="71012" checksum="4F5AF3F151E4B092" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JI95</accession>
    <name>A0A2H3JI95_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">FAD binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WOLCODRAFT_140399</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PheA/TfdB FAD monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467876">
        <property type="protein sequence ID" value="PCH36404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JI95"/>
    <dbReference type="STRING" id="742152.A0A2H3JI95"/>
    <dbReference type="OMA" id="NARWPFE"/>
    <dbReference type="OrthoDB" id="1716816at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02979">
        <property type="entry name" value="PHOX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012941">
        <property type="entry name" value="Phe_hydrox_C_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038220">
        <property type="entry name" value="PHOX_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF20">
        <property type="entry name" value="2-MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G13660)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07976">
        <property type="entry name" value="Phe_hydrox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="11"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="Phenol hydroxylase-like C-terminal dimerisation" evidence="6">
        <location>
            <begin position="425"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PCH36404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="605" mass="66023" checksum="C2EB6AACBE073080" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JIW6</accession>
    <name>A0A2H3JIW6_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_17343</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH41801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JIW6"/>
    <dbReference type="STRING" id="742152.A0A2H3JIW6"/>
    <dbReference type="OMA" id="TIAHTTI"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH41801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="332" mass="36577" checksum="E0E306C1AF33EAD2" modified="2018-01-31" version="1">MRAARTYERQLSTLGSYGIPLWSPGELSVGDVGYIAEDGALFPFSNVLRPEHDPMTNDGVPEGFTPFALNDDTERTQKDYITEHTILSRSVEQSSGISLAPGSRIEYTDSPGARLEIGHHADRTYIPASTSLRDFILQNVSNWFRFITDPQRDVGISLSEIVFVRGVIKTAQTEDTYMTPERKNGPFTTAMDSSSPGGDLTQCIFINCYKLKARPGGMFDPEKGEDDDSTTADIGQENSIEIERDSEFIGKPYNPVDLLLDYILAKACYGTFKSDADVAIAHDEEINQLCKLHSCAITDSNIQDFPRKYQPEVTVCGGVGALTLLVPNPIAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JJK2</accession>
    <name>A0A2H3JJK2_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_83227</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467898">
        <property type="protein sequence ID" value="PCH36864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JJK2"/>
    <dbReference type="STRING" id="742152.A0A2H3JJK2"/>
    <dbReference type="OMA" id="LSENETX"/>
    <dbReference type="OrthoDB" id="2802474at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23272">
        <property type="entry name" value="BED FINGER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23272:SF184">
        <property type="entry name" value="OS03G0311250 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="1">
        <location>
            <begin position="244"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH36864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="374" mass="42404" checksum="46F0CE0F88AB7C02" modified="2018-01-31" version="1">MPVRWSSTYLMLLCADKLKEAVDTFVYEIAHLEKGEKHVALDRLQLSNNEWDRVRKLVDLLTHSDNAQHTFSSDSGPTLHLALPAHKALHRSWTIQIEHIKYNEFKHALEVGTSKIAGYYDRTADSEVYIFAMFLDPSQKKSHIQRYWGEELLQQALKHAETIYATRYKKLYPDGSIMTQIKRTTSVTSAAGHVKCLIDRELSDDEDDLSETGISDNIDPMKPWLHDFHGYLDSVDDLGNCSILNAGCYPVWTSLARDYLAVMTSSVLSDRAFSSTGITISKQRNRLKADVVEALQFLKCAICCDLLFRESPSLLTEADVVDETYEPSQSFETPWDDLIEDISDGDDAEILGGGMMTMCMFLQLCSNSMQSQFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JKN9</accession>
    <name>A0A2H3JKN9_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_152461</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468124">
        <property type="protein sequence ID" value="PCH42431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JKN9"/>
    <dbReference type="STRING" id="742152.A0A2H3JKN9"/>
    <dbReference type="OMA" id="PSTFIHT"/>
    <dbReference type="OrthoDB" id="10262413at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051783">
        <property type="entry name" value="NAD(P)-dependent_oxidoreduct"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079:SF6">
        <property type="entry name" value="NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079">
        <property type="entry name" value="PROTEIN YEEZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="1">
        <location>
            <begin position="83"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH42431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="401" mass="43685" checksum="2611A655111119DA" modified="2018-01-31" version="1">MRRISPQRALPHTGSNITYLTWKWDSKLILTTEYARLRSCLLSTDFAIDDFSCGPEDARGSPYSSEKALVEPSHPGMSPPPDLLASAGFSITTLVRSPEKAAKLDKLGVRAVTGSLQDSDKLTQLSQQANIVIACADADDLAATQAVLDGLQKRNQATREVPVLIHTSGTGVFSDTAAGMYPTSTIYYDSNSEQIESLSPQQLHRNVDLAVLNADAKGAITAYFVLPSTIWGMATGPLVDQGIMNRHSQQIPSLIRASLGRGDAGMVGDGKNMWPNVNIDEVADLYILILDSVLSGRKIGHGRDGFYIGENGEHMLYDVSRAIGEAMVALGRARTNRVSTFSRAELDKYFGGSDYLGSNVRCRAERSRAIGWKPAKTTRDMLVSIRPEIERMLEHPEEVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JL90</accession>
    <name>A0A2H3JL90_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome b5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WOLCODRAFT_86100</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome b5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468054">
        <property type="protein sequence ID" value="PCH40623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JL90"/>
    <dbReference type="STRING" id="742152.A0A2H3JL90"/>
    <dbReference type="OMA" id="SFESTYM"/>
    <dbReference type="OrthoDB" id="432299at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004128">
        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051872">
        <property type="entry name" value="Cytochrome_b5/Flavoprotein_Rdt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46237:SF1">
        <property type="entry name" value="CYTOCHROME B5 REDUCTASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46237">
        <property type="entry name" value="CYTOCHROME B5 REDUCTASE 4 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="6">
        <location>
            <begin position="153"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="12"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PCH40623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="220" mass="23885" checksum="3001F015142973B5" modified="2018-01-31" version="1" fragment="single">YLRSWLFSQDVNATNPSPTIIEPAENTDADDTETIHGGNNNDDTPPSFPSLNSAQRLAPSTQQNVAPRILTDSELMPPPPVPSLAARGPGVASSTGSLAVPLMMVKPPAKLSAKRGKVALAPRRGPLDWANLKKSGHDLRGVDTFLRVTLFMLKQHNSREDAWSAFNGKVYNITPYLPYHPGGEKELMRGAGRDGTLTHAWVNLDYMLDACLVGFLVQDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JLS3</accession>
    <name>A0A2H3JLS3_WOLCO</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_140954</name>
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    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467931">
        <property type="protein sequence ID" value="PCH37594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JLS3"/>
    <dbReference type="OMA" id="GSEDLMW"/>
    <dbReference type="OrthoDB" id="5366606at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH37594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="147" mass="15347" checksum="655780F94ADD9E6A" modified="2018-01-31" version="1">MAPPEFSLRLQHGITGGFAPPTPSAIYTITATPTQPALSISSAVRADGTPSLQDGIVTSLAVDEQTRTLLDELHGILTTIPTEYPPGSEDIYGLDTSIAYGSEDLMWMNGGPQGCGGGVSETQATPEDKAKFKRAVEIVTQLVGKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JLZ6</accession>
    <name>A0A2H3JLZ6_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">HTH La-type RNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WOLCODRAFT_138250</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB468135">
        <property type="protein sequence ID" value="PCH43220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JLZ6"/>
    <dbReference type="STRING" id="742152.A0A2H3JLZ6"/>
    <dbReference type="OMA" id="QFERSIY"/>
    <dbReference type="OrthoDB" id="439993at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08029">
        <property type="entry name" value="LA_like_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12291">
        <property type="entry name" value="RRM1_La"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045180">
        <property type="entry name" value="La_dom_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006630">
        <property type="entry name" value="La_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002344">
        <property type="entry name" value="Lupus_La"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792:SF140">
        <property type="entry name" value="ACHILLES, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792">
        <property type="entry name" value="LUPUS LA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05383">
        <property type="entry name" value="La"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00302">
        <property type="entry name" value="LUPUSLA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00715">
        <property type="entry name" value="LA"/>
        <property type="match status" value="1"/>
    </dbReference>
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            <strain evidence="2 3">MD-104</strain>
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    </evidence>
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        </source>
    </evidence>
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                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
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                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
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                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
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                <person name="Lucas S."/>
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                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
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                <person name="Sabat G."/>
                <person name="Salamov A."/>
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                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
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                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1126/science.1221748"/>
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            <strain evidence="4 5">MD-104</strain>
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                <person name="Ferreira P."/>
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                <person name="Kallen N."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="entry name" value="FAD/NAD-bd_sf"/>
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        <property type="entry name" value="Flavin_mOase"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00370">
        <property type="entry name" value="FMOXYGENASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PCH41963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="529" mass="60002" checksum="BEABB073717B06D2" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JPZ8</accession>
    <name>A0A2H3JPZ8_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">3-isopropylmalate dehydrogenase</fullName>
            <ecNumber evidence="4 13">1.1.1.85</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">WOLCODRAFT_24330</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(2R,3S)-3-isopropylmalate + NAD(+) = 4-methyl-2-oxopentanoate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:32271"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.85"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="13">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="13">Binds 1 Mg(2+) or Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="13">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 13">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.85" evidence="4 13"/>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH40879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JPZ8"/>
    <dbReference type="STRING" id="742152.A0A2H3JPZ8"/>
    <dbReference type="OMA" id="EYDLGAR"/>
    <dbReference type="OrthoDB" id="419183at2759"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00072"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003862">
        <property type="term" value="F:3-isopropylmalate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000006">
        <property type="entry name" value="3-isopropylmalate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01033">
        <property type="entry name" value="LeuB_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004429">
        <property type="entry name" value="Isopropylmalate_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00169">
        <property type="entry name" value="leuB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42979">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42979:SF1">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12 13" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="5 13" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="14">
        <location>
            <begin position="7"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PCH40879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="383" mass="40598" checksum="9A21721E3F9A4C3B" modified="2018-01-31" version="1">MAKKSFRIVVLPGDGIGPEVIAEAVRVLEVISATSPDIELKLESHLFGGCAIDETGQPLPDSTLQACKEADAILMGSVGGPKWDVNSKVRPEQGLLGLRKALGLYANIRPANFASDALLAYSPLKTHVAQGVDIIVIRELIGGAYFGERKELGVAPKEDTAYDTMIYSVAEVQRITRVAAQIALSANPPLPVHSIDKANVLASSRLWRKVVIETLQTEYPQLKLDHMLVDSASMVMVASPRKLNGVIVTENLFGDILSDEVSVIPGSLGLLPSASLAGAPSVADALSPNFKPTPGLYEPIHGSAPDIAGQGIANPIGTILSAAMLLRYSLGLDRYAQAIENAVRKVLDDKSQGGFELRTADLGGKVKTTEIGDKIVEVLKGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JQ83</accession>
    <name>A0A2H3JQ83_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Delta(24(24(1)))-sterol reductase</fullName>
            <ecNumber evidence="16">1.3.1.71</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">WOLCODRAFT_138932</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>ergosterol + NADP(+) = ergosta-5,7,22,24(28)-tetraen-3beta-ol + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16933"/>
            <dbReference type="ChEBI" id="CHEBI:18249"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.3.1.71"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="17">
            <dbReference type="Rhea" id="RHEA:18503"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="15">Steroid metabolism; ergosterol biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERG4/ERG24 family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.71" evidence="16"/>
    <dbReference type="EMBL" id="KB468157">
        <property type="protein sequence ID" value="PCH44316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JQ83"/>
    <dbReference type="STRING" id="742152.A0A2H3JQ83"/>
    <dbReference type="OMA" id="QLPYFCN"/>
    <dbReference type="OrthoDB" id="5326588at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000246">
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    </dbReference>
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        <property type="entry name" value="ERG24_DHCR-like"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257:SF31">
        <property type="entry name" value="DELTA(24(24(1)))-STEROL REDUCTASE ERG4"/>
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    </dbReference>
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        <property type="entry name" value="ERG4_ERG24"/>
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    </dbReference>
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        <property type="entry name" value="STEROL_REDUCT_1"/>
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    </dbReference>
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        <property type="entry name" value="STEROL_REDUCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="14" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="10" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="13" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="4 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="298"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="331"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00029435"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00038892"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH44316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="477" mass="54873" checksum="225C21CC85A003F5" modified="2018-01-31" version="1">MSAVASDTRGGLRQRYATNGTNGVTPTDEGKKMDQKLDSHTEYEFGGPWGVVAIMTGFPILMYYFWICLVFYDGNLVTPSSVDDIQPFLIRMWEHICVDASPNAYAWKVYTGLMVFQLFLAWVVPGYMQEGLPVPSLGYKTLMYKCNAIGCICITMATAAVLHTTGIFRMTEIIDNFGHLMTVAMIYGFGVSFFMYIITVATGNQIRMSGNFIYDVFMGACLNPRIGPIDLKMWLEVRIPWVIVFFMSVSGACKQYETYGYVTPNMAFMCLATWLYLNACGKGEECIPQTWDMFHEKWGFLVIFWNFAGVPFSYIYSVVYMASHDPSKYHFSVPTYVLLYSTLLTAYYIWDTSMSQKSRFKMQTQGITSYRKTFPQLPWGTLKNPSYIQTAHGNRLLTDGWWRYSRKPNYVADWIMSLTWGLVQGTCSGIPYFYSVFFIVVLIHRCGRDFERCALKYGKDWERYCSIVKYKFIPGIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JQB8</accession>
    <name>A0A2H3JQB8_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_154391</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468157">
        <property type="protein sequence ID" value="PCH44352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
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        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH44352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="280" mass="31795" checksum="7D20D2CDA3C6C16A" modified="2018-01-31" version="1">MPRTPRTKLAKRSQSPYQQYASRNGKRAVYKQGARDATTGTAGHWWIPVEIPTHIAKAGKPKPRVEPPPKYTPRVCSEEEQIRASIIAMESQLQNKELNKLLAARAKLDKKIAERRSRKAVPLALRITDPVQGPSVPSTLTTLAPSLTFGKTKYIQAAKHVEPILTSTLTRLTPLANLSIEYPGFDVYYDIKFHQLMCDLEDLVDGLLERARSGRIVNRMWRYMERDCRNIGKVNLEGYERRQAEIIKQIVDTKARFDYGVEEPVKDKPSTVEEDLLATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JQJ3</accession>
    <name>A0A2H3JQJ3_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Pyruvate dehydrogenase E1 component subunit beta</fullName>
            <ecNumber evidence="10">1.2.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WOLCODRAFT_71185</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + pyruvate + H(+) = N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:19189"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10478"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="1.2.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="1.2.4.1" evidence="10"/>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH41079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="742152.A0A2H3JQJ3"/>
    <dbReference type="OMA" id="WYANCPG"/>
    <dbReference type="OrthoDB" id="10266385at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004739">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07036">
        <property type="entry name" value="TPP_PYR_E1-PDHc-beta_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000001">
        <property type="entry name" value="Pyruvate dehydrogenase E1 beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Pyruvate dehydrogenase E1 component subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027110">
        <property type="entry name" value="PDHB_mito-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
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        <property type="entry name" value="PRK09212.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008854">
        <property type="entry name" value="PRK11892.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11624">
        <property type="entry name" value="DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11624:SF96">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0630">Potassium</keyword>
    <keyword evidence="9 10" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="11">
        <location>
            <begin position="42"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PCH41079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="370" mass="39568" checksum="1BDE5B8675673728" modified="2018-01-31" version="1">MSTRAAFSRIAPALTSARAAPALAARRAAFARGYASQAEHTVTVRDALNSALEEEMSRDDRVFIIGEEVARYNGAYKVTKGLMDKFGEKRVVDTPITEMGFAGLATGAAFAGLRPVCEFMTFNFAMQAIDQIINSAAKTHYMSGGGVKCPIVFRGPNGAAAGVAAQHSQDYAAWYGSIPGLKVVSPWSAEDCKGLLKAAIRDPNPVVFLENEMMYGVSFPMSSEAMSDNFLLPIGKAKIEREGSDVTIVAHSLMVTRSIDAADALAKEGVKAEVINLRSIRPLDIDTIKKSIKKTNRLVIVEGGFPGFGVGSEICAQVIESEAFDYLDAPVERVTGADVPTPYAINLEALAFPDAGVVTKAAKRALYRTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JR24</accession>
    <name>A0A2H3JR24_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_133315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468168">
        <property type="protein sequence ID" value="PCH44620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JR24"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH44620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="164" mass="17897" checksum="AB56FA2EF2F6C9B5" modified="2018-01-31" version="1">MVRSLSPAAGRSPTGWKVRSRVGLLPSSAATPRGARRQGQLRRATMMCALTGRRRPRAANKGASASANEDRARGGRERRVMTSTPSVTRPAGARVALATARGPSPGPWQAQPRCCLFCAAGHSNLLWLHLRLQRWLHAPDLSPRERCAAQERRYMGPPLSMNEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JR55</accession>
    <name>A0A2H3JR55_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Kinase-like protein</fullName>
        </submittedName>
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    <gene>
        <name evidence="7" type="ORF">WOLCODRAFT_65955</name>
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    <organism evidence="7 8">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH38487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="742152.A0A2H3JR55"/>
    <dbReference type="OMA" id="IDTIREW"/>
    <dbReference type="OrthoDB" id="193860at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PCH38487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="221" mass="25521" checksum="8360BB0E104E1A9D" modified="2018-01-31" version="1">MHRDIKPDNFLIDADGHIVLCDFGFSHTPAQEEDFEESTFYGRFGTAGYLAPEMIAGTNYTYKADVYSLGLLFVEMFAGMEAPFYHVRDVKEQLAVMKERGLDGLEDIIEDPLQLDLVYTMLQTNADERPTVYQAMGHPYFEDIDWDCVRDRMYMHEYIPTPDRRELRREGTSLRFKTFHLGLDSKYASYDRDSTGKLLPNDVVLQQLKAGDAYDFVYPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JS05</accession>
    <name>A0A2H3JS05_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mob1/phocein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_27153</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
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    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PCH44053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="233" mass="27236" checksum="2E811EC7AD320F2C" modified="2018-01-31" version="1">MRADGTNPSAAEWLQTLNERRSRIRGVRKVRVNGETQEQVVGQKVYLPNILFRLVRNHTPPGQAYNPYEATFRIPQSVTKTDVRSYLLAVYGVKTTYIRTDNYVSPVTRDPRTFSWTHTKRHRTYKRAVVGLVDPFYYPLAVEDMNRAERETREEWLEKNFATKKLQEDQKKEFIRVTRSGSKDFKWRSGATANRGNIVKMIAERRLARDRAILEAKARLQESRKSEISVDVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JVQ0</accession>
    <name>A0A2H3JVQ0_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_154105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468157">
        <property type="protein sequence ID" value="PCH44063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JVQ0"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH44063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="137" mass="15261" checksum="F422702A52FAF1E6" modified="2018-01-31" version="1">MREPLESTESIELGRFHESWDRCDDGTYRHAFPEGPGHHSPSPISEARAIGKALRKPHVSAHMYRDSWMCIARMARAGFERPAESVPARRPTPAAFMRRSSRQRRPLDGVENDARSDQLCGTTPGRVQAAACPHSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JX78</accession>
    <name>A0A2H3JX78_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_24673</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH41334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JX78"/>
    <dbReference type="STRING" id="742152.A0A2H3JX78"/>
    <dbReference type="OMA" id="VWLSILW"/>
    <dbReference type="OrthoDB" id="3364107at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH41334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="170" mass="18398" checksum="0BDB6F947E587E13" modified="2018-01-31" version="1">MNGGYFTFAGLGIATSVLTVITVPAMLVVDLLNTGFFSSMILVELIWFFILWVLFLATGGSAADSLSNYNDQCTFIYAVVNNGCYDVQAVQAFAFLTWIFLMAYNVALLVIAIINWQRGNPIWTSSVKESFTGSKFPSLYPMTSKPAADVPTAPASQELKPIAQDGASPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JXF9</accession>
    <name>A0A2H3JXF9_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptidase C14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WOLCODRAFT_120708</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C14B family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468124">
        <property type="protein sequence ID" value="PCH42528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JXF9"/>
    <dbReference type="OMA" id="MHRIMVT"/>
    <dbReference type="OrthoDB" id="3223806at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12660">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050452">
        <property type="entry name" value="Metacaspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104:SF30">
        <property type="entry name" value="METACASPASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104">
        <property type="entry name" value="METACASPASE-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Peptidase C14 caspase" evidence="5">
        <location>
            <begin position="40"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PCH42528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="352" mass="38820" checksum="A4647521C3D0692F" modified="2018-01-31" version="1">MPPGPPPRPPQEAQHYGPVFQGEDDRRQQPYFQYSQCTGRKKALCIGINYIGQENELKGCINDAHNMRNFLVREYGYQYDDIVMLTDDQANPRSTPTRANLIDAVRWLVRDAQPNDSLFLHYSGHGGLTKDLDGDEESGYDEVIYPVDYQINGQIVDDELHNICVKPLPPGCRLTAVFDSCHSGSVLDLPYMYSHEGKIKEPNLAAEAAQGLLGAVSSYARGDLMGAFGSVSGLVREVAGFSNGARERKRQTKTSPADVICWGGCKDQQTSADTFEGGQAVGAMSYAFMHCLSTFGGVIFTDTGLIIAVGQNKQQSYQQLLVNVREVLYGKYSQKPQLSSSHPIDTNLLFIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JY73</accession>
    <name>A0A2H3JY73_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_26237</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468146">
        <property type="protein sequence ID" value="PCH43849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JY73"/>
    <dbReference type="STRING" id="742152.A0A2H3JY73"/>
    <dbReference type="OMA" id="MLQTCTI"/>
    <dbReference type="OrthoDB" id="2596908at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013823579" description="Mid2 domain-containing protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH43849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="274" mass="26642" checksum="4B49486139ACB471" modified="2018-01-31" version="1">MLGSSKLVVCLLSLYFSSLVAGAPVAAPAPLENALNVVAREPQALAAPTTVQTSNIVQTTSGTMIETCDVVLTPDGNGSVQEVKSCTLTPIGSSSPDSTSVATATAAATAAAGTAPAIVVVGESSIASTAVFTSPATASATVSGAAASAATSAAVSAGGAIATGTAADSTPTPVNNDANGGSAANASGAVASSSASAATVSTTAKAAAVVTFTIPGRHILIIPVGLVIYCTLTGIVMIIVALVTIERVMYRRAFRQRRLAEQGAPMGYGGMGKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JYI4</accession>
    <name>A0A2H3JYI4_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphoenolpyruvate carboxykinase (ATP)</fullName>
            <ecNumber evidence="3">4.1.1.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WOLCODRAFT_26355</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>oxaloacetate + ATP = phosphoenolpyruvate + ADP + CO2</text>
            <dbReference type="Rhea" id="RHEA:18617"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.1.1.49"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.49" evidence="3"/>
    <dbReference type="EMBL" id="KB468146">
        <property type="protein sequence ID" value="PCH43969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JYI4"/>
    <dbReference type="STRING" id="742152.A0A2H3JYI4"/>
    <dbReference type="OMA" id="MRYAGEM"/>
    <dbReference type="OrthoDB" id="184182at2759"/>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004612">
        <property type="term" value="F:phosphoenolpyruvate carboxykinase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00484">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.8.10:FF:000001">
        <property type="entry name" value="Phosphoenolpyruvate carboxykinase (ATP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.449.10:FF:000002">
        <property type="entry name" value="Phosphoenolpyruvate carboxykinase [ATP]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.449.10">
        <property type="entry name" value="Phosphoenolpyruvate Carboxykinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.8.10">
        <property type="entry name" value="Phosphoenolpyruvate Carboxykinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00453">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001272">
        <property type="entry name" value="PEP_carboxykinase_ATP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013035">
        <property type="entry name" value="PEP_carboxykinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008210">
        <property type="entry name" value="PEP_carboxykinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015994">
        <property type="entry name" value="PEPCK_ATP_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00224">
        <property type="entry name" value="pckA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006820">
        <property type="entry name" value="PRK09344.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006821">
        <property type="entry name" value="PRK09344.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30031:SF0">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYKINASE (ATP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30031">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYKINASE ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01293">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006294">
        <property type="entry name" value="PEP_crbxkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68923">
        <property type="entry name" value="PEP carboxykinase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53795">
        <property type="entry name" value="PEP carboxykinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00532">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PCH43969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="562" mass="63063" checksum="FCDA7FB4A855897A" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JZJ6</accession>
    <name>A0A2H3JZJ6_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WOLCODRAFT_138290</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468135">
        <property type="protein sequence ID" value="PCH43308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JZJ6"/>
    <dbReference type="STRING" id="742152.A0A2H3JZJ6"/>
    <dbReference type="OMA" id="CIARIWS"/>
    <dbReference type="OrthoDB" id="538223at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF637">
        <property type="entry name" value="WD REPEAT DOMAIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="457"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="499"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="541"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="583"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="625"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="667"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="709"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="751"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="227"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="412"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="238"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="427"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PCH43308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="798" mass="86886" checksum="48177240320D20D7" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K0E9</accession>
    <name>A0A2H3K0E9_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Isoleucine--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="2">6.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Isoleucyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">WOLCODRAFT_26031</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Ile) + L-isoleucine + ATP = L-isoleucyl-tRNA(Ile) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:9666"/>
            <dbReference type="Rhea" id="RHEA-COMP:9695"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78528"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.5"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.5" evidence="2"/>
    <dbReference type="EMBL" id="KB468146">
        <property type="protein sequence ID" value="PCH43578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K0E9"/>
    <dbReference type="STRING" id="742152.A0A2H3K0E9"/>
    <dbReference type="OMA" id="EIIVIHK"/>
    <dbReference type="OrthoDB" id="1706657at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004822">
        <property type="term" value="F:isoleucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006428">
        <property type="term" value="P:isoleucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07961">
        <property type="entry name" value="Anticodon_Ia_Ile_ABEc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00818">
        <property type="entry name" value="IleRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.740.10:FF:000044">
        <property type="entry name" value="Isoleucine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000176">
        <property type="entry name" value="Isoleucine-tRNA ligase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000004">
        <property type="entry name" value="Isoleucyl-tRNA synthetase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000023">
        <property type="entry name" value="Isoleucyl-tRNA synthetase,cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02003">
        <property type="entry name" value="Ile_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033709">
        <property type="entry name" value="Anticodon_Ile_ABEc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002301">
        <property type="entry name" value="Ile-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023586">
        <property type="entry name" value="Ile-tRNA-ligase_type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00392">
        <property type="entry name" value="ileS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42780:SF1">
        <property type="entry name" value="ISOLEUCINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42780">
        <property type="entry name" value="SOLEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19302">
        <property type="entry name" value="DUF5915"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00984">
        <property type="entry name" value="TRNASYNTHILE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="12">
        <location>
            <begin position="21"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="13">
        <location>
            <begin position="698"/>
            <end position="853"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
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<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K1R8</accession>
    <name>A0A2H3K1R8_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Metallo-dependent phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WOLCODRAFT_138766</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468157">
        <property type="protein sequence ID" value="PCH44068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K1R8"/>
    <dbReference type="STRING" id="742152.A0A2H3K1R8"/>
    <dbReference type="OMA" id="AKPNALM"/>
    <dbReference type="OrthoDB" id="783096at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07383">
        <property type="entry name" value="MPP_Dcr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.100.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32440:SF0">
        <property type="entry name" value="PHOSPHATASE DCR2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32440">
        <property type="entry name" value="PHOSPHATASE DCR2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="3">
        <location>
            <begin position="307"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PCH44068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="680" mass="76549" checksum="10C856B12FBD9022" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K2S9</accession>
    <name>A0A2H3K2S9_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10">Uricase</fullName>
            <ecNumber evidence="7 10">1.7.3.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Urate oxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WOLCODRAFT_25524</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 10">Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 10">
            <text>urate + O2 + H2O = 5-hydroxyisourate + H2O2</text>
            <dbReference type="Rhea" id="RHEA:21368"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
            <dbReference type="EC" id="1.7.3.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Purine metabolism; urate degradation; (S)-allantoin from urate: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7 10">Belongs to the uricase family.</text>
    </comment>
    <dbReference type="EC" id="1.7.3.3" evidence="7 10"/>
    <dbReference type="EMBL" id="KB468124">
        <property type="protein sequence ID" value="PCH42707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K2S9"/>
    <dbReference type="STRING" id="742152.A0A2H3K2S9"/>
    <dbReference type="OMA" id="ATMYKMS"/>
    <dbReference type="OrthoDB" id="9992118at2759"/>
    <dbReference type="UniPathway" id="UPA00394">
        <property type="reaction ID" value="UER00650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004846">
        <property type="term" value="F:urate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006145">
        <property type="term" value="P:purine nucleobase catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019628">
        <property type="term" value="P:urate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.270.10:FF:000001">
        <property type="entry name" value="Uricase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.270.10">
        <property type="entry name" value="Urate Oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002042">
        <property type="entry name" value="Uricase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019842">
        <property type="entry name" value="Uricase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03383">
        <property type="entry name" value="urate_oxi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42874">
        <property type="entry name" value="URICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42874:SF1">
        <property type="entry name" value="URICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01014">
        <property type="entry name" value="Uricase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000241">
        <property type="entry name" value="Urate_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00093">
        <property type="entry name" value="URICASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55620">
        <property type="entry name" value="Tetrahydrobiopterin biosynthesis enzymes-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00366">
        <property type="entry name" value="URICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 7" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="4 7 10" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="16"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="284"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>5-hydroxyisourate</name>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>O2</name>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>5-hydroxyisourate</name>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>5-hydroxyisourate</name>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>5-hydroxyisourate</name>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>5-hydroxyisourate</name>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>5-hydroxyisourate</name>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>O2</name>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000241"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PCH42707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="325" mass="35632" checksum="85CE4135D8EB228B" modified="2018-01-31" version="1">MSASTESYLSHARYGKDKVRVFRVVREGKWHHVVEYNVTALLEGEIDVSYTKADNSVVVATDSIKNITYYLAKISPHILHPERFAIHLGTHLVSKYAHIHKAFVTIEKLRWARIPVAEGVEAAKPHPHAFYRDGDDKRIAKVEIDGTGGKDKLVAKVTSGITDLLVLKSTGSAFENFVRDEYTTLVEVNDRIFSTSIDLSYVFAPFAVPAPQDEKKLGLGLGDAAQGTGWDGEAVAEAARKITLETFATDESASVQATLYKMAQLIIAENASVQSVTYALPNKHYVPVDMKYIGVDNMTPAAAEVFVPIAAPSGLISATISRKQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K3T7</accession>
    <name>A0A2H3K3T7_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6535 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_59025</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DUF6535"/>
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    </dbReference>
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    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
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        <location>
            <begin position="5"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20153"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH43087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="391" mass="44478" checksum="558E18D40790478C" modified="2018-01-31" version="1" fragment="single">AAETWRQCTEKVWEHQSWIVEKWNQEIDTVRSPCASLFSAVVATFVVQYYMQMQPQTPNQSIMALKQIVMQLSKVVKRIDNLPASAASASLTPTEDTDVFTITPYAAIVAVNALWFSALVLSLAAASIAIHVRQWLDYHLIPIPGVPRQSAHLWHLQRASLKTWHVEDILSLMSILLQIALSLFLIGLVVLLWFINRAPAYAVIIQVMTLFAFSTATSIIPAFQASCPYRGPVAWGVIRLMQHVKAGYSDALQWLQDASRTWGRTKTYPPRFKHWLMNMQSRPRPWHQQPANWTEYVTDVLRQQPQDDLMVLASADESINDASFLEKVVRASFATANLGSILPAFTMILQRRAHEVHFEGDHHRMIWHHNTHDVGSIITMGHMSVDIIQRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K3W1</accession>
    <name>A0A2H3K3W1_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GMC oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WOLCODRAFT_121505</name>
    </gene>
    <organism evidence="5 6">
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        <name type="common">Brown rot fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD-104</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468135">
        <property type="protein sequence ID" value="PCH43107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K3W1"/>
    <dbReference type="STRING" id="742152.A0A2H3K3W1"/>
    <dbReference type="OMA" id="ENHIQPA"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF78">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="4">
        <location>
            <begin position="278"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="538"/>
            <end position="539"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PCH43107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="607" mass="66721" checksum="F969EBB954A82614" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K454</accession>
    <name>A0A2H3K454_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WOLCODRAFT_90531</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468146">
        <property type="protein sequence ID" value="PCH43824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A2H3K454"/>
    <dbReference type="STRING" id="742152.A0A2H3K454"/>
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    <dbReference type="OrthoDB" id="1274115at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05374">
        <property type="entry name" value="17beta-HSD-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051911">
        <property type="entry name" value="SDR_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="adh_short"/>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PCH43824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="279" mass="30186" checksum="E552329F81DFDB25" modified="2018-01-31" version="1">MVSSKVWFITGSSSGFGRAMTETALRKGDIVVATLRNPAALSDLAAKYPSDRLLLVHLDVTKADLVTAAFAQAKHAFGRVDVVFNNAGAVVFGEMEGTPEEAARGLFEVNFWGAANVSREAIRFFREENNPSGGLLLQNTSMVCTSSFPLLGYYAATKHALEGLSTSIAAEIEPEWNIKITLIEPGAFQSNIADVAIRPEPHLAYASPTSRVSLFRSNITARELLGNTAKATEVIYKLAGLSKPPLRFPLGKDSVSQAKQLLAEFQTEVDQYGSWSDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K4J4</accession>
    <name>A0A2H3K4J4_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Nucleoside triphosphate hydrolase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">WOLCODRAFT_26357</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB468146">
        <property type="protein sequence ID" value="PCH43974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K4J4"/>
    <dbReference type="STRING" id="742152.A0A2H3K4J4"/>
    <dbReference type="OMA" id="YYGAEHY"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000041">
        <property type="term" value="P:transition metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18583">
        <property type="entry name" value="ABC_6TM_HMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000186">
        <property type="entry name" value="ATP-binding cassette sub-family B member 7, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221:SF654">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B MEMBER 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="109"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="301"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="77"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="395"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="638"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="743"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="7"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="668"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="680"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="866"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="895"/>
            <end position="910"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PCH43974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="910" mass="99724" checksum="0C3B215A0641A59A" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K5B5</accession>
    <name>A0A2H3K5B5_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WOLCODRAFT_138851</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
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                <person name="Kallen N."/>
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    </evidence>
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        <source>
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    </evidence>
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            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">MD-104</strain>
        </source>
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        <property type="match status" value="1"/>
    </dbReference>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="460" mass="50987" checksum="9237652951AF3194" modified="2018-01-31" version="1">MKLDSLLEKIDQLANVPTANTIIIAFDEAHNLATFRRDAKTGEMWSIFGELRRALRSLTQHGLYSVFISTTKSADQLAPPPLDDDPSSSGEEIVNDTFVDVGFDHLVTPYDQYTDPQISDVKLACLSARLALEYERNIRALQEERNQVARHMRAVLFPAGYRPDMVTISLSEPVLAEAARLVFTVFDSPGALLELVRDSYVRVGDRGGAMIRLLLLLACDRKSYPTSYTALENLSYVMVPDFLEELWPGCNVSQAQPTFVSFAEGAEEPLAWPCRRQEPAPTLGEAFKDAKIFFNHFIQLREGMINRVCLRALMMRGAAGVCCPRQSDIKIIIPVLFDGQTLQHEKITAIVVQVTLERRSSNRASLDIFGPMQYKPPIIRVVLAPRAEGESFSTGPFDPDDASSEAFTAYDVWSAGIDKLGPVARGDRSVWDGLLDAALGRTTMFGATQGATLWTMMSVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
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                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
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                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
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                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
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                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH33096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="185" mass="21135" checksum="9FC065C5887A0B9A" modified="2018-01-31" version="1">MQSNSTATSDQVQGQTAIQRTCVYLPLTNAQQKLFAEVLDKCDAFTIRTVDDRCKPVRVEWVVLPSSDATSDDDDMTEDDSSTLEGDLRFEVPEDLDMRWEYTLEAGERVWVKTVEGAWAEGRVADLTPRVGFSSVYVDVHVVYYPVHFRMRDKPMTRRYFAPLNGDIKPDTPAIRRLLHEGGWL</sequence>
</entry>
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    <accession>A0A2H3IT42</accession>
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        <name evidence="11" type="ORF">WOLCODRAFT_159864</name>
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            <taxon>Agaricomycetes</taxon>
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            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the NDC80 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Chromosome</location>
            <location evidence="9">Centromere</location>
            <location evidence="9">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the SPC25 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH33150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0031262">
        <property type="term" value="C:Ndc80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23784">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.457.50">
        <property type="entry name" value="Chromosome segregation protein Spc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045143">
        <property type="entry name" value="Spc25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013255">
        <property type="entry name" value="Spc25_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14281:SF0">
        <property type="entry name" value="KINETOCHORE PROTEIN SPC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14281">
        <property type="entry name" value="KINETOCHORE PROTEIN SPC25-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08234">
        <property type="entry name" value="Spindle_Spc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 9" id="KW-0132">Cell division</keyword>
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    <keyword evidence="2 9" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 9" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="4 9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromosome segregation protein Spc25 C-terminal" evidence="10">
        <location>
            <begin position="174"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PCH33150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="248" mass="28315" checksum="905C25A8AAE501D9" modified="2018-01-31" version="1">MAKNKTPRAPRFDLAAALSSPNPHIDLKLEAFEASTRNFLDAVSRYTHRGIAEITSRKSSHSSDRKQYAERMQQVEIETNICKLKEIELIEVLNREQTEKREAESSVATFRRQLNAVKEICASLDGETEQYRMVTANLRREREGESALLNAHGTNVIPEAVDCQARLQFLIEGISKDNILLRFTSIDSRDHTRDFNLVLDVSSRSYRVPTTTPFVPTLPIMIDELNVTRDIYTFIKAVRQVFKELCVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IUS5</accession>
    <name>A0A2H3IUS5_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_112414</name>
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    <organism evidence="2 3">
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
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                <person name="Riley R."/>
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                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">MD-104</strain>
        </source>
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    </feature>
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        </location>
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    </evidence>
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    <sequence length="449" mass="51254" checksum="2CE97C0902DA3C30" modified="2018-01-31" version="1">MPRRNSNGSNYETKGKSHKAKSASEIARNVEHFHTWSERQRCEQVSISDIPAELQADIQAVFDFKAQLPAEWCKKTSKASRSISFVLPDEFLKFLREIPSGSKLFSKDVLGKDCKQMLSDLQLVFAAWTRLKKMRESSRKWSEADYVANVYNVFRSSAIHESDYQVERTICLPQPLCTTHLKAKELLVLNVQIATPDSSIYIPARYIKDLSHGASSPYMKLKERLQTRARGHGGAESLRYQSTPSQKISTEPGFEFVSAFWEDKKPLQSLLDSAYRQNRMATTSAVRQLHALHINAPIFGLVWSQGKVRAHVDWWIVKPNSDDPTIQSAFYIEPTAGGRRDSTVYHEWDLEDPEDILQVYLLIRNLDRWTTGRFCELVYDGINQLVVDVSEHGQKIVPWRRTGDLRSALHTVPENSPPPNSAATPPASPQRPRTRQATRRPLRRPSDTH</sequence>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
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                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
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                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
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                <person name="Sabat G."/>
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            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5 6">MD-104</strain>
        </source>
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</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IXF5</accession>
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            <fullName evidence="15">Dbl homology domain-containing protein</fullName>
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        <name evidence="13" type="ORF">WOLCODRAFT_95398</name>
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        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
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            <taxon>Agaricomycetes</taxon>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
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                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
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                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
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            <dbReference type="DOI" id="10.1126/science.1221748"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="13 14">MD-104</strain>
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    </evidence>
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        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IZ63</accession>
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            <fullName evidence="11">GOLD domain-containing protein</fullName>
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        <name evidence="12" type="ORF">WOLCODRAFT_139542</name>
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        <name type="common">Brown rot fungus</name>
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            <taxon>Agaricomycetes</taxon>
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            <taxon>Phaeolaceae</taxon>
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        </lineage>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
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                <person name="Sabat G."/>
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                <person name="Sun S."/>
                <person name="Syed K."/>
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                <person name="Wiebenga A."/>
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                <person name="Pisabarro A."/>
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            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="12 13">MD-104</strain>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013964536" description="GOLD domain-containing protein" evidence="10">
        <location>
            <begin position="24"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="11">
        <location>
            <begin position="35"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PCH34725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="214" mass="24178" checksum="30B1B29DC60B8DD2" modified="2018-01-31" version="1">MTLVLLPLISLLVALQLACTVRASALTTAIGANERLCFYADVDKAGEKIGFYFAVQAGGSFDIDFDVKDPSEKVLLDGQRERQGDYVLTANTVGEYAFCFENDMSTLTEKLIDFDIMVESEPRREPPAKPGQISEHTSALEESIFRLNGMLQNVKRTQKYFHTRENRGFDIVKSTQNRLFWYAVLECAGVVGMAVLQVYVLQMFFTKTGRRYRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J0M8</accession>
    <name>A0A2H3J0M8_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">glucan 1,3-beta-glucosidase</fullName>
            <ecNumber evidence="7">3.2.1.58</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WOLCODRAFT_140075</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1-&gt;3)-beta-D-glucans, releasing alpha-glucose.</text>
            <dbReference type="EC" id="3.2.1.58"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.58" evidence="7"/>
    <dbReference type="EMBL" id="KB467854">
        <property type="protein sequence ID" value="PCH35792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J0M8"/>
    <dbReference type="STRING" id="742152.A0A2H3J0M8"/>
    <dbReference type="OMA" id="PLSEPWN"/>
    <dbReference type="OrthoDB" id="62120at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004338">
        <property type="term" value="F:glucan exo-1,3-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF34">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="131"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="160"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="766"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="164"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00036824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PCH35792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="785" mass="84389" checksum="7CEAC8FFC8935B94" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J0N1</accession>
    <name>A0A2H3J0N1_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WOLCODRAFT_126344</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467854">
        <property type="protein sequence ID" value="PCH35810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J0N1"/>
    <dbReference type="STRING" id="742152.A0A2H3J0N1"/>
    <dbReference type="OMA" id="GCTNING"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42986">
        <property type="entry name" value="BENZALDEHYDE DEHYDROGENASE YFMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42986:SF1">
        <property type="entry name" value="BENZALDEHYDE DEHYDROGENASE YFMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="6">
        <location>
            <begin position="20"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="255"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PCH35810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="482" mass="51572" checksum="917B849C2AC87A3B" modified="2018-01-31" version="1" fragment="single">MSIPFVPLYINGQAKPASTDAAFDVHNPYSNEVVTRAASASRQDCQDAVAAAVQAFRSWEHSLLAERRDIFLKAADLLRTERYKTKVLAAMTEEICSVEFLANFNVEIATGMLRYVAGMITELKGETFPSVKRGGHVIAQRRAQGVVLGIAPWNSPLVLSIRAMALPIICGNTVILKTSEVSPRVHYTVAELFEEAGLPHGVLNLVHMSREDAPARTAEIIAHPAVRSINFTGSDRVGRILAAEAAKYLKPCVLELGGKAPAVVLEDADIQTAARAITSSALLHSGQICMSTERVIVSRKVSEALTKAIVAEFSKFKSGGPGERIAAQFTAGSAEGIVSLLREAQAGGAKILLGNVSREGAVVQPHVVAGVKPGMRLWDRESFGPVTIIAEFDSIDEAIDLANATEYSLVGSVWTKDLNNAMDVAMRVRAGCMNVNGPTIHVEDAREHVGLGGASGYGTFSVESFTDVRMIVIHPSSPTSYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J0P7</accession>
    <name>A0A2H3J0P7_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_166318</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467854">
        <property type="protein sequence ID" value="PCH35541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J0P7"/>
    <dbReference type="STRING" id="742152.A0A2H3J0P7"/>
    <dbReference type="OrthoDB" id="2736594at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH35541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="511" mass="57537" checksum="EF4F0577462C6143" modified="2018-01-31" version="1">MKRFWGEVLKKAKSIIVEQRRRFYFDLSQVCPPDVEEQLSEMSPSEGSLSEGSLSETYSPQEHLVPVHLGRNHPPPRYFADNVYCETQSGPRPSPLPIEIWEYILDMFQDRLDLMAVCGRVCRAWRVISKRFTNMNGHRTLTSRVEILRFSQLKRAGLHRDRDVGVAISGLSEVNRMTGSLEHIASLAAMLAGTRPQNTMLSLNDGEWPAWIPQSVFLHLSTFTSITFLTLKDVTFPSIAVFGRLTCALSGLEWLSLLGVSFSDARVPIPLGRRWATPPDLRQVQVDRSRSPSSSDMLRALVATKMVACCRVLISYVDSDILLDYIRDSSLQQALYCAGDSLRALHLGLYHSLPEAKLDCADAEVLVDTGICLSHNTSLSLLEINTSLRRPMNPNHLIWLSRLISHVSTTSIEEIRVVFEEDDSPDDTSFLIIQDIIDDTVGLLDVLRQCASLDDILSASDYTSLETVKFSIRTRFGIWDPTRDELAPWIRSVSRIFPKLHVRGILRAGVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J1S0</accession>
    <name>A0A2H3J1S0_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_134121</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CFA/CMAS family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467865">
        <property type="protein sequence ID" value="PCH36126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J1S0"/>
    <dbReference type="STRING" id="742152.A0A2H3J1S0"/>
    <dbReference type="OMA" id="IAQHFFT"/>
    <dbReference type="OrthoDB" id="506498at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000554">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43832">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43832:SF1">
        <property type="entry name" value="S-ADENOSYL-L-METHIONINE-DEPENDENT METHYLTRANSFERASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02353">
        <property type="entry name" value="CMAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH36126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="358" mass="41209" checksum="EA40DD771C6F7C93" modified="2018-01-31" version="1">MIPEPFLRVGYALLDKGLLPDFILRLAIRALCRQRLHEIDLCSFEANHAAKMEWIEQVRARSVIADFTEKANEQHYEVPTEFMLSCLGPYAKYSCCLYPTGRETLEEAEILMFEMYCEKAKLKNGQNVLDLGCGWGSLTLYLAERYPKSRITGLSNSGTQRAHILSSAAKRGLTNVEVITADINDFDFTDSKSFDRILSIEMFEHMKNYKLLMAKVASWLRPDADSLFFVHIFCHRTTPYHFEEGDGWMARNFFSGGTMPSHDLFLYFQDDLTLLRSDFLSGRHYAQTCEDWLRRQDANAKQGIAELERDAVSKGLGAEEGRKMFYRFRVFYLACAELFAMNGGQEWGVGHYVFKRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J2C9</accession>
    <name>A0A2H3J2C9_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_166519</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467865">
        <property type="protein sequence ID" value="PCH35855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J2C9"/>
    <dbReference type="STRING" id="742152.A0A2H3J2C9"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="364"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH35855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="433" mass="47270" checksum="FAB202BEF8F552C2" modified="2018-01-31" version="1">MTGLGSGNSVQNSLSSIYDTGAHFTADSIQGELFVSRSHRYTHTKDNVGFQDTHWTYDRASEASHSHSHSRQCGKQSSPDTACHYSDSCNPNPSHTGGSVTAIGLPSPLSPDELTMSYLSPSSATQFHGGGYDDHRAIEGPAFSDTVSCSASSSTGSPPLSSPMSAFEHDQYDGSNYVYDPYAHHAYGYANHITNDDPNCTIMHDYATNTHGYPVPECAPHGWFKEEHTDELAPHPCQYTAPQTFYDESRTPRQLSKPNPLLVNTSDLYRRPRSYVYPQFNSDPAFHSAPPSPVEPLLPVIHAPQPQLVSATGVHPVVADYAAGSDAALAHAHRVLTIPTAPLPAEQRPPVIVEDSPKRPLTLACFFCRKRKIACGSPPPGRKDRTCNQCARRNLKCVYPEASRRGMRPKLLYDKDALATVPTRALAREPSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J412</accession>
    <name>A0A2H3J412_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Clavaminate synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_109413</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467898">
        <property type="protein sequence ID" value="PCH36926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J412"/>
    <dbReference type="STRING" id="742152.A0A2H3J412"/>
    <dbReference type="OMA" id="MPAHADW"/>
    <dbReference type="OrthoDB" id="406156at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00682">
        <property type="entry name" value="IPNSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="2">
        <location>
            <begin position="186"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH36926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="363" mass="41195" checksum="E4EC4D457F1FA138" modified="2018-01-31" version="1">MPSTTVPAIPHYVPAAPTSEPLEYADLTVIDLSKATTPEGRAELALQARNAMTEQGFFYAINHGYTQAQRDRIFDIADIPFSAVGDEEKKWYAGNIKATGSYQGYKLRQYWHIDAGVHDQNEAYNINRDVTKKAHPAALRPLLPEIEAFAKFNHHNVLHTILRLLALGMELPEDTFASQHNYAGVGETYVRFMKYYPRTDDDEAKTKNVWLKGHTDFGSVTILWSQPVAALQILSPDGKWRWIKHIDNALVVNAGDAMEFLSGGFYKATIHRVVQPPEDQRGHTRLGVFYFCMPDDNVKLVPHAESSVFRDRQVYRRCDDADAPTMEAWRRGRTSAYGQTELQKKDNVVEEEVINGIVVKHYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-05-03" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J417</accession>
    <name>A0A2H3J417_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_20864</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467898">
        <property type="protein sequence ID" value="PCH36980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J417"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013884197" evidence="1">
        <location>
            <begin position="23"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH36980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="193" mass="21872" checksum="E0E8AB8E1EA5D2F0" modified="2018-01-31" version="1">MTLSAKYSLACFFLHCESCVLAYLLDSSNMRTILDVDNLYWYLVEGHRRPRNISRLKGDAALLQTAQNIPEHAVAMVVVFVVHWYDAPFIFNQNANQWFVRPLSYFIINIWKLLRHKRSKILLTTIAVVVSWLFTDIEQPAVIIEARNTQEGVQTVLSNVIVRGAVACALVVDIYVTSSLCVILRGAKTQSQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J4A3</accession>
    <name>A0A2H3J4A3_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WOLCODRAFT_167294</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD-104</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467909">
        <property type="protein sequence ID" value="PCH37082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J4A3"/>
    <dbReference type="STRING" id="742152.A0A2H3J4A3"/>
    <dbReference type="OMA" id="HEPNWQL"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11069">
        <property type="entry name" value="CYP_FUM15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
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        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EP450IV"/>
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    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
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        <property type="entry name" value="Cytochrome P450"/>
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    </dbReference>
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            <begin position="6"/>
            <end position="26"/>
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        <location>
            <position position="477"/>
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        <ligandPart>
            <name>Fe</name>
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        </ligandPart>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PCH37082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="541" mass="60694" checksum="4C334C8A624C1071" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J4M0</accession>
    <name>A0A2H3J4M0_WOLCO</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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        <name evidence="2" type="ORF">WOLCODRAFT_20639</name>
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    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467887">
        <property type="protein sequence ID" value="PCH36615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <location>
            <begin position="71"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH36615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="373" mass="40926" checksum="E77F19B4FFD302BC" modified="2018-01-31" version="1">MVLTEKAFKAGFLILPLVSSILIQATVDLHKNFHMKQFDPSNVSPNDPHIHEYEKVLEVTDMERALPTIEDLGQTSGGSKHKNLPSSTATGTKWKARMPPPHLPPKTVRHVGAADVTSAAHTMVEDGSAHKLTPTSACPATHASTASKAHDQTSVTTPLTLSMWHPELGMDEATRRKLSYGRMVPSSEGEDGDEESKHEVTSDEEEAQSLAASCTMKGGEKNMAPKAQVKNTKTTKSIPLPKKTKNADASCSLVPYELDGHRFRPIKDTQHALEIAVKAQHDSMEDDKSNVSDIDVDDYMGCTWAENQATYWEDTREDGYLPKAHARAVTIMKGKKPERVPHCSNDQDRQVDPDGLEASFHDDLFNENGGVSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J4M9</accession>
    <name>A0A2H3J4M9_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Proline-specific peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WOLCODRAFT_140756</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
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        <property type="protein sequence ID" value="PCH37190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002410">
        <property type="entry name" value="Peptidase_S33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005945">
        <property type="entry name" value="Pro_imino_pep"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01250">
        <property type="entry name" value="pro_imino_pep_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF33">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G14860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005539">
        <property type="entry name" value="Pept_S33_TRI_F1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00793">
        <property type="entry name" value="PROAMNOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="41"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PCH37190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="302" mass="34097" checksum="92D5C66EEE50AE92" modified="2018-01-31" version="1">MANPSAPAKEGLAPFVHQGETYQTWYKVFGDLTDRTRTPLVGLHGGPGLAHNYLLPLSDLTATASIPVVLYDQIGGVGQRSSYFTDKPHSFWNIDLFIDELESLLAYLSIQDNFILLGHSWGGQLAAEFELRRQPAGLKKIILSNTYSAAAMWGKSTGQLLSAMPKEVQEGMAAGWKNRKLLGPAMKQFQAKHGCTVQPPPEEFWGPINRVFEEDYTPVVEQEMYSSDSELIHWDITDKLHLIRQPVLLINGEADVAQDFVCRSIFERVRKIKWRTFARSSHTPMLEEREEYVKEVLAFLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J5A2</accession>
    <name>A0A2H3J5A2_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_140602</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467898">
        <property type="protein sequence ID" value="PCH36845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J5A2"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH36845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="70" mass="7401" checksum="0281793D766FB31E" modified="2018-01-31" version="1">MCAAPAAMEVAHPAIGVERARNVGPGRPSPTNASVGRRKMMAQRWMGDCRAGAGAASRERRQVRLGIRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J5S6</accession>
    <name>A0A2H3J5S6_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PLP-dependent transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WOLCODRAFT_167615</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD-104</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB467931">
        <property type="protein sequence ID" value="PCH37590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J5S6"/>
    <dbReference type="STRING" id="742152.A0A2H3J5S6"/>
    <dbReference type="OMA" id="FGFECPP"/>
    <dbReference type="OrthoDB" id="1732682at2759"/>
    <dbReference type="UniPathway" id="UPA00528">
        <property type="reaction ID" value="UER00586"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042853">
        <property type="term" value="P:L-alanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000012">
        <property type="entry name" value="alanine aminotransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000151">
        <property type="entry name" value="Alanine aminotransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045088">
        <property type="entry name" value="ALAT1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11751">
        <property type="entry name" value="ALANINE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11751:SF29">
        <property type="entry name" value="ALANINE TRANSAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="7">
        <location>
            <begin position="135"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PCH37590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="522" mass="57561" checksum="55034AF4C56A5401" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J693</accession>
    <name>A0A2H3J693_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WOLCODRAFT_140751</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB467909">
        <property type="protein sequence ID" value="PCH37185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J693"/>
    <dbReference type="STRING" id="742152.A0A2H3J693"/>
    <dbReference type="OMA" id="RTWSAYH"/>
    <dbReference type="OrthoDB" id="10027013at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051052">
        <property type="entry name" value="Diverse_substrate_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44942">
        <property type="entry name" value="METHYLTRANSF_11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44942:SF4">
        <property type="entry name" value="METHYLTRANSFERASE TYPE 11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="4">
        <location>
            <begin position="45"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PCH37185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="318" mass="35902" checksum="2D7C2EEBDFD95480" modified="2018-01-31" version="1">MATFAKTTFNAAKYAAARPTYPKQFYDSIFRFHERATGARWDTAVDLGCGTGQATLELTPFRSVIGIDPSAKMIEQAQRLLEEQTDGESWKLELRERVKYVQGSAEDLSRLVNSSIDMIVSAQAAHWFDWAKLWPEAARVLRKNGTLAVWGYSQFRVAGYPTCTPLINAYSGADSTSTLGPHWEQPGRTILDEHLQAIPDPRTVDYDRQPGTSMWGEFQRVYYVGAHHPALPHALPVLLRKRTTWAGVLGYLRTFSALHSFHEAHPDDLRDPAGDVAVRFWRALRAEVAEQKGRTGEEDDEEEIEIEWPMAVLLARRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J718</accession>
    <name>A0A2H3J718_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Copper transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WOLCODRAFT_64030</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Membrane</location>
            <topology evidence="1 5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH33438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J718"/>
    <dbReference type="STRING" id="742152.A0A2H3J718"/>
    <dbReference type="OMA" id="EAYFIAW"/>
    <dbReference type="OrthoDB" id="73901at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005375">
        <property type="term" value="F:copper ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007274">
        <property type="entry name" value="Cop_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483:SF27">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN CTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 31 COPPER TRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04145">
        <property type="entry name" value="Ctr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0186">Copper</keyword>
    <keyword evidence="5" id="KW-0187">Copper transport</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="131"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PCH33438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="174" mass="18810" checksum="0B04FF0DC84D2687" modified="2018-01-31" version="1">MVPYLHFTSGDNLLFKTWAPSSHGAIAGACIGLAFLAIFERWISAMRAVLTAHWRERTLIIMRGGCHEADSSPSIPSQEKASPDVEEVNVNSLSSKYAGPAVSFRRSPRTVAPFIVAHDLPRGILYAFQALLAYALMLSVMTFQAAFVISIILGLGIGEVLFGRLGGGDSHLLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J7E8</accession>
    <name>A0A2H3J7E8_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_95998</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH37861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J7E8"/>
    <dbReference type="STRING" id="742152.A0A2H3J7E8"/>
    <dbReference type="OMA" id="CMFLQLA"/>
    <dbReference type="OrthoDB" id="3366659at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41390">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41390:SF1">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 213 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH37861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="209" mass="23389" checksum="5FAABB046A418ECA" modified="2018-01-31" version="1">MSSAINGGVVGAVFFSFREYIASPALLSALSDTSYPRRIRELKASREMARRSGDKLTYWDMRLFKIPDTLVSGAFTGGVLNVYKRGPAGLVPGATTAGLVCTFLQLAFNEFDIARVKYVSRRLQEPRESGFTPAISENTAQVQDPEERPKSFLERMLIKLGGQQVSDEEYLDRLKYKRDHLLQRIAELEKERETEESSSKPDSSKPGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J8D5</accession>
    <name>A0A2H3J8D5_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptide hydrolase</fullName>
            <ecNumber evidence="3">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WOLCODRAFT_135903</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M28 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="3"/>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH37885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J8D5"/>
    <dbReference type="STRING" id="742152.A0A2H3J8D5"/>
    <dbReference type="OMA" id="THWAYQK"/>
    <dbReference type="OrthoDB" id="3907302at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016603">
        <property type="term" value="F:glutaminyl-peptide cyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03880">
        <property type="entry name" value="M28_QC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000081">
        <property type="entry name" value="Peptide hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037457">
        <property type="entry name" value="M28_QC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040234">
        <property type="entry name" value="QC/QCL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12283">
        <property type="entry name" value="GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12283:SF6">
        <property type="entry name" value="GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013424462" description="Peptide hydrolase" evidence="3">
        <location>
            <begin position="22"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="4">
        <location>
            <begin position="109"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PCH37885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="401" mass="45013" checksum="E4B4D5414BA36210" modified="2018-01-31" version="1">MLVNFLILLSLSLCLLLECQASKLGKRDFTQLSPSAITSLVSSPDPVINIDPSDPSSHLSHILIPRPPDTDNNTLVKNYIVTMMKNLNWHVEEDTFTDTTPYGSKRFTNVIATKDTSAPRRVILAAHFDSKFFPQYPQSQFVGATDSAAPCAFLLDLAETLDPLLDARQRRLADGEEDDEDVAETTLQLVFFDGEEAFRDWTATDSIYGARHLAHKWATTYIAPHAKRRLLPASTTELSTIEHLILLDLLGAPQPRIHSSFLDTAWLFDAMVSAERRLGNSGAFAYGEQVADAWTSFFVPRGNQFNLGGIEDDHIPFLRLGVSVLHVIASPFPRVWHTLKDDATALDVPTMRRWNLILRVFMCEYLGLRPEATASRDTVQRSFDELDTDTLWDATNATYWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J8D7</accession>
    <name>A0A2H3J8D7_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">L-dopachrome isomerase</fullName>
            <ecNumber evidence="9">5.3.2.1</ecNumber>
            <ecNumber evidence="8">5.3.3.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">L-dopachrome tautomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Phenylpyruvate tautomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WOLCODRAFT_64368</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>3-phenylpyruvate = enol-phenylpyruvate</text>
            <dbReference type="Rhea" id="RHEA:17097"/>
            <dbReference type="ChEBI" id="CHEBI:16815"/>
            <dbReference type="ChEBI" id="CHEBI:18005"/>
            <dbReference type="EC" id="5.3.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-dopachrome = 5,6-dihydroxyindole-2-carboxylate</text>
            <dbReference type="Rhea" id="RHEA:13041"/>
            <dbReference type="ChEBI" id="CHEBI:16875"/>
            <dbReference type="ChEBI" id="CHEBI:57509"/>
            <dbReference type="EC" id="5.3.3.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MIF family.</text>
    </comment>
    <dbReference type="EC" id="5.3.2.1" evidence="9"/>
    <dbReference type="EC" id="5.3.3.12" evidence="8"/>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH38466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J8D7"/>
    <dbReference type="STRING" id="742152.A0A2H3J8D7"/>
    <dbReference type="OMA" id="YINFFDM"/>
    <dbReference type="OrthoDB" id="255819at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004167">
        <property type="term" value="F:dopachrome isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050178">
        <property type="term" value="F:phenylpyruvate tautomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.429.10">
        <property type="entry name" value="Macrophage Migration Inhibitory Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001398">
        <property type="entry name" value="Macrophage_inhib_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014347">
        <property type="entry name" value="Tautomerase/MIF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11954">
        <property type="entry name" value="D-DOPACHROME DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11954:SF6">
        <property type="entry name" value="MACROPHAGE MIGRATION INHIBITORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01187">
        <property type="entry name" value="MIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55331">
        <property type="entry name" value="Tautomerase/MIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0202">Cytokine</keyword>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00036735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00036823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PCH38466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="119" mass="13263" checksum="8DA88EA4A069FE46" modified="2018-01-31" version="1">MPSLELKTNVPLADPKPFLLEFSKFAAATLGKPELYISVSYHYNENLTFHGSFEPAFLMTVTSLDNLTPALNEGYSKAFFDYFESKLGIANDRGYITFLDPGRVNLGYKATTFGTIFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J8M4</accession>
    <name>A0A2H3J8M4_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WOLCODRAFT_133718</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467843">
        <property type="protein sequence ID" value="PCH35089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J8M4"/>
    <dbReference type="STRING" id="742152.A0A2H3J8M4"/>
    <dbReference type="OMA" id="AVNSFWF"/>
    <dbReference type="OrthoDB" id="972532at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051350">
        <property type="entry name" value="WD_repeat-ST_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22838">
        <property type="entry name" value="WD REPEAT PROTEIN 26-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22838:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="299"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="333"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="381"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="412"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="658"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="56"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="506"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="967"/>
            <end position="1021"/>
        </location>
    </feature>
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        <location>
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            <end position="83"/>
        </location>
    </feature>
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        <location>
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    </feature>
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            <end position="1004"/>
        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH35089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="1031" mass="115250" checksum="A3C497DBE4A246AA" modified="2018-01-31" version="1"> </sequence>
</entry>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
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                <person name="Benoit I."/>
                <person name="Boyd A."/>
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                <person name="Copeland A."/>
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                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
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                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
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                <person name="Larrondo L.F."/>
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                <person name="Ling A."/>
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                <person name="McLaughlin D.J."/>
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                <person name="Morin E."/>
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                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
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                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
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                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
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                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
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        <source>
            <dbReference type="EMBL" id="PCH38095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="109" mass="11738" checksum="E867E202B2614E87" modified="2018-01-31" version="1">MTASPRPETPEPDSRQGRRNVAAGVQLLDDDGAISIQLESCLMHIFAKYCVPRPAPGAVGALLVPPPDAYLDEEGLDRWAADTNGAPFDEETKEELLEFLDVTDDGGLT</sequence>
</entry>
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    <accession>A0A2H3J9W9</accession>
    <name>A0A2H3J9W9_WOLCO</name>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
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                <person name="Barry K."/>
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                <person name="Yadav J.S."/>
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                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
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                <person name="Larrondo L.F."/>
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                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
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                <person name="Slot J.C."/>
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                <person name="Stenlid J."/>
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                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
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                <person name="Pisabarro A."/>
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                <person name="Martin F."/>
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            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD-104</strain>
        </source>
    </reference>
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        <text evidence="1 4">Belongs to the peptidase A1 family.</text>
    </comment>
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        <property type="protein sequence ID" value="PCH39030.1"/>
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        <property type="term" value="F:aspartic-type endopeptidase activity"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="417" mass="43708" checksum="7DC872253807D46F" modified="2018-01-31" version="1">MFCKASLLTVALALAASAIPIADDTGIRIPLKKRSSLTRPDGSFDREAALRQQVKVQNKHRLNLMKIDQNIGLKNYNPTAHIPPPATVPSSSANVTRRQSVSLTDQESNAEWTGTISIGTPGQDFVIDFDTGSSDLWVPSSSCSGCEAQHSYNPNSSSTSKEQSGTFQIQYGDGSTASGPIYTDSVSVAGVSVTGQYLSAVTSESGDLVGGPNDGLMGMAFPAISQLGHNPYFWTAIDQKAVSSGVFGFKLSSSGAELYLGGTDSSLYSGDIEYHDLASSAGYWQIGGASALVNGKTVVSNFETIIDSGTSLMYGPPDAVKTFYAAIDGAQEVQSGTYSIPCDSVPTVAFTWGGKTWEISPDDFNLGTLSDGSCQAALGGQDLGFGDNVWLLGDTLMMNVYTAFSVDNNAVGFAALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JA04</accession>
    <name>A0A2H3JA04_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DUF300-domain-containing protein</fullName>
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        <lineage>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="742152.A0A2H3JA04"/>
    <dbReference type="OMA" id="CIKLIVM"/>
    <dbReference type="OrthoDB" id="5348404at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005178">
        <property type="entry name" value="Ostalpha/TMEM184C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23423">
        <property type="entry name" value="ORGANIC SOLUTE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03619">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01417">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="200"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="235"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PCH39036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="384" mass="42969" checksum="228EE5F2FE9A898A" modified="2018-01-31" version="1">MVNSTLCPSGNTAVVDQEGFWSSNGVQWDAHRIGWLIGGVCAAVTVAITMINVLQHARHYNNPAEQRQILRVLYMPAVYAVISFFSYRFFRSYTYYSFIESAYESVTLSAFLLLLIEYVAATAAGHNVDNAIARKDKTKLPLPFCCLRYRPTKAYFMYTLKWSVLQYVIIRPVLSIVGIICQAKGVLCESGPWSFKTANAYIEVIDGISITFALYGLIIFYGLTKDELKGKRPLAKFLSIKLIVMFTFYQGLVFDALEGRVIHATEYWTETNIADGLNALATCIEMVCFSAFMVYSFSVKDYKIPGSPTTRIGQPLLDSINYSDFAIEIAGSLKFFIDYMRGRPYTRRPRVTTVDADGKTRPRMGLGEAFGIAATGVAYPYSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JAI5</accession>
    <name>A0A2H3JAI5_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WOLCODRAFT_168136</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="PCH39216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF153">
        <property type="entry name" value="RECQ-LIKE DNA HELICASE BLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD/DEAH-box helicase" evidence="5">
        <location>
            <begin position="24"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PCH39216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="145" mass="15911" checksum="0500135C29BDF0FB" modified="2018-01-31" version="1">MLTPYYAEIKEKLRTIFNLVDFRSNQLEAITATLAGRDVLVLMPTGGGKSLCYQLPAVCESGTMRGVTIVIGPLLSLMQNQVESLEEKGVDVVQFNGDQDLEESGRVGRRLLAAKKPNILFVTPESGGLIGRFERREDVGTALLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JAL8</accession>
    <name>A0A2H3JAL8_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MarY1-like reverse transcriptase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_60052</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467976">
        <property type="protein sequence ID" value="PCH39246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JAL8"/>
    <dbReference type="STRING" id="742152.A0A2H3JAL8"/>
    <dbReference type="OMA" id="NCITSEP"/>
    <dbReference type="OrthoDB" id="2446696at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.370:FF:000003">
        <property type="entry name" value="Transposon Tf2-6 polyprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000003">
        <property type="entry name" value="Transposon Ty3-G Gag-Pol polyprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH39246.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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            <taxon>Phaeolaceae</taxon>
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        </lineage>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
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                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
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                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
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                <person name="Slot J.C."/>
                <person name="St John F."/>
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                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A2H3JAQ0"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH39310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="131" mass="14097" checksum="1866F64F41E4EB98" modified="2018-01-31" version="1">MLLLTDEDRLSLITYTTTTITVSDGHQQTHTPFKVVAPEHRIATPSTRAGSSHMVVPGQPMSALHSSSSALSLTTNGTPFSMLSPFKKMPSSRLPSIPHIQLAAMNVSLSSPHNTPPLHTRIRIYGTDTGP</sequence>
</entry>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
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                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
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                <person name="Syed K."/>
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                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
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        <property type="match status" value="1"/>
    </dbReference>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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    </feature>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH39041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="189" mass="21579" checksum="BCC76301A6AD740B" modified="2018-01-31" version="1">MALSKNLTAGPILVGVLISTFLYGISTLQTYNYSRIYAKDPLWLRCLIVRRVLETVLTVLTCAYQYSISVTNFGNYGVYNDLPWTIAITFFLSGFIGGIVQSFFAWRIFVISGHWWTSLPPWLGSLARVGVVIAMCTFTLQTHSRSVYEDQYGWTIDLALSLALFTDAWNTICLCYYLHTRRSKHRKCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
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                <person name="Benoit I."/>
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                <person name="Ferreira P."/>
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                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
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                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468053">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JDA6"/>
    <dbReference type="Proteomes" id="UP000218811">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH40232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="137" mass="15349" checksum="8EDACEA3CAED3EE0" modified="2018-01-31" version="1">MRFEGQMPPSILLPSSPVHQPHSSHSVSTVTRVYALLASRLHVRPAAHSSRALVRTIRDATIPLSLPPLLTARRISRRGCHSPRLLGAWRCQGHEGIVKPSVCRAHRWSAGCMHSMGLRSSSATFRHDRHMRRRCQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JDS5</accession>
    <name>A0A2H3JDS5_WOLCO</name>
    <protein>
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            <fullName evidence="2">Uncharacterized protein</fullName>
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    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
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            <taxon>Phaeolaceae</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
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                <person name="Lundell T."/>
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                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD-104</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468053">
        <property type="protein sequence ID" value="PCH40540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JE78"/>
    <dbReference type="STRING" id="742152.A0A2H3JE78"/>
    <dbReference type="OMA" id="ECMDHMA"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11059">
        <property type="entry name" value="CYP_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF164">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="3 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="413"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PCH40540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="470" mass="53751" checksum="84E25C1A9734D03B" modified="2018-01-31" version="1">MLTIYLLGLGILWIVYDHLLLSPLSKIPGPPLACATRLVLMYYEFTRRRRRWIHQLHVKYGPVVRIAPDEVSFANWDAVKEIYVSDGSGYDKTSFYHLFDNYEHECMFSTLDKTPHGERRKRFSDRYSKSFIMQAEVMDGIRERAEGFVARCTEKAGVAADIYILLHCYAIDCITRHLYDPQGMRSLTEAADLMTVKELLFTDNFRESYFQYYFPDLSRLLSRVFSPANRLRLLAARTLNATRRSDISNHTVLSKFKSSSEQLETKSIASELLDHAIAGIDTAGDGLCFLLHHLSLPASASIQEALRAELTEKEGTPIDGLPYLDAVVKEGLRCFSPVPMSLPRRVPKGGRTIAGAYVPEDTIVSCQAYTLHRLNADVFPDPEEFRPERWLKKEYVLERNHLFFAFSTGGRGCIGKHLAMLEMKMLLKEVYSTCRTHISPEMTASMEQLDEFITTRPIDQKCLIVFEKVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JEC0</accession>
    <name>A0A2H3JEC0_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_68658</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468053">
        <property type="protein sequence ID" value="PCH40580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JEC0"/>
    <dbReference type="OMA" id="CIINSAT"/>
    <dbReference type="OrthoDB" id="3251775at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="2">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH40580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="207" mass="23704" checksum="3F73E58BC1E21704" modified="2018-01-31" version="1" fragment="single">IVVAVTVSILDHLVNFRREILFVWKQPWSAAHALVTFNRYAGQASLLFIAILWQYNRNILRFIRSCKAFAILNGVYCIINSATSQFILILQVYGLWDNRKSVKHALIGGFIVCFTCSMIFVLITEMNRITAQLSYSSFLSACIITSKPVYVIGIWGGMTMYDLFVLALLVANTLSRPRRYDSEILTNLFRNGLWSFLVRCSVTVYYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JEN2</accession>
    <name>A0A2H3JEN2_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Mitochondrial import translocase subunit Tom22</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">WOLCODRAFT_131159</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tom22 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468053">
        <property type="protein sequence ID" value="PCH40005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JEN2"/>
    <dbReference type="STRING" id="742152.A0A2H3JEN2"/>
    <dbReference type="OMA" id="LVWIVTT"/>
    <dbReference type="OrthoDB" id="10016939at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22884">
        <property type="entry name" value="TOM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005683">
        <property type="entry name" value="Tom22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12504">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12504:SF0">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM22 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04281">
        <property type="entry name" value="Tom22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
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        </source>
    </evidence>
    <sequence length="265" mass="28912" checksum="6C6B7999894A064C" modified="2018-01-31" version="1">MFDIAPEERNGLLCDITSEGIKRWVTEIGEPCMKVEHMERVADPTVVAALFSLILTIRNKLHALGHYVPKDPFLDPLGFTKALSAYQTSKPHGHAHNLVHSHGPRPSSPGPSSSPPLGTAAPGTNASPNPPTGHLSQQLVESIQNAYEKKARQSESYKVHRVLKSKLDDLASDLRTGGSGDEGPGGTSGAASSVNPTVDLDAFVKVVVGGSKEAPNSLRYLWTGRPDEVQKKRREKRPLHPIRRRFIFSDRKLASEVTMRTPRPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JFR4</accession>
    <name>A0A2H3JFR4_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_137147</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH41042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JFR4"/>
    <dbReference type="STRING" id="742152.A0A2H3JFR4"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013924416" evidence="2">
        <location>
            <begin position="20"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH41042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="130" mass="14230" checksum="5B25424061277FFA" modified="2018-01-31" version="1">MPYNMIYLALHLLLSKLYANSLLATLNYRQVQHARRMSQSEGGAHPLSSTRSMRADATLPYSVKDCFVPTPEVHVETTVVSDASGATAVNKRWSAGESSIDKDPSKQKTSGPGVRVDEVNEPTNESYCSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JG30</accession>
    <name>A0A2H3JG30_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Mov34-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WOLCODRAFT_118324</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M67A family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH41152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JG30"/>
    <dbReference type="STRING" id="742152.A0A2H3JG30"/>
    <dbReference type="OMA" id="KTGRHEM"/>
    <dbReference type="OrthoDB" id="605656at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08069">
        <property type="entry name" value="MPN_RPN11_CSN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000001">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050242">
        <property type="entry name" value="JAMM_MPN+_peptidase_M67A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056263">
        <property type="entry name" value="RPN11_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10410">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23594">
        <property type="entry name" value="RPN11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102712">
        <property type="entry name" value="JAB1/MPN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="8">
        <location>
            <begin position="31"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PCH41152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="308" mass="34350" checksum="B7208E7A3AC83B9B" modified="2018-01-31" version="1" fragment="single">MESDLDRMLQFAGGGRHGGGETTVPDNAETIHISSLALLKMLKHGRAGVPMEVMGLMLGEFIDEYTVQVIDVFAMPQSGTSVSVESVDHVFQTKMVDMLKQTGRSEMVVGWYHSHPGFGCWLSSVDTNTQQSFEQLDPRSVAVVVDPIQSVKGKVVIDAFRLIPHHSVVAGQEPRQTTSNVGHINKPSIQALLHGLNRAYYSINVDYRKSELEQSMLMNLHKRNWTEGLTLRDFKSHKESNEKAIKAMLSLSEAYNKSVQEESTLTAEQLKTRHVGKQDPKRHLEEQVEKAMGNQVVQNLGTMLLAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JGL0</accession>
    <name>A0A2H3JGL0_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA replication licensing factor MCM7</fullName>
            <ecNumber evidence="12">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">MCM7</name>
        <name evidence="15" type="ORF">WOLCODRAFT_96073</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="12"/>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH37899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JGL0"/>
    <dbReference type="STRING" id="742152.A0A2H3JGL0"/>
    <dbReference type="OMA" id="AQHVTYV"/>
    <dbReference type="OrthoDB" id="3207464at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097373">
        <property type="term" value="C:MCM core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17758">
        <property type="entry name" value="MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000004">
        <property type="entry name" value="DNA replication licensing factor MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000288">
        <property type="entry name" value="DNA replication licensing factor MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008050">
        <property type="entry name" value="MCM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF26">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24901">
        <property type="entry name" value="WHD_MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01663">
        <property type="entry name" value="MCMPROTEIN7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="14">
        <location>
            <begin position="354"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="700"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="706"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="725"/>
            <end position="741"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PCH37899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="790" mass="89441" checksum="7E9D5C3DD9847185" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JGQ6</accession>
    <name>A0A2H3JGQ6_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">Complex III subunit 9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WOLCODRAFT_118784</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The complex plays an important role in the uptake of multiple carbon sources present in different host niches.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein, 2 core protein subunits, and additional low-molecular weight protein subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion inner membrane</location>
            <topology evidence="1 12">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the UQCR10/QCR9 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH41362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JGQ6"/>
    <dbReference type="STRING" id="742152.A0A2H3JGQ6"/>
    <dbReference type="OMA" id="IKHKYEV"/>
    <dbReference type="OrthoDB" id="44067at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045275">
        <property type="term" value="C:respiratory chain complex III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.260:FF:000001">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.260">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008027">
        <property type="entry name" value="QCR9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036656">
        <property type="entry name" value="QCR9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12980:SF0">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12980">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX, SUBUNIT X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05365">
        <property type="entry name" value="UCR_UQCRX_QCR9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81514">
        <property type="entry name" value="Subunit X (non-heme 7 kDa protein) of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="15"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU368056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PCH41362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="59" mass="6921" checksum="4CA64D01C344FF93" modified="2018-01-31" version="1" fragment="single">LANTFYNTIVKRNSVFVSTIFAGAFAFGVSFDVGITKFWDNWNKGKQWKDIRHKYVQEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JHM0</accession>
    <name>A0A2H3JHM0_WOLCO</name>
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            <fullName evidence="1">Uncharacterized protein</fullName>
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        <name evidence="1" type="ORF">WOLCODRAFT_24914</name>
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    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH41672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JHM0"/>
    <dbReference type="OrthoDB" id="3243439at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH41672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="69" mass="8390" checksum="C7AB9E75A6DB79CC" modified="2018-01-31" version="1">MTQLHPTLRQAETLLRNFSNRDKREMSRIAKLRTDAEVFTQQRSWTPRYRDMWREWLERKGADIAIVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JI20</accession>
    <name>A0A2H3JI20_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_159079</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Phaeolaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467998">
        <property type="protein sequence ID" value="PCH39493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JI20"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="222"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="72"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="222"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH39493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="502" mass="57324" checksum="8AA2538950A38B8C" modified="2018-01-31" version="1">MPADRYQESVKKVEAQLPPPNKQVVTNVATGKPELWDIPSWSVKKVKDLVPNHKYRGPSWNPAAPWRSIVVKHTEEERKQLLEQRYEEYDRLREAAERHRALRTSERRLESAAEQSYLDKVVTNYPGYHPTPVMPASLLDRVISKETAARIAKEVRIESEWVADHFHLLPNDTEHDLITIMYKKYKWALRLLPILEETKRILGKLYVLILDDPSPFYQEPASQAVMSQNSRSTSPVVTPGMEARNPTTQPNPLGLINTIRISRVAPPIPFVTLQAETNVVDKTFPPVPVGPLPKSVTLPGAYGPYQQLIRDRIMEIEYPALDAAYPRLLRGIPEEEQPRLGNEVSIGYNAIMEAADVAAALAEEAQRKLASRLDSRFSTLFKRRRKGNRPSEEDTAELPEKEIIKVNSIWDTPVDILGEGGPNNPLISWLESLVDEETTMLTQLVAEIFEKDFEEAEDSEEPEPIDIKKWKSLVPEQYHEFIPTVFSQKASERMPERKPLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JID4</accession>
    <name>A0A2H3JID4_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_29663</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
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            <taxon>Phaeolaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468020">
        <property type="protein sequence ID" value="PCH39623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JID4"/>
    <dbReference type="STRING" id="742152.A0A2H3JID4"/>
    <dbReference type="OMA" id="NLWQCAC"/>
    <dbReference type="OrthoDB" id="2785713at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH39623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="448" mass="49410" checksum="A79D18E9C8ECB353" modified="2018-01-31" version="1">MKRLLDLNDDVLATILSFVRPADAIQLALTCHDAYSVAMPRYLSDVALGDTDPAVMSGPDQISLFCKYMLADVARRLRHLKALHIREGAFSRDAEGRDDWVSDYSCAPILAETLRQAFNLRTLAIHDLEPLLAAEPALADAFAPLTRLRDVAFHYIGKCTLQMLKLTTCHPQRLEFGMWKDGARVSGDTAAFYTYAGSLCTLNLWQCACLLESLSEDYVSHGVRTLGLGGRIPFLSMAARQFPNATRITFAEECSIGEEAPVAAWSALDYVEGNMPIPFFACRVRRIDLRFTLGAKLRPFSAETAFARTVEMLRQTSPVVLALKIDPALGPAKLAQLVAVLPRLRFLELALHTEERQDADRWMKEYVPCLAKTPLVGLALRGQGRPDAAPEIARLAAATIPTLAHAGVCPAQRWTWFRAERAARGEPVLEALSGTRGEYVGNELRALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JID9</accession>
    <name>A0A2H3JID9_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycoside hydrolase family 5 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WOLCODRAFT_136320</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
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            <strain evidence="7 8">MD-104</strain>
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        <property type="entry name" value="Golgi alpha-mannosidase II"/>
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        <property type="entry name" value="GH"/>
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        <property type="entry name" value="GH5_C"/>
    </dbReference>
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        <property type="entry name" value="Glyco_hydro_5"/>
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    </dbReference>
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        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
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            <dbReference type="EMBL" id="PCH38519.1"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
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                <person name="Stenlid J."/>
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                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
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                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="456"/>
            <end position="478"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
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        </location>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="488" mass="51949" checksum="8EFCF53FBE21E178" modified="2018-01-31" version="1">MWQLEPRAQRPSARERATSTASSASTPSSYALVSSDLDVSSSFAASLENGLASESDDLPISSPALSSPLSASVDEHAGFTLLTHSQTQNGSQGSSQSAGQGTLRHRSIASPPRHHPRLNLTSSYSSVESLHTASGRLLTLHLEKAESMIWPGLVVGPAPEALAPSMLGAYPWAPADEEAYNMDPTSLMLIALDLYDVRDAREEAFEYFVRAWHQAHVPSATIRLATHYFPAHSDPTSLPPESPAPTVTSPTTPNPTSDAFLPESESPSPVPDTPAYYLARIGGAPGLAQLLLSAGLLHLEGAAAPLLSSAYAGLSSLRAPLTVSGRDGRGYEHTSAGGLTAGGEDAWRRDRACARRYFERVRALAPALDVPLLPPDTSDSEPDVEAESDRVKDRGSGAEPGKRGPPVPAADVPGEKDAQTQTRRRRRKEATDLSSSFVESCRTDPKSDDTYDDRTWYLYIPSLVGAGTALLVVGFLSLSSWRKSQGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
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                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
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                <person name="Benoit I."/>
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                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
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                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH42496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="310" mass="34816" checksum="DE4B20238674A6B9" modified="2018-01-31" version="1">MSGTVSVWYLFHDGQSVPSKVKVDVDADVSDLRDAISDKLHSQRIGVESLSLTLWKPIKELPNGNEAKDVPAGWIREAKGRFDDTVATELKKPQERVNQIIGSGVEQANNSLVRVIVLSKFPELQKRPAEDKDSEGQKRRKLESTGEPLETGNRRKLIIAGHQRVLEELPAPSIAAKKTQLKKYMSEGQPWLNTGQPFGAVGPPVSIYHPVFAEFLKLVVDTDRFPDSDTLDAALELVEESSKFYPNVGKRQKNINKLLARFLEHDIVPTRLSDKSRMICIPCQKVNATVGLVFLEYLEYKSRPIFKCLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
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    <name>A0A2H3JK24_WOLCO</name>
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        <recommendedName>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
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    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH42750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="147" mass="15979" checksum="8CCBE87D61C1D269" modified="2018-01-31" version="1">MSELFGGSCATFPSITTPVRWQHRSADKNAPSPSRGSILGGKRVDAGHFWCIFGIEGPSRTSRSYLSTRISSGGGRTVVDESFIFHARWYRRFASGVLSLSGSADEVARMQRLYGGLRHKLTASPQEGAPASKYDGDQEATRLGPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JKS3</accession>
    <name>A0A2H3JKS3_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_89997</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468135">
        <property type="protein sequence ID" value="PCH42806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JKS3"/>
    <dbReference type="STRING" id="742152.A0A2H3JKS3"/>
    <dbReference type="OMA" id="IHRSYDY"/>
    <dbReference type="OrthoDB" id="2501127at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH42806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="184" mass="20723" checksum="4DF6096F4A757179" modified="2018-01-31" version="1">MAFGIGTINGIRTALYVTLFIFSAVLIGLTAARLHYTTHLKWWDPLDGGVPFYDPIVAELLASACISLLWSLFALHVLFPSSRYEYGVFSSFAAEMVGLFILFLLWLVGAAIASTMWGNLGWCHIYEPCRLLTALVAFAWLGWIMLLFLLFINVLFAVINRALLWQMHGRYNPHASAFSRTVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JKU3</accession>
    <name>A0A2H3JKU3_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_144225</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468135">
        <property type="protein sequence ID" value="PCH42826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JKU3"/>
    <dbReference type="OMA" id="HICIFLA"/>
    <dbReference type="OrthoDB" id="2752889at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="243"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH42826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="388" mass="41817" checksum="3F2F3FE43F4D3C97" modified="2018-01-31" version="1">MSLLSASVPSLPALSRGTTSDGSVTTSSGLSSGLCTPDDVEIAEEFFVRGAAKQGFGANAQVEDELSTPRPGYVLDEAALLEDFTSSSISPSKPRPLSRALERAKKLAERTWTVRKSLRKKNSRHVMGGEKVTSSAFYQSEDDAAGSNNTLAQASPTISCRAIREMSSDAELSRELSNVDFDPDDSREEGLQAYSSDVVAGLRDISLESTLEEHLKALDELPLDSGVAAQRQPLTVRRLSASFLRLLLFLPWCVAVGGTIIVAPRFLEHVAFAPGYIRPDTGTRRFGFWADCGIPHIVIFLATLAALAWWDLRDGVAVAAAVAAGFMYAWRDFRPDFSVPLGSDDRQSIYLVVTKVYLKEGFVMRSSIDRKDTGNAGDVGKGAPSGGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JKU7</accession>
    <name>A0A2H3JKU7_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Thiamine diphosphate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WOLCODRAFT_131429</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468053">
        <property type="protein sequence ID" value="PCH40473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JKU7"/>
    <dbReference type="STRING" id="742152.A0A2H3JKU7"/>
    <dbReference type="OMA" id="DMCFPGD"/>
    <dbReference type="OrthoDB" id="2867507at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005948">
        <property type="term" value="C:acetolactate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07035">
        <property type="entry name" value="TPP_PYR_POX_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
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                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
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                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
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                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
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                <person name="Kumar T.K.A."/>
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                <person name="Martin R."/>
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                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
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            <dbReference type="PubMed" id="22745431"/>
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        </citation>
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        <source>
            <strain evidence="1 2">MD-104</strain>
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            <dbReference type="EMBL" id="PCH42856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="169" mass="18830" checksum="543880B9A4E9003F" modified="2018-01-31" version="1">MSIAAEEMKFYGGTIAQTIYYYQAYLQDSIKLKSLVLMNYDIPQMLWEAVVVSHTDMATALTWVVSILHICIMETSAIARDVSPYILMQNAVIRNKAIRNILTIVATRILKGLVKDLRVTIHDKATTSAIQLIQIILYELGPRKTFGGNASNLTYFVASSVNVNSVLIA</sequence>
</entry>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Barry K."/>
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                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
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                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
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                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
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                <person name="Larrondo L.F."/>
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                <person name="Ling A."/>
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                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
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                <person name="Wiebenga A."/>
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                <person name="Eastwood D.C."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
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        </location>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="316" mass="34425" checksum="6AE4CC6F49621B7A" modified="2018-01-31" version="1">MSAHFPRRRLDLGRGSRAHGYSIAVPLSYIAPARRDTGAAHTVRAYLVLAVPRQTSHLRITYDVHSIPHTPFSALAFPPRTATVAHRAHAPRPGRTRGLPRGRTSTHADTHCRGLRANLSNKCHAAVSIHTLHGGTRHLDRRKQEQDRGRSKAQQERDVEGKAAGAPRGRNAARRGEKGRRAGEALPALGGSRILSCAPAERVTASLQIARRRVARTGAREERGSSHARVRAPTGVGSQVMRCWAQRFQDKTGQRLGPRCQTRSTDEAVPVLRCEEGEAICQESFAGARAISAIADGSMGSVMYVVHSRRVYGIVV</sequence>
</entry>
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            <fullName evidence="2">Uncharacterized protein</fullName>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
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                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
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                <person name="Benoit I."/>
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                <person name="Ferreira P."/>
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                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
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                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
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                <person name="Ling A."/>
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                <person name="Martin R."/>
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                <person name="Morgenstern I."/>
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                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
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                <person name="Sabat G."/>
                <person name="Salamov A."/>
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                <person name="Stenlid J."/>
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                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
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                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="73"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH40863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="104" mass="11224" checksum="8A2306AE40CDE28C" modified="2018-01-31" version="1">MSVVSSTMTFTDVLPDDASEDELFFRAILAIAAADEVRRGLVDAALMSGGYSPDAWHHSKLFELSLAAHGGRQTMEERVGGDPPSGKENLAGCVRREDETPMRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JM94</accession>
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    <protein>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
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                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
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                <person name="Hori C."/>
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                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
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                <person name="Kumar T.K.A."/>
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                <person name="Lindquist E."/>
                <person name="Ling A."/>
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                <person name="Morgenstern I."/>
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                <person name="Ohm R.A."/>
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                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
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        </citation>
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            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
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                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the synthesis of activated sulfate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>adenosine 5'-phosphosulfate + ATP = 3'-phosphoadenylyl sulfate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24152"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the APS kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.25" evidence="4 11"/>
    <dbReference type="EMBL" id="KB468146">
        <property type="protein sequence ID" value="PCH43686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JND0"/>
    <dbReference type="STRING" id="742152.A0A2H3JND0"/>
    <dbReference type="OMA" id="HENTVEE"/>
    <dbReference type="OrthoDB" id="506431at2759"/>
    <dbReference type="UniPathway" id="UPA00140">
        <property type="reaction ID" value="UER00205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004020">
        <property type="term" value="F:adenylylsulfate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019344">
        <property type="term" value="P:cysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070814">
        <property type="term" value="P:hydrogen sulfide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02027">
        <property type="entry name" value="APSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000212">
        <property type="entry name" value="Adenylyl-sulfate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00065">
        <property type="entry name" value="Adenylyl_sulf_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002891">
        <property type="entry name" value="APS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059117">
        <property type="entry name" value="APS_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00455">
        <property type="entry name" value="apsK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003013">
        <property type="entry name" value="PRK03846.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11055">
        <property type="entry name" value="BIFUNCTIONAL 3'-PHOSPHOADENOSINE 5'-PHOSPHOSULFATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11055:SF1">
        <property type="entry name" value="PAPS SYNTHETASE, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01583">
        <property type="entry name" value="APS_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="8 11 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APS kinase" evidence="12">
        <location>
            <begin position="24"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PCH43686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="199" mass="22287" checksum="828B30BA2C99B57A" modified="2018-01-31" version="1">MATNIVFHKGSVDTAERAQLLQQKGVTIWFTGLSASGKSTIACALEQHLLHLHKFCYRLDGDNIRFGLNKDLGFDEKSRTENIRRIGEVSKLFADASCIAVTAFISPYRVDRQVARELHEKAGLAFVEVFVDAPLHVVEARDPKGLYKKARAGEIKDFTGISAPYEAPENPELRIKTDEYDVAESVRVITEYLTQKGFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JNU2</accession>
    <name>A0A2H3JNU2_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ARM repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_163213</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TTI2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH41573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JNU2"/>
    <dbReference type="STRING" id="742152.A0A2H3JNU2"/>
    <dbReference type="OMA" id="PMASQDY"/>
    <dbReference type="OrthoDB" id="6417021at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110078">
        <property type="term" value="C:TTT Hsp90 cochaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018870">
        <property type="entry name" value="Tti2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32226">
        <property type="entry name" value="TELO2-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32226:SF2">
        <property type="entry name" value="TELO2-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10521">
        <property type="entry name" value="Tti2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="120"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="120"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH41573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="436" mass="48127" checksum="74E6DB13A66A4973" modified="2018-01-31" version="1">MSDSGGSSLRVVLEQLKVPSDFAQYDKITEVDIIVCLEEWKRRADSVLSDVRAHLRKRDDLSTTENADVVSFVVPLAADGPWTSDAAREQAQEILLPYALPDASILQDILSRHVKPIFQSNTHPSLNPSSGRTLPRPAGGPLAQSSHLEGQVWKEHPGIADLVSWCVQRCESNLYEKLWHLIIPPVMTLLDDFEPPYKLHGINIVSDMLVKVPADLLRRTGVDGLLFTSLKTCLTFLHNPETPDLLRAATRTLITLVLLTTSAGSARRFDQLCAILGDGIIGNVWLYATRESDAIEASLDVLPEVVQALGIGAARYLKAIIPQLVHPLLPSPENAASRRFQLASVRALSLAIRTCAPRMFKWKDTILEGVLKCWVSIVDEGGSDDHIEELKRALGEVCRCLLDACPSLREEEYARLVQMDANMFGPLLASSIDCFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JP49</accession>
    <name>A0A2H3JP49_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-galactosidase</fullName>
            <ecNumber evidence="3">3.2.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WOLCODRAFT_67483</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyl hydrolase 35 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="3"/>
    <dbReference type="EMBL" id="KB468053">
        <property type="protein sequence ID" value="PCH40579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JP49"/>
    <dbReference type="STRING" id="742152.A0A2H3JP49"/>
    <dbReference type="OMA" id="GHEAAIY"/>
    <dbReference type="OrthoDB" id="1657402at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000040">
        <property type="entry name" value="Beta-galactosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.20.10">
        <property type="entry name" value="Beta-galactosidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.390.10">
        <property type="entry name" value="Beta-galactosidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018954">
        <property type="entry name" value="Betagal_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037110">
        <property type="entry name" value="Betagal_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025972">
        <property type="entry name" value="BetaGal_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036833">
        <property type="entry name" value="BetaGal_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025300">
        <property type="entry name" value="BetaGal_jelly_roll_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031330">
        <property type="entry name" value="Gly_Hdrlase_35_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001944">
        <property type="entry name" value="Glycoside_Hdrlase_35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23421">
        <property type="entry name" value="BETA-GALACTOSIDASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13364">
        <property type="entry name" value="BetaGal_ABD2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10435">
        <property type="entry name" value="BetaGal_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13363">
        <property type="entry name" value="BetaGal_dom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01301">
        <property type="entry name" value="Glyco_hydro_35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00742">
        <property type="entry name" value="GLHYDRLASE35"/>
    </dbReference>
    <dbReference type="SMART" id="SM01029">
        <property type="entry name" value="BetaGal_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117100">
        <property type="entry name" value="Beta-galactosidase LacA, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013957759" description="beta-galactosidase" evidence="9">
        <location>
            <begin position="28"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-galactosidase" evidence="10">
        <location>
            <begin position="413"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PCH40579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="1019" mass="110971" checksum="1C588BEB49F14EBE" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JPN7</accession>
    <name>A0A2H3JPN7_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidase S54 rhomboid domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WOLCODRAFT_123083</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S54 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468157">
        <property type="protein sequence ID" value="PCH44142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JPN7"/>
    <dbReference type="STRING" id="742152.A0A2H3JPN7"/>
    <dbReference type="OMA" id="DTHITLI"/>
    <dbReference type="OrthoDB" id="10260614at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050925">
        <property type="entry name" value="Rhomboid_protease_S54"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43731:SF14">
        <property type="entry name" value="PRESENILIN-ASSOCIATED RHOMBOID-LIKE PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43731">
        <property type="entry name" value="RHOMBOID PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="8">
        <location>
            <begin position="93"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PCH44142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="308" mass="33536" checksum="3CD57EB2B92790DD" modified="2018-01-31" version="1">MRKASYRELGRKLQARLTQFQEAVSGLPQDIRAMAVYSYAQVAQSILNTTEGSRMCYAIGALNGAILLAWQIPRLTPVMMRAFTHSPLSGLSYTMLTCVFSHSSFLHYLFNTMALASFGSAATSYLTTKQQEPGHLRESTSKWHFLAFFVSAGLFSSAVSHVITARITYPQLVSRLTRLAPSLTSGTFSSASTAARSSTAAAEIASTIKPSLGASGAIYATVTLTAMAYPDTHITLIFPPTPPIPIQYGVFGLMAVDVLGILRGWKLFDHYAHLGGALFGIWYHAYGPQIWESFRVMTLGSLPPSLYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JPS2</accession>
    <name>A0A2H3JPS2_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_24277</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH40799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JPS2"/>
    <dbReference type="STRING" id="742152.A0A2H3JPS2"/>
    <dbReference type="OMA" id="WMSAINE"/>
    <dbReference type="OrthoDB" id="1716625at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
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        </location>
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        </location>
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        <location>
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            <end position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH40799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="702" mass="76540" checksum="08FA6C1E884DDC74" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JQ11</accession>
    <name>A0A2H3JQ11_WOLCO</name>
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        <submittedName>
            <fullName evidence="12">Nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">NBP35</name>
        <name evidence="12" type="ORF">WOLCODRAFT_77303</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="12 13">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NBP35-CFD1 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NBP35 subfamily.</text>
    </comment>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="NUBP1/Nbp35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264:SF35">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
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    </dbReference>
    <dbReference type="PROSITE" id="PS01215">
        <property type="entry name" value="MRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 10" id="KW-0408">Iron</keyword>
    <keyword evidence="9 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
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        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
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            <label>1</label>
        </ligand>
    </feature>
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        <location>
            <position position="41"/>
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        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
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        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="78"/>
            <end position="85"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>ligand shared with heterodimeric partner</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>ligand shared with heterodimeric partner</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PCH44246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
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    </evidence>
    <sequence length="349" mass="37572" checksum="B5AE562F928C4300" modified="2018-01-31" version="1">MIALQQSAPAPDPLSVPSNAPEHCPGTESELAGKADACAGCANQEICASGQARGPDPALPLVRQRMSSVRRKILVLSGKGGVGKSTFTAQLGWAFAADEQLQTGIMDVDICGPSIPTILGIASEQVHASSSGWSPVYVQDNLGVMSVGFMLPSSKDAVMWRGPKKNGLISQFLKDVDWGELDYLVIDTPPGTSDEHLSIVQYLKESGIDGAIVITTPQEVALQDVRREIDFCRKVGIRVLGLVENMSGFVCPNCKNESQIFKPSTGGGRRLAQDMGVDFLGAVPLDPRIGKSADYGISFLDEYPDSPASAAYLDIIDREFSIFRCLLFEKSHVHRDQAKARKLSRSHIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JQ57</accession>
    <name>A0A2H3JQ57_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">WOLCODRAFT_26467</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
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                <person name="St John F."/>
                <person name="Stenlid J."/>
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                <person name="Sun S."/>
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                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
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                <person name="Cullen D."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <end position="26"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH44041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="59" mass="6373" checksum="13CA4F8379318907" modified="2018-01-31" version="1">MALDRAWRMDTGGDPTERGPAPLRPPFGRFLVTRSHHSPLSHGALASCLCIRLPGAAHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JQI2</accession>
    <name>A0A2H3JQI2_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_24469</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH41069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JQI2"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH41069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="154" mass="16566" checksum="B33264D15425306F" modified="2018-01-31" version="1">MSCGVSTQGHVSRPRCARKSWPVPATTTSGRGSRSRMHAPGRKQPLSLHADGGADEVECRCPNFGRPSIRSVRTPPSPRPRWQMALGTQLARTEQIFQWDDLLKCAGCVLQCPRSSPSTDEASGGAASYGWHAASKCDMSIHAKGHSINILPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JRG6</accession>
    <name>A0A2H3JRG6_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WOLCODRAFT_139049</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468157">
        <property type="protein sequence ID" value="PCH44521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JRG6"/>
    <dbReference type="STRING" id="742152.A0A2H3JRG6"/>
    <dbReference type="OMA" id="WAVMNIE"/>
    <dbReference type="OrthoDB" id="2432613at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018466">
        <property type="entry name" value="Kre9/Knh1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052982">
        <property type="entry name" value="SRP1/TIP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40633:SF1">
        <property type="entry name" value="GPI ANCHORED SERINE-THREONINE RICH PROTEIN (AFU_ORTHOLOGUE AFUA_1G03630)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40633">
        <property type="entry name" value="MATRIX PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05410)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10342">
        <property type="entry name" value="Kre9_KNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013857299" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="363"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal" evidence="4">
        <location>
            <begin position="25"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PCH44521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="383" mass="36961" checksum="0332D5FA165763A3" modified="2018-01-31" version="1">MYTPLLLTALFLGAARVRADPTPTTPSPGAVYNEGAQCSVAWDADTSGIWAVMNIELMTGDNEQMQFLETVGTVDATTTSSYTYTCPSVSPNAQIYFYQFTSPYSKNVYWTGRFAIADANGATVPPTETELFDGTTVLWGSGSVVGVVPTAAPQYGQSVGAAHSSAVASSAPASSTVEVTSSAAAPSSSAAASSAAASSAAATSSVATSSSSVAPSTSASSSAAVSSSAAASSSAPAVASSSASAVASTSASASASASVPVSSSVALSISAPVSSVSSSSAASSSVIPSTSSTESVSSTSVLSSSAVAPTFVAVTTTSSSRISTVVVTVPTSTATESASGSATQNAGSGASANAALGTLRIDAHVFGGVLALGIAALAFGVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JRQ5</accession>
    <name>A0A2H3JRQ5_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 12">Nicotinate-nucleotide pyrophosphorylase [carboxylating]</fullName>
            <ecNumber evidence="5 12">2.4.2.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 12">Quinolinate phosphoribosyltransferase [decarboxylating]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">WOLCODRAFT_69319</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 12">Involved in the catabolism of quinolinic acid (QA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>nicotinate beta-D-ribonucleotide + CO2 + diphosphate = quinolinate + 5-phospho-alpha-D-ribose 1-diphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:12733"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29959"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from quinolinate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 12">Hexamer formed by 3 homodimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the NadC/ModD family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.19" evidence="5 12"/>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH41469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JRQ5"/>
    <dbReference type="STRING" id="742152.A0A2H3JRQ5"/>
    <dbReference type="OMA" id="DIVMCDN"/>
    <dbReference type="OrthoDB" id="10067394at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00331"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004514">
        <property type="term" value="F:nicotinate-nucleotide diphosphorylase (carboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034213">
        <property type="term" value="P:quinolinate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01572">
        <property type="entry name" value="QPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000090">
        <property type="entry name" value="Nicotinate-nucleotide pyrophosphorylase [carboxylating]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.20">
        <property type="entry name" value="Quinolinate phosphoribosyl transferase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004393">
        <property type="entry name" value="NadC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027277">
        <property type="entry name" value="NadC/ModD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037128">
        <property type="entry name" value="Quinolinate_PRibosylTase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002638">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022412">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00078">
        <property type="entry name" value="nadC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32179">
        <property type="entry name" value="NICOTINATE-NUCLEOTIDE PYROPHOSPHORYLASE [CARBOXYLATING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32179:SF3">
        <property type="entry name" value="NICOTINATE-NUCLEOTIDE PYROPHOSPHORYLASE [CARBOXYLATING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01729">
        <property type="entry name" value="QRPTase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02749">
        <property type="entry name" value="QRPTase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006250">
        <property type="entry name" value="NadC_ModD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="Nicotinate/Quinolinate PRTase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54675">
        <property type="entry name" value="Nicotinate/Quinolinate PRTase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 12" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Quinolinate phosphoribosyl transferase N-terminal" evidence="14">
        <location>
            <begin position="48"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="Quinolinate phosphoribosyl transferase C-terminal" evidence="13">
        <location>
            <begin position="114"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR006250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PCH41469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="296" mass="32662" checksum="1C03ACD77D3BA280" modified="2018-01-31" version="1">MSHSYEHLLPPSWKPQVTAWLTEDTPSFDYGGFVVGEAHREAYLLGKGKETAVLAGVPFFTEVFAQLGCEVEWHIQEGETFEPVKHVATVRGKVRHLLLGERVALNMLARCSGIATKSKRIQDIARGYGYKGIIAGTRKTTPGFRLVEKYGMLVGGIDPHRHDLSSMIMLKDNHIWSSGSITNAIEAARKVGGFSLLLEVEVGSEAEADEAIDAGADIIMLDNMEGDELVSVARKLKEKWSGKRKFLFESSGNITESNLRERAINEIDILSTSSVHQSVQHIDFSLKIQVPKAETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JRT4</accession>
    <name>A0A2H3JRT4_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_149656</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH38717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JRT4"/>
    <dbReference type="OMA" id="FIAHEIT"/>
    <dbReference type="OrthoDB" id="2804352at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF17">
        <property type="entry name" value="FUNGAL STAND N-TERMINAL GOODBYE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="NACHT" evidence="2">
        <location>
            <begin position="137"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH38717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="619" mass="69849" checksum="FF9113D219FCBFBA" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JRW2</accession>
    <name>A0A2H3JRW2_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WOLCODRAFT_145226</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="KB468168">
        <property type="protein sequence ID" value="PCH44896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JRW2"/>
    <dbReference type="STRING" id="742152.A0A2H3JRW2"/>
    <dbReference type="OMA" id="HTYEDFY"/>
    <dbReference type="OrthoDB" id="420187at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF888">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="9">
        <location>
            <begin position="32"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="169"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="263"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="477"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="607"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="305"/>
            <end position="327"/>
        </location>
    </feature>
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        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
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    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
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                <person name="Morin E."/>
                <person name="Murat C."/>
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                <person name="Nolan M."/>
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<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
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    <sequence length="449" mass="48453" checksum="C9C79A37FD894F84" modified="2018-01-31" version="1" fragment="single">MAWKVRPSMLFSPPPLRLDKRKRMPSIVASDDEDTHVPGDGSQATYRRRMHPAPLEMLKLKRRLKEAGKRKLEGMVPKFLRRSPRSVPKPRLPKSNDVKAQRKLFVPYSIRWRPMPIAKKSSKPMSEAGGSEAVQDKKRVRKFVLRKARHLRRFSGASNIPVVKSEMAEASTPTLPNAAQGPCDQDVLYESSAGDDKTIVCSEDRSEGSVSETLSVNVSIVSFDEADSNLKHSAADSDNDTLVDDTSVISISEDLFERNDSGAMVAEEVKKALGIEVVVRDAERGVPAQAEQVENEVVAAMGEGDAHNEEGVVAEADSLTAGATELESNADVEEGDIAEEPSAVGEVHHTVNDALVSCDSLSLSLAEGPSGGPSDIADSSEQHEATSSQLPETQLEAGPAQDDSEDNALLVGEDDDDMHAEIDSARMEELSFDSLPVPANPATAPEAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JTC5</accession>
    <name>A0A2H3JTC5_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L36</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WOLCODRAFT_137183</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL36 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH41088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JTC5"/>
    <dbReference type="STRING" id="742152.A0A2H3JTC5"/>
    <dbReference type="OMA" id="NKGHKTE"/>
    <dbReference type="OrthoDB" id="9616667at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1760:FF:000003">
        <property type="entry name" value="60S ribosomal protein L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1760">
        <property type="entry name" value="60S ribosomal protein L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000509">
        <property type="entry name" value="Ribosomal_eL36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038097">
        <property type="entry name" value="Ribosomal_eL36_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10114">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01158">
        <property type="entry name" value="Ribosomal_L36e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01190">
        <property type="entry name" value="RIBOSOMAL_L36E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PCH41088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="101" mass="11714" checksum="FDF0E8EB04DCDE49" modified="2018-01-31" version="1">MARSNLRYGLKKGHPTTPIAKTVRPSQRKGILSARTKFVRSIVREVAGFSPYERRIMELLRNSKDKKARKLTKKRLGTLLRSKRKLEELSTIIQESRRTGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JTH3</accession>
    <name>A0A2H3JTH3_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WOLCODRAFT_78291</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="2"/>
    <dbReference type="EMBL" id="KB468168">
        <property type="protein sequence ID" value="PCH44865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JTH3"/>
    <dbReference type="STRING" id="742152.A0A2H3JTH3"/>
    <dbReference type="OMA" id="ITCRCKT"/>
    <dbReference type="OrthoDB" id="9977870at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22582">
        <property type="entry name" value="BRcat_RBR_unk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22584">
        <property type="entry name" value="Rcat_RBR_unk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="191"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PCH44865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="587" mass="66422" checksum="0795676C48BE4EA5" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JU30</accession>
    <name>A0A2H3JU30_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6589 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_77838</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468168">
        <property type="protein sequence ID" value="PCH45075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JU30"/>
    <dbReference type="STRING" id="742152.A0A2H3JU30"/>
    <dbReference type="OMA" id="NITHRVF"/>
    <dbReference type="OrthoDB" id="2742682at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046496">
        <property type="entry name" value="DUF6589"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20231">
        <property type="entry name" value="DUF6589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6589" evidence="1">
        <location>
            <begin position="88"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH45075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="334" mass="38166" checksum="CFCBFCD540295192" modified="2018-01-31" version="1">MNQSWVYDALDTLAVLVHKAMLNDIKNYPWFGSHDNLNITHRVFEQRLSNQSHFDSGTAGTIFVVKDPSTVRLNSRELQAQIALGSKSLITLEEIYALNSVAGPRIHQRAVYKVLSILINSPGFDFESYTLRGDPLFEPLPPVQQLPTGPNSATTQYMLNTVHIEEASYEGNLRLLEEWFRQLRITSQDEQIKFAIDNVLIWIGDQLTTSRLRGNQKYRCEDHNSWDCIEYLVKQIGFFHAQMAQEHSIHEQHYGTSKGRGLAFAFNLLNRRGLSKPSIKGTFHHHLQEGLLHVSEALFHDLWCVLGRVDSLEKLRLCSPAELYALAERIVLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JVF7</accession>
    <name>A0A2H3JVF7_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA recognition motif spliceosomal PrP8 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_18005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468135">
        <property type="protein sequence ID" value="PCH42889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JVF7"/>
    <dbReference type="STRING" id="742152.A0A2H3JVF7"/>
    <dbReference type="OrthoDB" id="3258820at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097157">
        <property type="term" value="F:pre-mRNA intronic binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030619">
        <property type="term" value="F:U1 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030620">
        <property type="term" value="F:U2 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030623">
        <property type="term" value="F:U5 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027652">
        <property type="entry name" value="PRP8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019582">
        <property type="entry name" value="RRM_spliceosomal_PrP8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11140">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR PRP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11140:SF0">
        <property type="entry name" value="PRE-MRNA-PROCESSING-SPLICING FACTOR 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10598">
        <property type="entry name" value="RRM_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA recognition motif spliceosomal PrP8" evidence="1">
        <location>
            <begin position="235"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH42889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="405" mass="45585" checksum="654FED1BE27575AE" modified="2018-01-31" version="1">MFCQVIPTQFSNEQTMILSLGEQEDTLGVFRETHSNNIPLTATLTWVLRGDLDEIIPLTDAEYPAFKKAVHSKDIHTLHVTINNQAEAYKDQAEAQENPYQALVEKAYKACQEEMVLALAHHNIDKATVTKTLGHLTHLLKTEPEMQCGYLKDGPYISAEEAVTIYAATIHWLKSRKFLSIPFPLLNYKHNRKLLVLTFEKVKEAYSVKGHPNQSQREKLLLIEQAYDNAHECFSRIKCLLLTQRAHSRSISKNDTLLTYKDMAHTNACDLICGLQFTAFVFQYYGLVLDLLILGLQRASETASPPQMPTKILQYRDCATEAPSNSIVLSLRRQAPHSFDSSQKIRVTIKSKLAETMVHTARMRSSSETSTSIYPSSVKDGQTKCGSAIVFLSGQRTILAFSLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JVH0</accession>
    <name>A0A2H3JVH0_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_152954</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468135">
        <property type="protein sequence ID" value="PCH42899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JVH0"/>
    <dbReference type="STRING" id="742152.A0A2H3JVH0"/>
    <dbReference type="OMA" id="YKSWEVA"/>
    <dbReference type="OrthoDB" id="2310150at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19075">
        <property type="entry name" value="AKR_AKR7A1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF4">
        <property type="entry name" value="NAD(P)-LINKED OXIDOREDUCTASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="10"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH42899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="339" mass="38597" checksum="C46267060F51E2CC" modified="2018-01-31" version="1">MATQKSALNIVMGAMTFGEEGKEGARVYDIKDVEAILDVFQAHGHTEIDSARTYTGGTSEAYLGRINWRERGLKLETKLYPNVSNKRLQNPNRSLISHSPEDLRRHLEISMKALNTDQLEMWYLHGPDRTTPYEVTLKAVNELYKEGKFKRFGISNYMAWEVAEIVQICRANGYIQPTAYQGIYNAIHRKVEPELFPCLRKYGISFYEFNPLGGGFFTGRYASLDEKVEPGSRFDPEKGQGRNYRARYWNEPYFNAITAIQEVATAHGLTMAEIALRWISHHSLMKREYGDAVIIGASSLTHIEQNLVDLEKGPLPDTVVKALDDAWLSVAPYATNYFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JW04</accession>
    <name>A0A2H3JW04_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycoside hydrolase family 128 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WOLCODRAFT_137654</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">MD-104</strain>
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    </evidence>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
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                <person name="Nagy L.G."/>
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                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
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    </dbReference>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH43779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="342" mass="37448" checksum="2AD507E860C78A49" modified="2018-01-31" version="1">METSAGLPLLLALGARIVLNTLYPGHATLAPTHEYILTGIFEGALLYTVLYSFSVLSIPVGAGIAAKLLLDYFRTFDTTQSICTLSGIALGTIFSDALSRAFEGDTITTVTTRERVTTHARAAHEPSKRIRLVSFERDRTRTHRNHHDAADDGQQPQPAPPRAPTSAQTHASTAPSISLDSVPSSIDPEGRMTPRERAVAVLRARASLADSERRRFKEERKWALSQGNFARANQLAWQVKRYTTLMESFHREADAMVVEAARVASGTQSELLVERTRRTSQTQRRQAGQSTVPFPGQSTTPAPAEQAPLVSVTVGTSRSRRRSSGTIRPAIHVQGREVSTKR</sequence>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
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                <person name="Benoit I."/>
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                <person name="Hesse C."/>
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                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
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                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
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                <person name="Pisabarro A."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="68" mass="7727" checksum="53DA59E2A6CAE3D5" modified="2018-01-31" version="1">MSPCEVVEKNGWGPCHQHRHIRDTVRIGTAPYLRAHLAALEHGNVGLKRRGSYFAFTYCSLGTCLTRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JZT2</accession>
    <name>A0A2H3JZT2_WOLCO</name>
    <protein>
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    </protein>
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        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
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            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
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                <person name="St John F."/>
                <person name="Stenlid J."/>
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                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JZT2"/>
    <dbReference type="Proteomes" id="UP000218811">
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH43388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="183" mass="19398" checksum="D9CFE542AEADEBA4" modified="2018-01-31" version="1">MACKLPSSAMRSNTSSTRHFSLDVVQITVCILHAQSAHATVAGERFWAATSLATPSRVLLRAGDAPSVSTLVFVSLNSLLRVATTLGLHGPVAIRHRGGSCPGRYVCSQLWPTDGLVGRVMDHNRHSHFGAGTTRWWSIVRRGSAASPPASPGSCSQRNVAPDSGHRDLSAFSDIGCRAKVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K041</accession>
    <name>A0A2H3K041_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="2" type="ORF">WOLCODRAFT_152400</name>
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        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
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        <lineage>
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            <taxon>Phaeolaceae</taxon>
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468124">
        <property type="protein sequence ID" value="PCH42374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K041"/>
    <dbReference type="Proteomes" id="UP000218811">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="194"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="226"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH42374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="289" mass="30668" checksum="32CE23F6BF3139CD" modified="2018-01-31" version="1">MASTSAPDATPALGDTDWEFPEGSAAQNPDPLQSFVASPQAVMTLSLRTWSPCRRRARAVLLSEPSTSDKLLISSAEKTRASSVLNLNQERALHNRIRIHEAKGAQLTGTSYDLSTRPITHTGCSEFMKPARRAATGGETTPRGARSTRRAAAPAHSYNPHTRSDTASHYASRLPPASLAPRTAALLSLQAQTRRLTEPDASAAAERRSPLQTRPRPHHSRDRRQTRLTGRPPPGTTTENCDKFAAVLGPGINGGGSVGTHKGAADAAGLAESQMGPRSGLPLCVPLAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K060</accession>
    <name>A0A2H3K060_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Beta-xylanase</fullName>
            <ecNumber evidence="10">3.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WOLCODRAFT_103625</name>
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    <organism evidence="13 14">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
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            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-xylosidic linkages in xylans.</text>
            <dbReference type="EC" id="3.2.1.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan degradation; xylan degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the glycosyl hydrolase 10 (cellulase F) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.8" evidence="10"/>
    <dbReference type="EMBL" id="KB468146">
        <property type="protein sequence ID" value="PCH43498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K060"/>
    <dbReference type="STRING" id="742152.A0A2H3K060"/>
    <dbReference type="OMA" id="YLRGHNC"/>
    <dbReference type="OrthoDB" id="3055998at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031176">
        <property type="term" value="F:endo-1,4-beta-xylanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044846">
        <property type="entry name" value="GH10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001000">
        <property type="entry name" value="GH10_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490:SF35">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00331">
        <property type="entry name" value="Glyco_hydro_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00134">
        <property type="entry name" value="GLHYDRLASE10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00633">
        <property type="entry name" value="Glyco_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51760">
        <property type="entry name" value="GH10_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 10 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013870835" description="Beta-xylanase" evidence="11">
        <location>
            <begin position="22"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="GH10" evidence="12">
        <location>
            <begin position="46"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PCH43498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="356" mass="38879" checksum="8D88A350ED7973FD" modified="2018-01-31" version="1">MPLSLAFVTISAFIAAHTVSALPQATSTSSTLPTATSVVKGLNYLARNAGKLYFGTATDNSELNDTTYTGIMDNYLHFGQLTPENSMKWDATEPEPGVFTFAAGDVIANLAKSYGMYLRGHNCVWYEQLPDWVTVNNYNATGLTAVVENHVSTLVGHYADAWDVINEPLNDNGTFREDVFYNTLGTEYIPIALKAARAADPNAKLYINDYNIEYVGTKSTALQNLIKELQADGVPIDGVGMESHFIVGEVPTTLVENFQAYADLGLEFAITELDIRMELPETAALLEQQKTDFYTVVNACLSVSACKGVTVWDWTDKYSWIPSTFPGYGAACPWDANFVRKPAFDGIAIAFEGGSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K0H0</accession>
    <name>A0A2H3K0H0_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Cysteine proteinase 1, mitochondrial</fullName>
            <ecNumber evidence="2 9">3.4.22.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WOLCODRAFT_103816</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Has aminopeptidase activity, shortening substrate peptides sequentially by 1 amino acid. Has bleomycin hydrolase activity, which can protect the cell from the toxic effects of bleomycin. Has homocysteine-thiolactonase activity, protecting the cell against homocysteine toxicity.</text>
    </comment>
    <comment type="function">
        <text evidence="7">The normal physiological role of the enzyme is unknown, but it is not essential for the viability of yeast cells. Has aminopeptidase activity, shortening substrate peptides sequentially by 1 amino acid. Has bleomycin hydrolase activity, which can protect the cell from the toxic effects of bleomycin. Has homocysteine-thiolactonase activity, protecting the cell against homocysteine toxicity. Acts as a repressor in the GAL4 regulatory system, but this does not require either the peptidase or nucleic acid-binding activities.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Inactivates bleomycin B2 (a cytotoxic glycometallopeptide) by hydrolysis of a carboxyamide bond of beta-aminoalanine, but also shows general aminopeptidase activity. The specificity varies somewhat with source, but amino acid arylamides of Met, Leu and Ala are preferred.</text>
            <dbReference type="EC" id="3.4.22.40"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homohexamer. Binds to nucleic acids. Binds single-stranded DNA and RNA with higher affinity than double-stranded DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.22.40" evidence="2 9"/>
    <dbReference type="EMBL" id="KB468146">
        <property type="protein sequence ID" value="PCH43598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K0H0"/>
    <dbReference type="STRING" id="742152.A0A2H3K0H0"/>
    <dbReference type="OMA" id="QSYTFFW"/>
    <dbReference type="OrthoDB" id="2666448at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070005">
        <property type="term" value="F:cysteine-type aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043418">
        <property type="term" value="P:homocysteine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009636">
        <property type="term" value="P:response to toxic substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00585">
        <property type="entry name" value="Peptidase_C1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004134">
        <property type="entry name" value="Peptidase_C1B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10363">
        <property type="entry name" value="BLEOMYCIN HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10363:SF2">
        <property type="entry name" value="BLEOMYCIN HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03051">
        <property type="entry name" value="Peptidase_C1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005700">
        <property type="entry name" value="PepC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 9" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0788">Thiol protease</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="421"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR005700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR005700-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PCH43598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="503" mass="55241" checksum="46E959EAF5967A27" modified="2018-01-31" version="1">MGSNNSKPTSSPAAAAHDAAHDEKCAAVDRVAESLSALQLSPASADGSLAAASVAAWEAEVGAQPKARLARAVLHHTSVQTAFVSRAAQVADAHVFNTQLDFKTGPITNQKSSGRCWLFATTNVLRYNIMRKLNLDDFQLSQSYLFFWDKLNKSNYYLELSIQHADLPIDERIVTHTASDLISDGGQWDMVVNILENYGVVPQAVYPESFHSSASAPLNTILKRKLREHALILRSLSASLRADGSLTGDAVLRALRAKKEELMKEVYTVMSASLGVPPPAGETFVWDYYDKDGKAGRWEGTPAQFYKAFAYDKHAPSDSFSLIHDPRNEFGKLYSVDKLGNVWGGRDVLYVNTKIDDLKQAVVKMIKAGQPVFFGCDVGQSLEREGGIMDTAMFEHENAFDITFGLTKADRLRTGESAMTHAMVISGVHLDPATGAPVRYKVENSWGDTSGDKGYYLMTDAWFEQYVFQVVVPKALAPKELVKVYESGEKTLLPLWDPMGALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K139</accession>
    <name>A0A2H3K139_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_74706</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468135">
        <property type="protein sequence ID" value="PCH42734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K139"/>
    <dbReference type="OrthoDB" id="2802569at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH42734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="70" mass="8137" checksum="365F129CF1700DF3" modified="2018-01-31" version="1" fragment="single">HNTDGTYSSNGQLKEVVKAYMIHGKHKETVGLAIMKLHGTDLILGYDWLRRHNPHFNWIKGEMDYSHCKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K1L7</accession>
    <name>A0A2H3K1L7_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">amidase</fullName>
            <ecNumber evidence="3">3.5.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WOLCODRAFT_106066</name>
    </gene>
    <organism evidence="7 8">
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        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7 8">MD-104</strain>
        </source>
    </reference>
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        <reaction evidence="1">
            <text>a monocarboxylic acid amide + H2O = a monocarboxylate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
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            <dbReference type="ChEBI" id="CHEBI:83628"/>
            <dbReference type="EC" id="3.5.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amidase family.</text>
    </comment>
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    <dbReference type="EMBL" id="KB468168">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF10">
        <property type="entry name" value="ACETAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="63"/>
            <end position="533"/>
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        <location>
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        </location>
    </feature>
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        <location>
            <position position="184"/>
        </location>
    </feature>
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        <location>
            <position position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH45079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD-104</strain>
        </source>
    </reference>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF10">
        <property type="entry name" value="PROTEIN N-TERMINAL AND LYSINE N-METHYLTRANSFERASE EFM7"/>
        <property type="match status" value="1"/>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
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        </location>
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            <begin position="1"/>
            <end position="13"/>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
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    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K379</accession>
    <name>A0A2H3K379_WOLCO</name>
    <protein>
        <recommendedName>
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        </recommendedName>
        <alternativeName>
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        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WOLCODRAFT_133308</name>
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    <organism evidence="9 10">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
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    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78479"/>
            <dbReference type="Rhea" id="RHEA-COMP:19087"/>
            <dbReference type="Rhea" id="RHEA-COMP:19089"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:167623"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:78480"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78507"/>
            <dbReference type="Rhea" id="RHEA-COMP:19088"/>
            <dbReference type="Rhea" id="RHEA-COMP:19090"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:167623"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:78508"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78471"/>
            <dbReference type="Rhea" id="RHEA-COMP:19085"/>
            <dbReference type="Rhea" id="RHEA-COMP:19087"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:78472"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78475"/>
            <dbReference type="Rhea" id="RHEA-COMP:19086"/>
            <dbReference type="Rhea" id="RHEA-COMP:19088"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:78476"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. Trimethylguanosine synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468157">
        <property type="protein sequence ID" value="PCH44598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K379"/>
    <dbReference type="STRING" id="742152.A0A2H3K379"/>
    <dbReference type="OMA" id="RYFSLYD"/>
    <dbReference type="OrthoDB" id="194443at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071164">
        <property type="term" value="F:RNA cap trimethylguanosine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000432">
        <property type="entry name" value="Unplaced genomic scaffold supercont2.10, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019012">
        <property type="entry name" value="RNA_cap_Gua-N2-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14741">
        <property type="entry name" value="S-ADENOSYLMETHIONINE-DEPENDENT METHYLTRANSFERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14741:SF32">
        <property type="entry name" value="TRIMETHYLGUANOSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09445">
        <property type="entry name" value="Methyltransf_15"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="18"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="208"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="248"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PCH44598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="385" mass="41824" checksum="7764FF086A51E171" modified="2018-01-31" version="1">MGKKHAISGLSRFVSEAFSSTTPVAEDTSDKSADATADSAVAGTSRTVSSRKDDSTEMQQRPSKRRKVGLLGTGNEKYDATGLVPFYTHASEVPSHLQKYFSQRERYFSLYSSGCLLDEEGWYSVTPERIADQIAERCRCDVVLDAFCGVGGNAIAFARTCERVIALDTSPVRLALARHNAALYGVADRIEFVLADFLSFARTLAQFPHSPPSATTASSARDDSSSPPPTSRKIDVVFLSPPWGGPSYLTDSPSADTPHPSTEEVEEGAETTPSEYSLASIRPVHGRELFQLARKITRNVAYFLPRNMNLQEVAALVAEGGHDAAEANADGEAASVRKAKNRKGKGKKNEVEMVEVEEEWMGNKLKALTCYFGGLVAGQEDLFYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K402</accession>
    <name>A0A2H3K402_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Ornithine aminotransferase</fullName>
            <ecNumber evidence="4 9">2.6.1.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WOLCODRAFT_25756</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 2-oxocarboxylate + L-ornithine = L-glutamate 5-semialdehyde + an L-alpha-amino acid</text>
            <dbReference type="Rhea" id="RHEA:13877"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="ChEBI" id="CHEBI:59869"/>
            <dbReference type="EC" id="2.6.1.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-ornithine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.13" evidence="4 9"/>
    <dbReference type="EMBL" id="KB468135">
        <property type="protein sequence ID" value="PCH43157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K402"/>
    <dbReference type="STRING" id="742152.A0A2H3K402"/>
    <dbReference type="OMA" id="RSAWDLC"/>
    <dbReference type="OrthoDB" id="10261433at2759"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00358"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004587">
        <property type="term" value="F:ornithine aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019544">
        <property type="term" value="P:L-arginine catabolic process to L-glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010121">
        <property type="term" value="P:L-arginine catabolic process to proline via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000011">
        <property type="entry name" value="Ornithine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000152">
        <property type="entry name" value="Ornithine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050103">
        <property type="entry name" value="Class-III_PLP-dep_AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010164">
        <property type="entry name" value="Orn_aminotrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01885">
        <property type="entry name" value="Orn_aminotrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986">
        <property type="entry name" value="AMINOTRANSFERASE CLASS III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986:SF18">
        <property type="entry name" value="ORNITHINE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9 11" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9 11" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PCH43157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="472" mass="51150" checksum="49AB609963281FC2" modified="2018-01-31" version="1">MAPAALSQTTEAGTNANAKNSQNQNRKSGGQAQISSAEAIRLEHEYGAHNYHPLPVVIDSARGAKVWDPEGREYIDMLSAYSAVNQGHCHPRIVHTLVEQAQRVTLTSRAFYNSVFPRFAQKITQLFGFDMVLPVNTGAEAVETAIKLARKWGYEKKGIPNGRAIVLGAEGNFHGRTIGVISMSTDPETRSHFGPFLEAVGPTYEDGTDIGTIRFGEIADLERALELHGDRVAAFLVEPIQGEAGINVPPAGYLARVRELCTKHNVLLICDEIQTGLCRTGRMLCYEHDNIRPDIVILGKALSGGVYPVSAVLADKDIMLCIQPGEHGSTYGGNPLGCAVAMTALDVLVEEDLARRADILGQKFRSAVEAIESPLVKAVRGRGLLNAIVIDEAASKNGRSAWQFCLLLKSRGVLAKPTHVNIIRFAPPLVIPEEDLMKAVEIIASCLVDLDQLDDIPGEVESEKGYKDTVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K429</accession>
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            <fullName evidence="2">Uncharacterized protein</fullName>
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        <name evidence="2" type="ORF">WOLCODRAFT_138597</name>
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        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
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            <taxon>Phaeolaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
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        <location>
            <begin position="16"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH43804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="89" mass="9200" checksum="B37877254F27287A" modified="2018-01-31" version="1">MSWDSSACGAVEEEAPTTTGADSEARSGSSAKSGEGHGHAFKTDEEESEDFQEMFGGKLALSDGASSKITNELIWAVAAESQSAPREAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K7R7</accession>
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    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
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        <name evidence="7" type="ORF">WOLCODRAFT_106117</name>
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        <lineage>
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            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
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                <person name="Benoit I."/>
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                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB468168">
        <property type="protein sequence ID" value="PCH45124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF22">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="146"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
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            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
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        </location>
    </feature>
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        </location>
    </feature>
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            <end position="366"/>
        </location>
    </feature>
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        <location>
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            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="452"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="488"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="520"/>
            <end position="538"/>
        </location>
    </feature>
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        <location>
            <begin position="103"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH45124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="548" mass="60381" checksum="EFF70DF40D1C1415" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K8N6</accession>
    <name>A0A2H3K8N6_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Mitochondrial ribosomal protein S5/S7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WOLCODRAFT_139270</name>
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        <name type="common">Brown rot fungus</name>
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            <taxon>Agaricomycetes</taxon>
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            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
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                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS7 family.</text>
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    <dbReference type="EMBL" id="KB468168">
        <property type="protein sequence ID" value="PCH44817.1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <location>
            <begin position="84"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PCH44817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="229" mass="25210" checksum="1CA8A2D1C13599C5" modified="2018-01-31" version="1">MLSGLRHGVCRTLLQTRRGFATSTESANAMADSALEAMNSILNGEPFKFTPTSTSTASATPPAPAPRKLFNTGPPSEINIPPAEDPLLAYLTAIIQRHGYRQKAARTTTRVLLHIHTLTRAPPLPILRHAVQSVAPAIRNISNKHAGKTVVYPVPLSEKQRTRIALTWILQASENKSGHRLEERLAREIIAVCQGAGKERPDEWSVAYKKKEEVHKYAMMNRGNAGRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2024-01-24" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IS92</accession>
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        <name type="common">Brown rot fungus</name>
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        <lineage>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH32950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3IS92"/>
    <dbReference type="STRING" id="742152.A0A2H3IS92"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH32950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="112" mass="12454" checksum="1E3AA125D50DC9F5" modified="2018-01-31" version="1">MPPPPDIFTAMLSFILCTLDPTCLTELINALLSMGATAVQLANACLIHLITTLLLTDDMLKVLPAALIMPTWAEHSWGAAYFTNHSCKFHTNLISQLFKFMWDADSVDKEKK</sequence>
</entry>
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    <accession>A0A2H3IST4</accession>
    <name>A0A2H3IST4_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">UvrD-like helicase ATP-binding domain-containing protein</fullName>
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    <gene>
        <name evidence="8" type="ORF">WOLCODRAFT_62498</name>
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        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH33046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="742152.A0A2H3IST4"/>
    <dbReference type="OMA" id="CRNPHGM"/>
    <dbReference type="OrthoDB" id="3156807at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039904">
        <property type="entry name" value="TRANK1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21529">
        <property type="entry name" value="MAMMARY TURMOR VIRUS RECEPTOR HOMOLOG 1, 2 MTVR1, 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21529:SF4">
        <property type="entry name" value="TPR AND ANKYRIN REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="7">
        <location>
            <begin position="497"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="170"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="244"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1955"/>
            <end position="1976"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="172"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1962"/>
            <end position="1974"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="518"/>
            <end position="525"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PCH33046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="2199" mass="250097" checksum="7D585B2810C8FBDC" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3ITA2</accession>
    <name>A0A2H3ITA2_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_159913</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
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                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCR4/nocturin family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH33766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="428734at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050410">
        <property type="entry name" value="CCR4/nocturin_mRNA_transcr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121">
        <property type="entry name" value="CARBON CATABOLITE REPRESSOR PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121:SF45">
        <property type="entry name" value="NOCTURNIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="4">
        <location>
            <begin position="60"/>
            <end position="430"/>
        </location>
    </feature>
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        <location>
            <begin position="16"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PCH33766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="442" mass="49477" checksum="20E7673E0A69967F" modified="2018-01-31" version="1">MSKKFQPTAEQLALAEDRRLKKEQRKQAAEKEEGRILPREWTSVQGASGPENAGQKVRLMTWNLLAQCLVRRELFPTSDCLKASQREHMMYREVFSHDADICCLQEVDRLGKLLPALEQAGYAHVYAAGPRKKHGCLIAYRTSAYTLVEHKMMEYDLQDVRENGTEAARRGSSFRTKNIASMARLKRIHAASEGVIVATTHLFWHPKYTYERARQAAILLREVVRFRNEGPDEHRAWPCIIAGDFNFQPDDPAYSLMVGDPLLPIQEQMMETSRVVHVTIDPNVPATSDKPSAEEEDGAEVGAADPDRVITNARTAVPSDGLLTNSELAKIFRQSGTPTSVYDEAQRLVSTATSETGLTFGSRVSIVPPRRGAFEPIWTSYTHYWKSVLDYIFILSPPGRTAIITTYAKPHAAEALSPGIPRKSVCGSDHISLGAEVYWPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IVF5</accession>
    <name>A0A2H3IVF5_WOLCO</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_61728</name>
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    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Phaeolaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH33956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3IVF5"/>
    <dbReference type="STRING" id="742152.A0A2H3IVF5"/>
    <dbReference type="OMA" id="DYLYYAC"/>
    <dbReference type="OrthoDB" id="423313at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="O-FucT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH33956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="522" mass="59319" checksum="8DFC7E0C00683902" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IW78</accession>
    <name>A0A2H3IW78_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SGS-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_135255</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
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                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OMA" id="KVHMTAD"/>
    <dbReference type="OrthoDB" id="1898560at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="p23_CS_SGT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CS_dom"/>
    </dbReference>
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        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007699">
        <property type="entry name" value="SGS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044563">
        <property type="entry name" value="Sgt1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45862">
        <property type="entry name" value="PROTEIN SGT1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SGS"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51048">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="SGS" evidence="1">
        <location>
            <begin position="104"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH33675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="201" mass="22414" checksum="49E7E13DAA26AF15" modified="2018-01-31" version="1">MTTIRHEFYETDEKLTLSVFDKGADPAQVSVTFRPRSFTYENGDKKLVLEPLKGQIDPEKSDYTVGKVKVEVRLVKVAPGRWSALIGDSPDPLSPFPSSSTTPAVAEARRRHKNWDSVTEAILSSEKNVTSDDDPNAGGDASVNEFFQKLYADADEDTRRAMLKSYQESGGTTLSTNWEEVKKSRVEVKPPEGGEWKKWGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IWC9</accession>
    <name>A0A2H3IWC9_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Gfd2/YDR514C-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_135607</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
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        <property type="entry name" value="Gfd2/YDR514C-like"/>
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        <property type="entry name" value="RNaseH-like_sf"/>
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        <property type="entry name" value="GOOD FOR FULL DBP5 ACTIVITY PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="159"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="374"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21762"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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        </source>
    </evidence>
    <sequence length="428" mass="48453" checksum="8DD951682CC6503B" modified="2018-01-31" version="1">MYNRRLVDVRDGSLYDLHSVYAGYVLRVTASYALWHEQPWGNYLKSFSEFLSFGWPVVTVTSSATGKSHVATWDERIVAFREMITRRYGYSFPRINDSVAVPVPVVEVGQQTERKIFNIENYNQLHATLARVQLAAMKTRVENGVPEAIRELWDAKDKTFLSIDFEWSEQDPSLILEWGFAYMRCSFLNLKGVWPPVPENNYGEGHIVVSEYADEVRNKYRPNYPWTYAFGESSVSPRHNLPTIIQAIINSLASPDSDTVVNDLVLVAHGVYGDLQKLEEMNIDIPSNVLVLDIATYEKQLYRSGQRGIKPMKLADGRARRDHDMLKLETLLGTLGVDVRCQLHNAGNDAYMGLLALQLLFDPDNTVVPQQRRKQAKQKAVKSAGRGQSSHGGAVQCAPSGRRSPEYLTHRTGVLIAEPAIDIWEYDL</sequence>
</entry>
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    <accession>A0A2H3IXP9</accession>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
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                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
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            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="MDR7"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ER"/>
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    </dbReference>
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        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C1773.06C"/>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="17"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH34501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="346" mass="37088" checksum="38DFA7254319098A" modified="2018-01-31" version="1">MPIPTTTREYRLPKVDGFHNLTLQEAPLRAPKSSEVLVKIHAVSLQYRDLIVAKGQYPLGQKENPVPGSDMAGEVIAVGDDVKGWKVGDRVCANFALDHIFGDVTDEIKATGLGAPVDGVLTEYRLFPAHSLVHIPSHLSYEEASTLPCAALTAYNALMGLRPLKGGDYVLVQGTGGVSIFGLQFAVASGATVIATSSSDKKLEIAKKLGAKHLINYKKTPDWEKEVLKITNGRGVDHVIEVGGSGTIMKSLASVRYAGIVSVIGFVAGGGDVSSLPVAVLGKSSIVRGILIGSRAQFEDMNRLIVAQNLKPVIDRVFSFEDVRAAYEYQESQQHVGKVVIRVSKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IY66</accession>
    <name>A0A2H3IY66_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Homeobox-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WOLCODRAFT_139647</name>
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    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Barry K."/>
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                <person name="Otillar R."/>
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                <person name="Ferreira P."/>
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                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
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                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
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                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
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                <person name="Larrondo L.F."/>
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                <person name="Ling A."/>
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                <person name="Nagy L.G."/>
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                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
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                <person name="Stenlid J."/>
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                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 2">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:sequence-specific double-stranded DNA binding"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="HD"/>
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        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
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        <property type="entry name" value="Paired_homeobox_Bicoid"/>
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        <property type="entry name" value="HOMEOBOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46255">
        <property type="entry name" value="SHORT STATURE HOMEOBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
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                <person name="Ohm R.A."/>
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                <person name="Ruiz-Duenas F.J."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">MD-104</strain>
        </source>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
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                <person name="Benoit I."/>
                <person name="Boyd A."/>
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                <person name="Coutinho P.M."/>
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                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
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                <person name="Hesse C."/>
                <person name="Hori C."/>
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                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
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                <person name="Kuo A."/>
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                <person name="Lindquist E."/>
                <person name="Ling A."/>
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                <person name="Lundell T."/>
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                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
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                <person name="Sabat G."/>
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            <dbReference type="DOI" id="10.1126/science.1221748"/>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Ferreira P."/>
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                <person name="Glotzer D."/>
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                <person name="Heitman J."/>
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                <person name="Murat C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5 6">MD-104</strain>
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        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012959">
        <property type="entry name" value="CPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040059">
        <property type="entry name" value="PUM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13389">
        <property type="entry name" value="PUMILIO HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13389:SF0">
        <property type="entry name" value="PUMILIO HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08144">
        <property type="entry name" value="CPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="PUM-HD" evidence="4">
        <location>
            <begin position="112"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="42"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="82"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PCH37111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="651" mass="71932" checksum="F8A15CBE7A063AF3" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J5L2</accession>
    <name>A0A2H3J5L2_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein-S-isoprenylcysteine O-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WOLCODRAFT_158247</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + S-adenosyl-L-methionine = [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:21672"/>
            <dbReference type="Rhea" id="RHEA-COMP:12125"/>
            <dbReference type="Rhea" id="RHEA-COMP:12126"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90510"/>
            <dbReference type="ChEBI" id="CHEBI:90511"/>
            <dbReference type="EC" id="2.1.1.100"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.100" evidence="5"/>
    <dbReference type="EMBL" id="KB467931">
        <property type="protein sequence ID" value="PCH37532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J5L2"/>
    <dbReference type="STRING" id="742152.A0A2H3J5L2"/>
    <dbReference type="OMA" id="WAERTRY"/>
    <dbReference type="OrthoDB" id="422086at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004671">
        <property type="term" value="F:protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007269">
        <property type="entry name" value="ICMT_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12714">
        <property type="entry name" value="PROTEIN-S ISOPRENYLCYSTEINE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12714:SF9">
        <property type="entry name" value="PROTEIN-S-ISOPRENYLCYSTEINE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04140">
        <property type="entry name" value="ICMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PCH37532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="237" mass="26674" checksum="F0ED99AA1BBE67F2" modified="2018-01-31" version="1">MASLRITLLLAASSSTHLVFTDPSDSVKAEEKQRFRGGDLLTRIQYLMSLFLKSILWELTLSESAVLFALHYPCPTSAQLLYLLMREGSIFMPHLGITPLFIAGSLMQIFGFLIRRACFRTLGRHFTFALAMRDDHKLITNGPYAIVHHPSYTGGMMVFVGMLFVLSGRNSWWAECGPSDILASKVLMTVWSATTPAAASMLVLRTGKEDAVLREEFGSQWDKWAERTRYRLVPGLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J6J3</accession>
    <name>A0A2H3J6J3_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Phospholipase A-2-activating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WOLCODRAFT_22920</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH37882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J6J3"/>
    <dbReference type="STRING" id="742152.A0A2H3J6J3"/>
    <dbReference type="OMA" id="DKCIYYW"/>
    <dbReference type="OrthoDB" id="10265988at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010992">
        <property type="term" value="P:ubiquitin recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000236">
        <property type="entry name" value="Polyubiquitin binding protein (Doa1/Ufd3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.870">
        <property type="entry name" value="PFU (PLAA family ubiquitin binding), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015155">
        <property type="entry name" value="PFU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038122">
        <property type="entry name" value="PFU_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013535">
        <property type="entry name" value="PUL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TAF13 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH38062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="742152.A0A2H3J720"/>
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    </dbReference>
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        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07978">
        <property type="entry name" value="HFD_TAF13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003195">
        <property type="entry name" value="TFIID_TAF13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11380:SF5">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11380">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID/SUPT3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02269">
        <property type="entry name" value="TFIID-18kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Histone-fold"/>
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    </dbReference>
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    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="62"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="62"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PCH38062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="236" mass="25965" checksum="1423883ACB09C3D7" modified="2018-01-31" version="1">MSHYTQPTHPGTTYPYTPYTYPGQTPSPYATTPYQTPYATAVTGYGATWHYPYNYYQYQQPQPAQSASNHPRPTVSTTAAAPATSNAATPVAPALPRSTPAPTTYTFAQSYTPANVGGVSSGRGGRKQSTFKGLFAKELRNLMYGFGDDRNPANDTVNVMEEILIEYIVDVCQTALAPGKNKTRLSIEDLRRALSRPADAKKLARMEELLFMQEDIKRARAQFEESDMTRAGSLQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J735</accession>
    <name>A0A2H3J735_WOLCO</name>
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        <submittedName>
            <fullName evidence="4">60s ribosomal protein l34-b</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WOLCODRAFT_128392</name>
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    <organism evidence="4 5">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL34 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467931">
        <property type="protein sequence ID" value="PCH37455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="742152.A0A2H3J735"/>
    <dbReference type="OMA" id="RCHKCVR"/>
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    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:structural constituent of ribosome"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.370.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008195">
        <property type="entry name" value="Ribosomal_eL34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038562">
        <property type="entry name" value="Ribosomal_eL34_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018065">
        <property type="entry name" value="Ribosomal_eL34_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10759">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01199">
        <property type="entry name" value="Ribosomal_L34e"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RIBOSOMALL34"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01145">
        <property type="entry name" value="RIBOSOMAL_L34E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PCH37455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="115" mass="12910" checksum="844CD047582657FC" modified="2018-01-31" version="1">MAQRVTLRKRNPYNTTSNRRRVVKTPGGKLLYHHIKKPVTAPKCGDCGIALPGIIALRPRKYATISKTKKTVHRAYGGSRCGDCVKQRILRAFLIEEAKIVKKVIKSQEKTGGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J7E2</accession>
    <name>A0A2H3J7E2_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_155301</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467832">
        <property type="protein sequence ID" value="PCH34649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J7E2"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH34649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="84" mass="9112" checksum="9570B9B0FFC3139D" modified="2018-01-31" version="1">MGRLGRWQAPAHSTRHGFCRRMKSIGARAVSALKATRDGLAYATDAWSATGEDDHPGKRPTRVGKAIASVDAVRANGEHRRVTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J8F2</accession>
    <name>A0A2H3J8F2_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_65429</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH38500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J8F2"/>
    <dbReference type="STRING" id="742152.A0A2H3J8F2"/>
    <dbReference type="OrthoDB" id="2740399at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH38500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="66" mass="7222" checksum="3A9E42005EB6CBC4" modified="2018-01-31" version="1">MCGFLSCHLDIHLGKPPGLDPKRAQAFNVATVACHFELLQKVLDKLGIPWSNVYNMDEKGVQRGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J8F9</accession>
    <name>A0A2H3J8F9_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WOLCODRAFT_130924</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH38486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J8F9"/>
    <dbReference type="STRING" id="742152.A0A2H3J8F9"/>
    <dbReference type="OMA" id="PEIMIWR"/>
    <dbReference type="OrthoDB" id="3066029at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF64">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11760)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="183"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="252"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="287"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="332"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="363"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="409"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="432"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="34"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PCH38486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="466" mass="50137" checksum="A090344B377A9804" modified="2018-01-31" version="1">MSSEESPLLRAAEPIRDEEDRVYDRFTSRQKRVIVAVVSWTGLIPLFVSSSFVPAIPQVAHDLGTTGSVINLSVSLSMVTASVSSLIWAKYSSYYGRRPIYLASLPCLCAGALGVALSRSVLSLILFQTLQAFGYASGISVGAGVVGDICRVEERGSAIGIFFGASLLGAALAPLTGGTVTHYISWRAMPCILCLAGLVALLLTALYLPETSHPGKRGVDKLLSEDSSDAQRWRWVWLNPFSSLKLLQSPNLMLMTLMTSCVLLTDFVLLIPLSYTIGARYHIKNEALVGAFFIAAGVGNITGAPLAGRISDHVVVKWRLRRHGEWVPEDRLRATLLPAATLVPLSVLLSGLTTQFIEGKPGIVLNVICLFMNGIGVDMTLSPVNAYLVDAMHTRSAEIIAAQKGVRNLLVAMATAGILPLINHIGVASTNAISAAIAWIGFFLLWLTVHYGSRMRAWSSQSDIDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J8L1</accession>
    <name>A0A2H3J8L1_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WOLCODRAFT_129549</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the OSBP family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH33004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J8L1"/>
    <dbReference type="STRING" id="742152.A0A2H3J8L1"/>
    <dbReference type="OMA" id="LPEMKGW"/>
    <dbReference type="OrthoDB" id="1854502at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097038">
        <property type="term" value="C:perinuclear endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030011">
        <property type="term" value="P:maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13292">
        <property type="entry name" value="PH_Osh1p_Osh2p_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.120:FF:000017">
        <property type="entry name" value="Oxysterol-binding protein homolog C2F12.05c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018494">
        <property type="entry name" value="Oxysterol-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF205">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01013">
        <property type="entry name" value="OSBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="5" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="87"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="190"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="10">
        <location>
            <begin position="260"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="364"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="411"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="612"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="549"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="432"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="617"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PCH33004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="1160" mass="128586" checksum="E8E577F4FED6DCB9" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J9D8</accession>
    <name>A0A2H3J9D8_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carbohydrate-binding module family 19 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_147366</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH33264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J9D8"/>
    <dbReference type="STRING" id="742152.A0A2H3J9D8"/>
    <dbReference type="OMA" id="ENACVNS"/>
    <dbReference type="OrthoDB" id="2336871at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053216">
        <property type="entry name" value="Appressorial_penetr-assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34587:SF2">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34587">
        <property type="entry name" value="VWFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013561239" description="Carbohydrate-binding module family 19 domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH33264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="399" mass="40106" checksum="A6AF4E5C05CC7F0D" modified="2018-01-31" version="1">MVYAAVLATVALFASSTLARPSYLPRDSSFLQLNGEEAIALNAQFKTLTATSSCTDGTSACVNGEFAQCVSGNFVLTSCGSGLTCAALPLVNSAGTSITCATQQDVDERIAASGATSASDSSSSAVASASSAVASASSTKAATCTVTVPAAKATASSATASAASSTASAVSTSTNTSDAQSSLTLLSSLVNTGFQQVGTEEFSPEAGEIASATSANNFINFCATVNLPLTNGTQVQGGSCNAAPMGVIASTNNMPSAKFVHPPNLGTVPANTTFSVVLAVERLQTGHFVNPDTNFFAAPQTVNATTGDILGHSHVVIERLAALNQTTPTNPGTFAFFKGLNDVAVNGTLTAEVTNGLPSGVYRMASINAAANHQPVLVAVAQHGTLDDMLHRRMNGLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J9I9</accession>
    <name>A0A2H3J9I9_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TauD-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WOLCODRAFT_159981</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH33324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J9I9"/>
    <dbReference type="STRING" id="742152.A0A2H3J9I9"/>
    <dbReference type="OMA" id="IYRHQWQ"/>
    <dbReference type="OrthoDB" id="10257314at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000003">
        <property type="entry name" value="Alpha-ketoglutarate-dependent taurine dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051323">
        <property type="entry name" value="AtsK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468:SF28">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT TAURINE DIOXYGENASE (AFU_ORTHOLOGUE AFUA_8G02210)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="7">
        <location>
            <begin position="86"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PCH33324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="373" mass="42155" checksum="33AF21D78D045E69" modified="2018-01-31" version="1">MSTTQTIIQSVTESLPSSLTLRPAPAENNGQQNQDNSEYRYAHLLPVFPKDEHYPPLTPFEHVDPGARALTHPNPRAFLDNATSIVQLTPHLGEEVRGVSLAALDSDGRDQLALEVARRGLVVFRDQQDFIDRGPDFYLEWGRHFGRLHIHPTSGHPESYPELHLVYRDANTTYNFEREERITSTTWHSDVSYEFQPPGLTTFFLLAAPDTGGDTAFTSQIAALKRLSPQFVAFLRTLKAVHSGVEQANYSRAGNRGGVVRREPVENVHPVIRRHPVTGEEAIYVNRQFTRRIVGLKREESDAILNLLYDHIDRSVDIQARVKWQPYTVVLWDNRITAHSAIVDYVASGQRRHGARITPQAERPIPALEGLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J9T0</accession>
    <name>A0A2H3J9T0_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_167762</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467954">
        <property type="protein sequence ID" value="PCH39022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J9T0"/>
    <dbReference type="STRING" id="742152.A0A2H3J9T0"/>
    <dbReference type="OrthoDB" id="527344at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042781">
        <property type="term" value="F:3'-tRNA processing endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46018">
        <property type="entry name" value="ZINC PHOSPHODIESTERASE ELAC PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46018:SF2">
        <property type="entry name" value="ZINC PHOSPHODIESTERASE ELAC PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH39022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="460" mass="49091" checksum="D09C65EB7356F185" modified="2018-01-31" version="1">MPEEVESTSTSVASPQAAHPPLSPSMPQSTPCLIPCTPPPSIPYPVSPTDHVAGLLTLLRSVLGAAPSRASGGAAEPPRIEIFGPRGLRRLLRTQIVLTHTRSAKRYAVHELLAPGEAPSAPAEEEIPENEAPGLDIACNAAGFWRAIVRAHAFGNPRSAGVVVVDAGPIEHRDPCIGYVIREEPRDLSPATPVPRKIVILGDTSNPYALVPLIHPTLPTDNASGGSSDAPIEIPDEAPDAPAPTPTSAPTPVSLLVHEATDAFIPAHIDPEERTGRNRSPQIVHEKTIERGHSTPAMAGAFARTIGAERLVLNHIGSRFPAPAMPARSSMDRFRTQCMLEIQAQAQLTWMPANGAQVQAAYDYMRVVIPPNPSLSLETEDATGDVAHPDSMGGPGGENTGDAGKKRERLGEPADKVHRPRRRDRSSEDGGSWARLFKEMLKLMLADLGMYGGKNIDMNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JA26</accession>
    <name>A0A2H3JA26_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">WOLCODRAFT_21329</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467954">
        <property type="protein sequence ID" value="PCH39056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JA26"/>
    <dbReference type="STRING" id="742152.A0A2H3JA26"/>
    <dbReference type="OrthoDB" id="3267359at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH39056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="303" mass="32950" checksum="A1B6D975208549B9" modified="2018-01-31" version="1">MKHELQMLNLRTGIECAIIGTRGDLDTYNSPYYYATSKRVADFFEATFKTNLADIGLRMEAYLISGIQGIVSNHVQELLDLKEQMAALILHKLNEAAKTKVPRMYYNNFKTSITAKYGVVCEGWLLSKFCCPSDVGSCTELMVLNHAFKSGSARFHAMGTEEFKKWQDKQFQAAIGGVENREDSGSDMSNLSNTILTPPSTLAPATLAPSTLAPQSSAPTMPLPTFVPPPTFVSPASALETPLYTLAPLPLTSNTLHLQQTGTLITITMDHNSEQQCSTPLTTNFINAVTAADGSGVLSNAKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JA66</accession>
    <name>A0A2H3JA66_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WOLCODRAFT_93686</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467831">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="742152.A0A2H3JA66"/>
    <dbReference type="OMA" id="SHERRAD"/>
    <dbReference type="OrthoDB" id="10248252at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030621">
        <property type="term" value="F:U4 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:U6 snRNA binding"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19846:SF0">
        <property type="entry name" value="PRE-MRNA PROCESSING FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19846">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="63"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="325"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PCH33544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="402" mass="43256" checksum="F6A02F21E3E4C8DA" modified="2018-01-31" version="1" fragment="single">MAQSAHGTVAIASAVANGEEGDEPGPYNRDGTLAVWAHDRYHILPGHIVSASSPFQEFRYSTVVDVAFNPAFPERLISSGTDRTIAIWDCDSFEYGVDEPRGHIVHTACPMGILSFKPAEPLLAMAGRDGCVYLHSDKPNMPAVTDILRLAPRSGHEVADIAWGVNGSSHALFASSAPLAYGVYDGVHKVFDFEKSKTLCTFDTQAEGERIALDQAGERLAVAVRSSATAHALRMYDARRLARASVQSIDLQPFDGEVNAVAFGPGGIYIAIARSDNSAHVYDSRFLGREPMHVCKHREGNVISKDTSGVTEAVWTEGTSRGMGLVTGGVDGCIRLWDVRQAPSDASDDNVLVQCDDDIGSFVLGDHPDTPLIVARILAKSPFSTATLKQDMMLDIARDLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JAF4</accession>
    <name>A0A2H3JAF4_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_158755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467965">
        <property type="protein sequence ID" value="PCH39210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JAF4"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH39210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="61" mass="6698" checksum="7086689E1884A011" modified="2018-01-31" version="1">MSQKSRSSAIPAWLAAWHLTHGHASGGRLPGDCRHPRGAWQVAARDRQTSSAVGREPLRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JB24</accession>
    <name>A0A2H3JB24_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_157714</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467909">
        <property type="protein sequence ID" value="PCH37013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JB24"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH37013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="372" mass="39166" checksum="900DC1C298DEBA2B" modified="2018-01-31" version="1">MPPLSATSKGPHLSSTRRERPPAGHKGDPCPTRNPVAIATATKPTQGQGLGVTAATASPVPAKRHPARISARQAGPGKRVAPNAVTASHIQPPGRTAVPPALPNVPPPPPTASTALTQARRAVRQTPATGSRARPKGTRYPGEVTPSHVSTGISHSSTAEGQGRQALEASRIGNAASPQVKATATSTHADPFGEATPRVHGPRVQRGPLLKSAGSPLKYGARQTLKVAAQHLHQRARHLQPRKDLSNYQGPERNAYAQRDKGPTSPNPPSPLRSPPDSRAANPRQGAHLRDPETKEQTKASRKDENQQGRSDRESGSPLTGTRSTDDKPEQQGPLAGATPLTSPPQASPSVKTKRLPPLEQGRMAKKKEEEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JBE5</accession>
    <name>A0A2H3JBE5_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WOLCODRAFT_29436</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467976">
        <property type="protein sequence ID" value="PCH39231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JBE5"/>
    <dbReference type="STRING" id="742152.A0A2H3JBE5"/>
    <dbReference type="OMA" id="CCEICTH"/>
    <dbReference type="OrthoDB" id="3219336at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16449">
        <property type="entry name" value="RING-HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23327">
        <property type="entry name" value="RING FINGER PROTEIN 127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23327:SF51">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR OF YEAST FORM ADHERENCE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="149"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="51"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PCH39231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="293" mass="32236" checksum="12724A3893D6A3C7" modified="2018-01-31" version="1">MPAQRTTRHASRQPSHIKALSSSPTPGPDPEVIVISSDEDTPLSRKSSVQPRHRRTQAKGKGRLPPPPHDIIEISSDEEGGPPRRMPTPSRSPVASRRRQPQNTRAEPRRPSSSTHRRATSELSATEPSVCILAQSQVPISMLEDRIGCEICLLPMWTPYALSCGHTFCQSCLQEWFSTILAHHMHATPGYNHVRIAELNAQLREPELHIQMRHGIIALLSSIEAETPSPTYSCPFCRDTVTSRPSEVFALKNVVHAIATANGESPPKKPLPPNAAPSGVGGLWDGFFPRTTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JBE7</accession>
    <name>A0A2H3JBE7_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_159108</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468009">
        <property type="protein sequence ID" value="PCH39516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JBE7"/>
    <dbReference type="STRING" id="742152.A0A2H3JBE7"/>
    <dbReference type="OrthoDB" id="5569250at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="397"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH39516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="736" mass="82825" checksum="769A809EC9D0B3C4" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JBM9</accession>
    <name>A0A2H3JBM9_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WOLCODRAFT_134125</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB467865">
        <property type="protein sequence ID" value="PCH36139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JBM9"/>
    <dbReference type="STRING" id="742152.A0A2H3JBM9"/>
    <dbReference type="OMA" id="VEFSHIH"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF564">
        <property type="entry name" value="STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="8"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PCH36139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="326" mass="36109" checksum="79665A71F855E319" modified="2018-01-31" version="1">MSNSKPLVLVTGVTGFLGSHIVKLLLEKGFHDNYEVVPIDDLAGGDCNVALQARDRVIVHQAAPLPNRETSTEDILNAPIEGNLNILRQGDKAGITKFVFASSWNTLGAARGARPTRVLTDQDWGTLTREDAIAAGDPWLTYRAEKLLSERAVWDYVDQHQHIDVTTVNPSLLYGPFAPGYRIPEPKLGALGSNAFMYPLLIPSAKPLEWCSLGVDVRDVAQAMINALSAPSNVGRKRMLLTAEWFSWKDAVEYIAAERPALKDRLSVAAWDAEPVDFTPFDPSRAKEVLKVEFRPWQATVLDTVDALVTWENDWKSKGLKFDPTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JBT3</accession>
    <name>A0A2H3JBT3_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">tRNA-dihydrouridine synthase</fullName>
            <ecNumber evidence="16">1.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">WOLCODRAFT_79474</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>5,6-dihydrouridine(16) in tRNA + NAD(+) = uridine(16) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53380"/>
            <dbReference type="Rhea" id="RHEA-COMP:13543"/>
            <dbReference type="Rhea" id="RHEA-COMP:13544"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="13">
            <dbReference type="Rhea" id="RHEA:53382"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>5,6-dihydrouridine(16) in tRNA + NADP(+) = uridine(16) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53376"/>
            <dbReference type="Rhea" id="RHEA-COMP:13543"/>
            <dbReference type="Rhea" id="RHEA-COMP:13544"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="11">
            <dbReference type="Rhea" id="RHEA:53378"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>5,6-dihydrouridine(17) in tRNA + NAD(+) = uridine(17) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53372"/>
            <dbReference type="Rhea" id="RHEA-COMP:13541"/>
            <dbReference type="Rhea" id="RHEA-COMP:13542"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="10">
            <dbReference type="Rhea" id="RHEA:53374"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>5,6-dihydrouridine(17) in tRNA + NADP(+) = uridine(17) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53368"/>
            <dbReference type="Rhea" id="RHEA-COMP:13541"/>
            <dbReference type="Rhea" id="RHEA-COMP:13542"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="15">
            <dbReference type="Rhea" id="RHEA:53370"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 5,6-dihydrouridine in mRNA + NAD(+) = a uridine in mRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69851"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="12">
            <dbReference type="Rhea" id="RHEA:69853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 5,6-dihydrouridine in mRNA + NADP(+) = a uridine in mRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69855"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="14">
            <dbReference type="Rhea" id="RHEA:69857"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 16 18">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the Dus family. Dus1 subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the dus family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.-" evidence="16"/>
    <dbReference type="EMBL" id="KB467843">
        <property type="protein sequence ID" value="PCH35128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JBT3"/>
    <dbReference type="STRING" id="742152.A0A2H3JBT3"/>
    <dbReference type="OMA" id="NPCLFAN"/>
    <dbReference type="OrthoDB" id="272303at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106414">
        <property type="term" value="F:mRNA dihydrouridine synthase activity"/>
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        <property type="project" value="RHEA"/>
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        <property type="term" value="F:tRNA-dihydrouridine16 synthase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Aldolase_TIM"/>
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        <property type="entry name" value="DUS_fam"/>
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    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082:SF5">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(16_17) SYNTHASE [NAD(P)(+)]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
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    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006621">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 16" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 16 18" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 16" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="DUS-like FMN-binding" evidence="19">
        <location>
            <begin position="12"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="17">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="14"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00038313"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047287"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047652"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048342"/>
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            <dbReference type="ARBA" id="ARBA00048934"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00049467"/>
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    </evidence>
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        <source>
            <dbReference type="PIRNR" id="PIRNR006621"/>
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    </evidence>
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        <source>
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        <source>
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    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH35128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="292" mass="32467" checksum="F01511646FF184DF" modified="2018-01-31" version="1">MASVLDHLSLIAAPMVKQSDLPFRLLVRRYNASLVYTQMLLPHKLLSDQDYLEFHLRGLGEPCNDRPVVVQLCGNDADIVVQAGRKVQGHCDAIVDLNLGCPQEAARDAHIGAYLLGQKDWPLVEDIVSAMSHSLTVPASAKIRLCQPAPATFEFAQRLEHAGASWITLHARHVSARRRRQGLADLEQVKRLKSHLSIPVVSNGNVRTWEDVEANRAFTGADGIMVGESLLENPCLFANAVPDPVGISLEYLDLCRQHPGTATIQTVQTHIRHFVDHRWFVPIRFYMLISGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JC34</accession>
    <name>A0A2H3JC34_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6699 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_136510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468053">
        <property type="protein sequence ID" value="PCH39822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="DUF6699"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20415">
        <property type="entry name" value="DUF6699"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6699" evidence="2">
        <location>
            <begin position="181"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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            <dbReference type="Pfam" id="PF20415"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH39822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="335" mass="37211" checksum="8DB196AA9FCE71CA" modified="2018-01-31" version="1">MFKKLLKSLDSTPPTPKIGRLELPEVEDGGVFYISTDGPSVIAQQYSSDSEASSPRSPIAPWRRPSTPQPESFKPRRKTAVVQASSLLSPRYASSSAQLDDRKPVSIIPSPKAEARDSCSRSTTPQPGSSRSAGKSAPSSYSSSSAKPALKGILKPAPPLQPMTLHWQLLPYDPAHSKKLIYFDIARDVSFIRDHTRLPPTRLAPDDLAKAAAEIPLTLMKLRCAQIPHWDIVAQPTGPGGVRCVDVFRAIHDMFRRPLSETEKEFYILPERRARCEQAFRRRCRESPGCDADGMRRVDLLEGRTIFMGLRRPVESDGKPDEYWVLELGLPKGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JC94</accession>
    <name>A0A2H3JC94_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Actin-like protein ARP6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Actin-like protein arp6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WOLCODRAFT_131076</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Involved in chromosome stability.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the SWR1 chromatin remodeling complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin family. ARP6 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB468053">
        <property type="protein sequence ID" value="PCH39816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JC94"/>
    <dbReference type="STRING" id="742152.A0A2H3JC94"/>
    <dbReference type="OMA" id="FFEEYEC"/>
    <dbReference type="OrthoDB" id="6220758at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd10210">
        <property type="entry name" value="ASKHA_NBD_Arp6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000014">
        <property type="entry name" value="Putative actin-related protein 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.36.70">
        <property type="entry name" value="Actin, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="413"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="413"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00063309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00073820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PCH39816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="469" mass="52820" checksum="95E864676DA36C45" modified="2018-01-31" version="1">MTLRKSATVVADNGASTIKAGVMGVHDANSRVITNAIVRSKGDKTTYIGHELGNCRDYSSLHYRRPFEKGYIVDWDAEKAIWDGMFSNDCLEVDTSESNLLITEPYFNLPNIQEVYDQFVFEEYEFQSYYRCTPASLLPYSEIFNSVNSTSPECLLVIDSGFSFTHIVPILNGAVVWKAVKRLDVGGKLLTNQLKELASFRQWNMMDETHIINDIKESCCYVATDLKKDMETTRTDPKRNPIVQEYILPDFSINRSGRIRQAGEALPEAAQVMYMNNERFTVPEIIFRPDDIGLEQLGVASAVASSVALLPEDLQGMFWAHIGLIGGNAKFPGFCERLHNELRSLAPNDCEVSIYLSNEPLIISSPILEAYRSAVAFARTPEFAQRVVTREEYLEMGSNACRRKFADWKPIDKDATKGRDQTRARGTTRTREGTTRTREELDETDSPPPPKKGAGGKTRTRTSISRRQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JCE7</accession>
    <name>A0A2H3JCE7_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Thioredoxin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WOLCODRAFT_140401</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PheA/TfdB FAD monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467876">
        <property type="protein sequence ID" value="PCH36409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JCE7"/>
    <dbReference type="STRING" id="742152.A0A2H3JCE7"/>
    <dbReference type="OMA" id="NIGWKLR"/>
    <dbReference type="OrthoDB" id="1716816at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02979">
        <property type="entry name" value="PHOX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012941">
        <property type="entry name" value="Phe_hydrox_C_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038220">
        <property type="entry name" value="PHOX_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF20">
        <property type="entry name" value="2-MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G13660)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07976">
        <property type="entry name" value="Phe_hydrox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="1"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Phenol hydroxylase-like C-terminal dimerisation" evidence="6">
        <location>
            <begin position="221"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PCH36409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="401" mass="44456" checksum="31FC86E751B37489" modified="2018-01-31" version="1">MEGEQTDYIWGVLDFVPDTDLPDIRIFCAVHSHNGSCMVIPREGDTVRLYVQLSDADVQDAATGRVDKSKFSPERLLDVARRSLSPFTIAAPRGVEWWTLYIIGQRVASKYSVQERVFIAGDACHTHSPKAGQGMNASINDSHDLAWKLTHVIRGWAGLSLLKTYEFERRKYAQDLIAFDKRWSALFSGKPRTDEDADGVTHEEFLEALKTSDQFMSGIGVYYAPSVLTRMTHQASAHGLVIGQRLHPHIFVRAADARPVDIHDMLPADGRFGVAVFAGDADTHLATLAHSLDTLLRRHADQRGGVAAVFNVFTVLARSKDDVNYTDVPELLRPHWSKVLLDDTDMFGRSGGGGYDAYGIDRARGAVVIVRPDGFVGTVAPLEDLSEIDEYFSSFMVETQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JCH2</accession>
    <name>A0A2H3JCH2_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_93923</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH33657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JCH2"/>
    <dbReference type="STRING" id="742152.A0A2H3JCH2"/>
    <dbReference type="OMA" id="DYAAMTW"/>
    <dbReference type="OrthoDB" id="10017101at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="39"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH33657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="275" mass="30098" checksum="408713C40FFC71E9" modified="2018-01-31" version="1">MAAPAKDPYINGHHESVLRSHSWRTAENSAAYLLSSLRPDMHILDVGCGPGTITIGLAARVPQGQVIGLENTAATQEQATASAAARGLTNVRFIVGDALALDFPDNTFDIVHAHQLIQHVPDPVKALSEMRRVTKPGGVVAVRSVDFSTFTWFPELGIQQDLLDWRGTHIRVGRALGGEPEAGRRLVAWARQAGFERSHITASASAWCYSTAEERAWWAALWADRILLSSFAKNVIDGGFGTQDDLDRMSCAWRKWGASEDGWFAVMHGEILCRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JCN1</accession>
    <name>A0A2H3JCN1_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_142851</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468053">
        <property type="protein sequence ID" value="PCH39956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JCN1"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH39956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="134" mass="14631" checksum="77D7D30057E80708" modified="2018-01-31" version="1">MLVARLSTMCADGLVLLLSIIKTRGILRLHKSLHSDKPISLSEAVFRESAFSFLILFAINAICTMLCLLGLGSLLWPSLQIVELLSSWVALFLLDLREMSDSTIDSAASQSDIIFANRDISCGEGVQSSQDLND</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JEG8</accession>
    <name>A0A2H3JEG8_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_29743</name>
        <name evidence="3" type="ORF">WOLCODRAFT_29785</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467842">
        <property type="protein sequence ID" value="PCH34944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KB468085">
        <property type="protein sequence ID" value="PCH40642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JEG8"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH34944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH40642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="77" mass="8103" checksum="BE404548F5DBEDC8" modified="2018-01-31" version="1">MGVGGGASTSTTAVAQPVPKPQEVIDLSNDLASDSDKTAAGAASQLEEFMHADSPDLTELFSDDPWSTRKIDFGYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JEQ8</accession>
    <name>A0A2H3JEQ8_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Bicarbonate transporter-like transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WOLCODRAFT_136829</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the anion exchanger (TC 2.A.31) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468053">
        <property type="protein sequence ID" value="PCH40371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JEQ8"/>
    <dbReference type="STRING" id="742152.A0A2H3JEQ8"/>
    <dbReference type="OMA" id="RRAPFYW"/>
    <dbReference type="OrthoDB" id="1735926at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080139">
        <property type="term" value="F:borate efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005452">
        <property type="term" value="F:solute:inorganic anion antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050801">
        <property type="term" value="P:monoatomic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.570:FF:000003">
        <property type="entry name" value="Anion exchange family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.570">
        <property type="entry name" value="Helical hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011531">
        <property type="entry name" value="HCO3_transpt-like_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003020">
        <property type="entry name" value="HCO3_transpt_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453">
        <property type="entry name" value="ANION EXCHANGE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453:SF82">
        <property type="entry name" value="BORON TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00955">
        <property type="entry name" value="HCO3_cotransp"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH41256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="557" mass="62993" checksum="35366B73F1F01FE9" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JGG4</accession>
    <name>A0A2H3JGG4_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Golgi apparatus membrane protein TVP38</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Golgi apparatus membrane protein tvp38</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WOLCODRAFT_137281</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Golgi membrane protein involved in vesicular trafficking and spindle migration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TVP38/TMEM64 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH41266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JGG4"/>
    <dbReference type="STRING" id="742152.A0A2H3JGG4"/>
    <dbReference type="OMA" id="KWQALET"/>
    <dbReference type="OrthoDB" id="166803at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000022">
        <property type="term" value="P:mitotic spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051076">
        <property type="entry name" value="Golgi_membrane_TVP38/TMEM64"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="VTT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47549:SF1">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47549">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP38-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="VTT_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="74"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="VTT" evidence="11">
        <location>
            <begin position="94"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF09335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PCH41266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="297" mass="32755" checksum="91CAFBE178A99FF7" modified="2018-01-31" version="1">MTESNRLRWMLSLLRYYAVSAFRRYQKLHLHGKLFIWGTACIYLTLASIFIFVGPARIGQTLYDLAQKISHRSYGWVMLGGAIVVISFPPCIGHTTLITLCGYAYGMKGFPIAAVASLLGSALAFVVLRFLFRGRLRRWSASNEKWQALETVVAAKGLPLIALIRASPFPPWVYSNALFASIEAVSLWQFFLATFVIFPKIALLVFVGSRLASLSDGEQRSHMDTSTKILNAAVSIGGLLLGLTASFIVYRAMQSEIRRLQGLSPEVDELAVEALEEAEEGAPLLGTYAESAPRPTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JGN5</accession>
    <name>A0A2H3JGN5_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_143370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH41061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JGN5"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH41061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="158" mass="16760" checksum="456EBCFDA84B452F" modified="2018-01-31" version="1">MAFNLKNLPPVAEDSASSLSSGSVVIIPWDRPPEIFERPAGMAPDPVLEACLQPYRDYYGGRLRYGPNGEPIYVTQHPGHPDVDVGMDTSSGSAMSREDLPGQTSIATAAVEGQEVIEFEATDGSQGTEVYAAYDALGLASGDLVTEPMAVDVNDMPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JGP5</accession>
    <name>A0A2H3JGP5_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_162789</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH41071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JGP5"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH41071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="339" mass="37110" checksum="F17DD267CBEA5EF6" modified="2018-01-31" version="1">MDNGCSRASRGATFTETPEHKFNIAHLPSVDPTTTTHHPSTADPDHSFKMTFKFLSNRKIPRHLMIRRFKATFLGVVIRIHRVSTVRRDGRLVEHEHGKYQSPVVSDSASSLSSGPVMRVPWDRPPEIFERPAGMAPDPVLEACLQLYRDYYEGRLSYGPNGEPIFLEQVPDHPEVNISAHIPDGIMSEDTHGGRAELSPAAAYACTQARRLGLSQNIHMVQSGQRDGCHLDRTSVAATAAEGQEAVEWPTFEAANGAQDAGVYVAHSALEPEPRVVHANGFARVDVPFSSCPGLGMSAGWSERALKFPITLSLAIDAEFDQRLPSVNIARDSSANGLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JGQ7</accession>
    <name>A0A2H3JGQ7_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Piwi-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WOLCODRAFT_137178</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the argonaute family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH41081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JGQ7"/>
    <dbReference type="STRING" id="742152.A0A2H3JGQ7"/>
    <dbReference type="OMA" id="FARCTRP"/>
    <dbReference type="OrthoDB" id="10252740at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02846">
        <property type="entry name" value="PAZ_argonaute_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04657">
        <property type="entry name" value="Piwi_ago-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014811">
        <property type="entry name" value="ArgoL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032472">
        <property type="entry name" value="ArgoL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032473">
        <property type="entry name" value="Argonaute_Mid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032474">
        <property type="entry name" value="Argonaute_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045246">
        <property type="entry name" value="Piwi_ago-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08699">
        <property type="entry name" value="ArgoL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16488">
        <property type="entry name" value="ArgoL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16487">
        <property type="entry name" value="ArgoMid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16486">
        <property type="entry name" value="ArgoN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02170">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01163">
        <property type="entry name" value="DUF1785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00949">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50821">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAZ" evidence="3">
        <location>
            <begin position="306"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="Piwi" evidence="4">
        <location>
            <begin position="603"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="17"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="68"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU361178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PCH41081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="954" mass="104226" checksum="6E27DF78E2947EBE" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JHU3</accession>
    <name>A0A2H3JHU3_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_163355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH41752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JHU3"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH41752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="160" mass="18080" checksum="0E82F1A5917FEEBA" modified="2018-01-31" version="1">MPGGVCLSKISGTFYFLAELAMNVLVVVSRFTYNGFSHKQYAPDYVFTFLPYVSAILVSRFLFDLRQFQALRLAGEEEATCRVMTSDKHAMTTSKTVQFASEFITMIGAPLDHGRTEYEETAYNCEDLETDSSEEHPHLSYDEPQAEPVISEVRRSYSGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JIA3</accession>
    <name>A0A2H3JIA3_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_17392</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468124">
        <property type="protein sequence ID" value="PCH41930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JIA3"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH41930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="158" mass="17666" checksum="FB69C77483C1A44D" modified="2018-01-31" version="1">MPQNSAKGTDHVKFGQVPAKLSPTQQTQEQQAPLQWWADNNGPEGKMARNHPDAILIANLLVNERKSSIITEGDKIEQGAKLAAWSHGMVPHLIHVGINLWRHFCAEADTRIHGSANRIKAIVVQACPELQEPLDPIRSLFCKALHFPRVYFLLQLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JIA7</accession>
    <name>A0A2H3JIA7_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="13">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">WOLCODRAFT_101289</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 18">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 18">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Composed of two components (A and B), the A component is the catalytic subunit and the B component confers calcium sensitivity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PPP phosphatase family. PP-2B subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="13"/>
    <dbReference type="EMBL" id="KB468124">
        <property type="protein sequence ID" value="PCH41912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JIA7"/>
    <dbReference type="STRING" id="742152.A0A2H3JIA7"/>
    <dbReference type="OMA" id="DGKFFCV"/>
    <dbReference type="OrthoDB" id="5593063at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033192">
        <property type="term" value="F:calmodulin-dependent protein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097720">
        <property type="term" value="P:calcineurin-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07416">
        <property type="entry name" value="MPP_PP2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041751">
        <property type="entry name" value="MPP_PP2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043360">
        <property type="entry name" value="PP2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45673">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="6 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="15">
        <location>
            <begin position="103"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="527"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PCH41912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="546" mass="61883" checksum="3EB6F3D074DE75A6" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JIE1</accession>
    <name>A0A2H3JIE1_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Helicase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WOLCODRAFT_159221</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468020">
        <property type="protein sequence ID" value="PCH39633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JIE1"/>
    <dbReference type="STRING" id="742152.A0A2H3JIE1"/>
    <dbReference type="OrthoDB" id="3270319at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050496">
        <property type="entry name" value="SNF2_RAD54_helicase_repair"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629:SF7">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629">
        <property type="entry name" value="SNF2/RAD54 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="42"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="228"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="353"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="405"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="232"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="273"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="372"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PCH39633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="427" mass="48003" checksum="A574034742F85084" modified="2018-01-31" version="1">MNPSSKIDSLITLLKNHLVRDNAQPMKFNEDLQQLVIDEDYILDKRVTSLHPDKIIVYCVFLSNIPMITPFLQEHNIKYLWVVGQGMSIKQRSVNLEWFHKSRVNGSRMLLLSGIRMVGLNITNANILIIMDTLWSAQEDGQLIRQLWRHPQPKQVHIYWLIVAGTPNVFLNNISFKKGYMHKAFTEASSTLRELFTYVSGWDTFSSDDEIEFDEDSGEIIDSIDDTISPKAKGKSRAKSTSGKKKKMATTMKKLAMTTKKLATTTKKLATTTKKSMTATTRDTASSSKTRVDAAVTDTSMDNSNKELLRVPEKRMQKRMQKNKVVIISDDESDPLATSATALDQGTVLVKSTLEPSQAKNRPAPHPRYTLKAQSQSKESSPNAGLEDDIVDLLLDIVATLDMDEQSIHDSHQEDEDMGTPSESPLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JIL3</accession>
    <name>A0A2H3JIL3_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Homocysteine S-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WOLCODRAFT_81611</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD-104</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KB467865">
        <property type="protein sequence ID" value="PCH35837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JIL3"/>
    <dbReference type="STRING" id="742152.A0A2H3JIL3"/>
    <dbReference type="OMA" id="CSQPEVI"/>
    <dbReference type="OrthoDB" id="261426at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008898">
        <property type="term" value="F:S-adenosylmethionine-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033528">
        <property type="term" value="P:S-methylmethionine cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.330">
        <property type="entry name" value="Homocysteine-binding-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003726">
        <property type="entry name" value="HCY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036589">
        <property type="entry name" value="HCY_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051486">
        <property type="entry name" value="Hcy_S-methyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46015:SF1">
        <property type="entry name" value="HOMOCYSTEINE S-METHYLTRANSFERASE-LIKE ISOFORM 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46015">
        <property type="entry name" value="ZGC:172121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02574">
        <property type="entry name" value="S-methyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82282">
        <property type="entry name" value="Homocysteine S-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50970">
        <property type="entry name" value="HCY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 5 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Hcy-binding" evidence="6">
        <location>
            <begin position="1"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="344"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="345"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PCH35837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="362" mass="38633" checksum="38E958E34E5E5802" modified="2018-01-31" version="1">MSSDHVDILVLDGGLGTTLEDVFHHDISSPLWSAQPVEHNPELIIGAHTAFLDARADIILTATYQSSFETFERAGYSRADAERLMLKAVDLAAQARARYIHDKQGTAPRIALSLGPFGATLSPAQEFSGFYPPPYGPRGHSAGGGNTAAFPETDAGRREACAAEDALAAFHLARLRVFAGQRAAWAAAEYVAFETVPLAREVRAVRRAMGVLAGELRARGQAVRPWWVCTVWPDGAFPEEGVAMEGVVDALLGGAGPVPWGIGINCTSPERVGALLERMAECVGRRGADVPCLVVYPNRGDVYEPSTRTWRQAGPQEGWAGRLHADIARAAASGVWRQVIVGGCCKTGPAEIAALAMLVKQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JJ28</accession>
    <name>A0A2H3JJ28_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Carbon-nitrogen hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WOLCODRAFT_23552</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH38779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JJ28"/>
    <dbReference type="STRING" id="742152.A0A2H3JJ28"/>
    <dbReference type="OMA" id="MQSKPYA"/>
    <dbReference type="OrthoDB" id="10250282at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050152">
        <property type="term" value="F:omega-amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006528">
        <property type="term" value="P:asparagine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07572">
        <property type="entry name" value="nit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.110.10:FF:000002">
        <property type="entry name" value="Nitrilase family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045254">
        <property type="entry name" value="Nit1/2_C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001110">
        <property type="entry name" value="UPF0012_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23088">
        <property type="entry name" value="NITRILASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23088:SF30">
        <property type="entry name" value="OMEGA-AMIDASE NIT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01227">
        <property type="entry name" value="UPF0012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="3">
        <location>
            <begin position="12"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PCH38779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="304" mass="33123" checksum="1D9EEF9F70FF1119" modified="2018-01-31" version="1">MSSSAAPAFKPFNLALIQLGQVGPDKAANLQHAREMILRAARGDGGAKPKADLVVLPECFNSPYGHVHFPVYAETIAFVPGRPYDVAASASKSVKMLSAAAREAGVWLVGGSIPERDTTDSKLYNTATVYSPQGDLVAIHRKVHLFDIDIPGKITFKESETLTGGKTINCFDTDFARVGLGICYDVRFPELAMINARRGCQVLIYPGAFNLTTGPLHWELLQRARAIDQQVYFSMCSPARDMTAGYHAWGHSMVVDPMGKVIAEAGHEEDIVYAHIDPQTFHDARAGIPVTTQRRFDVYADVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JJ60</accession>
    <name>A0A2H3JJ60_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="7">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WOLCODRAFT_137782</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 11">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="7"/>
    <dbReference type="EMBL" id="KB468124">
        <property type="protein sequence ID" value="PCH42240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JJ60"/>
    <dbReference type="STRING" id="742152.A0A2H3JJ60"/>
    <dbReference type="OMA" id="EGYNWGQ"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07415">
        <property type="entry name" value="MPP_PP2A_PP4_PP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000003">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="8">
        <location>
            <begin position="109"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PCH42240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="304" mass="34869" checksum="F53D60064DC0E173" modified="2018-01-31" version="1">MEHEIDAWVAQLSQCKQLSEADVKRLCDKTREILMEESNVQPVRCPVTVCGDIHGQFHDLSELFRIGGNSPDTNYLFMGDYVDRGYYSVETVTLLVALKLRYRDRVTILRGNHESRQITQVYGFYDECLRKYGNANVWRMFTDLFDYLPLTALIENQIFCLHGGLSPSIDTLDHVRGIDRVQEVPHEGPMCDLLWSDPDDRSGWGISPRGAGYTFGQDISQAFNHNNGLTLVARAHQLIMEGYNWSQDRNVVTIFSAPNYCYRCGNQAAIMEMDEKLSYSFLQFDPAPRVGEPLVTRRVPDYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JJ89</accession>
    <name>A0A2H3JJ89_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">A1pp-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_25227</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468124">
        <property type="protein sequence ID" value="PCH42242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JJ89"/>
    <dbReference type="STRING" id="742152.A0A2H3JJ89"/>
    <dbReference type="OMA" id="AKWVIHT"/>
    <dbReference type="OrthoDB" id="6077599at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02908">
        <property type="entry name" value="Macro_OAADPr_deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001664">
        <property type="entry name" value="PRK00431.1-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11106">
        <property type="entry name" value="GANGLIOSIDE INDUCED DIFFERENTIATION ASSOCIATED PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11106:SF27">
        <property type="entry name" value="MACRO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00506">
        <property type="entry name" value="A1pp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Macro" evidence="1">
        <location>
            <begin position="27"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH42242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="225" mass="24472" checksum="52088FED3868DB5B" modified="2018-01-31" version="1">MLVGLTKIPTLRDLYKASVLRAVELSKTRAQPKAPLLDRVSLYQGDITTLEVDAIVNAANRSLLGGSGVDGAIHAASGPGLLNECRKLNGCDTGDAKITKGYNLPSENVIHTVGPVYSSANADVQARLLQSCYRTSLQLAAQNSLKHIAFPSISTGIYGYPIEDATHIALDTVRQFLDSSHADKLERVVFVVWSDDDKEVYEDLIPVYFPKPSEYEDVQPLKSVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JJX8</accession>
    <name>A0A2H3JJX8_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein YAE1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Protein yae1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WOLCODRAFT_136699</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the YAE1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468053">
        <property type="protein sequence ID" value="PCH40163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JJX8"/>
    <dbReference type="STRING" id="742152.A0A2H3JJX8"/>
    <dbReference type="OMA" id="TEEAGWA"/>
    <dbReference type="OrthoDB" id="20086at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
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            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00007096"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00017286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09811"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH40163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="206" mass="22960" checksum="063EDC733B53DA69" modified="2018-01-31" version="1">MSRYEFVNPEQLTDDETIWAGDPKSLQDSEWSQVSSNFTNAGYREGITAGKESALQAAFDEGYATVGVPLGRELGVLRGVASALLSFLDKAGGDQHRQELVAELRAINAQLGEIRLSDIAPPDLEAIRHAREHLDAENDEEIDPMETNEELKEKRDMEKLEDMLTQMSAGATEPLSAARPTMDDVRRLKERLRFICGSLEINPQWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JJY6</accession>
    <name>A0A2H3JJY6_WOLCO</name>
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        <recommendedName>
            <fullName evidence="4">UbiA prenyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_143772</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468124">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
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        <location>
            <begin position="100"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH41865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="321" mass="34643" checksum="FD9F1F1234C733BD" modified="2018-01-31" version="1">MSPSMQSKDSAAEQLPVGKLTDELLGHPLALALGSLALSAFISHALFGRVDWRPILICTTSDILTIGLDHYHDHAALHALAAKSPAAPYNAAVLRVFTRARTLLVTAAALLVAALAAAPARTWALTALFVTPALLWDTPLFRFRRAPREKTDAARTAGGDGAFVIKRIPGMKALIIGVIRGCGTFMVVRSVLGAHGYALRAPWSPAQFVIWSTVNRACHAVMADIRDYPSDLAHGVPTLPVLLRSVLRTKILLTALHLGTMLAFARNAYIVLGAAYAVALVWALDERSARAWFRASFHSQTAVALVWAARCAVEEYRRGAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JKH5</accession>
    <name>A0A2H3JKH5_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_152082</name>
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    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="115"/>
        </location>
    </feature>
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        <location>
            <begin position="145"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="175"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH42035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="328" mass="35224" checksum="994DD7DA33008343" modified="2018-01-31" version="1">MDLLQQPPPPPAVEPQLPPGQPDDVDADADMGDIEQHYSILDHWGEAACCFVDPIRVGLAALKDVGMVSLDAGDLVRRVLQNASANYPPPGDTLDYGPPDVDVRPSTGSTQRDDVTSTVLTALQPLLRSMDRRFASIEACLRASDARPPGATSTRQRPAHQPNSDTPHPPNGTRSYATAASTEPSTPTQTKDPHGRAPPQTRPKPKGPAKPARWIVRFGNNPPPELHGRDPLLMARALRTRLAAIPTAAALTVLAVEQTVSGNLILSFTPTSPRRDVEMHIPTIRAALGLGPDVRISPDVPWSKLTLGFVPTRLSQDYSPGYPASYST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JKM8</accession>
    <name>A0A2H3JKM8_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Spindle assembly checkpoint component MAD1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WOLCODRAFT_138047</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAD1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468135">
        <property type="protein sequence ID" value="PCH42740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JKM8"/>
    <dbReference type="STRING" id="742152.A0A2H3JKM8"/>
    <dbReference type="OMA" id="YKLDFMP"/>
    <dbReference type="OrthoDB" id="331602at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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</entry>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
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                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
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                <person name="Sabat G."/>
                <person name="Salamov A."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <location>
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            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH37404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="83" mass="9097" checksum="BCBE1445023CCDD3" modified="2018-01-31" version="1">MTSKRVRRIPKGTNEYQATWIVDETDDEDEDGEGGSEVGKNDAQEEEEEEERRGAIASIQGLAKTADQRGRQAAASAYLGPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JM61</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
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                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <location>
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            <end position="35"/>
        </location>
    </feature>
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        <location>
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            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH37734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="122" mass="12929" checksum="B9CFAA0969EF7084" modified="2018-01-31" version="1">MSSSSTPPLGDANPILLRLPTPSRFNHRRRPLATTPDQSYALVSLAPSFVSSSLPAPASLIIDALFLPPSTPIARESPDAKPKAFPEKRRGGRAEHRAPLREAGPTRAVSSGAVVQPDATRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JM80</accession>
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            <fullName evidence="17">Pheromone-processing carboxypeptidase KEX1</fullName>
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        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Carboxypeptidase D</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Pheromone-processing carboxypeptidase kex1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">WOLCODRAFT_137115</name>
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        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
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            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
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                <person name="Lindquist E."/>
                <person name="Ling A."/>
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                <person name="Martin R."/>
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                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Preferential release of a C-terminal arginine or lysine residue.</text>
            <dbReference type="EC" id="3.4.16.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">trans-Golgi network membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.6" evidence="15"/>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH40983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="742152.A0A2H3JM80"/>
    <dbReference type="OMA" id="EMADQFV"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JMM5</accession>
    <name>A0A2H3JMM5_WOLCO</name>
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        <recommendedName>
            <fullName evidence="5">Fork-head domain-containing protein</fullName>
        </recommendedName>
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        <name evidence="6" type="ORF">WOLCODRAFT_137215</name>
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        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
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    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
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                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
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                <person name="St John F."/>
                <person name="Stenlid J."/>
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                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        </source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JMP5</accession>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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    </protein>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="PCH39008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JMP5"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH39008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="112" mass="11886" checksum="96494BBF8AD52765" modified="2018-01-31" version="1">MTSACARLLAGPTLHLYLLDCGEGLTCTLTSVAAGIRRLDFPAGAVPTYVRSYCVIVEVTEVTDAKVAEVTEVTEVADVEVMEVVEVADVEVVEVAEVAEVVEVMEVADARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JN10</accession>
    <name>A0A2H3JN10_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_153333</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468135">
        <property type="protein sequence ID" value="PCH43281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JN10"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH43281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="120" mass="12846" checksum="4E98AF8CD27F072E" modified="2018-01-31" version="1">MSHLRQSSATFLDLRKATEPQIRIHGVGSLTTAGGVSGMRTGSCGGVLVAFLRVSPLARRHVVGDDLVARIARAQSTSSSPHAACAREGESTEMVEGLLLHLDGDMDMLRSLELRCEVFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JNM0</accession>
    <name>A0A2H3JNM0_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">STE3-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WOLCODRAFT_141188</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467987">
        <property type="protein sequence ID" value="PCH39328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JNM0"/>
    <dbReference type="OMA" id="WRDNVIN"/>
    <dbReference type="OrthoDB" id="2874149at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004934">
        <property type="term" value="F:mating-type alpha-factor pheromone receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000750">
        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14966">
        <property type="entry name" value="7tmD_STE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000481">
        <property type="entry name" value="GPCR_Pheromne_B_alpha_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001499">
        <property type="entry name" value="GPCR_STE3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28097">
        <property type="entry name" value="PHEROMONE A FACTOR RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28097:SF1">
        <property type="entry name" value="PHEROMONE A FACTOR RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02076">
        <property type="entry name" value="STE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00899">
        <property type="entry name" value="GPCRSTE3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00901">
        <property type="entry name" value="PHEROMONEBAR"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0589">Pheromone response</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="208"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PCH39328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="458" mass="51677" checksum="71C311DAA29D0A3D" modified="2018-01-31" version="1">MDSSWAVQQNVVIAFSFIGFVLVNVPLYWHLEAWNTGCIIYIFWSGSQCLIQFINAVVWRDNVINWAPVWCDITSRYMLAASVGITTASLLINRRLYHIANITTIHLDAKDRRRMIVIDVSIGLGLPILQVLVYWFIQGHRFDIFEGFGCFYAIPNTILSWFLCDIWPIVIGCISAVYCVLTIRAFLRRRKQLSELVAANSNLDFNRYFRLMAIAAVEVCFTVPLGIYSMVQNATGYIYPWTGLANLHYQFSAVDQIPAFLWRADPQVAQGLAFTRWSFIGTALLFFALFGLAAEARKHYRDAYVAVCSRVGVRTDFYTGLSSRLGIGRPWKSFVSSFSRSKSDITMPAVTIDTFIQKSRPHSIRTFSDKLSVSISLTDVDSAHSIKLASPASYSSTCVADSPADDKSLAMRERRDVPLPSLPSLDLEPEFVLDISRVMMERPLPDVPPSVRHSVDIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JNS3</accession>
    <name>A0A2H3JNS3_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tripeptidyl-peptidase II</fullName>
            <ecNumber evidence="4">3.4.14.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">WOLCODRAFT_122691</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Secreted tripeptidyl-peptidase which degrades proteins at acidic pHs and is involved in virulence.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal tripeptide from a polypeptide.</text>
            <dbReference type="EC" id="3.4.14.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="15">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
            <location evidence="3">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.4.14.10" evidence="4"/>
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        <property type="protein sequence ID" value="PCH43830.1"/>
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            <begin position="212"/>
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        <location>
            <position position="528"/>
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        <ligand>
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        <location>
            <position position="529"/>
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</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JP68</accession>
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        <name evidence="3" type="ORF">WOLCODRAFT_159111</name>
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        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
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                <person name="Stenlid J."/>
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                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">MD-104</strain>
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</entry>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
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                <person name="Ferreira P."/>
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                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
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                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
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                <person name="Nagy L.G."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
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    </dbReference>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="177" mass="19501" checksum="FCD59E8BD0BA61A4" modified="2018-01-31" version="1">MEGVSHDFGSSTQTLGSKSRTTASSVLWGHLLTKGSSASSIQRTSQGSSASSLAPIAPMDKAGTSLRVLLHDTQATLEKFSSRVDALTGGVDQSRREIMTVQKLFQQDREKMVDETVDLVNRCQREIQKAVGSPAQVSRVDEIHAELVAVDRRLETLDKRIDMLQMVWSCHMHCFVL</sequence>
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            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
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                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
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    </evidence>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
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                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
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                <person name="Benoit I."/>
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                <person name="Ferreira P."/>
                <person name="Findley K."/>
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                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
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                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
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                <person name="Lindquist E."/>
                <person name="Ling A."/>
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                <person name="Murat C."/>
                <person name="Nagy L.G."/>
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    <dbReference type="PANTHER" id="PTHR10328:SF15">
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            <strain evidence="1 2">MD-104</strain>
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        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="74" mass="7845" checksum="693A2CF3CC4B1F42" modified="2018-01-31" version="1">MSDLFCSANPLPPSHPYAAAHAKHGAYYAMQHVSDIEPFKTSTLAGGCAQVASPDSGSALCRYIPSEYAREGDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JRN4</accession>
    <name>A0A2H3JRN4_WOLCO</name>
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        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="1" type="ORF">WOLCODRAFT_165417</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468168">
        <property type="protein sequence ID" value="PCH44812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JRN4"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH44812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="499" mass="56875" checksum="148E6F751D116B3D" modified="2018-01-31" version="1">MRAAVIRYRKYDIDVFIEIDALQRKVGKSSVDKQRRALNHHVNWHSRFILQLKREINKLSPISVLPPEILEKIFITHTKIVWQETDAEWKQSLSLDVTQELIARFKALPLTIRLDFDWEDSDLSLPLILWEFERIRQLEIFANLSDVPYRLLCSDEEISGSPTPLLQQLLRNTRNYDTYTNDERLRVIASTLSSHASSPQLTRLVLHSWPFDWAQITPLSMLRHLDITFERTGQSERARERRDGKAEFDALLVAVKLLPLLESLCIRGCFLLRRDSFEWNVIPNRMVTLSHLRHLCLKDGASACATTLSHLTLPVLSTLNVNIADGHDLEETDAERVLVHLAHGIIEQVRGMGEAHSVNMCRSSLRVSYVAGPNQQASGKLYIYFGDLRESCEVRLCPELSSTVAAMTVRDVSVDGGCLLYMDVWGALIGRMPNATNLQVNSPSRKALEALGQPSIAAHPPSINPDRQEDELATGYPFPRLRFLTLVNPDFSWPSWMPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JSK2</accession>
    <name>A0A2H3JSK2_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WOLCODRAFT_139400</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG7 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468168">
        <property type="protein sequence ID" value="PCH45130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JSK2"/>
    <dbReference type="STRING" id="742152.A0A2H3JSK2"/>
    <dbReference type="OMA" id="LKYYHNC"/>
    <dbReference type="OrthoDB" id="249612at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019335">
        <property type="entry name" value="COG7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21443">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21443:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10191">
        <property type="entry name" value="COG7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="371"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="636"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="916"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="390"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="927"/>
            <end position="950"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PCH45130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="965" mass="104621" checksum="BBE3FE501A82B2AF" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JSQ7</accession>
    <name>A0A2H3JSQ7_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WOLCODRAFT_137011</name>
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    <organism evidence="8 9">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH40808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JSQ7"/>
    <dbReference type="STRING" id="742152.A0A2H3JSQ7"/>
    <dbReference type="OMA" id="LICEHTF"/>
    <dbReference type="OrthoDB" id="1923159at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16564">
        <property type="entry name" value="RING-HC_RNF222"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="171"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
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            <begin position="247"/>
            <end position="402"/>
        </location>
    </feature>
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        <location>
            <begin position="40"/>
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        </location>
    </feature>
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            <end position="269"/>
        </location>
    </feature>
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            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
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            <begin position="320"/>
            <end position="332"/>
        </location>
    </feature>
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            <begin position="333"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="384"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH40808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="417" mass="46098" checksum="EB1590785AA95B79" modified="2018-01-31" version="1">MPPRTRSHGNADTAVHSPQNGSESSDSEGDKSEDQLEVHLTRALRGAEKARKELEALRKRNAELERRLATIEEAEGASVQPKRGRKGGPTVAKLQGEIRKLNNKLITLEKAKQKDRKKIEKLRLKEVKADAQDLEEAAEFEVGDSAYRMRKLLRRFHDIIVSSSIEENEECPICLETVQVNKCASLICEHTFCETCLSQISPESEIVTCPQCRKPCPRDEIETVQYTASQQWDALLEVAQAWAKMDLRRQEDTSEEEAEEEFIDDEPPDDVAASASRSASENPLASSPEPQEPHAGSSHVDMDLLDAPATMPNKKRRVAVSPESSPLSHVSSTNNDPQNTTEPHNSRDQLPNSDISLDNVSQKDEEAVAGPSNAPVPGTPPPAQASTPTTPSYSQSPVADRRKRLQELAAARKRKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JST7</accession>
    <name>A0A2H3JST7_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_85055</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
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    <dbReference type="Proteomes" id="UP000218811">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR35871:SF1">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH39107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="119" mass="14179" checksum="51B215ADECA39F84" modified="2018-01-31" version="1" fragment="single">ITVCTTQRWLRKLDWQYWQKSNGMYIDGYEHDDVIEYQSTFIKRWAEYEKHMVTYDNDGNIKGLQSLRSILQLSFLYLVTHDESTFYANDHCKTKWIHSSEKSAPQRKGEGALLMVSDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JSU5</accession>
    <name>A0A2H3JSU5_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Endopeptidase S2P</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WOLCODRAFT_17384</name>
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    <organism evidence="8 9">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
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            <taxon>Phaeolaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="PCH41919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OMA" id="GFDGAHI"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031293">
        <property type="term" value="P:membrane protein intracellular domain proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905897">
        <property type="term" value="P:regulation of response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001193">
        <property type="entry name" value="MBTPS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008915">
        <property type="entry name" value="Peptidase_M50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13325:SF3">
        <property type="entry name" value="MEMBRANE-BOUND TRANSCRIPTION FACTOR SITE-2 PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13325">
        <property type="entry name" value="PROTEASE M50 MEMBRANE-BOUND TRANSCRIPTION FACTOR SITE 2 PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02163">
        <property type="entry name" value="Peptidase_M50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01000">
        <property type="entry name" value="SREBPS2PTASE"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M50" evidence="7">
        <location>
            <begin position="163"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PCH41919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="441" mass="47657" checksum="0876BA8B580B4860" modified="2018-01-31" version="1">MGPLADEIKSLIVWTCVLWVCLHLVHRFSPRRSSRTVLPLALTSATRTEVSLQGVHLRVSTTALNNYFSRRNVDRTKHRRIYDAGSVAGVLGLGTALGLLVFTTFQMTMSHSSAHNTSAQLGKRDLSPEIPPSGSDYARNYDTPLQLIIPGVTVPLAHLPILLFTLLSSQVFHEAGHAFAAAIESIPVLSTGASLTLLIPSAFVSLPTAAVSALPARARLRIASAGAFHNLALWLALIVLARVPLHALLGYADVGAWGAVVIAVEERSPLQAHLPVGSVITHVDDEPLTEPSWPTLLLQSPASDMQDNLGWCAQRPWFEEQPAACCATTASPELACFVAAEPARMERCADPLPFLGGADARRCASAADCGAHHVCVHPRADEALVRLAVRPPPWTHDPAERVVVWRGPRSEILEEVEVSKWAPRWRYSPVTLPSILDAIMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JT25</accession>
    <name>A0A2H3JT25_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tf2-1-like SH3-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_57995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
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                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
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                <person name="St John F."/>
                <person name="Stenlid J."/>
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                <person name="Sun S."/>
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                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="PCH42029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    </dbReference>
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    </feature>
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            <position position="1"/>
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    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
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    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH42029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="92" mass="10351" checksum="DBB617CD28F701FE" modified="2018-01-31" version="1" fragment="single">VGDKVMIDARDYQSTEQSLAPRYIRPFKIVEKLSPVTFRLHLGAQYCAYNPAFHASELVPYSSNVTRNPLGRPAPLLAPGEDQEYEVESILN</sequence>
</entry>
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            <fullName evidence="4">Eukaryotic translation initiation factor 3 30 kDa subunit</fullName>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
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                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
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                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
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                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6 7">MD-104</strain>
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    </evidence>
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    </evidence>
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    </evidence>
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                <person name="Ohm R.A."/>
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                <person name="Rokas A."/>
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                <person name="Sabat G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">MD-104</strain>
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        </location>
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        </source>
    </evidence>
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        <source>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
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                <person name="Barry K."/>
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                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
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                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
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                <person name="Lundell T."/>
                <person name="Martin R."/>
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                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
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                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
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                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
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            <dbReference type="DOI" id="10.1126/science.1221748"/>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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            <dbReference type="DOI" id="10.1126/science.1221748"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        </source>
    </evidence>
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    </evidence>
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                <person name="Binder M."/>
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                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
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                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
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                <person name="Benoit I."/>
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                <person name="Ferreira P."/>
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                <person name="Heitman J."/>
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                <person name="Kallen N."/>
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                <person name="Kumar T.K.A."/>
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                <person name="Nagy L.G."/>
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        </citation>
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        </source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
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                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
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                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
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                <person name="Nagy L.G."/>
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            <strain evidence="7 8">MD-104</strain>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </evidence>
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                <person name="Kallen N."/>
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                <person name="Kohler A."/>
                <person name="Kuees U."/>
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                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
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                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468146">
        <property type="protein sequence ID" value="PCH43427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="742152.A0A2H3K4T6"/>
    <dbReference type="OrthoDB" id="2803628at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
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                <person name="Nagy L.G."/>
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                <person name="Ohm R.A."/>
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        </source>
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</entry>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RdRP family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.48" evidence="1"/>
    <dbReference type="EMBL" id="KB468168">
        <property type="protein sequence ID" value="PCH44937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K916"/>
    <dbReference type="STRING" id="742152.A0A2H3K916"/>
    <dbReference type="OMA" id="QWELARY"/>
    <dbReference type="OrthoDB" id="10055769at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031380">
        <property type="term" value="C:nuclear RNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007855">
        <property type="entry name" value="RDRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057596">
        <property type="entry name" value="RDRP_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079">
        <property type="entry name" value="RNA-DEPENDENT RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079:SF55">
        <property type="entry name" value="RNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05183">
        <property type="entry name" value="RdRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0696">RNA-directed RNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RDRP core" evidence="2">
        <location>
            <begin position="338"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH44937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="671" mass="76493" checksum="018AD0CB8C37C7C9" modified="2018-01-31" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IT55</accession>
    <name>A0A2H3IT55_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal protein/NADH dehydrogenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WOLCODRAFT_93025</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH33160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="742152.A0A2H3IT55"/>
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    <dbReference type="OrthoDB" id="1696305at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007741">
        <property type="entry name" value="Ribosomal_mL43/mS25/NADH_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040049">
        <property type="entry name" value="Ribosomal_mS25/mL61"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13274">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13274:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00916">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein/NADH dehydrogenase" evidence="6">
        <location>
            <begin position="40"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PCH33160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="168" mass="19204" checksum="6D9426E72073EF59" modified="2018-01-31" version="1">MVPKSKAFPGPSRLSRIIVELQKEPRPHLNSVKSLKLTYAFRNDHFAARHFVKEDLPRIRHVNPSIGIEVVKIPKTPQDSWQPEMVVEFQNGTTQTLNMNKPWSSEILQELMDMAGGPSWQRWKKEREEAGLPILDPPKPREPKPQSVEDLLFARPHHQKTGAAAVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3ITG6</accession>
    <name>A0A2H3ITG6_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein mL43</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WOLCODRAFT_111552</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL43 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH33270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3ITG6"/>
    <dbReference type="STRING" id="742152.A0A2H3ITG6"/>
    <dbReference type="OMA" id="WPSSANT"/>
    <dbReference type="OrthoDB" id="88at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039927">
        <property type="entry name" value="Ribosomal_mL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007741">
        <property type="entry name" value="Ribosomal_mL43/mS25/NADH_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21396">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21396:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05047">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00916">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein/NADH dehydrogenase" evidence="7">
        <location>
            <begin position="41"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PCH33270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="148" mass="16861" checksum="168A2DE75AC0C50F" modified="2018-01-31" version="1">MAPKLTPTTRPLLRASLTSRPANGHVAFIPQIRKLVFEFCDRWPSSANTRKYIHDHLEELARANPHVEIVVKQRTNREPIVRGFYLNDRDKVIALNGFEVTGIQQKIQLLLDSSGAKIKPLKRRTVESTTEAARGIWSGLHVEEPFKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3ITS0</accession>
    <name>A0A2H3ITS0_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_135095</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH33372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3ITS0"/>
    <dbReference type="STRING" id="742152.A0A2H3ITS0"/>
    <dbReference type="OrthoDB" id="2745518at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH33372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="322" mass="37281" checksum="462155B3DCF96883" modified="2018-01-31" version="1">MRFHRAVYRFWLFCTSFCYPAREVPFQAGGEINHSEYHAQFLRPFSAEELLDIRRVADFCADMVGWVTDYQTITPRPVSAEQTAIFTAYCRSNAELAPDYALEIYRRLRIFHKQSHVRSFFWGAYDRAIAEKLPTTAQDREERLAKAILREVYGEHDTCHRCHAVGGLKLYGKTNWHWMRGEFNWTKLRGLLPGNLPPNKYEGGRLAQRACTPDGYARMMEEIFDARCASPQQMHAQAHAPGAGAWDAEGLYCAACVEVLLGERLWVWCDARQQRESDSVREDCCYGWGCRTQVHNIEHAEMLNHFCMPARDDSEDPESHRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IUH2</accession>
    <name>A0A2H3IUH2_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">vesicle-fusing ATPase</fullName>
            <ecNumber evidence="3">3.6.4.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">WOLCODRAFT_134884</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.6" evidence="3"/>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH33075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3IUH2"/>
    <dbReference type="STRING" id="742152.A0A2H3IUH2"/>
    <dbReference type="OMA" id="IEWTNEF"/>
    <dbReference type="OrthoDB" id="29072at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045324">
        <property type="term" value="P:late endosome to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02678">
        <property type="entry name" value="MIT_VPS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19521">
        <property type="entry name" value="RecA-like_VPS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.80:FF:000004">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000043">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000015">
        <property type="entry name" value="vacuolar protein sorting-associated protein 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007330">
        <property type="entry name" value="MIT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036181">
        <property type="entry name" value="MIT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050304">
        <property type="entry name" value="MT-severing_AAA_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015415">
        <property type="entry name" value="Spast_Vps4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045253">
        <property type="entry name" value="VPS4_MIT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074:SF83">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04212">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09336">
        <property type="entry name" value="Vps4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00745">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116846">
        <property type="entry name" value="MIT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MIT" evidence="15">
        <location>
            <begin position="2"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="14">
        <location>
            <begin position="164"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="84"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PCH33075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="434" mass="48392" checksum="8301939E120FEDAB" modified="2018-01-31" version="1">MTTTNLDRAIEIVQRAIDEDSKQNYAEAYKQYQNALDYFMLALKWEKNEKSKQLIRTKVTEYLARAEILKDHLANAQEKRAKKAIGVNGTSGGAGASGRSKDGDDEADPEVKKLRAGLAGAIISEKPNVKWDDVAGLEAAKESLKEAVILPIKFPELFTGKRTPWKGILLYGPPGTGKSYLAKAVATEAKGTFFSVSSSDLVSKWQGDSERLVRQLFEMARENKPAIIFIDEVDSLAGSRNEQESEGSRRIKTEFLVQMNGVGHDDTGVLVLGATNIPWQLDNAIKRRFEKRIYIPLPGVEARRQMFQLHVGDTPCELTPQDYRMLAERTDGYSGSDISVVVRDALMQPVRKVLSATHFKEVQKDGAIKWTPCSPGDPQAVEKSWTDLESHELFEPPLRLPDFLKSLDSVRPTVTTEDIKRHDQWTLDSGNEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IVQ2</accession>
    <name>A0A2H3IVQ2_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Splicing factor 3B subunit 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_63782</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SF3B5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH34070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3IVQ2"/>
    <dbReference type="STRING" id="742152.A0A2H3IVQ2"/>
    <dbReference type="OMA" id="YDRFNIH"/>
    <dbReference type="OrthoDB" id="274726at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009846">
        <property type="entry name" value="SF3b5/RDS3-10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017089">
        <property type="entry name" value="Splicing_factor_3B_subunit_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20978">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20978:SF0">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07189">
        <property type="entry name" value="SF3b10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037010">
        <property type="entry name" value="Splicing_factor_3B_subunit_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH34070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="85" mass="9505" checksum="5F651BC93BA4D28E" modified="2018-01-31" version="1" fragment="single">SSELRYTANTQLEHLHARYTGTGHADLTKYEWLTHQHRDTLASIVGHPTLASYLAIADGEAVGRTRFEMTERMLQPCGPPPAKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IW66</accession>
    <name>A0A2H3IW66_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Alkaline phytoceramidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WOLCODRAFT_95072</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD-104</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the alkaline ceramidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH34232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3IW66"/>
    <dbReference type="STRING" id="742152.A0A2H3IW66"/>
    <dbReference type="OMA" id="SIDWCEL"/>
    <dbReference type="OrthoDB" id="187171at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046514">
        <property type="term" value="P:ceramide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008901">
        <property type="entry name" value="ACER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46187">
        <property type="entry name" value="ALKALINE CERAMIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46187:SF3">
        <property type="entry name" value="ALKALINE CERAMIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05875">
        <property type="entry name" value="Ceramidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="192"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR608901-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR608901-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PCH34232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="287" mass="31871" checksum="B5EAB423828DB08B" modified="2018-01-31" version="1">MVVNNATVASLNHHFWGPVTATLDWCEANYQFSSYIAEAANTFSNLFTIAVALWGSYQATQQSLPHRYLVGYAGFGLVGVGSFVFHATLLFEAQLGDELPMVYVASYCCAILFDTAPGFGWDNSPAALLATVVMSFNVVFTWSYYINRNPIYHQVVFASLLGVIGVRTVHLLREPGIAKKVPDSVKSTISRLFSAGAATFAFGFFVWNLDNIFCDKVTGWKHSIGWPVAFLLEGHAWWHIFTAIGTYLMLIGNTCDTLCIKDDYRNYAINPIHGIPCIQHVKQKKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IXQ0</accession>
    <name>A0A2H3IXQ0_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome b5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WOLCODRAFT_139568</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD-104</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cytochrome b5 family. MAPR subfamily.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
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    </dbReference>
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        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
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        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
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        <property type="entry name" value="MAPR/NEUFC/NENF-like"/>
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    <dbReference type="PANTHER" id="PTHR10281">
        <property type="entry name" value="MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT-RELATED"/>
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        <location>
            <begin position="59"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
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        <source>
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    </evidence>
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            <dbReference type="EMBL" id="PCH34770.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="170" mass="19208" checksum="1CBAD7D17272F1BE" modified="2018-01-31" version="1">MSFALSTPVNTALLLYILYSLQRILLPSTTLPSEPPTEFKRGYSWMPRAHPPTLLFKTYTPHTLEPFNGEDGKRILLAIDGVVYDVTAGRNFYGPNGMYANFAGRDASRGMAKQSFDLEMLTPIDQPLDKLEDLTQEEIENMRGWQEHFSTKYIICGKLVENDVAEAQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IY68</accession>
    <name>A0A2H3IY68_WOLCO</name>
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        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
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    </protein>
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        <name evidence="9" type="ORF">WOLCODRAFT_165740</name>
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    <organism evidence="9 10">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
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        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
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                <person name="Samejima M."/>
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                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
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                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
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            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="MFS_MMR_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF9">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="187"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="448"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="476"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="531"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <begin position="187"/>
            <end position="642"/>
        </location>
    </feature>
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    </feature>
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    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="696"/>
            <end position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PCH34681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="709" mass="77060" checksum="73AFA758A94F2B7D" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IYU8</accession>
    <name>A0A2H3IYU8_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_166095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467843">
        <property type="protein sequence ID" value="PCH35172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3IYU8"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH35172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="163" mass="17311" checksum="A1D500A1B54DEAE3" modified="2018-01-31" version="1">MDKADDISGSDDVDEDDSEGQDEHRSYVWERRGDWNGRSVFKSSRAVSIHRDIPSARDRAPHLATPLIAPSYQPHPTTRPSRAASLAGCASQAHDACTDTAARHLGEAGHWPTAHALALDARKTPGGLGAIGGMDVWRAEVAGFDCFASSSAARAEADGPPEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IZ00</accession>
    <name>A0A2H3IZ00_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WOLCODRAFT_166132</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="KB467843">
        <property type="protein sequence ID" value="PCH35222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3IZ00"/>
    <dbReference type="STRING" id="742152.A0A2H3IZ00"/>
    <dbReference type="OMA" id="RCPAQAN"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142:SF3">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G09070)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="5"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PCH35222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="446" mass="48424" checksum="44DA95A060A0B4E0" modified="2018-01-31" version="1">MASAEALKPVLFFIHGGSFTQGTGADPMFDGGNMASRGDVVVVTINYRLSTIGFLALSDGTTNGNFGLADQVAALDWVQEHIVAFGGDPSRITISGQSAGAASVRALLGSPPAIGKFAGAVPQSNLAGADYATTYSLYYTIPEEVKLVVEPILNETGCQGANALECLRAYDAYALVNLTTVARFIVTDGTYVTSTELPLNGSGHVVRVHTMMGYMRDDGAAAIGYPTSGNLTAGLLEQELPIDVVNNTLFVPPTGENATLDVFNVTARVATDMEFRCLDQATAYSAVQHDLFESIWFYQFNRSYQDPAVDPNYPVCDAPVDATHPYGDPSRGYFKCHLGEMYYVFGTLPSTLPYRDSEDLPFTQLTVDAWSSFTRTYNPNPDPAFLLARGYNGTFAHVTHQEPWLPVTAETLRTTPLRTLQFDSFMGEFAEQEQCDFLGYPLDYFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IZD0</accession>
    <name>A0A2H3IZD0_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heme oxygenase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_107290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467843">
        <property type="protein sequence ID" value="PCH35352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3IZD0"/>
    <dbReference type="STRING" id="742152.A0A2H3IZD0"/>
    <dbReference type="OMA" id="AEWLAND"/>
    <dbReference type="OrthoDB" id="37730at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006772">
        <property type="term" value="P:thiamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19357">
        <property type="entry name" value="TenA_E_At3g16990-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053261">
        <property type="entry name" value="Polyketide-peptide_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004305">
        <property type="entry name" value="Thiaminase-2/PQQC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41813">
        <property type="entry name" value="REGULATOR PAB1642, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11955)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41813:SF2">
        <property type="entry name" value="REGULATOR PAB1642, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11955)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03070">
        <property type="entry name" value="TENA_THI-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thiaminase-2/PQQC" evidence="1">
        <location>
            <begin position="23"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH35352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="246" mass="26921" checksum="6699902EFF0C1073" modified="2018-01-31" version="1">MSTTETLTSHLLSLSTPRPYSAATTHSFLTAAGSGTLPPALLSLYLAQDRIFVAHAGIAFLGRLLAAVPSSSLDAPDSEAEQRSQRIVALLSRALQNAVREVGFFDEFARNWDLELKGWRERKATRDYTAELLRASIQAQGRIEDGLVFLWAMERLYLDAWTYVGSLTASSTGEESTAPAVAALVSNWTNPEFLRFVNDLTELVNSLGLEPGTSAWARAEATWMRVVELEEAFWPIGGEELSLLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IZG8</accession>
    <name>A0A2H3IZG8_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_155488</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
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                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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        </location>
    </feature>
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        <location>
            <begin position="266"/>
            <end position="330"/>
        </location>
    </feature>
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        <location>
            <begin position="344"/>
            <end position="379"/>
        </location>
    </feature>
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            <begin position="114"/>
            <end position="124"/>
        </location>
    </feature>
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        <location>
            <begin position="266"/>
            <end position="276"/>
        </location>
    </feature>
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        <location>
            <begin position="318"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="368"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH35265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="379" mass="43126" checksum="993A4B856E81572B" modified="2018-01-31" version="1">MTWTSPILIESIQADVREYARHIMNRRDSSSPLRDPPSAEELATYSRSGILDMTIDTFRVDFNGGAKSRWNAVAAEVFAEGFIASGWYECRDQERIQDAFMAHLKCLKSRYAEQQRGDDQDSPQKMHQRANNARNRRRISEHGHALDTLNRMALALPRNWKFIIGKRAFVALAAMLHNPAACKCDNPVINGQRKHRMPYASFTIIGKRIIDAGLRVLGLKPRNLTHHLGLGDRSDPGEPVDFGDAFKPWQQFEETDEWTDKKIVETEQKEQKERALAQHKSQAHTAPARQSERIREQQSVTSTSTSTSADRWTRNKHQTPYNPKQPRTVQHDVERSPLVIFMPPLQHPHAHGLGNGSKGRRDVLVDEGNQSSDLSSLED</sequence>
</entry>
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                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
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                <person name="Benoit I."/>
                <person name="Boyd A."/>
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                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
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                <person name="Kuo A."/>
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                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
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                <person name="Wiebenga A."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
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    </reference>
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    </dbReference>
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    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
    <sequence length="183" mass="19282" checksum="C213E2F995683840" modified="2018-01-31" version="1" fragment="single">RPALCKGEKSGASLGLMVLLCALPTLLSMPSQQSALPQTLPLSFTHPSSALASSALDMHSFLQSGPELDWSLGGVGADTDLSFDFDLGSSDERSRIASAAAAAAVSMSNRRLELVGVGRRLSQMYGNLQMPVPAVPCAPRIYPRSRRHVRGGAMGPYRVKSRTAIGDVGRRHLAELPDVAGGK</sequence>
</entry>
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                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">MD-104</strain>
        </source>
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    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
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    </evidence>
    <sequence length="80" mass="9177" checksum="C60210FF95BCB33B" modified="2018-01-31" version="1" fragment="single">MASLVRPTLGSRPLSLVSRPMPYRYRDCLCVVRVRHDAAPALSAPLRPMLVLYTRATSRRGDYYKLNARSHEEYIAWAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
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                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
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                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
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                <person name="Findley K."/>
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                <person name="Gorecki P."/>
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                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
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                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
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                <person name="Nolan M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">MD-104</strain>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR35871:SF1">
        <property type="entry name" value="CXC1-LIKE CYSTEINE CLUSTER ASSOCIATED WITH KDZ TRANSPOSASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35871">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH35916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="92" mass="11161" checksum="3E74CE810D43CC77" modified="2018-01-31" version="1" fragment="single">MIPAIAQEYLKEIVHREMPEGLKKYMELELFPQIHMKVGQGISLRTARDWLRCEGFRYIEHKKSLYYNGHERPDVVKYHQEFFLPTMAQHRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J1P3</accession>
    <name>A0A2H3J1P3_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acid protease</fullName>
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    <gene>
        <name evidence="7" type="ORF">WOLCODRAFT_108317</name>
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    <organism evidence="7 8">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
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        <lineage>
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            <taxon>Agaricomycetes</taxon>
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            <taxon>Phaeolaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Barry K."/>
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                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
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                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
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                <person name="Lucas S."/>
                <person name="Lundell T."/>
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                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
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                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
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                <person name="Sabat G."/>
                <person name="Salamov A."/>
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                <person name="Stenlid J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
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                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
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                <person name="Benoit I."/>
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                <person name="Ferreira P."/>
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                <person name="Gaskell J."/>
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                <person name="Heitman J."/>
                <person name="Hesse C."/>
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                <person name="Salamov A."/>
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                <person name="Schmutz J."/>
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                <person name="Stenlid J."/>
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                <person name="Sun S."/>
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                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
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                <person name="Pisabarro A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
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        <property type="protein sequence ID" value="PCH36931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J4Q8"/>
    <dbReference type="STRING" id="742152.A0A2H3J4Q8"/>
    <dbReference type="OMA" id="RWIRHIN"/>
    <dbReference type="OrthoDB" id="406156at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00682">
        <property type="entry name" value="IPNSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Non-haem dioxygenase N-terminal" evidence="2">
        <location>
            <begin position="29"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Isopenicillin N synthase-like Fe(2+) 2OG dioxygenase" evidence="1">
        <location>
            <begin position="192"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH36931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="355" mass="40370" checksum="11381B5D7F0D43A3" modified="2018-01-31" version="1">MPGSILPPVPQYNLPPPTKEPLEFADLAIVDLSKANTPEGRAELAIQVRDAMSKVGFFYAVNHGLSPSENKRVLDIADVPFTGVEDDEKQLYLAKIEELGTYQGYKLRNVWTVDAGVRDQVDNYNFNKNVYEREHPKAIRPFLPELDAFARFCHFNVVHQILRLMALGLELPEDTFIPNHRFSAPGDTYLRFMKYYPRSEDDEIKTKNVWMKGHTVGTVTALWSQPVSGLQIKSPDGNWRWVRHIDNALVINSGDAMEFFSGGFYKATIHRVVQPPADQRGYARLGVFYFGQPDNDAVLAPLTESPVLQRYGVRRRFEDADAPTMETYRTGRIRAFGLKELQKKENGVEETDITS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J4Q9</accession>
    <name>A0A2H3J4Q9_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_159523</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467910">
        <property type="protein sequence ID" value="PCH37220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J4Q9"/>
    <dbReference type="STRING" id="742152.A0A2H3J4Q9"/>
    <dbReference type="OMA" id="PGYLHAN"/>
    <dbReference type="OrthoDB" id="2426273at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39596">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39596:SF2">
        <property type="entry name" value="HET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G17550)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH37220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="228" mass="25677" checksum="011C64A01A96BB6B" modified="2018-01-31" version="1">MSGLTDLGAIPRPGYLHANIASLTTSLVPGGAFWMDSLCVPRQKDMRRKAIGLMVQTYRDAEIVLVIDAGIRSFSVNSSTEEKLLRVLMSEWMQRLWTLQETILSCKLVFEFAERTVSVEEVIPRNERDLLDVVPTKLASEIQRLCLKRRFIAGKLGIGDVSSFLRTRATNRSENETFAISSLLDVDAYELADLPHEKRMMTILTRLRNVPANIIFLSGSKLSEQGFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J536</accession>
    <name>A0A2H3J536_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WOLCODRAFT_83686</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467909">
        <property type="protein sequence ID" value="PCH37061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J536"/>
    <dbReference type="STRING" id="742152.A0A2H3J536"/>
    <dbReference type="OMA" id="ITIPCIV"/>
    <dbReference type="OrthoDB" id="6509908at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF177">
        <property type="entry name" value="RIBOFLAVIN TRANSPORTER MCH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="25"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="318"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="383"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PCH37061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="416" mass="45749" checksum="49FF9EE73A5BE917" modified="2018-01-31" version="1" fragment="single">IAPVSPKQSTEYTFPDGGWQAWRNVFGCFLLAVTSFGQLNAFGVFQTYYAANMLPNYSNSAISWIGSIQLTITYASGIVLGRIFDVYGARKTLVLGCILSTFCLMMTSISHKYYQLILSQGIGLGIGIALQFWLYSHSVQMIVPSHWFRMRRATATGIVLSGASLSGIIYPIMLSRLFSSVGFPWAVRAMAFMNFGLQALAIPMVKERLPHNAGNILIDYHAFKDITYLLHVISGFIISFGLYAPFWYLSLFSLSVGINFNLSFYMIAIMNAAGLIGRLSSGYLADWFGRFNITIPCIVLSAIAPLAIWTTSEGLAETIVFSVIFGFSSAAYSSIAASVTAQITADPTRIGMRIGMFILCCSEQFANCQVQSSAILASRHGDYIGLQIFIGIVMIAGAVFETVARLHRVPRIWCKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J5I1</accession>
    <name>A0A2H3J5I1_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein-S-isoprenylcysteine O-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WOLCODRAFT_167544</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD-104</strain>
        </source>
    </reference>
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        <reaction evidence="5">
            <text>[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + S-adenosyl-L-methionine = [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + S-adenosyl-L-homocysteine</text>
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            <dbReference type="Rhea" id="RHEA-COMP:12126"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90510"/>
            <dbReference type="ChEBI" id="CHEBI:90511"/>
            <dbReference type="EC" id="2.1.1.100"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
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        <property type="project" value="UniProtKB-KW"/>
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            <end position="146"/>
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    </feature>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU362022"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH37502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
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    </evidence>
    <sequence length="179" mass="19927" checksum="D6ECAC07667BB4AC" modified="2018-01-31" version="1">MWLVVLCETATIIANERSSAGVLQILTPSGAECTSRIAITPTFLIGMALQVVGGIIRKLCYRTLGRHFTFELSLRENHQLVTSGPYSIVRHPSYTGITMVFAGMLMCQLGAGSWLAECGMMNSIMGRIAVCGWVAHHLYVTATLLARMGKEDEVLKREFGPQWEQWARKTRHRLIPGVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J5W0</accession>
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        <recommendedName>
            <fullName evidence="12">ER transporter 6TM N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WOLCODRAFT_140699</name>
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    <organism evidence="10 11">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
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            <taxon>Agaricomycetes</taxon>
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    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
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                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
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                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
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                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
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                <person name="Stenlid J."/>
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                <person name="Sun S."/>
                <person name="Syed K."/>
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                <person name="Wiebenga A."/>
                <person name="Young D."/>
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                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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        <property type="protein sequence ID" value="PCH37055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="entry name" value="ArAE_2_N"/>
    </dbReference>
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        <property type="entry name" value="BRE4-related_DUF2421"/>
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    <dbReference type="InterPro" id="IPR049453">
        <property type="entry name" value="Memb_transporter_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37994">
        <property type="entry name" value="ARAE_2_N DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37994:SF3">
        <property type="entry name" value="ER TRANSPORTER 6TM N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10337">
        <property type="entry name" value="ArAE_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BRE4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FUSC_2"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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    <feature type="transmembrane region" description="Helical" evidence="6">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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    <feature type="transmembrane region" description="Helical" evidence="6">
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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        <location>
            <begin position="34"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="Integral membrane bound transporter" evidence="9">
        <location>
            <begin position="657"/>
            <end position="790"/>
        </location>
    </feature>
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        <location>
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            <end position="1025"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
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    </feature>
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        <location>
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    </feature>
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        <location>
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            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10334"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF10337"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF13515"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH37055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1044" mass="113886" checksum="38759D98C9581A9A" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
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    <name>A0A2H3J6D2_WOLCO</name>
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        <recommendedName>
            <fullName evidence="5">IRG-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="6" type="ORF">WOLCODRAFT_167389</name>
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            <taxon>Phaeolaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family.</text>
    </comment>
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        <property type="protein sequence ID" value="PCH37215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="422720at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030385">
        <property type="entry name" value="G_IRG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007743">
        <property type="entry name" value="Immunity-related_GTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051515">
        <property type="entry name" value="IRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32341">
        <property type="entry name" value="INTERFERON-INDUCIBLE GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32341:SF10">
        <property type="entry name" value="INTERFERON-INDUCIBLE GTPASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05049">
        <property type="entry name" value="IIGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51716">
        <property type="entry name" value="G_IRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IRG-type G" evidence="5">
        <location>
            <begin position="64"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PCH37215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="283" mass="32511" checksum="15A118AD3484E9F0" modified="2018-01-31" version="1">MLRNVFRRIERFVLWWTLSEEEERDYNEWKNNKMKPSHGVQAPIVIPTDDEMMEATKRYQYQYGKRHIAVSGATGCGKSTFINAIRGLGNRDSDSGVRIAPTGVTETTREFGCYPDPKTSDIWYDIPGAGTLSIPAEKYFNTQGLFVFDCIIILFDSRFTETDIAILKRCAYFNIPYFLVRAKSALHIQNFISDLRDDEDYEGWDESRLKMTAQSKFINETWSNVTNNLARAGLQPPQRVYCIDRSALIPCCRGEAGSTSENVIDEIDLIKAIRELPLRKLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J6F2</accession>
    <name>A0A2H3J6F2_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">WOLCODRAFT_167398</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467920">
        <property type="protein sequence ID" value="PCH37235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="304"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH37235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="353" mass="38533" checksum="02ED8C269873F115" modified="2018-01-31" version="1">MLDVAGVGPILIVAGGFYDGKSVTVEPLTRPCLMMEDDTGKRQQELARVLYASFDAVRAFRGLLETPLSTTYAFGTPRVYPSFCRLDTGRETLLQFEERLIPVDTSHHLLFSGKCRDPSTLTWDKVAVKLVMNYGSEVHRFLAGHNLAPILYGSVAAVGAPTAYVMSLLGKEWVTLLDYRSRLPSDASTFTNAITAGLNKVLEVLESKDYVHGDLRDNNIMILVDAERHPVLDAGQAQLRVIDFNWAGNAGEVQYPAQRNDSIEGWPGRAGDLIKAGHDRQLTPISPPVARTNMDADPGGSLKLLSWANVGLAFSFIVFDGIISVTFVGSARASGAAHKCDLVATAREQLRPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J6Y2</accession>
    <name>A0A2H3J6Y2_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_29082</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
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            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
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                <person name="St John F."/>
                <person name="Stenlid J."/>
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                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467931">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH37405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="63" mass="7406" checksum="2A7DEBB8746EA308" modified="2018-01-31" version="1">MTSTILMGLRRRWKSDSKVQAHWMRERENLSKTEFNLRRPPSGNAIRPFLILSGVLILHVRGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J7J1</accession>
    <name>A0A2H3J7J1_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
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        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
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        <lineage>
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            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH38210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J7J1"/>
    <dbReference type="STRING" id="742152.A0A2H3J7J1"/>
    <dbReference type="OrthoDB" id="341421at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF47">
        <property type="entry name" value="ACTIN-HISTIDINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PCH38210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="241" mass="27642" checksum="80A84F180068C435" modified="2018-01-31" version="1">MDSALPDYLWAWLNGRHRLTLCFTILTSWPSVNTRCIHYPVREPRTDEDNQTLCPILDFANHSENNSQIVPIINARSSVPKAGARQRSDDYRFVSCADSSIAKGQQLFLRYGGHANRTLFVEYGFVNHFEANAIIHGGFRGELDLQDSVEELLGKSLHDLHYPFIRRALEDEGYWGYHTLLFTHSRKPLMNASAGSGHLTQALHPRIRRIASLLRCVSSIWQKTRRPEALRSVLYSRGEMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J7W9</accession>
    <name>A0A2H3J7W9_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF1264-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_130641</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OBAP family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH38041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J7W9"/>
    <dbReference type="STRING" id="742152.A0A2H3J7W9"/>
    <dbReference type="OMA" id="RHVEAHH"/>
    <dbReference type="OrthoDB" id="1901244at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010686">
        <property type="entry name" value="OBAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31360:SF0">
        <property type="entry name" value="OIL BODY-ASSOCIATED PROTEIN 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06884">
        <property type="entry name" value="DUF1264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="182"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="182"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH38041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="234" mass="26899" checksum="9B410D80C903B993" modified="2018-01-31" version="1">MNPETKASMYHATPYMAAGSAMMTFKPINAIHQHLCAFHVYSQDRTRHIEAHHYCTHLRHDFHQCIIYDSDQPNAKLIGIEYIVSEQVFDSLPEAEKEFWHSHKFEVESGYMQMHTKDVIPNAVTDLAEQPAILEIHKTYGKTIHTWPVDISPDLPIGPPNIMVSYTGDGQGPPPEMIKQRDERCGMDTEGKRKLRAGYLPPYETRKDADQWQQTDKGLVFEAREVDYKPYTGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J846</accession>
    <name>A0A2H3J846_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_136246</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH38396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J846"/>
    <dbReference type="OMA" id="WTATDLW"/>
    <dbReference type="OrthoDB" id="3192156at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH38396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="301" mass="32525" checksum="B6F0C253E11AA7C4" modified="2018-01-31" version="1">MDLLLAPFVEVYRYALEPIAPFTWFGLSFSTLDVAAALRTCIALRQIKEQYYAHHLAKKRGSNEAAIQDIEHRSFVRDVSAALMVVFGGEAITGPALGAPCSFMISGKGPAFYTAIQAVVDRIPVIPAPSLFGELPVSILDGFTRAFLLCSLVPPMIVDHSSEAVSTSPWSLLVTAIITANGGWFFVNMFSFLQPYALTITTPPELMPNGWTATDLWCAPLITGLYALLTHAQPFWADAHAVVSGWLGAAGSEKVQPVDPEYARALCAAVLAVMFTTRTIKTFGFAQAKVKPVTGPKTKVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J8N3</accession>
    <name>A0A2H3J8N3_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Calcipressin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_136337</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RCAN family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH38566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J8N3"/>
    <dbReference type="STRING" id="742152.A0A2H3J8N3"/>
    <dbReference type="OMA" id="HTWAPIK"/>
    <dbReference type="OrthoDB" id="17212at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008597">
        <property type="term" value="F:calcium-dependent protein serine/threonine phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019722">
        <property type="term" value="P:calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006931">
        <property type="entry name" value="Calcipressin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10300">
        <property type="entry name" value="CALCIPRESSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10300:SF14">
        <property type="entry name" value="PROTEIN SARAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04847">
        <property type="entry name" value="Calcipressin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="203"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH38566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="243" mass="26590" checksum="50AF52CCDD65BDB5" modified="2018-01-31" version="1">MSPTHSPTVTTPPSLTSNSGPPTPRRTNTLVITQLPPSFFEPSVLETLHSHFATYGPLYAWAPLKSFARIMVVYYSGDDAEHAKEGCDQLLINAFDTNPAITLRVYRADPTPIVSSEHDNDKYLRPPEIEKNFLISPPGSPPVGWEPVREDPPNATPLAEDLIAALRKLQVQEEARSRGPGVEVLLEPEGDGVGISVYVEDCDGGEDGRAHEEEEEWVYGETAPARARWKPAPTTRPPMSVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J8V0</accession>
    <name>A0A2H3J8V0_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">mRNA transport regulator 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WOLCODRAFT_114728</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH38055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J8V0"/>
    <dbReference type="STRING" id="742152.A0A2H3J8V0"/>
    <dbReference type="OMA" id="MCCVYGP"/>
    <dbReference type="OrthoDB" id="2504340at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11371">
        <property type="entry name" value="RNase_PH_MTR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050080">
        <property type="entry name" value="RNase_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953:SF2">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT MTR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0271">Exosome</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="10">
        <location>
            <begin position="44"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PCH38055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="259" mass="28086" checksum="07811A9B67A99889" modified="2018-01-31" version="1">MASGNFDRRRINGPEESYPPVFEVEDDQPPRVRSVRQGRAAEDIRPIYLKAGLISQANGSAYIETERTKIACAVYGPRQSKTTVYNENGRLNVEVKFAPFSCTRRRVPIRDAEDRSVAMQIHQALLPAVRLELLPKSTIDIFITVIENDGIEGCIASGSVAASAALADAGVEMLGLVMSCAASTIGKEMWLDPTEDEAQSASGNLIFAGIPALGTITNIWQSGHMLPEQAFQCIEACQERCGDIHAVVAQALLDKAKIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J8Z1</accession>
    <name>A0A2H3J8Z1_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">WOLCODRAFT_65068</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">MD-104</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH38732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J8Z1"/>
    <dbReference type="STRING" id="742152.A0A2H3J8Z1"/>
    <dbReference type="OMA" id="ENIHRKQ"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
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    <sequence length="521" mass="59159" checksum="B75CE2A3E8177F62" modified="2018-01-31" version="1"> </sequence>
</entry>
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    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
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                <person name="Morgenstern I."/>
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                <person name="Ohm R.A."/>
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                <person name="St John F."/>
                <person name="Stenlid J."/>
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                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Yadav J.S."/>
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                <person name="Benoit I."/>
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                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
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                <person name="Sabat G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
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</entry>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="PCH35829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A2H3JAQ3"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="117"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH35829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="150" mass="16025" checksum="502840F47734E2D5" modified="2018-01-31" version="1">MSNGKLDRVIHLYCCMKSATQATIEPETYLKPTPIGSTAAGSEWAALMKSFTCTSLKKIRKVIADEESDGGDKIAVVATAAPEAAADTTEITAHNADVPVQANEQANLLRQPVVETTNPLPDLTDLTSEEPQVPAFCEGKLGDHSRDQTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JAX5</accession>
    <name>A0A2H3JAX5_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Autophagy-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WOLCODRAFT_165839</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Vacuolar effluxer which mediate the efflux of amino acids resulting from autophagic degradation. The release of autophagic amino acids allows the maintenance of protein synthesis and viability during nitrogen starvation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Vacuole membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ATG22 family.</text>
    </comment>
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        <property type="protein sequence ID" value="PCH34818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JAX5"/>
    <dbReference type="STRING" id="742152.A0A2H3JAX5"/>
    <dbReference type="OMA" id="QPWEIFP"/>
    <dbReference type="OrthoDB" id="192733at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032974">
        <property type="term" value="P:amino acid transmembrane export from vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17483">
        <property type="entry name" value="MFS_Atg22_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044738">
        <property type="entry name" value="Atg22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024671">
        <property type="entry name" value="Atg22-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050495">
        <property type="entry name" value="ATG22/LtaA_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519:SF1">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11700">
        <property type="entry name" value="ATG22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="8 10" id="KW-0072">Autophagy</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <keyword evidence="4 10" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="161"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="301"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="376"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="408"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="441"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="478"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="512"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="541"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="210"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="210"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="221"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PCH34818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="580" mass="63185" checksum="8720F6061CBD6CC2" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JB75</accession>
    <name>A0A2H3JB75_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Alpha/beta-hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WOLCODRAFT_94475</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lipid droplet</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. LDAH family.</text>
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        <property type="protein sequence ID" value="PCH33924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="742152.A0A2H3JB75"/>
    <dbReference type="OMA" id="WVPVSYY"/>
    <dbReference type="OrthoDB" id="448051at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019915">
        <property type="term" value="P:lipid storage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019363">
        <property type="entry name" value="LDAH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13390">
        <property type="entry name" value="LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13390:SF0">
        <property type="entry name" value="LIPID DROPLET-ASSOCIATED HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10230">
        <property type="entry name" value="LIDHydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0551">Lipid droplet</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022677"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="322" mass="35810" checksum="F59FE74A4FD49C61" modified="2018-01-31" version="1">MTTLPSFLRPVDSPQDSGIREPCINATFYHKSLDAAAHALWWPSSGDDPSTILLFIPGNPGLIEFYVPFLTSVHEKSQGRLAVLAHAHLGHSPTIPDGDVFKDTSTIGLTTQVQSAIEAVDTVSSSFPRSKIAIAAHSMGCWVTCQVLKARPDAVATVFWLFPTITNIVDTPNGRSLWWLFRPPLSQAISAMSIVTRVLPDRLLSALFPDWPLPQLRVLRTLLNSPSAIQACLTLANDEMNTIKDLDITLLQKYRHRIHLYFAQTDDWVGKNRETILRAFHADPDSVKIVYGQQDIPHAFCINHGEHLAEQCSEWLQQGGFI</sequence>
</entry>
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    <accession>A0A2H3JBP4</accession>
    <name>A0A2H3JBP4_WOLCO</name>
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        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD-104</strain>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="match status" value="1"/>
    </dbReference>
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</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Spatafora J.W."/>
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                <person name="Benoit I."/>
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                <person name="Ferreira P."/>
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                <person name="Heitman J."/>
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                <person name="Kallen N."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">MD-104</strain>
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    </reference>
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    </feature>
    <evidence type="ECO:0000313" key="1">
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="192" mass="21399" checksum="EDEED2B0906393FB" modified="2018-01-31" version="1" fragment="single">MTTMAGRHCQMTCVPTQTSCRHCTISPTQNIGRERMIGHGVTVFKIWTRTGAQYYLQLPTHILTGSTLNASSMARSAVISRDSDSQSVAVALVINGYLGTMPISPSLAISLRSLELLYTIRLFKASFSIESFGKLMCHLYKVPFKQRFRALVADAFEIYLIIRRNVNKQVLAALGRDAPNWRTLNSCPACCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JCA5</accession>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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        <location>
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        <location>
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                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="63"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH40656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="268" mass="30818" checksum="5C2CD9130F4D3A81" modified="2018-01-31" version="1">MPKDTSCGIGKYVLAKHDPTGRTERWEVPSPLPPHIAVVGKPIRKSRKGTKPYKLRERSPGELAELSAEMQEYHKQCAELNKLMAQRHEIEKKLAAKRRALKTVPLEQRLSSPVQGPSVPDNHHILDQSLKFGKTIYLRAAEHIRSTLLATLTRLTPLYNKGRDYANYDAYYDIKFDQMVIQLDDLLEHLRERARSGRITRKMWRVMKKDCNRIGRVSLERMDQRMAEIIKELAELKISFEYGVPEPEKVAGSSTVTTVDEDILMSIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JF15</accession>
    <name>A0A2H3JF15_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kinase-like protein</fullName>
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        <name evidence="2" type="ORF">WOLCODRAFT_30267</name>
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        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
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            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Phaeolaceae</taxon>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
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        <property type="entry name" value="Ser/Thr_kinase_AS"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00069">
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    </dbReference>
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            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH38393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="94" mass="10625" checksum="CB5872C4C3036515" modified="2018-01-31" version="1" fragment="single">LSQDLAKGLTFIHKNGIAHLDIKPANLVYTDEHRLQIIDFDIAVQVKDEDDLMCGYLGTEGWMAPEIGKKDGPHPLYSPIRADRWSCGRVFLVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JFV5</accession>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
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                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
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                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
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                <person name="Martin F."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="PCH41082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="120" mass="13423" checksum="063119E90931B66D" modified="2018-01-31" version="1">MSRSESTLLRECGVPSASSSYQNLQVISRERLHASLPVFPPNESGTAVNSVDDLHARSYMSHVPGLLPTRAELPPRCHSASSSASRPRRRCEAFTSMWNDVKFAGLRVRVKFSRMFRTES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JGI4</accession>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
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                <person name="Schmutz J."/>
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                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
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                <person name="Cullen D."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038737">
        <property type="entry name" value="SF3b_su1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12097">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH41286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
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                <person name="Heitman J."/>
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</entry>
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            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">MD-104</strain>
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    <comment type="function">
        <text evidence="11 14">Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the first dolichyl beta-D-mannosyl phosphate derived mannose in an alpha-1,3 linkage to Man(5)GlcNAc(2)-PP-dolichol to produce Man(6)GlcNAc(2)-PP-dolichol.</text>
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            <text>an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate = an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
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        <text evidence="2 14">Protein modification; protein glycosylation.</text>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="419" mass="47275" checksum="7FF659971DE1150B" modified="2018-01-31" version="1">MPTTNHLLGRLYQLVRSLLTDPRYFYVLATLVVAGDAVLTQLIIRFVPYTEIDWETYIYQLELYLKGERDYSLISGPTGPIVYPAGHVHVHHFLYNITDSGNKLAIAQQAYAALYLVYLSLTCVTYGQAGGVPNWIMLLLPLSKRLHSIFVLRLFNDCWTVAAVHAAVLAYGRGLDIVGTLLFGFALSVKMSALLYLPGLLVVLFKRHGFLATIGHVLAIGATQVLIGLPFLLHHHKSYLKYSFEFSRAFLYKWTVNWRFVSEDTFLSPAWSRALLVGHVTTLLAFGLSKWCRSDGGIWRVLSKGLRRPLRAPLLAPVTADFVATVLFTSNLVGMLFARSLHYQFYSWYALQLPFLAWRTKYPLLVKLILLFSIEYAWNVFPSTTLSSGILCAANSLLVIGVWFGYPEGVSKRDVYKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JHA5</accession>
    <name>A0A2H3JHA5_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">UAA transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WOLCODRAFT_132001</name>
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    <organism evidence="8 9">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD-104</strain>
        </source>
    </reference>
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        <subcellularLocation>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="EmrE-like"/>
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        <property type="entry name" value="SCL35B1-4/HUT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778:SF4">
        <property type="entry name" value="NUCLEOTIDE SUGAR TRANSPORTER SLC35B4"/>
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    </dbReference>
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        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER B"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
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    <keyword evidence="2" id="KW-0813">Transport</keyword>
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    </feature>
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    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="403" mass="43684" checksum="C021FF1A4174BE00" modified="2018-01-31" version="1">MSQSAVNDVLRGVTYACISDWVSILTLIFGGCCSNALTLEQLTSQHPHAGNLLTFCQFLVISLHGLPKFVLLRPYPHLKPRQIPISAYALQVLLFYCLSLLNNAAFAYAIPMAVHIIFRSGGLVVSMILNALLLRRRYNITQIASVVLVTLGVILTTLSASGSKPRSSSSESGTSTARDPLAYATGIAILTAALVLGGFLGIVQDRTYARYTRKSSSTPQGASAGPKDQMHPWQESMFYLHFLSMPLFFLVRGDLVSQFQALSAGPRFEVPVPLPIKQVNWTQSSLLDKMQSADAPSRRLSIPAAYIPLLLNVITQLLCVAGVNRLTARVTSLTVTLILVVRKAVSLMISVLWYNAAGRGLGAVDETKMWAGAFMVFVGTTAYSIGSGQRDTGSPTEKEKKND</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JHE1</accession>
    <name>A0A2H3JHE1_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_53482</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467909">
        <property type="protein sequence ID" value="PCH37138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000218811">
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    </dbReference>
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        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
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        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH37138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="285" mass="31655" checksum="5F97902CD9A56F11" modified="2018-01-31" version="1" fragment="single">MTAKFGLVSAYLATVCLGSVLYGIFLVLAIVSLWLFIRHRKRILKIRRDTGYKCGLLHVDMFIAAVMLELLANTYWISNISRLFQAFVYYEDGSQPLEYYADLSQVFDVVQTGSMVFTLVLTDATIVYRLWVVWDYDKRIIVAPICTLTGLAGKYSIALEVALAQIASGISVFDNSIGHWVTGLCVLTLSTNLYSTSMIVWMVWPITCHASYASKFGGGSLLRLLTMIAESAALYTLWSAIFLIAYLLKSNVQLVANETLSVAAGISFTLMNVRIGIGWEQETDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JHU7</accession>
    <name>A0A2H3JHU7_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_101178</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH41770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JHU7"/>
    <dbReference type="STRING" id="742152.A0A2H3JHU7"/>
    <dbReference type="OMA" id="HTESAFC"/>
    <dbReference type="OrthoDB" id="2501127at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH41770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="179" mass="19597" checksum="92D062295D6A8BD7" modified="2018-01-31" version="1">MRAALLRLSLYIALWLCSALLFVLTIVRLNYTLHLPKGDPLNGGTDFYDPIVVELLVCSLLALGLAPLVLNLLGRYLSNPFTEVSTPVIEVIALGLLWLLWVIGAGVASSIWPSLSFCYNFAACRVLAAMTAFAWLGWLAICGLLVVGMFPFFQKKRDIGATNEVDWVIPTRTAPTAQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
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    <name>A0A2H3JHW4_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
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                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
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                <person name="Young D."/>
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                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH41772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JHW4"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH41772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="149" mass="16725" checksum="CB28AC3E77BFA291" modified="2018-01-31" version="1">MDRAIIPRGKEYEEGTLYNAAMSGLAKEARTALLTLRNSIPDRNSDVAPEILNTMVSRLPLNLPSITHTLQMSTTTFVRAEQRARYSHSKTTSTAVIHPRCRKPGALRGEEIADEVSNEWGKISEDQPLPVCTEQSGQERRRLLPEILR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JI66</accession>
    <name>A0A2H3JI66_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HRQ family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_137476</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
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            <taxon>Phaeolaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH41571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JI66"/>
    <dbReference type="STRING" id="742152.A0A2H3JI66"/>
    <dbReference type="OMA" id="TMGIRNM"/>
    <dbReference type="OrthoDB" id="497541at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021848">
        <property type="entry name" value="HODM_asu-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11927">
        <property type="entry name" value="HODM_asu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH41571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="460" mass="51759" checksum="FE03DAB05E5D22AE" modified="2018-01-31" version="1">MFSPSIADAGLPAVFVLFVVVALVIRQFARSALRPRTDQSNNLGARAPTTAAKAGERQPGEWAPVQFDYPHVDPFIEDISNVKPIPYRPFRWGEYHVTMGIRSMPWDEWIEIDQQFFDYHKVVEHRIRMRGDSTIKVHPAQPGIVGSGQAAAEELVHELAEYLSRRYPSIYQVTRKPLSEKCFPGWYGEGAVKTIGILPLRVTYDLDEQDSMTVASLLVQEDFALMLEGSDGRYYLQAGAICIPGFWRLKDKIGMPLDEIHMTGNVPQYQSKLHLSMGRFFRRLPVDKPVVRNNYGFQVVKPPAAPGADPEAAADPTELAWSRTMHGDEDKADFERSAYIRGTGAPTNELRDAHRGGRVAPLDPATAYLRTERQTLRRLPRTGAIAFTIRVYQTPVVQLAREPGVPGRLASAVRGWSEDVAEYKDLFAYKDVLQYLDQSHNEQVEKGIAVENDRSAAYPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JID0</accession>
    <name>A0A2H3JID0_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Alpha-galactosidase</fullName>
            <ecNumber evidence="9">3.2.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Melibiase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WOLCODRAFT_29139</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the glycosyl hydrolase 27 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.22" evidence="9"/>
    <dbReference type="EMBL" id="KB467931">
        <property type="protein sequence ID" value="PCH37488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JID0"/>
    <dbReference type="STRING" id="742152.A0A2H3JID0"/>
    <dbReference type="OMA" id="FGLYHDI"/>
    <dbReference type="OrthoDB" id="5795902at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14792">
        <property type="entry name" value="GH27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002241">
        <property type="entry name" value="Glyco_hydro_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000111">
        <property type="entry name" value="Glyco_hydro_27/36_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041233">
        <property type="entry name" value="Melibiase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452:SF61">
        <property type="entry name" value="ALPHA-GALACTOSIDASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452">
        <property type="entry name" value="ALPHA-GALACTOSIDASE/ALPHA-N-ACETYLGALACTOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16499">
        <property type="entry name" value="Melibiase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17801">
        <property type="entry name" value="Melibiase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00740">
        <property type="entry name" value="GLHYDRLASE27"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00512">
        <property type="entry name" value="ALPHA_GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 9 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013608230" description="Alpha-galactosidase" evidence="10">
        <location>
            <begin position="22"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha galactosidase C-terminal" evidence="11">
        <location>
            <begin position="327"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PCH37488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="433" mass="47550" checksum="D1FA3C7846DD61A2" modified="2018-01-31" version="1">MIGASTLVLVSSLVVIPVARAIENGVARLPVLGYNTWNTYACNINESIILETASLMKSLGLQDAGYTHVNLDDCWAEKNRSAEGLLVPNQERFPSGFYNLTGQLHDMGFQAGIYGDSGWFTCAGYPGSFEHELTDATTYQDWGFDYLKFDNCAIPFDDIIREGTYGKYQRMADAIATLSQTSGKPPLIFSLCEWGWSQVWLWGQTVGNSWRVDGDIAANWASIASIINLASFITQGTNFYGRNDEDILEVGNGDLTYEENKSHFTAWALLKSPLLIGTDLSAASPGIIEILSNKEILAINQDPVVGTSISPFRWGLNADWTSNSSYPAQYWSGPSENGTVIMLLNTLDEPATMFFNLTESPWIRAGRQYAVRDLWTHTDNGTAVRNFTATDVPAHGVVALLLQDAGNEPAGLYPLCAVWYQCASENGTYVDGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JKC1</accession>
    <name>A0A2H3JKC1_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_152661</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468124">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JKC1"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH42630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="155" mass="17892" checksum="8E8931CDCCF80370" modified="2018-01-31" version="1">MDYLQVVFGIRVRGSVTSFNSIPPHVRPFINFNHTAYIKYYGEDSTRNHISWYPWDKYSQPMQLAELIVLYGDVHWYMEGTSNTPYTPEREESHEDEQTPQVAPLFGTLPALLLVFNPEPFELEELARRPESKYVESVTDLSVTPLTPSPILQAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JLC0</accession>
    <name>A0A2H3JLC0_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_168029</name>
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    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
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        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468020">
        <property type="protein sequence ID" value="PCH39589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JLC0"/>
    <dbReference type="STRING" id="742152.A0A2H3JLC0"/>
    <dbReference type="OMA" id="PDADECY"/>
    <dbReference type="OrthoDB" id="2752444at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH39589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="127" mass="14788" checksum="7DC889C69C0EECFD" modified="2018-01-31" version="1">MNWILYKEQFRAAVLAKGLVRFLEGCDREPRAPEIPGEDSEADEEYESAHNVWIAKHQSIHTLLFWTLPESLKLRIAPLEKASEAWRAVVEEYDDQGKFVQVEILQQMHALRCKENSDPRPTLNQLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JLF9</accession>
    <name>A0A2H3JLF9_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RanBP2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WOLCODRAFT_149495</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH38558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JLF9"/>
    <dbReference type="OrthoDB" id="79830at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.10">
        <property type="entry name" value="Zinc finger, RanBP2-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RanBP2-type" evidence="6">
        <location>
            <begin position="131"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="160"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="246"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="291"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="162"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="180"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="192"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="203"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="246"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PCH38558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="338" mass="35490" checksum="AEAFA823ACB0DE22" modified="2018-01-31" version="1">MVPVSTEEHSANAHAPAKAHLVCQEHPLTPVHAPATLTCDAVTSCTSTSGQQHEQETVMNSKALERAASVLLEALPRYKFSVCVAPSPGAGSRFMKAWQFASSVPVHTLPAYNFMKHVASFLSTSAVSLSKQPEWICGLCQLWSPDSAVKCIVCEAPRPRGPSQASPSPASSSPSSAPSAPEPAPSAPEPTPSALEPASSAPSPTPSAPSPPLPVSGFNWAAAGLAPPSATSDWECSICMVWNKSTGEDQQQRRKSGWLEKSRSTWAPVLGGEEEQPPTVRRDVRLYGEEAQAEGRAQEKQRMAVNSRKASKTAAGTVAYDDGSAGLGIRDAGIKTGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JLN5</accession>
    <name>A0A2H3JLN5_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Double-strand break repair protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">WOLCODRAFT_110082</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Core component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The MRN complex is involved in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR), an error-free mechanism which primarily occurs during S and G2 phases. The complex (1) mediates the end resection of damaged DNA, which generates proper single-stranded DNA, a key initial steps in HR, and is (2) required for the recruitment of other repair factors and efficient activation of ATM and ATR upon DNA damage. Within the MRN complex, MRE11 possesses both single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. MRE11 first endonucleolytically cleaves the 5' strand at DNA DSB ends to prevent non-homologous end joining (NHEJ) and licence HR. It then generates a single-stranded DNA gap via 3' to 5' exonucleolytic degradation, which is required for single-strand invasion and recombination.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 16">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16 18">Belongs to the MRE11/RAD32 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467931">
        <property type="protein sequence ID" value="PCH37554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JLN5"/>
    <dbReference type="STRING" id="742152.A0A2H3JLN5"/>
    <dbReference type="OMA" id="ESCMFNA"/>
    <dbReference type="OrthoDB" id="30417at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030870">
        <property type="term" value="C:Mre11 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008296">
        <property type="term" value="F:3'-5'-DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042138">
        <property type="term" value="P:meiotic DNA double-strand break formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097552">
        <property type="term" value="P:mitochondrial double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00840">
        <property type="entry name" value="MPP_Mre11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000011">
        <property type="entry name" value="Double-strand break repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.110">
        <property type="entry name" value="Mre11, capping domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003701">
        <property type="entry name" value="Mre11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038487">
        <property type="entry name" value="Mre11_capping_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007281">
        <property type="entry name" value="Mre11_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041796">
        <property type="entry name" value="Mre11_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00583">
        <property type="entry name" value="mre11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10139">
        <property type="entry name" value="DOUBLE-STRAND BREAK REPAIR PROTEIN MRE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10139:SF1">
        <property type="entry name" value="DOUBLE-STRAND BREAK REPAIR PROTEIN MRE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04152">
        <property type="entry name" value="Mre11_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000882">
        <property type="entry name" value="DSB_repair_MRE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01347">
        <property type="entry name" value="Mre11_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9 16 18" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 16 18" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 16 18" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11 16 18" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="10 16 18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13 16 18" id="KW-0464">Manganese</keyword>
    <keyword evidence="15 16 18" id="KW-0469">Meiosis</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 16 18" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14 16 18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mre11 DNA-binding" evidence="20">
        <location>
            <begin position="319"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="551"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="592"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="551"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="19">
        <location>
            <begin position="614"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="636"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="670"/>
            <end position="695"/>
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        </citation>
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        </source>
    </evidence>
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        </source>
    </evidence>
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</entry>
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                <person name="Riley R."/>
                <person name="Barry K."/>
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                <person name="Martinez A.T."/>
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                <person name="Spatafora J.W."/>
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                <person name="Benoit I."/>
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                <person name="Ferreira P."/>
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                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
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                <person name="Kumar T.K.A."/>
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                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
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                <person name="St John F."/>
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                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
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                <person name="Wiebenga A."/>
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                <person name="Eastwood D.C."/>
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                <person name="Cullen D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Benoit I."/>
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                <person name="Nagy L.G."/>
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                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
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                <person name="Sabat G."/>
                <person name="Salamov A."/>
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                <person name="Wiebenga A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Barry K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JQ99</accession>
    <name>A0A2H3JQ99_WOLCO</name>
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            <fullName evidence="5">Amino acid transporter transmembrane domain-containing protein</fullName>
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        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
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        <lineage>
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            <taxon>Agaricomycetes</taxon>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">MD-104</strain>
        </source>
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    </feature>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="496" mass="54134" checksum="E0DE08C3C3B3E7C4" modified="2018-01-31" version="1">MPASPRSSSSSESLTSPIHGFDSSAALILVPDDDPASSNSFDFTTDEDTDDDDSHAQPPSVPPLSSITVFVYLLAPLLKLGALLVPRVDFPFKVAIPALLFFAGLSALTRQIWYMLARYVRRADMEEIVLETFARERAKEGRRWLLRQLVRINSGVFRVLLSVMYLRASVDILLPLLPQRILLPSHITTTLVLGVIVLPLYLAPTLAADRVIYATWISVASYFAWLICTAYAHAHGLLVPSATANSLSAFWQGIPTIAFAFTTVSTVPLYAALRGTTQPMPNTRPKRLQSFKLLSLLSVAIAVLCILPLVFFKVSDAPALHEASPLTGGALPILTAAFYAASLTLFIPSILVPTPGLPIPFSVRRIVLLPLSKVLVYCITIGLSLAPSSVTAVLSDIVWVLAFLSTYMLPAFIHIILHNFRRPLSIIIPPNTPVAPSASSTHSDSRNDELLQRKERTLQRRRLGRRLVWDIGVWVLLVPVGGGGLVWAAGRVVGGW</sequence>
</entry>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
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                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
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                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
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                <person name="Ferreira P."/>
                <person name="Findley K."/>
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                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
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                <person name="Lindquist E."/>
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                <person name="Lundell T."/>
                <person name="Martin R."/>
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                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
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                <person name="Stenlid J."/>
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                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
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                <person name="Cullen D."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:inositol phosphoceramide synthase complex"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070917">
        <property type="term" value="F:inositol phosphoceramide synthase regulator activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006673">
        <property type="term" value="P:inositol phosphoceramide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="INOSITOL PHOSPHORYLCERAMIDE SYNTHASE REGULATORY SUBUNIT KEI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28077:SF1">
        <property type="entry name" value="INOSITOL PHOSPHORYLCERAMIDE SYNTHASE REGULATORY SUBUNIT KEI1"/>
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    </dbReference>
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    </dbReference>
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            <end position="47"/>
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        </location>
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            <end position="211"/>
        </location>
    </feature>
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            <end position="274"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="307" mass="33817" checksum="D687F3E6EC7FD977" modified="2018-01-31" version="1">MKLTLRPEWRLRPLSSALGFLDLKTAVTIVLLFAVLNKVAGVYGLIATFTGAGGSVAQLSLYIYSCVALAALVWGLRATSQENPKHTLYFAHLFFADHVLSTAWLVFFAVVWWVYTPHDGRRQANSAAQEEMMNAGTQLGGHNMTAEERERAAMTIWSEEKGLATAVIVLGWLVKFYFAALLYSYAIHLRKGSYRSLPRSRTSPTLGSTSLGVLPDEEDEDVEDFYRLPVRAPPQAQSHSRQPSPGRARRKPVLSASKGDADEVDEVLFDEDELSAGGHLRAGTSTESTSGDDEELGRSTSHSRRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="3 4" key="1">
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            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
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                <person name="Yadav J.S."/>
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                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468053">
        <property type="protein sequence ID" value="PCH40078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JQP5"/>
    <dbReference type="OMA" id="IAMPNPH"/>
    <dbReference type="OrthoDB" id="3256943at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="134"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH40078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="276" mass="29309" checksum="A05208C91FA4BCE1" modified="2018-01-31" version="1">MSSSPTPTTPATGTPPTLSSTASETASATTSNANSGSHTTPSSLYLFTFLATLFLLLFVSGAIVLRSFILRRRFRRRIEEAIAAGVVLAPQNAGSSRSYRKLEKPELWDALLAPAADDAWRSIMPVAAKTSFLPSPGAGSGSPDPASTASPLQSATTPSRSLLRPFVRRRTTAPPSQPLTPVPTSPQPQSESVPMDLMATSSAVQVTVLIQMPNPHRPARTMDITEQMTSSLKGKKRSSYWEDEEEEEGVPDVVLGVAQASCNGPISSATGRRESQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JQV2</accession>
    <name>A0A2H3JQV2_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WOLCODRAFT_26824</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
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        <property type="protein sequence ID" value="PCH44516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OMA" id="ATEFMIW"/>
    <dbReference type="OrthoDB" id="2213137at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF287">
        <property type="entry name" value="MFS MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
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            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
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            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
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            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
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            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="351"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="386"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="434"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PCH44516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="460" mass="49545" checksum="40E9B70DE619E5A7" modified="2018-01-31" version="1">MESFELAEVCADSPEEIRTVTTNTPISEPAHDSEANVQELPAIDGGWRAWRFCASAFAIEVIIWGFEFSYGIFQDYYTSNAPFQNVSPVTVAAVGTSALAIQYGEALFLSLFFERYPDLLAASAWLGLGVVAVSLLLASFASKVWQLVMLQGVGFGIGGGLMYFPIVALLPQWFSQRRGLATGIIFSGSGLGGFAFPYILEAMLTRLGFRWTLRIWCIATSILGGISLLGMKPRLPVPKFQRGQTRPRFIPPQLHFIKTPHFWALSIATGLQALSYYSVSLYISTFTKAISTPLYASIVLSLFNSSGVVCQIIMGLLCDRLPYAWIMSVSALGGGLAAFLLWGFAHTLPLVIAFAIVFGGLMGGFNSVGPAAAADCAGSKPEQSSLIWACSWVLKGVAVVIGPIISGVLYDTGRSALHTNELRYGAFGFKNFEIFVGTCAVATSLASIVVAATRNRVVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JRJ2</accession>
    <name>A0A2H3JRJ2_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zinc/iron permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WOLCODRAFT_154152</name>
    </gene>
    <organism evidence="7 8">
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        <name type="common">Brown rot fungus</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB468157">
        <property type="protein sequence ID" value="PCH44115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OMA" id="YIAICFH"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF32">
        <property type="entry name" value="ZINC-REGULATED TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PCH44115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="218" mass="23013" checksum="7F10A80A45420A25" modified="2018-01-31" version="1">MRMRPDVAEGHGHGEYAPEPIHDKIVPSNDAGSDIGLTKERSSDDLEAAPKHEHGAIGGVSDSAVAQIIGVAILEFSVLLHSVLIGLTLAADPSFKVLFVVIIFHQMFNSLGVGSRLAYMELPRAYTHVPTIGAGLYWCTTPAGIAAGFGARTTYNPNGATASIVSGVLDAFSSGILIYTGLVELMAHVFIFNRAMIEESSNCMMLGAGLMALLGKWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JSW1</accession>
    <name>A0A2H3JSW1_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_78117</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468168">
        <property type="protein sequence ID" value="PCH45051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JSW1"/>
    <dbReference type="STRING" id="742152.A0A2H3JSW1"/>
    <dbReference type="OMA" id="THARCIW"/>
    <dbReference type="OrthoDB" id="2782214at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="73"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH45051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="106" mass="12198" checksum="3B5079BA86ECE9E0" modified="2018-01-31" version="1" fragment="single">CLWDGGSCGILLDDTSAAGVNRHLKEFHFCNQEKPWDNRSRGICHWEVNCGREMYYESFGKHVAAVHLRCTVRECEQCHREFARPDTLRRHVASTCSGQSEKTNRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JTF4</accession>
    <name>A0A2H3JTF4_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_78317</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468168">
        <property type="protein sequence ID" value="PCH44835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JTF4"/>
    <dbReference type="STRING" id="742152.A0A2H3JTF4"/>
    <dbReference type="OMA" id="YWAVRSA"/>
    <dbReference type="OrthoDB" id="498125at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF121">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH44835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="269" mass="28336" checksum="871CB76724D4A777" modified="2018-01-31" version="1">MSALSNLRRTAIVTGAAKGIGRAIAFRLADDGLQVAVNDKRSERAPLLEMVAEIESKGGQAMAMTADVSIEEEVRAMTAEVARQLGGLDVMVANAGVAGPLTPLVDCPVQGWEEIMAVNLRGVMLSYKHAAIQMIKQGRGGRIIGASSILGKQGRISAAPYSTTNFAVRGLTHSTARELARYNITVNAYAPGIILTTLATSVHDLHNGGPGSTIKKTFGLPLNTPNAEPEVVASLVSYLAKPEAHFITGNSAEWLVAAYILSSELCQVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JTZ8</accession>
    <name>A0A2H3JTZ8_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_17679</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468124">
        <property type="protein sequence ID" value="PCH42379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JTZ8"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH42379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="455" mass="50832" checksum="1DE5887F736B7F13" modified="2018-01-31" version="1">MVKPSSFLPKGARQPASGDKPSKLPACRIPRRVGLSTPVKGGAIAQPRPRCTRAGFEDILYKHWDVKGDLNREHIMVCQVEDQHDSSDMYGDGKSDDEQNDKACATSKTILSRRQRSNSDSSTESSELQAQTPCSVEDAIWADSAAIKSVDALVGRVATTKAEEIVDTRKEHGPVRQLAQWMQTPGTDGHVIQSERTDAHTRLLDSVLAEVALSQDVDTKAKAYSRLLDDLVADIEVALKIGTGHLKTKAHADLLETVIVEIEVTQYAASTLDVINAIVVEPFSEGVDVSKTTDVHWHLNVAQDENLLKYAVTDEHSSGPMADRWALDTEGDEYLNQNRRPLVRRVEDDKDPWATRWILDTRGDELLSGRNVRTDEQVSNECWASRWTLDTAGDEHVGRRPIVRAVECEEDRWATRWFLPRTEDDEVIPKDVAKLRSMAIRNCVRLGVPICFYAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JV94</accession>
    <name>A0A2H3JV94_WOLCO</name>
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        <recommendedName>
            <fullName evidence="5">Helicase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WOLCODRAFT_86118</name>
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    <organism evidence="6 7">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD-104</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
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    </dbReference>
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        <location>
            <begin position="133"/>
            <end position="159"/>
        </location>
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        <location>
            <begin position="64"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PCH40634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="222" mass="25036" checksum="53788504732BF5AD" modified="2018-01-31" version="1" fragment="single">NFYLNIRKSLTHPACHSSVDFLKGNLSISSKIDGLIKILKHHLAMDNMSPMKYDSNEKDLVPNNKKTVLDRAPESEPDKIIIYITFPSNLPTLTEFLEAEGIKFFTYTGSNLMKIHSDTLKAFHKAGCDDPRVLIMLGAGAVGLNIAFMNILIIMNILWSVQEDAQLIGRVWRHPQPKLVEVYRLIAAGIPDMFLNNISFNKGYMHRSFANASKTLRKPPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JVJ0</accession>
    <name>A0A2H3JVJ0_WOLCO</name>
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            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
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                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468157">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JVJ0"/>
    <dbReference type="STRING" id="742152.A0A2H3JVJ0"/>
    <dbReference type="OMA" id="NIWISGA"/>
    <dbReference type="OrthoDB" id="2667387at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH44003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="611" mass="68198" checksum="0F14B42EA03946E8" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JWH4</accession>
    <name>A0A2H3JWH4_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_162792</name>
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    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Phaeolaceae</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
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                <person name="Lundell T."/>
                <person name="Martin R."/>
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                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
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                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH41074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JWH4"/>
    <dbReference type="OMA" id="IMMAWAF"/>
    <dbReference type="OrthoDB" id="514070at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="360"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH41074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="419" mass="44864" checksum="EEA82BC1573E5CFB" modified="2018-01-31" version="1">MSAAETKLALPAFLKVLTSNNVPPSKAIAVAGKIYKTHGTPSLLAQLTDAKLRAAGVDDKELRKLVLAAIRKAGFKSTGQASSALSGAQNSTPGGAGPSSQPSAERPSQRRKRKRDDERNEFLPDRPSDEEEGAQYSSLEFNEILDEQVLSTKFAVVNRAPIMMAWAFVVSERLGFQREEALSIASVYTEMNAITKGVSLGIFDKHKGRGMEASVNGSQPYVDLMGRRPLYRTASGSWRALSAGSPAPPSAAYAYIARALRQTARSVLGALRLLAASYAPAELARRGFALYAEFRPDVRGWGERGELRCAAILALRGAVQGKSESGEGAARPEIKVEYREADGEGGAGAPVQQRQVVKEGTEGGDGGVVDTRGAQAQKSPELQEPPEKKQRGMTLEEYEAALDADPTFDGIDLNFDIVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JWQ1</accession>
    <name>A0A2H3JWQ1_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">WOLCODRAFT_74197</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">MD-104</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468135">
        <property type="protein sequence ID" value="PCH43329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JWQ1"/>
    <dbReference type="STRING" id="742152.A0A2H3JWQ1"/>
    <dbReference type="OMA" id="ACKEAMR"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="447"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PCH43329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="521" mass="59848" checksum="71D15D7BC7D8886A" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JYW7</accession>
    <name>A0A2H3JYW7_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Complex 1 LYR protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WOLCODRAFT_153138</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I LYR family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468135">
        <property type="protein sequence ID" value="PCH43078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JYW7"/>
    <dbReference type="STRING" id="742152.A0A2H3JYW7"/>
    <dbReference type="OMA" id="EICTLYA"/>
    <dbReference type="OrthoDB" id="14535at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20266">
        <property type="entry name" value="Complex1_LYR_NDUFA6_LYRM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045299">
        <property type="entry name" value="Complex1_LYR_NDUFA6_LYRM6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016488">
        <property type="entry name" value="NADH_Ub_cplx-1_asu_su-6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12964:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12964">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE B14 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006643">
        <property type="entry name" value="NDUA6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="9">
        <location>
            <begin position="23"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PCH43078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="131" mass="15449" checksum="D123936998748A11" modified="2018-01-31" version="1">MNTIPARLARAAQISASPEQARQRVFQLYRDWYRAAPEIISLYALPVSVPFFRHAIRRKFEENRYVTDQRVIDVLLLKGRQEYQETMNQWKMYDHVMGILLESRKGRPRSFLEKFYEGRDEDAVLPAATGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JZK8</accession>
    <name>A0A2H3JZK8_WOLCO</name>
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        <recommendedName>
            <fullName evidence="7">Regulator of G protein signaling superfamily</fullName>
        </recommendedName>
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    <gene>
        <name evidence="5" type="ORF">WOLCODRAFT_137487</name>
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    <organism evidence="5 6">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH41597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JZK8"/>
    <dbReference type="STRING" id="742152.A0A2H3JZK8"/>
    <dbReference type="OMA" id="DPGMRYL"/>
    <dbReference type="OrthoDB" id="196547at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:negative regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04450">
        <property type="entry name" value="DEP_RGS7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08708">
        <property type="entry name" value="RGS_FLBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058855">
        <property type="entry name" value="RGS1/SST2-like_Fungal-DR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845:SF192">
        <property type="entry name" value="DOUBLE HIT, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845">
        <property type="entry name" value="REGULATOR OF G PROTEIN SIGNALING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25889">
        <property type="entry name" value="WHD_Fungal_DR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00049">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50186">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0734">Signal transduction inhibitor</keyword>
    <feature type="domain" description="DEP" evidence="4">
        <location>
            <begin position="242"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="3">
        <location>
            <begin position="406"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="334"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PCH41597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="640" mass="71071" checksum="220BC57FE7A6DB3B" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K064</accession>
    <name>A0A2H3K064_WOLCO</name>
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        <recommendedName>
            <fullName evidence="3">DUF155 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WOLCODRAFT_132359</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RMD1/sif2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468124">
        <property type="protein sequence ID" value="PCH42394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K064"/>
    <dbReference type="OMA" id="QLMKFRQ"/>
    <dbReference type="OrthoDB" id="242766at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070131">
        <property type="term" value="P:positive regulation of mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003734">
        <property type="entry name" value="DUF155"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051624">
        <property type="entry name" value="RMD1/Sad1-interacting"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255">
        <property type="entry name" value="REQUIRED FOR MEIOTIC NUCLEAR DIVISION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255:SF1">
        <property type="entry name" value="REQUIRED FOR MEIOTIC NUCLEAR DIVISION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02582">
        <property type="entry name" value="DUF155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF155" evidence="3">
        <location>
            <begin position="118"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="22"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008306"/>
        </source>
    </evidence>
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            <dbReference type="Pfam" id="PF02582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PCH42394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K076</accession>
    <name>A0A2H3K076_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Dbl homology domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WOLCODRAFT_90903</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD-104</strain>
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        <property type="match status" value="2"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="241"/>
            <end position="425"/>
        </location>
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        </location>
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        <location>
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        <location>
            <begin position="882"/>
            <end position="1190"/>
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        </location>
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            <begin position="1"/>
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            <begin position="56"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH44559.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="1281" mass="145966" checksum="E077011CD0AD7DF7" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K0B5</accession>
    <name>A0A2H3K0B5_WOLCO</name>
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        <submittedName>
            <fullName evidence="4">Aryl-alcohol dehydrogenase</fullName>
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    <gene>
        <name evidence="4" type="ORF">WOLCODRAFT_102161</name>
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        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Phaeolaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.</text>
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    </dbReference>
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    </dbReference>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K1S4</accession>
    <name>A0A2H3K1S4_WOLCO</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="2" type="ORF">WOLCODRAFT_154118</name>
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    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
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        <lineage>
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            <taxon>Phaeolaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="60"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH44078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="142" mass="16155" checksum="FC1F0C69A27822AB" modified="2018-01-31" version="1">MAPIAQDFGHIEGKARLDSIVSCLANNFVLINGCRGRMSSSIEWHHPWPPQAPVDRPRAFRSSESASSRINFSRGGKAKWNRKEQRQRKSHPGSQSFVLSTGYTLPAERPIWYSRLPTDWFKDAGASSLERRMGSLRWDVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K208</accession>
    <name>A0A2H3K208_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_153131</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468135">
        <property type="protein sequence ID" value="PCH43074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K208"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH43074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="117" mass="13109" checksum="5C414ED9F00F2F70" modified="2018-01-31" version="1">MDTLRWNDTTINLKSGATRPTKPLTTSRVPPDRLGTHLGPTVQRRYVDHDSLRSLTSAPSDWLGGPYGSEEGSELRWAGRLTGKIPAYMEGFQRTTEGFQRTVRGTNLWCDGTKSRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K4H1</accession>
    <name>A0A2H3K4H1_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Formate/nitrite transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WOLCODRAFT_138692</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the FNT transporter (TC 1.A.16) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468146">
        <property type="protein sequence ID" value="PCH43954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K4H1"/>
    <dbReference type="STRING" id="742152.A0A2H3K4H1"/>
    <dbReference type="OMA" id="MIWFPIM"/>
    <dbReference type="OrthoDB" id="4829at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015513">
        <property type="term" value="F:high-affinity secondary active nitrite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015707">
        <property type="term" value="P:nitrite transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1080.10:FF:000011">
        <property type="entry name" value="Formate family transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000292">
        <property type="entry name" value="For/NO2_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024002">
        <property type="entry name" value="For/NO2_transpt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30520">
        <property type="entry name" value="FORMATE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30520:SF6">
        <property type="entry name" value="FORMATE_NITRATE FAMILY TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01226">
        <property type="entry name" value="Form_Nir_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01006">
        <property type="entry name" value="FORMATE_NITRITE_TP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="199"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="241"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="280"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PCH43954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="310" mass="33284" checksum="F797236055F31F58" modified="2018-01-31" version="1">MANFDPPSTLKPAQVAVAMVEHGIVKHRTRADLVFFKAVLAGVMLSFGGLLSEIISGGSAGINANNPGLVKVLGGAVFPVGLIMIVLQGQELLTSNMMIFPMACLKGAVPWWGLPWNWFLVTFGNLSGSLFFAAVLTKYSGIISTEPYISYAQDFALHKAKEPEWYQIFLRGIGCNWLVCVAVWQAAGARDTLSKIVAVWIPIMIFVSAGFDHVIANMFSVPLGIMFGADLTVAEYIRKSLIASYLGDIVGALIVALPATYFYLGDYNASGLRGVEEGEGFNDARDTSSSTASGNGKEREVAFENAPRVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K6J4</accession>
    <name>A0A2H3K6J4_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Histone deacetylase interacting domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WOLCODRAFT_123950</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB468168">
        <property type="protein sequence ID" value="PCH44684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K6J4"/>
    <dbReference type="STRING" id="742152.A0A2H3K6J4"/>
    <dbReference type="OMA" id="MCEEVIK"/>
    <dbReference type="OrthoDB" id="10265969at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070822">
        <property type="term" value="C:Sin3-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1160.11:FF:000001">
        <property type="entry name" value="Paired amphipathic helix protein Sin3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1160.11:FF:000002">
        <property type="entry name" value="Paired amphipathic helix protein SIN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1160.11">
        <property type="entry name" value="Paired amphipathic helix"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013194">
        <property type="entry name" value="HDAC_interact_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003822">
        <property type="entry name" value="PAH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036600">
        <property type="entry name" value="PAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039774">
        <property type="entry name" value="Sin3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031693">
        <property type="entry name" value="Sin3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12346:SF0">
        <property type="entry name" value="SIN3A, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12346">
        <property type="entry name" value="SIN3B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02671">
        <property type="entry name" value="PAH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08295">
        <property type="entry name" value="Sin3_corepress"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16879">
        <property type="entry name" value="Sin3a_C"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PAH2 domain"/>
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        <property type="entry name" value="PAH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase interacting" evidence="9">
        <location>
            <begin position="448"/>
            <end position="547"/>
        </location>
    </feature>
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        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
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        <location>
            <begin position="221"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
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            <begin position="747"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1170"/>
            <end position="1214"/>
        </location>
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        <location>
            <begin position="91"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="333"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
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            <end position="786"/>
        </location>
    </feature>
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        <location>
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        </location>
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        </location>
    </feature>
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        <location>
            <begin position="1186"/>
            <end position="1198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PCH44684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="1214" mass="136584" checksum="8005920769BA17D4" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K7J2</accession>
    <name>A0A2H3K7J2_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WOLCODRAFT_106017</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
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        </reaction>
    </comment>
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        <property type="protein sequence ID" value="PCH45044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OMA" id="NEYETCP"/>
    <dbReference type="OrthoDB" id="9977870at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22584">
        <property type="entry name" value="Rcat_RBR_unk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="139"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="357"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="359"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH45044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="399" mass="45022" checksum="A9C4BFF4592BFE55" modified="2018-01-31" version="1">MLAVPDRTGDRALYSIVKELDDLKNLRPQRGGHGDPRRMSRKWREHSYEEPVALATLPKHNEEQYERRVSIIYVPPLCEIPATPAMRKSLLRPISLSVRSVSYTNKLRRKFSSASGTSLSRRSTTGSSNRFGIPKVLKRTRTCVVCQSAIDGTRVRVPCGHYLDIPCFMHLVDKSAHDESLFPPSCCRQAIPDRTLRHYLPPPLIEVLADKGREFSATKRVYCSNPPCSRFLGPRTEDSPPQVLTCTACTTQTCSACRERMRAHKPHRCGRDRAQRELLALANQKGWARCPACEHMIELRSGCYHMTCICATQFCYLCRSPWKTCDCPQWEVMQLRDVGEGLSLDRPLSGLRVALRTETAAKKPESKADRPKRSGQTVARPISRVQSEVSVAASKPFQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K7N7</accession>
    <name>A0A2H3K7N7_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein HGH1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WOLCODRAFT_133251</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HGH1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468157">
        <property type="protein sequence ID" value="PCH44447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K7N7"/>
    <dbReference type="STRING" id="742152.A0A2H3K7N7"/>
    <dbReference type="OMA" id="MCILLTN"/>
    <dbReference type="OrthoDB" id="338814at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039717">
        <property type="entry name" value="Hgh1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007206">
        <property type="entry name" value="Protein_HGH1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007205">
        <property type="entry name" value="Protein_HGH1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13387">
        <property type="entry name" value="PROTEIN HGH1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13387:SF9">
        <property type="entry name" value="PROTEIN HGH1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04063">
        <property type="entry name" value="DUF383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04064">
        <property type="entry name" value="DUF384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein HGH1 N-terminal" evidence="4">
        <location>
            <begin position="106"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="Protein HGH1 C-terminal" evidence="5">
        <location>
            <begin position="351"/>
            <end position="404"/>
        </location>
    </feature>
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        <location>
            <begin position="399"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="425"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006712"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00014076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF04063"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF04064"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH44447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="436" mass="47912" checksum="DB6421560F182067" modified="2018-01-31" version="1">MSAEQLKELAPFLHDANPQVRQIALANLLGHTPKGSPLRDIFFDGLRSGGLQKQEDSGIVRDLKLLCRDQLATAHDAFRALVNLSDYSLIVGTLSEPSFLSFLVSYILNPQAILADLASMLLSNLTASSSTCSTLLTLNIPILPDAKSPTSYFPVQSQSGTCPAPVPYPSGEPRNVNALPLLVDAFVQGASVEETQDKEKRPRKSSLHFLASVFANLSTTPAGRLFFLTPRPADPLQSDGDAEYPLTKLLVFTEHKDTIRRGGVASTLKNCAFHTPSHRALLSSDSIRIAVPPSTAEAPGMDILPYLLLPLAGSEEFDLEDQELLPSALQFLPPTKTREPDPVLRLTHVETLLLLCTTRWARDYLRQNGVYEIVRALHENEQVDKISEHVERLVNFLKREEGPETAADDDSSVNEAPLESKVEEMSDDEDSKIEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K9S1</accession>
    <name>A0A2H3K9S1_WOLCO</name>
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        <recommendedName>
            <fullName evidence="3">DUF6535 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WOLCODRAFT_145352</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468168">
        <property type="protein sequence ID" value="PCH45147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K9S1"/>
    <dbReference type="OrthoDB" id="3219854at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045338">
        <property type="entry name" value="DUF6535"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20153">
        <property type="entry name" value="DUF6535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="257"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6535" evidence="3">
        <location>
            <begin position="145"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="595"/>
            <end position="629"/>
        </location>
    </feature>
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        <location>
            <begin position="17"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PCH45147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="629" mass="70263" checksum="52F5E6F95BDDA415" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3ITL0</accession>
    <name>A0A2H3ITL0_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Iron-sulfur assembly protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WOLCODRAFT_63340</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Agaricomycetes</taxon>
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            <taxon>Phaeolaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in the assembly of mitochondrial and cytoplasmic iron-sulfur proteins. Probably involved in the binding of an intermediate of Fe/S cluster assembly.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the HesB/IscA family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH33041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="742152.A0A2H3ITL0"/>
    <dbReference type="OMA" id="LYIYGMQ"/>
    <dbReference type="OrthoDB" id="333486at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.300.12:FF:000001">
        <property type="entry name" value="Iron-binding protein IscA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.300.12">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016092">
        <property type="entry name" value="ATAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000361">
        <property type="entry name" value="ATAP_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050322">
        <property type="entry name" value="Fe-S_cluster_asmbl/transfer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017870">
        <property type="entry name" value="FeS_cluster_insertion_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035903">
        <property type="entry name" value="HesB-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00049">
        <property type="entry name" value="iron-sulfur cluster assembly accessory protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10072:SF41">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY 1 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10072">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01521">
        <property type="entry name" value="Fe-S_biosyn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89360">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01152">
        <property type="entry name" value="HESB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core" evidence="4">
        <location>
            <begin position="11"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00054873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00071673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PCH33041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="117" mass="12498" checksum="A773FEFE892527A9" modified="2018-01-31" version="1" fragment="single">PARTHADPPQTPAAVQRLRALLGGPTPQLIRIGVRNKGCAGLSYNLEYVDAPGRFDEVVEQDGVRVLIDSKALFSIIGSEMDWHEDALSAKFAFKNPNIKDACGCGESFTVGSSTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IUF6</accession>
    <name>A0A2H3IUF6_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CBS-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WOLCODRAFT_63134</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
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                <person name="Cullen D."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7 8">MD-104</strain>
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</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IVF6</accession>
    <name>A0A2H3IVF6_WOLCO</name>
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        <submittedName>
            <fullName evidence="5">Nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="5" type="ORF">WOLCODRAFT_61655</name>
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    <organism evidence="5 6">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1221748"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD-104</strain>
        </source>
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    </dbReference>
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        <property type="entry name" value="ATP-DEPENDENT HELICASE IRC3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TYPE I RESTRICTION ENZYME ECOKI R PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="44"/>
            <end position="220"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        </location>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH33701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="670" mass="74286" checksum="A9D1F427EB2053D3" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IVH1</accession>
    <name>A0A2H3IVH1_WOLCO</name>
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        <recommendedName>
            <fullName evidence="1">protein-ribulosamine 3-kinase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WOLCODRAFT_112912</name>
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        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>N(6)-D-ribulosyl-L-lysyl-[protein] + ATP = N(6)-(3-O-phospho-D-ribulosyl)-L-lysyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48432"/>
            <dbReference type="Rhea" id="RHEA-COMP:12103"/>
            <dbReference type="Rhea" id="RHEA-COMP:12104"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:90418"/>
            <dbReference type="ChEBI" id="CHEBI:90420"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.172"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="2">
            <dbReference type="Rhea" id="RHEA:48433"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the fructosamine kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.172" evidence="1"/>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH33990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3IVH1"/>
    <dbReference type="STRING" id="742152.A0A2H3IVH1"/>
    <dbReference type="OMA" id="RECDIAM"/>
    <dbReference type="OrthoDB" id="5772781at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102193">
        <property type="term" value="F:protein-ribulosamine 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016477">
        <property type="entry name" value="Fructo-/Ketosamine-3-kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12149">
        <property type="entry name" value="FRUCTOSAMINE 3 KINASE-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12149:SF8">
        <property type="entry name" value="PROTEIN-RIBULOSAMINE 3-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03881">
        <property type="entry name" value="Fructosamin_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006221">
        <property type="entry name" value="Ketosamine-3-kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00048655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR006221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PCH33990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="304" mass="33346" checksum="FC77082A89110438" modified="2018-01-31" version="1">MPSNIHCVFVQSIQKEEPGATLTASSSPPIKSSSGAGYIGKIGSASEKEQYVGEAESLKALNIAAPGLAPRLIAYGVIDEETAESPSDVGKPYFLSEYVDMGSLTDGTAKVLGKRLAAEVHTYKSTKGFGFEVPTFCGATRQDNGWYETWEQCYDALIEGLLDKLNAQGGYESLCKQGQEIRERVIPALLRPLVIQPVLLHGDLWSGNTGTDRKTGQPIIFDPSSYFGHNEADLAIARIFGGIPPSFFKTYHEHLPKSEPEDQYELRSDLYELYHYLNHTVLFGGSYASSARRKMDRLLKAIPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IYE7</accession>
    <name>A0A2H3IYE7_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_165939</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467843">
        <property type="protein sequence ID" value="PCH34986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3IYE7"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH34986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="156" mass="17321" checksum="0DBFF4DB02FD121F" modified="2018-01-31" version="1" fragment="single">KCRSSLESTSSRICTTISFSGCRTASSEPRSSSPRLGPPRVLRTSWWNVIRHENGSYVIQHNATGLYASSLYDVFGQAVVAAPTEQFFALRQVGIDQNILNIGTSSGEIYWNEQDTLAGAPVWQYTVVVSGFDNSTESLDTNPHRQWNFTRIADLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-05-03" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IYZ0</accession>
    <name>A0A2H3IYZ0_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_155885</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467843">
        <property type="protein sequence ID" value="PCH35212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3IYZ0"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH35212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="96" mass="10500" checksum="7C31F7F75FCC4CBD" modified="2018-01-31" version="1">MLGFDGTIQACKDFRRCIVKVLLCCTLTRLYYSVAIAVVQARSKREVTVVTCALGELVRAPGDSWETGLEEANTVLPKARDVHRSTLKRATSIATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IZ21</accession>
    <name>A0A2H3IZ21_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">NCS1 nucleoside transporter family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WOLCODRAFT_107111</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467843">
        <property type="protein sequence ID" value="PCH35196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3IZ21"/>
    <dbReference type="OMA" id="GWNWRAV"/>
    <dbReference type="OrthoDB" id="2018619at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11482">
        <property type="entry name" value="SLC-NCS1sbd_NRT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4160.10:FF:000001">
        <property type="entry name" value="Uracil permease, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012681">
        <property type="entry name" value="NCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045225">
        <property type="entry name" value="Uracil/uridine/allantoin_perm"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00800">
        <property type="entry name" value="ncs1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618:SF2">
        <property type="entry name" value="ALLANTOIN PERMEASE-RELATED"/>
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        <property type="entry name" value="DUF6698"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20414">
        <property type="entry name" value="DUF6698"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="444"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="478"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH35862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="569" mass="64379" checksum="606FEEC692F8105B" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J3H5</accession>
    <name>A0A2H3J3H5_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_140592</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467898">
        <property type="protein sequence ID" value="PCH36800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J3H5"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH36800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="127" mass="14014" checksum="4ABB2DA6B4A5BCD2" modified="2018-01-31" version="1" fragment="single">MSRSKSCRAEATSNLTGTAIVGIDSRIRGVLHDQTTIHGATPPDAVGCSIRPPSDPEARPPLVTCEDPVIPLRTGQARTVVKQQPKEPEMKRRWHPAYCVVHTLYSKKRPFLRACCGLDDKSSPYCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J3R3</accession>
    <name>A0A2H3J3R3_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aryl-alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WOLCODRAFT_140625</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB467898">
        <property type="protein sequence ID" value="PCH36882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J3R3"/>
    <dbReference type="STRING" id="742152.A0A2H3J3R3"/>
    <dbReference type="OMA" id="GWTEPPI"/>
    <dbReference type="OrthoDB" id="48988at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19146">
        <property type="entry name" value="AKR_AKR9A1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF2">
        <property type="entry name" value="ARYL-ALCOHOL DEHYDROGENASE AAD10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="3">
        <location>
            <begin position="37"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PCH36882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="389" mass="43477" checksum="CFA4C6A83D3CBAE7" modified="2018-01-31" version="1">MAQASRISKFWTPAPEPSTKLGRHRQLAPLAGVHVSPICLGAMSIGDQWGPFGMGQMDKESSFKLLDAFYEAGGNFIDTASNYQDETSEMFVGEWMEARGVRDQMVVATKYTTNFKRAANIPQKTSYVGNNMKSLHISVEASLKKLRTDYIDILYVHWWDWHTSVEEVMNGLHHLVAQGKVLYLGISDTPAWIVAKANTYARMAGKTPFVIYQGAWSILQRDFEREIIPMALTEGMALAPWNVLASGRIRTDAEEERRRQTGEKGRTIASDQWERTPDQRKVCQALEKVAADVGARSITSVAIAYVMQKTPYVFPIVGGRKVEHLMDNIDALNVALSPEQIAFLESVLPFDVGFPQSMIGDGSDYNPIFKSAGNFDIWPAPQPIRPRQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J3X8</accession>
    <name>A0A2H3J3X8_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WOLCODRAFT_87505</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH34483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J3X8"/>
    <dbReference type="STRING" id="742152.A0A2H3J3X8"/>
    <dbReference type="OMA" id="CHEYELE"/>
    <dbReference type="OrthoDB" id="27652at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02663">
        <property type="entry name" value="Peptidase_C19G"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
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        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF733">
        <property type="entry name" value="RE52890P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="7">
        <location>
            <begin position="34"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="69"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="207"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="480"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="106"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="208"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="556"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="585"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="598"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="643"/>
            <end position="657"/>
        </location>
    </feature>
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        <location>
            <begin position="662"/>
            <end position="674"/>
        </location>
    </feature>
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        </location>
    </feature>
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            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
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            <end position="808"/>
        </location>
    </feature>
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        <location>
            <begin position="863"/>
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        </location>
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        <location>
            <begin position="909"/>
            <end position="923"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PCH34483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="934" mass="98643" checksum="723066A9683A3E31" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J464</accession>
    <name>A0A2H3J464_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ferritin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_134335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467898">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Rds1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR38705:SF5">
        <property type="entry name" value="RESPONSE PROTEIN RDS1, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G12490)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Ferritin-like"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013789804" description="Ferritin-like domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH36761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="296" mass="31469" checksum="8A199C052F84F28B" modified="2018-01-31" version="1">MYTQLLLALAGASAVIAAPAQSAPSITQVLQYALSLEYLENSFYTGALEKYDTQAFIDSGFPDWVRGRFEQISENEQTHVKFLQGALGASAPQPCNYSFPYTDPKSFVTLSMGIEGVGAAAYLGASKYITDPGTLLAAASILSVEQRQVGWVSSAVLKHQPWDGAFQTPLTINGAYSLAMQFITSCPSSNPPLPVTTFPALTVSETSPQPGSTITISFNNANNVSPTYLAWFNGLEVVFTNIDTNGAAQVPSGLHGTVYVGVVSSDQTPLSDADMVSGLAIMQFPYDSMASETDNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J4Q3</accession>
    <name>A0A2H3J4Q3_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aminopeptidase P N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WOLCODRAFT_139563</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD-104</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peptidase M24B family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467832">
        <property type="protein sequence ID" value="PCH34763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="742152.A0A2H3J4Q3"/>
    <dbReference type="OMA" id="DAHALFF"/>
    <dbReference type="OrthoDB" id="10261878at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01087">
        <property type="entry name" value="Prolidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007865">
        <property type="entry name" value="Aminopep_P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001131">
        <property type="entry name" value="Peptidase_M24B_aminopep-P_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052433">
        <property type="entry name" value="X-Pro_dipept-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226:SF1">
        <property type="entry name" value="XAA-PRO DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05195">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01011">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00491">
        <property type="entry name" value="PROLINE_PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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        <location>
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                <person name="Barry K."/>
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                <person name="Martinez A.T."/>
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                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
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                <person name="Hori C."/>
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                <person name="Kallen N."/>
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        </source>
    </evidence>
    <sequence length="209" mass="23399" checksum="FC1D02F028456058" modified="2018-01-31" version="1" fragment="single">FREWSQLELNSGVVNLSPGWHHQGHEGLDDPIHISASLRDKNKQAGDEWLHDIQESSAILSGMMAVMHPDLHAAGQECMRRLAQNEDLKDTLQRWASIFNGAQIISNRVTPAHRDSKSRMQWYDLLASIGSYHNVSLDLHGANISIKDGPGTVIALCGTAVRHSLMKYEGDRLCYAYFMRDSVHASMHVEAAGWCKTDHMEALLMLQGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J641</accession>
    <name>A0A2H3J641_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WOLCODRAFT_64699</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH37676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J641"/>
    <dbReference type="STRING" id="742152.A0A2H3J641"/>
    <dbReference type="OMA" id="TMIMTEP"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000297">
        <property type="term" value="F:spermine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF132">
        <property type="entry name" value="POLYAMINE TRANSPORTER 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="282"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="361"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="401"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="459"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="53"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PCH37676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="494" mass="54019" checksum="2FA013E4A1B4A49D" modified="2018-01-31" version="1">MALRPIPTHVSEIPGALKDPEKAKQLKDVKLVTWLPNDPEDPRNWSNTYRWYLTAVCAFSVVGVAFGSAVVTGDFGDIQDYFHVGEVVTALSVSLMVCGFGVGPLLWSPLSELVGRKPIWTIPSLIYVIFNIPCAVATNIQTLLICRFFSGFFASAPLTLAGGTISDLWDNNERGFAIALFAAAPYGGPVIGPIIGGFVGENLGWRWMLWINMIFAAVVFVLCCTIPETFAPVLLKRRAARLRKETGDPNITTEQDLFKASLSEIVIETLIRPFQMLATEPILLLMSMYIALIYGLLYAFFFSFPVVFLEEYHFDDGHFGLTFCSVLIGLGLALFVTPQIEKNYQKRAAAKGGHADPEDRLVGMMIGCWFVPISMFIFGWTSPPAVMPGGGNWVGPVSSGVPFGFGMVIIYFSANAYIIDAFPGYVASALAAKTVIRSGSGAAMPLFIEAMYHNLGNGWAASVWAFISIGMIPIPFLFYRYGKAVRARSKRAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J681</accession>
    <name>A0A2H3J681_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ArfGap-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WOLCODRAFT_111355</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH33158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J681"/>
    <dbReference type="STRING" id="742152.A0A2H3J681"/>
    <dbReference type="OMA" id="DVFGDIW"/>
    <dbReference type="OrthoDB" id="10266696at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08839">
        <property type="entry name" value="ArfGap_SMAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000010">
        <property type="entry name" value="Stromal membrane-associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051718">
        <property type="entry name" value="ARF_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044732">
        <property type="entry name" value="ArfGAP_SMAP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45705:SF14">
        <property type="entry name" value="ARF-GAP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45705">
        <property type="entry name" value="FI20236P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="3">
        <location>
            <begin position="13"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="119"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="139"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="166"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="194"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="230"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PCH33158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="389" mass="41391" checksum="1395372B42AD4154" modified="2018-01-31" version="1">MSRQDKATTERHAKILRELLKRPENKVCADCKRNDPRWASWNIGVFLCIRCSGIHRSMGTHISRVKSVDLDVWTPEQMASIQKWGNRLANLYWEAHLKPGHIPSDHKMESFIRSKYESRRWAKEGPPPSDPSTLDSQVPQTPASSAQPTAPAQPPQRASMPAESLVTVSASRPSATSRQPQSHQLLSASVANRAQQPVAQAATTQASQPTQPQASAATASTNELFSLDFTAPAPSATPSNSSTPAAPKKDVKQDILSLFSTPSAAPTAATAMGGFGQFAQVQNTWNNFDAQPAQQPVQPVSMAGATGVGMWGASSGWNATPVAPAQSNIWGTPAAQPAVSQQQSLFNTSDVWSSSGTTTGAGGSLFGSSLTSGTQKKDDAFGDIWGGFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J6H1</accession>
    <name>A0A2H3J6H1_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_167402</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467920">
        <property type="protein sequence ID" value="PCH37255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J6H1"/>
    <dbReference type="STRING" id="742152.A0A2H3J6H1"/>
    <dbReference type="OrthoDB" id="2801423at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH37255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="294" mass="32423" checksum="8C14F077254E505C" modified="2018-01-31" version="1">MPHNPSVSSRESSPSDDPVNAEIQAESAYSEATARSPTANIPPPQANVLASPWRWSPHAYVHPNYMPYHPPPTVHAPYSFPSSSSAHPSSTPVFDIPTLGSSPPSRSLSAIESLFVDEVFKDFTLPEISSVRSLSGWYTKLEIEDRVLLIFRCMRSLGFDTLGDLFAACLGNSYSKHPTVYHTIAAFVRSRGAVGKQPVDIINIMYSHPKARDLDNRKPIPPTFPSLPRHALPPSHRVAEDRLAVIPLESTQNQLLDWSLKQVLECVEREADMLTRSSTGAGLTVERGDSLSWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J6K5</accession>
    <name>A0A2H3J6K5_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">triacylglycerol lipase</fullName>
            <ecNumber evidence="6">3.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Autophagy-related protein 15</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">WOLCODRAFT_64899</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Lipase which is essential for lysis of subvacuolar cytoplasm to vacuole targeted bodies and intravacuolar autophagic bodies. Involved in the lysis of intravacuolar multivesicular body (MVB) vesicles. The intravacuolar membrane disintegration by ATG15 is critical to life span extension.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12044"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17855"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.3"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Binds to both phosphatidylinositol (PI) and phosphatidylinositol 3,5-bisphosphate (PIP2).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endosome</location>
            <location evidence="3">Multivesicular body membrane</location>
            <topology evidence="3">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Prevacuolar compartment membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.3" evidence="6"/>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH37846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J6K5"/>
    <dbReference type="STRING" id="742152.A0A2H3J6K5"/>
    <dbReference type="OMA" id="KEVITHV"/>
    <dbReference type="OrthoDB" id="58570at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032585">
        <property type="term" value="C:multivesicular body membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005775">
        <property type="term" value="C:vacuolar lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034496">
        <property type="term" value="P:multivesicular body membrane disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046461">
        <property type="term" value="P:neutral lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006660">
        <property type="term" value="P:phosphatidylserine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050805">
        <property type="entry name" value="ATG15_Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47175">
        <property type="entry name" value="LIPASE ATG15-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47175:SF2">
        <property type="entry name" value="LIPASE ATG15-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0072">Autophagy</keyword>
    <keyword evidence="8" id="KW-0967">Endosome</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 21" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="19" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013803342" description="triacylglycerol lipase" evidence="19">
        <location>
            <begin position="22"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal lipase-type" evidence="20">
        <location>
            <begin position="241"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00024663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00029828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="PCH37846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="430" mass="47368" checksum="8C38E9809724AB7A" modified="2018-01-31" version="1">MRTLTLSAPLFLSYGIHVVASLAPSGYQVPTPISFTSQQEYSLPANYDLDDRQYAFDIYDGLSGTPTFTLQARPTTVWRPKSTAAFQHARLRSLYTQESEEVEWEQVEMLGPYIEDKHTLSQLAKMTGNAYALPGQKNWYDIDPTWNHSFPFGWEDHANGFRGHVFLSPSNATVVLAIKGTTLQGPTSKKDKYNDNLLFSCCCARVDFSWVFSTVCKCYANHWRCDNTCLSNALIQDSLFYSTGVDLINNLTELYPTSTIWLVGHSLGGSLASLLGTTFGLPAVTFEAPGERLAAQRLHLPLPPAINSNSSSGGSPATHVYHSADPIPQGVCTGPMSLCAQAGYALETRCHMGKSIVFDTVGKLGWRVDVQTHTIKNVITKVLEAQVEGGWDTGADGSILDVPIAREEEDCVDCYKWEFGDFKDPSYGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J6R8</accession>
    <name>A0A2H3J6R8_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nuclear rim protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WOLCODRAFT_135950</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7 8">MD-104</strain>
        </source>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043007">
        <property type="term" value="P:maintenance of rDNA"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:regulation of exit from mitosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018819">
        <property type="entry name" value="Nur1/Mug154"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28293">
        <property type="entry name" value="NUCLEAR RIM PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28293:SF1">
        <property type="entry name" value="NUCLEAR RIM PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10332">
        <property type="entry name" value="DUF2418"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="329"/>
            <end position="352"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="75"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="PCH37950.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="411" mass="45816" checksum="8F1913ED267371DF" modified="2018-01-31" version="1">MSTRRATRQNSPGTPTPAPRPRRSAGTQATTAATATVPRDAPTALRGSVPYYTSPVLTESKSASVPFDWEAVRSRRPPPYGVSTPKRSRGVRQSDIGTPVHASPGWGTPGTRRERAVRKKSFLERIKALPSEIAFELSLFPDNIPRPAPDTSAWILGGFAHFVHLCVRIARIRQIPDSDLGWEDMYREGEDEPWFDWTVPATALLFGFAILNALYYFTRTKLYQLTMATEPVPSPHAAFVSRPHNARKDSDEDVPGPSGRVWPLIQSMLSRLWRAFVVSVRFLLNLSPPTSRRATLHGGSGNEKIQQLEVWTPGELEGRLFSIYSPVHALLWTAVTSASWMHMCCIMAVVGVQLRALTRAYEALLKDRAIIAAEVLHEYNAKFVNPRVNPIRKDVAVMTHQAEVVDYWTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J729</accession>
    <name>A0A2H3J729_WOLCO</name>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPP4R2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH38026.1"/>
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    <dbReference type="OMA" id="HMSDHPT"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:protein phosphatase 4 complex"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="PPP4R2"/>
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        <property type="entry name" value="PPP4R2-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16487:SF0">
        <property type="entry name" value="PROTEIN PHOSPHATASE 4 REGULATORY SUBUNIT 2-RELATED"/>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="28"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="192"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009207"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH38026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="265" mass="28783" checksum="0BC2E9AA84AC70CA" modified="2018-01-31" version="1">MLRDVIKQRIDQNIALFLSGQVKGEYNRSTVKAAPRPGGLKLPSFPSRPRDPSNPNEAPKNILTEQEAADFKQSIFAQLDEFEQSPPFTIQRLCELCLRPTEHYKFLGKYLRAVEKTLLVTSTWDAFPISQEQANGQPAIGHAPVSINTLSAPTTPIFSPIPFLHEDARRSSSRSPPPSPLVLPAMEAATTMPHAGAESSEQKALGLVDELDDPSPGHLSEHPQALSATTTVTSPKPLLLGSLEERFVKAKTDSEGEGSKGGKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J8C6</accession>
    <name>A0A2H3J8C6_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein 60S</fullName>
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    <gene>
        <name evidence="5" type="ORF">WOLCODRAFT_28309</name>
    </gene>
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        <name type="common">Brown rot fungus</name>
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    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
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                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein P1/P2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467865">
        <property type="protein sequence ID" value="PCH36033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J8C6"/>
    <dbReference type="STRING" id="742152.A0A2H3J8C6"/>
    <dbReference type="OMA" id="SQETACV"/>
    <dbReference type="OrthoDB" id="2194681at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030295">
        <property type="term" value="F:protein kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006414">
        <property type="term" value="P:translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05831">
        <property type="entry name" value="Ribosomal_P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1410:FF:000001">
        <property type="entry name" value="60S acidic ribosomal protein P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01478">
        <property type="entry name" value="Ribosomal_L12_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038716">
        <property type="entry name" value="P1/P2_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027534">
        <property type="entry name" value="Ribosomal_P1/P2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45696">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45696:SF10">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00428">
        <property type="entry name" value="Ribosomal_60s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="72"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="72"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PCH36033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="110" mass="11033" checksum="EDF79680179961A0" modified="2018-01-31" version="1">MASTELAATYAALILADEGVEITSDKIVALTSAASVELEPIWASLLAKALEGKNVKELLSNVGAGGGAPAVGAPAAAGGAAAAAEAPKEEEKKEEEKEESDDDMGFGLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J8F4</accession>
    <name>A0A2H3J8F4_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_23168</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH38221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J8F4"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH38221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="57" mass="6409" checksum="4B8940E18E89CE83" modified="2018-01-31" version="1" fragment="single">MSVPELFMSTAREQLYQTVGAVEYEMRHQHVASTSRECGLNLRTLVAYSCAGILVFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J8Y3</accession>
    <name>A0A2H3J8Y3_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">WOLCODRAFT_97488</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">MD-104</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH38680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J8Y3"/>
    <dbReference type="STRING" id="742152.A0A2H3J8Y3"/>
    <dbReference type="OMA" id="RTHDEDM"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PCH38680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="315" mass="35575" checksum="D599E5A208153DCF" modified="2018-01-31" version="1">MDNDFSESVLPGAFLEDSLPIMKYLPDWCPGTGYRAIVKERLHTRLRARDEAFNMVKEQLARGTASPSLVAELLENNPNRTHDEDMLFRDVTNTFYAGAADTTVSAIESFFLIMCIYPELQRKAQTELDGVVTPGHLPTFADRQRLPYIDALIKEVHRWNPVGPTGVPHKVMEDDVYKGFRIPAGATVIGNSWQVLLMFRAYYTDLTFTTIRAILHDPALYPDYFEVIPDRYLQTKDNGLNPNPRKFVFGYGRRVCPGQMLAEDSLYIVAVLALSTLSICCTDLQGQSLPNEVEYDGAVVRFVNCNHTEGWSAHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J9A9</accession>
    <name>A0A2H3J9A9_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WOLCODRAFT_140385</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
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                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
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                <person name="Kumar T.K.A."/>
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                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
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                <person name="St John F."/>
                <person name="Stenlid J."/>
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                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
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                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Barry K."/>
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                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
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                <person name="Ferreira P."/>
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                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
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                <person name="Heitman J."/>
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                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
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                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="60" mass="6231" checksum="BEA470BE78746C8C" modified="2018-01-31" version="1">MIRTLKPGPDTMVAMMPYLHLGLEIVRLGATAHSGGIAIGTIRVEACMALHSAAGLSEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JAV1</accession>
    <name>A0A2H3JAV1_WOLCO</name>
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        <submittedName>
            <fullName evidence="2">GroES-like protein</fullName>
        </submittedName>
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    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_85458</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467987">
        <property type="protein sequence ID" value="PCH39326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JAV1"/>
    <dbReference type="STRING" id="742152.A0A2H3JAV1"/>
    <dbReference type="OMA" id="KKQGQWI"/>
    <dbReference type="OrthoDB" id="3233595at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="13"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH39326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="346" mass="36012" checksum="F1580028179B985F" modified="2018-01-31" version="1">MSQNSLLLTAKQGSFAVGTTPIPKPGPGQVLIKIQSAALNPLDWKIQAYGLFIEKFPSVLGNDIAGTIEAVGEGVTGFAKGDRVLNQGIIGNNEFSGFQQYALANADVTAKIASSLSFDQAATVPAGLATAALGLFNQGKSNSAGLYPPWEEDGSGRYAGQPIVIFGGASSVGQYVIQVAKLAGFSPIITTASLTNADYLRGLGATHVLDRKLSAEQLKAQVSSITSASIQIVYDAISEADTQVAAYDLVSSGGTLVLVLANSIPESKRTSDKKIVNVYGVVNAPENRATGASLYNQLTRLLENGSIKPNRVEVLPNGLQGIVDGLKKLQAGISSIKLVAHPQETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JB36</accession>
    <name>A0A2H3JB36_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_157722</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467909">
        <property type="protein sequence ID" value="PCH37023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JB36"/>
    <dbReference type="STRING" id="742152.A0A2H3JB36"/>
    <dbReference type="OrthoDB" id="2758170at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046521">
        <property type="entry name" value="DUF6698"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20414">
        <property type="entry name" value="DUF6698"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH37023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="293" mass="32548" checksum="C9F8CE4FB3679532" modified="2018-01-31" version="1">MHAGEIEADASDLPSFLYPKNGYDEEKPEQNLLMSPILVVNFRCLFKGPSAAQSFSVMDAKKGGGCPPLCKIYSLDEVTPEQIAYTAMITRFRYVSQNIWDDNDGTFFGAEFYTYILRVFKVDADWAVEVYGKDTQTVAPNGIKIRKREGPSLIEKINKQLAEASKAASHPESDDLPIPLRRKSLLGLFESFNDDEGEEAVAAQVDGEEQVEVQVDSEEQVEEQADGEEQVEEQADGEQAKGVDELMEEDGEGEHLSISMEIRFAPAQVFAGRSLCCVRPPPPPPRHQQSARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JBK0</accession>
    <name>A0A2H3JBK0_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PhoD-like phosphatase metallophosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_110896</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468009">
        <property type="protein sequence ID" value="PCH39566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JBK0"/>
    <dbReference type="STRING" id="742152.A0A2H3JBK0"/>
    <dbReference type="OMA" id="FPYHPAQ"/>
    <dbReference type="OrthoDB" id="2100241at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07389">
        <property type="entry name" value="MPP_PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.70">
        <property type="entry name" value="PhoD-like phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018946">
        <property type="entry name" value="PhoD-like_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038607">
        <property type="entry name" value="PhoD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052900">
        <property type="entry name" value="Phospholipid_Metab_Enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43606:SF2">
        <property type="entry name" value="ALKALINE PHOSPHATASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G03860)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43606">
        <property type="entry name" value="PHOSPHATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G08710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09423">
        <property type="entry name" value="PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PhoD-like phosphatase metallophosphatase" evidence="2">
        <location>
            <begin position="377"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="604"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="614"/>
            <end position="629"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH39566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="783" mass="87307" checksum="79B770D9904F2409" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JBS9</accession>
    <name>A0A2H3JBS9_WOLCO</name>
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        <recommendedName>
            <fullName evidence="6">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WOLCODRAFT_141073</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD-104</strain>
        </source>
    </reference>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        </location>
    </feature>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH39035.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JC42</accession>
    <name>A0A2H3JC42_WOLCO</name>
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        <submittedName>
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        </submittedName>
    </protein>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
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                <person name="Stenlid J."/>
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                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD-104</strain>
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    </dbReference>
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    </dbReference>
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        <location>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
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    <name>A0A2H3JCF9_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sec1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_161985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
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        <property type="protein sequence ID" value="PCH39952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="742152.A0A2H3JCF9"/>
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    <dbReference type="OrthoDB" id="10266265at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
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        <property type="entry name" value="Sec-1-like_dom1"/>
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        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
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        <property type="entry name" value="Sec1-like"/>
    </dbReference>
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        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
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    </dbReference>
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        <property type="entry name" value="VPS45_Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH39952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="642" mass="70909" checksum="156D3EA74CF0B083" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JCU6</accession>
    <name>A0A2H3JCU6_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Adhesion regulating molecule</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WOLCODRAFT_131194</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="PCH40070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="742152.A0A2H3JCU6"/>
    <dbReference type="OMA" id="SNQRHFF"/>
    <dbReference type="OrthoDB" id="340431at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061133">
        <property type="term" value="F:endopeptidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13314">
        <property type="entry name" value="PH_Rpn13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.70:FF:000001">
        <property type="entry name" value="Proteasomal ubiquitin receptor ADRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2020.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.70">
        <property type="entry name" value="Proteasomal ubiquitin receptor Rpn13/ADRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DEUBAD_dom"/>
    </dbReference>
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        <property type="entry name" value="Rpn13/ADRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044868">
        <property type="entry name" value="Rpn13/ADRM1_Pru"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RPN13_DEUBAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038108">
        <property type="entry name" value="RPN13_DEUBAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12225">
        <property type="entry name" value="ADHESION REGULATING MOLECULE 1 110 KDA CELL MEMBRANE GLYCOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12225:SF0">
        <property type="entry name" value="PROTEASOMAL UBIQUITIN RECEPTOR ADRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04683">
        <property type="entry name" value="Rpn13_ADRM1_Pru"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16550">
        <property type="entry name" value="RPN13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51916">
        <property type="entry name" value="DEUBAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51917">
        <property type="entry name" value="PRU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pru" evidence="8">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="DEUBAD" evidence="7">
        <location>
            <begin position="186"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="123"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="133"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="150"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PCH40070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="302" mass="32728" checksum="DAFC40379839740E" modified="2018-01-31" version="1">MTEPRIAFKAGRCFRREGTNFVDPNPTKGAIILQNGEDGLLHFMWKNRVTNEIEEDLILFPSDASFNKVEQSAWGRTYVLKFSSSDQRHFFWMQDADASRDVEFVGNVNRLLNDPQTIPIWWAPGYNPGSDPGASTSSQPAAGSSLTPEAGSSQPAASSQPAAGTIGFQATPEQLAQLQQIIAGLPGSQPQHPVEVSLTDILTPANLTPLFSSHPELVQALFPQLPPDLPTPPSEEALQRIISSPQFRGAVRNFDQALRTGLLGGLVRGLGLPEEAGTSVEAFLRAIQEQANSESADHMDTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JD55</accession>
    <name>A0A2H3JD55_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_112731</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
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                <person name="Barry K."/>
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                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
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                <person name="Benoit I."/>
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                <person name="Ferreira P."/>
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                <person name="Gaskell J."/>
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                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
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                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
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                <person name="Nagy L.G."/>
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                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
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                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
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                <person name="Spatafora J.W."/>
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                <person name="Benoit I."/>
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                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
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    </dbReference>
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    </evidence>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
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            <authorList>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
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                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD-104</strain>
        </source>
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        <property type="protein sequence ID" value="PCH40530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Ssr4_N"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SWI/SNF and RSC complexes subunit Ssr4 N-terminal" evidence="3">
        <location>
            <begin position="21"/>
            <end position="135"/>
        </location>
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        <location>
            <begin position="208"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="287"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="232"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PCH40530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="341" mass="37905" checksum="D226A0EB9A186180" modified="2018-01-31" version="1">MAGHSLPEGICLRYPEHITPQLNLAPEAAVQMLLRATQLAMGTPFQWGYIDKPSDGQIFLIFITANLGLPPDGIRYLEQEQKGVLQAGPGRELEMMEVKFGFIPGQDTAAYRVRRRYRLIRGGHPQLVLIHYGRGQATAIPPSINQPVRAYPLRPFNEPGMYVMGEKAGQKVYPPGMDRAPGMAMGFPAGMAGNPQAMLAQQNSNMEALERRQRGVSVGMSQRQPVQQRPVEDDDSADESETVSTRTLAATRFRRNHEYMWEVFTHAAFSKLKEVDNRPPPYSIFNQEELEAKVAKLSAEVEELEAKAAARRRAEEALQSVDEMLDVPMDALGAQGEGVMT</sequence>
</entry>
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            <fullName evidence="2">Uncharacterized protein</fullName>
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            <taxon>Phaeolaceae</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
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                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
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                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
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                <person name="Lundell T."/>
                <person name="Martin R."/>
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                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
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                <person name="Stenlid J."/>
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                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468081">
        <property type="protein sequence ID" value="PCH40640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="106"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH40640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="224" mass="24064" checksum="6F6A71B40F8F46E5" modified="2018-01-31" version="1">MPLPSEDDTVATILKLIDRENPGIAYSQLIASLGGCSHCGQCMGVNMFLYHHCPPLDPDVKPLRGMGLAMHIPPACHSPLAFKPEPSPLPTRLPTPPVIRARYSSISHDTASGSGSSSSRSQPLDRLFMPGHPGRNEPNAVDLFCADEAHIVPVPHSQKRKRDESDPSIPSSAHFGPALQHSKREAGPSVIDMTEDEGRSDVIDLTKGEVVGSADVIDLTKDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JF47</accession>
    <name>A0A2H3JF47_WOLCO</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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        <name evidence="1" type="ORF">WOLCODRAFT_156042</name>
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    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
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                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
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                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467843">
        <property type="protein sequence ID" value="PCH35344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JF47"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH35344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="50" mass="5704" checksum="2CEEE797446697BE" modified="2018-01-31" version="1">MWKPNEELLIIDEQGNEAQTAWDNRKRVPNHCLDAIATKLHLHQAVGSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JF75</accession>
    <name>A0A2H3JF75_WOLCO</name>
    <protein>
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            <fullName evidence="6">Postreplication repair E3 ubiquitin-protein ligase RAD18</fullName>
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        <alternativeName>
            <fullName evidence="17">Postreplication repair E3 ubiquitin-protein ligase rad18</fullName>
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        <alternativeName>
            <fullName evidence="16 18">RING-type E3 ubiquitin transferase RAD18</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">WOLCODRAFT_161580</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25 26">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RAD18 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH38443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JF75"/>
    <dbReference type="STRING" id="742152.A0A2H3JF75"/>
    <dbReference type="OMA" id="AKSEYEP"/>
    <dbReference type="OrthoDB" id="9049620at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097505">
        <property type="term" value="C:Rad6-Rad18 complex"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006301">
        <property type="term" value="P:DNA damage tolerance"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000172">
        <property type="entry name" value="E3 ubiquitin-protein ligase RAD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Rad18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004580">
        <property type="entry name" value="Rad18_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006642">
        <property type="entry name" value="Rad18_UBZ4"/>
    </dbReference>
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        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00599">
        <property type="entry name" value="rad18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14134">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RAD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14134:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RAD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00734">
        <property type="entry name" value="ZnF_Rad18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51908">
        <property type="entry name" value="ZF_UBZ4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 20" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14 20" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 19" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="22">
        <location>
            <begin position="39"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="UBZ4-type" evidence="24">
        <location>
            <begin position="203"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="SAP" evidence="23">
        <location>
            <begin position="296"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="116"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="224"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="393"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="160"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="180"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="224"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="403"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00015551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00074353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00082369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="PCH38443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="438" mass="47988" checksum="0EA9D424A9733FC4" modified="2018-01-31" version="1">MVATDLQSLLDAPDAHDPTDFPPQDVAPGLRLLDDSLRCSVCRDFYDAPMSINCGHSFCSLCIRQALDAKQECPSCRQPATEAHLRKNTAAESAVKAWSESREFILRLSKAEERRHVGDLPAANGSSGHEDSEQRPRKRQRTLSEEDSDAEVEYLGGTSPYFSSRGSATNSHIRAQETGLPSKSQSQSDSPLSEHRSPNSSSVVECPLCQRRVPLESINQHIDSGCTLTPSAGGPSSSRPHASRAGSRDKDKQKAQWTKLFDGGSGAAPPSRRSKEKQKERASEAGEAEYLPKVAYATLKDRRLQEMLAEHGLPTAGDRAAWERRHQKWVTLYNANADRAPADQQSPAQLKRALKRWEDGLRAANARRAAADVDAGAHQRANSAAFRELVEAARPKKAAGTGREGRAGEDGRETTGMQDNSLIIVQRTLDVRKHNLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JF94</accession>
    <name>A0A2H3JF94_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_131583</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH40886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JF94"/>
    <dbReference type="STRING" id="742152.A0A2H3JF94"/>
    <dbReference type="OMA" id="CKVITAE"/>
    <dbReference type="OrthoDB" id="41403at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004487">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004488">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01079">
        <property type="entry name" value="NAD_bind_m-THF_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000401">
        <property type="entry name" value="Related to MTD1-methylenetetrahydrofolate dehydrogenase (NAD+)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035812">
        <property type="entry name" value="m-THF_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020630">
        <property type="entry name" value="THF_DH/CycHdrlase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020631">
        <property type="entry name" value="THF_DH/CycHdrlase_NAD-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099">
        <property type="entry name" value="C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099:SF3">
        <property type="entry name" value="METHYLENETETRAHYDROFOLATE DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00763">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02882">
        <property type="entry name" value="THF_DHG_CYH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic" evidence="1">
        <location>
            <begin position="12"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding" evidence="2">
        <location>
            <begin position="178"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH40886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="351" mass="38329" checksum="069CE7B28BE1A524" modified="2018-01-31" version="1">MSTEASGKGILLKADPIANAFRDEIKAALAERPRPPKLVGILATSAAPSKFYADFTQKQCDALGVEFVLKRTGAAADPSAGEGDGVEEAIIEANEDNSVDGIMVYYPIFGVQQDHYLQQVVSPLKDVEGLHFKFHYNLYHNIRFLDPTSLLSSVPPTSLPPPAVEDQPPAGTVKSILPCTPLAVVKCLEHIGVYNRILPYGDRAYGKTITVINRSEVVGRPLAALLANDGARVLSVDIDSIQEYTKRPVTEAERRFHPRHVVRPSSLSLQECLAISDVVVSAVPSAEYKVKTAWLKDGCVCINVAADKNFEADVREKASVYMPTIGRVTITMLLRNLLRLQQYGEVSKQTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JFI5</accession>
    <name>A0A2H3JFI5_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WOLCODRAFT_151003</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH40970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JFI5"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="142"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="97"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="148"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="105"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="157"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="170"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="186"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PCH40970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="228" mass="25857" checksum="C9F6E03DBE412263" modified="2018-01-31" version="1">MTQVCVKTNDNLFDIKQDKKSIDDFNIKFDNLIGKTGLDRQQCDRLFVTMYKRAIRPALVTHIINIVPPIVTLTEWMKQASINENNYNTFIKGWGNDKKKPQWRAKAPSASTPAAPAKDPNAMDIDQMSTEERRRLQTEEQCFNCKEKGHLSSNCPKQKKKSSPKGKTWKAKEETPAAHDEGAKEDTDDDDDDNDGATAIEEAVNVIRVLKAKNPSFLAQILDEQDFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JHL5</accession>
    <name>A0A2H3JHL5_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CCT-beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WOLCODRAFT_137539</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD-104</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH41676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="742152.A0A2H3JHL5"/>
    <dbReference type="OMA" id="CAEMVMS"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03336">
        <property type="entry name" value="TCP1_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.260.10:FF:000025">
        <property type="entry name" value="Chaperonin containing TCP1 subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000002">
        <property type="entry name" value="T-complex protein 1 subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000017">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012716">
        <property type="entry name" value="Chap_CCT_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02341">
        <property type="entry name" value="chap_CCT_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PCH41676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="524" mass="56597" checksum="F746ED2BF6FB5295" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JHR4</accession>
    <name>A0A2H3JHR4_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WOLCODRAFT_27969</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
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                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">MD-104</strain>
        </source>
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            <end position="70"/>
        </location>
    </feature>
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            <end position="111"/>
        </location>
    </feature>
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            <end position="211"/>
        </location>
    </feature>
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    </feature>
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    </feature>
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        </location>
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        </location>
    </feature>
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            <begin position="482"/>
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        </location>
    </feature>
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        </location>
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    </feature>
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</entry>
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        <lineage>
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            <taxon>Phaeolaceae</taxon>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
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                <person name="Martin R."/>
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                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
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                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
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                <person name="Sabat G."/>
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                <person name="Wiebenga A."/>
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                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
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            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD-104</strain>
        </source>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        </location>
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            <begin position="326"/>
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    </feature>
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        </source>
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        </source>
    </evidence>
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            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH42116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="340" mass="38204" checksum="7298D85DFDF5A3A4" modified="2018-01-31" version="1">MTSSASKLILVMGATGAGKTTFVNLISHSNLEVGHGLASCTADMQIVEMEFAGQQITLVDTPGFDDTERPQADVLKQIATFLQRTYEGGRKVDGLIFMHRISDNRMGGTAVSNYRLFSRVCGEGAMKNVVIVTNMWNEVLPEMGVARERELRETFFAKELSHGARMLPHDATERSARAIMQELIGNQAETLLVQTEMVHEKKSIPDTQAGTELDRELTAMEERHRSQIQQLVGELRSALTQKEQMEHELDGIRRKLIEVELEKVKLREALKEEVAAKLATVIRQAMKQPDAHSPTTWGHRLSQQVFDDNCNQPSSPPDSPPGSPAKGRRNRKRWWKRLVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JK60</accession>
    <name>A0A2H3JK60_WOLCO</name>
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        <submittedName>
            <fullName evidence="12">General substrate transporter</fullName>
        </submittedName>
    </protein>
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        <name evidence="12" type="ORF">WOLCODRAFT_163632</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
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                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
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                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
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                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="MFS sugar transporter, putative"/>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="MFS_dom"/>
    </dbReference>
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        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF80">
        <property type="entry name" value="SUGAR TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12170)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
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        <location>
            <begin position="176"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="66"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PCH42636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="234" mass="24967" checksum="0C189327E116A173" modified="2018-01-31" version="1">MPPPSDPQAAALLAHVLSQTHQNIAFLASQNYITPADAAEITARLSAHQSNSLAEDMSITARREPSPPPPARRIPPPPPRAQRARALWAYNEDGREPNDLSFSSGEIVEVIDETNADWWTGRCRGRQGLFPSNHVEKIAPGPSPPPNVPSPPMPMAQMPPPQPMYAAPMEKPVYNQYAMQPPPPQPVVVQQAPPPEPKKSRFGGLGQTMATSAAGGLGFGAGAAIGSDLINSIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JKV7</accession>
    <name>A0A2H3JKV7_WOLCO</name>
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        <recommendedName>
            <fullName evidence="4">Geranylgeranyl pyrophosphate synthetase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_98991</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OMA" id="LWFSQTP"/>
    <dbReference type="OrthoDB" id="420564at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35179:SF2">
        <property type="entry name" value="START DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH40483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="407" mass="45955" checksum="6CB1784A9DD2EBF9" modified="2018-01-31" version="1">MRRGASRPVETFSLPPDRDIMDGLSRSPIRTLSKPEEDQGKAIVIKNFQYVGSYNWTDSTKPTIIIPGSPPEWRDRSLPYVVPPDSGIRFVDQNGYRMPSSTLHPLLRAVDITAEDAGDEFDWSTVDFVTDRNGLRKILRWINDHDGSAKEFRIETQLAGKRTVLFSRWEKRTREAPNSTFTTYGFSFERESTTKAPGCEKGTGHHRIVKYSFDGLVLVVRFEVDACIAPSRSSRATAAGPTDVDSLSDMLSGLNVASDKKGAAKVDESVSTPELDVIRAGTRVPQSSVIEMCTRSRRNAEQFDWVDAFPQLYFSQTPNHYLAVHSRGEFETITKKHLDNPEMKSIEASAQSGFRKLKRTLQDIQELVIEHGQRGRLSLVHRDGQLRVFERTSQTDSIPEQLLSRFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
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    <name>A0A2H3JKX2_WOLCO</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="2" type="ORF">WOLCODRAFT_149327</name>
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        <name type="common">Brown rot fungus</name>
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        <lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
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                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
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                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000218811">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH38388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="404" mass="44820" checksum="A606E52730845841" modified="2018-01-31" version="1">MRPNPELMTEDCSEQDDLHARPSANDILPVVADGDCQQRAFWAAPPPYSQRFGENKPHQVQHKDMGAFVEHPPARRRCEANESLTGIETAPCERRRASCAVPDGSSIQCRPHTGVREQYVECEHGQRPRANCGRQKHALGTEHGRLPRACVRADETGRRSTRCRARATTLLGKMLSQHMSVIVAEKWDRVAYVLRSASVSRTPTPHASIPDVRWSGRGGDPILHPGGPHEQRGALLAAWPRSGLTMRAPASKISFRFRTRSVHGCSPSLVGDRAGGDHTRTLIINVRVPRPISIRRGQQKSSRETRTSPGPYASLRPPPPHQTKSHKPTARRAAVAGAVLAVLRPRGDPRRENCAARRCTLLAANVRLRRRGSSRSPALRCRRAVTQPGTRLITRDTHTQISRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JL78</accession>
    <name>A0A2H3JL78_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
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    <organism evidence="4 5">
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        <lineage>
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            <taxon>Phaeolaceae</taxon>
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    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468135">
        <property type="protein sequence ID" value="PCH42950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JL78"/>
    <dbReference type="STRING" id="742152.A0A2H3JL78"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="152"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="219"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="170"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="219"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="232"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PCH42950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="258" mass="28023" checksum="0B822C7C169F7B84" modified="2018-01-31" version="1" fragment="single">MHTNQQYTCPGNDCSKAFGTPSAVIQHLESSACTSGMTRQRVNRMAIAADRGAVITDRARIAADNERLSMPESVATTAWFNGSSYECIICHRTCRTLVGLNRHLRSPAHSEKIFKCPRQWSGCGKAFNTLSGLVQHVESGVCGVRKFAPELSPGSGGRLQISFPDDETTGRTSGTSQYTPQPLRTESAGYSSSSYPRRRTYAESIQSFPGAASNISFASSTKYSSPASSQSNTYTRRSTYGELQQSFPEPRSYTPAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JLK3</accession>
    <name>A0A2H3JLK3_WOLCO</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_144199</name>
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    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="PCH42761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH42761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="462" mass="52494" checksum="F781F18AE329E212" modified="2018-01-31" version="1">MPNLCFNAYSALRAWQVLTSEAEMQQQDISGPCTNAGQLIDVDTLALYECVTSPDQDSVEDMAKDLDALMLSIGAQYPSTWTVLQPIPLLCRVSPYLDLASVGSMFQYGRRNCGQFLLDYSDPMTKYIADFPYSDILVMFKFMHSLGCYIRIERVKDKTLGEVVEEISTAFEKYWKIIGGVSLDQSGSIVENEDECDVHICRIPDGADDSAVTKEEEHIIHQLNSQLIFPEGLMHIVHNIFRVSMVVGPNPLMIGSDPNITPPWYMTTTRTNALEPVVLLPTEKFDFFSMSLFDINKTEFPPVEPFFFQYIAECHNHKAGVHTYPTFSDLDQWSDEYAKLENASWMPFSAGWPSTEIRIWYYWPDSNENEAYQNVVTIPNISPNTRLKDLARATGTACKHFIYDQCNIASNNLPVIIRMTPYPRFYRKRDGTILEIKNDSSIYLAGLSHVSGTNVFRALLMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JLY5</accession>
    <name>A0A2H3JLY5_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WOLCODRAFT_137049</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH40873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JLY5"/>
    <dbReference type="STRING" id="742152.A0A2H3JLY5"/>
    <dbReference type="OMA" id="LFWQVTR"/>
    <dbReference type="OrthoDB" id="5327538at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072354">
        <property type="term" value="F:histone H3T3 kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024604">
        <property type="entry name" value="GSG2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24419">
        <property type="entry name" value="INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24419:SF18">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE HASPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12330">
        <property type="entry name" value="Haspin_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01331">
        <property type="entry name" value="DUF3635"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Serine/threonine-protein kinase haspin C-terminal" evidence="10">
        <location>
            <begin position="588"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="119"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="683"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="163"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="191"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="202"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="219"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="274"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PCH40873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="722" mass="79264" checksum="BD2CD315B6BD164B" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JM36</accession>
    <name>A0A2H3JM36_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome b-c1 complex subunit 2, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WOLCODRAFT_25816</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the peptidase M16 family. UQCRC2/QCR2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB468135">
        <property type="protein sequence ID" value="PCH43260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JM36"/>
    <dbReference type="STRING" id="742152.A0A2H3JM36"/>
    <dbReference type="OMA" id="APKFALY"/>
    <dbReference type="OrthoDB" id="6369905at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000021">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000039">
        <property type="entry name" value="Ubiquinol-cytochrome c reductase core subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050361">
        <property type="entry name" value="MPP/UQCRC_Complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851:SF209">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851">
        <property type="entry name" value="METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="11">
        <location>
            <begin position="30"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="12">
        <location>
            <begin position="178"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PCH43260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="423" mass="43419" checksum="B66E49BCCCB837D6" modified="2018-01-31" version="1">MLAARASAARSASRLARNYASVVDTAGVKVAAVDNGEPTSAVTFLVKAGSRFESKPGVAHALKGFAYKSTNKRSFLGTVREAELYGGVLSTSLSREHLALSAEFLRGDESFFVDVLSSFVTSAKYTRHELDEYVAPVCEAESTTALANPATRALDLAHLLAFRAGLGSSPYTSPGAHVSVEDVKAFAKSVFTPGNIAVLGTGISSEKLQTLLAQSLGGLSSASAPTSAPSAYFGGETRVEAHGAPETVFIGFGAAGVPSAELAVLAAHLNPKPSVKWAQGLSPIAVKLPQGTSVQSVLLPYSDASLFGLLVQGPTTAAVKEAGKAAVTALKTAGEIQGEELKKAVAKAKFAAASSVDYRDGLAFALGAKALGSFASLDGTLSNLEKVEASAYSKATASLLKSKPTYVVVGDIKSLPYADELGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JMQ6</accession>
    <name>A0A2H3JMQ6_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alcohol dehydrogenase IV</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WOLCODRAFT_103563</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468146">
        <property type="protein sequence ID" value="PCH43470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JMQ6"/>
    <dbReference type="STRING" id="742152.A0A2H3JMQ6"/>
    <dbReference type="OMA" id="HTAHYNH"/>
    <dbReference type="OrthoDB" id="3360544at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08192">
        <property type="entry name" value="MAR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1090.10">
        <property type="entry name" value="Dehydroquinate synthase-like - alpha domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056798">
        <property type="entry name" value="ADH_Fe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018211">
        <property type="entry name" value="ADH_Fe_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039697">
        <property type="entry name" value="Alcohol_dehydrogenase_Fe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496:SF97">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE IRON-TYPE_GLYCEROL DEHYDROGENASE GLDA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25137">
        <property type="entry name" value="ADH_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56796">
        <property type="entry name" value="Dehydroquinate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00060">
        <property type="entry name" value="ADH_IRON_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA" evidence="2">
        <location>
            <begin position="16"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Fe-containing alcohol dehydrogenase-like C-terminal" evidence="3">
        <location>
            <begin position="205"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PCH43470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="381" mass="41172" checksum="2B502689483D5EBD" modified="2018-01-31" version="1">MADLHGQYDWSCPLRSVYYGPGCLSTTLPKLLDRLNVKAAMIVTGQSLFSKTDVVKKVEAVLKHHSAFVGTFYDIGQHSPIANIRNGVQSLRNCGADAIVSIGGGSPIDAAKVMIHLRLQDNGGAMLTHIAIPTTLSAAEFSIVGGYSDQTGSKVTICDPQIIPAAIIMDAELTLATPERLWLSTGMRALCPEILNRPLVPPPVKHLCYAALADLFKYLPECKANPEAVSVRQKLQLVAWMSYWPINIEYKGIGLSHTLGHKLGATYHIPHGITSCLTLAPVVALKAQVATEEDKEWLAGALFHLREPSTGSLDSDVFKLSGLIIDRVASRLVAELGLTSTLKEYNVPRSDPPNIAERALGSRADSVYPRVVTLLEGLYAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JN14</accession>
    <name>A0A2H3JN14_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_73999</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468135">
        <property type="protein sequence ID" value="PCH42885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JN14"/>
    <dbReference type="STRING" id="742152.A0A2H3JN14"/>
    <dbReference type="OrthoDB" id="406505at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22191">
        <property type="entry name" value="DPBB_RlpA_EXP_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051477">
        <property type="entry name" value="Expansin_CellWall"/>
    </dbReference>
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        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836:SF29">
        <property type="entry name" value="RLPA-LIKE PROTEIN DOUBLE-PSI BETA-BARREL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013890945" evidence="2">
        <location>
            <begin position="21"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH42885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="140" mass="15019" checksum="90F08361F5FA6034" modified="2018-01-31" version="1">MSRLAMFAAALVGLASVVSASPVADNTVLDKWVTHEGWATWYDAGLSACRYTDSDSNYIVAISHDIYGSGGNCNQWIAITWNGATHYGKTRDECEACDATNDTSCNLKPTPGKGGSHKGAFLVPGLEDVTWHFMAKGWSP</sequence>
</entry>
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    <accession>A0A2H3JNA7</accession>
    <name>A0A2H3JNA7_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_140890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467931">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH37487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="492" mass="56176" checksum="9EC6AD468B267827" modified="2018-01-31" version="1">MASSSKRLSSYKMANEIDGQPAAPRIVKRLAFDIKARILRAIKWRPREKPREPFFWREDALLPLFNSETVAFRIPIEIWDKILGCLQDDPETLSATEKVCRAWYPTSRRLRGDCYRNEFHSMEDVRLYARYIKTVPKLRRNTPLLPFTIWGEGKQRGLAHLGTFAAMFAGGQLPDLLSLGIREGEWMPGSIPQSMFLYLSTFHSITRLTLSSITLPSISVLLRLVCAFDRLENLGIGYLRLLDRRVPPANKRWAPSVYLKMLDFNFTTVDWPDHLYMISTCAEPETSSSSEIIPLISTAASCSHPQQLLHHAGKAIRELGITMHCLPPDRDPRSIEPVRVPNLDLSKNVGLKELEIDIVEHNLLMKVEIYDVIQQIISSTSHTALEKILINLDFRHSEAGPSASIMSDVLLALRKAVCHPDHPSVLEKYTSLKEVTLQFYETAESSKRQMEADWDKLAPTWFPGLYSRGMIKLEVRELGQSLYNPFSRDDQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JNG2</accession>
    <name>A0A2H3JNG2_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WOLCODRAFT_128568</name>
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    <organism evidence="4 5">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467931">
        <property type="protein sequence ID" value="PCH37547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="742152.A0A2H3JNG2"/>
    <dbReference type="OMA" id="RVFYFNR"/>
    <dbReference type="OrthoDB" id="9936937at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058841">
        <property type="entry name" value="HTH_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040554">
        <property type="entry name" value="KPWE_PEX14_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36855">
        <property type="entry name" value="CHROMOSOME 10, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36855:SF1">
        <property type="entry name" value="PEROXISOME MEMBRANE ANCHOR PROTEIN PEX14P N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25871">
        <property type="entry name" value="HTH_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17733">
        <property type="entry name" value="KPWE_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PEX14-like helix-turn-helix" evidence="3">
        <location>
            <begin position="20"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="Peroxisomal membrane protein PEX14-like KPWE" evidence="2">
        <location>
            <begin position="111"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PCH37547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="163" mass="18038" checksum="4593723B7F1935A8" modified="2018-01-31" version="1">MLSSELTESYGGNREVPVDLFLQHDFAEDATYQEGLAGIIASGALEGKSEEEKADIVRRSELFYFNRKYGYSISLEDARARQCASALELSAEESQPTPSLSSIPPAPPEEPRTLTFAELKVLIEQGKTDQIPNNRIIPNELNKSPPSTSAASVRRKPWEAERP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JPX8</accession>
    <name>A0A2H3JPX8_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">1-phosphatidylinositol 4-kinase</fullName>
            <ecNumber evidence="2">2.7.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WOLCODRAFT_142388</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19877"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.67"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.1.67" evidence="2"/>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH38077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JPX8"/>
    <dbReference type="STRING" id="742152.A0A2H3JPX8"/>
    <dbReference type="OMA" id="TQDYVDV"/>
    <dbReference type="OrthoDB" id="10264149at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004430">
        <property type="term" value="F:1-phosphatidylinositol 4-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
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            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
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                <person name="Barry K."/>
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                <person name="Martinez A.T."/>
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                <person name="Boyd A."/>
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                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
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                <person name="Kallen N."/>
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            </authorList>
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</entry>
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                <person name="Yadav J.S."/>
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                <person name="Heitman J."/>
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    </evidence>
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        </source>
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        </source>
    </evidence>
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    <name>A0A2H3JQE5_WOLCO</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 11">Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="11">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="9">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with zinc, cobalt, manganese or divalent iron ions. Has high activity with zinc; zinc cofactor is transferred into the active site region by the ZNG1 zinc chaperone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Associates with the 60S ribosomal subunit of the 80S translational complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="11"/>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH38237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JQE5"/>
    <dbReference type="STRING" id="742152.A0A2H3JQE5"/>
    <dbReference type="OMA" id="FYGDHAY"/>
    <dbReference type="OrthoDB" id="3209743at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004239">
        <property type="term" value="F:initiator methionyl aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01086">
        <property type="entry name" value="MetAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000010">
        <property type="entry name" value="Methionine aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01974">
        <property type="entry name" value="MetAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002467">
        <property type="entry name" value="Pept_M24A_MAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031615">
        <property type="entry name" value="Zfn-C6H2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00500">
        <property type="entry name" value="met_pdase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43330">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43330:SF7">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15801">
        <property type="entry name" value="zf-C6H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00680">
        <property type="entry name" value="MAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52013">
        <property type="entry name" value="ZF_C6H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9 11" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9 11" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C6H2-type" evidence="12">
        <location>
            <begin position="5"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>a protein</name>
            <dbReference type="ChEBI" id="CHEBI:16541"/>
        </ligand>
        <ligandPart>
            <name>N-terminal L-methionine residue</name>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>a protein</name>
            <dbReference type="ChEBI" id="CHEBI:16541"/>
        </ligand>
        <ligandPart>
            <name>N-terminal L-methionine residue</name>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="361"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="361"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PCH38237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="386" mass="42862" checksum="8667A2D845D18620" modified="2018-01-31" version="1">MSAAGIPCQSSICPNGHPPSRLECPTCNKLGIKGSFFCGQECFKAGSSFSLSAGKTHKLIHELATRQPLLEDPNINKNGTYNPFGNFNFTGTMRPAYPLSPRRPVPEHIPRPDYAEDGMPISENRRAGQPIKILTAEEQEKIRTVCRLAREVLDIAASHIQPGITTDELDEIVHNATIERNAYPSTLNYRNFPKSVCTSINEVICHGIPDKRRLQEGDIINIDVTLYYDGYHGDLNETYPVGRIDEDSKKLLRITRQSLDAAIALCKPGALFRDLGKAIEPIARANGCSVVRTYCGHGIHELFHCAPNIPHYAKNKAVGMMKPGMVFTIEPMINLGHWDLVHWPDDWTAATIDGKRSAQFEETLLITETGVEVLTAGKRRADLYDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JQF5</accession>
    <name>A0A2H3JQF5_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Actin-like ATPase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_105017</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468157">
        <property type="protein sequence ID" value="PCH44390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JQF5"/>
    <dbReference type="STRING" id="742152.A0A2H3JQF5"/>
    <dbReference type="OMA" id="CQIFFER"/>
    <dbReference type="OrthoDB" id="74201at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="41"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="58"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH44390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="516" mass="55782" checksum="B31D7670FD2BBFC2" modified="2018-01-31" version="1"> </sequence>
</entry>
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    <dbReference type="OrthoDB" id="312874at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="1">
        <location>
            <begin position="128"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH44612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="406" mass="46156" checksum="CADE55B975B22C44" modified="2018-01-31" version="1">MDAGVIDRVFLDVVYSSYTSSLLDSDEIVRRVWNGMPKFISPSAGPSMAAEVSLTAEASLNDETSITAWLNLLTSVIFAQLKASNSKLPKLRSDSEWTSEKANVPIRGITELKPDAILHIVTTGEPISDPDWTNILAFCEVTRSRKRDNIEDHLTCHAQFAFAHQPFRRFVPALAIIYKHFVLYIFDRFGVLYTEDYPFTPANKPLFLRIIYSLMFVPLDYLSIDLSTTYPTNGYSFGGPITVRVDESEYVIDNVGCNVFQSNCLQGRATSCWVVHEPGSDHKLLLKDSWCDKNRKPHEQAVYGVLKKAIKEHRAEKKPVPVAIPTIEKASIIFVDSMHRRFDDTEHVRKLHTMFEIPQETTIRQHIRLILQNVGYPLTDFEFRLELIEAIRDIVSSTRATLSIVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JRD8</accession>
    <name>A0A2H3JRD8_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF1014-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WOLCODRAFT_65554</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCDC124 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH38567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JRD8"/>
    <dbReference type="STRING" id="742152.A0A2H3JRD8"/>
    <dbReference type="OMA" id="ERETPNV"/>
    <dbReference type="OrthoDB" id="76412at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010422">
        <property type="entry name" value="Ccdc124/Oxs1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054414">
        <property type="entry name" value="Ccdc124/Oxs1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21680">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21680:SF0">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06244">
        <property type="entry name" value="Ccdc124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Coiled-coil" evidence="3">
        <location>
            <begin position="3"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PCH38567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="115" mass="13040" checksum="C478AF52AF2DA08F" modified="2018-01-31" version="1" fragment="single">SYAATGIDNALDLLEVVTAKMDKASVGQQAAGLEKHPERRFKAAFEAYKERELPNVRVEHPGLRLQQYHDLLYKQFQKSPENPFNQVTVAYDAKKEDKVGALKKKNAAIEERLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JRS1</accession>
    <name>A0A2H3JRS1_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MULE transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_50308</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468168">
        <property type="protein sequence ID" value="PCH44631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JRS1"/>
    <dbReference type="STRING" id="742152.A0A2H3JRS1"/>
    <dbReference type="OMA" id="TSEINAC"/>
    <dbReference type="OrthoDB" id="2437251at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018289">
        <property type="entry name" value="MULE_transposase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10551">
        <property type="entry name" value="MULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MULE transposase" evidence="1">
        <location>
            <begin position="146"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH44631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="425" mass="49611" checksum="1D13F7D3D5BA7A2A" modified="2018-01-31" version="1" fragment="single">RMDRFDCCGWLHIVLSCQPQEALIRLKHDEHIAYTDIELPDHWKEYIKDHARTQTPGEVKTHGKQVTDTGLPYRSKAVYYYWHVISKTEWRRADDPLESARRFIEENGDEYQVKLMDVKAALATKVLAFQVVDFVKEWAEHTQELAMDSTWNTNGANFEVFATVAEAQGSGIPLAFLLILTSPEAASGAKQDVLENFLGEVKKLGMDPEYTLTDKDWSEINAMHATWPNAKHQLCFWHALRALKQRLAKTKEHPAHYDVESACCEFSFIKNNFLPEMQRHRVFRSSKCRCTARIRYEEKRRLPVLSSLPIMHLFAKHASQHSLLPEQHGQPRTASEIRRDAVTEMYFHCERNHLPEVWAYLWTSWYSPSRWTLWARSANSRSIPCKWTTMMVEALWRNIKRLVLHMYNRPPVDLATYAIITKAIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JS61</accession>
    <name>A0A2H3JS61_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WOLCODRAFT_165541</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FMO family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468168">
        <property type="protein sequence ID" value="PCH44990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JS61"/>
    <dbReference type="STRING" id="742152.A0A2H3JS61"/>
    <dbReference type="OMA" id="GQFPMGD"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
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        <property type="match status" value="5"/>
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                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468011">
        <property type="protein sequence ID" value="PCH39577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JTY0"/>
    <dbReference type="OrthoDB" id="2758629at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="165"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="184"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH39577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="411" mass="44169" checksum="BBE2F69FADDAFC41" modified="2018-01-31" version="1">MDTLRDTGSLFSKSNPEGIKFPESAATSLVIRDYNVRRPIPGLGNVVPRLVGDSVQGVQVPEKVVVADRYPILIGHRSKASLFSRDAELSSVHIPVEQKTPSGDSKTTVDLSERDLAPQNAVQSTTRRTPSSDAIWAGECHRHDQALIVSEQRRLYRDVEEYLRSPSSTDSPCTPSLVGDIDSDSSSLCDSDQSVSEMSTDSVVDLAPSVSCHTRVSLVIEELKRRCETGDTGPLLSATVPDITLNGGEPALLYTDSPVPEFPDSFVGADNGEVEERLKHSDEATIAALSDLPNSSAVDFLQIPSMSWTAPKPDVDSESVVNISNVSGSAFVLCVPPRRGKFKIDKRYTDTLASGPADLGHGAGRGSGTGRPREYSLASRYDIPKTENAIKYSRVGRGRGIGLGIAPPGYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JU36</accession>
    <name>A0A2H3JU36_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sister chromatid cohesion protein Dcc1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_121994</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DCC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468146">
        <property type="protein sequence ID" value="PCH43473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JU36"/>
    <dbReference type="STRING" id="742152.A0A2H3JU36"/>
    <dbReference type="OMA" id="DSESWPF"/>
    <dbReference type="OrthoDB" id="276989at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034088">
        <property type="term" value="P:maintenance of mitotic sister chromatid cohesion"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019128">
        <property type="entry name" value="Dcc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13395:SF6">
        <property type="entry name" value="SISTER CHROMATID COHESION PROTEIN DCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13395">
        <property type="entry name" value="SISTER CHROMATID COHESION PROTEIN DCC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09724">
        <property type="entry name" value="Dcc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH43473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="374" mass="41433" checksum="EB9A6E7A5EBAE18A" modified="2018-01-31" version="1">MADLSLKFSSSTALDTGSFRLLELPSDLSKAVESALLSIKGDPDEDAVLCTGDKTYTLRSIVLSNSVLVVTPSQEDDGNSSDVVIRDQIHEVLELVSSVPRLHKLDSLLRGREYEEGRDEEEDIEMADMGENRSSQHVRLSYVDARNVLQTSDSELDRYLRDRRVLDLDGELRPIVPSYLTTILELILTNLVSLSLSHDAVPADTLESALEGGHDVRRDVARQVMGWFGILANGMWKMDAQAIVREVGLGILRPHRDDPIAQDAFLARWRTAVGDTFAAHVSLALLAGNYLSSTDSTRDPPLTTLTYLPCSQLPTDPAARFGDLFRARARWRAEEIAPFLADVAVDAKERDRLLLKYTRAVPGEGGVWYSARGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JUA5</accession>
    <name>A0A2H3JUA5_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_145350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468168">
        <property type="protein sequence ID" value="PCH45145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JUA5"/>
    <dbReference type="OrthoDB" id="2803682at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH45145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="199" mass="23105" checksum="10BBDECF47F3ADAA" modified="2018-01-31" version="1">MAFLQVPNPFMELHHMPDYNHSLTGPQYYLQNFDASDRDDRDFALFAVHNRRARRPQNLEKWPTHTLFAFVYGVVAMHAFPPGPLSECVHILRWNWGSRFYSSAVGNNRDGELSSISAQREALAERKREQDDARAARRANRIVQEVDEAAIVVAMIREIIDRDNEASTEELKRQAEQRRHEQAREKVADWLAGVQPHSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JV02</accession>
    <name>A0A2H3JV02_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Nep1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WOLCODRAFT_69591</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH41678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <source>
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        </source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PCH41678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="237" mass="25782" checksum="AF0B371387B64CF0" modified="2018-01-31" version="1">MLPVQAHVSRGGPASSQRRLFVILEQACLEAYRVSSNGKGKNGREGDVKYALLNCDDHQGILAKTGRDIADARPDITHQCLLTLLDSPLNKAGLLQVYIHTAKGVLIEVNPHVRIPRTFKRFSGLMVQLLHKLSIRGVNGPEKLLKVIKNPVTDHLPANTIKLTLSGDAPTVRLSKYLPTLPETHSIAVFVGAMARGKDDFADGVVDEKIGISDYPLSASVACGKFCCALEELWDIV</sequence>
</entry>
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    <accession>A0A2H3JVB0</accession>
    <name>A0A2H3JVB0_WOLCO</name>
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        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
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                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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        </location>
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        </location>
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        </location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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            <end position="342"/>
        </location>
    </feature>
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        <location>
            <begin position="344"/>
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        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH40654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
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</entry>
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        <lineage>
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        </lineage>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
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                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
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                <person name="Sabat G."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD-104</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="742152.A0A2H3JVI0"/>
    <dbReference type="OMA" id="PSEWDDA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051414">
        <property type="entry name" value="Adenylate-forming_Reductase"/>
    </dbReference>
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        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439:SF2">
        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439">
        <property type="entry name" value="PHENYLACETATE-COENZYME A LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
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    </dbReference>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
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    </dbReference>
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            <begin position="1"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="731"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PCH43993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="731" mass="81834" checksum="A0C0C693094B35E9" modified="2018-01-31" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JVW0</accession>
    <name>A0A2H3JVW0_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PR-1-like protein</fullName>
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    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_46007</name>
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        <name type="common">Brown rot fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
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                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
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                <person name="Spatafora J.W."/>
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                <person name="Benoit I."/>
                <person name="Boyd A."/>
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                <person name="Coutinho P.M."/>
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                <person name="Ferreira P."/>
                <person name="Findley K."/>
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                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
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                <person name="Kumar T.K.A."/>
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</entry>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
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                <person name="Binder M."/>
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                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
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                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
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                <person name="Benoit I."/>
                <person name="Boyd A."/>
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                <person name="Tsang A."/>
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                <person name="Young D."/>
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                <person name="Martin F."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="60"/>
            <end position="80"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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    <sequence length="545" mass="59333" checksum="CA119D173C379941" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JWH5</accession>
    <name>A0A2H3JWH5_WOLCO</name>
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        <submittedName>
            <fullName evidence="14">Pkinase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">WOLCODRAFT_138939</name>
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    <organism evidence="14 15">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
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            <dbReference type="DOI" id="10.1126/science.1221748"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="14 15">MD-104</strain>
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        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.</text>
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        <location>
            <begin position="960"/>
            <end position="969"/>
        </location>
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        <location>
            <begin position="1054"/>
            <end position="1063"/>
        </location>
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        <location>
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        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
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            <end position="1621"/>
        </location>
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        <location>
            <begin position="1677"/>
            <end position="1688"/>
        </location>
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        <location>
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            <end position="1698"/>
        </location>
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        <location>
            <begin position="1699"/>
            <end position="1709"/>
        </location>
    </feature>
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        <location>
            <begin position="1710"/>
            <end position="1732"/>
        </location>
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        <location>
            <begin position="1749"/>
            <end position="1761"/>
        </location>
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        <location>
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            <end position="1784"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="1218"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PCH44333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="1793" mass="194394" checksum="4344189EB567B552" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JWL9</accession>
    <name>A0A2H3JWL9_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">LuxS/MPP-like metallohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WOLCODRAFT_136929</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="11 12">MD-104</strain>
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        <text evidence="1">Belongs to the peptidase M16 family.</text>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Insulin-degrading enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="nardilysin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Peptidase_M16"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="INSULIN-DEGRADING ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
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    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
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        <location>
            <begin position="44"/>
            <end position="179"/>
        </location>
    </feature>
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            <end position="406"/>
        </location>
    </feature>
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        <location>
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            <end position="700"/>
        </location>
    </feature>
    <feature type="domain" description="Coenzyme PQQ synthesis protein F-like C-terminal lobe" evidence="10">
        <location>
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        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF22456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PCH40557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="1006" mass="113930" checksum="F1C2DFD84F6AFD79" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JWN1</accession>
    <name>A0A2H3JWN1_WOLCO</name>
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        <submittedName>
            <fullName evidence="5">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WOLCODRAFT_138291</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468135">
        <property type="protein sequence ID" value="PCH43309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="742152.A0A2H3JWN1"/>
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    </dbReference>
    <dbReference type="CDD" id="cd00200">
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        <property type="match status" value="1"/>
    </dbReference>
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    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
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    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF8">
        <property type="entry name" value="F-BOX AND WD REPEAT DOMAIN CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
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    <dbReference type="PRINTS" id="PR00320">
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                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD-104</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
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        <property type="protein sequence ID" value="PCH42134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="742152.A0A2H3JZG3"/>
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    <dbReference type="OrthoDB" id="691673at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901605">
        <property type="term" value="P:alpha-amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050859">
        <property type="entry name" value="Class-I_PLP-dep_aminotransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790:SF19">
        <property type="entry name" value="KYNURENINE_ALPHA-AMINOADIPATE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
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        <location>
            <begin position="83"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PCH42134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="441" mass="48492" checksum="D19007999660BD8E" modified="2018-01-31" version="1">MVKALPPEFYAPFLSDLAKERKPSPIRGLYPLEARPGVISLLAGKPNATTFPLTSVTLTSRSPIDPTHEITTKVHGQALADGLQYGPTAGLPALCEWVYGLQEREHGRKKGEGWRVSIGAGSQDVIFKAVMAMVNTGDSVLVECPVYAGVLPMFQSLHCDLIEVETDSQGIRSSSLRSILENWPELKPKPKVLYTVPYGCNPTGMTATLDRRQEVLALAREHNFIILEDDPYYYLYYGDSPRHPSYFALELEQPEVGRVLRFDSLSKILSSGIRIGFACGPEPLLAAIDMHTAVANLQTPSLTQTLTFALLDAWGYAGFAAHTAAVSSFYRAKRDVFAGALRRHLTGLAEWTDPEAGMFFWFKLLLGSDDGNGEEGDSESIIRTKAYERGVLALPGTVFLPRGGKTAYVRAAFSLLDEDQVEEAVKRLKETILEARQSAHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JZS6</accession>
    <name>A0A2H3JZS6_WOLCO</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_138990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
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        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="PCH44409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JZS6"/>
    <dbReference type="OMA" id="LDDEVCH"/>
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    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH44409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="284" mass="29970" checksum="2191AB142C2D9A37" modified="2018-01-31" version="1">MDAMDVNWCLTCQRHIDVEGSAPYCSRECYASDRPSSSSLSPHFRPLEYDAYAESISELDGCEACSQSRDNDACTEQSRWIGKGMAGIHAWAQNVPPGPPAAEVVSVADLRPPVLLQQARRPVPPSVCVTQSVSAAPEPAQPPHEPVPALSRSSRCPTDASALTTPCSSVSLATPASNACAFPISAQAGLISTLTAQLRSWAAASHKGSPRSHTITRPADAPAPCVVLPADGASDGASCYSDVKESYGHPEKFAPAAADCWEALLSDDRPGLRMRGRRSARCVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K121</accession>
    <name>A0A2H3K121_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
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    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_152754</name>
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    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
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                <person name="Sun S."/>
                <person name="Syed K."/>
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                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K121"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH42714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="144" mass="17237" checksum="17DDE8F4096C195E" modified="2018-01-31" version="1">MLEVPLDNVEKQLARQIFGDDVFNIDEQCEWMKKDIHAFVHAELVKDNYKNMWRMIKECKEALAKISEDPNMTQPRRHLMQLLKSVCQLVPLMKWYKKLESEVTCMEWEKLLKNMLSKSEADRSQLPRQLRIMLEQLPDQQMVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K251</accession>
    <name>A0A2H3K251_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">G-protein alpha subunit</fullName>
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    <gene>
        <name evidence="8" type="ORF">WOLCODRAFT_73479</name>
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    <organism evidence="8 9">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468124">
        <property type="protein sequence ID" value="PCH42467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K251"/>
    <dbReference type="STRING" id="742152.A0A2H3K251"/>
    <dbReference type="OMA" id="WRTVIYF"/>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007188">
        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000692">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF360">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0807">Transducer</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="139"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="305"/>
            <end position="311"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="403"/>
            <end position="406"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PCH42467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="492" mass="55188" checksum="345D9D4BB51D4B49" modified="2018-01-31" version="1">MISTSRPPSVHSTTTDAGDPLSALLRPPPSESETDKALRLQREAEAKKINDKIDEEIKADRERYKKSKQDVKLLLLGQAESGKSTLQKQFQLMYNPTSLEEERLSWRVVIYYNIVRPILRILEVLDAYAELEDDEEAATSLAQGADAAPPRLSPSPSPSADQGLATLRLRLSPLQALEGSLAHRLNGGVAVSGSGKGSVFVRSGWQARAFGLAFGKGRERTVSARGRFSFTGQRSSLENGDKLVEDTANVLSLCKDDARELWGHPMVKRLRESRKLRLEEWAEYFLNNIERVSSPGYVPTIDDILHARIQTMGVAEHIFDVPLHGRNVTWHLYDVGGARGQRHTWVPYFDDATAIIFLAPVSAFDQYLTEDPRTNRVDDSLQLFKQICSNQLLKGAHLVLFLNKADVLREKLERGVKVKRYITSYGDRPNEADAVVSYFKAHFAQVHTKNNESKRVLYTHLTSVVDTKAMQSIISNVRDSIFRDYLKSAALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K281</accession>
    <name>A0A2H3K281_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WOLCODRAFT_102265</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB468124">
        <property type="protein sequence ID" value="PCH42507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K281"/>
    <dbReference type="STRING" id="742152.A0A2H3K281"/>
    <dbReference type="OMA" id="IASCMNE"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05227">
        <property type="entry name" value="AR_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF564">
        <property type="entry name" value="STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="9"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PCH42507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="348" mass="38427" checksum="C8C4A32C069248F6" modified="2018-01-31" version="1">MPAVASGKVLVTGANGYVAVWVVRRLLEKGYSVRATVRAESKGTHLRKIFAEYGDKLEIVVVADITKPGAFDEAVKGVDAVEHTASPFHFNAKDPAEIVTPAVNGTLRALEAVLAHGTSVKRVVVTSSCAAVLSVLPEPHVFNESDWNDQSVDLINQQGADADQVVKYLASKTLAERAAWEFLEKNKGKINWDLVVINPPYVYGPAIHEVESPEALNESLNAWYRSVFKNLHEPAQASSIGYGFLADWIDVRDVADAHYLALQKEQAANQRIIISAGNWKWQDWINTARKFGVETSKGDDSYDPTVAVHMIQYDVSRAKAVLGINKYYSIEETTKDTIDDFKARGWIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K2A1</accession>
    <name>A0A2H3K2A1_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_165026</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468157">
        <property type="protein sequence ID" value="PCH44268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="742152.A0A2H3K2A1"/>
    <dbReference type="OMA" id="QNAWSET"/>
    <dbReference type="OrthoDB" id="3262497at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="224"/>
        </location>
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            <end position="303"/>
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            <begin position="304"/>
            <end position="320"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH44268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="1323" mass="139291" checksum="5F270BA8D711B174" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K3H3</accession>
    <name>A0A2H3K3H3_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">adenosine deaminase</fullName>
            <ecNumber evidence="4">3.5.4.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WOLCODRAFT_139151</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>adenosine + H2O + H(+) = inosine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:24408"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. ADGF subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.4" evidence="4"/>
    <dbReference type="EMBL" id="KB468168">
        <property type="protein sequence ID" value="PCH44698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OMA" id="SMKQCIE"/>
    <dbReference type="OrthoDB" id="7202371at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004000">
        <property type="term" value="F:adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006154">
        <property type="term" value="P:adenosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046103">
        <property type="term" value="P:inosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000017">
        <property type="entry name" value="Adenosine deaminase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001365">
        <property type="entry name" value="A_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409">
        <property type="entry name" value="ADENOSINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409:SF39">
        <property type="entry name" value="ADENOSINE DEAMINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00962">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Adenosine deaminase" evidence="10">
        <location>
            <begin position="213"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PCH44698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="540" mass="60919" checksum="010BA593DF7FD42B" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K3Y2</accession>
    <name>A0A2H3K3Y2_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WOLCODRAFT_104108</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468146">
        <property type="protein sequence ID" value="PCH43754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K3Y2"/>
    <dbReference type="STRING" id="742152.A0A2H3K3Y2"/>
    <dbReference type="OMA" id="FLFFGSQ"/>
    <dbReference type="OrthoDB" id="28208at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF458">
        <property type="entry name" value="SODIUM-COUPLED NEUTRAL AMINO ACID TRANSPORTER 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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                <person name="Barry K."/>
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                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM135 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH33641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3IV91"/>
    <dbReference type="OMA" id="CFFYEPE"/>
    <dbReference type="OrthoDB" id="4021778at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026749">
        <property type="entry name" value="Tmem135"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031926">
        <property type="entry name" value="TMEM135_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12459:SF15">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12459">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 135-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15982">
        <property type="entry name" value="TMEM135_C_rich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="398"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="Transmembrane protein 135 N-terminal" evidence="8">
        <location>
            <begin position="353"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="544"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="551"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF15982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PCH33641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="570" mass="62540" checksum="A0E0A490FFD88169" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IV93</accession>
    <name>A0A2H3IV93_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">chitin deacetylase</fullName>
            <ecNumber evidence="20">3.5.1.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">WOLCODRAFT_86713</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + n H2O = chitosan + n acetate</text>
            <dbReference type="Rhea" id="RHEA:10464"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9597"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57704"/>
            <dbReference type="EC" id="3.5.1.41"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:10465"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the polysaccharide deacetylase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.41" evidence="20"/>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH33355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3IV93"/>
    <dbReference type="STRING" id="742152.A0A2H3IV93"/>
    <dbReference type="OMA" id="YMSGHQI"/>
    <dbReference type="OrthoDB" id="407355at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004099">
        <property type="term" value="F:chitin deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.370:FF:000004">
        <property type="entry name" value="Related to Chitin deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050248">
        <property type="entry name" value="Polysacc_deacetylase_ArnD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587:SF133">
        <property type="entry name" value="CHITIN DEACETYLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587">
        <property type="entry name" value="GLYCOSYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0134">Cell wall</keyword>
    <keyword evidence="18" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="12" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="16" id="KW-0170">Cobalt</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="17" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <keyword evidence="10 22" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="22">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013742884" description="chitin deacetylase" evidence="22">
        <location>
            <begin position="18"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="23">
        <location>
            <begin position="184"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00024056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="PCH33355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="475" mass="50171" checksum="A2049ADB7BEDF6CB" modified="2018-01-31" version="1">MWFALATAVTLPALASAHGVHGVQHHARASDIADAVASATAAVASGASALPSLTFSLASVNPTALPLSSIVATAPTQATIALSSTYVAGSKPTNIPGAPGMPAAYTINPKDYPTLDKTPPTDTDLVQQWIQEVQDSGISIPDIPVTNLGGCANNTEAAANTSRCWWTCGGCTRDTDISTCPTKNTWGLTYDDGPGPWTPDLLQYLEQHDMHSTFFVIGSRAISRPAMLQDEYMAGHQIAVHTWSHPYMTTKTNEEVIAELGWTKKVIKDTIGVTPLYWRPPYGDIDDRVRAISRAMNLIPIMWTRMDAEQTFDTQDYDIPAGEVTSTQVLNNWQEIMNNSSSIDTGFIVLEHDLWQQTVDIAVGYILPEALAHQPKFNITPVIECQDMPLSNSYIETNDNSTNPPPVLDYKASASGSASVSVSASASAAQGSSTSGVSVNSAAGASSGAPAMAVVSQGMVTAALSAIAAAGAFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IXF2</accession>
    <name>A0A2H3IXF2_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Extracellular metalloproteinase</fullName>
            <ecNumber evidence="13">3.4.24.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Fungalysin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">WOLCODRAFT_27343</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">MD-104</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the peptidase M36 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="13"/>
    <dbReference type="EMBL" id="KB467832">
        <property type="protein sequence ID" value="PCH34636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3IXF2"/>
    <dbReference type="STRING" id="742152.A0A2H3IXF2"/>
    <dbReference type="OMA" id="IRKDSYT"/>
    <dbReference type="OrthoDB" id="3227768at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09596">
        <property type="entry name" value="M36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011096">
        <property type="entry name" value="FTP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050371">
        <property type="entry name" value="Fungal_virulence_M36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001842">
        <property type="entry name" value="Peptidase_M36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33478">
        <property type="entry name" value="EXTRACELLULAR METALLOPROTEINASE MEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33478:SF1">
        <property type="entry name" value="EXTRACELLULAR METALLOPROTEINASE MEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07504">
        <property type="entry name" value="FTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02128">
        <property type="entry name" value="Peptidase_M36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 13" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 13" id="KW-0732">Signal</keyword>
    <keyword evidence="8 12 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 13" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013426238" description="Extracellular metalloproteinase" evidence="13">
        <location>
            <begin position="20"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="domain" description="FTP" evidence="14">
        <location>
            <begin position="84"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="582"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="353"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="581"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="585"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="611"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601842-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601842-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU364017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF07504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PCH34636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="821" mass="90687" checksum="2C3ACB07A1D0FFC4" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IXF6</accession>
    <name>A0A2H3IXF6_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">USP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_113208</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH34125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3IXF6"/>
    <dbReference type="STRING" id="742152.A0A2H3IXF6"/>
    <dbReference type="OMA" id="WAMVPSN"/>
    <dbReference type="OrthoDB" id="443682at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055335">
        <property type="entry name" value="Ucp6/RUP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39597">
        <property type="entry name" value="UBA DOMAIN-CONTAINING PROTEIN RUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39597:SF1">
        <property type="entry name" value="UBA DOMAIN-CONTAINING PROTEIN RUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="43"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="613"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="456"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="632"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="648"/>
            <end position="658"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH34125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="658" mass="72989" checksum="34E27255EC173C2B" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IXL5</accession>
    <name>A0A2H3IXL5_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Septin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WOLCODRAFT_27402</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467832">
        <property type="protein sequence ID" value="PCH34706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3IXL5"/>
    <dbReference type="STRING" id="742152.A0A2H3IXL5"/>
    <dbReference type="OMA" id="EASHAEI"/>
    <dbReference type="OrthoDB" id="416553at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032156">
        <property type="term" value="C:septin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000238">
        <property type="entry name" value="Cell division control 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006698">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="5">
        <location>
            <begin position="28"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="295"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PCH34706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="385" mass="44509" checksum="CDEF4B8A5D129722" modified="2018-01-31" version="1">MAAAAPPMSDGIGIANLPNQRHKIVAKRGAHFTVMVVGESGLGKTTLINTLFSTELSPAKNYNRRHHKQLDKLTEVEIIKAELEEKQFKTKLTVIDTPGFGDYVNNRDSWTPIVDFIDDQHEAYMRQEQQPQRKDKIDLRVHACLYFIRPTGHTLKPLDIEIMKRLGTRVNLIPVIAKADTLTQNDLFTFKQRIRDVINAQGIRIYQPPIEPDDEASAEHARILTDSMPFSIIGSTEDVKTADGRVVKGREYLWGVAEVENENHCDFRKLRSLLIRTHMLDLISTTEELHYENYRQGQMESRKPGESKPRKFENPKFKEEEEQLRKRFTEQVKAEEARFRQWEQHLIQERDRLNKDLEFAHSAIKALEAELDNLQVGYGRGTGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IXV7</accession>
    <name>A0A2H3IXV7_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_139601</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467832">
        <property type="protein sequence ID" value="PCH34830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3IXV7"/>
    <dbReference type="OMA" id="RANDEMY"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="236"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH34830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="471" mass="53179" checksum="79BA0A83AF2E45C3" modified="2018-01-31" version="1">MDEAITSELRPLIKRYRQSFRGKAPSPSIAAQPREYYNFQNGVSPILDGRYASVAAPIVIYDPVFATFIANVNSSEPVDDDDLVRQTEKFMESVSEIRCAENESYTSNRVGLQRILEAALESMATHTDGPESDHIIPYIREVGPREAAALGIIEEKAEVDKSGDAAVQAEFYYRLYWSNTQDLLDESFSSTFLVGLMGPYLSISGAIWTTDIVVQPLVSGLLWLGSPPLISDVEIIRVARVFGALKKGLKSLRDRYRHLNPPAGNILRRFFPLATSFTYSGKEVSFKYQKYLKSKSASCLVFSATLDKEVIGDEQQVVVKFVERYGKDAHELLAKEGLAPKLYYCGDIWHNDPVANKGCGSRKMIVMEYVQGRSATRTDCINHHERLSKAVKLLHDKGMVHGDLRRPNIIVTDNPDGPLKMIDFDWAGMQGEVRYPLRLSKEIYWEPSVRDYALIEYKHDDFMLRRLIAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IZA0</accession>
    <name>A0A2H3IZA0_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">WOLCODRAFT_156015</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SEC23/SEC24 family. SEC24 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB467843">
        <property type="protein sequence ID" value="PCH35320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3IZA0"/>
    <dbReference type="STRING" id="742152.A0A2H3IZA0"/>
    <dbReference type="OrthoDB" id="49016at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01479">
        <property type="entry name" value="Sec24-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1670">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.730">
        <property type="entry name" value="Sec23/Sec24 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012990">
        <property type="entry name" value="Beta-sandwich_Sec23_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006900">
        <property type="entry name" value="Sec23/24_helical_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036175">
        <property type="entry name" value="Sec23/24_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006896">
        <property type="entry name" value="Sec23/24_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050550">
        <property type="entry name" value="SEC23_SEC24_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041742">
        <property type="entry name" value="Sec24-like_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006895">
        <property type="entry name" value="Znf_Sec23_Sec24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803">
        <property type="entry name" value="SEC24-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803:SF39">
        <property type="entry name" value="SECRETORY 24AB, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08033">
        <property type="entry name" value="Sec23_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04815">
        <property type="entry name" value="Sec23_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04811">
        <property type="entry name" value="Sec23_trunk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04810">
        <property type="entry name" value="zf-Sec23_Sec24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81811">
        <property type="entry name" value="Helical domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="WW" evidence="13">
        <location>
            <begin position="6"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PCH35320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="935" mass="101995" checksum="CEDAA17DABF8BD44" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IZI0</accession>
    <name>A0A2H3IZI0_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GST C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WOLCODRAFT_139753</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467843">
        <property type="protein sequence ID" value="PCH35131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3IZI0"/>
    <dbReference type="STRING" id="742152.A0A2H3IZI0"/>
    <dbReference type="OMA" id="VSYGCPW"/>
    <dbReference type="OrthoDB" id="2309723at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03190">
        <property type="entry name" value="GST_C_Omega_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000162">
        <property type="entry name" value="Glutathione S-transferase Gst3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047047">
        <property type="entry name" value="GST_Omega-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016639">
        <property type="entry name" value="GST_Omega/GSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32419:SF6">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE OMEGA-LIKE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32419">
        <property type="entry name" value="GLUTATHIONYL-HYDROQUINONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13410">
        <property type="entry name" value="GST_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015753">
        <property type="entry name" value="GST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01206">
        <property type="entry name" value="Xi.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01148">
        <property type="entry name" value="Xi_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST C-terminal" evidence="4">
        <location>
            <begin position="161"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="47"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>glutathione</name>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="116"/>
            <end position="119"/>
        </location>
        <ligand>
            <name>glutathione</name>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="134"/>
            <end position="135"/>
        </location>
        <ligand>
            <name>glutathione</name>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Cys" evidence="3">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <feature type="site" description="Lowers pKa of active site Cys" evidence="3">
        <location>
            <position position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR015753-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR015753-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR015753-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PCH35131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="311" mass="35996" checksum="D5F4552085B535BD" modified="2018-01-31" version="1">MVQETVKNNDQDGSFKRKASSFRDFIQKGGRFEPEKGRYLLYVSYACPWATRTLIMRHLKGLEDIIDVSIVSPRMGENGWPFATVDPFPKATADPLYNSSHVKELYFRADPDYGGRFSVPVLWDKKTHTIVNNESSEIIRILNSAFNEFLPAEKAALDFYPEKLRQEIDEINEWVYDTVNNGVYRAGFATTQQAYEAAVLPLFASLDRLEKILTGKDFLVGDQLTEADVRLFVTLIRFDPVYHGIFKCNIRSIRGDYPALNLWMRKLYWTHPSFNETCDFDHIKESYYWSRPSMNPYRIVPVGPVPHILPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IZZ3</accession>
    <name>A0A2H3IZZ3_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Multidrug resistance-associated ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WOLCODRAFT_125974</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
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                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH33473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J118"/>
    <dbReference type="STRING" id="742152.A0A2H3J118"/>
    <dbReference type="OMA" id="WGVPAEM"/>
    <dbReference type="OrthoDB" id="10054765at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13365">
        <property type="entry name" value="Trypsin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH33473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="383" mass="40379" checksum="2A2CD7735A82059C" modified="2018-01-31" version="1">MALRQTALASRSRITSSLSSAACLNSPSARAYATVGTTTYIGQPPPPPTPPPAASSSSTTAANLSSVFDAQILYELRRRCQLAPGSSTGSQVQLPKLVEQYLDRGGLVLDSSLPYESRPGKDRRIDVDESAALDSVAMIVHAAQQGAEHKITHCSGFALSAPGLSEGQSVMVTCAHTLEEIRHSPILRRDAPPNANNAALPSVSGSFVITGPSSSPTFSPVSSILSSLHRSDLLLMSAPPSPFPALRTLPVSPYPAQPGARIRAHFVTHKEPVPGAGAEGWRPWVGGTWSKWIRGTVLGYRDMAGREAKPGTYDALSHLLFDPTPTPGSSGGPIIDEESGAVIGVVLGTQMQNRLQGVCGWGVPSEMIFEMFSLPGLKLNNRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J1B2</accession>
    <name>A0A2H3J1B2_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Lectin 1a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_81600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467865">
        <property type="protein sequence ID" value="PCH36032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J1B2"/>
    <dbReference type="STRING" id="742152.A0A2H3J1B2"/>
    <dbReference type="OMA" id="KACWHYT"/>
    <dbReference type="OrthoDB" id="2794201at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.270.20">
        <property type="entry name" value="Cytolysin/lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015926">
        <property type="entry name" value="Cytolysin/lectin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009960">
        <property type="entry name" value="Fruit_body_lectin_fun"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07367">
        <property type="entry name" value="FB_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63724">
        <property type="entry name" value="Cytolysin/lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH36032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="141" mass="15487" checksum="1B77A494341FAE12" modified="2018-01-31" version="1">MSYTIVVRVIDASDVGFSLVEKTVWYYANGGTWSNTNGIQTLVMGGSGTSGTLRFKSGDGEAFLVAVGVHNYKHWCDVAVDLTDGDTSMKVQPTYYESTDRAKVREEQLSEITRKNSKGRSISVKYVTQDSNTFHAIVTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J2K1</accession>
    <name>A0A2H3J2K1_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Creatinase/aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WOLCODRAFT_81514</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD-104</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M24B family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467865">
        <property type="protein sequence ID" value="PCH35935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J2K1"/>
    <dbReference type="STRING" id="742152.A0A2H3J2K1"/>
    <dbReference type="OMA" id="LTHFRYT"/>
    <dbReference type="OrthoDB" id="9995434at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01085">
        <property type="entry name" value="APP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.350.10:FF:000003">
        <property type="entry name" value="Xaa-pro aminopeptidase P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000007">
        <property type="entry name" value="Xaa-Pro aminopeptidase P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000587">
        <property type="entry name" value="Creatinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033740">
        <property type="entry name" value="Pept_M24B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032416">
        <property type="entry name" value="Peptidase_M24_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050422">
        <property type="entry name" value="X-Pro_aminopeptidase_P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43763:SF17">
        <property type="entry name" value="AMINOPEPTIDASE P, CYTOPLASMIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43763">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01321">
        <property type="entry name" value="Creatinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16189">
        <property type="entry name" value="Creatinase_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16188">
        <property type="entry name" value="Peptidase_M24_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Creatinase N-terminal" evidence="8">
        <location>
            <begin position="70"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M24" evidence="7">
        <location>
            <begin position="375"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M24 C-terminal" evidence="9">
        <location>
            <begin position="600"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PCH35935.1"/>
        </source>
    </evidence>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
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                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
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                <person name="Nagy L.G."/>
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                <person name="Sabat G."/>
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                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
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            <dbReference type="DOI" id="10.1126/science.1221748"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </location>
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</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
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                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
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            <strain evidence="1 2">MD-104</strain>
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                <person name="Yadav J.S."/>
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                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
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                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
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                <person name="Patyshakuliyeva A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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        </source>
    </evidence>
    <sequence length="121" mass="13447" checksum="BC0A3292CD2CB36D" modified="2018-01-31" version="1">MSVLLVLSREVFGTVAQCLSWQVSCHAELSHSSAACPCNLITALHASTDDHLHPTCARLRPFHRTHRASCPCALSLITGASLQRTLFGVALLVCVWIMWITVQGAVRMHRQRLIWGERLMS</sequence>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
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                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
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                <person name="Gaskell J."/>
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                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
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                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
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                <person name="Kuees U."/>
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                <person name="Kuo A."/>
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                <person name="Morin E."/>
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                <person name="Nagy L.G."/>
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                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
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                <person name="Pisabarro A."/>
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                <person name="Cullen D."/>
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        </citation>
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        </source>
    </evidence>
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    </evidence>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Barry K."/>
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                <person name="Otillar R."/>
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                <person name="Yadav J.S."/>
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                <person name="Benoit I."/>
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                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
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                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
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                <person name="Rokas A."/>
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                <person name="Stenlid J."/>
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                <person name="Wiebenga A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
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                <person name="Nolan M."/>
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                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
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        <source>
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    </evidence>
    <sequence length="555" mass="60827" checksum="D24DAEB378D3A371" modified="2018-01-31" version="1"> </sequence>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Barry K."/>
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                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="PCH37075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J5X4"/>
    <dbReference type="OrthoDB" id="2505969at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH37075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="123" mass="14345" checksum="E3CA68F501683A1F" modified="2018-01-31" version="1">MDIEGAELVKVFSEAVGNNDNEWETIPEDLHSNEDFMHALRDITHLSNNSLKHLALFDNRMQGDIRIFEESNYFLAQDFVDQYTNEVQSRKCKPNDSWAEYAEEEEGNNAEECHKKSDLPFFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J5Z1</accession>
    <name>A0A2H3J5Z1_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Coq4-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_167443</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467920">
        <property type="protein sequence ID" value="PCH37361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="742152.A0A2H3J5Z1"/>
    <dbReference type="OMA" id="QRYRECY"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007715">
        <property type="entry name" value="Coq4"/>
    </dbReference>
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        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12922:SF7">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS PROTEIN COQ4 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05019">
        <property type="entry name" value="Coq4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH37361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="166" mass="18572" checksum="62719E15F7482AE7" modified="2018-01-31" version="1">MSVFAAVTRSTTRPALRACAAASNTCLRPVQTRSASTQPAYEGHIPLNWFEPGFLTVGSAVMSLVDPRRGAALGDVASGPVLPRLRDFMLESPEGRKIFKQRPCLALLPQGTFRRAYVTWLEHCGVTLDTREPVHYVDDPELGYVLQRYRECYDFYHCMCGLPLHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J684</accession>
    <name>A0A2H3J684_WOLCO</name>
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        <submittedName>
            <fullName evidence="16">Acyl-CoA dehydrogenase NM domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">WOLCODRAFT_64995</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">MD-104</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 11 12">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH37726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J684"/>
    <dbReference type="STRING" id="742152.A0A2H3J684"/>
    <dbReference type="OMA" id="CFITNSG"/>
    <dbReference type="OrthoDB" id="9988775at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008470">
        <property type="term" value="F:3-methylbutanoyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006552">
        <property type="term" value="P:L-leucine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01156">
        <property type="entry name" value="IVD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000007">
        <property type="entry name" value="Isovaleryl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000003">
        <property type="entry name" value="isovaleryl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000004">
        <property type="entry name" value="Isovaleryl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034183">
        <property type="entry name" value="IVD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884:SF18">
        <property type="entry name" value="ISOVALERYL-COENZYME A DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016578">
        <property type="entry name" value="HsaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11 12" id="KW-0274">FAD</keyword>
    <keyword evidence="4 12" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="15">
        <location>
            <begin position="45"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="14">
        <location>
            <begin position="162"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="13">
        <location>
            <begin position="268"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="281"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="195"/>
            <end position="197"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="217"/>
            <end position="218"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="279"/>
            <end position="282"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="375"/>
            <end position="379"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="402"/>
            <end position="403"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="404"/>
            <end position="406"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR634183-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR634183-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR634183-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PCH37726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="425" mass="46462" checksum="C1E629393171FC30" modified="2018-01-31" version="1">MSRQVISSSLRLLSRPTCRAPRTMRPLFLQSRNASFYNADVAGLTEEQAEFRDAVTEFAQKEVAPRAAEIDKSNNFPKDLWEKLGSMGLLGITVSQEYGGLSLGYFNHTLAMEELSRASGSVALSYGAHSNLCVNQIHRWGTDAQKTKYLPDLVSGKKVGSLAMSEPGSGSDVVSMKLRADKVEGGYKLNGNKFWITNGPTASTLVVYAKTEPEKASRGITAFIIERGFAGFSTHQKLDKLGMRGSDTCELVFEDCLVPEENVLGKVNGGVEVLMSGLDLERLVLCGGPLGLMQSAFDTAVEYVHDRKQFGQPVGSFQLIQGKIADMYTKLNASRAYVYAVAKACDAGKVSRRDCAGAILYSSDRAVEVALDAMQCLGGNGYINDYPTGRFLRDARLYTVGAGTQEIRRMLIGREFNDEFRRRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J6E1</accession>
    <name>A0A2H3J6E1_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">UDP-glucose 4-epimerase</fullName>
            <ecNumber evidence="11">5.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WOLCODRAFT_22596</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>UDP-alpha-D-glucose = UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:22168"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="5.1.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 11">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate metabolism; hexose metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">In the C-terminal section; belongs to the aldose epimerase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the N-terminal section; belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.2" evidence="11"/>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH34309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J6E1"/>
    <dbReference type="STRING" id="742152.A0A2H3J6E1"/>
    <dbReference type="OMA" id="GEHLICN"/>
    <dbReference type="OrthoDB" id="9402762at2759"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003978">
        <property type="term" value="F:UDP-glucose 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05247">
        <property type="entry name" value="UDP_G4E_1_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005886">
        <property type="entry name" value="UDP_G4E"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01179">
        <property type="entry name" value="galE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43725">
        <property type="entry name" value="UDP-GLUCOSE 4-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43725:SF47">
        <property type="entry name" value="UDP-GLUCOSE 4-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01713">
        <property type="entry name" value="NUCEPIMERASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="7 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5 11" id="KW-0520">NAD</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="12">
        <location>
            <begin position="9"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PCH34309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="377" mass="41258" checksum="CBE9900962311737" modified="2018-01-31" version="1">MSEEPLRRVLVTGGAGYIGSHVIYSLQETRRYKVVSVDNHHNSTPKALVRVAEIARNNLPTDASDKDKDSAEIDAFQADLTKPDEIRKVFATYGKGGIWGVVHIAAYKAVGESTEIPLTYYANNVGATISLLQIMKEFDCTRIVYSSSATVYGTPPVIPIPETTRLQAHSPYGKTKVMCENIIEDICSAEPDTWRALSLRYFNPAGAHPSGLIGEDPRGRPGNLLPLLAQMAIGRVKDPLLKVFGNDYPTPDGTCVRDYLHVLDLAKGHLLALDALAPDSRVFAGIASGQPRFKGYNLGKGKGMSVLQIVEAMRKATGFDYKYEIIGRRKGDVPDLTADPSLAEKELGFTAPQTLETMCRDLWNWQTKNPNGYDGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J724</accession>
    <name>A0A2H3J724_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_107532</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467854">
        <property type="protein sequence ID" value="PCH35573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J724"/>
    <dbReference type="OMA" id="AWCGRPY"/>
    <dbReference type="OrthoDB" id="5386199at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH35573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="167" mass="18472" checksum="788E6C440D0D49FE" modified="2018-01-31" version="1">MTPFIFVLETASNLPLVARFALAGIAMSTSGVSTALVAYCAKPYVNKLRWLEADKQAAGLEMTTLTLGLHERVTRVYDTAFLVPASRFFATWELAEAFQLPKAEAELGKAQGTLPREETVAETLTSKGDVIGRWIVRWDENGAGVCRQQGRVVRYFNVHQELLGRPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J7I1</accession>
    <name>A0A2H3J7I1_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_161375</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH38200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J7I1"/>
    <dbReference type="OrthoDB" id="2816594at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH38200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="163" mass="17377" checksum="F503A540B7EDC00B" modified="2018-01-31" version="1">MPGFCALCSRMSKISDCRGAGKDGRAALRYKAGRAGAWADGQALADSLCRLATTATDSLAVQPRSPSSIPVLLPPPTSRAPSVSFALPADPRADPPQMCHRQLRFYRAAACGHLTFTGDTYIDCKARDCAHSALHPPDCGTPPAVCRCRRYYTCVCPPVRVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J7N7</accession>
    <name>A0A2H3J7N7_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosome biogenesis protein NSA1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WOLCODRAFT_149194</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the biogenesis of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the pre-66S ribosomal particle.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NSA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH38250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J7N7"/>
    <dbReference type="STRING" id="742152.A0A2H3J7N7"/>
    <dbReference type="OMA" id="PRRANIT"/>
    <dbReference type="OrthoDB" id="18388at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22857">
        <property type="entry name" value="WDR74"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037379">
        <property type="entry name" value="WDR74/Nsa1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16038">
        <property type="entry name" value="NOP SEVEN ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16038:SF4">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 74"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="366"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="374"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PCH38250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="409" mass="44752" checksum="8C386A9394099598" modified="2018-01-31" version="1">MPRFFTGDELGSVKSVRYTQGNTPKEWKPDIVTWQEGDGRAKAVQKLAVSNEDSGVQGKLAAARADGSATVFNEGDDSGPSVVHEWQEPRLKSGQRYVGLALSERRVYSCTSNGALRLTQLGNEGTATSTQTSVLPMRICDWRLSQTGDTFAYGGNEVELSVWNTAQAFASREVSTAGDSKKRKRSDQLLPGEIWRAKNLSNDSLSLRQPVHITALTYLQPSSLASHQQLLAGMQEGNVRRYDTRVAKRPVADWKGIGKISGINSIEKGLAEHEVFIADRGCNIFALDLRNGKVAYGYKGLSGAVTSLASSSGLLASVSQDRFFRLHSTFPPPTEVGSQQEQKGEVLDRVFTKTIPSDVIWDGILGDERTDNAAESDGEDAGDDMWEAMEDVDDNDTDARRGKKRRVTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J7T1</accession>
    <name>A0A2H3J7T1_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WOLCODRAFT_130612</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH38001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J7T1"/>
    <dbReference type="STRING" id="742152.A0A2H3J7T1"/>
    <dbReference type="OMA" id="WDRRQPN"/>
    <dbReference type="OrthoDB" id="10260946at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057544">
        <property type="entry name" value="Beta-prop_SPT8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF8">
        <property type="entry name" value="F-BOX AND WD REPEAT DOMAIN CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23798">
        <property type="entry name" value="Beta-prop_SPT8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Transcription factor spt8 beta-propeller" evidence="5">
        <location>
            <begin position="86"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="217"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription factor spt8 beta-propeller" evidence="5">
        <location>
            <begin position="391"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="282"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="15"/>
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</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
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                <person name="Stenlid J."/>
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                <person name="Sun S."/>
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                <person name="Tsang A."/>
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            <dbReference type="DOI" id="10.1126/science.1221748"/>
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</entry>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
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                <person name="Benoit I."/>
                <person name="Boyd A."/>
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                <person name="Copeland A."/>
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                <person name="Ferreira P."/>
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                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
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                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
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                <person name="Lindquist E."/>
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        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
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        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
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        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 3-PHOSPHATE 5-KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 3-PHOSPHATE 5-KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01504">
        <property type="entry name" value="PIP5K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00330">
        <property type="entry name" value="PIPKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51455">
        <property type="entry name" value="PIPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="12">
        <location>
            <begin position="217"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="PIPK" evidence="13">
        <location>
            <begin position="1921"/>
            <end position="2249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="74"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="343"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="884"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1373"/>
            <end position="1422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1587"/>
            <end position="1685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1723"/>
            <end position="1845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="74"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="97"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="134"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="884"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1397"/>
            <end position="1412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1601"/>
            <end position="1615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1623"/>
            <end position="1633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1731"/>
            <end position="1748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1790"/>
            <end position="1817"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PCH34128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="2277" mass="254235" checksum="DF82EB62B608E299" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J986</accession>
    <name>A0A2H3J986_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Phosphotyrosine protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WOLCODRAFT_134215</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB467876">
        <property type="protein sequence ID" value="PCH36363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="742152.A0A2H3J986"/>
    <dbReference type="OMA" id="ERHPIAN"/>
    <dbReference type="OrthoDB" id="2017893at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14498">
        <property type="entry name" value="DSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45948:SF2">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45948">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE DDB_G0269404-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01908">
        <property type="entry name" value="ADSPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="7">
        <location>
            <begin position="32"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="8">
        <location>
            <begin position="95"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="217"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PCH36363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="241" mass="26636" checksum="D2C5175DE4CA53B3" modified="2018-01-31" version="1">MLSFTTPRVESSLVVKSAATIRPRDRLAVGRTASLIVPRLYLANLFTAQDAEQLSKLGITHVVSVLETPPILPSSMPHLKTLHISVTDNINTNILQYLDTTTEFIRDALAESEKNKVLVHCLVGMSRSATVVCAYLIATMSMTPDKAIGLVASQRIVASPNIGFRKQLEQYYARIFPKPPRSPSRMTRVSAGLAGRLRVWKNATVTQSRAVALEVVGARAEPQRDHAEDQRTLDRDENEPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J988</accession>
    <name>A0A2H3J988_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_84641</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
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                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
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                <person name="St John F."/>
                <person name="Stenlid J."/>
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                <person name="Sun S."/>
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                <person name="Martin F."/>
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                <person name="Grigoriev I.V."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF1">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="44"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH38822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="172" mass="19294" checksum="FEC2C7A8C1219E30" modified="2018-01-31" version="1" fragment="single">MTLGVDDVATPLTIRFIDCNAYCAERVLRIWQGADVEKLASLPYATISYVWKGNRKPPVSSSLAVEGAEDGDRLSLEVLHTVCSIALRKGIQYIWLDRLCIMQKLKDDKHWQIRNMAAIYRSCRTCIVLPGGIGGFVGVSERTSWIQRSWTLQETLLPPDVICIVGWELGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
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                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
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                <person name="Martin R."/>
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                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
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                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JAK1"/>
    <dbReference type="STRING" id="742152.A0A2H3JAK1"/>
    <dbReference type="OMA" id="NDENDMP"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH32967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="143" mass="16125" checksum="DCF011EFB7CBB811" modified="2018-01-31" version="1" fragment="single">DRPTNAVTEIHGENDDINEGFGGRHVWLAPKWTDDPKDAAVHFELAIQNVMSTAHYDLAKGARGSYRYLLPMRNPGQKEKITNIHMLKSLEEVSTAPQPFHGMTGDINEGRGSPHLYLVWTVESEKPARPLYISGFNVRFLLQ</sequence>
</entry>
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            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
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        <lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
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                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH39276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="309" mass="34127" checksum="8BB8C7734A1C0A20" modified="2018-01-31" version="1">MGDLLEIGIAVFTDGPYSDCVFSQRLRLDFYQSEDVLRVSRAFKAVQLALMSLHKLYARLQDKPPSKNNIAHIFPSPSPVPSYKGNMPSLSFTDRLSRTGELYLLAKSPDERRSGIYLATMPKSRGTDGPATGSSSGDAPDGQVEVVVKFTTKYNADAHRILADAGLAPALHACIPVCGRLHMVVMERVHGEMAWDVQQRGELLPYTVYKDVKAAINLLHQHNFVFGDLRTPNIMCAPGASSSGSDEGSHAMLIDFDWVGTHGSARYPAILNDTLSVWAFGMQRRAMMYKEHDLAMLEKIRELCQAHTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="1">Uncharacterized protein</fullName>
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        <lineage>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
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                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
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                <person name="Slot J.C."/>
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                <person name="Stenlid J."/>
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                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467942">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JAU7"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH38715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="63" mass="7116" checksum="63DB60577D6C8CDE" modified="2018-01-31" version="1" fragment="single">MTQADASPEKMTLAKRLRLLLPSLLATQRSSWEQGTATHALLDCEYFYSALELSVEAHPYDFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JAV9</accession>
    <name>A0A2H3JAV9_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">L domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WOLCODRAFT_141216</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467987">
        <property type="protein sequence ID" value="PCH39370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JAV9"/>
    <dbReference type="STRING" id="742152.A0A2H3JAV9"/>
    <dbReference type="OMA" id="RRMDRSF"/>
    <dbReference type="OrthoDB" id="1517790at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050328">
        <property type="entry name" value="Dev_Immune_Receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373">
        <property type="entry name" value="SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373:SF275">
        <property type="entry name" value="TIR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="312"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="356"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="325"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="371"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PCH39370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="673" mass="73009" checksum="73210A2E83DB19D4" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JB55</accession>
    <name>A0A2H3JB55_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">26S proteasome non-ATPase regulatory subunit 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WOLCODRAFT_62590</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit p55 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH33904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JB55"/>
    <dbReference type="STRING" id="742152.A0A2H3JB55"/>
    <dbReference type="OMA" id="AENEMFK"/>
    <dbReference type="OrthoDB" id="268763at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000070">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054559">
        <property type="entry name" value="PSMD12-CSN4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040134">
        <property type="entry name" value="PSMD12/CSN4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040896">
        <property type="entry name" value="RPN5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12/COP9 SIGNALOSOME COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22241">
        <property type="entry name" value="PSMD12-CSN4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18098">
        <property type="entry name" value="RPN5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="3">
        <location>
            <begin position="265"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PCH33904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="476" mass="54426" checksum="6D1D2F4F9F43A50E" modified="2018-01-31" version="1">MAENRKQEKDYTKEVDELIPEAQSLAQAGKLQEALDKLLALEKQSRNASDSASTIRLVKQVGELCYAARNYELLNVTINNLSKKHGQFKVAIQAIVEQAMGWLEEIRQREGEGKWLELVDTLRTVTEGKIFLETPRARVTLQLTLYHEALANSPKPGSPSQKESLQTASDLLSDLQVETYSSMERREKTEFILEQMRLLIALARLKDAEVGQEGKKDSIGGGEAEWIKVRVGGRKVNESFLKEKENEDLKFKYYDLMIQHALKHKAYLDAAKYYHTVWETPSVKEDVNGRGREALEHIVYYVVLAPHNNEQSDMLHRVFREPDLERLELHYALIKCFTTPELMRWPGIEGVYGPHLRKTAVFSNDTLWEDLHTRVIEHNIRIIAQYYTRITLSRLTSLLDLTQQQAEETLCRLVVSGTVWARIDRPTGIVNFRSSKSAEDVMNDWSSDMQRLLGLVEKTWMGVNAAQAAQARAAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JBA6</accession>
    <name>A0A2H3JBA6_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_158730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">MD-104</strain>
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        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="160"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH39191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="293" mass="33509" checksum="9AF489B415735011" modified="2018-01-31" version="1">MGVTEDSIMRGSSGNPEPVVSLVSQHTENEHAREARSPNEHDMCGPSWEEELLSEIEALKAQLAKRQQKAASQAPIMTMATHLESPAHEMVRETLGEHSERPGRIHTFPDRGTMFEQNRMGRAKNGRQSELLRPVNQIEPGSYLGDAFHYVGYRAMGDQEGSSEASDISSSTEDSSDDEEAERQTENRHQSHKVPVLKPQEPTSYDGSVDVQAFHKFMREMSEYIRGYKLKVSRHASTISHFLTGTAYEFFVNTVSKNARRWDMKAVFIELFNYCFPVDFRMRMREKLRKSYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JBQ6</accession>
    <name>A0A2H3JBQ6_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Cytochrome P450</fullName>
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        <name evidence="15" type="ORF">WOLCODRAFT_86069</name>
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        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="15 16">MD-104</strain>
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            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis.</text>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
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    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OMA" id="ISATQMF"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cytochrome P450"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="399"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
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        </source>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="473" mass="53983" checksum="372BC00F58AB4762" modified="2018-01-31" version="1" fragment="single">HQFSPTYLQQQFAQWGLKYGDIIYATIFQKPVIILNSAQSAQDLLDQKSSIYSDRPYTILYDQILGWVADIVFMEYGERWKKHRKWAQSAYNDKATLKTYRPIRTREVYALLSNLLDTPDDFGIHIKRYVAALILDTTYGHSISTADDEYVRMADEALAVSTEAGTPGATIIDIFPILRYIQPWVPGASFMRHVHKARPLVEAAADIPYLNVKKSLADGTAKPPLVLSLLKDAIMTGRMTKEHEDDIKGLAAVLYGGGTDTTSSILLTFIMAMTLFPYALQKAQEELDLVVGRHRLPDLEDRDSLPYLDSLIKEVYRWNCSILLAIPHRVMEDDEYRGYHIPKGSMVIPKIWYLFMMRDPSVFADPERFWPERFLEMSPNEAQQKNPINFIFGFGRRICPGRHFADENIWLAIACTASLFNMKKPRDIHGREIAPDAAFSSGFVSHPKQFECEIKPRSEDAVKLLLGYINSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JCH8</accession>
    <name>A0A2H3JCH8_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
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            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
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            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JCH8"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH39591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="145" mass="15499" checksum="16663EF3FF17A7E8" modified="2018-01-31" version="1">MSDMPYADADEEIDANWNWFIIRVENHRALTKQVVSDGCVNYASASWAGSARAGSEAGAADKVCERKEGTSGVDVVQASGVCICRGAYWDKPALGSSRVPPGGYLPYFARVQLDCLLEIAHSGLVSLLVDVTKCMPHSPQPAQAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JCP7</accession>
    <name>A0A2H3JCP7_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_141350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468031">
        <property type="protein sequence ID" value="PCH39661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JCP7"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH39661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="135" mass="15476" checksum="45690B2F8E502FEE" modified="2018-01-31" version="1">MDDFIQKIQKFYAQYLPPQWSAVYSDQRTPGETVELNDDTYNKFRELLKAKGIYNIIIKTVQEEDHMLNATLSGVQDSKLGREDEWLDILVHRLEEPLKRKVANVIQPKESTAAFDEAIQESTAAFGKAIQGSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JE43</accession>
    <name>A0A2H3JE43_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WOLCODRAFT_150541</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468053">
        <property type="protein sequence ID" value="PCH40500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="742152.A0A2H3JE43"/>
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    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19071">
        <property type="entry name" value="AKR_AKR1-5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="4">
        <location>
            <begin position="18"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="4">
        <location>
            <begin position="152"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="2">
        <location>
            <position position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PCH40500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="289" mass="32202" checksum="5197856C3534F2D9" modified="2018-01-31" version="1">MTPPLRAPESRDGEHELSNEAEVGQALKESGFPREELWFTSKLWNTFHALEDIEPALDETLSSLQTDYLDLYLIHWPIAFKKGTSALDEAFTANPYPTWQKLEEPVEKGKIRNIGISNGERAVPPPHTPAHAPLPPPFPSLFCRIENLTANPLKVQPAVNQVELNFWNPQLELLAWSAAHGLRLEAHSPLGSSRQVKDTLAVPAVQAIAKQLGITPAQAIISWHVQRGTIVLPKSVTPSRVVENFQVHALPDDLFEQLEKAAAAHPPQRVVNPSKNWGLDFNVFDDYPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JF66</accession>
    <name>A0A2H3JF66_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">NADH-ubiquinone oxidoreductase 23 kDa subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WOLCODRAFT_137041</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD-104</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I 23 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH40856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="742152.A0A2H3JF66"/>
    <dbReference type="OMA" id="QFFRAPY"/>
    <dbReference type="OrthoDB" id="204405at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="NADH-quinone oxidoreductase subunit I 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01351">
        <property type="entry name" value="NDH1_NuoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010226">
        <property type="entry name" value="NADH_quinone_OxRdtase_chainI"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01971">
        <property type="entry name" value="NuoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004538">
        <property type="entry name" value="PRK05888.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004539">
        <property type="entry name" value="PRK05888.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10849:SF20">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 8, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10849">
        <property type="entry name" value="NADH DEHYDROGENASE UBIQUINONE IRON-SULFUR PROTEIN 8, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <keyword evidence="9" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="8">
        <location>
            <begin position="137"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="8">
        <location>
            <begin position="176"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PCH40856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="245" mass="27292" checksum="36D4D0A0BF1B9A6A" modified="2018-01-31" version="1">MSFLCALVSAGSSARVATRIAAPRASAMLTYRLLSTTPRLSAQEAPKDYLGDSSSSPRSLGTRAATFTAADEPGKNYDPYKDGPSAIDKAVHLFFLTEILRGMWLVLEQVFRPPYTIMYPFEKGPLSPRFRGEHALRRYPSGEERCIACKLCEAICPAQAITIESEARLDGSRRTTRYDIDMTKCIYCGFCQEACPVDAIVETQNQEFSTETREELLYNKEKLLANGDRAEAEIAANLHADHVYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JFC6</accession>
    <name>A0A2H3JFC6_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7918 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_166263</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467843">
        <property type="protein sequence ID" value="PCH35414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JFC6"/>
    <dbReference type="STRING" id="742152.A0A2H3JFC6"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="DUF7918"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36223">
        <property type="entry name" value="BETA-LACTAMASE-TYPE TRANSPEPTIDASE FOLD DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36223:SF1">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR EAF N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DUF7918"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="6"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH35414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="299" mass="33566" checksum="05A7B5C72BF63CB6" modified="2018-01-31" version="1">MHLNNLDISIWCGGRALPEYAVKYEEERTIACYIPSEVGQNFEIRFRDTRQWTSRADGHTLRCAIDGRVMGGSLCGAGQHGSRWGVRVSETSRQMFTFSPLILTDDDDAPHAGGNENLGTIEIKALRVVQQNVREFRRNDVPRVGPIHEKSKKAGSHCVELGQTRTCSPARRIECQYLDPKGVYAARFVFRYRSRELLLAQGIIVKSEADDAASAPRNNKRRADSSPQRNEGEPSRKRQRNSVVQAKRSSSLIEDARPKGGVTGWARARRTPSQTVKKEPQPSQLSVTYSEIIDLTQDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JFH5</accession>
    <name>A0A2H3JFH5_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_143319</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
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            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH40960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JFH5"/>
    <dbReference type="STRING" id="742152.A0A2H3JFH5"/>
    <dbReference type="OrthoDB" id="37297at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33875:SF2">
        <property type="entry name" value="ACR183CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33875">
        <property type="entry name" value="OS09G0542200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH40960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="136" mass="14480" checksum="498772248348EF5E" modified="2018-01-31" version="1">MALQPPLRPLIIAGSPHAPHNPDIFSSPPHSTASLLPMLALAGGPYDGKVEVIFRPQVQPWHASSTLVHEAEFAVARVAPKSFWEFSLAFSKRQGEYFDISTSTQTPLQIRANLAALAAKTIGAGPAGAFAELLTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JG75</accession>
    <name>A0A2H3JG75_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNI-like protein</fullName>
        </submittedName>
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    <gene>
        <name evidence="5" type="ORF">WOLCODRAFT_145604</name>
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    <organism evidence="5 6">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
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            <taxon>Agaricomycetes</taxon>
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            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
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    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD-104</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="742152.A0A2H3JG75"/>
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    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027038">
        <property type="entry name" value="RanGap"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113:SF12">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
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        <property type="entry name" value="RNI-like"/>
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    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="411"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="417"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PCH35007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="468" mass="51828" checksum="05E0BF6FE953D043" modified="2018-01-31" version="1">MMYTLHRRQNSASRSALVSTSQVEQLYGPSSVDGALKVISMMQSRRHVTKLVLGHTDLGDDGCEVLFRFLSSEQGQRYHIINISLNSNGIGDRGLRAITEYLKDNSTLKELFLQNNAFSGAPEVVADFTEALNSSQLEVLSLTTNPRLSDAFIERFLPALDAPFLRDLQLSVLGMTSRSAAHIIEYISSHRCRLRNLSANGNRLGTRGVRFITRALKRHNFSLTTVEMFSNGLFEADASEETSGSEDADTRAGAQIWQESVNELRRILVRNAQLKHATEREALGLLRYARALLFRPRGSSAESFTPTVESRALVPRRSENLLAVIGTPVELLATLHPPSFPFTKLPMELQLYILSFLAPTLSSAQRLRIYTFAASPATLPPLLPNLLMGCRFPNHSVMPLGGAGIGLGMMLRRRNGSSPQSGTTDGKGSVSSLRDEEKSRWLTLMRCDAFELEEDGTWISVNNDDVQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JGA3</accession>
    <name>A0A2H3JGA3_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Zn-dependent exopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WOLCODRAFT_24560</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M28 family. M28B subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="PCH41196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="742152.A0A2H3JGA3"/>
    <dbReference type="OMA" id="HMAGTPG"/>
    <dbReference type="OrthoDB" id="5841748at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08022">
        <property type="entry name" value="M28_PSMA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02121">
        <property type="entry name" value="PA_GCPII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000101">
        <property type="entry name" value="N-acetylated alpha-linked acidic dipeptidase like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.40">
        <property type="entry name" value="Transferrin receptor-like, dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039373">
        <property type="entry name" value="Peptidase_M28B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007365">
        <property type="entry name" value="TFR-like_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036757">
        <property type="entry name" value="TFR-like_dimer_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404">
        <property type="entry name" value="N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404:SF46">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04253">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="3">
        <location>
            <begin position="237"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="5">
        <location>
            <begin position="400"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="Transferrin receptor-like dimerisation" evidence="4">
        <location>
            <begin position="810"/>
            <end position="896"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PCH41196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="898" mass="99171" checksum="C2C49E2AE5EBFA72" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JHC8</accession>
    <name>A0A2H3JHC8_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">WOLCODRAFT_29440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467976">
        <property type="protein sequence ID" value="PCH39243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JHC8"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH39243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="62" mass="6402" checksum="108CBADE4B7F0261" modified="2018-01-31" version="1">MRIAPASITASASIGRRSCNPPGLASGRSAAPEARSQKPHPSLARASQDPSPEALTRIAFPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JHI4</accession>
    <name>A0A2H3JHI4_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Man1/Src1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WOLCODRAFT_136117</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus inner membrane</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="PCH38229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JHI4"/>
    <dbReference type="STRING" id="742152.A0A2H3JHI4"/>
    <dbReference type="OMA" id="KWECGEL"/>
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    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005637">
        <property type="term" value="C:nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071763">
        <property type="term" value="P:nuclear membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12935">
        <property type="entry name" value="LEM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MAN1, winged-helix domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HeH/LEM_domain"/>
    </dbReference>
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        <property type="entry name" value="Heh2/Src1"/>
    </dbReference>
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        <property type="entry name" value="Man1/Src1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041885">
        <property type="entry name" value="MAN1_winged_helix_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47808">
        <property type="entry name" value="INNER NUCLEAR MEMBRANE PROTEIN HEH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47808:SF2">
        <property type="entry name" value="LEM DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HeH"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="22"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="Man1/Src1-like C-terminal" evidence="8">
        <location>
            <begin position="483"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="65"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="110"/>
            <end position="119"/>
        </location>
    </feature>
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        <location>
            <begin position="148"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="273"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="348"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="406"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004540"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF09402"/>
        </source>
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            <dbReference type="Pfam" id="PF12949"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH38229.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="936" mass="101291" checksum="90089A4406CA95C0" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JHM4</accession>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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        <name evidence="1" type="ORF">WOLCODRAFT_28985</name>
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        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
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            <taxon>Phaeolaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
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                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
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                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="PCH37228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JHM4"/>
    <dbReference type="OrthoDB" id="65716at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH37228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="137" mass="15217" checksum="0A185AA4B1F7042D" modified="2018-01-31" version="1">METVAGRYSGISLRSVIATKAYLRGQETISASDALAVNTFEAITDILWVEKDCPVEVLFTALEAILHASLDRNSISIETFSRWLRTICTMLLASLLDEAKRWFEASTTICRFVPDGDSRAAKISETYSQLLERCSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JHP1</accession>
    <name>A0A2H3JHP1_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Pre-mRNA-splicing factor SYF1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Pre-mRNA-splicing factor syf1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">WOLCODRAFT_136145</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in pre-mRNA splicing and cell cycle progression.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the crooked-neck family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH38279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JHP1"/>
    <dbReference type="STRING" id="742152.A0A2H3JHP1"/>
    <dbReference type="OMA" id="IWYNYLR"/>
    <dbReference type="OrthoDB" id="10067343at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000349">
        <property type="term" value="P:generation of catalytic spliceosome for first transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000023">
        <property type="entry name" value="Pre-mRNA-splicing factor SYF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000137">
        <property type="entry name" value="Pre-mRNA-splicing factor syf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000038">
        <property type="entry name" value="Putative pre-mRNA-splicing factor SYF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055433">
        <property type="entry name" value="HAT_Syf1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056350">
        <property type="entry name" value="HAT_Syf1_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055430">
        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045075">
        <property type="entry name" value="Syf1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246:SF5">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR SYF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23231">
        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23233">
        <property type="entry name" value="HAT_Syf1_CNRKL1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23220">
        <property type="entry name" value="HAT_Syf1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pre-mRNA-splicing factor Syf1-like N-terminal HAT-repeats" evidence="16">
        <location>
            <begin position="174"/>
            <end position="265"/>
        </location>
    </feature>
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                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
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                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
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                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
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                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
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            <dbReference type="Proteomes" id="UP000218811"/>
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    </evidence>
    <sequence length="179" mass="20523" checksum="97E9A5F228862ED7" modified="2018-01-31" version="1">MGRWTQYDEDEYRLPEGMQRVGYDADSGKYYFRDRECALWEGTEGVKYGKMRMVSHAPIATGGQDELGDVEAVAKRRPNSGQPRQLLTTTRDLGTNEQRRRISLNRAPPTIPPAEAAPSRVDDYQPLATDLVRPQRCLLLKLVMCKARLKALSRRLRRAGPLVRDFVKFHPKRSQQPLQ</sequence>
</entry>
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    <accession>A0A2H3JIT2</accession>
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        <recommendedName>
            <fullName evidence="4">PH domain-containing protein</fullName>
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        <name evidence="2" type="ORF">WOLCODRAFT_142774</name>
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        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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    </feature>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="PCH39783.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1262" mass="131412" checksum="7299A689DD4498FE" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JJ37</accession>
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        <recommendedName>
            <fullName evidence="4">Guanine nucleotide-binding protein subunit gamma</fullName>
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    </protein>
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        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
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                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
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                <person name="Larrondo L.F."/>
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                <person name="Lundell T."/>
                <person name="Martin R."/>
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                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
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                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
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            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD-104</strain>
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    </reference>
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        <text evidence="3">G proteins are composed of 3 units, alpha, beta and gamma.</text>
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            <topology evidence="1">Peripheral membrane protein</topology>
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    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G protein gamma family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0031681">
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        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0000750">
        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="G-protein complex gamma subunit Ste18/GpgA"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Transducin (heterotrimeric G protein), gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015898">
        <property type="entry name" value="G-protein_gamma-like_dom"/>
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        <property type="entry name" value="GGL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041848">
        <property type="entry name" value="Ste18_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28189">
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    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
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        </location>
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        <source>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PCH37758.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JJH1</accession>
    <name>A0A2H3JJH1_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_158455</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467943">
        <property type="protein sequence ID" value="PCH38919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JJH1"/>
    <dbReference type="OrthoDB" id="5303367at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH38919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="89" mass="10042" checksum="FE4C78710B83DDC5" modified="2018-01-31" version="1">MTFELPLPQLRGFLLDCEKFSQGSMWTRKLCIDEFSEFPPTARIQHGYLSCIWVGGRIVRDSAATWGAFDVKGASQDSVYIGISIFAYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JJQ2</accession>
    <name>A0A2H3JJQ2_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_141050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467954">
        <property type="protein sequence ID" value="PCH39019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JJQ2"/>
    <dbReference type="OMA" id="FEDCTGV"/>
    <dbReference type="OrthoDB" id="3258324at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH39019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="509" mass="58525" checksum="5875C0ECEFD575BF" modified="2018-01-31" version="1">MVCHPPRIRSPGTSRLSRTHMLTSLASRQPRLRRSEPAAAHIPYIPPEIWEIVIKHACLHDHDPIHTSSELSFLESPDTQLASYRSAMRAKLSLAMVSQQWNALSRPYLYEFIWIRRAAQARLLAHTLSYPSFDQDSNGKFLRRLHIETPAFERCSPVDLRSILDHAPNLFIFSDHHSVQRNLLVDDTTDPRCSPEEILKLVVHPKIRRLSWTNYGDAPFQLRMHPLETNLTTRLEFLELSVCSPNFSTLFHGSSPHGGRINMNVCLPALRALKVSLDNDTFAALASWNMPRLTNLSVLSSDFSYTDAGFAQFFQSHGAKLRQLELGHSSSLIEEHYLTTPRSVLQMQQSHGTAQALPLADWCPALRQFICSADAAWRWQSPDWIAPHILLPRHPTVEFIGIRDIDARLLHDPDLPTDPDFYTPYFPLYEQFCSLLDSDAFPKLKFVRDLSPLSHEMRMVRPHPRVLEFWTRVVKRCRQCEIWLEDYTGMNVGLRNLKQATLSDTDSDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JK51</accession>
    <name>A0A2H3JK51_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Elongin-C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WOLCODRAFT_119705</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SKP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468124">
        <property type="protein sequence ID" value="PCH41925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JK51"/>
    <dbReference type="STRING" id="742152.A0A2H3JK51"/>
    <dbReference type="OMA" id="AMVSPII"/>
    <dbReference type="OrthoDB" id="249087at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18321">
        <property type="entry name" value="BTB_POZ_EloC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000035">
        <property type="entry name" value="Elongin C transcription elongation factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039948">
        <property type="entry name" value="ELC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001232">
        <property type="entry name" value="SKP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20648">
        <property type="entry name" value="ELONGIN-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00512">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PCH41925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="103" mass="11666" checksum="276803B5E5674B3C" modified="2018-01-31" version="1">MSDSDWVKLVSRDGHSYLIPRKVAIGSGTLRNMLSAESNFAEAASNTCFIDERAIVVEKLCEYLFYKALYESVPQKEPIPDFQERIPPEVALELLMAADYYEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JKQ5</accession>
    <name>A0A2H3JKQ5_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_158951</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467987">
        <property type="protein sequence ID" value="PCH39379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JKQ5"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH39379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="146" mass="15675" checksum="71E4380BDE837AC2" modified="2018-01-31" version="1">MRDEAESRTPSGLDRPHVGVASQRGGPDAQTLACDGRALRCSPQAPPRREPPVRTADLIVASACMYPVCMRNGHLVAVGENQPELWRLAARSPATIQGIRAQSEQAALASEQSYSDAPSLHSQIAVAATIPWFTTLGVRVCARRHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JL26</accession>
    <name>A0A2H3JL26_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WOLCODRAFT_92104</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD-104</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467887">
        <property type="protein sequence ID" value="PCH36707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JL26"/>
    <dbReference type="STRING" id="742152.A0A2H3JL26"/>
    <dbReference type="OMA" id="SLYWRNK"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PCH36707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="492" mass="55688" checksum="8C0ABE106A6AD7FA" modified="2018-01-31" version="1">MIRAGNYSRIFQDGWDYNLDIVKRYGGAVKITALLGEQQLYISDPRALYNILVKEQDIYEETEMFIMGNQMVFGEGLISTLDLREIDIVPWTSRSALECVSQEGLGHTFNALDMHNTNEYVDAILRLALTALRIIMLRPFVPFVVQNLSLYWRQKLVDWLPIRPLKDLRKIVEIMDKTARRILAEKKARQRELNQSNDGLSDDPPRNGQDIISVLLKANSTSLEDESLTDSEILGQINTLMFAGLETTAIAIARILYILASNSAVQSRLRDEIHKAMRANTLDNDSAQQDVKLPYDILMAPPYMDAVIRETLRVYRPTSLLSRTTKKATTLPLQCPVRLASGETAYSIPVPENTMVIISILAANHNKDVWGLDASEWRPEHWLTPSGERIHFNGDTDNPVTDGKSKSSTFYSTGMYGNQAAIKYPGVSFKFAELEIKQTLAMLLSALHFELPNDKEIHWKMNGLQVPVVCPPTEDDVRAQVPLMIRHLRQGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JLT0</accession>
    <name>A0A2H3JLT0_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WOLCODRAFT_167627</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467931">
        <property type="protein sequence ID" value="PCH37604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JLT0"/>
    <dbReference type="STRING" id="742152.A0A2H3JLT0"/>
    <dbReference type="OMA" id="THAWENT"/>
    <dbReference type="OrthoDB" id="445556at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43096">
        <property type="entry name" value="DNAJ HOMOLOG 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43096:SF52">
        <property type="entry name" value="DNAJ HOMOLOG 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="26"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="127"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="137"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="164"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PCH37604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="233" mass="25976" checksum="874A44726B55DFF3" modified="2018-01-31" version="1">MHIRFAASSAVKHSPRSFHTSASSRGHYHVLNVPQNATKSQIKAFELLQDVANDPKAREKFHAVSEAYAVLGDDRRRRAYDRSLTEGSGSHRTHAAYTAPNASHTHWAYETRRRQGATHAWEYARRPHPAHHRAHQGPTSTASGQTAGSTPPPNDPFSSPHVRRATDQTRAKEHFDPWASPYVRRATGRRDARSLDAGMDKVARISWFWRTTQVVAMVMIISTVTNGLSASAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JMF9</accession>
    <name>A0A2H3JMF9_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Serine/threonine-protein phosphatase 2A activator</fullName>
            <ecNumber evidence="7">5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Phosphotyrosyl phosphatase activator</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WOLCODRAFT_72623</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the PTPA-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="7"/>
    <dbReference type="EMBL" id="KB468124">
        <property type="protein sequence ID" value="PCH42685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JMF9"/>
    <dbReference type="STRING" id="742152.A0A2H3JMF9"/>
    <dbReference type="OMA" id="IHESQDV"/>
    <dbReference type="OrthoDB" id="16120at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008160">
        <property type="term" value="F:protein tyrosine phosphatase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04087">
        <property type="entry name" value="PTPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004327">
        <property type="entry name" value="Phstyr_phstse_ac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043170">
        <property type="entry name" value="PTPA_C_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037218">
        <property type="entry name" value="PTPA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10012">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10012:SF0">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 2A ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03095">
        <property type="entry name" value="PTPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140984">
        <property type="entry name" value="PTPA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0697">Rotamase</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="373"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="421"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PCH42685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="444" mass="49179" checksum="22D17BA5A1D2B1FE" modified="2018-01-31" version="1">MSTGRRDAISAPAVELPPLRQVFIQDLPADNTPATRIRTDEDLEAWKDTRGYQDYGLFIRRLTESVVGYFLPWTNPICQVGTFTQSMIALLDTLDGWIDEIPPLPTPQRFGNLAFRSWGKRLENEADAILSAMLPDSLRAAVPFLAPYLLTSFGSFTRMDYGTGHEASFALLLLCLTLIRFFTPEAPRERELVLCVFVRYMRLCWRLQDVYKLEPAGSHGVWGLDDYSFLGYIFGSGQLRDQSDIPVAAVLHPPLPETNLYFMLIMRIHEVKHGPFHEHSSQLYSIAAGVVTWAKVNSGLIKMYEAEVLGKRVVVQHLPLGGLIEWDARPDAYRVENTEKPTVPQASSHDPLGGVMRAPWSSAAVGAGAQIGRTQAPVPLPTVATQSRRSGPPGPQYDQSSRGRQTLGPPIIPARAPLGPTASTSLQPTRSPKPPSHNLPPRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JMT0</accession>
    <name>A0A2H3JMT0_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_122004</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TCP11 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468146">
        <property type="protein sequence ID" value="PCH43476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JMT0"/>
    <dbReference type="STRING" id="742152.A0A2H3JMT0"/>
    <dbReference type="OMA" id="MNTHEAD"/>
    <dbReference type="OrthoDB" id="276323at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008862">
        <property type="entry name" value="Tcp11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05794">
        <property type="entry name" value="Tcp11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="393"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH43476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="490" mass="54574" checksum="D8AA8E3A6B85B866" modified="2018-01-31" version="1">MSQPHAQREHPPGEPPSLRDRVEDLVHKAFWDEAFESLSNPSPAVQLPRLKKLYEDMHIALKPLLPPDHPVLITLSSPLPPTPAPLRSAILHLREVLVCLRQRSAPARDTQIDSLIAKIDDLSSVASLEQQARLAVGTIQSILELSEAMKDDLSLFVLGTMGERQLREVLRTRAIDQEREIVSELWKSEAIQDSWTKWLSEAPTHATLDQQVSHRMWVYRLVHALGQTVPVSLPFPAPPLPSSSPSAQTEEQPLPSNIIPPPLFFVCSTLLYIQNYLQALVIAASLRSLVRLPPMRSSSPTSQPDPLGNFMTRIWTLLKAEIDVPDASETKLVNLADEVIRVRRLFGSGEAPSADEETRLRAAVDRTLQPRDPVFLLLQRRLLQAVAARLARSQERDAETAGTRLPESLQSGRERPGKRPRLMLQSDARDDHGGSMESSEPSLVIKGFEDEVLIEAVRECVGKLRSCVDWVEEGWSDVIIASVHTHPASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JMX2</accession>
    <name>A0A2H3JMX2_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_90336</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468146">
        <property type="protein sequence ID" value="PCH43526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JMX2"/>
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            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
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                <person name="Benoit I."/>
                <person name="Boyd A."/>
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                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
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                <person name="Ferreira P."/>
                <person name="Findley K."/>
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                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
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                <person name="Lundell T."/>
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                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
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                <person name="Ohm R.A."/>
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            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
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                <person name="Benoit I."/>
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                <person name="Ferreira P."/>
                <person name="Findley K."/>
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                <person name="Gaskell J."/>
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                <person name="Heitman J."/>
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                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
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                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
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                <person name="Ohm R.A."/>
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                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
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                <person name="Boyd A."/>
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                <person name="Hesse C."/>
                <person name="Hori C."/>
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                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
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                <person name="Sabat G."/>
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                <person name="Eastwood D.C."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
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        </location>
    </feature>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <sequence length="84" mass="9441" checksum="4131D0C2F894741F" modified="2018-01-31" version="1" fragment="single">MTILPCASTVGAISHTTSMVAITANVRSRTRDRRACQTRRQFRRLSASRHPRHCIRQVGLVGLTEPCSMCIIGCCHQPMYRTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
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            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Barry K."/>
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                <person name="Igarashi K."/>
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                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
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                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
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                <person name="Wiebenga A."/>
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                <person name="Eastwood D.C."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="OrthoDB" id="2845803at2759"/>
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    </dbReference>
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            <dbReference type="EMBL" id="PCH42043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="153" mass="17310" checksum="77A1175355271219" modified="2018-01-31" version="1">MHSTFYTWSREHIQRVFEAKNEADCLRALNDTFSQKIELSLNGTSLPRTHLQTAIMAMVAGSGFRLSVEWQHANEVPRDPSNSPASQNGTLEGHYVIRGIRKQLPGRSTTALYERHKSVKVVIESESSDRSVDTRRIVKLTIVAKDVPMQSHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Blanchette R.A."/>
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                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
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                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
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                <person name="Martin R."/>
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                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
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                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468157">
        <property type="protein sequence ID" value="PCH44306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="entry name" value="Emp24-like"/>
    </dbReference>
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        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
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    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
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        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
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        </location>
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    </feature>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PCH44306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="221" mass="25433" checksum="B5234518F29F5922" modified="2018-01-31" version="1">MALANRSRLLPLCLLLCLITCTNALHFYLDTNEKRCFVEELPTDTVVEGHYRALEWSEKAQAYVENPDLGVLVEVDELETGHNVVRTRGPNDGRFTFTSHEAGDHAICLSASYPSAGSWFGSTHVRLYLDIVVGATKADQDHDRTHVSELSAKLRDLNQKLEDVRREQQYQREREANYRDLSEATNSRAVWYSIVQIVVLVLTCAWQLRHLKRFFEDRKTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JQA4</accession>
    <name>A0A2H3JQA4_WOLCO</name>
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            <fullName evidence="4">SnoaL-like domain-containing protein</fullName>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
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                <person name="Binder M."/>
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                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
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                <person name="Benoit I."/>
                <person name="Boyd A."/>
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                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
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                <person name="Ferreira P."/>
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                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468157">
        <property type="protein sequence ID" value="PCH44342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JQA4"/>
    <dbReference type="STRING" id="742152.A0A2H3JQA4"/>
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    <dbReference type="OrthoDB" id="3352776at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH44342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="176" mass="19508" checksum="101F86F144816C56" modified="2018-01-31" version="1">MAPTRDQLLTTARALCAAFASAAPVPTLLSHFSATYQISAREHGLPLLAPFLGRTFAGRSGPNSVQAYFELLRQHLTFRNMEFVGWTVDAEASRVCVRGHATFEWTEGEGKGQVWNEVFVYMLDFDEGARVTDYQVWADSGAAYLARRGTLLQQRKEFEASENGAKADDPAPPYVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JQL4</accession>
    <name>A0A2H3JQL4_WOLCO</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_23802</name>
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    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468053">
        <property type="protein sequence ID" value="PCH40048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JQL4"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH40048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="68" mass="7810" checksum="78E2EAF15CA8386E" modified="2018-01-31" version="1">MSPCEVVEKNGWGPCHRHRHVRHTVRIGTAPYLRAHLAALERGNVGLERRGSYFAFAYRSFGTCLARW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JR54</accession>
    <name>A0A2H3JR54_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WOLCODRAFT_154664</name>
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    <organism evidence="5 6">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="PCH44632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="742152.A0A2H3JR54"/>
    <dbReference type="OMA" id="GMEENSW"/>
    <dbReference type="OrthoDB" id="433924at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
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        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
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        <property type="entry name" value="Chromo_shadow_dom"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01393">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ChSh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="8"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="69"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="71"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="126"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PCH44632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="229" mass="26172" checksum="3779E4907F3AC13C" modified="2018-01-31" version="1">MLAGGWGGGIEHILDVQRGAFPNWRTSYLVKWRGCGEEHNIWVDEGDAGNAQGLIDEYWDAKKKRIRGHKSVSSASKLAAAKGRKPVPSKESPELDDTHPKKRGRSSKSTKDEEEEQDEQKQSTHQAKKIKITKSKLSKSNNMSNSDIELIDMRAKFGSATTWEHLVDHIDTVMHDDDDQLYVYFTLKNKARANETARVCKDKMPQKLLDFYEKNLQWRTIEEDDINQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JS17</accession>
    <name>A0A2H3JS17_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein bL21m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WOLCODRAFT_165030</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
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                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL21 family.</text>
    </comment>
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        <property type="protein sequence ID" value="PCH44275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="742152.A0A2H3JS17"/>
    <dbReference type="OMA" id="ITKEPRY"/>
    <dbReference type="OrthoDB" id="5994at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01363">
        <property type="entry name" value="Ribosomal_bL21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028909">
        <property type="entry name" value="bL21-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036164">
        <property type="entry name" value="bL21-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001787">
        <property type="entry name" value="Ribosomal_bL21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21349">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21349:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL21M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00829">
        <property type="entry name" value="Ribosomal_L21p"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PCH44275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="151" mass="16838" checksum="127045B121C94997" modified="2018-01-31" version="1">MASLFRPAASLCATARRAMHTEVMQAPTTTPSALSLIRSQPSQYVVASVAGRKYLLAPRDLLTVPRLKDVRIGDVLQLSEIHEVGSREYTMRGNPTIPAGKVNVQATVVEHTKGKMEVILKKKRRKGYQRTITHKQTYTRLRIGSIDIVDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JSP4</accession>
    <name>A0A2H3JSP4_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_159341</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="PCH41829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JSP4"/>
    <dbReference type="OrthoDB" id="3255996at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH41829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="70" mass="8113" checksum="F7F345105E5649FB" modified="2018-01-31" version="1">MTRGYLEEMGETGAGITWEDEIDMSLDNSFTNKWAQIKGDFPWLWEMKELIGQRPNKIPMGLESYSLNPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JT92</accession>
    <name>A0A2H3JT92_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="1" type="ORF">WOLCODRAFT_137144</name>
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    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
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            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
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                <person name="Binder M."/>
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                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
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                <person name="Benoit I."/>
                <person name="Boyd A."/>
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                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
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                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
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                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH41038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JT92"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH41038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="234" mass="26205" checksum="0176D46019973102" modified="2018-01-31" version="1">MDSDPWDEEIPSSSPEFDGHNYRRWSRGVRCALMRAGVWKCVVSGGPSGKPPFKATSADLYTPTEEEYEEWLLRDDTALAVIRTSLGRGFQHLAYEESSAAALWQRIKARTASPACLGCGRRSRSAGSARIPTRQWETKLMSCWISVMNSPTPESRCPRYNGSLLYSLPFPTPIIIFSTGSLSLTRTRSRLSRRQTSSRVSRAWRVFSGGDAARNVAKTITPLRITARNRISRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JTM5</accession>
    <name>A0A2H3JTM5_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
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    <gene>
        <name evidence="8" type="ORF">WOLCODRAFT_137237</name>
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    <organism evidence="8 9">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH41178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JTM5"/>
    <dbReference type="STRING" id="742152.A0A2H3JTM5"/>
    <dbReference type="OMA" id="HELQAPM"/>
    <dbReference type="OrthoDB" id="3561359at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000082">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF7">
        <property type="entry name" value="DRUG_PROTON ANTIPORTER YHK8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013581419" evidence="6">
        <location>
            <begin position="20"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="241"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="349"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="410"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="9"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PCH41178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="447" mass="49377" checksum="27C63BF04360D8F5" modified="2018-01-31" version="1">MPAVRKWVIVLVISSAALCATFASSAASFTEEGLAEDLHTVHEVTILSISLFVEGLGLGPLLVGPLSEVYGRNNIYRISYILFWVFTWPVAFPPDIATFLVFRFITGFCSSAFLSVAGGSVSDLFANEKVASPMAVYTMSPFLGPVIGPLVSGFICQHANWRWTYRVLLIWQFVTVVLLVVFVPETYEPVILKRKAARVRKEKGDNNYWAPLDRREGSLTQAILFSCYTPFKLLLFDRMALLLNTWNALLLGILYLAFQAFPIIFEDGHGFNTQDTGMSFLGIGVGMLAALATQPIWNRFNRRQMEKYNGKPPPETRLVMGQVGGILAPIGLFWLAFTTYPAVPWIVPIIASVPFGAGVYFIFTSTFTYLVIAYRPIAASAMASNSALRSTFAAAFPLFAKAMYDRLGTVGATALLAGLMTLMTPLPFIYYKMGARLRATSRFAVKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JV39</accession>
    <name>A0A2H3JV39_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_68720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468053">
        <property type="protein sequence ID" value="PCH40584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JV39"/>
    <dbReference type="OMA" id="HILVIRS"/>
    <dbReference type="OrthoDB" id="9876299at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051468">
        <property type="entry name" value="Fungal_SecMetab_SDRs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544:SF36">
        <property type="entry name" value="CHAIN OXIDOREDUCTASE (CSGA), PUTATIVE (AFU_ORTHOLOGUE AFUA_4G00910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH40584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="237" mass="25699" checksum="C0BF64C3DAAF8718" modified="2018-01-31" version="1" fragment="single">SRGLGLAVVAELMKDPENAVVATARNTKQSSGLQELVAKYSSNRLKVITMDISDSASVEKAVEEVTTVLPSGIDCLIHNGAISLQPTSSFAEIDLTLLEQEFRVNTIGPLRVARAFLPLVRKSTQKKIVYISSTLGSIAASPTWIGLSDAYSLTKAALNMHWGSALNAEGITTILINPGWLDTDMGRTLDDLISQRFSWVPKLSADESAVSCIRIIKQAKLEDTVGFYNYDGTLIPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JVS1</accession>
    <name>A0A2H3JVS1_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Branched-chain-amino-acid aminotransferase</fullName>
            <ecNumber evidence="11">2.6.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WOLCODRAFT_153049</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-isoleucine + 2-oxoglutarate = (S)-3-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:18321"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-valine + 2-oxoglutarate = 3-methyl-2-oxobutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24813"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.42" evidence="11"/>
    <dbReference type="EMBL" id="KB468135">
        <property type="protein sequence ID" value="PCH42999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JVS1"/>
    <dbReference type="STRING" id="742152.A0A2H3JVS1"/>
    <dbReference type="OMA" id="TGPYFRT"/>
    <dbReference type="OrthoDB" id="1732691at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052656">
        <property type="term" value="F:L-isoleucine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052654">
        <property type="term" value="F:L-leucine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052655">
        <property type="term" value="F:L-valine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01557">
        <property type="entry name" value="BCAT_beta_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.10:FF:000002">
        <property type="entry name" value="Branched-chain-amino-acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018300">
        <property type="entry name" value="Aminotrans_IV_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005786">
        <property type="entry name" value="B_amino_transII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033939">
        <property type="entry name" value="BCAT_family"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01123">
        <property type="entry name" value="ilvE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009897">
        <property type="entry name" value="PRK13357.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825:SF44">
        <property type="entry name" value="BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825">
        <property type="entry name" value="SUBGROUP IIII AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006468">
        <property type="entry name" value="BCAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00770">
        <property type="entry name" value="AA_TRANSFER_CLASS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 11 12" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7 11" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 12" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR006468-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PCH42999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="396" mass="43324" checksum="685E27DCE8738E23" modified="2018-01-31" version="1">MAIEAANGSAVANGSASKQGPLNLDASKLKVIRTEAPRAMPSPENLKFGQTMTDHMLVATYDPINGWSAPEIKPYGPFALDPASSCFHYSTNLFEGMKAYIGPDGKPRLFRPELNMARMKKSADRIALPPFDTEELLKLIKRLVAMDAHWIPTLPGHSMYIRPTMIGTRPNLGVAASDHAMIYVICCPTGPYFRTGARQISLLAMGETVRAWPGGTGGYKLALNYAPTLKPQQVAEQQGYNQVLWLLGDRVTEAGAMNFFVVVKRDDDNWDVYTPPLDGTILPGITRDSCLALAGAHPSRTVLPHLPETLRLHPQERPVTMSDLAQWHAEGRLLEAFTVGTAVVVTGVGRIGYQGKNIELPIHEGGRGPLAQALYERIMDIQEGKVEWEGWSVPCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JVU3</accession>
    <name>A0A2H3JVU3_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_136760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468053">
        <property type="protein sequence ID" value="PCH40277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JVU3"/>
    <dbReference type="OMA" id="FRISVME"/>
    <dbReference type="OrthoDB" id="2921803at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH40277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="468" mass="53987" checksum="9557BFA2136278C9" modified="2018-01-31" version="1">MSLESSLSQLNLLLQGQQENDGDSKRKRSWRRSLTSVIRRKRLSRPVIEKVFNDTVISDEAPPNREATPNRRLPAELCDRIVDFLHDDPYTLAACCLTCRSWVPASRHHLFYNIRLTRENVARFNLILDANVSLGLCVKVVTVDYRLQHKDFVKGVSDRFAKDCAHLEEAIKRLHNVTTLRFTEIHLDSRMTKRIALLSQSLETLEFDSLVICDRQQLAEAIYSLPRLKTLVIKGHFCGTSWTTTIPSPLRPDPPTLSHLFITLVPFGDDIQALLAPLTTSKILCMLKELTVIAYEARGLDALFAELGPALETLTIVMHRLVDPRDIRCNLAQCTNLRRIRFMASTPFLLPQRWHFYRRPPPPQPTWVAKFLSQISTDSVRSVAIAFDPNQRTGLPDLSWVEEMALPLSRPEFKELNTVAFQITSIRYERQLRDYIRRELPELCERDIVTIRSLPLRRADRERDLVFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JXJ3</accession>
    <name>A0A2H3JXJ3_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosome biogenesis regulatory protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WOLCODRAFT_150923</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in ribosomal large subunit assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the RRS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH40897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JXJ3"/>
    <dbReference type="STRING" id="742152.A0A2H3JXJ3"/>
    <dbReference type="OMA" id="ACDKNRI"/>
    <dbReference type="OrthoDB" id="28455at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007023">
        <property type="entry name" value="Ribosom_reg"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04939">
        <property type="entry name" value="RRS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="75"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="145"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="286"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="158"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="183"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="210"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="286"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PCH40897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="310" mass="33977" checksum="08F06D982E9158EF" modified="2018-01-31" version="1">MDVSDILAAHAEKQKAVTVEKDIPLVIDAGFLTVTDLNPVDAESYNEDLEGYLMSTARDGIQALVGALFSLPTTSSEEGPIAQLPPPTTQLPRAKPLPKPKPPTKWELFAKAKGIQHRKRDKKVWDEEKQEWVNRWGWKGANKDKETQWLTEVPANADVDHDPRKAARDERKARIAKNERQHQQNLARVQGASAQSGTAPNADRKKQIDRTLATTRTSTASMGKFDRTLEGEKKLKGVKRKAKVSADAEKSRDLAIIQKLEREPSAKKAKSSSGNGVLNVRKAIRAASKGKGSAALARESGGGKGKKGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JXS4</accession>
    <name>A0A2H3JXS4_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS Git1p-like glycerophosphoinositol permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WOLCODRAFT_78218</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB468168">
        <property type="protein sequence ID" value="PCH44783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JXS4"/>
    <dbReference type="STRING" id="742152.A0A2H3JXS4"/>
    <dbReference type="OrthoDB" id="2153661at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046943">
        <property type="term" value="F:carboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
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        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
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        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
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        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="146"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
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            <begin position="301"/>
            <end position="321"/>
        </location>
    </feature>
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            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="366"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="396"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="9"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH44783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="463" mass="49840" checksum="4B6B7E3C43E61130" modified="2018-01-31" version="1">MAATTTYMAIFAAAFGLLSDGYHNNLMTMTNVVFKRLYPSGYTTSVSTRVSNALLVGEIIGQVLLGLICDRIGRKAGLVLTTLLIVVGATLCTAAYGAHEDPYTLFWLMTIGRGITGVGTGGEYPASSVSAIEAIHERSAENRASVYILVTDFPLVIGGPLTASVFLIVLSALGQGRLGAVWSVCFGVGMVFPLAVFAFRMRMLSSKLYSDSAIKRRVPYTLAIRKYWRALLGTCGAWMIFDFIYYPNAIFSATIISSVTANRDLRSVAEWQLLLGIIALPGVFIGILLCNYLGRRNTASFQMILGFSGYVIFGLIIGLAYERLVKIMPLFVIFYGLMASMGNLGPGNMTLVVSAESYPTSIRGTCFGLSAALGKTGAAIGTQVFTPIQDSLGQKWTFIVAAIFGILGMLVTYFFVPDKRGLDLACEDEEFLKYLSENGWDGVVGDRGGEIATSGDPKSSDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JZQ6</accession>
    <name>A0A2H3JZQ6_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein BIG1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WOLCODRAFT_137520</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BIG1 family.</text>
    </comment>
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        <property type="protein sequence ID" value="PCH41647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037654">
        <property type="entry name" value="Big1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28285">
        <property type="entry name" value="PROTEIN BIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28285:SF1">
        <property type="entry name" value="PROTEIN BIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013729495" description="Protein BIG1" evidence="11">
        <location>
            <begin position="20"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="236"/>
            <end position="261"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PCH41647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="281" mass="30214" checksum="A69ED6A0B968B2CC" modified="2018-01-31" version="1">MAGRAAWIIATLLPATCLAFSNTNPIVAWSAHSSNVLDSASSAKSSWNILEDMLLDKQICQHDAIVLVDQKGLHASDLRTLPTSSVLSQSLYFAASALEMPYVTRSISHPYENLVHTVAEHCDARVVHHTPGQMGIPYDAKEKHVVCIEMPALESPYGTTRKSIMAEHESALSSTLSELSDVFPNHIVVYAGWSPSLRARQSSDPFSSTAVVNPSAAFAPPDGGILARYQLLTPGLIISLLVGFFVLLPTVLMGINALAAIKSPLQGEPPKGYIASEKKNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K0R5</accession>
    <name>A0A2H3K0R5_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WOLCODRAFT_73317</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB468124">
        <property type="protein sequence ID" value="PCH42007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K0R5"/>
    <dbReference type="STRING" id="742152.A0A2H3K0R5"/>
    <dbReference type="OMA" id="MEPWERM"/>
    <dbReference type="OrthoDB" id="202672at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024512">
        <property type="entry name" value="Ser_palmitoyltrfase_ssu-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11779">
        <property type="entry name" value="SPT_ssu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PCH42007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="117" mass="13335" checksum="C139B055CE5EFB32" modified="2018-01-31" version="1">MSPETWRRVPTAAAAIFGITIPYRPPTNPIGAFLWRKRILFETTTGLALLERWEKILMLCIVYSILTLVVTGLYKYAPQYAVFVKHRTAYYLFGQEPEESVGRQVAGWVVRNVGGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K147</accession>
    <name>A0A2H3K147_WOLCO</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_26228</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K147"/>
    <dbReference type="OMA" id="FGDIAFW"/>
    <dbReference type="OrthoDB" id="10261040at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH43838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="189" mass="19633" checksum="767E1A0302FD0B0C" modified="2018-01-31" version="1">MSVTASAAQAVSATVAALFPEAGRSSVLLDDELILYPQGRPEDEAIAGYLAGLTAHANVAANSIACGSILAGPSSETDEFGDIAFWLGEGDFGAGHETQVLEALHLAALLTAQTMISPIILSSYLPAAQRLSSPNGETQRLIGELGQLRDAWCFRVERLAGSEGLVMYVLVGFKDGAGWAGLLGLGVWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
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    <name>A0A2H3K272_WOLCO</name>
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        <recommendedName>
            <fullName evidence="4">MATH domain-containing protein</fullName>
        </recommendedName>
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        <name evidence="2" type="ORF">WOLCODRAFT_144397</name>
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        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
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            <taxon>Phaeolaceae</taxon>
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
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                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
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                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
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                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
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                <person name="Kumar T.K.A."/>
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                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
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                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="PCH43144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
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    </feature>
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        </location>
    </feature>
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        <location>
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            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH43144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="490" mass="54752" checksum="09487C6EF2468226" modified="2018-01-31" version="1">MPTSLQRHEYKVSVTASFLLDNLKELFGLESSQGGTSSKKCYTTDSFGPCWNIAYEGFRPREDDDGYVSIWFDAAGTPSAPLYCSITAESRDGTRHFDGSFTWSFPPGQRRYGWKKALLRSRKWDQNDTLQQENALLVTVTVQSSPEGFDTNTKETLSLLHRTITGNDSESRMVFTTFARRSSFCTLSNGCTLFADNDIMEKFCNHWNNPSIVRMVDKGAAEVIAYDTDYAYDDSDFDEDLTEDDIDINSHAPHVDHDMRAKDEECAHSTVSTAEDSSSTTDESEIETLEASSATSQGSEPATENDFNNVSGHPSLTQIEVACQTIPHIHAPRIVVVGAASTTWEALLFYLHSGTITFAPLTSGGASVRRAFINNHKQTRPHLPAPCSCKSIYHLAHELQLERLQKLAMDHLRSQLSRRTILAEIFSQFTSRFDEVKNIELEVLRSHWSEIVGTTELQEMLTKVVCGDYPHANKVMADIMKYLTGNISGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K343</accession>
    <name>A0A2H3K343_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_145044</name>
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    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K343"/>
    <dbReference type="STRING" id="742152.A0A2H3K343"/>
    <dbReference type="OMA" id="DDHVNVH"/>
    <dbReference type="OrthoDB" id="3362371at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12460:SF0">
        <property type="entry name" value="CID DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12460">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE INHIBITOR-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013689043" evidence="2">
        <location>
            <begin position="23"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
    </feature>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH44558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="895" mass="93842" checksum="8C6AA7076CF458A6" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K3B5</accession>
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    <protein>
        <recommendedName>
            <fullName evidence="4">ATPase inhibitor, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WOLCODRAFT_152952</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Inhibits the enzyme activity of ATPase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the ATPase inhibitor family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468135">
        <property type="protein sequence ID" value="PCH42897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K3B5"/>
    <dbReference type="STRING" id="742152.A0A2H3K3B5"/>
    <dbReference type="OMA" id="AHEDLYV"/>
    <dbReference type="OrthoDB" id="5532350at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042030">
        <property type="term" value="F:ATPase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.500">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007648">
        <property type="entry name" value="ATPase_inhibitor_mt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04568">
        <property type="entry name" value="IATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64602">
        <property type="entry name" value="F1 ATPase inhibitor, IF1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="42"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU368087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PCH42897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="78" mass="9073" checksum="3DCD08313F80E23D" modified="2018-01-31" version="1">MLSRIATTSARRIPRVTPAATRLYSEDAFNKKEKAHEDQYARQHEKEQLKKLKAEIERKKAELAQLEKEHAEAVSKQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K4P2</accession>
    <name>A0A2H3K4P2_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_154069</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468157">
        <property type="protein sequence ID" value="PCH44024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K4P2"/>
    <dbReference type="STRING" id="742152.A0A2H3K4P2"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="370"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="307"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH44024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="477" mass="51487" checksum="492EB6163DB34690" modified="2018-01-31" version="1">MPTITSAFNSLDEQSWIATAYLLMSTVFQPFFGHACDFFGCKVQRNGRDRIRNVWENMRDCLGLHSRNSVLGGLNSMQSDGASDHMRPGDMMLAEMARALNIGLGLPNDNSVPTGTSSDRTGPSGEAGSGGNTSSQTVTTDSADRPAPAEDSFEHFLLNLWNDLRIALSEDGAAERPQRDSVHSSHSSSSTTPAQQDLAPVAGPSSMHSGTSVNQSEYPVPESEDPDEDNPPQLEDGSDSEDEYDVDDEEDMDDEHDVHDEHDHGTDTPHSPRSPTPIPGGRRAPGVNLWRLYRFQPIPALQTQGHAATTSVAGSATSDSHPPSSTTTTPLDTPAEGAEPSEPQAPSPAATHPNANVVVPVIVVDHMQPSDDVRSTESSLGSAENWQNQSSTAPMDIPSRGRPWHSRAADALRPLLPGRRSGSHNRQSTDANGARTFLIYVIGGYYPPNHHMVTGSDSLDSYEALWELAELLRCRRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K511</accession>
    <name>A0A2H3K511_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ZIP zinc/iron transport family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WOLCODRAFT_138787</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ZIP transporter (TC 2.A.5) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468157">
        <property type="protein sequence ID" value="PCH44134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K511"/>
    <dbReference type="STRING" id="742152.A0A2H3K511"/>
    <dbReference type="OMA" id="CWVEGII"/>
    <dbReference type="OrthoDB" id="448280at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004698">
        <property type="entry name" value="Zn/Fe_permease_fun/pln"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00820">
        <property type="entry name" value="zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF32">
        <property type="entry name" value="ZINC-REGULATED TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="61"/>
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            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
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                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
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                <person name="Kallen N."/>
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</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
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                <person name="Riley R."/>
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                <person name="Boyd A."/>
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                <person name="Ferreira P."/>
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                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 9">Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH33156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3IT44"/>
    <dbReference type="STRING" id="742152.A0A2H3IT44"/>
    <dbReference type="OMA" id="EMQYHTL"/>
    <dbReference type="OrthoDB" id="10056816at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055029">
        <property type="term" value="C:nuclear DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10507">
        <property type="entry name" value="Zn-ribbon_RPA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012164">
        <property type="entry name" value="Rpa12/Rpb9/Rpc10/TFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006288">
        <property type="entry name" value="TFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034004">
        <property type="entry name" value="Zn_ribbon_RPA12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001529">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01384">
        <property type="entry name" value="TFS_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239:SF12">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02150">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005586">
        <property type="entry name" value="RNApol_RpoM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00661">
        <property type="entry name" value="RPOL9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00466">
        <property type="entry name" value="ZF_TFIIS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9 11" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="1 6 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 7 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS-type" evidence="10">
        <location>
            <begin position="83"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="7">
        <location>
            <begin position="14"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR005586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PCH33156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="126" mass="14054" checksum="0B3090C29F399A91" modified="2018-01-31" version="1">MPSRAHKIGSLLFCPDCGTLLNLPQDGDTKVPCEQCGYEEPASSYENIEIVTRSHPDAFPSPLRQKGKTQTKVHEANEALLKVTEKCPECGHMEAYSQEAQLRSADEGSTIFYTCVKCKYGWRVNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3ITP1</accession>
    <name>A0A2H3ITP1_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">chitin deacetylase</fullName>
            <ecNumber evidence="20">3.5.1.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">WOLCODRAFT_21945</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25 26">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + n H2O = chitosan + n acetate</text>
            <dbReference type="Rhea" id="RHEA:10464"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9597"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57704"/>
            <dbReference type="EC" id="3.5.1.41"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:10465"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the polysaccharide deacetylase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.41" evidence="20"/>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH33356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3ITP1"/>
    <dbReference type="STRING" id="742152.A0A2H3ITP1"/>
    <dbReference type="OMA" id="AWQMGLT"/>
    <dbReference type="OrthoDB" id="407355at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004099">
        <property type="term" value="F:chitin deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.370:FF:000004">
        <property type="entry name" value="Related to Chitin deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050248">
        <property type="entry name" value="Polysacc_deacetylase_ArnD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587:SF133">
        <property type="entry name" value="CHITIN DEACETYLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587">
        <property type="entry name" value="GLYCOSYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0134">Cell wall</keyword>
    <keyword evidence="18" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="12" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="16" id="KW-0170">Cobalt</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="17" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <keyword evidence="10 23" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="23">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013601589" description="chitin deacetylase" evidence="23">
        <location>
            <begin position="20"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="24">
        <location>
            <begin position="187"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="22"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="422"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="22">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00024056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="PCH33356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="486" mass="50932" checksum="6FE2CDD136382910" modified="2018-01-31" version="1">MKYTTLSALALPVLASAHGHGVAHRARQDDGSAELSDANAAGTGTATNSLPTTISFSLITENPTAIPISDIRTGTAQLQSTIAISTTYAAGARPTQISSAAGLPDALALNPKDYPTLDKTPPTDTPEVQEWISQVMNSGVDIPDIPVTNPGGCGNNTAALANAAQNCWWTCGGCVRDTDITTCPTKDSWGVSYDDGPSPYTPNLLQYFDQEDIRATFFVVGSRAISRPAMLQDEYMMGNQIAVHTWSHPYMTTRTTEEVIAELGWTKKIIHDALGVTPLYWRPPYGDIDDRVRAISTAMNLTPIMWTRISADMTFDTTDWSIPGGTSTAASVLDKWNLIMGNSTKIDTGFIVLEHDLFEQTVDIATGYILPQALAHVPKYNMTPIIECLNMPLANSYIETNDNSTNPPPLAAALANRTSTSGSASAGTASSTASSSSSSSSGHSGSGSSSEGSTSSSSGAAAGIAFNSGLISAALGMVAGASALLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3ITW5</accession>
    <name>A0A2H3ITW5_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="15">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">WOLCODRAFT_160059</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA.</text>
    </comment>
    <comment type="function">
        <text evidence="15">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="15">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="15"/>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH33426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3ITW5"/>
    <dbReference type="STRING" id="742152.A0A2H3ITW5"/>
    <dbReference type="OMA" id="LMEFHSQ"/>
    <dbReference type="OrthoDB" id="10259640at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17942">
        <property type="entry name" value="DEADc_DDX18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000379">
        <property type="entry name" value="RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000460">
        <property type="entry name" value="RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044773">
        <property type="entry name" value="DDX18/Has1_DEADc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025313">
        <property type="entry name" value="SPB4-like_CTE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13959">
        <property type="entry name" value="CTE_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01178">
        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8 15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="19">
        <location>
            <begin position="22"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="17">
        <location>
            <begin position="53"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="18">
        <location>
            <begin position="243"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="467"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="13">
        <location>
            <begin position="22"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="16">
        <location>
            <begin position="468"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="487"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="528"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="PCH33426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="562" mass="62904" checksum="6E628BADBA0B197F" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IUL9</accession>
    <name>A0A2H3IUL9_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GST N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WOLCODRAFT_22163</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH33676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3IUL9"/>
    <dbReference type="STRING" id="742152.A0A2H3IUL9"/>
    <dbReference type="OMA" id="AEKFTIY"/>
    <dbReference type="OrthoDB" id="412788at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00299">
        <property type="entry name" value="GST_C_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044617">
        <property type="entry name" value="TCHQD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45374">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE TCHQD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45374:SF1">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE TCHQD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="2">
        <location>
            <begin position="6"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="3">
        <location>
            <begin position="179"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="99"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PCH33676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="355" mass="39122" checksum="6CC27DC4E53BE6F2" modified="2018-01-31" version="1">MTTDVPKAALYYFPKAIWPSAPLLALEEKGYGSDEIDLKLVDLSKGENYAPSYLRLNPNATVPTLVVPLHNTLSPEVESRYKSLQDTKSIVEFLDKSRSTQSRTHTTSSAPSPSLSPATIAFSAISDKIIDLLHSPAADPNALLYLNARNEAALQELSRERLQTLSARRDAVAQLLTDNESAKIRVSEKTRQFWELKRVAIEKFLDVYQAADKPTSALDDAAKTKREAYFSDATTAWAGLQGVLIELNQEIIGPYVLGDQLSIADLHLAPWLARLVKLSGGTIADDGNIAVGKLEEHVSVGFSLPQDVAVTESRRRAGLPIPDPESSERQNRLAAFWDAIKERPSFKKVYADDLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IUX5</accession>
    <name>A0A2H3IUX5_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Acyl carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">WOLCODRAFT_22235</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Carrier of the growing fatty acid chain in fatty acid biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acyl carrier protein (ACP) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH33776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3IUX5"/>
    <dbReference type="STRING" id="742152.A0A2H3IUX5"/>
    <dbReference type="OMA" id="RFKTPRD"/>
    <dbReference type="OrthoDB" id="448946at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099128">
        <property type="term" value="C:mitochondrial [2Fe-2S] assembly complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000035">
        <property type="term" value="F:acyl binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000036">
        <property type="term" value="F:acyl carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.10:FF:000003">
        <property type="entry name" value="Acyl carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01217">
        <property type="entry name" value="Acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003231">
        <property type="entry name" value="ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00517">
        <property type="entry name" value="acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002148">
        <property type="entry name" value="PRK00982.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20863">
        <property type="entry name" value="ACYL CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20863:SF28">
        <property type="entry name" value="ACYL CARRIER PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="13 14" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="6 14" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 14" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Carrier" evidence="15">
        <location>
            <begin position="53"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PCH33776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="131" mass="14171" checksum="B24AB0593FE3DFFD" modified="2018-01-31" version="1">MSFLRLAARSVARPQVASAPRVVLPRAAAALPQSRGRVLQYAAYSAAAGLSKSDITARVLDVLKGFEKVDPSKLTETSRFSEDLGLDSLDAVEVVMAVEEEFAIEIPDEEADEIKTVQQAIEYIAKTPEAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IWB6</accession>
    <name>A0A2H3IWB6_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pre-mRNA polyadenylation factor Fip1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WOLCODRAFT_135605</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
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            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Barry K."/>
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</entry>
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                <person name="Nagy L.G."/>
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                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
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                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD-104</strain>
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    </reference>
    <comment type="function">
        <text evidence="4">Essential for proper morphogenesis of the vacuole. May exist as structural reinforcement on the surface of the vacuolar membrane and be required for maintenance against rupture by osmotic pressure.</text>
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        <subcellularLocation>
            <location evidence="1">Vacuole</location>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SORTING NEXIN-13"/>
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    </dbReference>
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    </dbReference>
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    <feature type="domain" description="PX" evidence="8">
        <location>
            <begin position="2"/>
            <end position="118"/>
        </location>
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        <location>
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            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
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        </location>
    </feature>
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        <location>
            <begin position="327"/>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00054927"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Coils"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH33603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="359" mass="40005" checksum="273661BF16870CF0" modified="2018-01-31" version="1">MAAIQAIHIRGFEERAEPKPHVVYRIEIQASVRSWQMWRRYSEFADLHVELTKSSGAAPPAELPPKKSLAFFKARDAAFLEERRAGLELYLRAILSAKDDRWRESFAFRDFLGVPVGKQPGADGAAPSQFTSSSWLDEHQDLLARVRDVRADINKRDALSDRGDIAGSHQSNVQAKKKLAGILTRVGVLEDGLRALGLGGMSEGELQRRTDMVSRLRDDCEKLAKMVTVARMTSRGLGSAAERNPASPSDRAALLDSPSSSGFSRPVTRVFGAAARPQETEQTRPLDDHGVFQLQQTQMENQDQQLAQLSTILQRQKHLGLAIHSEISEQNEMLDDLTSEVDRVGNKLTRTKRQMNRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J2J5</accession>
    <name>A0A2H3J2J5_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WOLCODRAFT_108360</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Basidiomycota</taxon>
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            <taxon>Agaricomycetes</taxon>
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        </lineage>
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    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    </dbReference>
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        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
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        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF29">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
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    </dbReference>
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        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
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    </dbReference>
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    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
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    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="15"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PCH36201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="568" mass="62766" checksum="7119E2C5CE77FEAD" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J2N8</accession>
    <name>A0A2H3J2N8_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WOLCODRAFT_22417</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
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        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD-104</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="PCH34043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="FAD-bd"/>
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        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051104">
        <property type="entry name" value="FAD_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720:SF3">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01460)-RELATED"/>
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    </dbReference>
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        <location>
            <begin position="10"/>
            <end position="172"/>
        </location>
    </feature>
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        <location>
            <begin position="298"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PCH34043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="423" mass="45561" checksum="CC761A3E3626C53C" modified="2018-01-31" version="1">MTASESKGIKVAIVGGGVCGLTCAVALLRRGIHVEVFEAAAQFGEIGAGVGIGPNATRLLEHLGVLEEVLKETLEPGLTMGPFLFLSGMEGHEMLYEYPERDHGLGAHRPSFLNAMVKFVDPSITHFNKRCTSVAPSASNPGRTMIHFADGTTHEADVVIGADGIKSSVRPYVAGDDASRVIFSNTICYRGLIPMATVRAAGVTLDFSQSRTSILLGVDRHIVVFPVRGGNLVNVVAFHADHNAPLGSPQLPRDEWVKPVSQQELLDVYAGWGPEVTGLLNCIKTPSKWSIHMVYPPLESYVKGNVALIGDAAHGMLPHMGAGAGQGMEDGYILAQLLAHPQTSNTSLESVLRAYDRVRRPRAQMVWNGSYNTGKIYDGKGEHGLNADGVKQDIGTRWDDVWHHEVDDDVTLAVAWLKEISAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J2W3</accession>
    <name>A0A2H3J2W3_WOLCO</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467876">
        <property type="protein sequence ID" value="PCH36506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="742152.A0A2H3J2W3"/>
    <dbReference type="OrthoDB" id="10039566at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH36506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="348" mass="39792" checksum="E0628055F61F2269" modified="2018-01-31" version="1" fragment="single">ELEWEGLPSDHILEFVHPLTVLFHGEAVADAIIKDAFKTSSRHLCFSLVARDSGAFQEYMKTLLREDDVQVVLQINGFKYYPVDQRERPADWDTYVYTEPWKKTLVFKGFQSFRNRIRLQEIKINGSDLDEDGIPYLRAMVAAEVHNDTRMTCTVNFSLEAFYKESRVNRKNIQEVDGCFQPIYPPSEEVKQFISSYLTKGTPLQIQLHVDDISITICHRLYNIPGFAVNTHIHGLNRPIVTHVDAYLSFFPIILRRRVAFRFYLVNPVATPVEFNSFTVHASVKGTPIANVEYSAKKALSVSVCIDGLIKCPKMKKAYLISGLIKTAQLAFDRSATLHLEIKRASIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J355</accession>
    <name>A0A2H3J355_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Actin-like ATPase domain-containing protein</fullName>
        </recommendedName>
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        <name evidence="1" type="ORF">WOLCODRAFT_20683</name>
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        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
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            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467887">
        <property type="protein sequence ID" value="PCH36680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OMA" id="FVITHPN"/>
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    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10170">
        <property type="entry name" value="ASKHA_NBD_HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF5">
        <property type="entry name" value="HEAT SHOCK 70 KDA PROTEIN 12A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH36680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="281" mass="31282" checksum="F6BCEB0A07B486D0" modified="2018-01-31" version="1">MSALHIVESHTRYWTQEKYPQFEESPASGQVYAVGAEAALPHMADEAVARNLIFVEWFKLHLRPTTLRSEQEISARVPPLPSGKTVIDVFADFLRYLYACARRYIVETHANGENLWSSLGSRIEFILSHPNGWEGNQQTKMRRAAVQGGLVPDDSTGHARIHFVTEGEASMNYCLNSGLAANSVKEGSCVMIVDAGGGTVDLSTYKFTKMVPLTIEEVVAPDYKLRNSVYRADIKAMLEYFDKSTKPLFKARNDACYIKFGSLGCSDSTVQIRRGQMLLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J382</accession>
    <name>A0A2H3J382_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_157409</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
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                <person name="St John F."/>
                <person name="Stenlid J."/>
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                <person name="Syed K."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
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    </reference>
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            <end position="24"/>
        </location>
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    <feature type="compositionally biased region" description="Basic residues" evidence="1">
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        </location>
    </feature>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="PCH36710.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
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                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
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                <person name="Sabat G."/>
                <person name="Salamov A."/>
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                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
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                <person name="Eastwood D.C."/>
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                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
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    </dbReference>
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            <begin position="40"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH36732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="328" mass="36622" checksum="9E78F901F2202CD6" modified="2018-01-31" version="1">MVCYTSTTVTFSYGGALHLNLKLVAKHYLPIKPAVQGVTLLFTHGIGAHKEVWEPMLEILLRNANAIGIHDAWSIDWQSHGDAAAVNDLVLREIPDGISTREYAVGLRAFAMSLFMKSCSEIIGIGHCAGSSALLLSTHTTPVPYAAIVLVEPGLYERTVWYKDHEKHMASCKAMYDAISGRRDTWNSREEATAFFKQRDPWKRWDERVLNAHVVYGLKDHAIEEGGRQVMKVTLKCHKFQERMPLKDDIEIFLDAADTLRTLDASFPIHCVLGMRNDVMYSILAMRRMASIQYIPGAGHAVVQENPDDVATCLHNILHGIGSPSVKL</sequence>
</entry>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Barry K."/>
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                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
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                <person name="Benoit I."/>
                <person name="Boyd A."/>
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                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
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                <person name="Hori C."/>
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                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
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                <person name="Lundell T."/>
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                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
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                <person name="Wiebenga A."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="12"/>
            <end position="30"/>
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        </location>
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        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH37132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="244" mass="25881" checksum="F042D419028B9134" modified="2018-01-31" version="1">MPEINCQVGLRVLSALGNVAVVAASTNLLIRTLTLWKQNTQIKALLITMGIAQLFIGLSVGMMNVGQASTDNPALCGNVHTNRHHELIIFFAYTLHYDIAIFVFTLLGLGPRRTGEHAHSRVWESVYRHGLSYALTTTIVNVPVVVLACLNLNSVMNIMLFIPATTVSVIASSAAVISLRSANEPAATGSGMRNLNGAERLSSKETPSDPLSTYIEITPSFGSVEAGMPAAGSANGKAHTPTAI</sequence>
</entry>
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    <accession>A0A2H3J4H5</accession>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Barry K."/>
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                <person name="Yadav J.S."/>
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                <person name="Ferreira P."/>
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                <person name="Gorecki P."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5 6">MD-104</strain>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="F:alpha-L-fucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
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    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049053">
        <property type="entry name" value="AFCA-like_C"/>
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    <dbReference type="InterPro" id="IPR016518">
        <property type="entry name" value="Alpha-L-fucosidase"/>
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    <dbReference type="InterPro" id="IPR054363">
        <property type="entry name" value="GH95_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027414">
        <property type="entry name" value="GH95_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31084:SF3">
        <property type="entry name" value="ALPHA-FUCOSIDASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31084">
        <property type="entry name" value="ALPHA-L-FUCOSIDASE 2"/>
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            <end position="820"/>
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        <location>
            <begin position="33"/>
            <end position="289"/>
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        <location>
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        <location>
            <begin position="744"/>
            <end position="790"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J4N2</accession>
    <name>A0A2H3J4N2_WOLCO</name>
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            <fullName evidence="17">Nucleoporin protein Ndc1-Nup</fullName>
        </recommendedName>
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    <gene>
        <name evidence="15" type="ORF">WOLCODRAFT_140745</name>
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    <organism evidence="15 16">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">MD-104</strain>
        </source>
    </reference>
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        <subcellularLocation>
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            <location evidence="2">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
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        <property type="protein sequence ID" value="PCH37156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
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            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="235"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="409"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="413"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH37156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="701" mass="77180" checksum="1DCE70442041CF01" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J591</accession>
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        <submittedName>
            <fullName evidence="8">DHS-like NAD/FAD-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WOLCODRAFT_92340</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
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                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sirtuin family. Class I subfamily.</text>
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        <property type="protein sequence ID" value="PCH37412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF10">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
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    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="7">
        <location>
            <begin position="1"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="124"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PCH37412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="263" mass="28276" checksum="A6788E31385BA9E7" modified="2018-01-31" version="1">MSAFRDVLSRSKRIIAVAGAGLSAASGIPTFRGARGMWRKYDAISLATPAAFKENPSRVWQFYHYRRTEALQAQPNAAHHALAMRALDAAAHNLGSTAPTDGPGSVLLEMHGRLFDVVCTAYNCRHRELNFSNPICPALAGTEDLMEAGVVEPDVPLSDPPMCSKCGALAQPGVVWFTEVPHYMDQIYLDKIEELVDAADLCIVVGTSYTVHPAASFASMVQVGGGKVAVFNIDHSDGDDRADFLLLSPCEETLPKALGITMS</sequence>
</entry>
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    <accession>A0A2H3J5F8</accession>
    <name>A0A2H3J5F8_WOLCO</name>
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        <submittedName>
            <fullName evidence="7">FMN-linked oxidoreductase</fullName>
        </submittedName>
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        <name evidence="7" type="ORF">WOLCODRAFT_135431</name>
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        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
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            <taxon>Agaricomycotina</taxon>
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            <taxon>Phaeolaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7 8">MD-104</strain>
        </source>
    </reference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044152">
        <property type="entry name" value="YqjM-like"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43303:SF4">
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    </dbReference>
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    </dbReference>
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        </location>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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</entry>
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    <accession>A0A2H3J5R0</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
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        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH37291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="149" mass="16041" checksum="E20A92E1E2646FC4" modified="2018-01-31" version="1">MSSSQAKAHLPGTASQGDMSTADPLFFPSSSQFPIALDDSQNGADGRDSDSDNDSEEELQLPKPTSISRPWTAAALFRHLSDLASQPLFSPALNTSMSFSLTPMPPKTAPGTAKKKVDDTSDDDDDDDDDDKTETHRIDRTSRSADTYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J657</accession>
    <name>A0A2H3J657_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_95656</name>
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    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH37696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J657"/>
    <dbReference type="STRING" id="742152.A0A2H3J657"/>
    <dbReference type="OMA" id="TYRFWLT"/>
    <dbReference type="OrthoDB" id="194289at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021836">
        <property type="entry name" value="DUF3429"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15887">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15887:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11911">
        <property type="entry name" value="DUF3429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="165"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH37696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="292" mass="30838" checksum="24850448495A21EF" modified="2018-01-31" version="1">MLVRGTASHVSGRPGSQTARQAAQNIKEEVGNSTADLARAIAGGNVFQDAVSTTNRTFLGITNSVAKSVPQPYIVFGLAGGLPYLGATGATIWLARQAGFAATGFAGSIDPGVAITVLDNALNIQTTYGAVMLSFLGALHWGFEFAGFGGHHGYTRLMLGAAPVVYGWSTLALDPVSALIAQWIGFTGLWWADLKATGAGWAPAWYSQYRFYLSVLVGSCIIASLAATSYWGPVGGHGLVSHDLNMIRAERKQKEPEREGYVGGDIEALLAPEDADSYVIVRKKKENGGKQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J7K1</accession>
    <name>A0A2H3J7K1_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">glutaryl-CoA dehydrogenase (ETF)</fullName>
            <ecNumber evidence="11">1.3.8.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">WOLCODRAFT_80387</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>glutaryl-CoA + oxidized [electron-transfer flavoprotein] + 2 H(+) = (2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:13389"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57332"/>
            <dbReference type="ChEBI" id="CHEBI:57378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="EC" id="1.3.8.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="9">Amino-acid metabolism; lysine degradation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Amino-acid metabolism; tryptophan metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.3.8.6" evidence="11"/>
    <dbReference type="EMBL" id="KB467854">
        <property type="protein sequence ID" value="PCH35753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J7K1"/>
    <dbReference type="STRING" id="742152.A0A2H3J7K1"/>
    <dbReference type="OMA" id="HMMNLES"/>
    <dbReference type="OrthoDB" id="435240at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004361">
        <property type="term" value="F:glutaryl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046949">
        <property type="term" value="P:fatty-acyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01151">
        <property type="entry name" value="GCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000003">
        <property type="entry name" value="glutaryl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000006">
        <property type="entry name" value="Glutaryl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000008">
        <property type="entry name" value="Glutaryl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052033">
        <property type="entry name" value="Glutaryl-CoA_DH_mitochondrial"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42807">
        <property type="entry name" value="GLUTARYL-COA DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42807:SF1">
        <property type="entry name" value="GLUTARYL-COA DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0274">FAD</keyword>
    <keyword evidence="4 13" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="16">
        <location>
            <begin position="25"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="15">
        <location>
            <begin position="149"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="14">
        <location>
            <begin position="253"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PCH35753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="410" mass="44960" checksum="D95F7FB1CBD9039E" modified="2018-01-31" version="1">MRCWLCVEYAKYDWEDPLSFESLLTEEEIAIRDTARAFCQARHRTSPFLENLLPRVLEAQRTEEFNHDILPAMGAIGFLGPSIQGYGCAGVSSVAYGLIAREVERVDSGYRSTSSVQSSLVMHPINEYGSDAQKEKYLPRLAKGEIIGCFGLTEPNHGSDPAGMETVAEEVDGGFVLNGAKTWITNAPVADLFVIWARCKWDDKVRGFLLEKGMKGLSAPAIKHKLALRCSLTGSIFIDGVRVGHDALLPKAKGLSAPFGCLNNARFGISWGAIGALEDCIHRTRAYALERHQFQRPLASFQLVQKKLIDAQTEAVLGLHASLQVGRLKDAGKLAPEMISMVKRNNCGKALEHTRRVLDILGGNACSDEYHVGRHVANLQVVNTYEGECTCDIHTLILGKAMTGIQAFAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J864</accession>
    <name>A0A2H3J864_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">DNA damage-binding protein CMR1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WOLCODRAFT_136061</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">DNA-binding protein that binds to both single- and double-stranded DNA. Binds preferentially to UV-damaged DNA. May be involved in DNA-metabolic processes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the WD repeat DDB2/WDR76 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH38131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J864"/>
    <dbReference type="STRING" id="742152.A0A2H3J864"/>
    <dbReference type="OMA" id="DPNTLYW"/>
    <dbReference type="OrthoDB" id="9890280at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000001">
        <property type="term" value="P:regulation of DNA damage checkpoint"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050853">
        <property type="entry name" value="WD_repeat_DNA-damage-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14773">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14773:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 7 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="341"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="421"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="31"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PCH38131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="562" mass="62876" checksum="F1C042B652D7FA55" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J8Q3</accession>
    <name>A0A2H3J8Q3_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WOLCODRAFT_88179</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the helicase family. Dicer subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH38586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="742152.A0A2H3J8Q3"/>
    <dbReference type="OMA" id="TRKNHAY"/>
    <dbReference type="OrthoDB" id="416741at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18034">
        <property type="entry name" value="DEXHc_dicer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.380">
        <property type="entry name" value="Dicer dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038248">
        <property type="entry name" value="Dicer_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005034">
        <property type="entry name" value="Dicer_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14950">
        <property type="entry name" value="DICER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14950:SF37">
        <property type="entry name" value="ENDORIBONUCLEASE DICER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03368">
        <property type="entry name" value="Dicer_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00636">
        <property type="entry name" value="Ribonuclease_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51327">
        <property type="entry name" value="DICER_DSRBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00517">
        <property type="entry name" value="RNASE_3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="21"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="360"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="Dicer dsRNA-binding fold" evidence="11">
        <location>
            <begin position="562"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="domain" description="RNase III" evidence="8">
        <location>
            <begin position="935"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="domain" description="RNase III" evidence="8">
        <location>
            <begin position="1112"/>
            <end position="1259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="517"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PCH38586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1705" mass="191309" checksum="97BAEA6833EA76B4" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J8W0</accession>
    <name>A0A2H3J8W0_WOLCO</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">WOLCODRAFT_65923</name>
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    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Phaeolaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OMA" id="FFKAWLV"/>
    <dbReference type="OrthoDB" id="6132759at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015204">
        <property type="term" value="F:urea transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="DUR"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR46154:SF2">
        <property type="entry name" value="SOLUTE SYMPORTER FAMILY TRANSPORTER (AFU_ORTHOLOGUE AFUA_6G03200)"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH38692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="65" mass="7398" checksum="C0C48126665FC784" modified="2018-01-31" version="1" fragment="single">LIPIPMFLSRYIFSLTFFKAWLVLCVAWLFVAACITSVLPLWESRQGIREIGVGLLKDVLSERVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JAK5</accession>
    <name>A0A2H3JAK5_WOLCO</name>
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            <fullName evidence="3">DUF6533 domain-containing protein</fullName>
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        <name evidence="4" type="ORF">WOLCODRAFT_146790</name>
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        <lineage>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
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                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
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                <person name="St John F."/>
                <person name="Stenlid J."/>
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                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467943">
        <property type="protein sequence ID" value="PCH38941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OMA" id="IAICCEM"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
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        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
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    <feature type="transmembrane region" description="Helical" evidence="2">
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            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="321"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
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            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH38941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="321" mass="35407" checksum="E9438EE018A91E48" modified="2018-01-31" version="1">MLTMQCYSNLESYCISSGCALILYDYSLTLSQEIQLMWNKTSQGNTALFLMNRCVMISIVVSYIFMVPWVDLTNANLPISVAERMIFLVEVATDASLAMWAVVSAFRVYAVSHRCWSLAILTLLLGSAPLATNLTLEARSYFFVDNALVDQLEHLSTSTISKLGLAARICLIISDALVITITWYMLHNHETRLALAQRRLSLSQLLIRDGTLNFTLLLVLNVIGVVLNNLQVTYGFVYLTDAATTVLISRLMLNLRGACFEPDDPTGYQLGTVSSNAPDGTLQFQPQTTGWELHSVASTSDIHTTSTNDPALSGSTPEDRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JAW6</accession>
    <name>A0A2H3JAW6_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
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        <name evidence="2" type="ORF">WOLCODRAFT_146482</name>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
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                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
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                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
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                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
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                <person name="Wiebenga A."/>
                <person name="Young D."/>
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                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467898">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JAW6"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013621893" description="Secreted protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH36953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="277" mass="31084" checksum="3B11F50C7B1D5951" modified="2018-01-31" version="1">MFRLEMQRIGWALCCWLGGETAAVSWIDVEMPHCRLDGTFTLSLLALGGSNVGAAARYRDLVILMGARAAGTSRRSVTPSSELQTPLFSAWQGRCKYHRSERNEGANAPVRAMPRELHRIKVTASRLRRSIVWRCKNCSACTEVPFVQSYLVRKKSGRWPRCGNVQRVASQLRVCIRLADYQIKSHTVEGRSMLVYTGDGGQRHRPRLMDKARARHRKGEGSRACVCVCGDVHNKAAVWMRRWVQSARQYCGGNDVDGSVLHATSVFSWSTVTRPSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JB10</accession>
    <name>A0A2H3JB10_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">T6SS Phospholipase effector Tle1-like catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_133642</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467832">
        <property type="protein sequence ID" value="PCH34858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JB10"/>
    <dbReference type="STRING" id="742152.A0A2H3JB10"/>
    <dbReference type="OMA" id="WMAGEIS"/>
    <dbReference type="OrthoDB" id="3057168at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006616">
        <property type="entry name" value="DM9_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018712">
        <property type="entry name" value="Tle1-like_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840:SF1">
        <property type="entry name" value="TLE1 PHOSPHOLIPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09994">
        <property type="entry name" value="T6SS_Tle1-like_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00696">
        <property type="entry name" value="DM9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T6SS Phospholipase effector Tle1-like catalytic" evidence="1">
        <location>
            <begin position="4"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH34858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="478" mass="52794" checksum="4F09A8C074B78ED0" modified="2018-01-31" version="1">MHPKMLLVFCDGTGNDSNLTDGITAPGGGLGGGGLMRPFATNVLRLSRAVKNTTSDGRLQIVFYQSGVGTEADFGENAVNHTLGIQAMGAAVVYKIRDAYAFIAQNFNEGDEICIFGFSRGAYTARKLSGFIDKIGLLEIENLGYFFEIWRQLVDGEKPNIPRGTRKTNIKCVGVWDTVGSTFNAINTLRIKDTNLPASIDVALHALSLQENRAKLLPTLWTVPLLGLASRGPNSKQLWFPGAHSDVGGGYERHELADIALFWMAGEISSFINIDLDFLRQSGQKRPEPWATSQPHNAYENLKRAEKWPMIEKTRLESGQIARDAQFHRSVLAAPTKLDIPKYMITLNTLKGKFGSNWEPDCPDLNLFEEHCIEEWGKAHIGDQYTCQFQAEAYSNFIPENAIKGGVENNGSVLYVARAPYAVHPGKASSKSGSIPWGYAEIYMKRGYEILTGTTPLKWVKVIGRFDMAQLKGAIPIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JB64</accession>
    <name>A0A2H3JB64_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WOLCODRAFT_128022</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467909">
        <property type="protein sequence ID" value="PCH37053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JB64"/>
    <dbReference type="STRING" id="742152.A0A2H3JB64"/>
    <dbReference type="OMA" id="REWLRIP"/>
    <dbReference type="OrthoDB" id="1274115at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05374">
        <property type="entry name" value="17beta-HSD-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051911">
        <property type="entry name" value="SDR_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976:SF16">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="5">
        <location>
            <begin position="4"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PCH37053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="304" mass="32982" checksum="56B9EED32FBFB08C" modified="2018-01-31" version="1">MSSKIWLITGASSGIGLALAQYVLSQSDRVIATVRSLSKFPSSLRDAGAIPLILDLNGADAEIRKAGKKALEIYGHIDVLVNNAGFGLVSPVEELNLDDLRAQFQTNVFGALALTQALLPSFRERKSGHILNISSIAAFNGFASWSAYNASKAALESFSEALGQEVAPYNIRVLIIVPGFFATNFFQASSQLNLMNPSSVYTDPSQGHGTLEAIPKGHSARGQIGDVVKLSERVFEVVHGTGMAKCLVEGQGGKREWLRVPLGPDCGESMQRKIALLEENVRVFEPIWRSTDVEPERLKLYTYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JB73</accession>
    <name>A0A2H3JB73_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_167289</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467909">
        <property type="protein sequence ID" value="PCH37063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JB73"/>
    <dbReference type="STRING" id="742152.A0A2H3JB73"/>
    <dbReference type="OrthoDB" id="2757853at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="2">
        <location>
            <begin position="2"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH37063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
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        <name type="common">Brown rot fungus</name>
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        <lineage>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Phaeolaceae</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
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                <person name="St John F."/>
                <person name="Stenlid J."/>
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                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JB95"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="94"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH34938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="210" mass="22826" checksum="AD25F79C2453F6DB" modified="2018-01-31" version="1">MPPSQRDFDAVQAIGASAPEALGFLSVIGANICLLLGEMPEINLNFDQNAPSGPPIPFATACFISRMLLRTAEICIKLAQKLLAKTTGPDPPAMNTVNARLERAFNDLDEARLDLYDVEEEVDVGTHQSHISENFDFISCAEFPRTHPERSTGSGLQGHAREFIPLCTEMQTQDRPGDFLEGSSPIHIGTQTQAVVEGFIDMIDNIPSDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JBF1</accession>
    <name>A0A2H3JBF1_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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        <name evidence="2" type="ORF">WOLCODRAFT_141311</name>
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    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Phaeolaceae</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000444">
        <property type="term" value="C:MIS12/MIND type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013950">
        <property type="entry name" value="Mis14/Nsl1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31749">
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH39570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="214" mass="24744" checksum="16328FB929605396" modified="2018-01-31" version="1">MDPGPQRSEDITRISIDTLQDWQRVRANYTAAAMQVFNEEMANSMDDLSGERQVLERYMQQFIQSTFEMTRENLRVNGRNYEDVEMDEEEEPFDEGLDRHIWALSEQSLKWDREIAQKRRETPREVERLIGELLERQREVDADEDASENQEDVDMAGGAIPKADPALEAALERTTKVATRVEAMVAKLQQKVPLQTERTERVQTVAAEVKALKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JBH7</accession>
    <name>A0A2H3JBH7_WOLCO</name>
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        <recommendedName>
            <fullName evidence="2">DUF6535 domain-containing protein</fullName>
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        <name evidence="3" type="ORF">WOLCODRAFT_129435</name>
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        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
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                <person name="St John F."/>
                <person name="Stenlid J."/>
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                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
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                <person name="Pisabarro A."/>
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                <person name="Martin F."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468020">
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    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045338">
        <property type="entry name" value="DUF6535"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20153">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6535" evidence="2">
        <location>
            <begin position="30"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH39612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="161" mass="18167" checksum="8B23717DE88BFBDB" modified="2018-01-31" version="1" fragment="single">MIPSKYNILEHIEQDEKIPNAMRSAPSNELVQKAWNNEKDTVKRRKDEIDNMLVFAALFSAVLTSFIIDSYQSLKPQVPNESTLILRQISVQLSSFISSSGFNNSTSPSFPQLYNVETTEPATSPTYTTVLVNALWFFALVCSLISTSLGIAIRQWLNHHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JBQ3</accession>
    <name>A0A2H3JBQ3_WOLCO</name>
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        <recommendedName>
            <fullName evidence="1">SET domain-containing protein</fullName>
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        <name evidence="2" type="ORF">WOLCODRAFT_155770</name>
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    <organism evidence="2 3">
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        <name type="common">Brown rot fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
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                <person name="Stenlid J."/>
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                <person name="Sun S."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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    </organism>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
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                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
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                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
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                <person name="St John F."/>
                <person name="Stenlid J."/>
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                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1221748"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="15 16">MD-104</strain>
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            <text>ATP + H2O = ADP + phosphate + H(+)</text>
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        <property type="entry name" value="Helicase_ATP-bd"/>
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        <property type="entry name" value="Helicase_C-like"/>
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        <property type="entry name" value="P-loop_NTPase"/>
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        <property type="entry name" value="UBA-like_sf"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
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        <location>
            <begin position="642"/>
            <end position="820"/>
        </location>
    </feature>
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        <location>
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            <end position="1095"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="201"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="249"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="217"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="249"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH33517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="1468" mass="163617" checksum="66C69B773EC64DA4" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JC52</accession>
    <name>A0A2H3JC52_WOLCO</name>
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        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_145729</name>
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    <organism evidence="1 2">
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH33677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JCJ7"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH33677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="85" mass="9460" checksum="7550C729AC921246" modified="2018-01-31" version="1">MLAAYYAKSSPQLSHRKRVVRNKSWVSCAKRSVILLSSFEIRSFAIRRVVRGGLSFPDQLAIHVLQLPGQVMAHLACILGEVPPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JCZ6</accession>
    <name>A0A2H3JCZ6_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">NAD-dependent protein deacetylase</fullName>
            <ecNumber evidence="8">2.3.1.286</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">WOLCODRAFT_116681</name>
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    <organism evidence="15 16">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N(6)-acetyl-L-lysyl-[protein] + NAD(+) + H2O = 2''-O-acetyl-ADP-D-ribose + nicotinamide + L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:43636"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="ChEBI" id="CHEBI:83767"/>
            <dbReference type="EC" id="2.3.1.286"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.286" evidence="8"/>
    <dbReference type="EMBL" id="KB468053">
        <property type="protein sequence ID" value="PCH40120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JCZ6"/>
    <dbReference type="STRING" id="742152.A0A2H3JCZ6"/>
    <dbReference type="OMA" id="ATHSCID"/>
    <dbReference type="OrthoDB" id="420264at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0005634">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="entry name" value="SIRT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
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        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
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    <dbReference type="InterPro" id="IPR017328">
        <property type="entry name" value="Sirtuin_class_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF6">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037938">
        <property type="entry name" value="SIR2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 8 10" id="KW-0520">NAD</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="14">
        <location>
            <begin position="15"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="291"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="334"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="311"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="361"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9 12">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="43"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="53"/>
            <end position="55"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="131"/>
            <end position="134"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11 12">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11 12">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11 12">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="223"/>
            <end position="224"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="247"/>
            <end position="249"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR037938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR037938-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR037938-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR037938-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PCH40120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="376" mass="41577" checksum="3A3203DB3C795A3A" modified="2018-01-31" version="1">MGAEQSKGPYEGSPEVLEARDLPSVAKYMKSPECRKVFVMLGAGASTSAGIPDFRSPEIGMSACCLTQSNLARFDLTHPEAIFEINFFRQNPKPFYALARELLPGRFRPTPTHSFVKLLHDHSLLHTCFTQNIDTLERRAGVPDHKIVEAHGSFANQRCVECRAEYDAVKMRECLKTGTIANCNQCGGLVKPDITFFGESLPEPFHRAVPFLRGADILFVIGTSLQVQPFASLPSLVPEHCPRVLINLEDVGDFGSRSDDVIILDKCDNVVRALAKELGWEEEFDAAWQETENSLDPDEEIPSVVRSGQRNKTEEQQLKDDVEEISEAIAQVAIEPKSDEPADAAPDDQTPVVTGAEEPVLDDKPQSAEEVTKEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JDR6</accession>
    <name>A0A2H3JDR6_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DUF202 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WOLCODRAFT_136834</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB468053">
        <property type="protein sequence ID" value="PCH40380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A2H3JDR6"/>
    <dbReference type="OrthoDB" id="199599at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052053">
        <property type="entry name" value="IM_YidH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34187:SF2">
        <property type="entry name" value="DUF202 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34187">
        <property type="entry name" value="FGR18P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="187"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="DUF202" evidence="8">
        <location>
            <begin position="107"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PCH40380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="215" mass="22956" checksum="A1DB0DECE46DDC09" modified="2018-01-31" version="1">MYSRASDAHASTPGSPSSPLSRVTTLHLDTDSHQIKSGAGKSTPSPYTPSPEGNDNEEQSPEPTIDEARHPSASGPEQRRQRGETLEELGRRLNLSLTLENSGSVARDHLASERTFLAYVRTSLTIASMGVALVQLFTIAGGTNQQLQRYSRPLGATIIVIGLCTLFLGVIRYYAVQNALVKGVYPVARVSAVFVAFALCGIITAVFGILVGNKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JEC8</accession>
    <name>A0A2H3JEC8_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">RNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WOLCODRAFT_22617</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRM U1 A/B'' family.</text>
    </comment>
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        <property type="protein sequence ID" value="PCH34327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="742152.A0A2H3JEC8"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030532">
        <property type="term" value="C:small nuclear ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12246">
        <property type="entry name" value="RRM1_U1A_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12247">
        <property type="entry name" value="RRM2_U1A_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000039">
        <property type="entry name" value="U1 small nuclear ribonucleoprotein A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000029">
        <property type="entry name" value="U2 small nuclear ribonucleoprotein B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10501">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN A/U2 SMALL NUCLEAR RIBONUCLEOPROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="48"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="199"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PCH34327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="273" mass="30362" checksum="03F861C15E26869E" modified="2018-01-31" version="1">MSDLAASPVAPDIMQGVIAAPAPVQAEAMTVTAPAAPAAPAEPEHVSETLYIQNLNEKIKIPVLKASLRGLFKAYGEVVDVVAHSNLRMRGQAFVSFESADIAKKALKEVRGFPLYSKPMQISFARTRSDAVVKRFDAAHFEEHKTRRLEHKKATRYTNPIKRKYRARKLAAEVDGAGAVPASKRPNVQMPDEYLPPNKILFLQNLPESVSKDQLMALFSQYPNLYEVRLIPTKKDIAFVEYMDEGSATVAKDALHNYKLDGENKIKITFARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JEJ5</accession>
    <name>A0A2H3JEJ5_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WOLCODRAFT_23755</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468053">
        <property type="protein sequence ID" value="PCH39965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JEJ5"/>
    <dbReference type="STRING" id="742152.A0A2H3JEJ5"/>
    <dbReference type="OMA" id="AVANPIY"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF236">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PCH39965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="306" mass="33925" checksum="74AD2BA627D7AFED" modified="2018-01-31" version="1">MSAIDENFPPKPKWTANDMPDLTGKVMIVTGGNSGIGKQTVKTLLKRGAKVYMASRNKAKAMKAIFSLQKATGREAIFLELDLANLRSVKKAAAEFQSKEKKLHVLFNNAGVMVPALHELTADGYDMQFGVNVLGHFYFTRLLLPTMMATVQADKEKTRVVTVSSHRHLFTKLNYDALRAGNERNRMGRQELYQMSKYGCVAFAAELARRYGGHGIVSIAVNPGNIRTGISRHAGPVSQVYTRTMFHSTEKGALTQLYAGTAPEAAKMNGKYLIPWARVSEARADAVEPPTGKKLWEWMKEQMAEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JEM3</accession>
    <name>A0A2H3JEM3_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_143038</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468053">
        <property type="protein sequence ID" value="PCH40331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JEM3"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH40331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="378" mass="42680" checksum="03469C4F9F6732A7" modified="2018-01-31" version="1">MSSVFSGTNLDRFIAVHWSAVNELIVYDSIQSPYHHILPHLLGRHVSKISTLTLVGHGGVSETPAQRLLVDPGFLMLVPMFASVTSLVLRNYTLDSYGDLIRLISSFPQLQALSLCGLHLKSQLESLTGAPNLPSTFQRKSHALRLRTLYMYLNPQMTLSILEGLAVTPTCGSLREIEIYGSFEGYFGWSENDHRYAVHTLRSFRIGQDHRRLVLTPNNRRDNSVSFGLIYRENIPSVHRTQVEEISRWQDLWMTIKGILTDPSVKGQLHRIVIHLYLPTTLQATTQGLISLTPQSDHTPVARIGEVTSQRVFDSYTAVTIKMHCAPKYTLSSAERVAVYIKTEGAIQGQLSKWDKRHILELSRSTWNGDWSLVNFEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JEM8</accession>
    <name>A0A2H3JEM8_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WOLCODRAFT_136807</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468053">
        <property type="protein sequence ID" value="PCH40341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JEM8"/>
    <dbReference type="STRING" id="742152.A0A2H3JEM8"/>
    <dbReference type="OMA" id="TRIYYEF"/>
    <dbReference type="OrthoDB" id="7130006at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097176">
        <property type="term" value="P:epoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010497">
        <property type="entry name" value="Epoxide_hydro_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016292">
        <property type="entry name" value="Epoxide_hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661:SF35">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661">
        <property type="entry name" value="EPOXIDE HYDROLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06441">
        <property type="entry name" value="EHN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001112">
        <property type="entry name" value="Epoxide_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0058">Aromatic hydrocarbons catabolism</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epoxide hydrolase N-terminal" evidence="5">
        <location>
            <begin position="5"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="312"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001112-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF06441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PCH40341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="403" mass="44799" checksum="5FAB301132A7A082" modified="2018-01-31" version="1">MSEASFTLNVPDAEIELLQKKLALTRLPDELDEAGWDYGVPLADIRRLVARWQDGFDWRKAEAEINHLPQFTRDIDVDGFGTINIHYIHQKSIVPNAIPLLFVHGWPGHFLEVRKMLPMLTEASPDHPSFHVVAISLPNFGFSEAPKKKGFAGTQYAEVSNKLMLSLGYNEYVVQGGDWGHLVAKTLAVRYGHKSVKAWHTNMAAAGPPSFWTHPFRFLAFLVTPWTAAEKAGLAHSQQFELKGSGYFKEQSTQPQTIGYNLADSPVGLLAWIYEKLVQWTDGYPWEDDEVLTWISVYWFSRAGPAASVRIYYEVMGSAGVGAIVGTKYSSIPLGLSYFPKELMVVPRLWSRTIGNVVYESEHQSGGHFAAHEQPEALAADVRSMFGKGGPAFGVVPGKNGYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JEP0</accession>
    <name>A0A2H3JEP0_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WOLCODRAFT_27688</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
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                <person name="Eastwood D.C."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <location>
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        <ligand>
            <name>substrate</name>
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            <position position="76"/>
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    </evidence>
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    </evidence>
    <sequence length="309" mass="33805" checksum="2BC742E0B012142B" modified="2018-01-31" version="1">MAGPSIKLNNGVEIPVLGLGTWQSPPEQVTNAVEYAIKEAGYRHIDCAWMYGNEKEVGEGIRRSGVPRSEIFITSKLWCTQHNQVEAALDDTLANLGTDYLDLYLIHWPIHLNPNGNHPKLPTLPDGSRDILRNWKLKDTWAQMEAVLKKGKVRAIGVSNFSERVLEQEILPYAEIVPAVDQLEIHLYNPQHKLLAYLRSKGIVPQAYSPLGSTGSPLLADETAAAVAAKHGLQPADVILGYLVAKDIVTLPKSVTPARIASNYAGALAAASKLTKEDVELLDGVAASGKQKRLIMPPWGVDLGFENWP</sequence>
</entry>
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    <accession>A0A2H3JEY1</accession>
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        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
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        <name evidence="6" type="ORF">WOLCODRAFT_166169</name>
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    <organism evidence="6 7">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
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                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
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                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD-104</strain>
        </source>
    </reference>
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    <dbReference type="InterPro" id="IPR052462">
        <property type="entry name" value="SLIRP/GR-RBP-like"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MLLE"/>
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    </dbReference>
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    </dbReference>
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            <end position="189"/>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="830" mass="89306" checksum="FF1CB30612A36AC8" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
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        <lineage>
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH40800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JEZ8"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH40800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="175" mass="19346" checksum="A97B17D8F18F6708" modified="2018-01-31" version="1">MYSMGLAVAAALEREELDNMQLLERRIDIPDDYPDWAKLPLNDLNMKHAKFAEKFELLLNSLPAPSEFAKTDMTEDQDQDRTAGKDQQQCRKSGRLEKSRSTWAPVLGGEEEQPPTARQDVRLYGEEAQAEGRAQEKQRMAANSRKASKTAAGTVAYDDGSAGLGIRDAGIKTGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JFU7</accession>
    <name>A0A2H3JFU7_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_143220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH40781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JFU7"/>
    <dbReference type="STRING" id="742152.A0A2H3JFU7"/>
    <dbReference type="OrthoDB" id="2792702at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="2">
        <location>
            <begin position="191"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH40781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="314" mass="34423" checksum="7D82E7FBADA263F3" modified="2018-01-31" version="1">MPATPDEVLGPGLIGLIFGIVLYGVTCAQVTYYCARYCARHRDELGHVKRLVAILWVLDTATTTAAIVAGWDYLVTMHASASATTILVRAVAIEYLFGVCTDLRDRTAKCIDLTFVQAIVTLIAQCCYMYSICRLTMRKWYCIPLTITMLMSALTSCACGIASAYIGFSDHEMPGIFVKTKTTAVLQILAATVTDLYITISLTLILRGHRTGFRNTEAMINKLTVYIINRGILTTLIPIGQTIAYTTAPVQVTAWAAFHVPGSKVYVNSLIAMINARGSINQRQTVEDHLTTMFFEAPPPSQIALADSRRGAKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JG25</accession>
    <name>A0A2H3JG25_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycoside hydrolase family 30 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WOLCODRAFT_28705</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 30 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467887">
        <property type="protein sequence ID" value="PCH36648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JG25"/>
    <dbReference type="STRING" id="742152.A0A2H3JG25"/>
    <dbReference type="OMA" id="NDAAGYP"/>
    <dbReference type="OrthoDB" id="2160638at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004348">
        <property type="term" value="F:glucosylceramidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006680">
        <property type="term" value="P:glucosylceramide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001139">
        <property type="entry name" value="Glyco_hydro_30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033453">
        <property type="entry name" value="Glyco_hydro_30_TIM-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11069">
        <property type="entry name" value="GLUCOSYLCERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11069:SF23">
        <property type="entry name" value="LYSOSOMAL ACID GLUCOSYLCERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02055">
        <property type="entry name" value="Glyco_hydro_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013615077" evidence="5">
        <location>
            <begin position="19"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 30 TIM-barrel" evidence="6">
        <location>
            <begin position="69"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PCH36648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="497" mass="54720" checksum="8379FC06FD136A13" modified="2018-01-31" version="1">MLLRALTSSLALALPIAAQQIYDIWSTTWQRDYLFTYTNLSPNPINFVTPGSTGTSDIVVTDSNVYQDIAGFGAALSDSSAKILSELKSTNSDTYWDLLNYLFDPTDGADAAGFSYLRVPLGASDFSDTVYSFDDTSGDTPLNDFNINAAPSYLYEVLQDILSINNILKIHVVPWSPPGWMKDGGSMLGGKLWTSLADVYANYLLKCLQGYQSMGIPVWAIGIQNEPQNSNPTYPTCTIDAYWEGQIGLQLRTLMDNNGFSDVIIIGYEHNWDDAGAYPVDLMEDAGSAFAGVSFHCYAGTVSDQETFYNAYPNKNIYFTECSGTFGSDWWSDIKWYMNNVFIGSVNYWSQSGAMWNLVLNGEGGPKLPGTNSCSGDPCRGVVTVNSNGTYNYNQEFYAIAQANKAILPKDTGGPFGQRIQVAVNGNQNLLVGAYVTGRTDPTAWLRYSIVVLNQNDESNGSWDPVDIEATIEFRGQQATYTFPVGVTTLWWYAEPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JGF1</accession>
    <name>A0A2H3JGF1_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidase C14 caspase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WOLCODRAFT_140997</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C14B family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467943">
        <property type="protein sequence ID" value="PCH38923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
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        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050452">
        <property type="entry name" value="Metacaspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104:SF30">
        <property type="entry name" value="METACASPASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104">
        <property type="entry name" value="METACASPASE-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="365"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C14 caspase" evidence="5">
        <location>
            <begin position="16"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PCH38923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="384" mass="41913" checksum="F614AA3E9EAE3CF8" modified="2018-01-31" version="1">MQVNDYRAAHSCRIFVLLVGVDTYSDEDIHDLSGCINDCKNFEAFLLENLGVPKRNIRSLHNEAATRGAILGAIDDHLFKNEEIVKGDVMIVFFAGHGSQVPAPECWTPQGSEVETIRPYDEGMQKDGTLVYGIPDRTIAILMAQLSRRKGDSIVTIFDCCFSGGLSRGTATVRSSVANDELASLPADLDQDIWDRDPDALHAILSNSTNSFLNSEVTSHVMLAACHETESAHETTKEGVRCGLFTHNLLKALRGHAIGAITYDQLIQKLPKLRRQSPQCVGVHKHRVLFKATERGTIIGGAGLSQLGEGSAGPSVWAGERKISPRVSAVAFPPSPVHYQPAVAGAFSNDAVFFSTLPPHRFLCVFHLVFCILWYAALYLLLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JGR5</accession>
    <name>A0A2H3JGR5_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WOLCODRAFT_156608</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467865">
        <property type="protein sequence ID" value="PCH35904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="742152.A0A2H3JGR5"/>
    <dbReference type="OMA" id="RFRANAC"/>
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    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005162">
        <property type="entry name" value="Retrotrans_gag_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032567">
        <property type="entry name" value="RTL1-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503">
        <property type="entry name" value="LDOC1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503:SF22">
        <property type="entry name" value="TRANSPOSON TY3-I GAG POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03732">
        <property type="entry name" value="Retrotrans_gag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="5">
        <location>
            <begin position="223"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="171"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="235"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="73"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="171"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="184"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="237"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PCH35904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="306" mass="35423" checksum="982D2A9058C0B873" modified="2018-01-31" version="1">MQNFINQCNSWFTMYETSFQNDVQRVIFILSYISGKGKTGQWKQNYHRVHTDPMTRRFFPPSLVQFDADFQKAFGAVQEIQKARRQILKLEQDKKDIDDYITEFNNMAGKAQYDRYSPDGNAILVTLFEKGLPEHTTRYIIGMRPMPDNIDAWQEAASYYENTYRIFRKQDRGTPAKKKEWRSNAPQHSGSVSTPQTTPKDPSAMDVDRLTAEERQDHITKGKCFNCHQPGHLSRNCPKKKKGTIRPRGKARKVEESSPEPEVIIEETSDEETEYITANRAVTAIRTLKAKNPELLSQLLEETDFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JH60</accession>
    <name>A0A2H3JH60_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">FUN14-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WOLCODRAFT_64834</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FUN14 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH38109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JH60"/>
    <dbReference type="STRING" id="742152.A0A2H3JH60"/>
    <dbReference type="OMA" id="FYELTFG"/>
    <dbReference type="OrthoDB" id="163794at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007014">
        <property type="entry name" value="FUN14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21346">
        <property type="entry name" value="FUN14 DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21346:SF10">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04930">
        <property type="entry name" value="FUN14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PCH38109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="210" mass="22336" checksum="1D3A3AA942AEB0BE" modified="2018-01-31" version="1">MSASSSIPALSKHAIPRTHFFTSARTLSLEAKSAHTLPSRDVLSWGKLAGVASVGLCLSILAAPMIFCEPAVARTSPYPISQPSPSAPFQSPEGLPPPPSSNVNYLELTFGTAAGVCAGVFVKKGAKAVAFVLGGVFVLLQYLGSLSLVRVDWVRASSRFENLFYRTDASGQRRAPTVGSLFRWIIDFLTADFQERASFVAGFALGLRIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JIH6</accession>
    <name>A0A2H3JIH6_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WOLCODRAFT_110061</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467931">
        <property type="protein sequence ID" value="PCH37538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JIH6"/>
    <dbReference type="STRING" id="742152.A0A2H3JIH6"/>
    <dbReference type="OMA" id="ISCVTIR"/>
    <dbReference type="OrthoDB" id="6509908at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF177">
        <property type="entry name" value="RIBOFLAVIN TRANSPORTER MCH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="62"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="100"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="197"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="240"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="302"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="332"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="367"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="401"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="241"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PCH37538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="441" mass="47207" checksum="A59AEE1413CB7EC0" modified="2018-01-31" version="1">MDCDPEKKGGETAQNQEVSPVTAPVSDFPEGGLQAWATVWGGFFAFVATFGVVNAYGVFQDYYSATLLANSSSSTIALIGAIQLFFLYSGGTVVGRVYDAYGTGVLIPLGSFFIVFSLMMVSLVQPDKPYQLFLAQGLGFGLGLACIFNPTMAVAGHWFKRRRAYAIGVIASGSSVGGVFIPIMLQRLIPMVGFPWAVRAVAFICLGCLTIACLTIRTRLPPSRTISLRGLVDLNGFRDWKYVCAGIGGFLVFYAIFIPYFYIQIYATFRGVPNDYAIYLLPIINAFGLPSRIFPGLMADRWGCLTVLVPSTLIASLFTLALWLPARNATEITAFAAMYGLFTGAFVSLLPAYIYTISPIEVYGARLGALYLLVGIANLVGTPTAGAFLTTVNQAGFDGLIVFTGVLLAAGSSILGVVGIVTAIKTRREAKAATSQYTAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JIL8</accession>
    <name>A0A2H3JIL8_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongator complex protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WOLCODRAFT_89239</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD-104</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat ELP2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH41385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JIL8"/>
    <dbReference type="STRING" id="742152.A0A2H3JIL8"/>
    <dbReference type="OrthoDB" id="27911at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037289">
        <property type="entry name" value="Elp2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44111">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44111:SF1">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="7 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="49"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="150"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="258"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="375"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="578"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="623"/>
            <end position="654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
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    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="3"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="95"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="194"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PCH36664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="287" mass="30861" checksum="922DD536DADF40CF" modified="2018-01-31" version="1">MDASTVNELTAGSLGGAAQVIVGQPLDTIKTRAQVAPKGMFKGPMDILAQTVRKEGFFALYKGMASPLVGIAGVNSLLFAAYGVSKRLISPFPQLSLTEIAAAGAMAGAINAILASPVEMFKVRMQGQYGSPSDKRLRAVVGEMWQQWGFRKGIMRGYWITVAREIPAYAGFYSAFEFSRRKFAEKYGSQLPVWALLASGSTGGIAYWLACYPLDVVKSRVQLRATPPSGTPVQYIAHELRTIVAESGMSGLFRGLSPSLLRSIPAAASTFAAFELTREYLREATGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JJ49</accession>
    <name>A0A2H3JJ49_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Citrate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WOLCODRAFT_88358</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the citrate synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468053">
        <property type="protein sequence ID" value="PCH39903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JJ49"/>
    <dbReference type="STRING" id="742152.A0A2H3JJ49"/>
    <dbReference type="OMA" id="GKWEANT"/>
    <dbReference type="OrthoDB" id="8017587at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046912">
        <property type="term" value="F:acyltransferase activity, acyl groups converted into alkyl on transfer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="entry name" value="Citrate Synthase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="entry name" value="Cytochrome P450-Terp, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739">
        <property type="entry name" value="CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739:SF15">
        <property type="entry name" value="CITRATE SYNTHASE 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00143">
        <property type="entry name" value="CITRTSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PCH39903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="450" mass="49647" checksum="FD8E191A300FD625" modified="2018-01-31" version="1">MATVESHGLAPVQTLFDVIEARLPSRLELFSKLTKEFSDVTLHNMTVGNVMGGMRGLPCILWEVSGTDKAGITYHGKSLRELQEVLPKWRGSDQTSPEAMIWYLYSGSIPNRAELEQFAADLAARAEVPAEVEEFCDSLSPDISSTAQLIMCLTVWANHSKFSDALMSGAPRNKLWRYALEDALDSHVGTPLISARIYANKYRDGRDRTAPLNPLGDIAENFAIRMGRKGDTDFTELIRMYWSLHMDHGANVSAHTMRLSSSAWTDPYLTLASGLISGTGVLHAGAIMQALRYNQAMVAAIGPEPSPEAVETYICRTLEKGHVVPGYGHALLRSADPRLEPITRFINTRPITDSGSSEQGKMLRLIAHNSTIVPDILRRHVPRMKSTAPNVDSLSGCLMYAHGLDIDFILLVMGCSRGMGFMAQYVWDRALGLPIERPLSVTMDQIMAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JJ97</accession>
    <name>A0A2H3JJ97_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_135864</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH37818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JJ97"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH37818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="209" mass="22481" checksum="26283EC1E1697C61" modified="2018-01-31" version="1">MSAETARRRASQKLATSAGRRVTFPVTAPRMRPLGVTEAPPRARSATVAARLGTLPATAPRRPAPVGTATHTVPLAGTRTSNAPATPAAVLDTCRVIACRRPSATTALASAISAKTARNLSGGHATPAVRKDTSRATAPRPTLRPRLRYRLISCSFVLLYFPLRLYSSTRCRCFALLSVSRDVCTSGTLYRKSELMSRNARSSEIHQRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JJA6</accession>
    <name>A0A2H3JJA6_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alcohol dehydrogenase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_167666</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
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                <person name="Lundell T."/>
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                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
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                <person name="Ohm R.A."/>
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                <person name="Stenlid J."/>
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</entry>
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            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
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                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
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                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
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                <person name="Kumar T.K.A."/>
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                <person name="Murat C."/>
                <person name="Nagy L.G."/>
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                <person name="Ohm R.A."/>
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                <person name="Wiebenga A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">MD-104</strain>
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    </dbReference>
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        <location>
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    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
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    <evidence type="ECO:0000259" key="1">
        <source>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="99" mass="11277" checksum="E3FEFBE1EE317D85" modified="2018-01-31" version="1" fragment="single">LASQTIEVHTIIKISPILLFSSREYEEHGRHTVLDHYTFNVNKSPESCALQSETGSLFNYSKKPNVSYTLDVSTESIKYTAICCIDKDEELCIFYGHNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JMY5</accession>
    <name>A0A2H3JMY5_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_122141</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468146">
        <property type="protein sequence ID" value="PCH43536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JMY5"/>
    <dbReference type="STRING" id="742152.A0A2H3JMY5"/>
    <dbReference type="OMA" id="WANIEET"/>
    <dbReference type="OrthoDB" id="2322499at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="40"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH43536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="647" mass="74301" checksum="171FB0792D1B9C66" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JNS4</accession>
    <name>A0A2H3JNS4_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF1752-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_85564</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467987">
        <property type="protein sequence ID" value="PCH39378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JNS4"/>
    <dbReference type="STRING" id="742152.A0A2H3JNS4"/>
    <dbReference type="OrthoDB" id="515401at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031930">
        <property type="term" value="P:mitochondria-nucleus signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006808">
        <property type="term" value="P:regulation of nitrogen utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013860">
        <property type="entry name" value="AreA_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053043">
        <property type="entry name" value="Ras-cAMP_regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28014">
        <property type="entry name" value="NEGATIVE REGULATOR OF RAS-CAMP PATHWAY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28014:SF1">
        <property type="entry name" value="NEGATIVE REGULATOR OF RAS-CAMP PATHWAY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08550">
        <property type="entry name" value="GATA_AreA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitrogen regulatory protein areA GATA-like" evidence="2">
        <location>
            <begin position="101"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH39378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="129" mass="14080" checksum="4E398BCAED4FA1D0" modified="2018-01-31" version="1" fragment="single">MVYPLCQEGICFILSPRPPPGASSSPTLLPACPACPPQSDTARRRFSPVQGSSSLPRRPAPATFLSLCTSSPLMAPFAAPVLSVAADVVQELDGEDALYGLWALFTKCKESLKDGRRLENISWRLWYRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JP36</accession>
    <name>A0A2H3JP36_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WOLCODRAFT_55641</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD-104</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468146">
        <property type="protein sequence ID" value="PCH43946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JP36"/>
    <dbReference type="STRING" id="742152.A0A2H3JP36"/>
    <dbReference type="OMA" id="FIGNTHQ"/>
    <dbReference type="OrthoDB" id="2802867at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF5">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PCH43946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="120" mass="14296" checksum="5A76E7EC470CE6BB" modified="2018-01-31" version="1" fragment="single">LPLGPNPLLLLRNVHQVPMEHQCKMSHHWAKQYGDVLYLWLFSKSAVVLSSIQAAHDLLEKRSSKYSHRPHFMLIYNMMGWHSNLALMPYGDRWHLHRKWFHSSFNEGKVVEEYCSIQQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JPZ6</accession>
    <name>A0A2H3JPZ6_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">D-xylose 1-dehydrogenase (NADP(+), D-xylono-1,5-lactone-forming)</fullName>
            <ecNumber evidence="3">1.1.1.179</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">D-xylose-NADP dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WOLCODRAFT_26576</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>D-xylose + NADP(+) = D-xylono-1,5-lactone + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22000"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15867"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.179"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.179" evidence="3"/>
    <dbReference type="EMBL" id="KB468157">
        <property type="protein sequence ID" value="PCH44242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JPZ6"/>
    <dbReference type="STRING" id="742152.A0A2H3JPZ6"/>
    <dbReference type="OMA" id="WHFEADE"/>
    <dbReference type="OrthoDB" id="2129491at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047837">
        <property type="term" value="F:D-xylose 1-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050984">
        <property type="entry name" value="Gfo/Idh/MocA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055170">
        <property type="entry name" value="GFO_IDH_MocA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22604">
        <property type="entry name" value="OXIDOREDUCTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22604:SF105">
        <property type="entry name" value="TRANS-1,2-DIHYDROBENZENE-1,2-DIOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22725">
        <property type="entry name" value="GFO_IDH_MocA_C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="9"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="GFO/IDH/MocA-like oxidoreductase" evidence="7">
        <location>
            <begin position="150"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00042988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PCH44242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="371" mass="40745" checksum="4BC440B68E72D9EA" modified="2018-01-31" version="1">MASAQPFVLRWGIISTGRIAMEFIKDCLVDPTTRGTTDVVHKVIAVGSRNGNVQKATEFIEAYGAGQAIKAYGTYEEVYADKEIDAIYIGSPHTQHYENALAALQAGKHVLCEKATTSNAAELRHLLSVAKGKGLFFMEAMWTRFQPLVKEVKRIAEEGPLGDPVVLHADLAHDFQVDTLPLSHRIINPQLGGGALLDLGPYPMIWTVLALYEHPSNKKALPTSISASIVKSPITGVDSSTSWTVNFTSTLRAQAILSCSITLPSAPFGATIRYRGGNIFIPNPIFKPSHFTVQYFDKPGSGVVVREEKRVFNYVGGGWHYEADEVARCVRDGKLESDLWGHDKSLLLMDTFDEVRRQGGYKLPDGVEKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JQY6</accession>
    <name>A0A2H3JQY6_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_149367</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH38427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JQY6"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH38427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="79" mass="8986" checksum="DB4651BA5F703763" modified="2018-01-31" version="1">MPPKVTKARRRYCSGDYYKNHSRLLPNHQENIRWVYLSNTLPDAKKPRKTTSKTAKPSTKSRGKAAAPAPQQGFELFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JR66</accession>
    <name>A0A2H3JR66_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA glycosylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WOLCODRAFT_165303</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
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                <person name="Barry K."/>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
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                <person name="Barry K."/>
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        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21032:SF0">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 11"/>
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    </dbReference>
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        <property type="entry name" value="DUF4187"/>
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    </dbReference>
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        <property type="entry name" value="DUF4187"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="2">
        <location>
            <begin position="78"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="76"/>
        </location>
    </feature>
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        <location>
            <begin position="106"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH41429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="359" mass="39856" checksum="0B4DC2DEBF7178B3" modified="2018-01-31" version="1">MADEEDDYLSDKFLLDTASAPSAPKTYAERRKEAQRQAVAKNEQNRKKSRRQLELESREEGLSKSLFERAKDEEASGQKNKALAMMMKMGFKPGETLGRKDDDESSTSVGASTSNTAVAQRDTASSEPSDRPRSGIGHRAEPLPLNEWAGARKGIGLGKRAASPGASERLAKMAKMAEESDHASFRDRARQEYEERRAQGRLAPAQLTCANLDEKAGIEFNVLWLNPENPEAFPEGLVDVLEDAGLAAALQRQQADHSIEGRLRARMRADALQPLATSLDDDATGAAQEDALALRKSPYSDDDIQEATQFLRLNARDRLQLVLDYLRQKYAYCFWCGTQYDDQEDMANNCPGPEEEAHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JRP0</accession>
    <name>A0A2H3JRP0_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-oxoacyl-[acyl-carrier-protein] reductase</fullName>
            <ecNumber evidence="2">1.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WOLCODRAFT_105735</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a (3R)-hydroxyacyl-[ACP] + NADP(+) = a 3-oxoacyl-[ACP] + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17397"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
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            <dbReference type="EC" id="1.1.1.100"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
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        <property type="protein sequence ID" value="PCH44830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032787">
        <property type="term" value="P:monocarboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SDR_fam"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="3-OXOACYL-[ACYL-CARRIER-PROTEIN] REDUCTASE FABG"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PCH44830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="274" mass="28936" checksum="1BE2978EC0AAFF9E" modified="2018-01-31" version="1">MAQIASSRRVAVITGAAHGIGKSTALRLAGDGFKVAVNDIDRKKNQLQDLVSEIREKGGQAIAVPADVSLEPDVQSMCAQVVDTMGGIDVMVANAATFQGSGRPLHESSTEDFDRIMAINLRGVMLSYKYVAQQMLKQGRGGRIIGASSVAGKQSEANASAYCAAKFGLRGLTHSLALEVFKHGITVNSYAPGFILTEMSCLPDDAHNGGPGSTILKLLNLSPDTPKAWPDVIASLISYLAKPESYYITGQYNCTSAHSAALIQQVGARSNSHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JS96</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468009">
        <property type="protein sequence ID" value="PCH39524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JS96"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH39524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="99" mass="11786" checksum="57A9A5825356A675" modified="2018-01-31" version="1">MITQYVCYLYGLFLLITFDLQLRKIHARNNRAWPGVYLFQDYSKELCHRHYIQAGVDEFIILIFPIFLTSSLLFSVSVLPLISMQFLHLAEHHHIVYKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JSJ2</accession>
    <name>A0A2H3JSJ2_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_151825</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
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                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
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                <person name="Syed K."/>
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                <person name="Wiebenga A."/>
                <person name="Young D."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OMA" id="IADHEIW"/>
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    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH41769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="126" mass="14326" checksum="67C5A441C5967D68" modified="2018-01-31" version="1">MHAYKNLISVLDDFCVDIMRQKKARKHGIGSIILSEIAHVSDEPLEPAHMLVKLLLPTASVITNAIPAHVYMIGHLPDARYDTSFVSWKDPEEIADHEIWASREAVQLRLDMMSERCCNIYPPTPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JSL9</accession>
    <name>A0A2H3JSL9_WOLCO</name>
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        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">WOLCODRAFT_155148</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
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                <person name="Stenlid J."/>
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                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468168">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OMA" id="NEGRCHI"/>
    <dbReference type="OrthoDB" id="2322499at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH45142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="504" mass="58041" checksum="3786E6FA6936FE43" modified="2018-01-31" version="1">MPIDILLDICRHLHPKDVLVLARSSKAFREILMSHTATSAWRDSRDNVPGLPDCPTHMSEPAYADLLFMKYCQSCLQPHAGTPFWDFHARYCKRCEADTTISLVDIKLPPRLLSIASEVLNVNEGRCHIPHVVKLMHEWNSLQEDSEAQDRYIEMRRTTIQDMKKSVRKMQQAISDNKRVDVMVDRLLAFGSHITSLPRDASKLYQPTLSDFAAMPEFRQDIECPNDTKLTEDTFVKFRAQLHNMIQRWQRYNASILALKLPVDEHILKAQGTGVLLLAMVCFDCTRCHQLLRFPEILAHDPSCFGQLTRDSLYKQALTWAGCCAPWSEQRFRVSPSFKRCEEIIRICRLDPFKTTRHDMDALDVRVCCDEGDLTRVLTWDKAMEEEHQRAVKGSAHATPVAAPQWRRATEAELSRARKAELAAARRLRKMHALQPYWCCAHCTHGLWSAGSIRAHLRTEVYANDDPTSLFLHPDGSRKMHGHVILEKPGFETEAGDRIEFWEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2024-01-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JT24</accession>
    <name>A0A2H3JT24_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_158770</name>
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        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
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        <lineage>
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            <taxon>Phaeolaceae</taxon>
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        </lineage>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
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                <person name="Martin F."/>
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                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467976">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JT24"/>
    <dbReference type="STRING" id="742152.A0A2H3JT24"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH39227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="155" mass="17412" checksum="DF67B545682031C3" modified="2018-01-31" version="1">MANSHHQLPDHCKDDPICFPMLTYPQVLLKGAPNASRLPPTPKLCGDYISMSLMPSVSYVQSTISSNFTLLMTSNSLVPSLLFDNQNSPMCWSEDSMLSTNAFSMQLKKLYLFITILETKVQSEDQDKDWKDIQWDAPCVGVLVKCHGNHRATTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JU29</accession>
    <name>A0A2H3JU29_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WD40 repeat-like protein</fullName>
        </submittedName>
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    <gene>
        <name evidence="4" type="ORF">WOLCODRAFT_118730</name>
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    <organism evidence="4 5">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Phaeolaceae</taxon>
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    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
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                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH41338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A2H3JU29"/>
    <dbReference type="STRING" id="742152.A0A2H3JU29"/>
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    <dbReference type="OrthoDB" id="25131at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
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    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039328">
        <property type="entry name" value="WDR89"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22889">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 89"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22889:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 89"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="320"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PCH41338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="382" mass="40888" checksum="B7982F5B47206189" modified="2018-01-31" version="1" fragment="single">MSLFDAPSLRNVSAPIKSTSLQSGAYVLSIVSLPAHYAVSASSPDNAIHLFDKSRLRSVRTIPGHQSAITTLRSPQKFAGTSAPILISSGKDGVVKAWDGRSPAAGPMMTASTAGRPCALLSCDVSTNGMIIAAGTELQGDDASVVYWDPRYPAAPLRTHSSTHSDDITAVHFSRVNNSTVLTISSDGLLCTSNADEPDEDEAGLHVGNWGCSVAQAGWVYGRSGSPGIWASSDMETFSAWSGELDKVQDVDIRHPSIHRQDLTWVTDYLIGCHNISTIPLDMDNDLSMFVGSNEGDIALLTRPTFSDPNAPWILSHMWTTGHTEVVRSVLWDEENNILLTGGEDSRLNAWLSPSFVSGVTTDSAVKRSSDDAMDVDVKEPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JUD9</accession>
    <name>A0A2H3JUD9_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">WOLCODRAFT_75349</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the UPL family. TOM1/PTR1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="4"/>
    <dbReference type="EMBL" id="KB468146">
        <property type="protein sequence ID" value="PCH43593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="742152.A0A2H3JUD9"/>
    <dbReference type="OMA" id="ADEMKYG"/>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14297">
        <property type="entry name" value="UBA2_spUBP14_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000004">
        <property type="entry name" value="E3 ubiquitin-protein ligase HUWE1, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000001">
        <property type="entry name" value="E3 ubiquitin-protein ligase NEDD4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1750.10:FF:000003">
        <property type="entry name" value="E3 ubiquitin-protein ligase UPL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010309">
        <property type="entry name" value="E3_Ub_ligase_DUF908"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010314">
        <property type="entry name" value="E3_Ub_ligase_DUF913"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050409">
        <property type="entry name" value="E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025527">
        <property type="entry name" value="HUWE1/Rev1_UBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254:SF67">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE HUWE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254">
        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06012">
        <property type="entry name" value="DUF908"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06025">
        <property type="entry name" value="DUF913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22562">
        <property type="entry name" value="UBA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14377">
        <property type="entry name" value="UBM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="7 11" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBA" evidence="13">
        <location>
            <begin position="1288"/>
            <end position="1328"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="14">
        <location>
            <begin position="3307"/>
            <end position="3642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="205"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="743"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="975"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1328"/>
            <end position="1388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1712"/>
            <end position="1749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="2032"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="2466"/>
            <end position="2577"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="2724"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="2949"/>
            <end position="3012"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="223"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="765"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="978"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="999"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="1330"/>
            <end position="1341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1342"/>
            <end position="1352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="1353"/>
            <end position="1362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
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            <begin position="1713"/>
            <end position="1729"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1739"/>
            <end position="1748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="2039"/>
            <end position="2063"/>
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    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="2077"/>
            <end position="2153"/>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
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            <end position="2176"/>
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    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="2185"/>
            <end position="2199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="2466"/>
            <end position="2496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="2497"/>
            <end position="2518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="2521"/>
            <end position="2536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="2563"/>
            <end position="2576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="2733"/>
            <end position="2742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="2976"/>
            <end position="2988"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="2990"/>
            <end position="2999"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="11">
        <location>
            <position position="3609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PCH43593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="3642" mass="401445" checksum="C566CD1D28063E88" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JUG0</accession>
    <name>A0A2H3JUG0_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_16468</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468053">
        <property type="protein sequence ID" value="PCH40354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JUG0"/>
    <dbReference type="STRING" id="742152.A0A2H3JUG0"/>
    <dbReference type="OMA" id="MEPGWIM"/>
    <dbReference type="OrthoDB" id="41238at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990189">
        <property type="term" value="F:protein N-terminal-serine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008999">
        <property type="term" value="F:protein-N-terminal-alanine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051908">
        <property type="entry name" value="Ribosomal_N-acetyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43441:SF5">
        <property type="entry name" value="FAMILY ACETYLTRANSFERASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43441">
        <property type="entry name" value="RIBOSOMAL-PROTEIN-SERINE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="72"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH40354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="253" mass="28649" checksum="8CBA405ECBDA9DCF" modified="2018-01-31" version="1">MSFVNLYKPPEPQPPLDLIEQYGPDPYDVNFAFPLHLETLESNRVRRLTPFIPSLHGQLYWDNVSSSYQELFRYYPIIHNSLAEFLAYIEKYYRSNPEFILLAIIDKTRPDLAHPELGGGSMAGVIALLRTSSAKLCTEIGYVLVFPAFQRTHVATHATGVLLQYCLRLPSESPPGLGLRRIQWISHPKNEASLRLARRMGFKGEGTLRWTWILPEEIADGDAPRGSDPCAPCRGLHSVVLAVCWDDWEQGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JV61</accession>
    <name>A0A2H3JV61_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">D-aminoacid aminotransferase-like PLP-dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WOLCODRAFT_26242</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD-104</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468146">
        <property type="protein sequence ID" value="PCH43853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JV61"/>
    <dbReference type="STRING" id="742152.A0A2H3JV61"/>
    <dbReference type="OMA" id="WLYGDQH"/>
    <dbReference type="OrthoDB" id="1732691at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004084">
        <property type="term" value="F:branched-chain-amino-acid transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005786">
        <property type="entry name" value="B_amino_transII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825:SF44">
        <property type="entry name" value="BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825">
        <property type="entry name" value="SUBGROUP IIII AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PCH43853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="141" mass="15195" checksum="79C2556A91E2B85C" modified="2018-01-31" version="1">MNAFAVFEQPDGVIELATPPLDGLILPGITRDSVLALAREHQYGKSSIPDLPEQSRFIVSERQIPMEEVKKAALAGTLVEFFGTGTAAVISPVSRIGYLGEDVHIPTGPDGMGPVTRPLWKRLVDIQTGVLPHPWSVAVTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JW83</accession>
    <name>A0A2H3JW83_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcriptional regulator of RNA polII, SAGA, subunit-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WOLCODRAFT_76347</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB468157">
        <property type="protein sequence ID" value="PCH44243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JW83"/>
    <dbReference type="STRING" id="742152.A0A2H3JW83"/>
    <dbReference type="OMA" id="QHNLGAP"/>
    <dbReference type="OrthoDB" id="10264870at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024738">
        <property type="entry name" value="Hfi1/Tada1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21277">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21277:SF5">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12767">
        <property type="entry name" value="SAGA-Tad1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="72"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="74"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="98"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
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    <sequence length="317" mass="35148" checksum="F1EE259B1694693D" modified="2018-01-31" version="1">MSLPSTTTTRHQLASALGPKASQYYAALREYLCARISRIEFDEQVKELLDSTHLVQLHNSLIVSLFDTSAHLAPPTPPPDVPKPPPRKRRRTLPYQGADSSDPSTLRSSRLKRWTVGLGRRERERIRQLETIAKPLELQPLPFRDEISAERGVQLLPERQEPAGSRLPLHLASVSRGFAVQHISDRINLISAQHNLGAPSKAVSSLMMLAFEAKLKQLIMHALSLTSTSHAIASIRTASKGSTNYPLSVSSFDTLFTISPAVLPNKSAAAMRMALGDSEAYEEEVPLKDRDVHDARWQLFALLSERSTVKEALRTLA</sequence>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
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                <person name="Benoit I."/>
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                <person name="Ferreira P."/>
                <person name="Findley K."/>
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                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
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                <person name="Kallen N."/>
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                <person name="Ling A."/>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Benoit I."/>
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                <person name="Ferreira P."/>
                <person name="Findley K."/>
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                <person name="Gaskell J."/>
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                <person name="Heitman J."/>
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</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the pre-66S ribosomal particle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
            <location evidence="1 6">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the eukaryotic ribosomal protein eS8 family. Ribosome biogenesis protein NSA2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB468146">
        <property type="protein sequence ID" value="PCH43679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="742152.A0A2H3JXP4"/>
    <dbReference type="OMA" id="TNTPEND"/>
    <dbReference type="OrthoDB" id="1847590at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030684">
        <property type="term" value="C:preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11381">
        <property type="entry name" value="NSA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.310:FF:000001">
        <property type="entry name" value="NSA2, ribosome biogenesis homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039411">
        <property type="entry name" value="NSA2_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022309">
        <property type="entry name" value="Ribosomal_Se8/biogenesis_NSA2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12642">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN NSA2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01201">
        <property type="entry name" value="Ribosomal_S8e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 6" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="67"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PCH43679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="271" mass="30648" checksum="FEFE469E213149FC" modified="2018-01-31" version="1">MPQSNEYIEEHIKRHGRRLDYYERKRKREAREAHRASATAQKAFGLKAKLLHAKRHAEKVQLKKTLKAHDERNVKQKDSSSVPDGALPTFLLDREGQKDAKALSTAIKEKRKDKAAKYAVPLPKVRGIAEDEMFKVMRTGKSKKKAWKRMVTKATFVGEGFTRKPVKMERFIRPMALRYKKANVTHPDLKATFQLQILGVKKNPQSPMYTQLGVLTKGTVIEVNVSELGMVTAGGKVVFGKYAQITNNPENDGCINAVLPCGTLYIRRGGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JXT0</accession>
    <name>A0A2H3JXT0_WOLCO</name>
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            <fullName evidence="1">Uncharacterized protein</fullName>
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            <taxon>Phaeolaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="PCH42658.1"/>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43668">
        <property type="entry name" value="ALLANTOINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43668:SF2">
        <property type="entry name" value="ALLANTOINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Metallo-dependent hydrolases"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="EMBL" id="PCH42658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
    </evidence>
    <sequence length="85" mass="9576" checksum="50EBF953096C9AF8" modified="2018-01-31" version="1">MLYGTFLALHPQQLEVDAIELIMALHRRYPTLWLRIVHLSTADALLLNRAAQQSGLSLVAEMCFHYLCLDATRMPNSYLTASSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JY08</accession>
    <name>A0A2H3JY08_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
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                <person name="Larrondo L.F."/>
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                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JY08"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH41057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="115" mass="13064" checksum="B635683FD20C7EC1" modified="2018-01-31" version="1" fragment="single">MPFLAPRYQHRFGISTHFRARSISQVLKNRVWSAANACAVCLFQRGGMTSGLHEDFSVMSVGHTEALYIAQQLCHCNLSLHRASDFRMVGVSEIHVAHSRLHPIRLHHTTTYLHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JYQ2</accession>
    <name>A0A2H3JYQ2_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_151914</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468124">
        <property type="protein sequence ID" value="PCH41874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JYQ2"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="232"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH41874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="448" mass="50116" checksum="04F60DCF8A146E5E" modified="2018-01-31" version="1">MSEQAPNHKDSPLLPEPSPPSVPPSPNPHNVSLEAPNPTPPSCESSPLSYMPNYPLLDIYDDDQEGSFSTTSVVIALGILARDAQHVYDLHHDTDLTHPLLTYSTATHRMLESIGTGATEFAARGLHNHIFMIRLRDKLIHLHHYIDDLIHKRDDEFSDMDDSESLPRISRPTTPDRPQSPVHIESTPPPPVIDPPTPIPPTQPSTVADQDTLTTTLQLILKRLDTLEQHVNNPTPQQTPTPSNTHIRKQPPTNPLTTPPKQPRTQTTSQHANCPPPDPTPTNEDYDMHLDDDHFPSLPQPTPPPFTTVTKCKKPQSYTQAVASNPNLRQNNQPPPAHPNRPTAEIPKHAIQDKLEWVICFSNRIPGNINKDAPDFALCQRINSGLHKAVQSRDANVAYIKWTLNNNVILSFDNNVTNDYIRTNIVPHIRQEFSLPDHVIISQNIPWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K1G9</accession>
    <name>A0A2H3K1G9_WOLCO</name>
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        <submittedName>
            <fullName evidence="6">Acid protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WOLCODRAFT_137787</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
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        <property type="protein sequence ID" value="PCH42247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="742152.A0A2H3K1G9"/>
    <dbReference type="OMA" id="SEGPAYM"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
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        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013709215" evidence="4">
        <location>
            <begin position="17"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="496"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="5">
        <location>
            <begin position="51"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="441"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="539"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="441"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PCH42247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="560" mass="59602" checksum="A9792B075E2B29D3" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K2W6</accession>
    <name>A0A2H3K2W6_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_144191</name>
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        <lineage>
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            <taxon>Agaricomycetes</taxon>
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            <taxon>Phaeolaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468135">
        <property type="protein sequence ID" value="PCH42747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K2W6"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH42747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="184" mass="21251" checksum="4CE578431EF75F2B" modified="2018-01-31" version="1">MKYPALEATLGNIVHRNPEIRFSDAWLKSEAKKLSSELSSKYGYKCKVSSTWLRMFKLRHGIKHGFCPVHYDGPLAIWKVSQALGLSTGLYVDNTVAEKGDRALQKLISYPDDLIPDESLRLAPEIQANDSKFAPERRRIRALKRFFADKGCPETNRTLTRMLVEELHLMGERLREEMWEDRVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K305</accession>
    <name>A0A2H3K305_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WOLCODRAFT_77152</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4 5">MD-104</strain>
        </source>
    </reference>
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Prot_kinase_dom"/>
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        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
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        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF298">
        <property type="entry name" value="MIXED LINEAGE KINASE DOMAIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="84"/>
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        </location>
    </feature>
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        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
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        </source>
    </evidence>
    <sequence length="402" mass="45747" checksum="693D94E75602F272" modified="2018-01-31" version="1" fragment="single">FKPSVQETLDSVRTLVSSREYREQAFQLERTEARSLIGLLDEVIVLVPPPDRLHISIFHALRTLCFLHGSLPKSCTIQTTELFKHHRPLRAVGGSAEVFSAHYKGEMVAIKVFRPPADRSESLRKEAIVWKHISHPNIVPFIGIDCSENSLGIVSTWMEHGTIMTFLKRDPYANRVKLLSDVAKGLQYLHLQGILHGDIKGTNILIDGQRRARLCDFGMAAVLYDPDTVHPMWTRSRPVGSIRWTAPEIVAPEYFGLDTTAVSSASPKSDVYSFAMTMWEVFTEKIPFQDHARDATVIWTAVNQQRRPLRDPASHWRGLSDNIWELIDRCWNHDPAQRPFIDEVLQSLNAELHRSQVRITSVRTTNGREAPPWSSRSISTIEIRGLTLLRVREINIHGYLSP</sequence>
</entry>
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    <accession>A0A2H3K560</accession>
    <name>A0A2H3K560_WOLCO</name>
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        <recommendedName>
            <fullName evidence="2">Conserved oligomeric Golgi complex subunit 5</fullName>
        </recommendedName>
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    <gene>
        <name evidence="7" type="ORF">WOLCODRAFT_164540</name>
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    <organism evidence="7 8">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
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        <lineage>
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            <taxon>Agaricomycetes</taxon>
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            <taxon>Phaeolaceae</taxon>
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    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="PCH43557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Cog5"/>
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    </dbReference>
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        <property type="entry name" value="COG5_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13228">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13228:SF3">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 5"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="7"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 5 helical" evidence="6">
        <location>
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            <end position="447"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00020974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF20649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PCH43557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="861" mass="95225" checksum="3A55AEAF58DE23FE" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K5I8</accession>
    <name>A0A2H3K5I8_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
            <ecNumber evidence="14">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">WOLCODRAFT_133171</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
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            <dbReference type="ChEBI" id="CHEBI:58211"/>
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</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K5Q2</accession>
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        <submittedName>
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        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
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            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">MD-104</strain>
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</entry>
<entry dataset="Swiss-Prot" created="2017-09-27" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
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        <name type="ORF">WOLCODRAFT_23632</name>
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    <reference key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>MD-104</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2017" name="Appl. Microbiol. Biotechnol." volume="101" first="5301" last="5311">
            <title>Characterisation of three fungal glucuronoyl esterases on glucuronic acid ester model compounds.</title>
            <authorList>
                <person name="Huttner S."/>
                <person name="Klaubauf S."/>
                <person name="de Vries R.P."/>
                <person name="Olsson L."/>
            </authorList>
            <dbReference type="PubMed" id="28429057"/>
            <dbReference type="DOI" id="10.1007/s00253-017-8266-9"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>BIOPHYSICOCHEMICAL PROPERTIES</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Glucuronoyl esterase which may play a significant role in biomass degradation, as it is considered to disconnect hemicellulose from lignin through the hydrolysis of the ester bond between 4-O-methyl-D-glucuronic acid residues of glucuronoxylans and aromatic alcohols of lignin. Can hydrolyze benzyl glucuronic acid (BnGlcA), allyl glucuronic acid (allylGlcA) and to a lower degree methyl glucuronic acid (MeGlcA) in vitro.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 4-O-methyl-alpha-D-glucuronosyl ester derivative + H2O = 4-O-methyl-alpha-D-glucuronate derivative + an alcohol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67452"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:171667"/>
            <dbReference type="ChEBI" id="CHEBI:171668"/>
            <dbReference type="EC" id="3.1.1.117"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:67453"/>
        </physiologicalReaction>
    </comment>
    <comment type="biophysicochemical properties">
        <kinetics>
            <KM evidence="5">3.4 mM for benzyl glucuronic acid</KM>
            <Vmax evidence="5">1.91 umol/min/mg enzyme for benzyl glucuronic acid</Vmax>
        </kinetics>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the carbohydrate esterase 15 (CE15) family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.117" evidence="5"/>
    <dbReference type="EMBL" id="KB468053">
        <property type="protein sequence ID" value="PCH39808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P0CU53"/>
    <dbReference type="SMR" id="P0CU53"/>
    <dbReference type="STRING" id="742152.P0CU53"/>
    <dbReference type="ESTHER" id="wolco-gce1">
        <property type="family name" value="Glucuronoyl_esterase"/>
    </dbReference>
    <dbReference type="OMA" id="EQPWLGD"/>
    <dbReference type="OrthoDB" id="3781271at2759"/>
    <dbReference type="BRENDA" id="3.1.1.117">
        <property type="organism ID" value="4987"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046274">
        <property type="term" value="P:lignin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054579">
        <property type="entry name" value="GCE-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22244">
        <property type="entry name" value="GCE_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0439">Lignin degradation</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0719">Serine esterase</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000441411" description="4-O-methyl-glucuronoyl methylesterase 1" evidence="3">
        <location>
            <begin position="20"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSYXG catalytic site motif" evidence="1">
        <location>
            <begin position="217"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="219"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="353"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="4">
        <location>
            <position position="287"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="4">
        <location>
            <position position="350"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="4">
        <location>
            <position position="390"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="4">
        <location>
            <position position="395"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="4">
        <location>
            <position position="401"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="31"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="218"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="250"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="G2QJR6"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P0CT87"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3"/>
    <evidence type="ECO:0000255" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="28429057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <evidence type="ECO:0000305" key="7">
        <source>
            <dbReference type="PubMed" id="28429057"/>
        </source>
    </evidence>
    <sequence length="408" mass="44123" checksum="91025084BE34D139" modified="2017-09-27" version="1" precursor="true">MASSSRFAALLLLALPALALPPSQVVPRAACATPSTVPGYNNDRLPDPFLFDDGTAVTSSADWDCRRSQIAAVVQGYEAGYLPPQPPIVSATFSSSDGTGTLTVTAGLSSDNTISFSEPITYPSGTAPAAGWPLVIAYDVLSIPVPDGIAVMVYNNDDIAQENDLSSRGVGLFYDLYGTDATASAMTAWVWGVSRIIDALETTPAANINTAKIAVTGCSRDGKGALMAGAFEPRVALTIPQESGSGGDTCWRLSKYEQDSGDVVQQATEIVTENVWFSTNFDNYVNNLSVLPYDHHELAAMVAPRPLLSYENTEYEWLSPLSAYGCMSAAHTVYEALGIPDYHGFVQVGNHSHCYFPDTLDDSLYAFFDRFLLDEDDVSTDYFTTNYQFNGTVWNASYWINWTTPQLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IT92</accession>
    <name>A0A2H3IT92_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">SET domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WOLCODRAFT_21838</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH33200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3IT92"/>
    <dbReference type="STRING" id="742152.A0A2H3IT92"/>
    <dbReference type="OMA" id="HMSGSPK"/>
    <dbReference type="OrthoDB" id="308383at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050973">
        <property type="entry name" value="H3K9_Histone-Lys_N-MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007728">
        <property type="entry name" value="Pre-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46223:SF3">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SET-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46223">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SUV39H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05033">
        <property type="entry name" value="Pre-SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00468">
        <property type="entry name" value="PreSET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50867">
        <property type="entry name" value="PRE_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Pre-SET" evidence="10">
        <location>
            <begin position="136"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="9">
        <location>
            <begin position="210"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="11">
        <location>
            <begin position="358"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PCH33200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="375" mass="41670" checksum="49A93624CA7237C1" modified="2018-01-31" version="1">MLPSNALQNARHRRPQRVISSSDSDSRLSPPVRTRTTSGDVARTERPIRPLPRRSRPESWHTSSTLSGSSITRRAKLQSLWRHEASRVGALASVTFVNDVNSDEVPPGLDNFKYCERHYVRAQGIPGTADMSGALVACECDTSCDDAEQCGCQRPSELVDDHNAREFAYTDQGLFRFNVPQGVAVIECNRNCLCDVYTCPNRVAQRPRNVPIEIFRTQDCGWGARAAVSLVKGKVLGLYTGELITREDAAKRTGDAKSYIFDLDMHEMEGEEADQPKYSVDASSCGNWTRFVNHSCEPNVKVYPVVWDTVPEQCQPYLAFVTTQDIPERTELTIDYEPQASAVDRRDKGKGKSRIPPGARPCVCGAGGCRGWVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IVG0</accession>
    <name>A0A2H3IVG0_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_135125</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH33415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3IVG0"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH33415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="118" mass="13472" checksum="29F1F508F0F7B53A" modified="2018-01-31" version="1">MGNGYVTVRMRNPRSEVRDCCPRQPMPRSSGLAAGSRSRCNPNLDFQVSLSIIYSHCPGHVHPDNAEIPLEFQCYARSAHKISTFRWHRTTDETRQPLCRRTRPATPCWLQCSRTVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IVK9</accession>
    <name>A0A2H3IVK9_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_147560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH33465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3IVK9"/>
    <dbReference type="STRING" id="742152.A0A2H3IVK9"/>
    <dbReference type="OrthoDB" id="2799478at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH33465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="384" mass="42278" checksum="A1CA3608BEBB6F64" modified="2018-01-31" version="1">MAGFEMGSQRTPRAATGLGQHQAIHRPSLNPVGPHILPTRRTGKPAGPPLHYAHQWHPIEDWVSCAERLKSNPTVYAAFWQVVALVRWTLPNALGIVATWAWSAATAQPTPLPSHSAMRTPDQPNLGCVPHPPVRAVGLLPAHTAHEDDWGDALGNLPGVPSPPGAPLHPVESRTEPGPSVAPPRPSAPAHPPSPICQPSTTPDMGAQTAPTAPPQHARPRKRRWNTRASIQLATLNMRDRGTTHQPLHDAHQSTLDKWNMIYHLVREQRIGILALQETHTLTPNFLDNLDHMYGRRLRVIHSPDPTNSAVHRVAFILNQEITNVCDIMSRTLVPGRALLLSIKWHGEDTLHILNVYAPNSPTSNQAFWNDLQEFWSGEAPDLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IWI0</accession>
    <name>A0A2H3IWI0_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">diacylglycerol cholinephosphotransferase</fullName>
            <ecNumber evidence="9">2.7.8.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WOLCODRAFT_22625</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>CDP-N,N-dimethylethanolamine + a 1,2-diacyl-sn-glycerol = a 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33775"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:64572"/>
            <dbReference type="ChEBI" id="CHEBI:65117"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:33776"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Phospholipid metabolism; phosphatidylcholine biosynthesis; phosphatidylcholine from phosphocholine: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.2" evidence="9"/>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH34342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3IWI0"/>
    <dbReference type="STRING" id="742152.A0A2H3IWI0"/>
    <dbReference type="OMA" id="PCVLTCL"/>
    <dbReference type="OrthoDB" id="196717at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004142">
        <property type="term" value="F:diacylglycerol cholinephosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1760:FF:000012">
        <property type="entry name" value="sn-1,2-diacylglycerol cholinephosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014472">
        <property type="entry name" value="CHOPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414:SF37">
        <property type="entry name" value="BB IN A BOXCAR, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414">
        <property type="entry name" value="ETHANOLAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015665">
        <property type="entry name" value="CHOPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="262"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="290"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="360"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PCH34342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="419" mass="47168" checksum="17A7A408E9BB6344" modified="2018-01-31" version="1">MGYIPQHALENLRKYSYKGIDKSLTSIYILQPFWTWFVSLWPTWVAPNTITLSGLCMVLLNFATLLYYDPTYLTDKEGAGPPQWIYLTWALGLFLYQTFDAIDGKQARRTGMAGPLGEMFDHGCDALNTTLEAVLAARALNLGRSWWTVASQIATLANFYLSTWEEYHTGILFLGWFSGPVEGILIIVGIYLISGVFGPSFWDQRLLDFTGLINVSAVANRVPNIPLNETFMVFGAFGLGFNILVSYLNVFNSRMSGNKNPFVPLLFLLPFPISAAMEVFWLSAPSIHESAILHSALFVPFMCAWGLQFAHQVSRMILAHVTKQPFPWWDSMWVWSIVGAVDANLPLLLNRPPLIQSSRYNIAVFVYVTLAVSFLSYARFCMLVIKDITNYLGIACFTVRKKDKSGEWVEAAVVDGKKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IXQ6</accession>
    <name>A0A2H3IXQ6_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA-processing protein 42</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WOLCODRAFT_139562</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467832">
        <property type="protein sequence ID" value="PCH34762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3IXQ6"/>
    <dbReference type="STRING" id="742152.A0A2H3IXQ6"/>
    <dbReference type="OMA" id="RWPVCVT"/>
    <dbReference type="OrthoDB" id="272245at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034473">
        <property type="term" value="P:U1 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034476">
        <property type="term" value="P:U5 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050590">
        <property type="entry name" value="Exosome_comp_Rrp42_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097:SF8">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RIBOSOMAL RNA PROCESSING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0271">Exosome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="7">
        <location>
            <begin position="34"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PCH34762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="341" mass="36929" checksum="7DBF7E6CFA074F7B" modified="2018-01-31" version="1">MASVSLSKAEKSFIQTSLQATPPLRADGRALLDYRTVLLETGVASQANGSAKLNVGKAPLEGGGGTEVLAATKLEVEDVENGDGLDGGRIVCAVTCSPSAYPHLSSNALDEVQYDLTMILHQTISHQTLHPKNLGILPKKKSWLLNLDVVVFADAGNVLDAIFMAARAALWDTKVPRTRAIQYQAKKAGSGTGSGDMDVDSGNEPGHGLSGFDTRDMARTAADFELPDYWDEGEVLDGRDRWPVCVTLNVLPSHHYLDATTPEEASTPLKLHLAFSFPTDQPCHLQALRLLGPGELQLPQLKTLIADGEKYAKELFTALESKLRDEDLRRNVKARDKFASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IXS5</accession>
    <name>A0A2H3IXS5_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_155190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467832">
        <property type="protein sequence ID" value="PCH34531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3IXS5"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH34531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="224" mass="25087" checksum="74F08C044C9C4CA0" modified="2018-01-31" version="1">MPRNGQLHPSRARSFAPAGGATDVLAHSHRCPSVRTTPQLHIHLASSAAQLTIQQLLRAIPSSPPTRRADAPPHAPPLVPSRTTPVQRFSPIAHHRRCFRAVHARMRKQQTARPDALAYNHYSDGLHLYFFIAHYTHRSRPPLRPLLDVYPQVSDKRSPPVLSVFSARLPPPGFLSCSVSRRLQWHRTCTPPSYLRARDPHPLDTLELVSGSSALERTPLSLNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IYJ6</accession>
    <name>A0A2H3IYJ6_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">General stress protein 39</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WOLCODRAFT_91384</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467843">
        <property type="protein sequence ID" value="PCH35052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3IYJ6"/>
    <dbReference type="STRING" id="742152.A0A2H3IYJ6"/>
    <dbReference type="OMA" id="FSMFHMT"/>
    <dbReference type="OrthoDB" id="1393670at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107:SF16">
        <property type="entry name" value="NADPH-DEPENDENT ALDEHYDE REDUCTASE 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107">
        <property type="entry name" value="NADPH-DEPENDENT ALDEHYDE REDUCTASE-LIKE PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PCH35052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="305" mass="33322" checksum="A7FDB4713A8BE19D" modified="2018-01-31" version="1">MSAHEGTTLKQRIPAQEREMPGLQKHMEPEPFDTRLEAGSGPKPYTGVGKLGGKKSSHHQRRISSSSRRRANEPIAVHSSGIGRAVVIFFAREGADVTIVHLPNEQKDAEDTARAIQNEGWRALSIAFDLEDFHNANKVGAAHVQQFGRIDILELEGDFAQIDLHEVESTFRSNILQMFAVTKFALPHMAKGSSIINTTSVTTFRGSSSMVDYVSTRSAIVGFARALARQLEPKGIRVNAVAPELVHTPLQPASRPAEQTEGFGEKTSIGRVGQPSEIAPSYVFLASAEAELYYGQILHPYPLGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IYT6</accession>
    <name>A0A2H3IYT6_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_165886</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467832">
        <property type="protein sequence ID" value="PCH34891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3IYT6"/>
    <dbReference type="OMA" id="GMILECL"/>
    <dbReference type="OrthoDB" id="2758792at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH34891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="586" mass="66105" checksum="FD8C49FD8964C11A" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J0I1</accession>
    <name>A0A2H3J0I1_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nuclear protein localization protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">WOLCODRAFT_111569</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Involved in the import of nuclear-targeted proteins into the nucleus and the export of poly(A) RNA out of the nucleus. Has a role in the endoplasmic reticulum-associated degradation (ERAD) pathway.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Perinuclear region</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the NPL4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH33293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J0I1"/>
    <dbReference type="STRING" id="742152.A0A2H3J0I1"/>
    <dbReference type="OMA" id="KWSRTGR"/>
    <dbReference type="OrthoDB" id="10251089at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08061">
        <property type="entry name" value="MPN_NPL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000243">
        <property type="entry name" value="Nuclear protein localization protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016563">
        <property type="entry name" value="Npl4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007717">
        <property type="entry name" value="NPL4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024682">
        <property type="entry name" value="Npl4_Ub-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007716">
        <property type="entry name" value="NPL4_Zn-bd_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12710">
        <property type="entry name" value="NUCLEAR PROTEIN LOCALIZATION 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12710:SF0">
        <property type="entry name" value="NUCLEAR PROTEIN LOCALIZATION PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05021">
        <property type="entry name" value="NPL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11543">
        <property type="entry name" value="UN_NPL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05020">
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        </source>
    </evidence>
    <sequence length="439" mass="49416" checksum="0409749A8F8966F8" modified="2018-01-31" version="1">MLSEGASAPTMLLSPRPLARTAGRIQLLPLLPYRPEPKPLPSEVWTKILADVFAHYDLDASRPRAECDALKKGLLLICKELKSVALPLFYARVCIASLHSLERFAAHIFSSDQKWDSIRRIPYSTPGRWVNTLDLRDLDIHTLPETFRVDTLLTYLFPVLPFLDRFMLSPTIVLSRRATLSLISRSEIIHLHTLKGLKLESYPSIGDDCFVDLLRACVNLEELTIVGSGVEVSEGLEQDHSIPASAFKPLVLRYLHKLVLLSMPCSPAMYALLHAQLPSLRHLTITPYDGDIIPTSLVPQFIRAHGQTLQSLHLYTTKTWPATLHPSPSTLLQDCPNLSHLSLENPLPILMLSSADPPHPLHILSIPRPYPEFLAVLDALLPKLPALRILRARDVRWIRPGMSLRAQQAGVQGEMVEWRRRLSRRGVQVVDSEWKRGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J2V7</accession>
    <name>A0A2H3J2V7_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CHY-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WOLCODRAFT_140512</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467887">
        <property type="protein sequence ID" value="PCH36590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J2V7"/>
    <dbReference type="STRING" id="742152.A0A2H3J2V7"/>
    <dbReference type="OMA" id="HQEQESH"/>
    <dbReference type="OrthoDB" id="411372at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045041">
        <property type="term" value="P:protein import into mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052604">
        <property type="entry name" value="Mito_Tim_assembly_helper"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008913">
        <property type="entry name" value="Znf_CHY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037274">
        <property type="entry name" value="Znf_CHY_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28082:SF2">
        <property type="entry name" value="CHY-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28082">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05495">
        <property type="entry name" value="zf-CHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161219">
        <property type="entry name" value="CHY zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51266">
        <property type="entry name" value="ZF_CHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CHY-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PCH36590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="121" mass="14113" checksum="85E6D93ACA448512" modified="2018-01-31" version="1">MCKHILNAQVAIRAPCCKQWFDCAECHAETQDHRLRKTTEMIFMCKKCKKAFRKDMSNYEESDEYCPHCDNHYVIEAKTPQPVLGVEGDDPRIDARMLKDERVQQVPSRSFVAQDFSDRIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J3F9</accession>
    <name>A0A2H3J3F9_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_20581</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467876">
        <property type="protein sequence ID" value="PCH36501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J3F9"/>
    <dbReference type="STRING" id="742152.A0A2H3J3F9"/>
    <dbReference type="OrthoDB" id="10039566at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH36501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="416" mass="45939" checksum="CF655EADF90CD720" modified="2018-01-31" version="1">MEKALFEGYLTGRMCLTQSNGILSSPPQIATSSRIPNFIISYRPKHALGHRDQPLGRPTTAGGTSTQTRLIKMSTAGVDAGALALTLADGKDRTPVMTVLILNLQLGAQADSHYGSSPSLSSFYVMVKLLLRLKLKASLKPNRKSSMPDCVRKILQRLQSFRDKVSLSGFQIIGSIKQSNGDGYMRAVVNAEVENSTKVSCVANIAVVVYYGDTKIGSVELENFQIRPEIPTRQEVEWRSRPLNPVNSDVQRLFANQVITKMESPIKLRIENISAKICGRLFNLPRYEIQTQIRGLGIQLVRHVNVHVLLMSVMFRRNVSFELDFASIHQIDAAPENPVDTRLQIHSIDLNVSVRGVHIATVKHNFGNTFFIDPKDRNKTPEIADAYLVGGLLKTLQMGTETSACLDVVVKAASVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J3Y7</accession>
    <name>A0A2H3J3Y7_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ClpP/crotonase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WOLCODRAFT_140663</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467898">
        <property type="protein sequence ID" value="PCH36962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J3Y7"/>
    <dbReference type="STRING" id="742152.A0A2H3J3Y7"/>
    <dbReference type="OMA" id="YEQAHAW"/>
    <dbReference type="OrthoDB" id="410701at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000009">
        <property type="entry name" value="Carnitinyl-CoA dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.12.10:FF:000001">
        <property type="entry name" value="Probable enoyl-CoA hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF171">
        <property type="entry name" value="SD19268P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PCH36962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="245" mass="26165" checksum="8B9C46B9BDB5AFBC" modified="2018-01-31" version="1">MLNRPQAKNAISLQLLREFRECLNSVQFDNSVRVLIVRSSTPGSFCAGADLIERRSMSKPQVDKFLLDLRGALATLENLPVPTIAAIDGPALGGGLEMSLACDLRVAGHSVTKIGLPETRLGIIPGAGGTQRLTRLLGLSRAKNLIFTARSLSASEALDSGLVDYVSTADSSAVDKALELAAEIALNAPLALRAAKQAISRAPELSLESGLDFERAAYEPLLKTNDRIEALEAFKEKRAPVFKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J589</accession>
    <name>A0A2H3J589_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_112774</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH33909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J589"/>
    <dbReference type="STRING" id="742152.A0A2H3J589"/>
    <dbReference type="OMA" id="GWINEAR"/>
    <dbReference type="OrthoDB" id="5592486at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11440">
        <property type="entry name" value="LECITHIN-CHOLESTEROL ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="388"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="398"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH33909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="452" mass="48837" checksum="AF83D600313D11AC" modified="2018-01-31" version="1">MFLSPTPTPVAIPHSPAPAHISDEPRAGARSSLDTLRTIHARGRSVHTSAPAPAPLRLPALSGSLPGSLRSWFGDGGSAQGSRESVHALLGDEDKQPTRQAEREHIKKKYCAPKNPVVFCHGLLGFDTVTLGPAIAPLQVTHWRGIKEAFEENGCEVLMTRVPATSSPVDRAQVLLEKISAVYAGRSVHLIGHSMGGLDCRYLTTHLLRGAPGRPAPFRVLSVTTISTPHRGSAFADHFLATVGRARMPRVLALLDLLPNGGGDGAAFEFLTVENMRRFNARTPDVEGVKYFSWGAVYEPGLIDTWKWPHSVIMEKEGPNDGLVSRASAEWGTYLGTLEGVNHLELIGWVNSARYKWAEIMGRELKFRPVTFYLGIADHLARVVEGQGGGGAGGAGGREGEGREARREREEREEIGREGERAEMAESLGKGAEADVPAREEGAANGDERGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J599</accession>
    <name>A0A2H3J599_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_84518</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467931">
        <property type="protein sequence ID" value="PCH37410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J599"/>
    <dbReference type="STRING" id="742152.A0A2H3J599"/>
    <dbReference type="OrthoDB" id="10039566at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH37410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="490" mass="55733" checksum="2D1457206FDC50DD" modified="2018-01-31" version="1">MADTQNIGRPFKSGHYTITNVAYANRIKLSNADDGEQAVGRIPFDEELINPLELWQISRSSEGSLDRCTIKNIHLNRFLSTKPTASHTDTVFGDAQEYCWILYADDSSVDVYRICTPSTLCLTLKDGCNDTPVSSPDQDTMTVQLEWNDLPPRHVLRLFNPVSVIFHGEIIADAHVDEEFHTDTKILNAALHARDTNAFRKFIHSVLCVDEIQISFEARGFHYFHASQDRSEIGNYEYRIPWKKDLIFKGLQSFRDKVLLKRLTITASGPSEVEPYLDIELLTSLINNTNLTCIADYSVSLYYGASKARTISPKSPNQQIVKGRFQPLTPPVDEIRRFLGAFLTSNRQQLVKLRVEGINITICGRLFNLPGFEINSYLQGLGAQIVHHVDVYLKLFPYFLQRRISFRFFLKNPIDTDVMLKGFSVDAYVKGVCMAHVKHVFQTPLLLTKEGVWSPKIGEAFLDAGYFRSWQLVFDHAAVLDLKIRSIDIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J5B2</accession>
    <name>A0A2H3J5B2_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C-CAP/cofactor C-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WOLCODRAFT_134530</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD-104</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="5">Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TBCC family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467931">
        <property type="protein sequence ID" value="PCH37432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J5B2"/>
    <dbReference type="STRING" id="742152.A0A2H3J5B2"/>
    <dbReference type="OMA" id="YFQHEIT"/>
    <dbReference type="OrthoDB" id="194775at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007023">
        <property type="term" value="P:post-chaperonin tubulin folding pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1250">
        <property type="entry name" value="Tubulin Binding Cofactor C, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017901">
        <property type="entry name" value="C-CAP_CF_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016098">
        <property type="entry name" value="CAP/MinC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027684">
        <property type="entry name" value="TBCC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031925">
        <property type="entry name" value="TBCC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038397">
        <property type="entry name" value="TBCC_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012945">
        <property type="entry name" value="Tubulin-bd_cofactor_C_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15139">
        <property type="entry name" value="TUBULIN FOLDING COFACTOR C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15139:SF0">
        <property type="entry name" value="TUBULIN-SPECIFIC CHAPERONE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07986">
        <property type="entry name" value="TBCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16752">
        <property type="entry name" value="TBCC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51329">
        <property type="entry name" value="C_CAP_COFACTOR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-CAP/cofactor C-like" evidence="7">
        <location>
            <begin position="113"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="95"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00026055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PCH37432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="326" mass="35437" checksum="5FC5152A21865787" modified="2018-01-31" version="1">MAETSQSLAREFYIHFQSKHAELVARIDSHSSSAATSDALDQLSADIVTLRKELTDATGFLPSYDQRQCELKVRDLEAQVEKLRASAAPKAKFAFKRKPKTAPTVPTAASSAPTSSHSSSLGTTQQAAPGLVISGRSQEFLGLSSLSLGQNQVSSDLTLSDIERCIVCLLPSDRSDATTSTSPSTLKITSLHVRNVRNSVLILPKIEGSALLHDVSLSVIVLGCHQYRMHTSSKVDVYISASSNPIIEHCSGIRFAGYPRSLHQRAGAEENDQTNNYLAVQDFSHIRPTPSPNWSLMQQEEMVADSDWPVDHVELAFLFAVAFKAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J5L5</accession>
    <name>A0A2H3J5L5_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">UPF0220-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WOLCODRAFT_133700</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0220 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467843">
        <property type="protein sequence ID" value="PCH35053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J5L5"/>
    <dbReference type="STRING" id="742152.A0A2H3J5L5"/>
    <dbReference type="OMA" id="VHITFVD"/>
    <dbReference type="OrthoDB" id="268928at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007919">
        <property type="entry name" value="UPF0220"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13180">
        <property type="entry name" value="SMALL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05255">
        <property type="entry name" value="UPF0220"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PCH35053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="184" mass="20205" checksum="B653B45B527F006B" modified="2018-01-31" version="1">MSLPRANYDPRRVCLNPFPALNLGKHRRTIGIYLAGGLFALANWTFLDAAVLSAHAHSPYGEPDIPPPVHVTFVDWVPGICSLLGMLIINLIDKDRVRGEEGFGDGGAVWRARLILFIGFALMAGGLAGSVTILVLKYVLNDYPEQYTYYGYANVSQNVALMLSAIVLWISQSVGSEYEYNLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J5Q6</accession>
    <name>A0A2H3J5Q6_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Histone H2B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">WOLCODRAFT_27632</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the histone H2B family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467843">
        <property type="protein sequence ID" value="PCH35093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J5Q6"/>
    <dbReference type="STRING" id="742152.A0A2H3J5Q6"/>
    <dbReference type="OMA" id="FCPFAIR"/>
    <dbReference type="OrthoDB" id="10254238at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22910">
        <property type="entry name" value="HFD_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000014">
        <property type="entry name" value="Histone H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000558">
        <property type="entry name" value="Histone_H2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055333">
        <property type="entry name" value="HISTONE_H2B_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23428">
        <property type="entry name" value="HISTONE H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00621">
        <property type="entry name" value="HISTONEH2B"/>
    </dbReference>
    <dbReference type="SMART" id="SM00427">
        <property type="entry name" value="H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00357">
        <property type="entry name" value="HISTONE_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="10 11" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="13">
        <location>
            <begin position="41"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PCH35093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="147" mass="15563" checksum="0B68A52E80AF822E" modified="2018-01-31" version="1">MAPKPASTAGKAPASTASKAPAKSTEGTKSAKKTSKPAAAAGDDTKKKRRKSRKETYSSYIYKVLKQVHPDTGISNKAMAILNSFVNDIFERIASEASKLASYSKKSTISSREIQTAVRLILPGELAKHAISEGTKSVTKFSSAGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J6C8</accession>
    <name>A0A2H3J6C8_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acetyl-CoA synthetase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WOLCODRAFT_135856</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH37800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J6C8"/>
    <dbReference type="STRING" id="742152.A0A2H3J6C8"/>
    <dbReference type="OMA" id="CGAPIVY"/>
    <dbReference type="OrthoDB" id="10253115at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43859">
        <property type="entry name" value="ACYL-ACTIVATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43859:SF4">
        <property type="entry name" value="BUTANOATE--COA LIGASE AAE1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="5">
        <location>
            <begin position="47"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="6">
        <location>
            <begin position="480"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PCH37800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="575" mass="63433" checksum="72222CCD037AC0D5" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J6H3</accession>
    <name>A0A2H3J6H3_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Mov34-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WOLCODRAFT_130498</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M67A family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH37816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J6H3"/>
    <dbReference type="STRING" id="742152.A0A2H3J6H3"/>
    <dbReference type="OMA" id="HAMSIKT"/>
    <dbReference type="OrthoDB" id="10256771at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08062">
        <property type="entry name" value="MPN_RPN7_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000004">
        <property type="entry name" value="26S proteasome regulatory subunit rpn-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024969">
        <property type="entry name" value="EIF3F/CSN6-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033858">
        <property type="entry name" value="MPN_RPN7_8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540:SF7">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13012">
        <property type="entry name" value="MitMem_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPN" evidence="5">
        <location>
            <begin position="17"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="295"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="302"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PCH37816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="336" mass="37486" checksum="D5893BA49884F460" modified="2018-01-31" version="1">MVATTSEQLAALSGTTVVVHPLVLLSVADHHARTVKSRSSNKRVIGILLGQDNGKTVNVANSFGIPFEEDEKDSKIWFLDHNYIEGMWEMFKKVNARERMIGWYHTGPKLRASDQEINDLLKRFIARPIMVIVDVRPQTVGIPTDAYFAVEEIKDDGTETRKTFLHVPSAIEAEEAEEIGVEHLLRDIKDSTTTTLATRVSEQLASLRGLQSRLADIQKYLVDVAAGNMPVNHQIVYHLQDALNLLPNLSDSETTQSFTASTNDQLLVVYLSSLLRAVIALHALVDNKATIGRAELEESQGIDEKDKKDKSEKADEKEKKKDEKVEEKGKDSAKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J6V7</accession>
    <name>A0A2H3J6V7_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">IRG-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WOLCODRAFT_148611</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH37661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J6V7"/>
    <dbReference type="STRING" id="742152.A0A2H3J6V7"/>
    <dbReference type="OMA" id="TITRYRD"/>
    <dbReference type="OrthoDB" id="422720at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030385">
        <property type="entry name" value="G_IRG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007743">
        <property type="entry name" value="Immunity-related_GTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051515">
        <property type="entry name" value="IRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32341">
        <property type="entry name" value="INTERFERON-INDUCIBLE GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32341:SF10">
        <property type="entry name" value="INTERFERON-INDUCIBLE GTPASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05049">
        <property type="entry name" value="IIGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51716">
        <property type="entry name" value="G_IRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IRG-type G" evidence="6">
        <location>
            <begin position="179"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="29"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="114"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="39"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="114"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="135"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PCH37661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="375" mass="42891" checksum="C9E26563E2713879" modified="2018-01-31" version="1">MSGPIADRDRIIGQEREWRADAERRREWAEGQMRNAQEQQRHAEGAQREAQKRVGQAEEELAKLRAEIKRDIEERKKREEEERGRVEEEKRKVDAALSQVEELRMQVEARLRVEEDKRKKAEDAQNAAELTAARAQKEKETLEQEKTEEQRRTPAIKPIIIPTDTEVETTKRKLGYQEGTFHFAIAGISGSGKSSLINAFRGMHNRDSGAAPTGVTGTTRVITRYTDPAPANPFAWYDIFDCIIVLIDTRFTATDVAILRNCARFGMPAYIVRSKSNQHIRNIMEDIGYDSNDDDDATTRRALAEAARERYIADTRQTVTENLEEAGLLPQRVYVVSKDTMLRVVRQEPARDLLDEVQLRDALLTTARMERLQGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J6X3</accession>
    <name>A0A2H3J6X3_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WOLCODRAFT_129747</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the C/M/P thioester hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH33398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J6X3"/>
    <dbReference type="STRING" id="742152.A0A2H3J6X3"/>
    <dbReference type="OMA" id="VHGRMYT"/>
    <dbReference type="OrthoDB" id="68328at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21077">
        <property type="entry name" value="DBD_Rad14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03444">
        <property type="entry name" value="Thioesterase_II_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03445">
        <property type="entry name" value="Thioesterase_II_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.210">
        <property type="entry name" value="Acyl-CoA thioesterase, double hotdog domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.530.10">
        <property type="entry name" value="XPA C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049450">
        <property type="entry name" value="ACOT8-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042171">
        <property type="entry name" value="Acyl-CoA_hotdog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003703">
        <property type="entry name" value="Acyl_CoA_thio"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049449">
        <property type="entry name" value="TesB_ACOT8-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000465">
        <property type="entry name" value="XPA/RAD14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022656">
        <property type="entry name" value="XPA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022658">
        <property type="entry name" value="XPA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037129">
        <property type="entry name" value="XPA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00598">
        <property type="entry name" value="rad14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066">
        <property type="entry name" value="ACYL-COA THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066:SF34">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13622">
        <property type="entry name" value="4HBT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20789">
        <property type="entry name" value="4HBT_3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05181">
        <property type="entry name" value="XPA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="Putative DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00753">
        <property type="entry name" value="XPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="XPA C-terminal" evidence="7">
        <location>
            <begin position="180"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA thioesterase-like N-terminal HotDog" evidence="8">
        <location>
            <begin position="341"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA thioesterase-like C-terminal" evidence="9">
        <location>
            <begin position="485"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF20789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PCH33398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="622" mass="71265" checksum="4BDC0C357F5ED2F8" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J745</accession>
    <name>A0A2H3J745_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Inosine monophosphate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WOLCODRAFT_95762</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH37751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J745"/>
    <dbReference type="STRING" id="742152.A0A2H3J745"/>
    <dbReference type="OMA" id="FLFTPEC"/>
    <dbReference type="OrthoDB" id="2349068at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PCH37751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="338" mass="36419" checksum="2CC7F9A06D529873" modified="2018-01-31" version="1">MPVPIRTKFTSLFNVSSPIVSAPMAYATSPALVAAVINGGGVGFLAAGLEPAVKLGEAIDQARAAISDDKKHLVSMGFISWVLDKFDSENDQRLQTVLDKEVYAVWFAYGTDLGKHIARVRAYDATRNHKTLVCMTANTTEEAVRAANEWKPDLIVMQGSEAGGRGSTYSPPIQELLQAAVHAIPEDGPIVLAAGGVVRGEQVAKLLTLGASGVVIGTRFLFTNECAWTDEMKSVIIEAGAESTERSPAYDVIFPPGVWPDGIQARCVKNEVLRDFEYGLSEEERKQNIQNGRKDHLLVYAGIGVAEMSEVQSASDVFRSLHEETVTTLSDGGSHLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J7F9</accession>
    <name>A0A2H3J7F9_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Succinyl-CoA:3-ketoacid-coenzyme A transferase</fullName>
            <ecNumber evidence="3">2.8.3.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WOLCODRAFT_23120</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 3-oxo acid + succinyl-CoA = a 3-oxoacyl-CoA + succinate</text>
            <dbReference type="Rhea" id="RHEA:24564"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:35973"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="2.8.3.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Ketone metabolism; succinyl-CoA degradation; acetoacetyl-CoA from succinyl-CoA: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the 3-oxoacid CoA-transferase family.</text>
    </comment>
    <dbReference type="EC" id="2.8.3.5" evidence="3"/>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH38156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J7F9"/>
    <dbReference type="STRING" id="742152.A0A2H3J7F9"/>
    <dbReference type="OMA" id="DWRHRIA"/>
    <dbReference type="OrthoDB" id="1933379at2759"/>
    <dbReference type="UniPathway" id="UPA00929">
        <property type="reaction ID" value="UER00894"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008260">
        <property type="term" value="F:succinyl-CoA:3-oxo-acid CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046952">
        <property type="term" value="P:ketone body catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1080.10">
        <property type="entry name" value="Glutaconate Coenzyme A-transferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012792">
        <property type="entry name" value="3-oxoacid_CoA-transf_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012791">
        <property type="entry name" value="3-oxoacid_CoA-transf_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014388">
        <property type="entry name" value="3-oxoacid_CoA-transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004165">
        <property type="entry name" value="CoA_trans_fam_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02429">
        <property type="entry name" value="pcaI_scoA_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02428">
        <property type="entry name" value="pcaJ_scoB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13707:SF60">
        <property type="entry name" value="ACETATE COA-TRANSFERASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13707">
        <property type="entry name" value="KETOACID-COENZYME A TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01144">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000858">
        <property type="entry name" value="SCOT-t"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00882">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 5" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="5-glutamyl coenzyme A thioester intermediate" evidence="4">
        <location>
            <position position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000858-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PCH38156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="527" mass="56270" checksum="0BD41CBEF88024B9" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J861</accession>
    <name>A0A2H3J861_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetyl-CoA synthetase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_112607</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH33828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J861"/>
    <dbReference type="STRING" id="742152.A0A2H3J861"/>
    <dbReference type="OMA" id="MGSLCHM"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
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        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ACYL-COA SYNTHETASE FAMILY MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23562">
        <property type="entry name" value="AMP-binding_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="2">
        <location>
            <begin position="12"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH33828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="545" mass="60930" checksum="8B1942997B645111" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J8Q2</accession>
    <name>A0A2H3J8Q2_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_134140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467865">
        <property type="protein sequence ID" value="PCH36173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J8Q2"/>
    <dbReference type="OMA" id="AVQLHNE"/>
    <dbReference type="OrthoDB" id="9876299at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05325">
        <property type="entry name" value="carb_red_sniffer_like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052184">
        <property type="entry name" value="SDR_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458:SF3">
        <property type="entry name" value="CHAIN DEHYDROGENASE (ATSC), PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE SDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH36173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="250" mass="27072" checksum="24CE05EC788544CD" modified="2018-01-31" version="1">MASYLITGASRGIGLAFVEELLNNPENFVIASARNPHGSTRLQALATQYPRDRLVLMVLDYADTASVDRAAEQANELLPDGLDYLISNAGVHMQAFATLDTIDLNIFEEELRINTIAPVHVLRTFLKLIREGSAKKVVFITSNLGSMAAAPILSTVGFTYSASKAALNVLARKWGAILSDEGIAVVVIHPGWVDTEMGTKIDENWVAENFPGASKISARECATGCIKVMTEAGPEKDIRFYASDGSELPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J8T3</accession>
    <name>A0A2H3J8T3_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Carboxymuconolactone decarboxylase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_136369</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH38620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J8T3"/>
    <dbReference type="STRING" id="742152.A0A2H3J8T3"/>
    <dbReference type="OrthoDB" id="5537330at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052999">
        <property type="entry name" value="PTS1_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28180">
        <property type="entry name" value="CONSERVED MITOCHONDRIAL PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28180:SF2">
        <property type="entry name" value="PEROXISOMAL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxymuconolactone decarboxylase-like" evidence="1">
        <location>
            <begin position="155"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH38620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="240" mass="25856" checksum="A186EACC8E73DCB7" modified="2018-01-31" version="1">MAELATPEFLDELKAIYLAEAGADVKGVPPWYMVATAAFSSSGVAAAVPIVFKYALDDLKKTYDGEELLMHSRTLASKLREGLLASCVLCGLPRVIESLVALHSATPEELRSGQDILRDKTKTLSDLEEIGRRNFQAVYGSSANAVRGLMESAYPDLAWFCATVAYGISYDAGVLTPAELSYGTVAVLISTDAPRQTQWHLANARNVGAPVGEIKAVREIAMKVALRAGIKWKEPVPEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J933</accession>
    <name>A0A2H3J933_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-hydroxyisobutyryl-CoA hydrolase</fullName>
            <ecNumber evidence="2">3.1.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WOLCODRAFT_15142</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-methylpropanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20888"/>
            <dbReference type="ChEBI" id="CHEBI:11805"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57340"/>
            <dbReference type="EC" id="3.1.2.4"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.1.2.4" evidence="2"/>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH34158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J933"/>
    <dbReference type="STRING" id="742152.A0A2H3J933"/>
    <dbReference type="OMA" id="TENTVHM"/>
    <dbReference type="OrthoDB" id="1737613at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003860">
        <property type="term" value="F:3-hydroxyisobutyryl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045004">
        <property type="entry name" value="ECH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032259">
        <property type="entry name" value="HIBYL-CoA-H"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43176:SF3">
        <property type="entry name" value="3-HYDROXYISOBUTYRYL-COA HYDROLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43176">
        <property type="entry name" value="3-HYDROXYISOBUTYRYL-COA HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16113">
        <property type="entry name" value="ECH_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl-CoA hydratase/isomerase" evidence="4">
        <location>
            <begin position="39"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Enoyl-CoA hydratase/isomerase" evidence="4">
        <location>
            <begin position="195"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PCH34158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="329" mass="35958" checksum="9DFB36DFC2946166" modified="2018-01-31" version="1">MQPETTAMERVAAIQRHLMSRLAAADLDDEEWIVLGTPCVIVGAGNGRAFCAGGDIELCIVNISQPETRADGMDADVLDPRYELDYILTNMPLPYIVIMDGATMGAGAGLTAGAAFRIATEHTVFAMPEVQIGYCPDVGCSHFLTRADGEIGTYLALTSESLQGQSVYEHGFATHYILSENIPNGLRSHLSGGIRAALDSAFRYHTVEQIVEELTQYAKHSADQDVRRWAARTLKTLSTRSPTSLKVSLALLRRGKNMPLLDALQMELNMTTAYCNGSDPNIFVGSNAMLDGQLGQRLPWYPDTLEKVSDTYIQENFFPKYSPDKGTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J950</accession>
    <name>A0A2H3J950_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_16056</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH38750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J950"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH38750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="175" mass="19623" checksum="B2A0887FF8BC235A" modified="2018-01-31" version="1">MSAASRCKGATNRWKRSTTSSRAGISDLLGVDARLCRWPTGAFMLLPVFGQSLVILSSTDVIAELLENRSAIYSDNGRVCRLHNHHTVQYGSRLRESRKIMIGKPNPWNAHMLKEMRAIHLLTKSLRQFCLHSSSEVTAEVATRFVASAAFQITITYGYNFKHLDDQLVQWAGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JA54</accession>
    <name>A0A2H3JA54_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pre-mRNA-splicing helicase BRR2-like plug domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_159573</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467957">
        <property type="protein sequence ID" value="PCH39120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JA54"/>
    <dbReference type="STRING" id="742152.A0A2H3JA54"/>
    <dbReference type="OrthoDB" id="2796406at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048863">
        <property type="entry name" value="BRR2_plug"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21188">
        <property type="entry name" value="BRR2_plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pre-mRNA-splicing helicase BRR2-like plug" evidence="2">
        <location>
            <begin position="118"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH39120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="289" mass="32195" checksum="289BF4F76ED07339" modified="2018-01-31" version="1">MAWGIERLPSSTATTLCTLYHVQDLSSYSHATISSLVLTADRSALLRCDKEPDGAPTSLAGTWKDLEEEEEKKAMDKQDTSERQPKRRAEATGFGYMDIIEATQDVEGLTYHPRTAETRQVYELILSSVHQSLGDQAHDVIRSAADTVLETLKNENMKDFDKKEVEEVVGPISSETFSQLLNLSKKITDHGAEDKMQVDPHLERKNAEIDEEMGVAVVFNEEEEGFEIRDESDEENEEAEEMEEAPPSHSKEMRNSLLGCQISDVYPDPVTATEEAAAILSILGSESNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JAX7</accession>
    <name>A0A2H3JAX7_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_156599</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467865">
        <property type="protein sequence ID" value="PCH35899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JAX7"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH35899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="305" mass="32641" checksum="A0FDC38700B8EC22" modified="2018-01-31" version="1">MNPSKQLSPSPVPQYPMPFKFLHFHTSAVRDTLLEEGTSPTQNSQEPQESEDIEMQEESPHYPAWGFNPVVLLPVTSTATSATATATTATSATATSTALVTSVALVTSVTATSTTVTSATMTSATLATSAAATSTAATFTTSATLATVASATTTAPASRAEYPEWNFDPSVLLRNTSTVTAETTTSKPYYPEWSFDPAVLLSSTSAKTAAAAAPSRTVKSAMRQTRKVYKRSTRAIDKSADLDDEAAPGPSSSGRKWVCFVAEDEVARYKILDRVQENMDSLYDMSDGTPPSYYSSVRHRLWKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JBE0</accession>
    <name>A0A2H3JBE0_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Small nuclear ribonucleoprotein E</fullName>
            <shortName evidence="12">snRNP-E</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Sm protein E</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">WOLCODRAFT_111545</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Involved in pre-mRNA splicing. Binds and is required for the stability of snRNA U1, U2, U4 and U5 which contain a highly conserved structural motif called the Sm binding site. Involved in cap modification.</text>
    </comment>
    <comment type="function">
        <text evidence="11">Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH33267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JBE0"/>
    <dbReference type="STRING" id="742152.A0A2H3JBE0"/>
    <dbReference type="OMA" id="VPPINCI"/>
    <dbReference type="OrthoDB" id="429711at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01718">
        <property type="entry name" value="Sm_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000013">
        <property type="entry name" value="Small nuclear ribonucleoprotein E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027078">
        <property type="entry name" value="snRNP-E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11193">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8 12" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 12" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7 12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 12" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="13">
        <location>
            <begin position="18"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00058057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PCH33267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="87" mass="10158" checksum="25C0E8C89CDB603F" modified="2018-01-31" version="1">MSGRQQRVMVQPINVIFKNLQQRAKVVIWLYDNIEMRIEGRIIGFDEFMNVVIDEAAEVYVKDAKPRRELGRILLKGDTITLIQQVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JBM0</accession>
    <name>A0A2H3JBM0_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Plasma membrane fusion protein PRM1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WOLCODRAFT_134123</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Involved in cell fusion during mating by stabilizing the plasma membrane fusion event.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cell membrane</location>
            <topology evidence="2 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the PRM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KB467865">
        <property type="protein sequence ID" value="PCH36129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JBM0"/>
    <dbReference type="STRING" id="742152.A0A2H3JBM0"/>
    <dbReference type="OMA" id="NVFGWVN"/>
    <dbReference type="OrthoDB" id="10248838at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032220">
        <property type="term" value="P:plasma membrane fusion involved in cytogamy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026777">
        <property type="entry name" value="PRM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31030">
        <property type="entry name" value="PLASMA MEMBRANE FUSION PROTEIN PRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31030:SF1">
        <property type="entry name" value="PLASMA MEMBRANE FUSION PROTEIN PRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0184">Conjugation</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="302"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="404"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="610"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="682"/>
            <end position="720"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PCH36129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="986" mass="108624" checksum="5024F06742D5FB88" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JC38</accession>
    <name>A0A2H3JC38_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PLP-dependent transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_97792</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468053">
        <property type="protein sequence ID" value="PCH39756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JC38"/>
    <dbReference type="STRING" id="742152.A0A2H3JC38"/>
    <dbReference type="OMA" id="VCIFDVV"/>
    <dbReference type="OrthoDB" id="5978656at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43092:SF2">
        <property type="entry name" value="HERCYNYLCYSTEINE SULFOXIDE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43092">
        <property type="entry name" value="L-CYSTEINE DESULFHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="2">
        <location>
            <begin position="32"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH39756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="415" mass="46372" checksum="229B75E7AECCC010" modified="2018-01-31" version="1">MASAPEFGHALLPYFALDPTFVNLNHGSFGALPKPVLEECSKLTLEVEANPDYFLRVEFEPRLNEVRRRVAALLGADTDEVVLVPSVANGMNTVLRNFEWNEGDVIVPTSTTFDSITRAVNYISSLRPNPSTSKFNLTFPTSHAQILTDFRAHLRSIKRAPNAKVVAVLDSIVSGPGVVLPWREMVEICKQENVWSVIDAAHSIGHEVDINLTKAAPDFFVTSLHKWLYAKRACAVLYVPARNQHIIKSSLPTACNYNALTPNKFSSTFVSEFLWFGAIDVVPALSNIPALEFREWLGGEKKINDYCRSLALAGGKRLAEVMGTTIMDSPNSGELTLNMVNVEIPLPGDIKPSPQIYNMWLEKLMKQRKVFATQFYHNGKWWTRASAQVYNEIEDFEKLGKALEEVCKEIVESQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JC89</accession>
    <name>A0A2H3JC89_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_159628</name>
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    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468007">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JC89"/>
    <dbReference type="STRING" id="742152.A0A2H3JC89"/>
    <dbReference type="OrthoDB" id="3062869at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH39501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="103" mass="11327" checksum="53BD736226C75A34" modified="2018-01-31" version="1">MRGSRFADGAHISSAGITISKRRNRLKADVVEALQFLKCSIRRDLLFRNSPSLLTEPDAVDETGEPSQSSEAPWDEVVEGLSDSYGTEILGDDDDDVYVPLIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JCM0</accession>
    <name>A0A2H3JCM0_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GroES-like protein</fullName>
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    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_141186</name>
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    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467987">
        <property type="protein sequence ID" value="PCH39325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="742152.A0A2H3JCM0"/>
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    <dbReference type="OrthoDB" id="3233595at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="13"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH39325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="347" mass="36214" checksum="F89C3E7C3B4CE43F" modified="2018-01-31" version="1">MSQKSLLLTAKQGSFAVGTTPIPKPGPGQVLIKIQSAALNPVEWKIQAYGLFIEKFPSVLGSDIAGTIEAVGEGVTGFAKGDRVLNQGTRGDNNEFSGFQQYALANADVTAKIVSSLSFDQASTVPVGLATAAVGLFNQGKSNSAGLYPPWEENGSGRYAGQPIVIFGGASSVGQYVIQVAKLAGFSPIITTASLTNADYLRGLGATHVLDRKLSAEQLKAQVSSITSASIQIVYDAISEADTQVAAYDLVSSGGTLVLVLANSIPESKRTSDRKIVNVFGNVNAPDNRATGASLYKQLTRLLENGSIKPNRVEVLPNGLQGIVDGLKKLQAGVSNIKLVAHPQETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JD57</accession>
    <name>A0A2H3JD57_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_139979</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467854">
        <property type="protein sequence ID" value="PCH35618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JD57"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH35618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="86" mass="9743" checksum="04073C1BDEE4509A" modified="2018-01-31" version="1" fragment="single">PPLHCRRLLYLGDVQACSILAPRRRSSLPDGSDTQIHSRCDEFFPSAHALHESARRLSWPAPRLPYVSLVLPALSIKRILSTRIRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JD96</accession>
    <name>A0A2H3JD96_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WOLCODRAFT_148740</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH37783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JD96"/>
    <dbReference type="STRING" id="742152.A0A2H3JD96"/>
    <dbReference type="OMA" id="FAPLMHI"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016652">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19120">
        <property type="entry name" value="AKR_AKR3C2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044494">
        <property type="entry name" value="AKR3C2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF3">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="7">
        <location>
            <begin position="17"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="6">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PCH37783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="299" mass="32381" checksum="2BCCEF29171E4A9D" modified="2018-01-31" version="1">MAPLTIPLNDGTSIPWLGFGTGTVHYQKDASGTLTTALAHGIHHLDTAQVYGNEDSLAPAIAASGLPRESLYITTKLLVLPPGKTVRDVLAESLRKMGVEYADLLLVHSPYAFGDRLVQVWAETEDAKAAGLARSIGVSNFEVEHLQKIISTARVVPAVNQIEYHPYVFQANVATLEYMRAHGIVPASYGCFAPLMHIKGGPVDPVLAAIAERLSKDTGKQVSLGQILHLWLRARGIVAITTSTKEERIKEYVATAELPDLTGDELRAIDEAGSQKPHSVYANFINPEAIRKYVAQALQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JDX0</accession>
    <name>A0A2H3JDX0_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Dynamin-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">WOLCODRAFT_162358</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB468053">
        <property type="protein sequence ID" value="PCH40442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH40850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JF48"/>
    <dbReference type="STRING" id="742152.A0A2H3JF48"/>
    <dbReference type="OMA" id="PEHGKQG"/>
    <dbReference type="OrthoDB" id="2567806at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1250.10">
        <property type="entry name" value="Ribosome maturation protein SBDS, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036786">
        <property type="entry name" value="Ribosome_mat_SBDS_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019783">
        <property type="entry name" value="SDO1/SBDS_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01172">
        <property type="entry name" value="SBDS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89895">
        <property type="entry name" value="FYSH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS N-terminal" evidence="2">
        <location>
            <begin position="6"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH40850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="124" mass="13289" checksum="DBE10A4C213BE77E" modified="2018-01-31" version="1">MVRPITKVVYKPDSQSTDEYTVVVNPSEYKKWLEGATTIPLADVVDSFQVFFSNQGAQGILGTPSRQQLENEFGTSKDVDVIEQILRKGQEQSGKGVTSGIVGQNAGKGSAVIDTRGKSLSGVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JFS3</accession>
    <name>A0A2H3JFS3_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DIS3-like exonuclease 2</fullName>
            <ecNumber evidence="5">3.1.13.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WOLCODRAFT_24440</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the RNR ribonuclease family. DIS3L2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.-" evidence="5"/>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH41040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="742152.A0A2H3JFS3"/>
    <dbReference type="OMA" id="QIQATHQ"/>
    <dbReference type="OrthoDB" id="372421at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990074">
        <property type="term" value="P:polyuridylation-dependent mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.690:FF:000001">
        <property type="entry name" value="Cell wall biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.700:FF:000002">
        <property type="entry name" value="Cell wall biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03045">
        <property type="entry name" value="DIS3L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041505">
        <property type="entry name" value="Dis3_CSD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028591">
        <property type="entry name" value="DIS3L2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041093">
        <property type="entry name" value="Dis3l2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022966">
        <property type="entry name" value="RNase_II/R_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050180">
        <property type="entry name" value="RNR_Ribonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355:SF9">
        <property type="entry name" value="DIS3-LIKE EXONUCLEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355">
        <property type="entry name" value="RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17877">
        <property type="entry name" value="Dis3l2_C_term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17849">
        <property type="entry name" value="OB_Dis3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01175">
        <property type="entry name" value="RIBONUCLEASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RNB" evidence="7">
        <location>
            <begin position="887"/>
            <end position="1224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="460"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="750"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="51"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="73"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="152"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="165"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="218"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="754"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="899"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="908"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="5">
        <location>
            <position position="907"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PCH41040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="1460" mass="159883" checksum="46D7E0BF9C4C96C6" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JG01</accession>
    <name>A0A2H3JG01_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_131710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
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    <dbReference type="OMA" id="IFFTFCR"/>
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH41116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="368" mass="40529" checksum="8372BD883F0A77EC" modified="2018-01-31" version="1">MLILRLAVQRSALFLSHLTPLLGIWTGGVVNVRGISVIAFCSTITSPGLQQIGKQVRKMIIDFDDVRPTRAGLELVSAALSLLTNLTDLTLMGLPSDNDGWILRGAPFSLDRFVTNLPLVSKDVLDFLARQPNVTELGTTSPPPHTAQPQPQGTYQYYPFPNHIAPRLTTLDCPAPFLLSLLAATPPTRPLTSLRVDLNRMHSLVEGDALTALALFSGTVERLSLRRSVLRTSPISDSMVAMNMASVISRVATKRHWPKLRFLEMRDGKYNSTTIPSLAQSISTCFPHVEVLVWAPASHPAGSKVVAPFIASIFFTFCRSLRRFVFLEDASDLQNKKFVSVVKQEGGQCRGTSVDAEDVENMWRSNTF</sequence>
</entry>
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    <accession>A0A2H3JG66</accession>
    <name>A0A2H3JG66_WOLCO</name>
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        <submittedName>
            <fullName evidence="3">Alcohol dehydrogenase</fullName>
        </submittedName>
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        <name evidence="3" type="ORF">WOLCODRAFT_146748</name>
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        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Agaricomycetes</taxon>
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            <taxon>Phaeolaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
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    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="PGDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
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        <property type="entry name" value="ADH_N_2"/>
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    <dbReference type="InterPro" id="IPR020843">
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        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205:SF7">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16884">
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="28"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
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    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH38833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="348" mass="37978" checksum="21141ED4D8530018" modified="2018-01-31" version="1">MAPISNGRLFFNEIPTGLPEPGKTTVYDTSETIDLDETSLGGGFLVKTLVLSIDPYQRGKMRDPNEQSYSAPYIIGEPLYNYGVGVVLRSEHPGIKPGTHLYGTMPFQQYFIRNESEKFTVLQDRIVGDEHNLPWSAYVGVCGMPGQTAYHGWKEFSKAKQGEIAFVTAGAGPVGSMVIQLAKRDGLKVIASAGSEDKVAFLRKIGTDVAFNYKTEKTLDVLQKEGPIDVFWDGVGGETLEAAIEAAARGARFIECGMISAYNGGVPYHVKNLTYIMSKELKISGFVVSSLHAKYLDEFYRQIPPMVARGELLYTEDIASGLENAGQAILDVQTGRNKGKSVVVVAQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JGA2</accession>
    <name>A0A2H3JGA2_WOLCO</name>
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            <fullName evidence="2">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
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        <lineage>
            <taxon>Eukaryota</taxon>
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    <reference evidence="3 4" key="1">
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            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
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                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
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                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </feature>
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            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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        </source>
    </evidence>
    <sequence length="543" mass="60812" checksum="7CDFEF5B5F4F3C4E" modified="2018-01-31" version="1"> </sequence>
</entry>
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    <accession>A0A2H3JGV1</accession>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Barry K."/>
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                <person name="Martinez A.T."/>
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                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
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                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
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                <person name="Ferreira P."/>
                <person name="Findley K."/>
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                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
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                <person name="Heitman J."/>
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                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
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                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
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            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH41111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JGV1"/>
    <dbReference type="OMA" id="EWYVNIS"/>
    <dbReference type="OrthoDB" id="196650at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF31">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="309"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="338"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="452"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="8"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="228"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="235"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PCH41111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="479" mass="51195" checksum="4509CE0D4D0C6B3D" modified="2018-01-31" version="1">MAKVERVVFLSLVLDLFAFTIPLPLFPRIIEWYTKREASDPSGFLSRTLYFVSAVRGLLYKPTSNPQRWDVVLLGGLMGSIFSFISPHIGSLSDKHGRKKILLLTMVGNILSALIWVKSTTFASYMLSRIVGGLSEGNVQLAIAILSDVSTPATRAKALAHVGIAFAICFCIGPPIGAYFASRPLPPSFTASGIELNVYATPALLTLVLLVLETIFLAVALPETRGKRAQAPEQTKQDLTEKKPEQTSKAGESVESHSAPNVSVEQRLALLKTLRRLHFLFLGVFSGVEFTLTFLTYDLFDWNNRQNGILIGGIGIVSALLQGGYVRRSIAKVGEGAMAHRGVVSCALGLVLLAAMPSFVTSRPGAALRLLQAAAVCMGFTSATVVNALTAYASLQCDDGVDADTGKPREEHPQLAKGRALGQFRSSGQLGRAIGPLLACASYWTFGPSVTYAASAVAMFALSAGTRVLARRKTASVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JHC2</accession>
    <name>A0A2H3JHC2_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_137485</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH41590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JHC2"/>
    <dbReference type="OMA" id="RKKNHEY"/>
    <dbReference type="OrthoDB" id="2149705at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH41590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="160" mass="18238" checksum="EA7492F6A2C3B553" modified="2018-01-31" version="1">MPAVRSRKANSVAAQNDAFTTERQARVSTDVILTIKPLFATLLSKREKNYEFRSYKLREEVKRFWLYESSPSRAIRYIIETAAPKTPGELRDPSGVGNDAFDAGALTKYAYPVCAMYKLAQPLTRDALHARFGTKSPQGFCYAPHRLIEELPLDQMERLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2024-11-27" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JHX7</accession>
    <name>A0A2H3JHX7_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Complex III subunit 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WOLCODRAFT_161511</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UQCRB/QCR7 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH38359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JHX7"/>
    <dbReference type="STRING" id="742152.A0A2H3JHX7"/>
    <dbReference type="OMA" id="PLAQWYT"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045275">
        <property type="term" value="C:respiratory chain complex III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1090.10:FF:000001">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1090.10">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003197">
        <property type="entry name" value="QCR7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036544">
        <property type="entry name" value="QCR7_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12022:SF0">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12022">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX 14 KD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02271">
        <property type="entry name" value="UCR_14kD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81524">
        <property type="entry name" value="14 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PCH38359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="127" mass="15171" checksum="AD634063972C39D4" modified="2018-01-31" version="1">MVLGPLGPSLAPSVLKNRSLYRWVKPVADWYVNLSGWRRVGYKYDDLIPEERPDVERALSRLTPREAYDRQFRLKRASHCSVLHDILPKDQWTKPEEDVRYLTPHIENVEKEEQERRAWDNMAIERK</sequence>
</entry>
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            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
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                <person name="Yadav J.S."/>
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                <person name="Benoit I."/>
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                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
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                <person name="Hori C."/>
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                <person name="Jurgens J.A."/>
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            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_uS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018079">
        <property type="entry name" value="Ribosomal_uS4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="30S 40S RIBOSOMAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF4">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US4M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55174">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RIBOSOMAL_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="RNA-binding S4" evidence="8">
        <location>
            <begin position="134"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="192"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="210"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PCH42006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="346" mass="39328" checksum="C3E66383488D7163" modified="2018-01-31" version="1">MRDANVYSIRRAMPRMSWHPQNLYNLWRRSLGGKRLETDFTSSTKSLFQQRWASKALLRAYHGDFINEKIFKRWYLPETLPDVRSQASRIANAASMNKWARRDQTADREAKRLENEAAKGLAPVGSLMFREVERRIDVIVFRSCFAHSVYEARRLVIHGDVLLNGKKHTNPNTRLAPGDMITVDPKAIRFLRPSAAPKPDSEAAATDSTSIEEEASTDTENPEANHSESVEQAAPSSSEADMAKHAVLPAKSKNWKRADPKKNLTPFSLPPYASPSIFIPAYIEPSFATCSAIYVRHPTARPGYSEIPTPYDADGEVIRAAWEWYTRVRPRMRSKSQLARMPENRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JIV8</accession>
    <name>A0A2H3JIV8_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WOLCODRAFT_95626</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH37678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JIV8"/>
    <dbReference type="STRING" id="742152.A0A2H3JIV8"/>
    <dbReference type="OMA" id="ARIWNEQ"/>
    <dbReference type="OrthoDB" id="429967at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008554">
        <property type="entry name" value="Glutaredoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052115">
        <property type="entry name" value="NEXT_complex_subunit_ZCCHC8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13316:SF0">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13316">
        <property type="entry name" value="ZINC FINGER, CCHC DOMAIN CONTAINING 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05768">
        <property type="entry name" value="Glrx-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="163"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="89"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="313"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="386"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="337"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="386"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="398"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="427"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PCH37678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="474" mass="53153" checksum="F52772E72A75B2DD" modified="2018-01-31" version="1">MASRGVGRMARLTLFSGPNCSLCDIAKAELVKVRQQRSFDLETINIQDAGQERWKRKYVYWIPALHVEGREVAKGRWNAETVNSALDLWEKDPWTKDEPSAGAGKPHSQQQQQQMVPLYVEDLHRNGNTQDEDCGSGYYLYERCGETALGLSQDEDIGHIDERRCFNCGLPGHMISSCPEPRNHALITLSRQLFNFFKGDNASNGNQRVHEVERWRQQRLEWLETFEPGQIRGSLLRDALDLKDGDAGENVEWLRNMCIWGYPKGWYASVDPRERIWNVLSGGDDGDDSSEYAIDDFMFDIVGEDSVERLVLPSKVKPHARDTESNASDSDSESDPELSSASSRSSTPSSRAQPAPQRWAAYPLTYFLWSRLPIYNGLSLPSPQSIRNAPRQSSVYEYPPPPCTTPPPLPSAEAPVARYESQYPVEQYPPPPPPTVPPPLPPMMPPPAMLLPFPAAAPPTHHTALLSIPHSAPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JJX0</accession>
    <name>A0A2H3JJX0_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WOLCODRAFT_136008</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH38048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JJX0"/>
    <dbReference type="STRING" id="742152.A0A2H3JJX0"/>
    <dbReference type="OMA" id="WRATFDT"/>
    <dbReference type="OrthoDB" id="66144at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <location>
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        </location>
    </feature>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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</entry>
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            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
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                <person name="Benoit I."/>
                <person name="Boyd A."/>
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                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
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                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
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                <person name="Morin E."/>
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                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
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                <person name="St John F."/>
                <person name="Stenlid J."/>
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                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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        <location>
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        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH41995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
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                <person name="Lundell T."/>
                <person name="Martin R."/>
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                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="RTA1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF9">
        <property type="entry name" value="SPHINGOID LONG-CHAIN BASE TRANSPORTER RSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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    </feature>
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            <end position="155"/>
        </location>
    </feature>
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        <location>
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    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH39359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="320" mass="35528" checksum="6C438378AE665095" modified="2018-01-31" version="1">MELEGMDSGSSFNGTQASNVPESPYGYVPTAWVGILFVTLFGASTICHLIQAIHYRLWWLFPTVLLAGCMEIIGWIGRLWSSYNVLLNTPYMIQIILTILAPTPLVAANFIMLGKCIQRLGQQYSRLSAKQYTAIFLSCDIIALLVQGAGGGIASSSVGSGTSPDLGGNIMLGGIIFQLVAITLYVFLATEFVLRYLHNRPLKNRMNTTTSYYLDSRMKQMLMALAFSSLCIYIRSWYRTIELANGWRGYIIRTQRYFVIMDALMIVLAMGVINIFHPGRLLGSAEIWKESMPMADIRGSIVPADPDYVALRGNMSTPEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JKW1</accession>
    <name>A0A2H3JKW1_WOLCO</name>
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        <lineage>
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    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
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                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
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                <person name="Boyd A."/>
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                <person name="Ferreira P."/>
                <person name="Findley K."/>
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                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
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                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
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                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468135">
        <property type="protein sequence ID" value="PCH42846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JKW1"/>
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        <location>
            <begin position="40"/>
            <end position="86"/>
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        <location>
            <begin position="274"/>
            <end position="301"/>
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    </feature>
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        <location>
            <begin position="1"/>
            <end position="42"/>
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        <location>
            <begin position="686"/>
            <end position="721"/>
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    </feature>
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        <location>
            <begin position="746"/>
            <end position="845"/>
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    </feature>
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        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
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        <location>
            <begin position="688"/>
            <end position="701"/>
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        <location>
            <begin position="746"/>
            <end position="763"/>
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    </feature>
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        <location>
            <begin position="768"/>
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        <location>
            <begin position="787"/>
            <end position="804"/>
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    </feature>
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        <location>
            <begin position="805"/>
            <end position="819"/>
        </location>
    </feature>
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        <location>
            <begin position="825"/>
            <end position="845"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH42846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="885" mass="96266" checksum="47762DB556541CE3" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JLL7</accession>
    <name>A0A2H3JLL7_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein-S-isoprenylcysteine O-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WOLCODRAFT_110050</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + S-adenosyl-L-methionine = [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:21672"/>
            <dbReference type="Rhea" id="RHEA-COMP:12125"/>
            <dbReference type="Rhea" id="RHEA-COMP:12126"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90510"/>
            <dbReference type="ChEBI" id="CHEBI:90511"/>
            <dbReference type="EC" id="2.1.1.100"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.100" evidence="5"/>
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        <property type="protein sequence ID" value="PCH37534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JLL7"/>
    <dbReference type="STRING" id="742152.A0A2H3JLL7"/>
    <dbReference type="OMA" id="YAKIFLH"/>
    <dbReference type="OrthoDB" id="422086at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004671">
        <property type="term" value="F:protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007269">
        <property type="entry name" value="ICMT_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12714">
        <property type="entry name" value="PROTEIN-S ISOPRENYLCYSTEINE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12714:SF9">
        <property type="entry name" value="PROTEIN-S-ISOPRENYLCYSTEINE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04140">
        <property type="entry name" value="ICMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
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            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
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            <end position="171"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PCH37534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="234" mass="26149" checksum="0B9EDE357522C2E8" modified="2018-01-31" version="1">MQPILLKAPLLLAGAFGVHIGLTDPNPSVPRTDMQRFGVSDIASQTQKWQTLLTRVSCCEILAILAALQIKGMPDWLAHYLIPRGTVVVDHLHITPIFITGILLQVLGAAFRIACYRTLGRHFTYVLSMREDHKLVTAGPYSIVRHPSYTALIMQYIGTLMVHLGEGSWLIEGGILDSVVGRIAMGAWVADAIALWIMMISRTDREDRTLKEKFGAQWVQWSKQTPYRLVPGIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JLZ1</accession>
    <name>A0A2H3JLZ1_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_148603</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH37654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JLZ1"/>
    <dbReference type="STRING" id="742152.A0A2H3JLZ1"/>
    <dbReference type="OMA" id="ESHRYEV"/>
    <dbReference type="OrthoDB" id="8922241at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH37654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="134" mass="15411" checksum="A0B9C0F275B82E84" modified="2018-01-31" version="1">MQVHISTDEFQTMLKAALETLRCPLDGCDYVQEPPLRSQDMRRHLESHRSNKNRQKWVCCGVPREHMAVYGVTVPYNTITFKGIEMVNGCLRTFSRRDALVRHIKTQNNQCLAEEGFWHLLHAPEPPDSSASAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JMP6</accession>
    <name>A0A2H3JMP6_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Small heat shock protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WOLCODRAFT_102592</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468135">
        <property type="protein sequence ID" value="PCH42765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JMP6"/>
    <dbReference type="SMR" id="A0A2H3JMP6"/>
    <dbReference type="STRING" id="742152.A0A2H3JMP6"/>
    <dbReference type="OMA" id="WRETENA"/>
    <dbReference type="OrthoDB" id="1431247at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06464">
        <property type="entry name" value="ACD_sHsps-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031107">
        <property type="entry name" value="Small_HSP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11527">
        <property type="entry name" value="HEAT-SHOCK PROTEIN 20 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="4">
        <location>
            <begin position="45"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="CS" evidence="5">
        <location>
            <begin position="49"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PCH42765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="158" mass="17947" checksum="24827567756DE1B8" modified="2018-01-31" version="1">MSLTSFFYQPFYSLADFDRLFNEAFSARTNPTNTNGDHQVQRQEPSSRFLRPRMDLHEDIGQNIVTATFELPGINKENVQIDVHNGVLNVSGESRLFSDRDENGYAVRERRYGKFSRAIPLPQGIKSEDIKASMENGILTVTFPKTTPETASKRITIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JMQ8</accession>
    <name>A0A2H3JMQ8_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_141049</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467954">
        <property type="protein sequence ID" value="PCH39018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JMQ8"/>
    <dbReference type="STRING" id="742152.A0A2H3JMQ8"/>
    <dbReference type="OrthoDB" id="2804496at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH39018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="342" mass="36387" checksum="936F9D32DF478364" modified="2018-01-31" version="1">MAQASTSRSRPMLALGMTRSLTQQGSTRLPMRPSGDKFAERMKRQREQEEEQRLQDLADVAMTAEQFASLQRSFADVKVEFADLDGLSWGTPEAQCLLARWYKSQVMALRRAGPPDVGRDCTPRSPSRHAALAQPSAAGLGSAHATIRAGRTARFPPCLPLAPPPLTLPAGLREYIDAVAAGLITNNPPATSKLTQRRLQLPPHRVFSLPPRVPPSMPAMARETTVRPAVLTSPELGAEGGGKYAGLGGVRRMPGVARPVLDRSATIRPATKIGQDVASPRGAKAFRSLRVVSLPVIKLGSGPPMSRTQSCLGVQMSPPGGCRASEQPFSLAAPSSPVLACA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JNI0</accession>
    <name>A0A2H3JNI0_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SAC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WOLCODRAFT_74198</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB468135">
        <property type="protein sequence ID" value="PCH43055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JNI0"/>
    <dbReference type="STRING" id="742152.A0A2H3JNI0"/>
    <dbReference type="OrthoDB" id="405996at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043813">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043573">
        <property type="entry name" value="Fig4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45738">
        <property type="entry name" value="POLYPHOSPHOINOSITIDE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45738:SF5">
        <property type="entry name" value="POLYPHOSPHOINOSITIDE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAC" evidence="5">
        <location>
            <begin position="228"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PCH43055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="776" mass="88436" checksum="67C7BF3A9800A214" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JNV2</accession>
    <name>A0A2H3JNV2_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">ATP synthase subunit d, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WOLCODRAFT_24846</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ATPase d subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH41583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JNV2"/>
    <dbReference type="STRING" id="742152.A0A2H3JNV2"/>
    <dbReference type="OMA" id="VSKGRWA"/>
    <dbReference type="OrthoDB" id="35799at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008689">
        <property type="entry name" value="ATP_synth_F0_dsu_mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036228">
        <property type="entry name" value="ATP_synth_F0_dsu_sf_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12700">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT D, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05873">
        <property type="entry name" value="Mt_ATP-synt_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005514">
        <property type="entry name" value="ATPase_F0_D_mt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161065">
        <property type="entry name" value="ATP synthase D chain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0138">CF(0)</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0813">Transport</keyword>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="100"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR005514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PCH41583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="173" mass="19336" checksum="0D2DE024821E9D4D" modified="2018-01-31" version="1">MASKAAVAAVDFVRVYSSLGLSKETIAALQAFRKRHADAQRIHAQYASQSTTVDLTYYRSVLKNKAIVDDAEKILRDFKPVTYDVNTQIQAIETFEAKAVAKAKETTEKIDIELKDLQATLANIEEARPFEDLTAEEVGQAHPRIVEAVETMIKKGKWTVPGYKEKFGELSIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JP04</accession>
    <name>A0A2H3JP04_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WOLCODRAFT_136918</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468053">
        <property type="protein sequence ID" value="PCH40529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JP04"/>
    <dbReference type="STRING" id="742152.A0A2H3JP04"/>
    <dbReference type="OMA" id="WRSKYEK"/>
    <dbReference type="OrthoDB" id="202203at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004174">
        <property type="term" value="F:electron-transferring-flavoprotein dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735:SF3">
        <property type="entry name" value="FERROPTOSIS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00469">
        <property type="entry name" value="PNDRDTASEII"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="5">
        <location>
            <begin position="10"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PCH40529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="373" mass="40712" checksum="D1A0E2D239670018" modified="2018-01-31" version="1">MSKKTDDKQNVVVVGGGFVGSLLARALSAKLDPARYTLILINERPYMIQLIAGARMIVSDTDRLEDTALIPYDKLFVNGNGQFYQGRVEQIDEAGSAVVLKNGERISYAALILATGSTWSGPLDFPEAGADVQAHIREWRDKVERAKDIFIVGGGAVGIEYAGEIRDIFPDKKITIIHSSDMLLNSTYPDKYRRDIARRCRAIGVKLVFGEYVDQFPAPGTVGLTTRRGTSYRSADLVIPAFGARPNTRFIASLGADALAESGCVKVHPTLEVQGHPGVFALGDIIEWHEQKQAAKGGAHVPIVVENVLSFLARRPLAKQYKGSIEMILIPLGKSGGSAYLDILWGITLGAWFARMVKGKDLFVPKSRKDRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JPW5</accession>
    <name>A0A2H3JPW5_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">dUTP diphosphatase</fullName>
            <ecNumber evidence="4">3.6.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WOLCODRAFT_71967</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7 8">MD-104</strain>
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        <text evidence="1">Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2.</text>
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            <begin position="1"/>
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        <location>
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    </feature>
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        <source>
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        </source>
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    </evidence>
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        </source>
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        <source>
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    </evidence>
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        <source>
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</entry>
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    <accession>A0A2H3JQ32</accession>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
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                <person name="Lundell T."/>
                <person name="Martin R."/>
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                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
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                <person name="Stenlid J."/>
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                <person name="Sun S."/>
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                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
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                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
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    </dbReference>
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    </evidence>
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</entry>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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        <location>
            <begin position="1"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH44350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="157" mass="17426" checksum="7E76F036F2DE51FC" modified="2018-01-31" version="1">MERRLPKPSTTAYQQWTPTPARRHSDGTSPGSDVSPITVHYGHDIAPTSCRPQSTATPAFPHRTPPPARCHDGGMPLERRLHNRPTGVPTWTPPPPSRCPRLARMERRLPKPPTTVIPHRTPPPVRCHVGGVPPEQRLLNKRPLRRTNMDATSGALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JQK9</accession>
    <name>A0A2H3JQK9_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transcription factor IIIC 90kDa subunit N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_105111</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468157">
        <property type="protein sequence ID" value="PCH44432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JQK9"/>
    <dbReference type="STRING" id="742152.A0A2H3JQK9"/>
    <dbReference type="OMA" id="EERRMEC"/>
    <dbReference type="OrthoDB" id="421374at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044230">
        <property type="entry name" value="GTF3C4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024761">
        <property type="entry name" value="TFIIIC_delta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024764">
        <property type="entry name" value="TFIIIC_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15496:SF2">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15496">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 4 FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12657">
        <property type="entry name" value="TFIIIC_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="zf-TFIIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor IIIC 90kDa subunit N-terminal" evidence="1">
        <location>
            <begin position="26"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription factor IIIC putative zinc-finger" evidence="2">
        <location>
            <begin position="683"/>
            <end position="782"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH44432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="786" mass="86429" checksum="E3693B58C7B9EDB7" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JRD4</accession>
    <name>A0A2H3JRD4_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WOLCODRAFT_136777</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468053">
        <property type="protein sequence ID" value="PCH40328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JRD4"/>
    <dbReference type="STRING" id="742152.A0A2H3JRD4"/>
    <dbReference type="OMA" id="TLYCATH"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05327">
        <property type="entry name" value="retinol-DH_like_SDR_c_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF236">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013890946" evidence="4">
        <location>
            <begin position="23"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PCH40328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="327" mass="36550" checksum="D370DDDCABDC1CD3" modified="2018-01-31" version="1">MAFLHELWYSMLIMWRVFFPWGNFTVDQIPDLTGQVMIVTGGNVGIGRETIKALLQHNAKVYMASRSKEKADEAIKHLKEETGKAAIFLELDLSDLSSVRRAAKEFLSKESELHALFNNAGVMVPPIEMVTKDGYDMQFGTNVVGHHLFTQLLVPALVAGKRASPDHHARIITTSSAAAMSGFINWDTLKDGPVRRARSTRAMYAQSKLANAIVARQLAKRYADQGIISMSVDPGSIRTDLQRHAKEEFSTGIKAILLEIVFWALLRPTPFGALTQLWAGTMPEAIHHNGKYLIPTARVGTCRPEAYDDELGARLWDWLEHEVQEKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JRL3</accession>
    <name>A0A2H3JRL3_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WOLCODRAFT_26864</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD-104</strain>
        </source>
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    <comment type="subcellular location">
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Barry K."/>
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                <person name="de Vries R.P."/>
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                <person name="Gorecki P."/>
                <person name="Heitman J."/>
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                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
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            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467998">
        <property type="protein sequence ID" value="PCH39454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JS32"/>
    <dbReference type="STRING" id="742152.A0A2H3JS32"/>
    <dbReference type="OMA" id="ERSQACK"/>
    <dbReference type="OrthoDB" id="3181259at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38926:SF5">
        <property type="entry name" value="F-BOX AND LEUCINE-RICH REPEAT PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38926">
        <property type="entry name" value="F-BOX DOMAIN CONTAINING PROTEIN, EXPRESSED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="80"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="47"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH39454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="507" mass="56858" checksum="77C25C4C521C41E0" modified="2018-01-31" version="1">MDDEPVMEPLSYDELGAWDDLDSISLSDEEEGYDPCTIDPRATPPDIADIDRTMAELEAELARLRVRRAHLLAERALVTRLPAEILSRIFELGVHERTSLLSSLSLVSRHWRSVALATPSLWTYITLDNQWGLTRIPAFLRRTRACLERSQACKLVVDIDIGYMDHEELKEVMSLLQPHLVRCFDFRISAPCWDALPLVRPYLAELGPTLEQLYMRISATEAQDDTPHCTLLAQPCPRLKCIILEHLPLVCIRVPLPQLRSLFITRDQQYRRSVNRRFGVAFKELLATLTAAPHIEELRLQSVALLLDGSECIFHGTPALTRIPSLRMLTFNLVDASTVSLFLESTDLPLLERLAVGMEPAADEHMHWLPRLAPARLPALRQLDLRTCAVDGPALVPFVRALHGLPQLTGLALSCPRLGFLGTQFFDLLASGPAATGVWILPRLEALCVQQCVDVTGHELLRVVCARRGSGVPDVADIKYLKIAQCDSFDLDVLEQLHSVVETVRLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JSX2</accession>
    <name>A0A2H3JSX2_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Thioesterase/thiol ester dehydrase-isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WOLCODRAFT_138170</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acyl coenzyme A hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468135">
        <property type="protein sequence ID" value="PCH43033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JSX2"/>
    <dbReference type="STRING" id="742152.A0A2H3JSX2"/>
    <dbReference type="OMA" id="QFNYTFL"/>
    <dbReference type="OrthoDB" id="331699at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03442">
        <property type="entry name" value="BFIT_BACH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033120">
        <property type="entry name" value="HOTDOG_ACOT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12655">
        <property type="entry name" value="ACYL-COA THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12655:SF0">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51770">
        <property type="entry name" value="HOTDOG_ACOT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="HotDog ACOT-type" evidence="5">
        <location>
            <begin position="4"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="HotDog ACOT-type" evidence="5">
        <location>
            <begin position="210"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PCH43033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="364" mass="40739" checksum="F82E65E4401BE5D1" modified="2018-01-31" version="1">MHDSYCELVLPFASSPELLEQYTNASGGIRTGMLMEHLDSLAGGIAYKHMLGPTVDTLSKKHGFYIVTASVDRLDMLAPLYPVRDMRLSGQVIHTGRSSMEVAVRMEALEKDGREETIMLGRFFMVCRDAITHKATPVNPLNINTPEDQMLFSIGEAHKNKRKIRTSAALNRVPPTSSEAEELHGIYLKYGLQEGDDFVGPDGEKRVWMGDTRLEKCMMMFPQERNVHQKIFGGYLMRLAYELGFANSVLFTGGHVLFVSLDGISFAKPVPIGSILRLTSQILHTSSSEQFPGLIHVGVQANVVDVATGKEQTTNDFRFTWATDDAKPLTRRVVPKTYKEAMLWLEGRRALDMGAEIRGMRKRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JSY3</accession>
    <name>A0A2H3JSY3_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_29413</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467965">
        <property type="protein sequence ID" value="PCH39167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JSY3"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH39167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="77" mass="8075" checksum="75605EE56EDE6851" modified="2018-01-31" version="1">MAVGGGASTSTTAVAQPVPKPQEVIDLSNDLASNSDKTAAGAASQLEEFTRADSPDLAELFSDDPWSTRKIDFGYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JT78</accession>
    <name>A0A2H3JT78_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_16187</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468053">
        <property type="protein sequence ID" value="PCH39904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JT78"/>
    <dbReference type="OrthoDB" id="3265526at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="2">
        <location>
            <begin position="194"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH39904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="285" mass="31596" checksum="0ADE4DADB992E13E" modified="2018-01-31" version="1">MSSPTFSLDANSSSGCTFIGISVAIFLYGISCAQTAYYFKAYPKDSLALRSICSPPYLLFNLSNASLSGVLTPPEYVYPLHCFGPWESRDTAAFCHSYSIQLKRRNSIKSTYFGVRVLSIVTRATDQTFLLGRAGINRGNDTSSAIVAVELTGFGSGIGQYHLYRENGLLIVIPVISSSHRLPIPSLMGPLCTLLADIYITLMLTWILSKNKTGLERTNNTVTQLITFAITRGFFTAAIAQDWHRFTHLGQLVLYWLEIGSFPPKLYWVMFHFPEAGDAHHILLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JTC8</accession>
    <name>A0A2H3JTC8_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycerol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WOLCODRAFT_23746</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron-containing alcohol dehydrogenase family.</text>
    </comment>
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        <property type="protein sequence ID" value="PCH39954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JTC8"/>
    <dbReference type="STRING" id="742152.A0A2H3JTC8"/>
    <dbReference type="OMA" id="GVGTIMM"/>
    <dbReference type="OrthoDB" id="339764at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08170">
        <property type="entry name" value="GlyDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1090.10">
        <property type="entry name" value="Dehydroquinate synthase-like - alpha domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018211">
        <property type="entry name" value="ADH_Fe_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016205">
        <property type="entry name" value="Glycerol_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006941">
        <property type="entry name" value="PRK09423.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43616">
        <property type="entry name" value="GLYCEROL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43616:SF5">
        <property type="entry name" value="GLYCEROL DEHYDROGENASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000112">
        <property type="entry name" value="Glycerol_dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56796">
        <property type="entry name" value="Dehydroquinate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00913">
        <property type="entry name" value="ADH_IRON_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00060">
        <property type="entry name" value="ADH_IRON_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA" evidence="5">
        <location>
            <begin position="15"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PCH39954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="373" mass="39340" checksum="4309E9D10E9DF23A" modified="2018-01-31" version="1">MPNPNRVTEKLFQSPSKYIQGPSAIHNAGKYLSSFGTAPLLLADEIVYNIAGKELTAALEASNFKVTRGIFGGEASKDEIAQHTARGKQNKVDFVVALGGGKTIDSAKAIADDLGLQVAVLPTTASTDAPCSALSVLYRPNGEFEHYRFYSSNPTVVLVDTSVVVKAPPRFLAAGIGDALATNLEARSARNSPNFGGGLPTEVSAAIGAKCEEILFKYGKQAVEANKAKAVTPAFEAVVEANTLLSGLGFESGGLAAAHAIHNGLTAINNHTLHTKMHGEKVAFGIVCQLILDNASSSEIDRYLTLMKSVELPMTLGELGIGGATDEELHRVASLACAPNETIWNMDRVITPEIVFHAIKGADAVGREFLARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JTW3</accession>
    <name>A0A2H3JTW3_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_153459</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468146">
        <property type="protein sequence ID" value="PCH43403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JTW3"/>
    <dbReference type="STRING" id="742152.A0A2H3JTW3"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH43403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="305" mass="34510" checksum="654ED37FBEF1FACD" modified="2018-01-31" version="1">MLFDADRRMEIVEQIEAIRFEDAQNDAAECTQNIAAQTAATTNRKLQQDLEKPCKREEREREKARRQEQHDFAKACKQAQREEEKRKHDEAHKNVRAVKQFEQAQAREARHLKQEAAKAASDAKARLKEEAKTRKKSSAVEQDNGKRNDTMNAVSLSQDRPPLDEYFDDLFRESDDDDEVDDDIVKLLASLTQASDTGGPSQKDVGDGDASDSNHDDGTRDDGTHDDGNRDDGNRDADRDAESMSDAMAQDKITAVRAVFWNQDRLMPAAAIIHAVNGYVRLADFPSMLNMFGLDIDVTRVEIWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JUY0</accession>
    <name>A0A2H3JUY0_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_24171</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468053">
        <property type="protein sequence ID" value="PCH40524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JUY0"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH40524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="77" mass="8401" checksum="510FC8F4A1A62C8A" modified="2018-01-31" version="1">MIGRQRGRGVSRTLGSTAPDVLDTAVIGCEYYTSGYEITKNQWMCLQSGVGSLFAAHPPSRLLADNPQQSMSRLLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JVA1</accession>
    <name>A0A2H3JVA1_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_122810</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468146">
        <property type="protein sequence ID" value="PCH43893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JVA1"/>
    <dbReference type="OMA" id="TGWMIRT"/>
    <dbReference type="OrthoDB" id="2502792at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="89"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH43893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="209" mass="22821" checksum="6B344A6C2CDEC5B6" modified="2018-01-31" version="1">MNLIYSLLHAVKTLVSSDPSNLDTQKILPPIITLLAAYLALLSFYRTASWAIRTTLWFAKWGAILSVITAGTGWYLGNMHANGENGVGGLLNGVLPAAGGMLLNVLNGQDQDAAGSLGSTRARSPRPKAWESWDKHQEWQYHDNARDEDHGAEGDLQQVFREVIGVVGRTVNEGSWWEAAKGAVDEISRGRQGRETRAERRAQAKAGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JWT2</accession>
    <name>A0A2H3JWT2_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WOLCODRAFT_139009</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468157">
        <property type="protein sequence ID" value="PCH44433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JWT2"/>
    <dbReference type="STRING" id="742152.A0A2H3JWT2"/>
    <dbReference type="OMA" id="CAEWRVR"/>
    <dbReference type="OrthoDB" id="425534at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013595">
        <property type="entry name" value="Pept_S33_TAP-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051601">
        <property type="entry name" value="Serine_prot/Carboxylest_S33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248">
        <property type="entry name" value="2-SUCCINYL-6-HYDROXY-2,4-CYCLOHEXADIENE-1-CARBOXYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248:SF25">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08386">
        <property type="entry name" value="Abhydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="4">
        <location>
            <begin position="133"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S33 tripeptidyl aminopeptidase-like C-terminal" evidence="5">
        <location>
            <begin position="471"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PCH44433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="615" mass="67440" checksum="B1AB7073CC65351B" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JX59</accession>
    <name>A0A2H3JX59_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Response regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WOLCODRAFT_162982</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD-104</strain>
        </source>
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339:SF1">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="133"/>
            <end position="261"/>
        </location>
    </feature>
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            <end position="79"/>
        </location>
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            <end position="177"/>
        </location>
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            <end position="218"/>
        </location>
    </feature>
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        <location>
            <begin position="244"/>
            <end position="267"/>
        </location>
    </feature>
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        <location>
            <begin position="285"/>
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        </location>
    </feature>
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            <begin position="1"/>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="293"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="352" mass="37876" checksum="2B5723FB5AF1CE4D" modified="2018-01-31" version="1">MSSARPARDQADRGGTPEAGTGARRAANPKPAARDATRTTALQRERISELGARGEPDGRLGELQEEVVLRPERDNEDGRAVARGGVRGRMLGKRVVGTSPVRGGAARQLAAFAVWTVSRLRRSQAGRPSIVPPISVTDDNPINQTILSTFMEKKKIKSDMPRTAKKRSRSGGPVVSSSSWCMDIQMPVVDGIEATRKIRRKDKASTTESRSSATSTPPYRPSVVIVALTASSLQSDHRSRQQYLSVKMADPESPAEDGHWEEVMPARSAQELAATDIDAAALDAVHHGVTDSAGGEPAAAPLEAQRSSARPKRETSRRPRSQLSPPVSRLSRRRLKSPNDGAGRPLDGSHCL</sequence>
</entry>
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        <lineage>
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            <taxon>Agaricomycetes</taxon>
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            <taxon>Phaeolaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF564">
        <property type="entry name" value="STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <begin position="9"/>
            <end position="265"/>
        </location>
    </feature>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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    </evidence>
    <sequence length="345" mass="38700" checksum="8D895316D9C3729C" modified="2018-01-31" version="1">MPAVTRGKVLVTGANGFVAAWVVYDLLKQSYSVRATVRSENKSTHLRNVFGSYGDRLEIVVVEDITKEGAFDEAVQGVDAIEHIASPCHPGTDDPQDMIIPAVNGTLGILQSARAHGSNVQRVVITSSCATIAEYTNPPRVFTEYDWNEKAVVEVKAKKRDAHPISKYRASKVLAERAAWNFVEEHKGDLQWDLVVLCPSYVFGPMIHEVKSLDTMNASMNGWYQWALKGLFDPTRLDIEGFNWVDVRDLANAHVLAIQKMEAAGSRVIVSQGPWDWYECIDVCRQCGVETPVKEQRPRATAIPHQWTYDTSKAEKILGIRFRSLRDSTNDIIQDLRSKGWIEVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JY20</accession>
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    <protein>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
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                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
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                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468135">
        <property type="protein sequence ID" value="PCH42758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JY20"/>
    <dbReference type="STRING" id="742152.A0A2H3JY20"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH42758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="135" mass="15474" checksum="F929BB61B97C34FA" modified="2018-01-31" version="1">MKKIVELLWLYILKFYMLVFYFVHMLGLLYVNFMMYKLAVAMSHITLTPVQCIPTSTAGEGMSKEEETWFSKLTVFSDCFGCKGVEIDSAAAWYEHPDEGALVLEWCEQLYLVLVERKKKSGQRMGNGDEHAASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JYH2</accession>
    <name>A0A2H3JYH2_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">chitin deacetylase</fullName>
            <ecNumber evidence="12">3.5.1.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">WOLCODRAFT_31035</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + n H2O = chitosan + n acetate</text>
            <dbReference type="Rhea" id="RHEA:10464"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9597"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57704"/>
            <dbReference type="EC" id="3.5.1.41"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:10465"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.5.1.41" evidence="12"/>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH41197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JYH2"/>
    <dbReference type="STRING" id="742152.A0A2H3JYH2"/>
    <dbReference type="OMA" id="GDIWDAP"/>
    <dbReference type="OrthoDB" id="407355at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004099">
        <property type="term" value="F:chitin deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050248">
        <property type="entry name" value="Polysacc_deacetylase_ArnD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587:SF135">
        <property type="entry name" value="CHITIN DEACETYLASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587">
        <property type="entry name" value="GLYCOSYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="8" id="KW-0170">Cobalt</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="14">
        <location>
            <begin position="118"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PCH41197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="307" mass="33600" checksum="FCE4B9013BF9F740" modified="2018-01-31" version="1" fragment="single">RRSSGEWYHADGHPAYALFRRQDSNETTDGIAYAQVGSPTWLAAFPTSSPDPSNLPQAWVDALDGAVSAGKIPDIPQSTMSPDGNPVYPDSLDPTGPEVCSGTYKCQIDDDIWDAPDGVVGAGFDDGPLPTSTQLYEFLAEQGVHATHFMIGVNILWNSDEFLMAFQTNQDDIAVHTWTHPYMTTLSNLQIVSELGWTMQLIHNSTGGRLPRFWRPPYGDTDTRVHAIAQEVFGLTTIMWNHDTEDWSLTEPDGTTPSAVHAELAAWYGGPKSPGLIVLEHELSNLSVQAYVDAFPLIAQNGWALVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K0U1</accession>
    <name>A0A2H3K0U1_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Carbohydrate-binding module family 13 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_139259</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468168">
        <property type="protein sequence ID" value="PCH44799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K0U1"/>
    <dbReference type="OrthoDB" id="3228793at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23422">
        <property type="entry name" value="beta-trefoil_Ricin_MPL_CNL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH44799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="231" mass="25925" checksum="11D2321E0DB00F2B" modified="2018-01-31" version="1">MQPQDAAPLRSSLAHSIFYLQNVQSGTAMDLADKPNGQYNVKGHPLHMERNQQWKFIPLGKGYAIQSMWPNANGPLYLTVRSLADRAQVVTTHYPVTWDIEHICLWEDTNTIRIVWPTTRFAIELDDGGSLKPGTRVQLKTIDPNGHQCQLWKFMRCDPQSVQSIPSQPKPIVFEPSQSITQPLVSESVLTTEDQYVITTTRTITTITRTLRNCSDTDPLAQSSGGSSCEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K0U3</accession>
    <name>A0A2H3K0U3_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Spo11/DNA topoisomerase VI subunit A N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_90460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
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                <person name="Martin R."/>
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                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
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                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
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                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
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</entry>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
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                <person name="Martinez A.T."/>
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                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
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                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
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                <person name="Ling A."/>
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                <person name="Morgenstern I."/>
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                <person name="Nagy L.G."/>
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                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
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                <person name="Eastwood D.C."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7 8">MD-104</strain>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
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                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
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                <person name="Spatafora J.W."/>
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                <person name="Benoit I."/>
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                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
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                <person name="Igarashi K."/>
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                <person name="Kallen N."/>
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                <person name="Kuo A."/>
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                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
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                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
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                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
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                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="28"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH43324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="413" mass="46197" checksum="D689440674ED9183" modified="2018-01-31" version="1">MSNDQQRSSPSQHRLVHYKPLSDGNCPIERMPNAILACIFGFVLCHPVYDWCIGRVMVVCRRWNDIAMHTPQLWTDIAVDEARRASDISLYLERSARLPIYIYVKNGTQTTFENLVRCSSRIKELYCFFNKSSDLSCLGALHDPAPVLESLSIHFDNYSTDATDAPRDVAANPAIPSTIFNHQAPNLRKLTLNPFVPTLGCNLTHLRLECQNGTTWNMNRFMTLLQANPSLEELHMFDASPAPVSQFSGFVDLPKLRVWSLGCHDCTELSRILQCVGIPSTAQLIISDLEEAGSSISDSFPQDISKLRNLGVLTDVHITVESGMIKVLALPTNGTAALRFTTCGSLSYFVHTSQNIGKILSVAHLTHLSISTGVDSAFWFRPTQRELDEARDASLWEAMFSQVAPRKLRHMET</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K4I3</accession>
    <name>A0A2H3K4I3_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WOLCODRAFT_106064</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KB468168">
        <property type="protein sequence ID" value="PCH45078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K4I3"/>
    <dbReference type="STRING" id="742152.A0A2H3K4I3"/>
    <dbReference type="OMA" id="VEACHAM"/>
    <dbReference type="OrthoDB" id="541276at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895">
        <property type="entry name" value="CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895:SF32">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="14"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="346"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="355"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PCH45078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="423" mass="46551" checksum="40E8FC5803271024" modified="2018-01-31" version="1">MPDFRGSIIHGGRYKLVELLGSGAFGVVYRAIDMHVPPFAGRVHMQRAIKIIRKAGPLKSDTARQRQEISLHSLVSKHPNILSLYDAFEYKDFYFLVMEFVPGGDLYTRIVDGQEFHGNDELVRSVFVQILDAVEACHAMNVYHRDLKPENILCSTTCRKVYLADFGLATTRAVSGTFGCGSSHYMSPECINESGQFDCYSTAQNDIWALGVILVNLVTGCNPWQAARNDDLCYEEFLTTEAHFYDRDNLSDGVAELLHKIFDLNAHARPTIPEMRRTIMGLRSFWKKPVKTAAPIEAFEAEIEEVPRVKLPKGTEAVDELTHALRVANLGDADVEEVDLGTLSTISYDEHKMPSGSSSASTSTSGDDSAGPATPDKNADEPHVSTADFASELDKALLPLATPAKDTIDTQHVSALLGRLGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K542</accession>
    <name>A0A2H3K542_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HAD hydrolase IA REG-2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_144563</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468146">
        <property type="protein sequence ID" value="PCH43537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K542"/>
    <dbReference type="STRING" id="742152.A0A2H3K542"/>
    <dbReference type="OMA" id="WWRQLIA"/>
    <dbReference type="OrthoDB" id="444127at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16415">
        <property type="entry name" value="HAD_dREG-2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.720">
        <property type="entry name" value="Haloacid dehalogenase-like hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051828">
        <property type="entry name" value="HAD-like_hydrolase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011949">
        <property type="entry name" value="HAD-SF_hydro_IA_REG-2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044924">
        <property type="entry name" value="HAD-SF_hydro_IA_REG-2-like_cap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02252">
        <property type="entry name" value="DREG-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46191">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46191:SF2">
        <property type="entry name" value="HALOACID DEHALOGENASE-LIKE HYDROLASE DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013749524" evidence="1">
        <location>
            <begin position="17"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH43537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="247" mass="27346" checksum="CC32799BA09C826B" modified="2018-01-31" version="1">MAIRLVIFDALQTLIAFRLPVYVQYAQTFEPHLGPLDPDAIKKSFKTALKQLQVEQPAYQSGAEGWWGEVIRRTAVGAGADHNAVGSSLPELTRRLLHRFSSREGYRAFDDALPTLQRLREAGIRTGVVSNADARMHTVLVDLGLASYLDEILLSDEERMEKPAREIFLRACARIGVRPNEALHVGDELQADYHGACGSGLSALLVRRPGPDGMDENKEPDEDLTGVQTVPGLAHVVEWVRQREAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K577</accession>
    <name>A0A2H3K577_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WOLCODRAFT_154237</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD-104</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468157">
        <property type="protein sequence ID" value="PCH44204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K577"/>
    <dbReference type="STRING" id="742152.A0A2H3K577"/>
    <dbReference type="OMA" id="YPERWVE"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF187">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="371"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PCH44204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="406" mass="44793" checksum="ED3E52CC8EBEBECA" modified="2018-01-31" version="1">MYGIFVCLSPNHISIVHPVALPAVYGHSSGALKAPFYDAFASFKTRNMFNTISRTGHTRKRRIESQIFSQQSVRELEGTTRVHHIDLVSQWDKLYSYVKRAESDGVREGFNYWSFDIIGDLAFGDPFGMILAAKDTARSAKSVNASLATFSTSSNTKKFAFEMEELPVTEIIGQRGELITMLGWLPKYVRPIILMMPGFRSNLQAIPKVAGSAVTAVAKRMNDLDAHADMLNRLLDARDENGEPMSPEELSSEASLIIVAGAITVANTSCAITYYLARDQRVQAKLQAELDDALKADDSIVAPHDAIKHLPYLDAVVNEGLRLDSPAPGSAYLRGENASEFYPERWVEASGDQKKAMLDAFVPFSIGPRACIGCNLASMQLHTVLATLFHRFNVVLESDDPVRSQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K663</accession>
    <name>A0A2H3K663_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AAA ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WOLCODRAFT_26851</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468157">
        <property type="protein sequence ID" value="PCH44554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K663"/>
    <dbReference type="STRING" id="742152.A0A2H3K663"/>
    <dbReference type="OMA" id="VWPAYPE"/>
    <dbReference type="OrthoDB" id="27435at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034098">
        <property type="term" value="C:VCP-NPL4-UFD1 AAA ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097352">
        <property type="term" value="P:autophagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051228">
        <property type="term" value="P:mitotic spindle disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071630">
        <property type="term" value="P:nuclear protein quality control by the ubiquitin-proteasome system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030970">
        <property type="term" value="P:retrograde protein transport, ER to cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19519">
        <property type="entry name" value="RecA-like_CDC48_r1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19528">
        <property type="entry name" value="RecA-like_CDC48_r2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000004">
        <property type="entry name" value="Cell division control 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.330.10:FF:000001">
        <property type="entry name" value="Cell division control 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000003">
        <property type="entry name" value="Transitional endoplasmic reticulum ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000012">
        <property type="entry name" value="Transitional endoplasmic reticulum ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000048">
        <property type="entry name" value="Transitional endoplasmic reticulum ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.20.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
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</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K698</accession>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
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                <person name="Copeland A."/>
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                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
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                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
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                <person name="Kumar T.K.A."/>
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                <person name="Ling A."/>
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                <person name="Morin E."/>
                <person name="Murat C."/>
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                <person name="Ohm R.A."/>
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                <person name="Sun S."/>
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            <strain evidence="1 2">MD-104</strain>
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        </source>
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        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
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</entry>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
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                <person name="Lindquist E."/>
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        <source>
            <strain evidence="9 10">MD-104</strain>
        </source>
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            <text>ATP + H2O = ADP + phosphate + H(+)</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="term" value="C:cytosol"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="DEAD_box_RNA_helicase"/>
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        <property type="entry name" value="Helicase_C-like"/>
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        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBPA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        </location>
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        <source>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PCH45074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="506" mass="56374" checksum="A69B0181CE912FEB" modified="2018-01-31" version="1">MCNQIDFLHAFRSQDSRKIVMEKFREGSIKILCTTEAAGMGLDIADITRIVQFMVPPSLSVWVQRYGHVVRSGGAGIAVLLVEPSVYKIKGKKTTVPGGAQDLVVEHNEGGRVSEYGSPKSSEYGDLETTNAESDTSTSSQDGSSVSESGVSSDESEFDCEDNEESESPHTCTHGAEVNELRTSDEPTKKTVTYAKMVESGMRRWIETEICRRKVANIYFANPLSEVELTVPCCDVCLFNKEHSEAASLSASEQAMLTKLKCIQKCILGYALDVAMVGAEAEHIEESSGKTKRPRAPWRMGDRRGPRLKGCKQALKKWRSQAWRTHYQHSSWDEDTLLPDTVLNKLSSKARLQTIEEVRIEVPKWVFTEKHWEDVRSVLKSLDGAHWSRVDVASGEKAAKHRKISEENRMRRDEERLAAKRATTARHRQAQAQAPIPDWQLQWEAWEAWQAHAAAQSAAPWIDSADSMASSSAYIQHTGTVTMPSHLQTDGDQPPAMPGLLPEPGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K7Q9</accession>
    <name>A0A2H3K7Q9_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_154510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468157">
        <property type="protein sequence ID" value="PCH44467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K7Q9"/>
    <dbReference type="STRING" id="742152.A0A2H3K7Q9"/>
    <dbReference type="OMA" id="HANEANG"/>
    <dbReference type="OrthoDB" id="3208495at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="608"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="647"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="616"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="647"/>
            <end position="660"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH44467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="667" mass="76143" checksum="AD763D5F730BD171" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K7U0</accession>
    <name>A0A2H3K7U0_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Peptidyl-prolyl isomerase CWC27</fullName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Peptidyl-prolyl isomerase cwc27</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14 15">Rotamase CWC27</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">WOLCODRAFT_133278</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the cyclophilin-type PPIase family. CWC27 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="KB468157">
        <property type="protein sequence ID" value="PCH44507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K7U0"/>
    <dbReference type="STRING" id="742152.A0A2H3K7U0"/>
    <dbReference type="OMA" id="DDWYDVY"/>
    <dbReference type="OrthoDB" id="442970at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01925">
        <property type="entry name" value="cyclophilin_CeCYP16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000007">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase CWC27 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF6">
        <property type="entry name" value="SPLICEOSOME-ASSOCIATED PROTEIN CWC27 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0697">Rotamase</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="17">
        <location>
            <begin position="12"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="177"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="241"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="177"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="303"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="347"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="387"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="405"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="426"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="18">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00055615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00067721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00071024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00082698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00083804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PCH44507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="475" mass="53498" checksum="1D663EB87CA163B4" modified="2018-01-31" version="1" fragment="single">MALPTKGRVIVDTTAGEIDIELWSKETPKACRNFLSLAMEGYYDGVIFHRIVPGFLVQTGDRTGTGAGGESFYGEPFEDEIHPRLRFAHRGLVAMANNGTKNSNDSQFFITLDRADELHGKHTLFGRVIGDTLYNVLKIGEMEIDANERPIYPPKIKTIRIVDNPFEDIVPRITAEEKRAQQRAKERAQREREEEQRRRGAKKDVKLLSFGADEGAEEEEPISFKKKPIVRPDLLEPEKPIAVPDFISAPSKDKAKSQSRAEPSEVKAAQRQTSEKAAKKEDSEITKIREKHAQEQAAQSNGRKTEIEKMEAEIRRLARRGGEESDDEPARKKVKKSYLEEEMAKYTKGRGVHKKGKRRDEGDVLAALNSFRSKIKSTAPDMDEAQAPSVGAEGGEAPPEGQPAGEEDPGMEVDDDTDFLAHALHFPKDNDEEVAKAERDYEVIDPRQRGARAKEEERERKRAVKAKDGRRGYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K9I5</accession>
    <name>A0A2H3K9I5_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SET domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WOLCODRAFT_77714</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468168">
        <property type="protein sequence ID" value="PCH45077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K9I5"/>
    <dbReference type="STRING" id="742152.A0A2H3K9I5"/>
    <dbReference type="OMA" id="CSHRERF"/>
    <dbReference type="OrthoDB" id="265717at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050869">
        <property type="entry name" value="H3K4_H4K5_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197:SF251">
        <property type="entry name" value="EG:BACR7C10.4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SET" evidence="6">
        <location>
            <begin position="64"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="MYND-type" evidence="7">
        <location>
            <begin position="109"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="24"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PCH45077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="590" mass="64019" checksum="5BC503C1319CD281" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IT45</accession>
    <name>A0A2H3IT45_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA mismatch repair protein MSH3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3 9">DNA mismatch repair protein MSH3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WOLCODRAFT_93032</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD-104</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Heterodimer consisting of MSH2-MSH3 (MutS beta). Forms a ternary complex with MutL alpha (MLH1-PMS1).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH33162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3IT45"/>
    <dbReference type="STRING" id="742152.A0A2H3IT45"/>
    <dbReference type="OMA" id="KMTMLYK"/>
    <dbReference type="OrthoDB" id="276261at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000870">
        <property type="entry name" value="MutS protein homolog 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011184">
        <property type="entry name" value="DNA_mismatch_repair_Msh2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007861">
        <property type="entry name" value="DNA_mismatch_repair_MutS_clamp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF21">
        <property type="entry name" value="MUTS PROTEIN HOMOLOG 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05190">
        <property type="entry name" value="MutS_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005813">
        <property type="entry name" value="MSH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53150">
        <property type="entry name" value="DNA repair protein MutS, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0469">Meiosis</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="11">
        <location>
            <begin position="662"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="23"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00073774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PCH33162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="839" mass="92498" checksum="4EE784CC5C815A55" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IXH7</accession>
    <name>A0A2H3IXH7_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transcription factor TFIIIC triple barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_139519</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467832">
        <property type="protein sequence ID" value="PCH34682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3IXH7"/>
    <dbReference type="STRING" id="742152.A0A2H3IXH7"/>
    <dbReference type="OMA" id="QMDHVMG"/>
    <dbReference type="OrthoDB" id="1877767at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042771">
        <property type="entry name" value="GTF3C6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019481">
        <property type="entry name" value="TFIIIC_triple_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21860:SF2">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21860">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIIC TFIIIC , POLYPEPTIDE 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10419">
        <property type="entry name" value="TFIIIC_sub6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor TFIIIC triple barrel" evidence="2">
        <location>
            <begin position="29"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH34682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="265" mass="28304" checksum="A5AEFFF1357F6C6D" modified="2018-01-31" version="1">MSATLVPGYQLVDAFGVDDDYEQHDGEVEEEVSYVTLDLGTVEPTLVPSSSSYRLIGLDSPTPFLQIAGTIFKGQHQRLLGTELLFTDSDDGQADHGKRLLHPVGITEQRIKFKEVELKEKGSQSPPDAQQVSSNKGKSTRDRIPETVDEVTGNVSAERYAPEVRSTGRGRGGRSAKGKSKGKGKEREDDAGDDEEAPVTTRSRKKNVKHATAPPGNEGVDDAGDQPEMSEDPRASGIGEGSADVSGVTTRDGRAPMGVDVSLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IYE5</accession>
    <name>A0A2H3IYE5_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyltransferase family 20 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WOLCODRAFT_27576</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the trehalose phosphatase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the glycosyltransferase 20 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467843">
        <property type="protein sequence ID" value="PCH35002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3IYE5"/>
    <dbReference type="STRING" id="742152.A0A2H3IYE5"/>
    <dbReference type="OMA" id="VHPMPIE"/>
    <dbReference type="OrthoDB" id="755951at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005946">
        <property type="term" value="C:alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003825">
        <property type="term" value="F:alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004805">
        <property type="term" value="F:trehalose-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03788">
        <property type="entry name" value="GT20_TPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01627">
        <property type="entry name" value="HAD_TPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000036">
        <property type="entry name" value="Alpha,alpha-trehalose-phosphate synthase subunit Tps2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1020:FF:000002">
        <property type="entry name" value="Trehalose-6-phosphate synthase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1020">
        <property type="entry name" value="Trehalose-6-phosphate phosphatase related protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001830">
        <property type="entry name" value="Glyco_trans_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003337">
        <property type="entry name" value="Trehalose_PPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00685">
        <property type="entry name" value="T6PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788">
        <property type="entry name" value="TREHALOSE-6-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788:SF123">
        <property type="entry name" value="TREHALOSE-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00982">
        <property type="entry name" value="Glyco_transf_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02358">
        <property type="entry name" value="Trehalose_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="61"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="85"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PCH35002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="923" mass="102181" checksum="E6ACC62E2D359434" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IZL6</accession>
    <name>A0A2H3IZL6_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_166269</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
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                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
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                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
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                <person name="St John F."/>
                <person name="Stenlid J."/>
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                <person name="Sun S."/>
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                <person name="Pisabarro A."/>
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                <person name="Grigoriev I.V."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH35922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="138" mass="14960" checksum="401B31FA7149C0DE" modified="2018-01-31" version="1">MEVADVEVMEVMEVAEVVEVVEVTEVADAKVAEVMEFAEVVTDYSVAPHRQVVGVADVEVVEVAEVAEVMEVTEVTEVTEVAEVMEVMEIAEVAEVTEVAEVTEVVEVMEVMEVAEVVEVMEVTEVAEVTDVEVMGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J1A8</accession>
    <name>A0A2H3J1A8_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_93757</name>
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    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Phaeolaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
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                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH33573.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
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    <sequence length="167" mass="18230" checksum="906D69F75442DF2D" modified="2018-01-31" version="1">MSAPEDPPYYILVSHDSPPSIPSAAPSTSLSHPTIEYHYADDSPHSLLPRYPGEQIIVLDYDPTKGPTPTIKSLSKDLAVTGLRIADAPGAGVTAEDPRNNKMYILEAMTLPEETRDEEDHQSPHTILARFRQRNAILRSALEYPGSLQNGQQPTETTLQDPTSAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J1H5</accession>
    <name>A0A2H3J1H5_WOLCO</name>
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        <submittedName>
            <fullName evidence="11">Root hair defective 3 GTP-binding protein</fullName>
        </submittedName>
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        <name evidence="8" type="primary">SEY1</name>
        <name evidence="11" type="ORF">WOLCODRAFT_28353</name>
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        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
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            <taxon>Phaeolaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
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                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
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                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
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                <person name="St John F."/>
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                <person name="Sun H."/>
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                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD-104</strain>
        </source>
    </reference>
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        <subcellularLocation>
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            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <text evidence="8">Enriched in the cortical ER. Concentrated in punctae along the ER tubules.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. RHD3 subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="PCH36110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="742152.A0A2H3J1H5"/>
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    <dbReference type="OrthoDB" id="1597724at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="P:endoplasmic reticulum membrane fusion"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="GBP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Protein SEY1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03109">
        <property type="entry name" value="Sey1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="G_GB1_RHD3_dom"/>
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    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008803">
        <property type="entry name" value="RHD3/Sey1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046758">
        <property type="entry name" value="Sey1/RHD3-like_3HB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45923">
        <property type="entry name" value="PROTEIN SEY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45923:SF2">
        <property type="entry name" value="PROTEIN SEY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05879">
        <property type="entry name" value="RHD3_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20428">
        <property type="entry name" value="Sey1_3HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51715">
        <property type="entry name" value="G_GB1_RHD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="topological domain" description="Cytoplasmic" evidence="8">
        <location>
            <begin position="1"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="676"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="8">
        <location>
            <begin position="695"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="702"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="8">
        <location>
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            <end position="775"/>
        </location>
    </feature>
    <feature type="domain" description="GB1/RHD3-type G" evidence="10">
        <location>
            <begin position="44"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="54"/>
            <end position="61"/>
        </location>
        <ligand>
            <name>GTP</name>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PCH36110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="775" mass="88622" checksum="F9B47A15117A2868" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J2E7</accession>
    <name>A0A2H3J2E7_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_20526</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">MD-104</strain>
        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="301" mass="31617" checksum="2DE4814909EA013A" modified="2018-01-31" version="1">MDDMLPTPLRRRHTRANPSIADLRSIQRSVSCAAPPALALDTPGASGSNVRITTRIVSTMRRSLSVAPRRRDTSPPGGAMYSTPAESTPPLPPRFDTADAPLPTVQQIAMGLHVSRTPHLRSPRASPLQLTDDSAPLATLQLRTRAPTPRRRASTSTPALPPPPARSSLKKPRPPTPAHSPTPPRSAPLTPTASDLSLTGSTLTCGAPPPVRGRGTSVAVPFIPGRLQLSMPRFLRVPSGRKAQAQVDSGAVDAGAARKVVRFSTVSSAGSLPDLHAPPGGADKLRESLDVVPLSPPRHSS</sequence>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
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                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
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                <person name="Lundell T."/>
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                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
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                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
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                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1221748"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">MD-104</strain>
        </source>
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            <end position="95"/>
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            <end position="342"/>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="405" mass="42613" checksum="1C6634FD54D754F2" modified="2018-01-31" version="1">MATPEPSQKSPANLSAATIAQSATYALLSYVMYTWALRWVAIGPLYGTGTRIATTLGLNKPLPATTVAPSRIPDFLLRLVLIPLLTIPLFLGFGLDKSADTDTGTDTASDTDSDDASGSPSASIDDYQSEIYDNSSLPWDWASQDPAVRCWLYPVDTSGWFGSPSDGVSEGEDGGVYIDVADKHAGNASADGLWNQPNEDDANSYAWHGTAGGESEDDDALFGLEDTLFAMDDPDVPSPLPSSEPNPELDPDVSYWLNPPPDPAAWTLPPSSSPSQIAPKPADESANVTENADFTGCGTELSDTNEDGDASGRGDGSRSGSESGDETACSSRSRSESPASSETDVGSLDGSGEENEPVGKKLRWNGWWTDPAACFMWPEDANPNVSPQGDSHASPVDGEGVGFEV</sequence>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
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                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </evidence>
    <sequence length="225" mass="25139" checksum="92DACC8CC4E4DCBB" modified="2018-01-31" version="1">MFIQTETTPNEDSLKFIPGVPVMEEGTAEFLDTKSALKSPLAIRLMGIEGVKTVFYGPDFVTVSKDSETAWAVVKPEVYSILMEFFSSSQPLFRSEEDREAAGPQDTRILDTDSETVAMIKELLETRVRPAIMEDGGDIEYRGFTDGGVVQVKLKGSCRGCDSSTVTLKSGIERMLMHYIPEVKGVEQVLDQEEEIALNEFQKLEQRLHPENSKKDSPIAQYMSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J3C4</accession>
    <name>A0A2H3J3C4_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Mitochondrial carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WOLCODRAFT_141564</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH33239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J3C4"/>
    <dbReference type="STRING" id="742152.A0A2H3J3C4"/>
    <dbReference type="OMA" id="FPFWKAV"/>
    <dbReference type="OrthoDB" id="448427at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050391">
        <property type="entry name" value="Mito_Metabolite_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45618">
        <property type="entry name" value="MITOCHONDRIAL DICARBOXYLATE CARRIER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="3"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="98"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="204"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PCH33239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="295" mass="32154" checksum="9D07EED2A7E1C5EF" modified="2018-01-31" version="1">MPKKQTYPFWLGGVAGSMAASCTHPLDLTKVRMQTVPSLPGANRPSTYSVIRTTVADHGVRSLYTGLTASLLRQMTYSLVRLGSYEGMKDRLSKDGSPSSGKLLVAAMLAGGMGGVAGNPADVLLVRMTSDSIRPPEKRYNYSNALTGLVTLVRSEGVKGLFRGVGTNIVRAVLMNGSQVWSYDLFKSTLLRNRIPIVDFQFKDNLALHMVASTVAGTVATTVCSPADVLRSRLMSASGKTNPLEVLKKSLREEGPRFLFKGWTPAFIRLGPNTIFMFVFLEQLKKGWRTVFPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J3Q5</accession>
    <name>A0A2H3J3Q5_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">THIF-type NAD/FAD binding fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_140616</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467898">
        <property type="protein sequence ID" value="PCH36872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J3Q5"/>
    <dbReference type="STRING" id="742152.A0A2H3J3Q5"/>
    <dbReference type="OMA" id="ISYTMYD"/>
    <dbReference type="OrthoDB" id="10265862at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061503">
        <property type="term" value="F:tRNA threonylcarbamoyladenosine dehydratase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008641">
        <property type="term" value="F:ubiquitin-like modifier activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061504">
        <property type="term" value="P:cyclic threonylcarbamoyladenosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00755">
        <property type="entry name" value="YgdL_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43267">
        <property type="entry name" value="TRNA THREONYLCARBAMOYLADENOSINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43267:SF2">
        <property type="entry name" value="TRNA THREONYLCARBAMOYLADENOSINE DEHYDRATASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="1">
        <location>
            <begin position="2"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH36872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="367" mass="41011" checksum="2E34EF36BBD28DB4" modified="2018-01-31" version="1">MAKIRKGTVVVVGCGGVGSWAAIMLVRSGISRIRLVDFDYVTLSSLNRHATAVLADVGTPKVKCIERTLKQISRWVEIDARVDIWRKEQGSDLLQGADWVIDAIDNITTKVDLLKYCHDHNIKVFSSMGAGAKCDPTRVQISDISYTMYDPLARSVRRRLRLQGVTSGIPVVYSTEPPSDVKLLPLAEGEFQKGDVKELGVFDDFRVRILPVLGPLPSIFGLHIATFILCELAGKPIPNPLPVKGRKKLNERLYKDLLHREEKLTGQTINKLPIDEDDVGFIFDDISRGRSVVPPHAVPSRPVVARWDLAVPLVLENCVSFEYAEAERHVRECYEGGKRPEDVWGAEVAAVIARRADEIRKAREWVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J4P2</accession>
    <name>A0A2H3J4P2_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_140538</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NUCLEIC ACID-BINDING PROTEIN"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="181"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
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        <location>
            <begin position="58"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="100"/>
        </location>
    </feature>
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        <location>
            <begin position="111"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="133"/>
        </location>
    </feature>
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        <location>
            <begin position="146"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH36635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="333" mass="39996" checksum="55E587837EBF0815" modified="2018-01-31" version="1">MSSKADEYSKRGRSRSRERGPRDERRDRSREAYSRRSRSREQGREKERQRRGGGDRRRGSHSHSRSRSPPRRHRHSRSRSRSHSRTRDDRKSKRDHDGRRGRYSSSRSRSPRGDKERRRDRSRERRKHSRSRSRSVSSSASDSSDRRRHKRKKEKKSRKHEDKKKDKKDKKKKINAASHQWGKYGIINESDLFTKEQEFRAWLVEERKINPETISKEQTKREFARFVEDYNTATLPHEKFYHMEAYERRMNALRAGEFVPPPDDAYDPDADLRALQSSHRRRAIERETYMSKEQLQELRKVQNERIEAGKMKLLGMDIKQNMGVRMDGSMFDG</sequence>
</entry>
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    <accession>A0A2H3J4W0</accession>
    <name>A0A2H3J4W0_WOLCO</name>
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        <submittedName>
            <fullName evidence="8">GroES-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WOLCODRAFT_147862</name>
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    <organism evidence="8 9">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycetes</taxon>
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            <taxon>Phaeolaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD-104</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
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    <comment type="similarity">
        <text evidence="5">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
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    <dbReference type="InterPro" id="IPR011032">
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    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813:SF1">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G03930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="7">
        <location>
            <begin position="56"/>
            <end position="185"/>
        </location>
    </feature>
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        <location>
            <begin position="226"/>
            <end position="291"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
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                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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        <location>
            <begin position="1"/>
            <end position="215"/>
        </location>
    </feature>
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        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="139"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH37340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="215" mass="22056" checksum="B58D041D92C07C63" modified="2018-01-31" version="1">MQARGVPAPPRAPSLQTTAHGGADRLTNRALGLDDPQQHPAPHAYPQGRTNVRGIASAPAPVSAGQPLRSHTGNARSGVKHNQKGPDKDGKDAKAPKATGHPSPYAHPAGPLRQRQGHPGQQSRTSGRPYGKGNRPSHTTQPQATATSPPAYQTQERATAHSRQGNPPRTKSNSGAAALPNAPPLPPTASTPGCAAGTPQGSEVARGADTLKTPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J604</accession>
    <name>A0A2H3J604_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_29753</name>
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    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J604"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH37371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="55" mass="6042" checksum="7D9348A2DD148E1D" modified="2018-01-31" version="1">MHIKVAHAKPGKQREHLKTQLQGTGTKVTRDCAKTIHLVPSGSPILYDRLCPLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J6I1</accession>
    <name>A0A2H3J6I1_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">WD40 repeat-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_135884</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH37860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="TRANSDUCIN_WD40 REPEAT-LIKE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH37860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="350" mass="37207" checksum="BB1676378A19E661" modified="2018-01-31" version="1">MSLQSSFNLPSAITALTIVDDDGLCVGSEDGCLRLYHLPSPRVVRAVKSIGSEISSIVSHQSKKSETSAIWLASGQRAYSFPSKADKLIIAPEDATASVTLGEDEEDVLNELSISDNGQYLAFSTDGGSAGVIELSTVKVTRMKTRHSNICGSVKFIPGRPSELVSGGYDSALLHYDFAQGRTLSRYDITAAPPSSGISLSPPFILSTAISPTALFAAGTADGRVWLGGGGEKRASSAKKKRSRKWEGLKEDEGVWMQVAEGPIVAVAFCGMSTLYTCTLLGTLARYQISRNEGGNLHSERTWSAEAKAIEKVNAISINEKWLVVGGLDKAGKGVAEVWDVTSLTQIENA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J762</accession>
    <name>A0A2H3J762_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">t-SNARE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WOLCODRAFT_87844</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
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        <property type="protein sequence ID" value="PCH38102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J762"/>
    <dbReference type="STRING" id="742152.A0A2H3J762"/>
    <dbReference type="OMA" id="HPRNAPQ"/>
    <dbReference type="OrthoDB" id="10255013at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15849">
        <property type="entry name" value="SNARE_Sso1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00179">
        <property type="entry name" value="SynN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.70:FF:000008">
        <property type="entry name" value="Syntaxin family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006011">
        <property type="entry name" value="Syntaxin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF307">
        <property type="entry name" value="PROTEIN SSO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00804">
        <property type="entry name" value="Syntaxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00503">
        <property type="entry name" value="SynN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="9">
        <location>
            <begin position="211"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PCH38102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="316" mass="35249" checksum="DD947E9EFB110CC1" modified="2018-01-31" version="1">MARDRLAALRAQTGQDGSQQSHEMSALQSPSVVSPASNGGGYQDSDPMSRFYAEVTSIQDGLAEFSANVSRIGELHSRSLNSTDEAASQQNSAALDDLITRTRTLSNDLKEHIQTLAKYPAPRPQDARVRNNQTGLLRSKFVEILQSYQQVERDYRQRYKQRVERQFRIVKPDATPEEIDAVVNNTSSGGDQIFAQALSNSTRYGESRAAYREVQDRHQDIIRIEQTLEELAQMFNDMSVLVQQQDESINAINTTAGDVEANTKAGLEQTEKAVVHARRARRMRWICFIIVLICLAVVGIVVGVVVSNNVKNSHNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J7X4</accession>
    <name>A0A2H3J7X4_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WOLCODRAFT_135288</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH33738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J7X4"/>
    <dbReference type="STRING" id="742152.A0A2H3J7X4"/>
    <dbReference type="OMA" id="EMWIEYE"/>
    <dbReference type="OrthoDB" id="1926878at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23837">
        <property type="entry name" value="UBCc_UBE2O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000094">
        <property type="entry name" value="Probable ubiquitin-conjugating enzyme E2 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46116">
        <property type="entry name" value="(E3-INDEPENDENT) E2 UBIQUITIN-CONJUGATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46116:SF15">
        <property type="entry name" value="(E3-INDEPENDENT) E2 UBIQUITIN-CONJUGATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="4">
        <location>
            <begin position="674"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="555"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="604"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="560"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PCH33738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="924" mass="102400" checksum="2A4882B40D019E67" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J8N7</accession>
    <name>A0A2H3J8N7_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Enolase C-terminal domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WOLCODRAFT_106973</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD-104</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KB467843">
        <property type="protein sequence ID" value="PCH35099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J8N7"/>
    <dbReference type="STRING" id="742152.A0A2H3J8N7"/>
    <dbReference type="OMA" id="PRWCFLK"/>
    <dbReference type="OrthoDB" id="2579025at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008869">
        <property type="term" value="F:galactonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034194">
        <property type="term" value="P:D-galactonate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03325">
        <property type="entry name" value="D-galactonate_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="D-galactonate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="entry name" value="Enolase-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="entry name" value="Enolase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034593">
        <property type="entry name" value="DgoD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023592">
        <property type="entry name" value="Galactonate_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013341">
        <property type="entry name" value="Mandelate_racemase_N_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010624">
        <property type="entry name" value="PRK14017.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48080:SF2">
        <property type="entry name" value="D-GALACTONATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48080">
        <property type="entry name" value="D-GALACTONATE DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02746">
        <property type="entry name" value="MR_MLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00003">
        <property type="entry name" value="D-galactonate_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00001">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00179">
        <property type="entry name" value="mandelate_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="Enolase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="Enolase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mandelate racemase/muconate lactonizing enzyme C-terminal" evidence="5">
        <location>
            <begin position="126"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PCH35099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="383" mass="42573" checksum="AE074F457C24004C" modified="2018-01-31" version="1">MSTITKIETFRVPPRWLFVRVETADSTVGWGEGTLEGHTEAVEGAYKDLARRFIGWDADRIQDIWQHAYRSRFYRGGPVLMSALSGLDIALWDVKGKRLGVPVWQLLGGKVRDRLKVYGWIGGDKPHAVIEGAKSRKQQGFTAVKMNGTEAIDWIDSPSQLAETVARITDVKSIGLDVGIDFHGRVHKGMAKQLARLLEPLQPLFIEEPLLPTQPQEIADISRLVSTPIALGERLFSRSEFRPYLEARAIDIAQPDVAHCGGISEMHRIASLVETYDVALAPHCPLGPIALAACMQVDISAPNFFIQELSLQMHYNEGADLLTYLVDPTVFAIKEGYVEALQGPGLGIEINEALVREYAERYSSEKPWINAVWTGADGSVREW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J984</accession>
    <name>A0A2H3J984_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WOLCODRAFT_115016</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD-104</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class I-like SAM-binding methyltransferase superfamily. BUD23/WBSCR22 family.</text>
    </comment>
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        <property type="protein sequence ID" value="PCH38185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="742152.A0A2H3J984"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070476">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000017">
        <property type="entry name" value="probable 18S rRNA (Guanine-N(7))-methyltransferase"/>
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    </dbReference>
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        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Bud23_C"/>
    </dbReference>
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        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12734:SF0">
        <property type="entry name" value="18S RRNA (GUANINE-N(7))-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12734">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="5 12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="10">
        <location>
            <begin position="54"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="18S rRNA (guanine(1575)-N(7))-methyltransferase Bud23 C-terminal" evidence="11">
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            <begin position="202"/>
            <end position="280"/>
        </location>
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        <location>
            <begin position="263"/>
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        </location>
    </feature>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
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                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
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                <person name="Lucas S."/>
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                <person name="Martin R."/>
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                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
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                <person name="Stenlid J."/>
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                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
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                <person name="Martin F."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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    </dbReference>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH34298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J9G0</accession>
    <name>A0A2H3J9G0_WOLCO</name>
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        <recommendedName>
            <fullName evidence="4">THO complex subunit 1 transcription elongation factor</fullName>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
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                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
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                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021861">
        <property type="entry name" value="THO_THOC1"/>
    </dbReference>
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        <property type="entry name" value="HPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13265">
        <property type="entry name" value="THO COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11957">
        <property type="entry name" value="efThoc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="537"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="701"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="551"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="574"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="620"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="638"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="701"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="718"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="741"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="759"/>
            <end position="785"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH34308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="785" mass="87655" checksum="B0EC1053D7E4ECAE" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JA45</accession>
    <name>A0A2H3JA45_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphoribosylglycinamide formyltransferase</fullName>
            <ecNumber evidence="2">2.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">5'-phosphoribosylglycinamide transformylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">GAR transformylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WOLCODRAFT_63130</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(1)-(5-phospho-beta-D-ribosyl)glycinamide + (6R)-10-formyltetrahydrofolate = N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide + (6S)-5,6,7,8-tetrahydrofolate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15053"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="ChEBI" id="CHEBI:195366"/>
            <dbReference type="EC" id="2.1.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5-phospho-D-ribosyl)glycinamide (10-formyl THF route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the GART family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.2" evidence="2"/>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH33524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JA45"/>
    <dbReference type="STRING" id="742152.A0A2H3JA45"/>
    <dbReference type="OMA" id="HYVDEGM"/>
    <dbReference type="OrthoDB" id="5575075at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00126"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004644">
        <property type="term" value="F:phosphoribosylglycinamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd08645">
        <property type="entry name" value="FMT_core_GART"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.170:FF:000009">
        <property type="entry name" value="Phosphoribosylglycinamide formyltransferase (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.170">
        <property type="entry name" value="Formyl transferase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004607">
        <property type="entry name" value="GART"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001555">
        <property type="entry name" value="GART_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00639">
        <property type="entry name" value="PurN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43369">
        <property type="entry name" value="PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43369:SF2">
        <property type="entry name" value="PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="Formyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00373">
        <property type="entry name" value="GART"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Formyl transferase N-terminal" evidence="10">
        <location>
            <begin position="10"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PCH33524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="254" mass="27881" checksum="60D89A1B89209078" modified="2018-01-31" version="1">MSEIPSRQRRIVVLISGSGTNLQALIDAQNTSALPNTSISLVLSNRKAAYGLTRAAQATPPIRTAYLAMQPYLKANPGKTRDDYDVEVARIVAREKPDLVVLAGWMHIMGTGFLDVVNGDKALEGEDKEKPIPVINLHPALPGAFDGAHAIERAYEAFQKGEITNSGVMVHRVVKEVDRGEPVLVREVEIKPGEPIEAFEERLHKTEWEIIVQGTAKVLDEVAPSGVRPPFGIRSCALTSTSSHYDMPLRLWLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JAH6</accession>
    <name>A0A2H3JAH6_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WOLCODRAFT_88184</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH38595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JAH6"/>
    <dbReference type="STRING" id="742152.A0A2H3JAH6"/>
    <dbReference type="OMA" id="AAFWQIF"/>
    <dbReference type="OrthoDB" id="2123952at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14725">
        <property type="entry name" value="ZIP_Gal4-like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF29">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH38595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
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            <dbReference type="Proteomes" id="UP000218811"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JAR2</accession>
    <name>A0A2H3JAR2_WOLCO</name>
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        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
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        <name evidence="11" type="ORF">WOLCODRAFT_20189</name>
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    <organism evidence="11 12">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
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                <person name="Sabat G."/>
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                <person name="St John F."/>
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                <person name="Syed K."/>
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                <person name="Wiebenga A."/>
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            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </reaction>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
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        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_ST"/>
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    </dbReference>
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    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
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        <location>
            <begin position="8"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        </location>
    </feature>
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    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PCH35839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="885" mass="96528" checksum="6F663133536CE422" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JB13</accession>
    <name>A0A2H3JB13_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_129232</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycetes</taxon>
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            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467987">
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    <dbReference type="STRING" id="742152.A0A2H3JB13"/>
    <dbReference type="OMA" id="GMIEDWL"/>
    <dbReference type="OrthoDB" id="3981028at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="411"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="277"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="319"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="359"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
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            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
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                <person name="Martinez A.T."/>
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                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
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                <person name="Benoit I."/>
                <person name="Boyd A."/>
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                <person name="Ferreira P."/>
                <person name="Findley K."/>
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                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
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                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
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                <person name="Larrondo L.F."/>
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                <person name="Morgenstern I."/>
                <person name="Morin E."/>
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                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
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        </location>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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</entry>
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            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Martinez A.T."/>
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                <person name="Benoit I."/>
                <person name="Boyd A."/>
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                <person name="Gorecki P."/>
                <person name="Heitman J."/>
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                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
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    <proteinExistence type="predicted"/>
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    <feature type="non-terminal residue" evidence="1">
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            <position position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH39826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="105" mass="11660" checksum="46E85E9D9BD33610" modified="2018-01-31" version="1" fragment="single">MALAEDTIQQAHPGPAMDILHLYLPRAPRCRSLLSYGSGNCSFRDRRASTATDTRKAKTSGTVTAVTWYHGAQRCGLDRTGCNRRRRMCRVYCSPILVICDSIIA</sequence>
</entry>
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            <fullName evidence="3">Phosphodiest-domain-containing protein</fullName>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
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                <person name="Kallen N."/>
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            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
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        </location>
    </feature>
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        </location>
    </feature>
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            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="364" mass="39046" checksum="C3E2669E1A731911" modified="2018-01-31" version="1">MRIIKSSENTNILLTQVVIDLAQTATGMVKNPDGNREISQRVYAQNEVRLSPYARRDRQPLAHLVVIFPPSISGSSAHQPFTILHPPRGTVRLSSGPSISTPGAFASAHPPALAHAPATARTARLLSRAPCFSPGHRASLAVSGRSLAYRRRVPSACPGPGCRCRFRCLRSAAAARQGPASQADCCRQPVCSPARAHAHPASWHGRLHIRGAPIARPDPRAPPRVAHQPPQRRSSSSRVPGVVSWRVTGRRRGGSAGCGPLSASINWPRGRWILGFDRRAHAGLLRFLTREPEARFAPSNPSQSHQARSPSHSAARSVAHADGRTPRISARRIDSPRTRGIDDGRHSSNRSDLSAAEGATTGSG</sequence>
</entry>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
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                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
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                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        </location>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH40306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="400" mass="43509" checksum="465247C4170CBE77" modified="2018-01-31" version="1">MHIKLKPHWYKVVPTGATTPSSTIHHGHGVAPSCVTTTVASGHTAHALGHALTANGHHGAPSQDANSGALPGKVACPWSGASLNRPHRHTSNGRQLRRITMMMARPRERRLPYNPSEHHAHALGNEHPQPTATPAIPNRTPPPACCHVGGVPLERRLPKPSATASALRYTRARPPATTAYPNRSPPPPLRRPRLARMERRLPKPSTTTYLPRTSTPARYLESNGRQLRCVTMTMARPRERRLPTTVHHGSGIALPPSSSRRRPLHTASPWGRVYSLQPTGAAPPTTQNTRPPPPPYNRPQHLRNQPEPPRSTKPEQAAPEEPPPPYLERYGHGGALVHPPKDAKTGDPEQEPRPTKPPALNQPTTATDTQDPSSEGKTTILGVGPIIPRSAPLDKYKDTA</sequence>
</entry>
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                <person name="Kallen N."/>
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                <person name="Martin R."/>
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                <person name="Nagy L.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:NADPH dehydrogenase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02932">
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    </dbReference>
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        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Aldolase_TIM"/>
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        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
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        <property type="entry name" value="YqjM-like"/>
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    </dbReference>
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        </location>
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    </evidence>
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    </evidence>
    <sequence length="415" mass="44942" checksum="6E39B3F61D01A2FD" modified="2018-01-31" version="1">MPNIFNPPAPGIPYYTPAQYPPAGTVVDPQPNGRPIPALFQPVKIRGVEFPNRLWLSPMCQYSAEDGKLTPWHYAHLGGIIQRGPGLSMVESTSVTPEGRITPEDSGLWCDEQIAPLKEIVTFAHSQNQKIGIQLGHAGRKASTVAPWLDQGATAIEAVGGWPNEVYAASAGAYSDSYPKPKELTKEGIKNIVHAFVDAAKRALKAGFDVIEIHNAHGYLLHGFVSPASNKRTDEYGGSFENRTRLTIEIVDAVRAMIPPDMPLFLRISATDWLEESLADEPSWTPQDTVRFAGILADHGVDLLDVSSGGLHPAQKIKGGPAYQAPFAELVKKEHGDRILVSSVGAISDGKTAQGVLEKGQADAVFVARQFQKNPGTVWQFAEELGVDITVAHQIEWGFMGRGNVGRAHKGPKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JE16</accession>
    <name>A0A2H3JE16_WOLCO</name>
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        <submittedName>
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    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
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                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
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                <person name="Yadav J.S."/>
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                <person name="Benoit I."/>
                <person name="Boyd A."/>
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                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB468053">
        <property type="protein sequence ID" value="PCH40131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="742152.A0A2H3JE16"/>
    <dbReference type="OMA" id="QVCRTVC"/>
    <dbReference type="OrthoDB" id="19141at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:methionyl glutamyl tRNA synthetase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="GST_C_AaRS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02799">
        <property type="entry name" value="tRNA_bind_EMAP-II_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000047">
        <property type="entry name" value="tyrosine--tRNA ligase, cytoplasmic isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Arc1-like_N"/>
    </dbReference>
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        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002547">
        <property type="entry name" value="tRNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051270">
        <property type="entry name" value="Tyrosine-tRNA_ligase_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11586:SF33">
        <property type="entry name" value="AMINOACYL TRNA SYNTHASE COMPLEX-INTERACTING MULTIFUNCTIONAL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11586">
        <property type="entry name" value="TRNA-AMINOACYLATION COFACTOR ARC1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21972">
        <property type="entry name" value="Arc1p_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01588">
        <property type="entry name" value="tRNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50886">
        <property type="entry name" value="TRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 6" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="GST C-terminal" evidence="8">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="TRNA-binding" evidence="9">
        <location>
            <begin position="236"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="146"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="146"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="158"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="176"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="199"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PCH40131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="410" mass="44394" checksum="98735DA03AC12541" modified="2018-01-31" version="1">MASAAAISKLPNPLRDFVTTATSDPEQDFGTTEKDKAEVAEWIEQIAQGDVTKPENLKDLDTKLVPRTYLVNNYYTAADAALCGALHPVFSQLQPAQYYTYPALTRYFDHIQWQPQVRTAALFAEPEGAFSQVAFDLDSAPKIERKADHPKEKKKAPAADPSAAAPVKSKKKEEAPAAAETSEEVSTGEAKAQKKEKKEKKEKEKKPVEAAEAGKKKAAGGGGKQAAADEGSGEPVPSMIDLRVGHIIDIKKHPDADGLYVEQIDFGEETGPRTVVSGLVHYIPIEEMRDKYLVGVCNLKPANMRGVKSFAMVLCATSKDGKESGIELVQPPAGSKPGERVYFEGADFENATPLSQLNPKKKIFETVQPGFTTLETKEAAWVNPTTKSVHRIRTKDGVCVAPTLTGASLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JEA4</accession>
    <name>A0A2H3JEA4_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WOLCODRAFT_130303</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="PCH34297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="742152.A0A2H3JEA4"/>
    <dbReference type="OMA" id="AREPHDI"/>
    <dbReference type="OrthoDB" id="413582at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007346">
        <property type="term" value="P:regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF508">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="10"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="188"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="188"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="284"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PCH34297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="452" mass="49906" checksum="2AD9FD435DCC12F7" modified="2018-01-31" version="1">MNKVIGFADPESMKLIEESPVAYITRAHLLEETDGTNFTPRTWVAIKSASILPKLSKQPHDIGKELRILHSAKHVNIIETMGHTFDLDTETLHVWMPYIPYTLCNLLDSPAFSPHPCAPTSSSPSPASTHSASFAILARSLVYQLTAALAHLHARHIAHRDIKPRNVLLTLSGCVKLIDFGAAWVPPAPRSPPPTSSRPSSPPPSLSSHEPTLTQRPYDLWPEPSGAMCTAVASGPYRAPELLFGPRDYDAYATDLWALGATCAEFCTPLQLTSKKDVERGWDEGEDEDGEEDGDIPGEQKLQRPFIVPPTVSLDDPGTKWHRLPLFDASREEIGLAWSIFKIRGTPTAETWPGFNSLPDACKITFMTVPPIDITRLLPNVPQEWPEIVDLVNALLAYPPEQRLHAETALRHPHLVGGTLLLPERYPLSEGVFTWENKTLGELLATHLDALC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JEN9</accession>
    <name>A0A2H3JEN9_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_162293</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000218811">
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    </dbReference>
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        <location>
            <begin position="253"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH40351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="298" mass="32304" checksum="EAF4D3F7599DFDE9" modified="2018-01-31" version="1">MIARRFTPYNADLAGGPFAREFSCTASFVRKPEGKLADPAHSVVDISREEAHIIVSDGATSATQNGPRTTPAPSLSFPVSRCQRRKRAQKTCTVSRQQLHRHLASIRHRHPHGAVRTAPAPAHALGREIAFWALEDGAVLLARVSLASRAPLTYAECLVARRAPAFHSLYHSFYARPHPDLGKLAHAARSPSPARVRSSRTAPCYALHLASDVEGTKSLGARIISVALATTGALNFPPPVATLYNTREHLHSRASLRAARHHRTHADGRPGAESNRSITHHASDPFGLRPRAHAASAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JER9</accession>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="1" type="ORF">WOLCODRAFT_24211</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH40696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JER9"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH40696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="192" mass="20432" checksum="DF587D3D76060CD8" modified="2018-01-31" version="1">MSPIARPPVELRRYGPTEAAQQSARGDILRRCVTGFGSKALVARQQCSVDGSASPTASFDSIIIVIHACEEVTLMSATSCHHGAAPARKICCAHLRDSSPPVHGYICGVVCHNFEGNSGKNLNPVSSYYISRPKSALINSTSFCRSFVDHAVVEPDNTKVCSAVQEGCASLARRNLGCIACGAVLLDRLRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JEV2</accession>
    <name>A0A2H3JEV2_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Non-ribosomal peptide synthetase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_130834</name>
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    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH38333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JEV2"/>
    <dbReference type="STRING" id="742152.A0A2H3JEV2"/>
    <dbReference type="OMA" id="TWIVLPW"/>
    <dbReference type="OrthoDB" id="3142841at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052979">
        <property type="entry name" value="Adenylate-forming_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33927">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33927:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="274"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH38333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="499" mass="56992" checksum="DD5BA719E608F67A" modified="2018-01-31" version="1">MSSELTPRVPAPAYDSDAEKGALDLQVRSVPPVEVALHDEKQDLIKAQVLTVPAPEKKEAAPPAYTKPPKYKVSKWILWQLWYNTYRKLFTISFSVNIILFGFAVSGHWPYAIKYGGAMAVGNFNVSVLLRNEIFGRFLYLFVNTCFAKWSPLKWRLACTSVLQHLGGIHTGCAIAGVIWLTLRVVDVFVHHAEYNNSVLVFGVLVNVAMVVTMFAGFPWVRNTHHNVFERWHRFMGWTGLFLSWIFILMGDLYDTDTRRWNVSGYHVVHQQDFWYVIGMTVWIVLPWICTRRVLIDIELPSNKVAVLRFERGMQQGLLGRISRSAVKEYHAFGIISEGPHAKYHYMVCGVQGDFTRSLVNDPPRTIWTRELKLAGVSNTSKLYKRGIRICTGTGIGAALATCIQSPYWYLIWIGSDQYKTFGPTISGLITRNIEPERYLLWDSKVRGGRPDTRKILREVYHSWKAEVVFITSNYVGNSEMMQACKAEGIPCFGTLWDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JFZ9</accession>
    <name>A0A2H3JFZ9_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WOLCODRAFT_64378</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD-104</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH38763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JFZ9"/>
    <dbReference type="STRING" id="742152.A0A2H3JFZ9"/>
    <dbReference type="OMA" id="ANYSERR"/>
    <dbReference type="OrthoDB" id="2802867at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF2">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ALNH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PCH38763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="110" mass="12562" checksum="CB9EA278747BB540" modified="2018-01-31" version="1">MTLTTQLGIAISVLALWYILRRRDTAIKRALPFPPGPPPKPLIGNVLQIPIDYQQFVFTEWAHTYGDLIYLRIINKPLLVLSSAKAAFDLMDKRSAIYSDRPHATIWEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JG64</accession>
    <name>A0A2H3JG64_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcription activator of gluconeogenesis ERT1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WOLCODRAFT_145598</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467843">
        <property type="protein sequence ID" value="PCH34997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JG64"/>
    <dbReference type="STRING" id="742152.A0A2H3JG64"/>
    <dbReference type="OMA" id="PGMVYAY"/>
    <dbReference type="OrthoDB" id="5575144at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050335">
        <property type="entry name" value="ERT1_acuK_gluconeogen_tf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47659:SF7">
        <property type="entry name" value="FUNGAL TRANSCRIPTIONAL REGULATORY PROTEIN, N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47659">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="114"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="151"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="271"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="151"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="305"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="331"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PCH34997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="361" mass="38486" checksum="712549A3FB9E29E6" modified="2018-01-31" version="1">MATEQPKSTNTGGQEHPPPHPVVPYPPPGQYASHYPPTAPYPPFYYAPIPEGHDPNAVPPPGPYIVAIPPPPPGMMYAYPAHPPGQGYQPYPPVLAAPPPPNPARPKRKQVKMACTNCASACKRCDEARPCERCVKYGIADSCVDGVRKERKKGIKRGPYKRKNRTQSGEPAAGYPATANGETESAAPPVPYTAPPPPESYYPYYYPHGYPPAPHDGQPHHEGANGQHPHAPYYPMPPMYAPYPPYPGAPPVQMPYPPPAIAAAPANSVAASNGKAEQPAAASEANGDSAGVSPNKTKKRARTTKGNERDDGGAKTKKTKHLPVDSQTDGDAARGKDHHLGSQPETGPVFNNIESRTMVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JGC9</accession>
    <name>A0A2H3JGC9_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_140064</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467854">
        <property type="protein sequence ID" value="PCH35764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JGC9"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH35764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="203" mass="22183" checksum="3796CE45C869A373" modified="2018-01-31" version="1">MCSDAASRVQSRCTLVRTSCVLVPRSVLPPSVYVMADLDFSGRWSEMLSPSLLTRSGIHVQSAVMAHTGKCAWTSLACIKGWTRRKMCSSIVIVSTRLKALPLLPFERVTPLLHECAIGSTIDALRSTAARRPSSSHLPASDRDSHSSRCSCSPCVPPVPSIKSAAMSWLALSTHPVGLTDHPIWLLLHHRSPRRLIRPSRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JGH9</accession>
    <name>A0A2H3JGH9_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PAP-associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_141020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467943">
        <property type="protein sequence ID" value="PCH38953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JGH9"/>
    <dbReference type="STRING" id="742152.A0A2H3JGH9"/>
    <dbReference type="OrthoDB" id="2274644at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271">
        <property type="entry name" value="POLY A POLYMERASE CID PAP -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271:SF40">
        <property type="entry name" value="POLY(A) RNA POLYMERASE GLD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH38953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="345" mass="39662" checksum="B08A60C075B3FCFB" modified="2018-01-31" version="1">MIVVIKRWASNSRLNDPAGRETGRVSFSSYTLVVMTIGLLQMRGLLPNLQHDLYKVPRNRFDSYMFWAYSSQANKQRGGDAVKVLCDLRFRHGDDFEPKSIPPLRDALIDWFRYWADAHDYSQVLSIRHGGLITKRKLVRDMAYMLPRPPQTVFVNAREQVHLERLLSDEFEKSEEADYEDFGLAKAPRRVRSAAADNAVARAAMDEDDNDDRLLAALDYEDTKRKTTPPKEAAGPDADFDPIAHIGLDIKERWKHARLCVGDPFIRHKNLASPIAHYILDDFQKKCREAATFLEEGGPIDWLLKSKSELKSMNRRERNSSSHTQRQPRSRHRMDPELSPEATAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JGX5</accession>
    <name>A0A2H3JGX5_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HIG1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_137390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH41440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JGX5"/>
    <dbReference type="OMA" id="LGHYTWP"/>
    <dbReference type="OrthoDB" id="3356019at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH41440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="129" mass="14134" checksum="B85B217FF735A8CF" modified="2018-01-31" version="1">MDRATRNEDVQRAYEIQANAAVAGAARFSAVGTGLAILGHYTWPAFRRQTLPFKCFLVSISTVFGLVIGAENALMAHEAERRQTETALRKEARIDLARRGLVATETEIAKWRAARIAEQQAQSGEGTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JGX8</accession>
    <name>A0A2H3JGX8_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="10">PPIase</shortName>
            <ecNumber evidence="10">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">WOLCODRAFT_88834</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 10">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the cyclophilin-type PPIase family. PPIL4 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="10"/>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH40795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JGX8"/>
    <dbReference type="STRING" id="742152.A0A2H3JGX8"/>
    <dbReference type="OMA" id="APKCCEN"/>
    <dbReference type="OrthoDB" id="2083at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01921">
        <property type="entry name" value="cyclophilin_RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12235">
        <property type="entry name" value="RRM_PPIL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000015">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035542">
        <property type="entry name" value="CRIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035538">
        <property type="entry name" value="Cyclophilin_PPIL4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45843">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-LIKE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45843:SF1">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-LIKE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="12">
        <location>
            <begin position="6"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="13">
        <location>
            <begin position="246"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="188"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="332"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="201"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="361"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="389"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="418"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PCH40795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="449" mass="51042" checksum="B7EB7E53C574A871" modified="2018-01-31" version="1">MSVLLETSLGDIVIDLEVELCPKTCQNFLKLCKVYYYNLNAFFNVSKDFLAQTGDPSATGTGGESIWSFIASQQGKQEPRYFSPEFVPRLKHKAKGTVSMAVAPAIDGQGSGGCGSQFFVTLADEIDYLDGKHAVFGHVVEGLDTLDKLNEVFVDQDGRPLKDVRIRHIEILDDPFDDPEGLVVPDAIPTRPPDNSTRIAEDEDPLATLPEEEAEAERRKQAARASALTLEMVGDLPFANVRPPENVLFVCKLNPVTRDEDLELIFSRFGPIMSCQVIRDKKTGDSLQYAFIEFDKREDAEQAYFKMQNVLVDERRIWVDFSQSVARLNTSWSNDPKVGPRMARGGKRRASGGYGGVDNLEATRRFREGSAGDDSGYGMVFDVPGDRYPRRRSRGRSRSRTPPRDDSMERRRRSRSPRPRDYRTREHDRERRGSRSRDRRSRDRYERRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JHI9</accession>
    <name>A0A2H3JHI9_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Protein disulfide-isomerase</fullName>
            <ecNumber evidence="5 14">5.3.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">WOLCODRAFT_137140</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Participates in the folding of proteins containing disulfide bonds, may be involved in glycosylation, prolyl hydroxylation and triglyceride transfer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Catalyzes the rearrangement of -S-S- bonds in proteins.</text>
            <dbReference type="EC" id="5.3.4.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.4.1" evidence="5 14"/>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH41025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JHI9"/>
    <dbReference type="STRING" id="742152.A0A2H3JHI9"/>
    <dbReference type="OMA" id="FFGMKKD"/>
    <dbReference type="OrthoDB" id="427280at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02961">
        <property type="entry name" value="PDI_a_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02982">
        <property type="entry name" value="PDI_b'_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02981">
        <property type="entry name" value="PDI_b_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000139">
        <property type="entry name" value="Protein disulfide-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000017">
        <property type="entry name" value="Protein disulfide-isomerase A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005788">
        <property type="entry name" value="PDI_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005792">
        <property type="entry name" value="Prot_disulphide_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01130">
        <property type="entry name" value="ER_PDI_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01126">
        <property type="entry name" value="pdi_dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929">
        <property type="entry name" value="PROTEIN DISULFIDE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929:SF132">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13848">
        <property type="entry name" value="Thioredoxin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 14 17" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11 12" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013432373" description="Protein disulfide-isomerase" evidence="14">
        <location>
            <begin position="26"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="16">
        <location>
            <begin position="7"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="16">
        <location>
            <begin position="350"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="477"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="12">
        <location>
            <begin position="54"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="12">
        <location>
            <begin position="392"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605792-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PCH41025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="501" mass="56156" checksum="B871198283AC3C00" modified="2018-01-31" version="1">MRFSHFFSSATVLALVAAVAADAASDVINLTSDNFDAVVNPSSLILVEFFAPWCGHCKALAPHYEEAATALKEKDVKLAKVDCVDQADLCQANGIQGYPTLRVYRHGDYTDYTGPRKADGIISYMTKQSLPAVTDVTPANFEEFTKADRIVAVAFLTSPANAPGPEFIMTANKHRDDYLFGASADPAVADAAGITPPAIVLYRSFDEPTTEYPYPVGSAKSQDIEAWIKELSIPIIDEVNTENYQTYAQSGKPLAYLFVDPTDARREEYLSALQPVASKWKHNLNFVWIDAIRFGDHAKALNLNEPKWPSFVIQDIRKQLKYPYDQSQEVTAEEVDKMVAQYVDGKLQPQLKSQPVPETQDESVFNLVSKQFEDVVFDDDKDVFVEFYASWCGHCKRLKPTWDSLGDRYADVKDRIVIAKMEAQENDLPPSVPFRVAGFPTLKFKQAGSREFIDYNGDRSLESLVAFVEENARNPLDPKIPFRTKNDTQAQPETHEHHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JHP3</accession>
    <name>A0A2H3JHP3_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DUF323-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WOLCODRAFT_119486</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD-104</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; ergothioneine biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH41710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JHP3"/>
    <dbReference type="STRING" id="742152.A0A2H3JHP3"/>
    <dbReference type="OMA" id="EHDGFHI"/>
    <dbReference type="OrthoDB" id="659at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1580.10">
        <property type="entry name" value="paralog of FGE (formylglycine-generating enzyme)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024775">
        <property type="entry name" value="DinB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051128">
        <property type="entry name" value="EgtD_Methyltrsf_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005532">
        <property type="entry name" value="SUMF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042095">
        <property type="entry name" value="SUMF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43397">
        <property type="entry name" value="ERGOTHIONEINE BIOSYNTHESIS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43397:SF1">
        <property type="entry name" value="ERGOTHIONEINE BIOSYNTHESIS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12867">
        <property type="entry name" value="DinB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03781">
        <property type="entry name" value="FGE-sulfatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DinB-like" evidence="5">
        <location>
            <begin position="5"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase-modifying factor enzyme-like" evidence="4">
        <location>
            <begin position="205"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase-modifying factor enzyme-like" evidence="4">
        <location>
            <begin position="318"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PCH41710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="422" mass="47187" checksum="A682D3766F1C9DD2" modified="2018-01-31" version="1">MGMIPTTLLHSKPIDLRHKPLFYIGHLPTFLNILLTKYLGESPVAPVAYTRIFERGIDPHVDDPTYCHSHSEVPEKDEDWPTIAEVLAYRDRVREKLASVYREVEAGTRKMTRRLARTLVMVLEHDGFHIETLLYILIQRAGTGMLPPPGFAMPPWAALAAQWDAVSPPCTPTVTLGPATLTFGHDDPEPSDLLPELANDTEDHEFGWDNESPARAVQVGRFRIDWRPVTNGEFLAFWRGAGKGTVDMPASWVLDGSAEDGEVRVRTLYGPVPMDVARHWPVLTAYDDLVAYAKAKGGRIPTEPELRLFLDTYQVGYEEGANAGFRNWHPLPATAGGEEDGGRGSNGGVWEWTATLLDTHEGFEGTTIFPGYSSDFFDTKHQVVLGASYATIPRLGDRRTVRNFYQHNYPYPWVGARVAYDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JHP4</accession>
    <name>A0A2H3JHP4_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Phosphoribosylaminoimidazole carboxylase</fullName>
            <ecNumber evidence="4 11">4.1.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">WOLCODRAFT_137546</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + H(+) = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + CO2</text>
            <dbReference type="Rhea" id="RHEA:10792"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:77657"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="EC" id="4.1.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (carboxylase route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">In the C-terminal section; belongs to the AIR carboxylase family. Class I subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.21" evidence="4 11"/>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH41702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JHP4"/>
    <dbReference type="STRING" id="742152.A0A2H3JHP4"/>
    <dbReference type="OMA" id="PANVKWK"/>
    <dbReference type="OrthoDB" id="15425at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004638">
        <property type="term" value="F:phosphoribosylaminoimidazole carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1970:FF:000013">
        <property type="entry name" value="Phosphoribosylaminoimidazole carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000037">
        <property type="entry name" value="Phosphoribosylaminoimidazole carboxylase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01929">
        <property type="entry name" value="PurE_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01928">
        <property type="entry name" value="PurK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016301">
        <property type="entry name" value="Ade2_fungi/plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003135">
        <property type="entry name" value="ATP-grasp_carboxylate-amine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033747">
        <property type="entry name" value="PurE_ClassI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000031">
        <property type="entry name" value="PurE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005875">
        <property type="entry name" value="PurK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040686">
        <property type="entry name" value="PurK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054350">
        <property type="entry name" value="PurT/PurK_preATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004679">
        <property type="entry name" value="PRK06019.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01162">
        <property type="entry name" value="purE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01161">
        <property type="entry name" value="purK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11609:SF5">
        <property type="entry name" value="PHOSPHORIBOSYLAMINOIMIDAZOLE CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11609">
        <property type="entry name" value="PURINE BIOSYNTHESIS PROTEIN 6/7, PUR6/7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00731">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02222">
        <property type="entry name" value="ATP-grasp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17769">
        <property type="entry name" value="PurK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22660">
        <property type="entry name" value="RS_preATP-grasp-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001340">
        <property type="entry name" value="AIR_carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01001">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52255">
        <property type="entry name" value="N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="10 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="13">
        <location>
            <begin position="113"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR001340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PCH41702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="579" mass="61867" checksum="D966D988C230085F" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JHU9</accession>
    <name>A0A2H3JHU9_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WOLCODRAFT_99902</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5 6">MD-104</strain>
        </source>
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        <location>
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            <end position="245"/>
        </location>
    </feature>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="PCH41135.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="260" mass="29899" checksum="28564C17ED4B03D1" modified="2018-01-31" version="1">MENGTGVDKPHAKVVIVTNLTRNVVEAHLRTIFGFYGEIIKIDLPVFGKSRQNRGKAALEYVDSTSAHRAQSHMDGGQLDGAILKVELSELPVRSRSRSPRPPPRPRYGRDRPRSLSRTPSRSRSPPRRFARGGRFGDSYRGRPLGRRGPPPRDTYRPLSRSRSRSPVRRGDRLPPRRRSPSYERGGTGFRRRSRSRSYSVRSSRSRTRSLTPRSRTRSLSYSSYSRYSRSRSRTRSLSRGRRSHSRDDIRDSRSRSPRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JIH5</accession>
    <name>A0A2H3JIH5_WOLCO</name>
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        <submittedName>
            <fullName evidence="11">GMC oxidoreductase</fullName>
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        <name evidence="11" type="ORF">WOLCODRAFT_28614</name>
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        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
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        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
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                <person name="Lundell T."/>
                <person name="Martin R."/>
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                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
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                <person name="Stenlid J."/>
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                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
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                <person name="Martin F."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD-104</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="PANTHER" id="PTHR11552">
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    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013924420" evidence="9">
        <location>
            <begin position="19"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="10">
        <location>
            <begin position="325"/>
            <end position="339"/>
        </location>
    </feature>
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        <location>
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            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
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            <end position="667"/>
        </location>
    </feature>
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        <location>
            <position position="575"/>
        </location>
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        <location>
            <position position="618"/>
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            <position position="132"/>
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        <location>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PCH36474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="698" mass="74268" checksum="2D927B39727C821C" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JIV4</accession>
    <name>A0A2H3JIV4_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">4-hydroxy-3-methoxy-5-polyprenylbenzoate decarboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">COQ4</name>
        <name evidence="8" type="ORF">WOLCODRAFT_25148</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Lyase that catalyzes the C1-decarboxylation of 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoic acid into 2-methoxy-6-(all-trans-polyprenyl)phenol during ubiquinone biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoate + H(+) = a 2-methoxy-6-(all-trans-polyprenyl)phenol + CO2</text>
            <dbReference type="Rhea" id="RHEA:81179"/>
            <dbReference type="Rhea" id="RHEA-COMP:9551"/>
            <dbReference type="Rhea" id="RHEA-COMP:10931"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:62731"/>
            <dbReference type="ChEBI" id="CHEBI:84443"/>
            <dbReference type="EC" id="4.1.1.130"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion inner membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
            <orientation evidence="7">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the COQ4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468124">
        <property type="protein sequence ID" value="PCH42130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JIV4"/>
    <dbReference type="STRING" id="742152.A0A2H3JIV4"/>
    <dbReference type="OMA" id="YYERHFH"/>
    <dbReference type="OrthoDB" id="4249at2759"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120539">
        <property type="term" value="F:4-hydroxy-3-methoxy-5-polyprenylbenzoate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03111">
        <property type="entry name" value="Coq4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007715">
        <property type="entry name" value="Coq4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027540">
        <property type="entry name" value="Coq4_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12922">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12922:SF7">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS PROTEIN COQ4 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05019">
        <property type="entry name" value="Coq4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2 7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0830">Ubiquinone</keyword>
    <keyword evidence="1 7" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00081568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PCH42130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="268" mass="30359" checksum="50EF9A86A28C6FE1" modified="2018-01-31" version="1">MCLRTVQTRFASTQPAYEGHIPLNWFETGFLTVGSAIMSLVDPRRGDMVAALGDVTSGPVLPRLRDIMLKSPEGRKILKERPRVNSQTVDTNHLALLPEGTFGRAYVTWLERCGVTPDTREPVHYVDDPELAYVLQRYRECHDFYHCVCGLPVNVESELALKFFEFANLGLPVAGVAAAFGHLRLSHEKRARLFREFVPWAVRCGSSARSLISVYWEERWSQDVGEMKKEFGIWDPPEARWSKPLSEAKAAAAKRQREAEAQLAKRSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JJ04</accession>
    <name>A0A2H3JJ04_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Exportin-T</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Exportin(tRNA)</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">tRNA exportin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WOLCODRAFT_137738</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
        <text evidence="9">Shuttles between the nucleus and the cytoplasm.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the exportin family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468124">
        <property type="protein sequence ID" value="PCH42166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JJ04"/>
    <dbReference type="STRING" id="742152.A0A2H3JJ04"/>
    <dbReference type="OMA" id="HEMFLFG"/>
    <dbReference type="OrthoDB" id="26399at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016363">
        <property type="term" value="C:nuclear matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071528">
        <property type="term" value="P:tRNA re-export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045546">
        <property type="entry name" value="Exportin-T_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040017">
        <property type="entry name" value="XPOT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15952:SF11">
        <property type="entry name" value="EXPORTIN-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15952">
        <property type="entry name" value="EXPORTIN-T/LOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19282">
        <property type="entry name" value="Exportin-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <keyword evidence="6 9" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Exportin-1/Importin-beta-like" evidence="10">
        <location>
            <begin position="113"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="Exportin-T C-terminal" evidence="11">
        <location>
            <begin position="373"/>
            <end position="1061"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF19282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PCH42166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="1065" mass="119279" checksum="46F771EDAFFC7CA5" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JJE9</accession>
    <name>A0A2H3JJE9_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WOLCODRAFT_127686</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD-104</strain>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="58"/>
            <end position="87"/>
        </location>
    </feature>
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        </location>
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        <location>
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            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="215"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="480" mass="52704" checksum="A4A87C35E24F01A0" modified="2018-01-31" version="1">MSSYSNDPAHADNTPPPDSASTDSGLQHHFDRTASGEQEIDGPGKKKKGPKRRKVNHACLYCRRSHMTCDDGRPCQRCIKREIGHLCHDERRTSAKEKTPVASTSTVPNPPVDVARVLPAGPTQYGTPTIAPAMNTGWPSMGMSMAQNAFLYQPDALNEFSVLSDFLESLDDGSFFSQPSGVAPSLMSPTPYTGNSVSLAVDNPYIASPQPSGTADAAPAPAPGAAAPEKPAEEPAPVVLPAATKTEKFFLTAADQASGSRNERLNMVIRSKYEAGLLKPYNYVKGYARLSRWMDRNVSLESKQKILQPLSVLRPKFRAIAQSESLTDIDLVFIEEAFERLLLDYDRVFSAMAIPACLWRRTGEIYKANREFAELVGVDGFMLRDGRMCIYELMAEDSAVNYWEKYGNVAFDSNQKAVLTSCVLRYKPLLPSSGSMTPARGKSKQTPPKEEGFISCCFSFTIRRDPYGIPTLIVGNFIKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JKA8</accession>
    <name>A0A2H3JKA8_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal protein L24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WOLCODRAFT_115001</name>
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    <organism evidence="6 7">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL24 family.</text>
    </comment>
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        <property type="protein sequence ID" value="PCH38178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="60S ribosomal protein L26"/>
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        <property type="entry name" value="Rib_uL2_dom2"/>
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        <property type="entry name" value="Ribosomal_uL24_CS"/>
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        <property type="entry name" value="Ribosomal_uL24_euk/arc"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_uL24_KOW"/>
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        <property type="entry name" value="rplX_A_E"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="60S RIBOSOMAL PROTEIN L26 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_L26"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RIBOSOMAL_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="KOW" evidence="5">
        <location>
            <begin position="48"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PCH38178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="136" mass="15562" checksum="B2D5ABF3BF7A2FE8" modified="2018-01-31" version="1">MKFNPDVSSSRRKSRKAHFSAPSSVRRIIMSSALSKELRGKYNCRSLPIRKDDEVRIVRGKYKGREGKVTQVYRKKWVIHVDRVSRDKSNGATANIGIHPSNVVITTIKLDKDRRAILERKGQKKDKAIEDAKMAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JKN7</accession>
    <name>A0A2H3JKN7_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WOLCODRAFT_130817</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
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</entry>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Heitman J."/>
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                <person name="Kallen N."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">MD-104</strain>
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        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
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</entry>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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    </feature>
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        <source>
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        </source>
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        </source>
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</entry>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
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                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
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                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
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                <person name="Martin F."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
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        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="202"/>
        </location>
    </feature>
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        <source>
            <dbReference type="EMBL" id="PCH38798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="202" mass="22701" checksum="B0E1AD003B6F80E5" modified="2018-01-31" version="1" fragment="single">WESGVEEYSGLSLEDVKKALGLPDGQFPCFNSKEDPLGHDPWTPEGLEALKADTALPLNPRWHQYIGVLKMMRCAINGDPVLLMDKVGVGKTMQAVMFIALRVYYREYFTQHGKFPGMFGKFDQQAVKSDAAEIFDLQNPYRPVLKNHRRNVKDSTIYGHTFGAAFFDEIHAARTVSRLFVSFAEVRSSCQAGFMVGMTVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JMD5</accession>
    <name>A0A2H3JMD5_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_153093</name>
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    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
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        <lineage>
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            <taxon>Phaeolaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
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                <person name="Eastwood D.C."/>
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            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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            <end position="34"/>
        </location>
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            <end position="30"/>
        </location>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH43041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="321" mass="33821" checksum="6B351E043743B540" modified="2018-01-31" version="1">MGFDDPMLRVSQRIDDSEAASPSPSTSNSLPGIHEEDVDIVPHSLRYKDAFSTLPTVQAMTGRPTISSDDNSVPTSGSVLLSPSNTECCIVGKHICSQADLGTTQTLNDTVNIMRDGNRREEDSNNDSIEAVINGASPAVVNSSIAISKAHFTDKHMPMSMLSIGTRDGMDDTSEGNGFDAHDNLGQSSPLVASTSHHACAVSSPGNANARITSCLASTFPTLVAHDAGTCSSPDTMMDDDDLANGQDTAQLATSSVSGPVQPAPVLPIRGNTGSRITTEAELRPSDTVFACLYEDCRFEGMSHQHLHLDVLGHTGVEAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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        <lineage>
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            <taxon>Agaricomycetes</taxon>
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            <taxon>Phaeolaceae</taxon>
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
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                <person name="St John F."/>
                <person name="Stenlid J."/>
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                <person name="Syed K."/>
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                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
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        <location>
            <begin position="19"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH43231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="547" mass="58711" checksum="6E65E48FDE542566" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JN64</accession>
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        </alternativeName>
    </protein>
    <gene>
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        <lineage>
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            <taxon>Basidiomycota</taxon>
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            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
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                <person name="Pisabarro A."/>
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                <person name="Martin F."/>
                <person name="Cullen D."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 23">
            <text>a CDP-1,2-diacyl-sn-glycerol + L-serine = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16913"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="17">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 18">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.8" evidence="5"/>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH38084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="742152.A0A2H3JN64"/>
    <dbReference type="OMA" id="HGCGMIS"/>
    <dbReference type="OrthoDB" id="448573at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003882">
        <property type="term" value="F:CDP-diacylglycerol-serine O-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006659">
        <property type="term" value="P:phosphatidylserine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050324">
        <property type="entry name" value="CDP-alcohol_PTase-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004533">
        <property type="entry name" value="CDP-diaglyc--ser_O-PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00473">
        <property type="entry name" value="pssA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269:SF61">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--SERINE O-PHOSPHATIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="15" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 18 21" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="21"/>
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    </feature>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00032361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00060701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="PCH38084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="242" mass="26138" checksum="BFABAE4366A86293" modified="2018-01-31" version="1">MSQRKIQKETSNGNGSSGEGKDAALQQYRDTEGHFSLVRNFRLADLVTIANGICASFSIFMSAKYLVTNDEDYLWSALAFPYAGLMFDFLDGKVARWRNETSMLGQELDSLADLISFGVAPALLAFVVGLQTYLDTVVLTGFICCGLARLARFNATVAVVPKDAKGKAKYFEGLPIPSSLALVSVLTYWTRMGWIEGKGGIPGGTITLWGAKGGDGDVHLVSFVFAAWAAAMVSKTLRVPKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JN80</accession>
    <name>A0A2H3JN80_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">PIG-F-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WOLCODRAFT_109909</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD-104</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB467931">
        <property type="protein sequence ID" value="PCH37457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JN80"/>
    <dbReference type="STRING" id="742152.A0A2H3JN80"/>
    <dbReference type="OMA" id="WWGGWIR"/>
    <dbReference type="OrthoDB" id="17366at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009580">
        <property type="entry name" value="GPI_biosynthesis_protein_Pig-F"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06699">
        <property type="entry name" value="PIG-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="191"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PCH37457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="321" mass="35018" checksum="728D1FC84AC1EFD8" modified="2018-01-31" version="1">MARRKAVSSSDTSPHETNISQSSKSTRADRVDAGTGKLVAFPFARYISAAGVHTCLLVFIAFFLPRTSLSSLISSQSHDPAEQTTSSNMLTQNPTRTVLWMCGGTMVLQAWWGGWLRTWSLEQRSHARSEKDSSEVTKHKLERNTLERQRIEAFRKAAVTTAAASVAFYILIVLFGAPIASYPLQTYSLGLLLALLTIWTPAYALGALSFGSSTDVLVLRMTWIRLFAELRPRTPIERAMVYPAVGAAIGCWSGAIPIGLDWERPWQAWPLTSAFGAISGYILGSLAALLVSGVAHLAQTDILSSPLLSKAKKQTKKSNES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JN82</accession>
    <name>A0A2H3JN82_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Chitin synthase</fullName>
            <ecNumber evidence="5">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WOLCODRAFT_146882</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 5">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the chitin synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="5"/>
    <dbReference type="EMBL" id="KB467965">
        <property type="protein sequence ID" value="PCH39198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JN82"/>
    <dbReference type="STRING" id="742152.A0A2H3JN82"/>
    <dbReference type="OrthoDB" id="26569at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF38">
        <property type="entry name" value="CHITIN SYNTHASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01644">
        <property type="entry name" value="Chitin_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="672"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="706"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="736"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="231"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU366040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PCH39198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="866" mass="96764" checksum="E2823C10B883EAD1" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JNA0</accession>
    <name>A0A2H3JNA0_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Condensation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_109944</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
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                <person name="Ferreira P."/>
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        </source>
    </evidence>
    <sequence length="80" mass="8926" checksum="65F1B9783F0C6564" modified="2018-01-31" version="1">MAPEYMAKMLEGNPWDGEDTAQGSTASHRENEPIEEGKTLDPASESAEETQVDGDVDDSWEDELIEEVKGQSKIRDWSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JQ58</accession>
    <name>A0A2H3JQ58_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_149928</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468053">
        <property type="protein sequence ID" value="PCH39878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JQ58"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH39878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="134" mass="15725" checksum="3CCE579CFFA89CC8" modified="2018-01-31" version="1">MEERIGDYFHQVVGLQHQAWEHIAKRKDLKKPTHDDDDDDDFDNKDSDSAPVNKRMPNLPPLENLAPRPSPRTRSGYVGQEFPAYNGEFDILRMREIRNVPPKWKIPQVSDKRRETFTPIPTARDLPTYSQSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JQF1</accession>
    <name>A0A2H3JQF1_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_104088</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468146">
        <property type="protein sequence ID" value="PCH43745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JQF1"/>
    <dbReference type="STRING" id="742152.A0A2H3JQF1"/>
    <dbReference type="OMA" id="SICADAM"/>
    <dbReference type="OrthoDB" id="2734547at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH43745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="418" mass="46963" checksum="70E6F4B31734B352" modified="2018-01-31" version="1">MRAQLPSEVWDLIIDYLHNDRKSLDACSLTCRAWLRAARYHRFRHVSLSPKRARGLYRLLYESPGFGHVIKSVELYGRIKLSTAWKDESCLFLAALPALSKLKLSHMTLSGSVLTNITDLRISSLKHISIRRCGLPRPHMLGFIEFIASFRSLESIYIADMSFHATDPMSPIDPPRPPPNVRSLAFGSPMDAPQLLFDWLTASEHRIESFSYQITSGDDVEPLQHMLTTIGPTLTQLNLHIDTDTALDRIFAGHAFTLAPCTALRTCRLALSLPEMCVPANNSLRWVHRILSQLAAPGLAHLALSICADAMDNFGALASECAVHQVSLVPFRDLFALDWVVIGEVMCRPAFESLRQFVLEGRGQPELLDAFVKKRCPEFHARGILEYRVMGEFVGSTVDLSDNELAPMPTTIQLEWDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JQQ1</accession>
    <name>A0A2H3JQQ1_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Clavaminate synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WOLCODRAFT_139027</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468157">
        <property type="protein sequence ID" value="PCH44472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JQQ1"/>
    <dbReference type="STRING" id="742152.A0A2H3JQQ1"/>
    <dbReference type="OMA" id="TYIRNSH"/>
    <dbReference type="OrthoDB" id="406156at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="3">
        <location>
            <begin position="180"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="329"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="347"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PCH44472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="356" mass="38935" checksum="6403A9522281AEB7" modified="2018-01-31" version="1">MPGLTTLPPFPDDVPTHPLLVVDYSLLLAGNEEEIDKLWKAATTLGFWYMKNHGADDDASEMFDMGAETMALPFEEKMKFEQGDDGMSFGYKAPGANATDETGARDNVEFINIAQDDALAWPKSVHRAYPSTVNARMPSTITPFIRKSAEVNRVITEILNTKLGLPAGTLGEKHRLDETSGSEARCIKNPPRPGGISEEKAALGAHTDFGSVTFLHNRLGGLQVMVPGTDKWQYIKPIPGHAVCNLGDAMYIFSGGILKSNLHRVVPPPGAQGYFARWSLAFFTRPGDSVVLRALTDQSPVIAEAVANASDKSMFEGSSTSKEWFARRIKNQRSKNQKGAETWRASRGTEHRPEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JQT7</accession>
    <name>A0A2H3JQT7_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WOLCODRAFT_26681</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD-104</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468157">
        <property type="protein sequence ID" value="PCH44301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JQT7"/>
    <dbReference type="STRING" id="742152.A0A2H3JQT7"/>
    <dbReference type="OMA" id="FMFEGDD"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11063">
        <property type="entry name" value="CYP52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047146">
        <property type="entry name" value="Cyt_P450_E_CYP52_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287:SF1">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="386"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PCH44301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="464" mass="52606" checksum="C5C60AB8E073FF9D" modified="2018-01-31" version="1">MGETRILTSDPNHMKAILATNFQSFEKGDYFRRQMNSVLGTGVFNADGDLWKFHRSLSRPFFSRDRISDFETFGLHADEATLAICARNGSAIDIQDVLFRFTLDSATEFLLGSCVHSLYAVLPPDVDGKRPPISVTAEEFGPALARVQHRLAMRGRTSPLWPLVEFFGDKTKKDMKTIRRFIDPIIEEALRRKKGLKRGVKHVEGTAADEHQTLLDQLIDVTDDAKLIADETLNILLAGRDTTAGTLTFALYFLATHPNVLKRLREEIMIRVGSTRYPDFDDMKEMKYLRAFINETLRLFPAVPGNVRHSAKATVLPPTSTEGKPIYVPANCKVVYFTMSMQRSKDVWGPDAELFDPDRFLDDRVQKYLVSNPFNFIPFNAGPRICLGQQFAYNEMSFFLIRFLQKFDHIELAPDAQPARTLPPASWVTSEGRKAIEQIKPKSSLTMSVTGGLWVRCRESEKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JR50</accession>
    <name>A0A2H3JR50_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sec63-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WOLCODRAFT_137291</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH41279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="742152.A0A2H3JR50"/>
    <dbReference type="OMA" id="MCSATEF"/>
    <dbReference type="OrthoDB" id="5575at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18020">
        <property type="entry name" value="DEXHc_ASCC3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000102">
        <property type="entry name" value="RNA helicase, activating signal cointegrator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000024">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.10:FF:000001">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000062">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.10">
        <property type="entry name" value="Sec63 N-terminal domain-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050474">
        <property type="entry name" value="Hel308_SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004179">
        <property type="entry name" value="Sec63-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057842">
        <property type="entry name" value="WH_MER3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961:SF13">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961">
        <property type="entry name" value="DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02889">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23445">
        <property type="entry name" value="WHD_SNRNP200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00973">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="280"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="507"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="1147"/>
            <end position="1302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PCH41279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="1605" mass="179161" checksum="9ECB7AE8049BA554" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JRU5</accession>
    <name>A0A2H3JRU5_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GPN-loop GTPase 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WOLCODRAFT_77417</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Binds to RNA polymerase II (RNAPII).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468168">
        <property type="protein sequence ID" value="PCH44661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JRU5"/>
    <dbReference type="STRING" id="742152.A0A2H3JRU5"/>
    <dbReference type="OMA" id="ATHNYFL"/>
    <dbReference type="OrthoDB" id="5839at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17871">
        <property type="entry name" value="GPN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000338">
        <property type="entry name" value="GPN-loop GTPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030231">
        <property type="entry name" value="Gpn2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF3">
        <property type="entry name" value="GPN-LOOP GTPASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="XPA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="259"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="266"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PCH44661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="359" mass="38967" checksum="880016E9BDDBAA34" modified="2018-01-31" version="1">MPFGEVVCGAPGSGKSTYCYGKHQLFTALGRPIAVVNLDPANEHIPYPCAVDIAQLITLDDAMAAHGLGPNGAMLFCIEYLEANIDWLEGELARLPPDAYVLFDLPGQVELSTNHESVRRVVRRLARAGFRLAAVHLCDAHYVTDAAKYVSVLMLSLRAMLHLELPHVNVLSKVDLIRQYGDLDFNLDFYTEVQDLSYLETALASASPRYAALNMAICGLIEDFGLVGFETLAVEDKESMLHLMRVIDKATGCVFVPPPTAPAPPGTTADPPADPAGNAHALPPALRPNAHALFSSAAGPIRGPRADPRDVQERWVDAREEWDAWERAQWAREGEAVRAAAAAATKEGAEGAARIRERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JSE2</accession>
    <name>A0A2H3JSE2_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WOLCODRAFT_105790</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468168">
        <property type="protein sequence ID" value="PCH44861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JSE2"/>
    <dbReference type="STRING" id="742152.A0A2H3JSE2"/>
    <dbReference type="OMA" id="PFRLMAV"/>
    <dbReference type="OrthoDB" id="498125at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF121">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PCH44861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="256" mass="27763" checksum="54C4060C138724D9" modified="2018-01-31" version="1">MPALDLPTNSRIAIVTGASQGIGRNIALRLADDGLDVAVNDIPTKSAALKELVVEIRAKGRRALAIEADVSKEDEVAAMVTRVAQELGGLDVMVANAGIMLVKSILETSADELDRTNAINIRGTLLSYKYAAKQMIEQGRGGRIIGEWSFFRILGSPMLAAYSASKFAVRGLTQSAAREFAPYNITVNSFAPGIIKTAMVDHQRNHTRRKLRGKLPAMHLNIAEPEVIASLVSYLVRPESYFITGEQRESGFSLSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JSK3</accession>
    <name>A0A2H3JSK3_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WOLCODRAFT_27147</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB468168">
        <property type="protein sequence ID" value="PCH44921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JSK3"/>
    <dbReference type="STRING" id="742152.A0A2H3JSK3"/>
    <dbReference type="OMA" id="MEKWEAY"/>
    <dbReference type="OrthoDB" id="3241983at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043124">
        <property type="term" value="P:negative regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038753">
        <property type="entry name" value="NFKBIL1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15263">
        <property type="entry name" value="I-KAPPA-B-LIKE PROTEIN IKBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15263:SF1">
        <property type="entry name" value="NF-KAPPA-B INHIBITOR-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PCH44921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="157" mass="18032" checksum="4D51A654217C1028" modified="2018-01-31" version="1">MAWVRAGGVLYDRQGRRDDARTEELRAEIRLQDEEKRVMEQWNAYEDRWRILLATDTPVAFADVPWPLSPAPVTASELTSEAVEKFLFAPLNVRQNTVTKRERIRASLLRWHPDKVSAVLQRVVEGDADAVRNGVNTVFLCLRALQDKDRQLCTSDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JSM0</accession>
    <name>A0A2H3JSM0_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Amidohydrolase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WOLCODRAFT_143210</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD-104</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="PCH40768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="ATZ_TRZ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="5-methylthioadenosine/S-adenosylhomocysteine deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
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        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050287">
        <property type="entry name" value="MTA/SAH_deaminase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43794:SF11">
        <property type="entry name" value="AMIDOHYDROLASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="4">
        <location>
            <begin position="55"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PCH40768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="462" mass="50307" checksum="B023E9534E220CC8" modified="2018-01-31" version="1">MLYVHATIITVNGARDIILDGAILVQGNRIAAIDKTNVLLSECPYEPRVDLTDRIVIPGLINAHMHCAQTLLRGTADDLELVQWLCERIWVLQGNFTPEDGETAARGSIVELLRGGVTCFLESMFSDRYGFDGLCRAVEQSGMRGCLGKIVMDIGTYAQDPKWAMHPGLIEDRETSLGGALQMWEKWDGKANGRIKVWFGARTPGGVSDALYKEMSEISRQKGIPITMHCAEVPADREFFASRSHNPTSYCSSVGLLGPHTVLVHMVHLDDDDVASLEKTGTHVVHCPSSNSKLASGFCRVPALLEAGVNVALGTDGAPCNNTSDLLQEMKLAGIIHKVRTMDPTAVPAETVLEMATINGARAVGLDKEIGSLEVGKKADFVAIDTRKVHLQPWFNPVSAVVYTATAQDVELVVVDGVEVVKNGKVVTMNEAEIWKEVAQKAKEVVRRAGLDEKVKAKWNVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JSR0</accession>
    <name>A0A2H3JSR0_WOLCO</name>
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        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
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            <taxon>Phaeolaceae</taxon>
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    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD-104</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="PCH42933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12316">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12320">
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    </dbReference>
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        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
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        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10352">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
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        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468124">
        <property type="protein sequence ID" value="PCH42179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JTF9"/>
    <dbReference type="OrthoDB" id="187738at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH42179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="135" mass="14770" checksum="903B058F647157B7" modified="2018-01-31" version="1">MCLGAKDTPSDLSMETLRPARGDGQLRVTMEMTNSSSCTSRGSMATHFQLYKRTRQSLGRVANTLTELGMVLDASHQNAGEARENSRPKADELVRPAKEASAYGRRTTGTGWGSVTHLYAQDVCCLHSRPPRNNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JUL5</accession>
    <name>A0A2H3JUL5_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Store-operated calcium entry-associated regulatory factor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Transmembrane protein 66</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">WOLCODRAFT_132447</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SARAF family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468124">
        <property type="protein sequence ID" value="PCH42589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JUL5"/>
    <dbReference type="STRING" id="742152.A0A2H3JUL5"/>
    <dbReference type="OMA" id="WILKGSC"/>
    <dbReference type="OrthoDB" id="20303at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006816">
        <property type="term" value="P:calcium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001256">
        <property type="term" value="P:regulation of store-operated calcium entry"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009567">
        <property type="entry name" value="SARAF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15929">
        <property type="entry name" value="STORE-OPERATED CALCIUM ENTRY-ASSOCIATED REGULATORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15929:SF0">
        <property type="entry name" value="STORE-OPERATED CALCIUM ENTRY-ASSOCIATED REGULATORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06682">
        <property type="entry name" value="SARAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="252"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="256"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PCH42589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="304" mass="33481" checksum="10E526FD41AF36C6" modified="2018-01-31" version="1">MSRTALSRIRALTFYKDSLTKSQRGDPVPQLECVGKPCRLYQPEVVRCTNIGGEGVDVDWKCEADLPESLRFGKVEVSCEGWDGPGDPYVLKGSCALQYRLVQVPDALRRLDEPRFRSRLSGWFDAAYENPSAVIFTIIWLACLLFIAYRFLKSCFSSRSGSASSSLSRPRPSGGGPGSNWFSSNHRLGYSDPPPPYTKYPTSSTSASRAGWRPGFWSGAALGGIGTYLLNRNQRERERARPATAAYDWEQERVFRPSSPSSRPSGWGFGSGRRSGFSSEDRGEGSSNLGSMRRSTGIGGSNVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JUR0</accession>
    <name>A0A2H3JUR0_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 12">Chitin synthase</fullName>
            <ecNumber evidence="2 12">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">WOLCODRAFT_24112</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 12">Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cell membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the chitin synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2 12"/>
    <dbReference type="EMBL" id="KB468053">
        <property type="protein sequence ID" value="PCH40454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JUR0"/>
    <dbReference type="STRING" id="742152.A0A2H3JUR0"/>
    <dbReference type="OMA" id="AWILHYV"/>
    <dbReference type="OrthoDB" id="26569at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013616">
        <property type="entry name" value="Chitin_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF9">
        <property type="entry name" value="CHITIN SYNTHASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01644">
        <property type="entry name" value="Chitin_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08407">
        <property type="entry name" value="Chitin_synth_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 12" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="4 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="580"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="620"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="659"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="688"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="740"/>
            <end position="759"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="870"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="903"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin synthase N-terminal" evidence="14">
        <location>
            <begin position="196"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00024009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU366040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PCH40454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="934" mass="104731" checksum="DE441A8BCBE0101D" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JVH7</accession>
    <name>A0A2H3JVH7_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sugar phosphate phosphatase</fullName>
            <ecNumber evidence="7">3.1.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WOLCODRAFT_164094</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10 11">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate. Its preference for fructose-1-phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>beta-D-fructose 1-phosphate + H2O = D-fructose + phosphate</text>
            <dbReference type="Rhea" id="RHEA:35603"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:37721"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:138881"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>beta-D-fructose 6-phosphate = dihydroxyacetone + D-glyceraldehyde 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:28002"/>
            <dbReference type="ChEBI" id="CHEBI:16016"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="7">
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </cofactor>
    </comment>
    <comment type="domain">
        <text evidence="7">Subfamily III proteins have a conserved RTxK motif about 40-50 residues from the C-terminus; the threonine may be replaced by serine or cysteine.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the damage-control phosphatase family. Sugar phosphate phosphatase III subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.-" evidence="7"/>
    <dbReference type="EMBL" id="KB468135">
        <property type="protein sequence ID" value="PCH42909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="742152.A0A2H3JVH7"/>
    <dbReference type="OMA" id="IFARQKM"/>
    <dbReference type="OrthoDB" id="541375at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097023">
        <property type="term" value="F:fructose 6-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103026">
        <property type="term" value="F:fructose-1-phosphatase activity"/>
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        <property type="project" value="RHEA"/>
    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Protein-glutamate O-methyltransferase C1393.13"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Uncharacterised protein PF01937, DUF89, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036075">
        <property type="entry name" value="ARMT-1-like_metal-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039763">
        <property type="entry name" value="ARMT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002791">
        <property type="entry name" value="ARMT1-like_metal-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12260">
        <property type="entry name" value="DAMAGE-CONTROL PHOSPHATASE ARMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12260:SF6">
        <property type="entry name" value="DAMAGE-CONTROL PHOSPHATASE ARMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ARMT1-like_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111321">
        <property type="entry name" value="AF1104-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Damage-control phosphatase ARMT1-like metal-binding" evidence="9">
        <location>
            <begin position="22"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="329"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="329"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PCH42909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="498" mass="56293" checksum="DE2F17C1D5E42196" modified="2018-01-31" version="1">MYQAPYAPYDFTDKESFAYETVLRRWPVILTNIIDTVYRLNHQLSTSIAKPELYDGDVAETQTKIQEGKNIIETISALKYRMARDRPLEPIPDDGEALTDVYNTELSRLTEQGKGSWFTAPWLYAECYLYRLLRSYFVQTKLWSSFDPFLSQKLDTFRKSSAAIFQLATTMKELEGDKGKLASDPANLNVIFKEMIQMCLWGNATDLSMLTHLTHEDIQHLQSVGRDAQAVRKEFILTDNQDSVWAHLTSLKDARIDFVLDNAGFELFTDFVFADFLVTYTPYVSKVAFHPKLIPWFVSDVTPPDFKSTISSLLSPTFFPSTEPDAQTASLAASAPAQDSSTVPTPSGLPDSRRHLKEMVTRWEGYLRDGVFELSVPLDTPLGASNVKANFWTMPWPYWNMQEQGPEVFDSLKDSGLVIFKGDLNFRKLTGDVKWPAHTPFETAIGPLAGSFPILSLRTNKADVIVGIDKALAEKLDNSGENWRYSGKYAVVLFLPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JW38</accession>
    <name>A0A2H3JW38_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ribonuclease III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WOLCODRAFT_131611</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH40934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JW38"/>
    <dbReference type="STRING" id="742152.A0A2H3JW38"/>
    <dbReference type="OMA" id="MHPAQAI"/>
    <dbReference type="OrthoDB" id="2392202at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
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</entry>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
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                <person name="Martinez A.T."/>
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                <person name="Benoit I."/>
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                <person name="Ferreira P."/>
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                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
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                <person name="Hori C."/>
                <person name="Igarashi K."/>
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                <person name="Kallen N."/>
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                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
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        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
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                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
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                <person name="Spatafora J.W."/>
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                <person name="Benoit I."/>
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                <person name="Heitman J."/>
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                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
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                <person name="Kuo A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="project" value="UniProtKB-SubCell"/>
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    </dbReference>
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    </dbReference>
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            <end position="61"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH44423.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="284" mass="30967" checksum="640081A9FA9382A5" modified="2018-01-31" version="1">MPANAAAENALGTLGTICWTIQLVPQIWKTWRDKSTEGLSMFLVFLWGASAGPMGVYAIVLDLNIPLILQPQLFGALCFFSWAQCMYYGKKRSVAACVAMYFGALVILAAFQAGMVYAIRPSYKRGNGTGAEFFGILSSVIIAVALLPQYWEIYKRREVVGISVLFMTVDMMGGVFSDLSLAFKSSFNIIAGVTYSLVVVMDGLVILLALILNPLTKRRRKRAEAATASSANVVPPSTNDMHEGGPTDIELASNDPPSPSAHADVERKTLNGEKDIEHRQFEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JX14</accession>
    <name>A0A2H3JX14_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein serine/threonine phosphatase 2C</fullName>
        </submittedName>
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    <gene>
        <name evidence="8" type="ORF">WOLCODRAFT_138342</name>
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    <organism evidence="8 9">
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468146">
        <property type="protein sequence ID" value="PCH43439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JX14"/>
    <dbReference type="STRING" id="742152.A0A2H3JX14"/>
    <dbReference type="OMA" id="MCEESDG"/>
    <dbReference type="OrthoDB" id="10264738at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF837">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C-LIKE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="7">
        <location>
            <begin position="31"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="146"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="393"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="179"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="397"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PCH43439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="420" mass="45129" checksum="77B250DC8CDF3734" modified="2018-01-31" version="1">MSPNDTNPDIASAQSSHNGTDMALPAHLSFKCAVTDSKGARRTMEDAHSIVVPFGGVRGQGFFSIFDGHAGKQAADWCGANFATCLLHMLRESPALPIPDVLNQTFHEVDHQLSQLCDESDGKMHSGCTAVTAFLRLEDADGKQTFVPPSFDPLGITQEDAGAAKPEDDEGSVASGSSEESKDGREKEKKGGGNRLKNALKAFGEKRSASPPASPAPAPATPAEVQQQHERERAWTPPEGTNVRRVLYCANAGDARGVLCRGGRALRLTYDHKGSDRQEARRVVEAGGFVMSGRVNGVLNVTRSLGDSSMKEYVVGAPYTTETELTDEDEFLILACDGLWDVVDDQAAVELVRAQPNPTAASEFLLDYALHNYSTDNITVLVVRFRNPPESVVAAENKSQNRTSTDSTIRTGRGLNGTKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JYG1</accession>
    <name>A0A2H3JYG1_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein eS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">RPS1</name>
        <name evidence="8" type="ORF">WOLCODRAFT_24551</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD-104</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="6">Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (25S, 5.8S and 5S).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the eukaryotic ribosomal protein eS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH41187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JYG1"/>
    <dbReference type="STRING" id="742152.A0A2H3JYG1"/>
    <dbReference type="OMA" id="TRFKGHE"/>
    <dbReference type="OrthoDB" id="9834376at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03122">
        <property type="entry name" value="Ribosomal_eS1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001593">
        <property type="entry name" value="Ribosomal_eS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018281">
        <property type="entry name" value="Ribosomal_eS1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027500">
        <property type="entry name" value="Ribosomal_eS1_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11830">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01015">
        <property type="entry name" value="Ribosomal_S3Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01397">
        <property type="entry name" value="Ribosomal_S3Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01191">
        <property type="entry name" value="RIBOSOMAL_S3AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 6 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="initiator methionine" description="Removed" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="modified residue" description="N-acetylalanine; partial" evidence="6">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PCH41187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="256" mass="29370" checksum="F81C8575AD5FF32F" modified="2018-01-31" version="1">MAVGKNKRLSKGKKGIKKKVVDPFTRKDWYDIKAPSIFEKRNVGKTLVNRSSGLKNANDSLKGRIVEVSLADLNNDEEQAFRKIKLRVDEVQGKNCLTNFHGMSFSSDKLRSLVRKWQTLIEAHVDVKTTDGYILRLFAIGFTKRRPQQVRKTTYAQSSQVREIRRKMFEIMTREASSCDLKELVQKFVPEAIGREIEKAARSIYPLQNVYVHKAKILKAPKFDLSKLLELHGESTDETGTRVVKDFKEPEILDSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JYI3</accession>
    <name>A0A2H3JYI3_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_163382</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH41804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JYI3"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="362"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH41804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="383" mass="41577" checksum="ED64E4CEBCA0D09F" modified="2018-01-31" version="1">MSHHPRRPSSPMAQFTVTDRRRYRDSRWMRRTANSGRWGGNHKARRRTVRARRVGRCEHPGGMPAPMASQPQAIGPSTHHHHKTRTDGGEHQAVHATHARPSAPTSPGRPPRERPPTPRSRPDSGHWTAARTDTRGSRAGSARQGPANASRRPLGTDISIAKISQPGRPEPPWGVRVRSRARGKEGRRLSRLEGAGSRVQSDGEVGAPLWVAEQGWTLPACGLVAAAPSARLAQTRQALRGVASRRHCGGCLGHQRTAAKVGQTGARTAHGKGANQLGVWARAQDDRSDGLAPLTTTGTRVQDASRREGRRGRRGVGMVRVPVSAAACNARLEPPWVPAGPESANWRATGASVHHVTDEMDNLREPGRRSAHGTRGRSLRWPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
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    <name>A0A2H3JYW6_WOLCO</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_137337</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH41337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JYW6"/>
    <dbReference type="STRING" id="742152.A0A2H3JYW6"/>
    <dbReference type="OMA" id="MHRLATN"/>
    <dbReference type="OrthoDB" id="3259878at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH41337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="204" mass="22293" checksum="53DE5C9E3A088E98" modified="2018-01-31" version="1">MPRRPGARIHRLPQRLDYTLIPAPLDLSLPLVDEKAPLPAIIVTPSSPSHDGDFSIAFLMPPPKPSLLQRMANLLPSLPRLPPQIQLPPSPKPDFEQGTSCKTRARATILLLLLLFIMACHVIMHEIALDRPHMDFGVFSDTVLPSHVEVLNAHVDAKDTASPAVGGWFDLNALWAPTTVTSGKRAPEFVVVEDETAKAETNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JZ45</accession>
    <name>A0A2H3JZ45_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WOLCODRAFT_69241</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH41417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JZ45"/>
    <dbReference type="STRING" id="742152.A0A2H3JZ45"/>
    <dbReference type="OMA" id="RDFISVW"/>
    <dbReference type="OrthoDB" id="276151at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008854">
        <property type="entry name" value="TPMT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32183">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32183:SF6">
        <property type="entry name" value="CYSTEINE SULFINATE DESULFINASE_CYSTEINE DESULFURASE AND RELATED ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05724">
        <property type="entry name" value="TPMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51585">
        <property type="entry name" value="SAM_MT_TPMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PCH41417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="232" mass="25858" checksum="BDB8159CC8ADEDE4" modified="2018-01-31" version="1">MFEGIDSATSGIAGHPEQIRLRHIIKENQVDGWDKAWKGEVTPWDAGCAQPPLQDLIASGKLKLPKSGRALVPGCGRGYDALVIASELGLDTLAIDISPTAIEAAQRWEYAIQGSVTPKIDFQVKDFFSLGHSEEEHYELVYDYTFFVALPPALRADWGRQMAKIVKSGGYLIALLFPILNQPEDVGPPFYAREEHYSALLDGDWEKVLDEIPENSLVGHKGIEQLMVWRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K1S5</accession>
    <name>A0A2H3K1S5_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bola-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_74538</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BolA/IbaG family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468135">
        <property type="protein sequence ID" value="PCH42984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K1S5"/>
    <dbReference type="STRING" id="742152.A0A2H3K1S5"/>
    <dbReference type="OMA" id="VHAFSQK"/>
    <dbReference type="OrthoDB" id="4983at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BOL2"/>
    </dbReference>
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        <property type="entry name" value="BolA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036065">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR12735:SF27">
        <property type="entry name" value="BOLA-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12735">
        <property type="entry name" value="BOLA-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01722">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003113">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82657">
        <property type="entry name" value="BolA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH42984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="88" mass="9759" checksum="E60684C788C322FA" modified="2018-01-31" version="1">MPISSTELEGAIRSAIPITHLEIIDQSSGCGENYAVFVVSAAFEGKNTLARHRFINDLLKDQIARMHAFSQKTLTPKQYEVQQVKVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K1T8</accession>
    <name>A0A2H3K1T8_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6535 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_78410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468168">
        <property type="protein sequence ID" value="PCH45149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K1T8"/>
    <dbReference type="OMA" id="MSKNARI"/>
    <dbReference type="OrthoDB" id="3219854at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045338">
        <property type="entry name" value="DUF6535"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20153">
        <property type="entry name" value="DUF6535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6535" evidence="2">
        <location>
            <begin position="23"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH45149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="247" mass="27269" checksum="6E531137D7B8A697" modified="2018-01-31" version="1" fragment="single">MDRNIGSEGSKGTACAQTKSGTQVWEYERKTVDRRKDEIDNMLVFAALFSSILVAFIIDSYQDLKPEIPNESTLILRQILAQIASSTLGAEHMNATQPSFSDTPASASVGHPSFLTVVVNALWFAALVFSLMSASVGIAIRQWLNHHGDEPVGVEPLMSVRIWYVRRKGYLDWHVTGLLDLLPVLLQISVVLFLAGLVILLHSLNSIIAGIMTAQAAVLWTILFLTTIAPSIWCRCPYKSPQALWTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K263</accession>
    <name>A0A2H3K263_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_52864</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468135">
        <property type="protein sequence ID" value="PCH43134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K263"/>
    <dbReference type="STRING" id="742152.A0A2H3K263"/>
    <dbReference type="OMA" id="KQNCETI"/>
    <dbReference type="OrthoDB" id="3230070at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09276">
        <property type="entry name" value="Rnase_HI_RT_non_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH43134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="217" mass="25161" checksum="71B464B7EA22BD67" modified="2018-01-31" version="1" fragment="single">HILTNHPDTTTIHYFTDNTTALKTIYQAHKHPTQTNSILFINHTDALLSAHPNLTVILHWCPSHKGVPGNESADRLAKHATTLPSLHPPTLTWLRQRARRRALQRWQREFRSIPHYNPHSTRSLFQPSNALHPSIRKFTGTRNVQSRIIHCITSHGHYGEYYSRFVPTEPTSCHCDNRTFQTRDHILRDCPLHTHARHYLTRISPSITLHILLSTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K2G5</accession>
    <name>A0A2H3K2G5_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">WOLCODRAFT_144925</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">MD-104</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468157">
        <property type="protein sequence ID" value="PCH44328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K2G5"/>
    <dbReference type="STRING" id="742152.A0A2H3K2G5"/>
    <dbReference type="OMA" id="NSCRSWW"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="401"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PCH44328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="515" mass="57526" checksum="1818F954829473BE" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K6Q9</accession>
    <name>A0A2H3K6Q9_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_154163</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468157">
        <property type="protein sequence ID" value="PCH44127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K6Q9"/>
    <dbReference type="STRING" id="742152.A0A2H3K6Q9"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="731"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH44127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="795" mass="84683" checksum="A4DED09AD62092A6" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IUZ6</accession>
    <name>A0A2H3IUZ6_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycine cleavage system H protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WOLCODRAFT_62261</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">The H protein shuttles the methylamine group of glycine from the P protein to the T protein.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
        <text evidence="5">Binds 1 lipoyl cofactor covalently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the GcvH family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH33796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3IUZ6"/>
    <dbReference type="STRING" id="742152.A0A2H3IUZ6"/>
    <dbReference type="OMA" id="KEHEWIR"/>
    <dbReference type="OrthoDB" id="10264154at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06848">
        <property type="entry name" value="GCS_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00272">
        <property type="entry name" value="GcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002930">
        <property type="entry name" value="GCV_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033753">
        <property type="entry name" value="GCV_H/Fam206"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017453">
        <property type="entry name" value="GCV_H_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00527">
        <property type="entry name" value="gcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002270">
        <property type="entry name" value="PRK01202.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11715">
        <property type="entry name" value="GLYCINE CLEAVAGE SYSTEM H PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11715:SF3">
        <property type="entry name" value="GLYCINE CLEAVAGE SYSTEM H PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01597">
        <property type="entry name" value="GCV_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 5" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="6">
        <location>
            <begin position="55"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-lipoyllysine" evidence="4">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR617453-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PCH33796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="159" mass="17202" checksum="D502939FD7449901" modified="2018-01-31" version="1">MFSALRQVSRPATYAVRAARRPTPSVGVFRTAPFVRTLRFTEDHEAVVFDDSTMTGTVYITNYAQSSLGDVVFVELPAEGNKVTKGDQIGAVESVKAASDIYAPVSGTVTEVNAGLADQPGLLNKSPEDQGWLCKIKVENPAEIEALLTEEAYKAHCEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IVN7</accession>
    <name>A0A2H3IVN7_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mediator of RNA polymerase II transcription subunit 5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Mediator complex subunit 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MED5</name>
        <name evidence="10" type="ORF">WOLCODRAFT_129982</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Mediator complex subunit 5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH33791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3IVN7"/>
    <dbReference type="STRING" id="742152.A0A2H3IVN7"/>
    <dbReference type="OMA" id="LWRAFIV"/>
    <dbReference type="OrthoDB" id="5549158at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014801">
        <property type="entry name" value="Mediator_Med5_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35784">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35784:SF1">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08689">
        <property type="entry name" value="Med5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0010">Activator</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PCH33791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="928" mass="101036" checksum="6ECEB7C305472158" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IWJ7</accession>
    <name>A0A2H3IWJ7_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_148429</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH34370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3IWJ7"/>
    <dbReference type="STRING" id="742152.A0A2H3IWJ7"/>
    <dbReference type="OMA" id="FAHEGRD"/>
    <dbReference type="OrthoDB" id="3206554at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6534" evidence="1">
        <location>
            <begin position="2"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH34370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="117" mass="12680" checksum="63109CB6BA034F87" modified="2018-01-31" version="1">MAIACLICWLVFPGNLVFLALHFTISKVYANSLLATLNARNSLRDRALRSHTCASEIGAVAPGSDHHRYDSDDRSIEFYLAAYVNGKRDSADACDIGDQTVNEVGRYRMGGAEPGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IXE3</accession>
    <name>A0A2H3IXE3_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_78910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467832">
        <property type="protein sequence ID" value="PCH34642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3IXE3"/>
    <dbReference type="STRING" id="742152.A0A2H3IXE3"/>
    <dbReference type="OMA" id="IVSVMKM"/>
    <dbReference type="OrthoDB" id="420564at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35179">
        <property type="entry name" value="PROTEIN CBG02620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35179:SF2">
        <property type="entry name" value="START DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH34642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="399" mass="45859" checksum="E39413F7B7601CE9" modified="2018-01-31" version="1" fragment="single">GGEDIENEITNFECIGSYCWVNTEKPTITVPGSPPMWRDRALPYTVQPDGGTRFVDQNDFRVPSAVMYPLVRSVDIMAEEAGDEFDWKSVDFITDRNNLRKLLRWIHDGDIAEEFRIDTQLAGTKTVLLNRWERRSREAPYQNWNSYSLNYTRESTTPAPGCERCTSQYRIVKYASEICCCNIHARLFHSSQDFNGIRLVVRSAVDAFIAPISLSTSNAALDPDSVADLLSGMKISAPRSAAWRVDHAISTPELDVIRGGSRVPQDSIIEYKTRSVCSKGQLPNLCEDFYAQLFLSQTPHFYVAFHQHGRFETVIKRQLNDPEMKQIQDKLNNDFKMLREILVVIQRRVIEHGQRGRLSLVQQNGQLHVHERDSLESCLPEDLLKRFEWCVELHRVYEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IXW6</accession>
    <name>A0A2H3IXW6_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WOLCODRAFT_106585</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467832">
        <property type="protein sequence ID" value="PCH34806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3IXW6"/>
    <dbReference type="STRING" id="742152.A0A2H3IXW6"/>
    <dbReference type="OMA" id="WWISSIC"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF234">
        <property type="entry name" value="MFS-TYPE TRANSPORTER DBAD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="276"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="301"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="329"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="369"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="395"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="241"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PCH34806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="429" mass="46030" checksum="A77196F3ADB9A513" modified="2018-01-31" version="1">MTEVADHTDIPLSTLRPDDASSTSTLTISDGGLRAWLAVLGGYLVIFSTFGYSNSFGVYQDYYTLHGSSSSSDISWIGSLQLCLMFAVGLPAGRLFDRGYFRTTSVAGTLLYSFSLFMLSLASPQKFYQLLLSQGVGMGLGAGLLVVPAMSLQGHYWKKRRSLAMGLVAAGSGSGGLVYPIMLNRLFNGTLGFAWGVRVSAFVTFALLVIASCVMTTRTNGAKEDSQPPQPHISTVLTDVPYVLLVVGGFLSLWGLFFPYFYLQVWANVHGLSDNLAFYTIAILNAASVIGRMLPNMIADYAGMFNMIIPSTFITGALTFAMFGATSPAGVVVFAILYGFFSGASIALLPPTAASLAKDYHEIGLRLGVIYFVTSFALLTGTPISGALLDVHNQWPGPIIFNAVVLISGSVFMLISRQILAKRKCVCRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IXY2</accession>
    <name>A0A2H3IXY2_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycoside hydrolase family 16 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WOLCODRAFT_79265</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 16 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467832">
        <property type="protein sequence ID" value="PCH34591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3IXY2"/>
    <dbReference type="STRING" id="742152.A0A2H3IXY2"/>
    <dbReference type="OMA" id="HCTNDAF"/>
    <dbReference type="OrthoDB" id="4781at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF55">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 16 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="3">
        <location>
            <begin position="40"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PCH34591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="391" mass="44054" checksum="CECF93724B4824C5" modified="2018-01-31" version="1">MLTGEIEKPWITEKNLYARLSYWITWAVAMIGVAGGALRCYFGWKDVPRVGNLCLIMEDNFETFDLENTWTREVDMGGFGNGDFEMTTDSSNNSFVKDGKLYIMPTLTSDVIGYNNIFNGYTYNVSGCTSTNLTSCGAVSNITTGSVINPVMSSRITTMKSHSIRYGKVEIVAKLPTGDWLWPALWMLPVNNTYGPWPASGEIDIMEARGNGPSYGAQGTNYVRASLNWGPFSWLNGVSKTYGWWTTRRSTYAEGFHTYAVEWTPHFIRMYVDTRLDHMLQLSFNEPFFTRGDFPTTILNDSQYIVTPNPWVNGTPNVAPFDQPFYLIMDVAVGGTSGWFPDGVGNKPWLDASDSAMHDFAEAQDTWYTTWPETAEDRAFIIDSVKMWQSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IYX9</accession>
    <name>A0A2H3IYX9_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_107122</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467843">
        <property type="protein sequence ID" value="PCH35200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3IYX9"/>
    <dbReference type="STRING" id="742152.A0A2H3IYX9"/>
    <dbReference type="OMA" id="HVTCSTI"/>
    <dbReference type="OrthoDB" id="2550823at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH35200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="152" mass="16515" checksum="CF66BBF850416D06" modified="2018-01-31" version="1">MSQVAPNGRHPLSVVFLLHIALEVPVAVQGLLSPMSLPFIQLTNTTLVFIKMYSALVAGLCLAALLVFPLPEFLPGKRALGMALCFYHVTCSTILFNAPRFIPHSFGALAESYRATPEVVWGTLHGTIGLTLAIWWQLTVNMAAAVRKTAQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IZ70</accession>
    <name>A0A2H3IZ70_WOLCO</name>
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        <recommendedName>
            <fullName evidence="1">DUF6699 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_79777</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467843">
        <property type="protein sequence ID" value="PCH35021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3IZ70"/>
    <dbReference type="STRING" id="742152.A0A2H3IZ70"/>
    <dbReference type="OMA" id="TEMHELT"/>
    <dbReference type="OrthoDB" id="3241567at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046522">
        <property type="entry name" value="DUF6699"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20415">
        <property type="entry name" value="DUF6699"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6699" evidence="1">
        <location>
            <begin position="14"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH35021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="151" mass="17531" checksum="559BD005F068611A" modified="2018-01-31" version="1">MTAKHINARGSIVDFTSKLDDPVTHPPVRTVHIYCNSWMAHNQWGPIVIDKRRTVNVWDVLIAIYDFYRVPLTQQEVQHISSLDGDNYRRMLDAYYQRCMRTPALPGYEVQQGMKRADCLGRNTIFWGLWITLNADNTWQMNLGLVPPSHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IZF1</accession>
    <name>A0A2H3IZF1_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">galacturonan 1,4-alpha-galacturonidase</fullName>
            <ecNumber evidence="14">3.2.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">WOLCODRAFT_80111</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Specific in hydrolyzing the terminal glycosidic bond of polygalacturonic acid and oligogalacturonates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>[(1-&gt;4)-alpha-D-galacturonosyl](n) + H2O = alpha-D-galacturonate + [(1-&gt;4)-alpha-D-galacturonosyl](n-1)</text>
            <dbReference type="Rhea" id="RHEA:14117"/>
            <dbReference type="Rhea" id="RHEA-COMP:14570"/>
            <dbReference type="Rhea" id="RHEA-COMP:14572"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58658"/>
            <dbReference type="ChEBI" id="CHEBI:140523"/>
            <dbReference type="EC" id="3.2.1.67"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.67" evidence="14"/>
    <dbReference type="EMBL" id="KB467843">
        <property type="protein sequence ID" value="PCH35370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3IZF1"/>
    <dbReference type="STRING" id="742152.A0A2H3IZF1"/>
    <dbReference type="OrthoDB" id="187139at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047911">
        <property type="term" value="F:galacturan 1,4-alpha-galacturonidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736:SF12">
        <property type="entry name" value="EXO-POLYGALACTURONASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00502">
        <property type="entry name" value="POLYGALACTURONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 17" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 18" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013608224" description="galacturonan 1,4-alpha-galacturonidase" evidence="18">
        <location>
            <begin position="18"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="active site" evidence="16">
        <location>
            <position position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PCH35370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="425" mass="46108" checksum="A71267BBCA4C29D8" modified="2018-01-31" version="1">MLRGLLATVSLAAAAFAYDRVCTVVPLGGGQDDGPTINAAFKECSENAAVVLDSYYSVNTLLLTEGLSHVDIILNGTVQYTPDIAYWSPNSLYLTFQNATTFWFLSGDHIHLYGGGTIDGNGQVWYDYFNITQESGTAGSSTLTFARPIPLTIGNSSNVVIENITEWMSPNWACCTLSIWRDIITKSFTEQREYLREFSINSFSYSSAPAKNTDGWDIYRSSYVTITDSTINNGDDCVSFKPNSTDIIVSNLWCNGSHGISVGSLGQYAGETDIVANVYVKNVTMRYAENGARIKVFGGSPDPNSTSGGGTGYVKNITFEDFYSAYFSLITSNLFRRVQCYFTSTAQCEEYPSNLTISDVHYINVTGTSSGADGSVVVSLVCSEECEDITATSTNLTAPDGQATYVCENIASISELDFNCTSESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IZK6</accession>
    <name>A0A2H3IZK6_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_139872</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467843">
        <property type="protein sequence ID" value="PCH35376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3IZK6"/>
    <dbReference type="STRING" id="742152.A0A2H3IZK6"/>
    <dbReference type="OMA" id="RMPLMFG"/>
    <dbReference type="OrthoDB" id="6235964at2759"/>
    <dbReference type="UniPathway" id="UPA00315">
        <property type="reaction ID" value="UER00080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048269">
        <property type="term" value="C:methionine adenosyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048270">
        <property type="term" value="F:methionine adenosyltransferase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006556">
        <property type="term" value="P:S-adenosylmethionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05254">
        <property type="entry name" value="dTDP_HR_like_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000357">
        <property type="entry name" value="Methionine adenosyltransferase 2 subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005913">
        <property type="entry name" value="dTDP_dehydrorham_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029903">
        <property type="entry name" value="RmlD-like-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10491">
        <property type="entry name" value="DTDP-4-DEHYDRORHAMNOSE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10491:SF4">
        <property type="entry name" value="METHIONINE ADENOSYLTRANSFERASE 2 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04321">
        <property type="entry name" value="RmlD_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RmlD-like substrate binding" evidence="1">
        <location>
            <begin position="1"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH35376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="302" mass="33282" checksum="8604CD3E401DF471" modified="2018-01-31" version="1">MRVIVTGASGVLGSAVYSAYRSSGHTVLGLAHSRPTDDLKQLDLLKSLEVEKQFAEFKPDWVIHCAAERRPDVAEKDPEGARKLNAELPEHLAKLSKALKYTLVYISTDYVFDGTSPPYTPSAITNPVNLYGRTKRDGELAVLGVVGSKSIVLRVPVLYGPTPKNSDSAVNILLDVVSDQSGKQYKMDHYATRYPTNVVDIADFLVRLASLPTSQAIPPILHYSAGEPYTKYEMCLIFARILGLPHAHIVPDAEAPKGDAATTCPRDCQLYTRETEDLVEGYGGLGWTPFEEWWQGYLQAKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J044</accession>
    <name>A0A2H3J044_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_139975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467854">
        <property type="protein sequence ID" value="PCH35610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J044"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH35610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="78" mass="8415" checksum="660B6D3F37A40981" modified="2018-01-31" version="1">MDTLHRVHQRRARRGCRACCTGHTYGGAAQRQVRIAAQGRRVSGRAAGRPTPASAGPAAYDVDGRGSTWHPSRVFRCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J0E4</accession>
    <name>A0A2H3J0E4_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WOLCODRAFT_28089</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467854">
        <property type="protein sequence ID" value="PCH35720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J0E4"/>
    <dbReference type="STRING" id="742152.A0A2H3J0E4"/>
    <dbReference type="OMA" id="RHPDVDY"/>
    <dbReference type="OrthoDB" id="206201at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04077">
        <property type="entry name" value="Peptidases_S8_PCSK9_ProteinaseK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="entry name" value="Peptidase S8 propeptide/proteinase inhibitor I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034193">
        <property type="entry name" value="PCSK9_ProteinaseK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010259">
        <property type="entry name" value="S8pro/Inhibitor_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF11">
        <property type="entry name" value="CEREVISIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05922">
        <property type="entry name" value="Inhibitor_I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 6" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013749510" evidence="7">
        <location>
            <begin position="19"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="Inhibitor I9" evidence="9">
        <location>
            <begin position="53"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="8">
        <location>
            <begin position="176"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="217"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PCH35720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="498" mass="52568" checksum="D00AEB77644AB1BA" modified="2018-01-31" version="1">MFVFSSLLAVSLAAVGYATPLSTHPHDIPRERSSLPYAPLVVNEHPHGTVNNSYIVMLKDGVAPELLQNHVNFVQNVHVELPLMDDFESGLRHVYDGHVKGYAGKFSEGTVERIRQMPEVDYVELDQIVRTLEIDVEGEGTLGVQKNAPWGLARISHRPRLTFGTFRKYEYDVHGGEGVDVYVIDTGVNVKHNEFEGRATWGKTVPQGDVDEDANGHGTHCAGTIASRKYGVAKAANVIAVKVLGSNGSGTMSDVVAGVVWAAQAAAKKAEAALKEFAETGKTKHKGSVANMSLGGGKSQALDSTVNRAVDAGVHFAVAAGNDNKDACNNSPAAAEKAITVGASTLGDERAYFSNYGPCVDVFAPGLNILSTYIGHEDASASLSGTSMASPHTAGILAYLLSLYPSATFNPHVAPSFAPAPLQAQPLAQAYALAHSVLPSWVATFLPPPQLVAPVPTPAPTLTPKQLKLALLALATEGALMTVPKDTPNLLIFNNATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J0R5</accession>
    <name>A0A2H3J0R5_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">WOLCODRAFT_140073</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 13">Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467854">
        <property type="protein sequence ID" value="PCH35776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J0R5"/>
    <dbReference type="STRING" id="742152.A0A2H3J0R5"/>
    <dbReference type="OMA" id="DTSMVLF"/>
    <dbReference type="OrthoDB" id="282270at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001193">
        <property type="term" value="P:maintenance of transcriptional fidelity during transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006283">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10508">
        <property type="entry name" value="Zn-ribbon_RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019761">
        <property type="entry name" value="DNA-dir_RNA_pol-M_15_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012164">
        <property type="entry name" value="Rpa12/Rpb9/Rpc10/TFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001529">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034012">
        <property type="entry name" value="Zn_ribbon_RPB9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239:SF1">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02150">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005586">
        <property type="entry name" value="RNApol_RpoM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00661">
        <property type="entry name" value="RPOL9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01030">
        <property type="entry name" value="RNA_POL_M_15KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9 13" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4 10 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9 13" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS-type" evidence="14">
        <location>
            <begin position="71"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="11">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR005586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PCH35776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="121" mass="13731" checksum="8E2C0E76AC320BC9" modified="2018-01-31" version="1">MASLHFCSECNNLLYPKADPTRRAMVYACRICAFDMLGDNKCVYRDDLLTVTKEQIGVTTDLMNDPTLAHANMVCPECGHDDAVLFQDQSKRKETRMILFFVCTNCNHSYTDPIVARQNGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J113</accession>
    <name>A0A2H3J113_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_107343</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="LRR_dom_sf"/>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="9"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH35385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="414" mass="45931" checksum="B5164D8FE96702F5" modified="2018-01-31" version="1">MRTQNERFIPPELADKILDYLWDDPAALAACSLTCRAWVFNCRSHLFRKVDLTRAARRIRFAQVLSTSTGVGEHVRELTISGTILQSSEHAKMLHNLRGVKRLFLRNWDAGKTTREAYDTLQKLTPSITTLHLLSVIIDQQDFARLLSECRKLNDVRLWDVRVRTDAIDPPLPTTVAPTSDSVVVIDTLSSLTITSPAALAQMSDKISIRLRQLEVNCQLASPQSVERAKTLLCLGGPTLQSLVFTLRAGSYGPSWSDQLHFADIPNLTSLHLKDGMMSAPQIYTRRAPEYSLRWVCPALAQIDASHSHLQKIQISLRVFRAGDLDSCGLDWARLDDILAHIAKAHPRLVAEFCVCCTDAFGLWAKQAVDLIRAKTPQLCAASTNSAIVCCRGWTEEAALGGGVVGPSKKHDCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J241</accession>
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        <submittedName>
            <fullName evidence="8">Linoleate diol synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LDO2</name>
        <name evidence="8" type="ORF">WOLCODRAFT_134167</name>
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        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
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                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD-104</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="F:iron ion binding"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Haem_peroxidase_sf_animal"/>
    </dbReference>
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        <property type="entry name" value="Oxylipin_biosynth_metab"/>
    </dbReference>
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        <property type="entry name" value="Ppo-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11903">
        <property type="entry name" value="PROSTAGLANDIN G/H SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11903:SF37">
        <property type="entry name" value="PSI-PRODUCING OXYGENASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03098">
        <property type="entry name" value="An_peroxidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00457">
        <property type="entry name" value="ANPEROXIDASE"/>
    </dbReference>
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        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Heme-dependent peroxidases"/>
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    </dbReference>
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        <property type="entry name" value="PEROXIDASE_3"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2 7" id="KW-0349">Heme</keyword>
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    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="373"/>
        </location>
        <ligand>
            <name>heme b</name>
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        </ligand>
        <ligandPart>
            <name>Fe</name>
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        </ligandPart>
    </feature>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="1061" mass="118327" checksum="65A5666DA0D64ADA" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J307</accession>
    <name>A0A2H3J307_WOLCO</name>
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            <fullName evidence="7">Protein arginine methyltransferase NDUFAF7</fullName>
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        <name evidence="8" type="ORF">WOLCODRAFT_140365</name>
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        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:48108"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:88221"/>
            <dbReference type="EC" id="2.1.1.320"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NDUFAF7 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.320" evidence="7"/>
    <dbReference type="EMBL" id="KB467876">
        <property type="protein sequence ID" value="PCH36361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J307"/>
    <dbReference type="STRING" id="742152.A0A2H3J307"/>
    <dbReference type="OMA" id="LPFAPNM"/>
    <dbReference type="OrthoDB" id="17415at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035243">
        <property type="term" value="F:protein-arginine omega-N symmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003788">
        <property type="entry name" value="NDUFAF7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038375">
        <property type="entry name" value="NDUFAF7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049:SF5">
        <property type="entry name" value="PROTEIN ARGININE METHYLTRANSFERASE NDUFAF7 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049">
        <property type="entry name" value="PROTEIN ARGININE METHYLTRANSFERASE NDUFAF7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02636">
        <property type="entry name" value="Methyltransf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PCH36361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="524" mass="59845" checksum="AF2B6EFE7A562A7E" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J3A7</accession>
    <name>A0A2H3J3A7_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major royal jelly protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WOLCODRAFT_108725</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major royal jelly protein family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467876">
        <property type="protein sequence ID" value="PCH36451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J3A7"/>
    <dbReference type="STRING" id="742152.A0A2H3J3A7"/>
    <dbReference type="OMA" id="YIHPPIS"/>
    <dbReference type="OrthoDB" id="7776143at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017996">
        <property type="entry name" value="MRJP/yellow-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10009:SF18">
        <property type="entry name" value="PROTEIN YELLOW-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10009">
        <property type="entry name" value="PROTEIN YELLOW-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03022">
        <property type="entry name" value="MRJP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013729484" description="Major royal jelly protein" evidence="4">
        <location>
            <begin position="18"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PCH36451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="413" mass="44715" checksum="EA6D37A11710EF03" modified="2018-01-31" version="1" fragment="single">MPRLLPVLALWTAAAAAQSNTSVFDFPEYPPPGTPDPNSTLASGVEPLPYGIASDPALSDAYIHFDTGTYGPEIELVHAYYNYWPTGVGVASDGMIFTSFPRGNETFTLAIFNSSTTEAPWPNEEWNTPPAFANESNPGYSIATDKFLLVQSVVVDGLDRVWALDTGRPEVNGSYLLAQVPGGPKLVGFYMNGTNFATYTFPANVVYADSSINDVRFDLRGGGYAYITDSSPQRGGIVVLNLETGESWRHLDGSPSVTPDSSFVPVYDGVPFYLYPVTTPDAINNFGVYAADGIALSQDGEYLYFAPLASRHFWRIPTSYLKVQPGPDQPYAYLQAKQAVESLGESGSNADGLETDASGYIYGGAPEHNAVTRYNPSTGMFEPFVRSPVIQWPDTLSVVSLQSGGNYVYFTCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J3X0</accession>
    <name>A0A2H3J3X0_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_146478</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467898">
        <property type="protein sequence ID" value="PCH36942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J3X0"/>
    <dbReference type="STRING" id="742152.A0A2H3J3X0"/>
    <dbReference type="OrthoDB" id="3225203at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="373"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="637"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="674"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="724"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="807"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="932"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="319"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="637"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="760"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="948"/>
            <end position="964"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH36942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="964" mass="106228" checksum="6E66772E40327393" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J4Q2</accession>
    <name>A0A2H3J4Q2_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_157926</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467920">
        <property type="protein sequence ID" value="PCH37232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J4Q2"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH37232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="109" mass="12157" checksum="6DDCBBA41EAA69C0" modified="2018-01-31" version="1">MQKLLKFKLDDPKFLVFPLILFVQNHQTQAKSSYMFFNDEIAKTPNITISSSAQGTLQAELSAALSANGSEQAYKGQMETNVRSSSSPQANFELVLPKFRSLNLNLNLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J585</accession>
    <name>A0A2H3J585_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oxidoreductase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WOLCODRAFT_83116</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467898">
        <property type="protein sequence ID" value="PCH36825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J585"/>
    <dbReference type="STRING" id="742152.A0A2H3J585"/>
    <dbReference type="OMA" id="NEMQSPE"/>
    <dbReference type="OrthoDB" id="64915at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006740">
        <property type="term" value="P:NADPH regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055170">
        <property type="entry name" value="GFO_IDH_MocA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840:SF5">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22725">
        <property type="entry name" value="GFO_IDH_MocA_C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="2">
        <location>
            <begin position="5"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="GFO/IDH/MocA-like oxidoreductase" evidence="3">
        <location>
            <begin position="144"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PCH36825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="370" mass="39248" checksum="66B7DFE99A956F21" modified="2018-01-31" version="1">MAPVGVAILGSGIFAREGTSPVKPLVKAIYSRSEKSAAGLASAAESTLKLSAKPDIYHDGDSSANLDVLLARSDIAAVIVVLPITTQPGIILKALAAGKHVLSEKPVGKDVATGLELIKEYEEKYQPKGLIWRVAENLETETGYQAAAKAIRDGKIGKVVFYNARVVNYINRDSKWYNTPWRTVPDYQGGFLLDGGVHTLAALRVLLPSPIKTVSGVASLTKEFLTPQDTINAVVKSADGSHGLIELTWGAPTPSRSERAFNGITITGTNGWLSVNQVKVVDGARPVGGLRTTIQIAKRDKDGNDIGETEEIIDKTTDGVPNEIRFFVDAIGGSDNGLGTPRGALRDVAFIQAALNSNGSPIDLENLLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J5C2</accession>
    <name>A0A2H3J5C2_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_84409</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467931">
        <property type="protein sequence ID" value="PCH37406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J5C2"/>
    <dbReference type="OMA" id="WINISGA"/>
    <dbReference type="OrthoDB" id="2803426at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="257"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH37406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="447" mass="49590" checksum="53F2D495BA6CD0AE" modified="2018-01-31" version="1">MNYHTHQSGIFAILDGRYGDSPNTIAPPVEIYHPVFASFVAEDRDDTLGLPTDFVQKVAKLLRTVSQIATIERSREATTRSLLSDLLNLTIVQMVNRNSTSADYIVTYHRGSQPLGAAAIAIVEEKDELGSSGDASVQGSLAFIEHWTDSNQDALRAACFCPSFVIAVAGSWIVICGAVLTSSAIVHHLTDYIWLGHSRTVDDDRALRLARTFYALGRAIKRLESFYEGLVPPHDENARFFPLATAYKAGEQTINFKYVKPLKGSDASCATFLAAECEGARRRIVVKFVERYGERAHRLLAKERLAPELLYYGDIWLSGPEQRGCGPRKMVVMEYVAGMAAGDAAYENDGILPKGVHPAVQRAVSLLHEHGMVHGDVRPPNVIIEEYRKGRDVRDRVKIVDFDWAGEEGTVRYPLHLSTAIRWADGVDDYELITAAHDDKMVAKMQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J5G8</accession>
    <name>A0A2H3J5G8_WOLCO</name>
    <protein>
        <recommendedName>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
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                <person name="Morgenstern I."/>
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                <person name="Ohm R.A."/>
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                <person name="Sabat G."/>
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            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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        <property type="entry name" value="RRT5_SRSF_SR"/>
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    <dbReference type="PANTHER" id="PTHR23003">
        <property type="entry name" value="RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN"/>
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    </dbReference>
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        <property type="entry name" value="SERINE-ARGININE PROTEIN 55"/>
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    </dbReference>
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    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
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        <location>
            <begin position="3"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="95"/>
            <end position="168"/>
        </location>
    </feature>
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        <location>
            <begin position="151"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="165"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH37711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="294" mass="34548" checksum="B57A9D16263833AD" modified="2018-01-31" version="1">MARRLYLGRLPPDARAEDVSKFFDGYGRIVDCRVMTGFGFVEFESSRDAEDAVHHFNGKSFMGANIVVEFAKESRPRRDVYEADRAPRARRPPGFRLIVSGISRDTSWQDLKDFGREAGSVSYADIDRDVPGEGILEYLSRDDAERAVKELDGKDLRGQPVRVSLDTERAGPDNYRRDTRRDDRRDDRYGHGRDDRYGRDDRYGRDDRYAREDRFPKDDRYGDRKDDRAPYRRERSRSPRRSDHDDRRAPRSPPPRRDTDERRPVGDEKKRDEKDDRYDDRPPRHANGESGWAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J7B9</accession>
    <name>A0A2H3J7B9_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ketoreductase (KR) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WOLCODRAFT_107668</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD-104</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OMA" id="NYLANYH"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="18"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="242"/>
            <end position="275"/>
        </location>
    </feature>
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        <location>
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            <end position="380"/>
        </location>
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        <location>
            <begin position="420"/>
            <end position="454"/>
        </location>
    </feature>
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            <begin position="371"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="424"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PCH35673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="497" mass="54260" checksum="05A4753829DF9934" modified="2018-01-31" version="1">MVLQIAYAAVSAIFPTKYYVHIACASLVLLVAYAFAQGRTTNRERDLHARVVILTGAFTPLGLTLLTALATRGAHVIAISSYPLEHAYPSLIIPLLRTTTKNENIFAEHADLSNPASIREFCTRFLTGQDQRLDAIVFAHEYRGIGSIFGKSRNKAEELRETSSLATFLMLTLLLPALLVEPAERDIRIVNIINPFYAASTPLFPTTLSSGAQSPSLFLQEGARALRTAVLTRHLQRVLDSLPNREVTPDSRGTKKSSGTTSAQSPKGDEKPRALELQPSNIIAVSVCPGISRKDTIVPLLSAQQIDGTERSLVGFFIYVLLFPILWLFTKSPTASVQSVLHVIFLPTPLKRALAHIDATINPTQPPKGESSTDDKQGRPRVVYEEVVKPGALYRECAVVKVDVPPLPQAPAAAEIIEAPKSGTGEHKTKEKGKSKDKGKKLPQVTFPDDGEIGGEEVGRAVWEWYEEHLKVWEARFKAAEVKGEESEGQSGVDATS</sequence>
</entry>
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    <accession>A0A2H3J7K9</accession>
    <name>A0A2H3J7K9_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_155377</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
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            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467832">
        <property type="protein sequence ID" value="PCH34719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J7K9"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH34719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="55" mass="5724" checksum="60496A25E92AFEB8" modified="2018-01-31" version="1">MAAPPSARGGAAITARGREHPSTVRALVRRVGEGPRTSQTAGKAPNSPPPFYQLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J7N6</accession>
    <name>A0A2H3J7N6_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">2-nitropropane dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WOLCODRAFT_142485</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH38282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J7N6"/>
    <dbReference type="STRING" id="742152.A0A2H3J7N6"/>
    <dbReference type="OMA" id="RAKPKAW"/>
    <dbReference type="OrthoDB" id="6262491at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332:SF31">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G09850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PCH38282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="359" mass="38106" checksum="0C7CB0B7777D3E67" modified="2018-01-31" version="1">MPSSPQVFRTPLTERFNINHPVMLAGMNVAAGAKLAAAVTNAGGIGVIGGIHYSSKMLQDVIDDMKSQLENKDAPFGVDLALPQVGGNARKTNYDYTKGQLPELTDVIIRSKASLFVSAIGTPPKEMVDKLHAAGIVVMNMVGHPKHVPRALAQGVDMICAQGGEGGGHTGDTPFSILVPAVVDLCKNAKSPLTGEPIIVVAAGGIADGRGLAAALSYGASGVWVGTRFVASEEAGAPRIHKELVISAGYDDVGRTLIFSGRPLHVRRTPYVIEWESRQEEIAQLTSQGKIPHDVEMERNPEKAKDGHQWLMGKVAGSITEVKPAKEIVDELVSTAAQSLQRSNGLIVAKSGWWPKLHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J7P4</accession>
    <name>A0A2H3J7P4_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_156489</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467854">
        <property type="protein sequence ID" value="PCH35793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J7P4"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH35793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="165" mass="17751" checksum="C6E12FD9DB092D38" modified="2018-01-31" version="1">MRRAGRVRPGGPGLAAAYRVSDDDDAPSVHPRPRFPAARQRIGFSKPRSGYICIVRLPGAPPARLCPSRAPSSGAVRTPRVLSGQRRPRRKSEINARVQCAEPEPGGGRTMVARASQHAHGTSDPMGLIPAHSRQLVRHCLICICVRAGALSSPHSITYHAPLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J874</accession>
    <name>A0A2H3J874_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ras-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_66607</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH37825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J874"/>
    <dbReference type="STRING" id="742152.A0A2H3J874"/>
    <dbReference type="OMA" id="ANGVMQY"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001329">
        <property type="entry name" value="Small GTP-binding protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="191"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH37825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="218" mass="23996" checksum="E0A642B17044CCC0" modified="2018-01-31" version="1">MAGVAWHYVLKFIITGDSSVGKSSLLVRLTDQRFLADPDPTLGVEFGSKLITIPEENKVVKLQCWDTAGTESFRSITRSYYRGAAGCLLVYDVTSRQTFLNARSWLADVREHADPHLTCILVGNKIDLCTGDGPGKRSCEVPTEEAQLWAQEEGLLFVEASARSGENVEAAFEQATRDILDKIRRGVFDDDRSPGVKLSKPSNPEVSLESDAPRGRCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J8I5</accession>
    <name>A0A2H3J8I5_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6535 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_65668</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
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                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
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                <person name="Wiebenga A."/>
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                <person name="Eastwood D.C."/>
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            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
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        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
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            <begin position="6"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF20153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH38516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
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</entry>
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    </organism>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
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                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
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                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
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                <person name="Sabat G."/>
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                <person name="Sun S."/>
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                <person name="Wiebenga A."/>
                <person name="Young D."/>
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                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
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    </dbReference>
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            <end position="40"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="120" mass="13949" checksum="B2786EA1F4BCD10E" modified="2018-01-31" version="1">MALLCYEYFLTLGREIQYVWKVNCSFASVLFYTWRYSVLLCVLPATLDLVHPASWQTNDNGVEALLDHAIGFKRANNSQFIGMQVGLTIRCSYSMVLMLLNLEMYRTSRDRNSGSFYFYL</sequence>
</entry>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
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                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
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                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Luc7 family.</text>
    </comment>
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    </dbReference>
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        <location>
            <begin position="237"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="243"/>
            <end position="252"/>
        </location>
    </feature>
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        <location>
            <begin position="269"/>
            <end position="306"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00005655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH38175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="313" mass="35673" checksum="B6DC318B597DC3EC" modified="2018-01-31" version="1">MGRLAEMQRKLLEQMMGPEAMGVANANLTWSDEKVCRNFLCGTCPHTLFTNTKMDLGACPKSHTERLKTEYLQAKEANPNDPIFARFQMEYESNIFAFVDECDRRIRAAHRRLEKTPEENAKTTNLMREIAEIELAIQGGTEKIETLGEQGKVDESMREMAAIEALKSEKADKERELQQLTDTSGASGHQKLRVCDVCGAYLSVLDSDRRLADHFGGKMHLGYHELRNMLIKFKEEREKRKMAPPSSVPAAGSGSGGIPPAPSGVPPRGGDRDYRSSRDDFRDRERDRGYDRHSSRYDERRRDRSRSPGRRRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
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    <name>A0A2H3J9Q4_WOLCO</name>
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        <recommendedName>
            <fullName evidence="3">thioredoxin-dependent peroxiredoxin</fullName>
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        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Thioredoxin peroxidase</fullName>
        </alternativeName>
    </protein>
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        <name evidence="16" type="ORF">WOLCODRAFT_29294</name>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
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                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
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                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
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                <person name="Kohler A."/>
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                <person name="Kumar T.K.A."/>
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                <person name="LaButti K."/>
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                <person name="Lindquist E."/>
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                <person name="Lucas S."/>
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                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the peroxiredoxin family. BCP/PrxQ subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.24" evidence="3"/>
    <dbReference type="EMBL" id="KB467943">
        <property type="protein sequence ID" value="PCH38970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J9Q4"/>
    <dbReference type="STRING" id="742152.A0A2H3J9Q4"/>
    <dbReference type="OMA" id="CGFRDNF"/>
    <dbReference type="OrthoDB" id="338622at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03017">
        <property type="entry name" value="PRX_BCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000157">
        <property type="entry name" value="DOT5p Nuclear thiol peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050924">
        <property type="entry name" value="Peroxiredoxin_BCP/PrxQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42801:SF23">
        <property type="entry name" value="PEROXIREDOXIN DOT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42801">
        <property type="entry name" value="THIOREDOXIN-DEPENDENT PEROXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="9" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="15">
        <location>
            <begin position="84"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="64"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00077538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PCH38970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="231" mass="24700" checksum="EE2E5AADFFA227B6" modified="2018-01-31" version="1">MPRTAKNASDPAEPTRRSSRISAQPKAEVKEPAKKPAAKPKKRSADAVEGEDNPATKKSKAEEAAAEAEDTEEADEEAAKLATIDIGGQLPSLTLKNEKGEDVEVADLAAEKGVILFLVPKADTPGCTNQACGFRDIYPDFTSHNFDVYCLSADSPSAQTKWQTKKNLPYPLLSDPKRTLISALGAGEGGKTKRSHFVFEKGGKLVDKKIPVKPADSPKLALDFVKTLVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JA40</accession>
    <name>A0A2H3JA40_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">pectinesterase</fullName>
            <ecNumber evidence="3">3.1.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WOLCODRAFT_165643</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD-104</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Glycan metabolism; pectin degradation; 2-dehydro-3-deoxy-D-gluconate from pectin: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pectinesterase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.11" evidence="3"/>
    <dbReference type="EMBL" id="KB467832">
        <property type="protein sequence ID" value="PCH34538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JA40"/>
    <dbReference type="STRING" id="742152.A0A2H3JA40"/>
    <dbReference type="OMA" id="TWAQANH"/>
    <dbReference type="OrthoDB" id="2019149at2759"/>
    <dbReference type="UniPathway" id="UPA00545">
        <property type="reaction ID" value="UER00823"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030599">
        <property type="term" value="F:pectinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042545">
        <property type="term" value="P:cell wall modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000070">
        <property type="entry name" value="Pectinesterase_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31321">
        <property type="entry name" value="ACYL-COA THIOESTER HYDROLASE YBHC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31321:SF137">
        <property type="entry name" value="PECTIN METHYL ESTERASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01095">
        <property type="entry name" value="Pectinesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0063">Aspartyl esterase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013864032" description="pectinesterase" evidence="6">
        <location>
            <begin position="23"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="Pectinesterase catalytic" evidence="7">
        <location>
            <begin position="161"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PCH34538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="388" mass="42377" checksum="15CBDC79A91A7A0F" modified="2018-01-31" version="1">MLSIRTLLVLSGLFHCCIPGLALNYDRFLCQYPTSDPLEGCPPNTLLVGPSSQANFTSIQSAVLSIPNDTTPYTILILPGNYSEQINVTRVGPLTLLGQTLEPTSRAQNAVAVYWAAVAGTGDNAYTSTLTIAPTLNASLTGSGPDGNPVPAGTPFGNTDFRIYNIDFVNDYAPYSDGPSLAVSVSYANTGFYYCGFYSYQDTVYIGKLGNAYFYESEVAGQTDFFYGFGTAWVQSSLVTLRGCGGGITAWKGTNTTFENKYGVYIHDSVVMKANSSLEIEGQCALGRPWNSQMRAIFANNYLDDSIRPSGYIPWESDTSRIDFNTTMAEYGDFGPGFNLTGRIEGNITLLMTEEEYEPYDRVEKVFQFPFNGTYGNVAWIDFAPSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JAA5</accession>
    <name>A0A2H3JAA5_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_167836</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467965">
        <property type="protein sequence ID" value="PCH39170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="742152.A0A2H3JAA5"/>
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    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GDHRDH"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH39170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="322" mass="35346" checksum="C3C74EE744D57B6F" modified="2018-01-31" version="1">MSPKSFNPEELPDLSGKVIVVTGGNAGVGYAVIQHLARRGAKVYMAARSQERAVAAIDRLRSSGLGPGNGDIHWLPLDYSDPRLAKQAAEVLMEKEARLDIVVNCAALLLIPYKKSHDGIQDIVMVNYLSPTVFIRALLPLLERTAQEPNSDVRIVEVLSEGHRNAPKGVRFRNIDDFNAEFKDASFQRLARYGLSKFMGMLHVKELQRRLDEEGVPIIVLSVHPGVVNTEGVQAYTHSVGPVLSPIYTFIANSFFSTPSQGAYGPVFAAAAPVVRAEAQRYRGAYILPPSKLARADKRTEDRELAKELWDTTESILSGIGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JCC8</accession>
    <name>A0A2H3JCC8_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Ribosome biogenesis protein NOP53</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WOLCODRAFT_146647</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">May play a role in ribosome biogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
            <location evidence="5">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
            <location evidence="5">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the NOP53 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467931">
        <property type="protein sequence ID" value="PCH37463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="742152.A0A2H3JCC8"/>
    <dbReference type="OMA" id="TEKWTHK"/>
    <dbReference type="OrthoDB" id="5072at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011687">
        <property type="entry name" value="Nop53/GLTSCR2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14211">
        <property type="entry name" value="GLIOMA SUPPRESSOR CANDIDATE REGION GENE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14211:SF7">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN NOP53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07767">
        <property type="entry name" value="Nop53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017302">
        <property type="entry name" value="Gltscr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="298"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR017302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PCH37463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="444" mass="49825" checksum="70DB57A26300BCE9" modified="2018-01-31" version="1">MSVKPAPTHAPSTAKTKNAASSVGAPAQHNQSSRKGKKAWRKNVNIEEIEEGMEGLRAEERVTGSILQKKTDQELFQIDVKGDEHVRKARSKFSNSLLTSAKILAQRSAVPAVHSRASSASALKRKTPTYDEKGRLLRISKRQRRGLFNTVVDTTKVGAGSALMELSEAAKKSGTYDVWTDSVEGTNVKPPSTPHPRAHITLPAVPSPHEGTSYNPLVSSHQELLRTAHEIEEQRVKKAAELNKFKAQMAAASRLATIDEPKGVAPGMLVDEVREGEEDVDAEPTGERVVKKMPARKTKQQRRKAERLRAERRALEEKRARKRTLASIDSAKSMRKALKRSMAARERLHAQRHEAELEKRKKGLAGQRVGKHKVPEGEIDVQLGDELSESLRALKPEGNLFRDRFLSMQHRALIEPRVPILTKQRRAKMKEYEKHAWKRFDREQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JCM1</accession>
    <name>A0A2H3JCM1_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphatidylglycerol/phosphatidylinositol transfer protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_161978</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
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            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468053">
        <property type="protein sequence ID" value="PCH39946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JCM1"/>
    <dbReference type="OMA" id="KCYSSED"/>
    <dbReference type="OrthoDB" id="2841294at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013864026" description="Phosphatidylglycerol/phosphatidylinositol transfer protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH39946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="147" mass="15868" checksum="ED30087C1D680F5A" modified="2018-01-31" version="1">MKYLAVLTALAAACYAQTGLVIETNTNGTVSPGQNMTVVVLKPTESAPSIEVAIVIAMTQCPDQDCSSPSFNISQDLERVLYYGPYNPQYSSNRTEPQHQNFTVQVPQTPFESGDKVALSVTRFALDESAAGDSVVVQTPFITMNID</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JD12</accession>
    <name>A0A2H3JD12_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6589 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_88293</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468053">
        <property type="protein sequence ID" value="PCH39771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JD12"/>
    <dbReference type="STRING" id="742152.A0A2H3JD12"/>
    <dbReference type="OMA" id="DSCFSEW"/>
    <dbReference type="OrthoDB" id="4743193at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046496">
        <property type="entry name" value="DUF6589"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20231">
        <property type="entry name" value="DUF6589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6589" evidence="1">
        <location>
            <begin position="1"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH39771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="419" mass="47482" checksum="875C41EF76CD31C4" modified="2018-01-31" version="1">MDINQSTIQGNADALLSLFQQAGIGDTAESPYVRDIGDYVQIVHGDIGTGECIQSLLASHGEETTPWHRFQPVIFVMGLFHLKMACADAIWKIFISPRNARNDDTSLSKQVAEIHPNETSKIASKPGFRHMHEIIQHVGIASCLDCWREEICQHNSLINDLEVWAASRPTLNEIQSITIILAKKYLPDKNASDAFFNPSEQQDQVHNNISMREQYFLLYEELSYALNAGDIGHVETCFILWAFIFKGCGKHKYATHLIRFLYDLHYVYPHGLSHAVQMNILCNPTGKPFHYHAIDWLVEHNNLYTKCIYGGHFSNRTKARILKESALIEFENMFALNHCTYQHSPPKMTKTLAKLALYMLKTNTHKTVPGRKALYLIPEAMQEGKHKLVAAKEIAYEIGLDAESNVELEVDGENGDLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JD77</accession>
    <name>A0A2H3JD77_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_127533</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467887">
        <property type="protein sequence ID" value="PCH36689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JD77"/>
    <dbReference type="STRING" id="742152.A0A2H3JD77"/>
    <dbReference type="OMA" id="CEMEPVY"/>
    <dbReference type="OrthoDB" id="3147752at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH36689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="331" mass="37078" checksum="ECEDC7EC4EF46246" modified="2018-01-31" version="1" fragment="single">MEETKRDQRQKQLELRTLDRIHKETLTLLETRTADLHDAQVYLTKTDYVSDAEVVAMVEQLNAKIFQAASHIADSIDFESVVQHSIPQATEKATERATALVGEALVGYLQLARHRDDSFCLQLALQAGMVAFSSWIATTWTFVQDKGKVTFDRVYAQMRSSESQTVAGRWRILARQHARRVLYEDDEVTPYLTKCLARRIVDIFAVSGLQFEGAEDASRTFVSTTHGDRLKSLVESCLQLRRIMGEEVISGDFETIVVAPGEKFDEAHSTDGYANLEDDSPSAMDRQVLCTTAMGLQRVVQVGNTDTEYALHTTILLKPTVALETLGPELC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JDD6</accession>
    <name>A0A2H3JDD6_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">D123-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_98578</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDC123 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468053">
        <property type="protein sequence ID" value="PCH40250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JDD6"/>
    <dbReference type="STRING" id="742152.A0A2H3JDD6"/>
    <dbReference type="OMA" id="SGVIMEM"/>
    <dbReference type="OrthoDB" id="360540at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009772">
        <property type="entry name" value="CDC123"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15323:SF6">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 123 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15323">
        <property type="entry name" value="D123 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07065">
        <property type="entry name" value="D123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="81"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH40250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="372" mass="42044" checksum="3CEFD51B2C54A561" modified="2018-01-31" version="1">MPTVVSTLALFPQLTPESVLAFQFSSWYPRFSSLSIKSTIIRPLGQDFLDYLDSDGVFLPEGAEDVSVTLVRSCRPAESTLSDDEGDEEEEDEAEDERQKFAFPELDAQIRDAVEKYGAVFPKLNFSSPRDAAWMLPASSPMKCTSPADVYLLLKSSDFVEHDLSTEHVFDGCEPQSRTAGSDRAGPEYNIELVLRKWYPVDRSRELRCFVRQEKLLGISQRDPNYYDFWSESGTQSKVLDALTSYWESNIRGRWGESNGDYTFDLLLTRDLSRAHIVDFNPYAPRTDPLLFTYDELYALLLARTNSALDATPELRVVDSPSHPAATRNAPAHQHNMVPIEALAMSSGRSVEEFAGLWQEEMQKSMQGDDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JDG9</accession>
    <name>A0A2H3JDG9_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Non-structural maintenance of chromosomes element 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WOLCODRAFT_106472</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the SMC5-SMC6 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NSE4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467832">
        <property type="protein sequence ID" value="PCH34744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JDG9"/>
    <dbReference type="STRING" id="742152.A0A2H3JDG9"/>
    <dbReference type="OMA" id="FMGINRT"/>
    <dbReference type="OrthoDB" id="361242at2759"/>
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</entry>
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                <person name="Barry K."/>
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                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
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                <person name="Yadav J.S."/>
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                <person name="Benoit I."/>
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                <person name="Ohm R.A."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">MD-104</strain>
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    </reference>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="148" mass="16283" checksum="4CA54EEB8BBCF6A2" modified="2018-01-31" version="1">MNAFSGVASESPAAKIWFSYLELVSVVSCLPPSLLVALRCCMAVVICHPLGGDSDCIVHSAIASEGVGHCCTLPSRPHHRLFIVLNTFASVQATLSIFHIIPRLSVIPKMRTRPHQPVKTVHIVPCTWRRTRTVFAQDRERPSAALKF</sequence>
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            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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    </dbReference>
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    </evidence>
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        <source>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <evidence type="ECO:0000313" key="1">
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            <dbReference type="EMBL" id="PCH40486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="200" mass="20803" checksum="82660887619886B4" modified="2018-01-31" version="1">MTGSLAVAADVAVPREALKHSKAAIRLIANDVVPQTTPVNSGPSSDSPSAFPSPLGTVLPALPERVTCPRHNVCAPESTSARAQIALGPFSAAASTTSYCTHARARRPPRLSTLARAACVAWWRSSARVRAGRTIAAWRRGCHGMWGRLRSSAIARTGTGSASLDRCDRGAKLSTGIAPHCGQFDFSAFPASQSASSPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JFB5</accession>
    <name>A0A2H3JFB5_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dipeptidyl-peptidase V</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WOLCODRAFT_23934</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S9C family.</text>
    </comment>
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        <property type="protein sequence ID" value="PCH40235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="S9 family peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42776:SF13">
        <property type="entry name" value="DIPEPTIDYL-PEPTIDASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42776">
        <property type="entry name" value="SERINE PEPTIDASE S9 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013594833" description="Dipeptidyl-peptidase V" evidence="6">
        <location>
            <begin position="18"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="7">
        <location>
            <begin position="538"/>
            <end position="750"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PCH40235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="755" mass="83619" checksum="1807E1A522354F7A" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JG77</accession>
    <name>A0A2H3JG77_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ATPase AAA-type core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_16953</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH41200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JG77"/>
    <dbReference type="STRING" id="742152.A0A2H3JG77"/>
    <dbReference type="OMA" id="LWNDKWR"/>
    <dbReference type="OrthoDB" id="9996895at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389:SF21">
        <property type="entry name" value="ATPASE FAMILY AAA DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389">
        <property type="entry name" value="CHROMOSOME TRANSMISSION FIDELITY FACTOR 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase AAA-type core" evidence="2">
        <location>
            <begin position="230"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="298"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH41200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="740" mass="81720" checksum="BB7007750BC5F1BD" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JGE2</accession>
    <name>A0A2H3JGE2_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase C14 caspase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_21243</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C14B family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467943">
        <property type="protein sequence ID" value="PCH38913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JGE2"/>
    <dbReference type="STRING" id="742152.A0A2H3JGE2"/>
    <dbReference type="OrthoDB" id="3223806at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050452">
        <property type="entry name" value="Metacaspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104:SF30">
        <property type="entry name" value="METACASPASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104">
        <property type="entry name" value="METACASPASE-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C14 caspase" evidence="2">
        <location>
            <begin position="155"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH38913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="461" mass="50761" checksum="AE987D1DA58CDEB1" modified="2018-01-31" version="1">MEYAMIKQGCIRHKAVPLLRSQELLQADKRTNTSMLHCAQQFVSQISRAWGTASCASGGARMPVACLDWSKSSSSVTSRGVGRSPCRAILVHPGEVLTHPVAAWVDYNKPLPNLPPGESPILQPYQLDIPAVLNNNGIEVSVPQPWIYCSKTGVFALIISIDIYEDPDIIDLSGCVNDGESVKSYLKEALQASEENILFLQNEAARRCDIISAIRTHLITNEAISFGDSIIFYFSGHGGREEAFGEAEEHMTETFRPYDYHTVDDHGNVVHGISNRAFDELMRELAHEKGNNITAIFDSCYAGGMMSAPGTAPYTGRDSRSRGLSARMGIAPSPVESWYSVTPSYVLLAACRPEETAREEGPDGEATGVFTSALLKTLREYPLGELTYSRLVELLPGMPDQHPICEGINRERVLFEAAVTTEDRWSVYGPVIEERSQTFRVHQEDNGFVVVEPCSMNGIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JGK7</accession>
    <name>A0A2H3JGK7_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_92144</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467898">
        <property type="protein sequence ID" value="PCH36828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JGK7"/>
    <dbReference type="STRING" id="742152.A0A2H3JGK7"/>
    <dbReference type="OMA" id="GVMEPFV"/>
    <dbReference type="OrthoDB" id="2537769at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012808">
        <property type="entry name" value="CHP02453"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02453">
        <property type="entry name" value="TIGR02453 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36452">
        <property type="entry name" value="CHROMOSOME 12, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36452:SF1">
        <property type="entry name" value="DUF2461 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09365">
        <property type="entry name" value="DUF2461"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="385"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH36828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="416" mass="46381" checksum="4AF7DC7AF754A70B" modified="2018-01-31" version="1">MAPRSPPKRQASRPTTTAPQPGATRTRRSRHFPAHESDHGGEDEAEDGRVGGEDAASEYEDEDEEDARSLHSDALDDDDDYIRPAGSVRKRKRAASSASPAKRSAKAKEKAKKSPRKKRRGGAESADESEDALNLKDGQEVVGVVVQAPKTGRVPPGRISRNTLDFLKQLQRPECNDREWCPVYRLAESEWKAFVDEFTPRLVDADPQIPHLPARDVIHRIYRDVRFSNDKTPYKTGFSASFSRSGRKGIFAHSRTVEPGNESLIAAGAWCPGKNELATIRSNLLRSSARLRRIIAAPEFVRFFGEPRPRPGGARQSLFGREDELKVAPKGVDKTHPDIDLLKCRSFAVIHQFADSEVLEPDFVEKLIEVVRVTRPFVRCMNDLMTLQDGGNDDDDEDGDESADEDGDENEAEEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JGS6</accession>
    <name>A0A2H3JGS6_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_96208</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH37969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JGS6"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH37969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="50" mass="5791" checksum="367B468099572A64" modified="2018-01-31" version="1">MQVQLSASTLAHAQICCVQNTRDDVQYRSRGCVRWRGAETVLLVPWHRLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JH63</accession>
    <name>A0A2H3JH63_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_156767</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467865">
        <property type="protein sequence ID" value="PCH36044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JH63"/>
    <dbReference type="STRING" id="742152.A0A2H3JH63"/>
    <dbReference type="OMA" id="RCHATAR"/>
    <dbReference type="OrthoDB" id="2757268at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046521">
        <property type="entry name" value="DUF6698"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20414">
        <property type="entry name" value="DUF6698"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="467"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="467"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="484"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH36044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="588" mass="66967" checksum="0000B208E159C99F" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JHE2</accession>
    <name>A0A2H3JHE2_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GroES-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WOLCODRAFT_166266</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD-104</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467843">
        <property type="protein sequence ID" value="PCH35417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JHE2"/>
    <dbReference type="STRING" id="742152.A0A2H3JHE2"/>
    <dbReference type="OMA" id="PKTYKAM"/>
    <dbReference type="OrthoDB" id="1560166at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF7">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE-LIKE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="6">
        <location>
            <begin position="19"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PCH35417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="341" mass="36411" checksum="9CC64C501AADDAB7" modified="2018-01-31" version="1">MSFAPPKTYKAYAFKERGGKLEEIELEWQDPKAGEVVVKVLACGVCASDTCVQTQAFPSVVYPRVPGHEIIGDVVAVGEGEQLWKFGDRVGAGWHGGHCHNCTRCRKGDYVTCSLSSQPNGIARNGGYAQYVTLRSEALANIPRDMDPAEAAPLMCAGVTTFCALRSSTVPGPEIAAIQGIGGLGHLAIQFARHMGYRVVALSTSDSKRELALQLGAHEFISGTGAEQAAALQKLGGARLVAATAPEPDAINPLIDGCTFDSEILVLPVDSRSLTIPIMPLLGKRLSVRGWPYGSGQDCEDTVQFARAHGIKSIVETFPLEKAAEAYERRASAKFRSVIIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JHZ9</accession>
    <name>A0A2H3JHZ9_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="7">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WOLCODRAFT_118396</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD-104</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="7"/>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH41185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JHZ9"/>
    <dbReference type="STRING" id="742152.A0A2H3JHZ9"/>
    <dbReference type="OMA" id="LPEVWDM"/>
    <dbReference type="OrthoDB" id="8118055at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044322">
        <property type="term" value="C:endoplasmic reticulum quality control compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904380">
        <property type="term" value="P:endoplasmic reticulum mannose trimming"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044674">
        <property type="entry name" value="EDEM1/2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45679:SF5">
        <property type="entry name" value="ER DEGRADATION-ENHANCING ALPHA-MANNOSIDASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45679">
        <property type="entry name" value="ER DEGRADATION-ENHANCING ALPHA-MANNOSIDASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013957756" description="alpha-1,2-Mannosidase" evidence="8">
        <location>
            <begin position="22"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="9">
        <location>
            <begin position="740"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="291"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="386"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="405"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="491"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PCH41185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="886" mass="99291" checksum="1D789A692B57E689" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JI81</accession>
    <name>A0A2H3JI81_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6593 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_115523</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="3183898at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="DUF6593"/>
    </dbReference>
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        <property type="entry name" value="DUF6593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6593" evidence="1">
        <location>
            <begin position="36"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH38459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="181" mass="20735" checksum="D3E7CB47F7DAA0E5" modified="2018-01-31" version="1">MAAAGPNHLFFTSKDDPREDCIIIGFTYNAPTNQGSDKPIFYRFTTSQVSQTDSRTIVTRDAGQVVAQLDWPMHNQLGMITMGTKPQHPMSWMMMRGSTPNVRIFRSADSQLYEWRKVLNRPDSYDLFSGNTQIARFQREAKNTPIGPAHAVMQYIFDNDELLLECLVALCVNRWVDLRLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JII8</accession>
    <name>A0A2H3JII8_WOLCO</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_72899</name>
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        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
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        <lineage>
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            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="248"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH41992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="275" mass="30879" checksum="A9ED68248ACB7C84" modified="2018-01-31" version="1" fragment="single">HDKVNITWLVRKLEKTVADEDWNASGILPPNTWIKTRTTLQKLKYAWKLLNNVEMLEDDLESPKRYEQLRKLLERLDNLVTEADQCVKPVSKGSSPLLHMLPLHVSSLPKPIITTPESPIPAQPGRPAEDPIFSDAITPAPVHPIQRQHFSRIRAPFLCPPTFPTVSPDISSGAPAFKQNSAAIQEERLSAQLAEMATQLQRNAAHFAGMLEKDKTVVLEVQEKLECNYGAMSRERIRVRDHNRSKSWGTSGIVLLSIVVALVGFIMMFCAICFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JIJ6</accession>
    <name>A0A2H3JIJ6_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alcohol dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.1</ecNumber>
        </recommendedName>
    </protein>
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        <name evidence="10" type="ORF">WOLCODRAFT_72414</name>
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        <name type="common">Brown rot fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD-104</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="742152.A0A2H3JIJ6"/>
    <dbReference type="OMA" id="LMAGHWV"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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    <dbReference type="GO" id="GO:0046872">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Alcohol dehydrogenase AdhP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF3">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="9">
        <location>
            <begin position="38"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="8">
        <location>
            <begin position="190"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PCH42002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="297" mass="31320" checksum="A97726987C4C33F4" modified="2018-01-31" version="1">MPAATVPSQTRAAVTREFSIKADLTDAYPLKSPSELAPGECIVKLEYTGVCHSDLHFMAGEWAIKPRLPSVGGHEGVGHVIAINNLYSGNVRVGDRVGIKYCIRSCLNCDQCRRGFEQNCPERIISGFHVDGTFAEYMVAFTDHLIPIPDGLDSAAAAPILCAGVTVYNSLTKLDTPVGGWIVIPGAGGGLGHLAIQYAIARGLRVLAIDAGSKRELCLSLGAEAFIDFTECTNIVSAVQTAVGDPLGAHAAIITTASNAAYVQAGWYVRPQGTVLCVGVVQEVSGLPMARIIDAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JIQ5</accession>
    <name>A0A2H3JIQ5_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Topoisomerase I damage affected protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_137381</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH41415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JIQ5"/>
    <dbReference type="STRING" id="742152.A0A2H3JIQ5"/>
    <dbReference type="OMA" id="DSLICIC"/>
    <dbReference type="OrthoDB" id="10260741at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21449">
        <property type="entry name" value="DLC-like_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.40">
        <property type="entry name" value="Tctex-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005334">
        <property type="entry name" value="Tctex-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038586">
        <property type="entry name" value="Tctex-1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21255:SF7">
        <property type="entry name" value="DYNEIN LIGHT CHAIN TCTEX-TYPE PROTEIN 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21255">
        <property type="entry name" value="T-COMPLEX-ASSOCIATED-TESTIS-EXPRESSED 1/ DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03645">
        <property type="entry name" value="Tctex-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH41415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="133" mass="15194" checksum="E1A765E43E4DA3FD" modified="2018-01-31" version="1">MLSTTPNSGMRSPSTPRSGAASPRLSFDTELLRAYMKKLLQTTLQNATWPEPRERERVKAWMKEIGERVKERMIEIQPRGFKYIVMTQINENLGQGGRADMVCHWEDSDVVAREMFANNSLICICVAFAVRTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JIT9</accession>
    <name>A0A2H3JIT9_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WOLCODRAFT_66514</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH37658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JIT9"/>
    <dbReference type="STRING" id="742152.A0A2H3JIT9"/>
    <dbReference type="OMA" id="LDEYELW"/>
    <dbReference type="OrthoDB" id="422720at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030385">
        <property type="entry name" value="G_IRG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007743">
        <property type="entry name" value="Immunity-related_GTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14143">
        <property type="entry name" value="INTERFERON-INDUCIBLE GTPASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14143:SF1">
        <property type="entry name" value="IRG-TYPE G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05049">
        <property type="entry name" value="IIGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51716">
        <property type="entry name" value="G_IRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IRG-type G" evidence="4">
        <location>
            <begin position="96"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PCH37658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="318" mass="36585" checksum="61909BA34161BB73" modified="2018-01-31" version="1" fragment="single">QADEQRRLAEEQQRIAEEERRRAEEEKARADEDARRAREEREQAQREKEESDRKAAEAAAAREEAEENLRKGIRPIVIPTPEEYAETKRRLQYKEGLFHFAVAGVSGSGKSSLINALRGLRNKDRSAAPTGVTETTSVITRYPDPDPANPFVWYDVPGAGTLKIPDWIYFNAQGLYIFDCIIVLFDNRFTESDVAILRNCERFNITAYIVRSKSNQHIRNILADMGYESDEEDRTLKRTLIREAREKYVTETRASVARNLEEAGLPQQRVYIVAKDTMAKIVREEPAKDFLDELELLRDLLTEARARRSKQSGARRVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JIY2</accession>
    <name>A0A2H3JIY2_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WOLCODRAFT_137425</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD-104</strain>
        </source>
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        <property type="protein sequence ID" value="PCH40123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JJT7"/>
    <dbReference type="STRING" id="742152.A0A2H3JJT7"/>
    <dbReference type="OMA" id="NERICHR"/>
    <dbReference type="OrthoDB" id="408964at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345:SF91">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE PLK4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PCH40123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="163" mass="18174" checksum="8D769D880537E2B7" modified="2018-01-31" version="1" fragment="single">LTEAEVRGVVKSLVDALIYLRNERICHRDIKASNVLLTEDFRIKLSDFGLATRLPTPESTTQTFCGSPNYIAPEIVARVPYGFSVDVWSLGCLMLTCLSGIPAFEAPSVPDVFKKISRGEYFVPDNISFEAKDLIAGLLQSDPLHRIPLHRMLSHPFFKPSLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JK08</accession>
    <name>A0A2H3JK08_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_137951</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468124">
        <property type="protein sequence ID" value="PCH42526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JK08"/>
    <dbReference type="OrthoDB" id="2802763at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="407"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="475"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="491"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH42526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="600" mass="66250" checksum="835BEA5497B49644" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JKD4</accession>
    <name>A0A2H3JKD4_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="18">ATP-dependent peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">WOLCODRAFT_23151</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">MD-104</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the N-terminal section; belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH38198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JKD4"/>
    <dbReference type="STRING" id="742152.A0A2H3JKD4"/>
    <dbReference type="OMA" id="MSHFEWA"/>
    <dbReference type="OrthoDB" id="1413014at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141164">
        <property type="term" value="P:mitochondrial protein quality control"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19501">
        <property type="entry name" value="RecA-like_FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000001">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.760:FF:000002">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000175">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FTSH 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="entry name" value="Peptidase M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01458">
        <property type="entry name" value="FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005936">
        <property type="entry name" value="FtsH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01241">
        <property type="entry name" value="FtsH_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23076:SF97">
        <property type="entry name" value="ATP-DEPENDENT ZINC METALLOPROTEASE YME1L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23076">
        <property type="entry name" value="METALLOPROTEASE M41 FTSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
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    </dbReference>
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        <source>
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</entry>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
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                <person name="Barry K."/>
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                <person name="Martinez A.T."/>
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                <person name="Benoit I."/>
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            <strain evidence="1 2">MD-104</strain>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
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    </reference>
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    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
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            <dbReference type="EMBL" id="PCH39639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
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    </evidence>
    <sequence length="231" mass="26945" checksum="D6CFFC06FCDF77C3" modified="2018-01-31" version="1">MPCRNTEGKLHLSSLDINWDLLETFKGHLVRHIDRIRQFQEGLFVHEIRRFKNATWMDTSPCWINVGIDMCEKGPVIQWLAQAHQQILRFALPTADEQKVQKLSQSKSYMHVCRVCQLVDFAGFYCEPHSTGQEDKVVYISAYTTDKAVTYQLHPGAFRQHYASEPYPAKMKRLLAEVQLLSEIFKQCQDQPCTARVEVRIPLKLALPTFMDVLDGFMERSVMSIRPKIWW</sequence>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
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                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
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                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="18"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH41133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="112" mass="12484" checksum="3FE1F48240BC4499" modified="2018-01-31" version="1">MYSLGTVELVDPEVEVYDNENGYDDSRFDQRAETDDEGGSYAIGSDASSNSGFTLLEVIDTKLEWIFARSTVPLSTEELLRFPAGYRDFAWPLTVFSASIGWGLVLSHAKLY</sequence>
</entry>
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    <accession>A0A2H3JMP3</accession>
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        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
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        <lineage>
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            <taxon>Phaeolaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JMP3"/>
    <dbReference type="Proteomes" id="UP000218811">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH43462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="136" mass="15152" checksum="8350F9097C750CE4" modified="2018-01-31" version="1">MKLRLQDRQGRAAPGDAWISANELEISPLFYESDEDRNNGTNISIASTSSRQLCNERKRGQQSLLERSNTEYAPEATGVRIQYIRLRLAWHGCIRCLQGTSCRTFGDASVLMICDASPDTPGILSCIVNVTVFLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JMZ4</accession>
    <name>A0A2H3JMZ4_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
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    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_84904</name>
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    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Agaricomycetes</taxon>
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            <taxon>Phaeolaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467954">
        <property type="protein sequence ID" value="PCH39108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JMZ4"/>
    <dbReference type="OMA" id="NIRAECA"/>
    <dbReference type="OrthoDB" id="6511194at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35871:SF1">
        <property type="entry name" value="CXC1-LIKE CYSTEINE CLUSTER ASSOCIATED WITH KDZ TRANSPOSASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="81"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH39108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="270" mass="30718" checksum="F1011266835E5049" modified="2018-01-31" version="1" fragment="single">AARLIWKAGTNCHGWFGAEDLLKQVKIAIDLFEAKTNGWAVGLWIFDNAPSHQRRAADALSARRMPKGPKAGWTHRKDGPKMQIGTFPDGSSQALYFPDHHPVMPGWFKGMEQIIRERNLWPANGLKAQCDGFKCPSGQADCCCPRLLFTQPDFIDQKSQLEEYITSRGHLCDYYPKYHCELNFIEQYWGHAKMHYHTSPQTSDINEMEQIVLRCLDNVSLLYANRSARFISAYAQGLSGAEAVWANRKYHGHRTLPPALAAELKREARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JNC7</accession>
    <name>A0A2H3JNC7_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Alpha-ketoglutarate-dependent dioxygenase AlkB-like domain-containing protein</fullName>
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        <name evidence="2" type="ORF">WOLCODRAFT_136066</name>
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        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467942">
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    <dbReference type="STRING" id="742152.A0A2H3JNC7"/>
    <dbReference type="OMA" id="QEGHYDG"/>
    <dbReference type="OrthoDB" id="28127at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032870">
        <property type="entry name" value="ALKBH7-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21052:SF0">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21052">
        <property type="entry name" value="SPERMATOGENESIS ASSOCIATED 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-ketoglutarate-dependent dioxygenase AlkB-like" evidence="1">
        <location>
            <begin position="37"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH38144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="250" mass="28212" checksum="48BF23B1A144397B" modified="2018-01-31" version="1">MRSFSAIYKRNIASSFLRTHTRCGSSHVGVHALPQDLTFIPDFFSVSEQRILLTTALQKLNAAERRHFRQRRKQFCAKLKPTAASDSQETLHGIFLPDEYYDFQEGHYDGVIRRFREMHVSTWPSDFAGLSSIIERLQTLYPSHDTQTHILHLASDGEILPHIDNVGASGSWILGVSLGATRLLKLESLNDPNMQSELPLTSGSVYIQKDTLRYEYKHSILQNVFSSGGDGDLAQRLSVIVRDRLPSPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JNZ4</accession>
    <name>A0A2H3JNZ4_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_150574</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468053">
        <property type="protein sequence ID" value="PCH40519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JNZ4"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="244"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH40519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="344" mass="38519" checksum="9303C178D35EC304" modified="2018-01-31" version="1">MSDNQLMNTANRMIACAVAALRAAPESMEGEDYTQWQTKFMEELAFNMGNFPYKVFELGYRLPELYGSMVAEYTQVRNDGEEFNKIHVHEGDARIASIQNLAPTVDPTRPLPVVEDLGPNQWWTADNTLAEAEGSSTAQPATRKRGREDSEEESTEKEGGKDGGLGGDEEEGTGRGGSEDEEQGRESSREPRDSREQSREPRDSHEPSHEPRDRCERSRGPRDSHKKSRETRNSREPGRKSRDTTTSTTVVSQTWSKSGTRPPKRQRPIHRSPSTARQSSGSESDSLPPARHSRSKGSNKGKGKKASKASGLKVPKPRPKFSDEAKRSDSTNRMHYRHQYTGKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JPA3</accession>
    <name>A0A2H3JPA3_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Probable guanine deaminase</fullName>
            <ecNumber evidence="4">3.5.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Guanine aminohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WOLCODRAFT_22895</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>guanine + H2O + H(+) = xanthine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:14665"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16235"/>
            <dbReference type="ChEBI" id="CHEBI:17712"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; guanine degradation; xanthine from guanine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.3" evidence="4"/>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH37847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JPA3"/>
    <dbReference type="STRING" id="742152.A0A2H3JPA3"/>
    <dbReference type="OMA" id="HGVHLCD"/>
    <dbReference type="OrthoDB" id="194468at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008892">
        <property type="term" value="F:guanine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046098">
        <property type="term" value="P:guanine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000022">
        <property type="entry name" value="Guanine deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051607">
        <property type="entry name" value="Metallo-dep_hydrolases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11271">
        <property type="entry name" value="GUANINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11271:SF6">
        <property type="entry name" value="GUANINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="12">
        <location>
            <begin position="1"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00056079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00083147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PCH37847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="447" mass="47914" checksum="E2B2B94E42ACA0B5" modified="2018-01-31" version="1">MPGFIDTHTHAPQMPNIGSGQQYELLDWLAEVTFPMEARFADVNFAQQVYGSVVRRIIDCGTTTCCYYGTLHLDATKKLADIVYARGQRAFVGKCNMVRNSPEYYIEPSTEASLTATRELISYIRALPLNPRTREPLVRPILTPRFALSCTHELLSSLGSLARANLGLAIQTHVSENASEIAFTKRSFPAASLPAPPVQDAEGAAARETYAGVYDAFGLLRGNTVLAHAVHLENSEVELIKARGAGISHCPTSNFNLRSGCAKVGMLLDRGVKVGLGTDVSGGFSPSILRTVQDASVCSKVVAFQHQPSKDELDPDVSAQNDAQTQHRFANRQLPVATLLHLATLGGAQVCNLAARVGSLAPGKAFDALVVSVRSDAGNPAVWGAELDAALGVGASGGETGMKGGRVRTATQELEGMLERFLFCGDDRNIRRVYVQGRLIGGKEFEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JPA4</accession>
    <name>A0A2H3JPA4_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_164874</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
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                <person name="Kallen N."/>
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                <person name="Ling A."/>
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                <person name="Morgenstern I."/>
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                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
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                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
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                <person name="Benoit I."/>
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                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
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                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
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</entry>
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            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
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                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
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                <person name="Benoit I."/>
                <person name="Boyd A."/>
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                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
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                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
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                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
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                <person name="Schmutz J."/>
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                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
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            <end position="175"/>
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    <feature type="domain" description="DNA polymerase alpha/delta/epsilon subunit B" evidence="11">
        <location>
            <begin position="398"/>
            <end position="477"/>
        </location>
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            <begin position="1"/>
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        <source>
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</entry>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
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                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
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                <person name="Lindquist E."/>
                <person name="Ling A."/>
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                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
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                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
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            <strain evidence="2 3">MD-104</strain>
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</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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            <dbReference type="DOI" id="10.1126/science.1221748"/>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="249" mass="28141" checksum="D4D40E2B123B0722" modified="2018-01-31" version="1">MITLYDIPSDIKGIAWSPNTWKTRIALQIKGLQFETVWVEYPDIADLCKKIGAAPSGTRADGSPSYTLPVIHDSSTNTVVSESGLIARYLDKTYPNTPILISPETDALHGAFQEVSRFIILPHMSQLMVPPSHAHLHPPSQAYFRRTREISFGQKIEEISPPGAIREALLEKLQGGFTKLAEWLELDGREKLFFTGNRVSHADLSIAGWLIWIKLILGADSPEWLAVKTWNGGRWGRFMEHFEQYEKVW</sequence>
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            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Martinez A.T."/>
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                <person name="Hori C."/>
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                <person name="Kallen N."/>
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            <dbReference type="DOI" id="10.1126/science.1221748"/>
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            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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    <sequence length="264" mass="29373" checksum="ADFFBAABF360D269" modified="2018-01-31" version="1">MKKHPRDPRRISAEERIRVVREMCLERRRPVSVTELIEQSIPLTFRPRKPVSHEDANKLLAILLSPADSARSENSVNHQVMATPSSSNDPSSGRTCNTNEHEDDTACTMELGSPLLPSILTARPGTRGIYTSRNDKCTGLTGATSTLQPQQRPSICIRSVKSVVRDHDSARVAHCTDTKAAPPAEEWRVATEAHHGPQRSRTIYMTRNARASVEQIEQQPRLPRGILKGIIDDVLEVEDIIDPHVESTTMQLMTFACATAFGRK</sequence>
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            <strain evidence="2 3">MD-104</strain>
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    </evidence>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
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                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
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                <person name="Gaskell J."/>
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                <person name="Gorecki P."/>
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                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
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                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
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                <person name="Sabat G."/>
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                <person name="Sun S."/>
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                <person name="Wiebenga A."/>
                <person name="Young D."/>
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                <person name="Eastwood D.C."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">MD-104</strain>
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                <person name="Kallen N."/>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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                <person name="Benoit I."/>
                <person name="Boyd A."/>
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                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
    </evidence>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH41058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JTA7"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH41058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="112" mass="12954" checksum="F5D85679E45E6B55" modified="2018-01-31" version="1">MPSLVRPTLGSRPLSLVSRLLPYRYRDCLCVVRVRPDAAPAVCASLRPMLALYTRAASRRGDYYKLNARSHVEYIACRRRFAESKRKSIVPYPVQHERSSRRVEAFREESCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JU47</accession>
    <name>A0A2H3JU47_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">26S proteasome regulatory subunit 6A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WOLCODRAFT_116928</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468053">
        <property type="protein sequence ID" value="PCH40234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JU47"/>
    <dbReference type="STRING" id="742152.A0A2H3JU47"/>
    <dbReference type="OMA" id="NKISHEH"/>
    <dbReference type="OrthoDB" id="9443236at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000009">
        <property type="entry name" value="26S protease regulatory subunit 6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000076">
        <property type="entry name" value="26S protease regulatory subunit 6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000037">
        <property type="entry name" value="26S protease regulatory subunit 6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 13" id="KW-0647">Proteasome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="12">
        <location>
            <begin position="240"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="23"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00069320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PCH40234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="460" mass="50907" checksum="D5397ECABA1CA877" modified="2018-01-31" version="1">MSSAQPPNQPPADDNAVAEKPEASSSTAPASAPEAMDTEPDQPPEETWADIPEDIMALSTDEIFTRIRLIDNDLKVMRSETQRLQHEQNVMKEKIRDNAEKIKQNKVLPYLVGNIVEILEVDPEVEEDGANRDLDSMRKGKCAVIKTSTRQTVFLPLIGLVPAEKLKPQDLVGVNKDSFLVLDTLPAEFDSRVKAMEVDERPTETYTDIGGLEKQIEELVEAIVLPMEQADKFKALGIKPPKGCLMYGPPGTGKTLMARACAAQTKACYLKLAGPSLVQMFIGDGAKLVRDAFALAKEKAPTVIFIDELDAIGTKRFDSEKSGDREVQRTMLELLNQLDGFSSDDRIKVIAATNRIDILDPALLRSGRLDRKIEFPLPNETSRARILEIHSRKMTCSPDVNYEEIARSTDEFNGAQLKAVCVEAGMIALREGATKLSHEHFLGGIAEVQSKKKNDLVYFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JZH1</accession>
    <name>A0A2H3JZH1_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="8">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WOLCODRAFT_138921</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7 8">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 8">Belongs to the peptidase C12 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="8"/>
    <dbReference type="EMBL" id="KB468157">
        <property type="protein sequence ID" value="PCH44289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JZH1"/>
    <dbReference type="STRING" id="742152.A0A2H3JZH1"/>
    <dbReference type="OMA" id="TCFVQAP"/>
    <dbReference type="OrthoDB" id="427186at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR001578">
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    </dbReference>
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        <property type="entry name" value="Peptidase_C12_UCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057254">
        <property type="entry name" value="UCH_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589:SF17">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01088">
        <property type="entry name" value="Peptidase_C12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00707">
        <property type="entry name" value="UBCTHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00140">
        <property type="entry name" value="UCH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52048">
        <property type="entry name" value="UCH_DOMAIN"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="6 7 8" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4 7 8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UCH catalytic" evidence="9">
        <location>
            <begin position="10"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <feature type="site" description="Important for enzyme activity" evidence="7">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PCH44289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="246" mass="26769" checksum="E0F4C413C2B99D74" modified="2018-01-31" version="1">MASDESAVSRWVPLESNPDVLNEWASKAGLVESQAHFEDVYGLDPELLAMVPQPVKAVILLFPITDVIDAKAKQEDERIRREGQHPIDPTVFYLKQTIGNACGTVGLLHALANSNVTFAPESPLALFIEECKDKTPEERAQILETTPLFANIHADAASSGQTAAPDPNANTELHFTCFVQAPNPPRSDVASPDPMRLLELDGRRVGPVDRGASTNLLEDVAKFVKEQYVSQTASMHFSMIALVPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JZH4</accession>
    <name>A0A2H3JZH4_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_137467</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="2780340at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH41557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="123" mass="12705" checksum="673DB435012982B5" modified="2018-01-31" version="1">MSQASPCSSPSPPRSQVHFDTRPGIGRGLGTRANTYSAAHNAAAMSSSTTMPVLPRNVSDVGAASGGFLSRMFGSTNKGHEKDREGAEGAETTETHGVGSAFRRLAHSKSALFRSQASQAQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-09-13" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K067</accession>
    <name>A0A2H3K067_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_151864</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH41817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K067"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH41817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="304" mass="34223" checksum="E85D42EC837A852D" modified="2018-01-31" version="1">MFAGGQLPCLSDLRIWGGEWTPGAMPQNVFLHLSSFHSITSLLLCDITLPSIAVVLRLVCAFDRLESLQINYLRWLDRRAPPTSRRWAPSPTLRKVGFLDLDWPDELGTLHPYGELETSSGSDIILLLSNALSCSDLKQLLHHPGKALCRFGICPLEPLQGMDPNSIQPLRVPDVDLSRNAGLQVLEMIIEEYNIPSALLERAETYGVIQRMISSAYPAVLEEITIRVKLEQNCPLILSHVLLALRGAVCPPDQPLAPERYTSLKSMKLEIHYVDVNCKRQMEADWDRLAPIWFPSFYSRGIIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K0A8</accession>
    <name>A0A2H3K0A8_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WOLCODRAFT_120564</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB468124">
        <property type="protein sequence ID" value="PCH42434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K0A8"/>
    <dbReference type="STRING" id="742152.A0A2H3K0A8"/>
    <dbReference type="OMA" id="RCKGLKV"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF19">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="122"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="26"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="190"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="262"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
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            <end position="885"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
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        </location>
    </feature>
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        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
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        <location>
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            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="836"/>
            <end position="845"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PCH42434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="979" mass="108578" checksum="934CC7E32E422180" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K488</accession>
    <name>A0A2H3K488_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_91093</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="PCH44988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH44988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="338" mass="38865" checksum="7A42F0AF86319D1E" modified="2018-01-31" version="1">MSELARLVDVFASGQHTIYDRICERLTPVSLIRMRRVSRTTYQAVQDFSYRAFDVNRRLSRFFSDPFAFRSLQARTATLISGSFALQFFDRTFYPEADLDLVAAVYTFVRPSDDNESQKVKLQVIVPTVSPFECVITFHSTCVMNAISYNAAYSLYPYATFEQRQSLATNPKDRKRAAFRKYAARGWKILSSLSPLLVPSALSDRFFVDQSRGVVDKHSWVMPLNTDGVTGPEPLSPSSTPLTWDPVAECSWVLRSIRGEILEAHMTYFITSSRILKYRYTAADEDCDIYDGYRGMLIRFLTSQERLETRKLHSTGEQPGGEIWTWYVPISRHLRMTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K4M7</accession>
    <name>A0A2H3K4M7_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATP synthase subunit delta, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">F-ATPase delta subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">WOLCODRAFT_164398</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase epsilon chain family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468146">
        <property type="protein sequence ID" value="PCH43387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K4M7"/>
    <dbReference type="STRING" id="742152.A0A2H3K4M7"/>
    <dbReference type="OMA" id="GWVSAIW"/>
    <dbReference type="OrthoDB" id="2261329at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12152">
        <property type="entry name" value="F1-ATPase_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.15.10:FF:000003">
        <property type="entry name" value="ATP synthase subunit delta, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.15.10">
        <property type="entry name" value="F0F1 ATP synthase delta/epsilon subunit, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00530">
        <property type="entry name" value="ATP_synth_epsil_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001469">
        <property type="entry name" value="ATP_synth_F1_dsu/esu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020546">
        <property type="entry name" value="ATP_synth_F1_dsu/esu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036771">
        <property type="entry name" value="ATPsynth_dsu/esu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13822">
        <property type="entry name" value="ATP SYNTHASE DELTA/EPSILON CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13822:SF7">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT DELTA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02823">
        <property type="entry name" value="ATP-synt_DE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51344">
        <property type="entry name" value="Epsilon subunit of F1F0-ATP synthase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="11" id="KW-0139">CF(1)</keyword>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PH" evidence="16">
        <location>
            <begin position="241"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="16"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="179"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="395"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="611"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="1007"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
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                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
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                <person name="Larrondo L.F."/>
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                <person name="Lucas S."/>
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                <person name="Morin E."/>
                <person name="Murat C."/>
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                <person name="Ohm R.A."/>
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                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
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                <person name="Eastwood D.C."/>
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            <dbReference type="DOI" id="10.1126/science.1221748"/>
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</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Barry K."/>
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                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
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                <person name="Benoit I."/>
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                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
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                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
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                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
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                <person name="Lundell T."/>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
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                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
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                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
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                <person name="Benoit I."/>
                <person name="Boyd A."/>
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                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
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                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
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                <person name="Murat C."/>
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    </evidence>
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    </evidence>
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    </evidence>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD-104</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH33711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3IVG4"/>
    <dbReference type="STRING" id="742152.A0A2H3IVG4"/>
    <dbReference type="OMA" id="SKGCWEV"/>
    <dbReference type="OrthoDB" id="1621027at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047545">
        <property type="term" value="F:(S)-2-hydroxyglutarate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004617">
        <property type="term" value="F:phosphoglycerate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12176">
        <property type="entry name" value="PGDH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000041">
        <property type="entry name" value="D-3-phosphoglycerate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050418">
        <property type="entry name" value="D-iso_2-hydroxyacid_DH_PdxB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008759">
        <property type="entry name" value="PRK11790.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43761:SF1">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE CATALYTIC DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43761">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G13630)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="6">
        <location>
            <begin position="27"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="7">
        <location>
            <begin position="131"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PCH33711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="432" mass="47077" checksum="7871E1EB7403FF4D" modified="2018-01-31" version="1">MSLSPVASTVRIPKVLHPVDNEHLKLLLLENISQGAVKAFEAQGFHVDHSTKAMSEDELVEKIGSYHAIGIRSKTRITERVIKAATKLLVIGCFCIGTNQVDLITAAKAGIPVFNSPFSNSRSVAELVISEVIALSRQYFQRAFEMRQGIWNKQSKGCWEVRGKTLGIVGYGHIGSQLSVLAEALGMRVLFCDVISIMPLGSARQVDTMEALLNESDFVTLHVPELPETMNMISTEQLSAMKKGAYLLNNARGKVVDIPALIEALQSGHLAGCAIDVYPAEPGSNGAPFDDQLNSWSSTLRSLPNVILTPHIGGSTEEAQRMIGEEVSAALTRYLTYGSTVGSVNFPEVDLRPITAEQQGIRLCHVHNNIPGVLRQVNEILSPYNVEKQYSDSKGDTAYLMADIADVSPTDVNRLRELISQTSANILTRLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IW55</accession>
    <name>A0A2H3IW55_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Family A1 protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WOLCODRAFT_22529</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH34196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3IW55"/>
    <dbReference type="STRING" id="742152.A0A2H3IW55"/>
    <dbReference type="OMA" id="NQAVDYT"/>
    <dbReference type="OrthoDB" id="660550at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013809969" evidence="6">
        <location>
            <begin position="20"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="7">
        <location>
            <begin position="81"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PCH34196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="406" mass="42637" checksum="47176E4DED25BD55" modified="2018-01-31" version="1">MALGSSLLATLILALAVAAKPVEIVDNLVHLPLVKRTNAANITNVLQRDQARAQALKNPKSQAHKRRASGSISATNQAEDYVVEVGIGSSGTTYTLLVDTGSSNTWVGAGKSFESSSTTVDTGDSVSVSYGSGSFSGTEYEDTVTLGSLTIQKQSFGVASQAEGFSGVDGIIGIGPVDLTEDTVNGVDEVPTVTDNLYSQGQISENLVSVYFAPTTSEDDTNGELTFGGTDSSKYTGSINYVDTTSTSPASYYWGIDESITYGSSGETILSSTAGIVDTGTTLVLIATNAYSKYQSVTGATEDESTGLLRLSSSQYDNLESLYFNIGSESYELTPNAQIWPRSLNSAIGGSSDDIYLIVNSIGTPSGEGLDFINGYTFLERYYSVFDTGNSRVGFATTSYTDATSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IWL7</accession>
    <name>A0A2H3IWL7_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_160843</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH34390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3IWL7"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH34390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="341" mass="36520" checksum="23094B23BF81C340" modified="2018-01-31" version="1">MSSPLMILDFSSSGLQGWTQRFSVDPEEAMRRPRLYTHQHPGRPHIMKGFGLSQADKDVGSRLVWQGNGAVPSEQKASCSPSETVDVEKDDDAIYRGRGNGGAVPPITASGGPSSIFFLTHPRHRQGETAAKPQPTPLLTCQSPFDPTGLLEAPGGSRCSVAASRTACAGTSRRCATYDSFTTPRAATDVAPYVGGPLLATRARSISCRRVELQIQFYDNAQRWKYGKNTRVAGAVLTAGCAGRVARRCRAPRRTGWKKGAWRGVARPAKDDIEGCNDGATKTGEGERARAEQCEAITTSGVFHEAGCRSAIVLFRGPRASGLRKQLGLQTQYGGGGDDQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IXL3</accession>
    <name>A0A2H3IXL3_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_160671</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH34185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3IXL3"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH34185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="130" mass="14331" checksum="59BB18AC4CEB6E40" modified="2018-01-31" version="1">MPGLRGHFLRGSVTTKVAETDTYWALPASHAISVKTSAIGGRRRAPGAADSEQAQHDRIRVQRGLVVPFPPVPRWPSVCLPGQTPLTGSADPHPRDRELSRKRHVADDVPKHACRAQGARRKGARRKRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IYU9</accession>
    <name>A0A2H3IYU9_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Iron uptake cluster protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_91329</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467832">
        <property type="protein sequence ID" value="PCH34901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3IYU9"/>
    <dbReference type="STRING" id="742152.A0A2H3IYU9"/>
    <dbReference type="OMA" id="DRNSHAN"/>
    <dbReference type="OrthoDB" id="202203at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004174">
        <property type="term" value="F:electron-transferring-flavoprotein dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735:SF2">
        <property type="entry name" value="FE-REGULATED PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="2">
        <location>
            <begin position="4"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH34901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="469" mass="50641" checksum="39463479DB9ABBB4" modified="2018-01-31" version="1">MSKTVAVLGASYGGAHAAKLLAQGLPAGWKVVVVDRNTHMNHLYVLPRYAVVSGHEYKAFIPYGPLLRGATASKPDASVVFLHANVTSLSPRSITLSRAFPEHGVDDTTHTLRFDYAVYALGSHLPAPIDLWGPVGDEQDVAALTVGADHESTADKANASHSSSNPLERAAITRGTKPEGIEWLKRFRRRVEKASSVLVVGGGALGVQYATDIAEVYPHKRVTLLHSRKQLMPRFSERLHSEIVSSLSELKITTILGDRLDLSSIKAGKTTQGPDGKEERVVRTLSGHEISAELILLCTGQNLNTDLVAQAIPDAVIPDGSKKGLIRVKRTMQVAVPSNPAAPDMPVDSAKGSGDEHLHVPHPHLFAIGDAADAFGAMNSGRSSYFQLINRSEILRTHGKAEGQADSSSDDLEQYTPGPPMIKITLGLTKQLYEVDGEVGTKMDGTPDLEAHRMWEFYGVETDGDKMYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IYZ8</accession>
    <name>A0A2H3IYZ8_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine/threonine-protein kinase</fullName>
            <ecNumber evidence="8">2.7.11.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WOLCODRAFT_139656</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.21"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.21" evidence="8"/>
    <dbReference type="EMBL" id="KB467843">
        <property type="protein sequence ID" value="PCH34951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3IYZ8"/>
    <dbReference type="STRING" id="742152.A0A2H3IYZ8"/>
    <dbReference type="OMA" id="IQIHKSM"/>
    <dbReference type="OrthoDB" id="408964at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13118">
        <property type="entry name" value="POLO_box_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13117">
        <property type="entry name" value="POLO_box_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14099">
        <property type="entry name" value="STKc_PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000647">
        <property type="entry name" value="Serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.30">
        <property type="entry name" value="POLO box domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033701">
        <property type="entry name" value="POLO_box_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033695">
        <property type="entry name" value="POLO_box_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000959">
        <property type="entry name" value="POLO_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036947">
        <property type="entry name" value="POLO_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345:SF0">
        <property type="entry name" value="CELL CYCLE SERINE_THREONINE-PROTEIN KINASE CDC5_MSD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00659">
        <property type="entry name" value="POLO_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82615">
        <property type="entry name" value="Polo-box domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50078">
        <property type="entry name" value="POLO_BOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="1"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="POLO box" evidence="11">
        <location>
            <begin position="524"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="domain" description="POLO box" evidence="11">
        <location>
            <begin position="628"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="381"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="725"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="402"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="452"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="470"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="740"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PCH34951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="754" mass="84679" checksum="AD547F679FC56279" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IZS9</accession>
    <name>A0A2H3IZS9_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WOLCODRAFT_53771</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467854">
        <property type="protein sequence ID" value="PCH35436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3IZS9"/>
    <dbReference type="STRING" id="742152.A0A2H3IZS9"/>
    <dbReference type="OMA" id="GHEIADC"/>
    <dbReference type="OrthoDB" id="3049716at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="9"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PCH35436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="210" mass="21876" checksum="23D0C07096AE77F1" modified="2018-01-31" version="1" fragment="single">SSAPAKAMCTNCRHSGHLTKDCFQPGGAMEGRRDEVLAAKCAKCDQNRPHAAAVPKTYTDAQGCAFIVDTSGSVVYLAVEVSAASPGVSELTGVAVDVDPAWLNSVCSPADDLEYVTLLSEDASVSLDWGTHSQASVDPSAYAVTPVVASSCRVPTVGSTPSYFDSGASTHLSPSWSDFSKLHPIAPRGIRGINRSVIHAHGIGHIRLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J0U8</accession>
    <name>A0A2H3J0U8_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_145870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
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    <sequence length="278" mass="29602" checksum="3A2FE8E5892FDA8C" modified="2018-01-31" version="1">MSTADSQSAADPSLLLSVWPALLKTLFSSILIFGALLLFTFLPQMAILVLVSGPLVPILAPILALLAPILILLAPTLALLAPILALLASILALLAPILTLLLISAETVLIFSFFAYPLLLAPALAHVFDATLRARGQGELVESGLTLTRNPGAEGALLEPFQALSGGGPLRYLARLSLNFVPLLGLAAFVLYNGYQSGPSWHARYFQLKGCSEAQQRAFVDERRAEYAAFGIVSLLFTLIPLVGPVFIFTNTVGAAMWAAQLEAQANLLQPPESDNEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J2I7</accession>
    <name>A0A2H3J2I7_WOLCO</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="1" type="ORF">WOLCODRAFT_127202</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
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                <person name="Lundell T."/>
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                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
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                <person name="St John F."/>
                <person name="Stenlid J."/>
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                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467876">
        <property type="protein sequence ID" value="PCH36442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J2I7"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH36442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="128" mass="14766" checksum="8CBE2CD1B3E4087B" modified="2018-01-31" version="1">MTMPVGQSREVQYIKSSYYIPFPSYHIRLRNTRLPTCARDVQARASSSTANPCSNIGFNAWLHHVLGIQALDRYMVSVIQPQDWYTIRYGRSGVESTGYPPDWRRFIDGTCLTDHGMIIKRPCRILLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J381</accession>
    <name>A0A2H3J381_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467887">
        <property type="protein sequence ID" value="PCH36692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J381"/>
    <dbReference type="STRING" id="742152.A0A2H3J381"/>
    <dbReference type="OMA" id="ITMEIAG"/>
    <dbReference type="OrthoDB" id="3147752at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH36692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="393" mass="43927" checksum="42C8489016118574" modified="2018-01-31" version="1">MVEILEEELRETKEQLKEIKQKLRSTDAELRKAADINGILQDQVANERNARDREYQRHRQVVKEHSRTLAKMNEKHENVVDLLETRSAELRVAQTYLTKADNLSDADILRMFEALNSHIYQLSAHLADNIQLDRGSLSTPQTWITEATEILDGVVGAELIQLLAKSPHSELPVCIQFALQSRMVGFANMVISTWNFHDLEHNKLYNDVYMQLRASEDPAVSGRWRALTVTSLRALTLNETTIPRLHDHLAIFITSITLLAGLTAAPVQAHQQIISRYGGELITLVDIMLQLQRAIGEEIISSQINLVVYLSGETFNPEHMEDYNAGGRPCTPRESDARAPVVVLGTMSLGVTRIEKKAMGGNAAGQGTWVSVTLLKPKVVLNTILDELQISGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J3N3</accession>
    <name>A0A2H3J3N3_WOLCO</name>
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        <submittedName>
            <fullName evidence="5">RIC1-domain-containing protein</fullName>
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        <lineage>
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    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB467831">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034066">
        <property type="term" value="C:Ric1-Rgp1 guanyl-nucleotide exchange factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="project" value="InterPro"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040096">
        <property type="entry name" value="Ric1"/>
    </dbReference>
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        <property type="entry name" value="RIC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22746:SF10">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR SUBUNIT RIC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22746">
        <property type="entry name" value="RAB6A-GEF COMPLEX PARTNER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25440">
        <property type="entry name" value="Beta-prop_RIC1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07064">
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RIC1 C-terminal alpha solenoid region" evidence="4">
        <location>
            <begin position="805"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="227"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PCH33349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="1001" mass="111687" checksum="C26003367C5C5C6F" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J5Z0</accession>
    <name>A0A2H3J5Z0_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.13</ecNumber>
        </recommendedName>
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        <name evidence="17" type="ORF">WOLCODRAFT_60957</name>
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    <organism evidence="17 18">
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        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">ATP-dependent RNA helicase required for 60S ribosomal subunit synthesis. Involved in efficient pre-rRNA processing, predominantly at site A3, which is necessary for the normal formation of 25S and 5.8S rRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="3"/>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH33058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J5Z0"/>
    <dbReference type="STRING" id="742152.A0A2H3J5Z0"/>
    <dbReference type="OMA" id="KKTHDMY"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00268">
        <property type="entry name" value="DEADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044742">
        <property type="entry name" value="DEAD/DEAH_RhlB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 13" id="KW-0347">Helicase</keyword>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="16">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="41"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="244"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="12">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PCH33058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="442" mass="47574" checksum="9611AE86E1E3B9CC" modified="2018-01-31" version="1">MPKGVSPVTPVLSFDQLDVPSELHSAFEGFKEPTPIQACSWPPALAGRDVVGIAETGSGKTLAFGLPALARLITSPPKDSKKSKGTTTVTTLVLAPTRELAIQTHDTLSALGAPHGIASVAVFGGVDKGPQIKTLKNANKDGKTTQIIVGTPGRILDLVNDGACDLSRVTYLVLDEADRMLDKGFENDIRSIIGHTKQGAERQTLMFSATWPEAVRRLAGSFQRDPVRVTVGSDDLTANSRVEQIVEVFDDTRSKDSRLLGHLRSHSHKKAGSAADARILVFVLYKKEAARVEDMLRNKGYSVGGLHGDMSQTARMDALQNFKTGATGLLVATDVAARGLDIPNVAVVINYTFPLTIEDYIHRIGRTGRGGKSGKSITFFTGDKHERALAGELARVLRESGFEAEGLKKFPMTIKKKTHSAYGAFFRDDIPTPSGPTKITFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J6G2</accession>
    <name>A0A2H3J6G2_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glutamate--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Glutamyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">WOLCODRAFT_22873</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Glu) + L-glutamate + ATP = L-glutamyl-tRNA(Glu) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9663"/>
            <dbReference type="Rhea" id="RHEA-COMP:9680"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.17" evidence="3"/>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH37806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J6G2"/>
    <dbReference type="STRING" id="742152.A0A2H3J6G2"/>
    <dbReference type="OMA" id="FIHIPDG"/>
    <dbReference type="OrthoDB" id="10250478at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017102">
        <property type="term" value="C:methionyl glutamyl tRNA synthetase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004818">
        <property type="term" value="F:glutamate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00807">
        <property type="entry name" value="GlnRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000070">
        <property type="entry name" value="Bifunctional glutamate/proline--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1160.10:FF:000001">
        <property type="entry name" value="Glutamine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.800.10:FF:000001">
        <property type="entry name" value="Glutamine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.240.10:FF:000004">
        <property type="entry name" value="Glutamyl-tRNA synthetase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1160.10">
        <property type="entry name" value="Glutamyl-trna Synthetase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.800.10">
        <property type="entry name" value="Glutamyl-tRNA Synthetase, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="entry name" value="Ribosomal Protein L25, Chain P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02076">
        <property type="entry name" value="Glu_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050132">
        <property type="entry name" value="Gln/Glu-tRNA_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004526">
        <property type="entry name" value="Glu-tRNA-synth_arc/euk"/>
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                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD-104</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH33468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J748"/>
    <dbReference type="STRING" id="742152.A0A2H3J748"/>
    <dbReference type="OMA" id="VKHERIN"/>
    <dbReference type="OrthoDB" id="2094832at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051654">
        <property type="entry name" value="Meroterpenoid_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35897">
        <property type="entry name" value="METHYLTRANSFERASE AUSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35897:SF1">
        <property type="entry name" value="METHYLTRANSFERASE AUSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PCH33468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="325" mass="36526" checksum="9E1F3ECD733098B9" modified="2018-01-31" version="1">MSRSWKYPAFLTHNDLTDPRPARHERSGEAPLDQNAAIPSDQFYSLTGDELAFFKSQTGIQDEAELKKHIIQVKEEALVVQPYRCISYFSFTKLFISRLPAYSQLLKLGKERQSPIFLDIGCCFGNDLRKAVADGFPAERAIGSDIHLEFWHLGNKLFKTSKETFPAHFIPGDALNPEFLKPVPPFKSLPTGSVPDLSTLRTLTPLQGRISAIHASAFFHVFEEAGQLQLAKSLAGLLSPEPGSVIFGAHAGLPEKGFRQRSRIADTGPLMFCHSPESWIQLWDGEIFEKFTVKVEAVLVEVKHERINFLEGGVWYQLVWSVTRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J7I3</accession>
    <name>A0A2H3J7I3_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Hydrophobin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WOLCODRAFT_165744</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Secreted</location>
            <location evidence="1 7">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the fungal hydrophobin family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467832">
        <property type="protein sequence ID" value="PCH34689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J7I3"/>
    <dbReference type="OrthoDB" id="4225815at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005199">
        <property type="term" value="F:structural constituent of cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23507">
        <property type="entry name" value="hydrophobin_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001338">
        <property type="entry name" value="Class_I_Hydrophobin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019778">
        <property type="entry name" value="Class_I_Hydrophobin_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01185">
        <property type="entry name" value="Hydrophobin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00075">
        <property type="entry name" value="HYDRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00956">
        <property type="entry name" value="HYDROPHOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0134">Cell wall</keyword>
    <keyword evidence="6 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013984223" description="Hydrophobin" evidence="7">
        <location>
            <begin position="21"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PCH34689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="118" mass="12191" checksum="7822B8C3B1D2A4E4" modified="2018-01-31" version="1">MFRNVLLVLALSIQMLVVMSDACLTHHTTRGMSQCLGTVQCCEGETFSKDSEGAYALMQVLGISVDALSKKVLATGCSSSGIGILNGNTCKSSPMCCDDNSFGGLVGIGCNDIGSTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J7P6</accession>
    <name>A0A2H3J7P6_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ARM repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_130785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH38246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J7P6"/>
    <dbReference type="STRING" id="742152.A0A2H3J7P6"/>
    <dbReference type="OMA" id="PRRALDM"/>
    <dbReference type="OrthoDB" id="26149at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040144">
        <property type="entry name" value="RAP1GDS1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10957">
        <property type="entry name" value="RAP1 GTPASE-GDP DISSOCIATION STIMULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="645"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="649"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH38246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="753" mass="80961" checksum="747F859E8937FA35" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J7Z5</accession>
    <name>A0A2H3J7Z5_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">TrkH-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
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                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
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                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
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                <person name="Martin R."/>
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                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
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        </source>
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                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
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                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
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                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">MD-104</strain>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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    </evidence>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
    <sequence length="372" mass="38700" checksum="3722BFD9F19B436F" modified="2018-01-31" version="1">MAHTYIFHFFLFEPPVSVRFHTALVGWLRSPSGGLCSHLLSCTACGVRRRRSYLLSRASPCGVGVARSRSGPVPWCLVAQSPVPCCAPWSSLAEYPVRHSLWYSLAISGGAGRSLAQPGEAGPNVRASKQFLPRGYTLRPFLLFASLTIPPCSLLFMLDAPPPALLPCHLCINLAAHQVDAAPAPTRDAADAPHIPAPAAPVLPPVPVGDAARAAAGAAPPLAEQVPAPVAPSPPAARPAALPPLVGEPPAHALGPLAPPVTNLFASPEELAAVRAAALSSADDGKVTPIPPIRKGYKGSPLELGEFPIHYLAMGPPMALLILAGTCAPPSLLVFGLTCLHARRSRRVLHLAAAGRAGVAHLRPTHAIHVFA</sequence>
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        <name evidence="5" type="ORF">WOLCODRAFT_149701</name>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
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                <person name="Wiebenga A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5 6">MD-104</strain>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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</entry>
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            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Ferreira P."/>
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                <person name="Glotzer D."/>
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                <person name="Heitman J."/>
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                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
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                <person name="Ruiz-Duenas F.J."/>
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                <person name="Stenlid J."/>
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                <person name="Wiebenga A."/>
                <person name="Young D."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH38920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="204" mass="23044" checksum="5C1992F9153862AA" modified="2018-01-31" version="1">MSRLPEGFQRPVPLHEETGWIAGACSDRKFPHRNWSHKNVQQVFESADICIIAFVHHPPAEGDADAVESATWRISWMRTSHIMGLFGITHFLGSKTASLELHPRELAWHIALLPLPPSRQFSMFSESPKWAMVGGAVRIEYKYAINTSRELAALMNQHSHATWWLTDIPNPASVDSPDCVPVQSSAPWGQGSRVPFWVGQRHYE</sequence>
</entry>
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    <accession>A0A2H3JAT6</accession>
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            <fullName evidence="3">Ty3 transposon capsid-like protein domain-containing protein</fullName>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
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                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
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                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <dbReference type="DOI" id="10.1126/science.1221748"/>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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        <location>
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            <position position="452"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH38745.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="529" mass="59368" checksum="B83EEE23D6BA23D9" modified="2018-01-31" version="1"> </sequence>
</entry>
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    <accession>A0A2H3JBT8</accession>
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        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
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            <taxon>Phaeolaceae</taxon>
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        </lineage>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
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                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JBT8"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH39710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="188" mass="22077" checksum="F1F204F2887279CF" modified="2018-01-31" version="1">MLLSEDAAQKAYFVRITAKYHHDHPTPLPPALLADRILSAETVAKIVDKVRIEPEWVKDHFHLLPEGIERCHIWAMYKKYQWALHLLLIFEEADWLLCQLHNIIFKDYKFSAKKDSQTVVNQVRNFRRFYDAFFEAILYDDITNKELRESERDANAIRKYLRHGKVLDGSVRSAVCGLAALKYTFPTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JC20</accession>
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        <submittedName>
            <fullName evidence="8">DUF590-domain-containing protein</fullName>
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        <name evidence="8" type="ORF">WOLCODRAFT_28440</name>
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        <lineage>
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            <taxon>Phaeolaceae</taxon>
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    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Anoctamin"/>
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    </dbReference>
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        <property type="entry name" value="Anoctamin_TM"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Anoctamin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="177"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="210"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="292"/>
        </location>
    </feature>
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        <location>
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            <end position="321"/>
        </location>
    </feature>
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        <location>
            <begin position="662"/>
            <end position="684"/>
        </location>
    </feature>
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        <location>
            <begin position="4"/>
            <end position="137"/>
        </location>
    </feature>
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        <location>
            <begin position="169"/>
            <end position="690"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF04547"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF20877"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH36279.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="759" mass="85909" checksum="39E25A153383FE87" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JCX9</accession>
    <name>A0A2H3JCX9_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
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        <name evidence="4" type="ORF">WOLCODRAFT_95588</name>
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        <name type="common">Brown rot fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family.</text>
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        <property type="protein sequence ID" value="PCH37663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="742152.A0A2H3JCX9"/>
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    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="G_IRG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007743">
        <property type="entry name" value="Immunity-related_GTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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            <begin position="277"/>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51716"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="287" mass="32259" checksum="D3C6CC644F842350" modified="2018-01-31" version="1">MEADRHATEATSALDEAQRQLREGVRPITIPTREEMEATKRRLQYKEGIFHFAVAGVSGSGKSSLINAFRGLRNRDHGAAPTGIVETTGEITRYPDPDPVNPWAWYDVPGAGTIRIPDWVYFNAQGLYCFDCIILLFDNRFTETDIAILRNCARYNIPAYIVRSKSNQHIKNILYDMGYDSDRDETTGHALAQAARRRYIAETRASVARNLREAQLPQQRVYVVSKDTLVRIIRDGSANDPLDELELLRDLLTEARARRSRRPSLDIDGYVGGRPGSSSLPASSSVF</sequence>
</entry>
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        <name type="common">Brown rot fungus</name>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6 7">MD-104</strain>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH36759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="327" mass="36634" checksum="E236D91C93DB30F2" modified="2018-01-31" version="1">MDLRQTLMAIGRYWDIGRKWFVIMEPGGQGWGRTINVRLLNVYALGDRTPVIVLLYRALSDAQRWTSEEWAEAQADQNGQHEMATIKSTTLEQKLLLKVLSLNATYLPADYSPERGPTEDGFQVSLLLPVGPLSFGDVGKLNRDLGCAVCGKKSDNRCARCKSVSYCGDECQRADWSDHKQSCRSIVGGTWRTVPFAAMAPGTEGMCMSVMNRLTTTGHTRTIPVSTPSDRAAPPKNVHGSNVFLVKIQVALMTGRPQEMMVYDRQKSVHVFFTALGAPAYFEELLAEMRGPRGGYDGLKMYRWARRVSDWELSVCVDKEPQTEIKW</sequence>
</entry>
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    <accession>A0A2H3JDV8</accession>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
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                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
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                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
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                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
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                <person name="St John F."/>
                <person name="Stenlid J."/>
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                <person name="Wiebenga A."/>
                <person name="Young D."/>
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                <person name="Martin F."/>
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                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH36919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="394" mass="43252" checksum="DA5BF42EA1BA14C8" modified="2018-01-31" version="1">MPQQFQNMPQASGVAYRVDSDLSAGGKSSQTTRNRQARKRPRSSSASRAERMISMPPLQQPTHSSDQLPISSTQSLSNMHTLRLRGGRSLPTHSMTDAMARNEPVGGEMLMCTADTDTGLRLKVAISYAQQQHKEAPWYFPWMHILQRQLSFELSTGTSTSVIALPFPQLPVDAEVDTYENPWDWTVDQAAGNQLGATVAVYESGGSDEDSEEDLAGNLEEYLAATVDDLNGAMRQSLSPDPLALDCLPDDLRENIGRCIHNRQTSSLSPGILHSNKRQSLSPDPLLLGCRPDSIQQLSSLGVSSSRGGTPVPSNVGAIAPLQNALRLSRRIPDFTVKMFRTTCNSDGNIVIEKEQTILIAEIKPAIKDSENLSEIRRHLSMFWLLPLFGKLDA</sequence>
</entry>
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    <protein>
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        <lineage>
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        </lineage>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
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                <person name="Ferreira P."/>
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                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
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                <person name="Hesse C."/>
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                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
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                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH40231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="63" mass="6769" checksum="80E098360D5B190F" modified="2018-01-31" version="1">MPNHPAIECDTPRVRTDPGRPLPPSRATRLTNATRHTPRGPPDQGATSPSKISCLHRIPAPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JED9</accession>
    <name>A0A2H3JED9_WOLCO</name>
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        <recommendedName>
            <fullName evidence="7">TAFII55 protein conserved region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WOLCODRAFT_66898</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF7 family.</text>
    </comment>
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        <property type="protein sequence ID" value="PCH38173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JED9"/>
    <dbReference type="STRING" id="742152.A0A2H3JED9"/>
    <dbReference type="OMA" id="KWEKMQN"/>
    <dbReference type="OrthoDB" id="153872at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08047">
        <property type="entry name" value="TAF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037817">
        <property type="entry name" value="TAF7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006751">
        <property type="entry name" value="TAFII55_prot_cons_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12228:SF0">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN ASSOCIATED FACTOR 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12228">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID 55 KD SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04658">
        <property type="entry name" value="TAFII55_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01370">
        <property type="entry name" value="TAFII55_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
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        <location>
            <begin position="56"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
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            <end position="324"/>
        </location>
    </feature>
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        <location>
            <begin position="369"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="254"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="369"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="387"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PCH38173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="418" mass="47609" checksum="C6C37A1D44FC1862" modified="2018-01-31" version="1">MDYSETRTTRSAANRNKPQPKLKLKLSEKAAAQAPGMSFLGPYDRELDSDDEDLVFEEQFVLRMPPGEDCEKLRKMVAAREVNNDVWFKFKDSRRAVFHIGNNTYSSKLVDLPCIIESQKTLDNKQMFKVADICQMLVVGQPIDNEDALTSQRKFDVDEFIWHHGITPPLHHVRKRRFRKRVNRRTIETVEQEVERLLEEDALASEVKYAVLENVNPDLSDSEFMEKDEHLDPNTPGFLGSDAGDTPTPGPDMGEGDEEGEGHEDDDEGDIDEDLAAELDLALGDEEAEGDDEDEDEDEDDEDEESEEEDDDEDDETVQARKLLNEEIRDLEAAVAKKQHEIASSANPLIRRRFEDALRKLQSDLDMKLAQRDEMKEKQRMKKEGIIPEDEMEGGNEAEGGDDQDESLFGDEPGMDVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JEL7</accession>
    <name>A0A2H3JEL7_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_162452</name>
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    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH40680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JEL7"/>
    <dbReference type="OrthoDB" id="2340858at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH40680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="412" mass="46303" checksum="7CAF06C41C95933E" modified="2018-01-31" version="1">MNSRDLQAWEGAEKPSESDLADFSQLFGTSARRVFFQAAKLKDYADEFHLKISRLNRENFSELLDRAVSAEIDGAIIHDIFVATPSPGNRKKFDLQISTAYLSYMEFLYQGCRRSPLIRLLAKFPNGGERPMTAMKTSAGVRENTHWHSNGLSSPLRYLRLGCPGHMVAIVNDQVDLPVEEFDRLDRYYFSQGDRQTLRSGFYISRAEFQPTFDAFVYDEGPRRATIFKATVSDRHDISTAGLDWLYTCCVKSINLVVAVPPLSGDFVENFQVANSHRDKLGNVYHLELQDLKEVAGSTGREEARSGQSRGPNGQRTDPSDQDTELEHVTSTEMVFTATAARSRKHERLAAAIDNGEVDNPEARLSRQYGALPSSQKPPLKHKRGLTGSTGEAIDESTRPSLRWKKSRRQGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JFK2</accession>
    <name>A0A2H3JFK2_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_145495</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
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            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467832">
        <property type="protein sequence ID" value="PCH34777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JFK2"/>
    <dbReference type="STRING" id="742152.A0A2H3JFK2"/>
    <dbReference type="OMA" id="KHIAITH"/>
    <dbReference type="OrthoDB" id="6910977at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="268"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH34777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="298" mass="32810" checksum="4A11014E5E2406DF" modified="2018-01-31" version="1">MPYHNGINPALDASDFLISSMDSPNTELPMSSAQAGTCSPILVFWPDLISGFKSVDSVTTTPFTYDDSALKDDHLIPHLPSIASATHSQPPDFEPPTAGWRSELSIQQLAGGDFTTQEWKTETGISAAMWNETNVAHSHPLQFAPNPELMTLESASWDHDGGESIQHKRECSATTDSIPSWSRNCGRGESIVKLVQCLWNGCRHHLQLPKASEIKDHLRSHHSISLSASSSTRITCQWDHNGYMCGRKMYHRSLVKHIAITHLKADGGTCPACGEKFGRRDSLKRHTIAQHPFKSCGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JFU1</accession>
    <name>A0A2H3JFU1_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_33044</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467936">
        <property type="protein sequence ID" value="PCH37619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JFU1"/>
    <dbReference type="OrthoDB" id="3209382at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH37619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="209" mass="23865" checksum="06F765754F040E8A" modified="2018-01-31" version="1" fragment="single">LSAILPIPIYLQRLNDTTAIRLRTLPTQSQPLQRLNQPQKQPYPLSKCTIQKHMPYTTPLLYLNSLLPKHTDHTYPFEQTPWHPMTKWGSRLQWDLLGTNASKDTKKAHLTHIRSIIDLSTTSSSTICVYTDGSTRPLLPHRFFSGASYLITHLETNIHQRLYGLGRTVTTYDAETFALSAASHYLTHILTNHPDTTTIHYFTDNTTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JFY3</accession>
    <name>A0A2H3JFY3_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UPF0183-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_89018</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PHAF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH41096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JFY3"/>
    <dbReference type="OMA" id="YRKNDQK"/>
    <dbReference type="OrthoDB" id="411211at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005373">
        <property type="entry name" value="PHAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039156">
        <property type="entry name" value="PHAF1/BROMI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13465:SF2">
        <property type="entry name" value="PHAGOSOME ASSEMBLY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13465">
        <property type="entry name" value="UPF0183 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03676">
        <property type="entry name" value="PHAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH41096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="379" mass="42717" checksum="409CB7A421039F7E" modified="2018-01-31" version="1">MVSTLETDIRPGLGLGKFELGSSLWSVIELLRGMQHVFPMVDVKFDPDTPTTPVILHIRPHLDLLFSGHHQRLHTICLRRLRDLNPPVTLKYKDTTLSSSEEVLRRVGVSRTFGPTYPGDDLQYPGVSFSFEEDGRNDGLKSPTLHTEDRMQEVKRVIVTQKNAPGEVRDALGEVTECSAMDGEIKRAVVKVHDGVTLDFFPSNTNSVRVRIGISTAQDLICDLGQPLRIHYKEDDRMTIHSRNAFADIQGDTDYFYNYLQHGIDFLMSGTTHVVKKIILHSNVPGTPLFQRYKRCPWEIEGKPEDNEDESPSRVRFYDRADVIGHFLSPGESPPSMLLDRTDEEDGLTLPSSKTRLLGFDGVILEATESEQVVAVMLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JG04</accession>
    <name>A0A2H3JG04_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_28690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467887">
        <property type="protein sequence ID" value="PCH36628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JG04"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH36628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="52" mass="5970" checksum="D9B4DB3B65EF7882" modified="2018-01-31" version="1">MNYGHWISRSNSLWKKYITCRPPIKAEPVADYDVGWSNPETSSTKNATAKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JGC0</accession>
    <name>A0A2H3JGC0_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_151258</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH41216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JGC0"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH41216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="123" mass="13842" checksum="C84A3E5FE4B4C635" modified="2018-01-31" version="1">MRQHTNQRPRYAATPPSDNPRRTMGITSMQCSRFLLPCPIGSKPTGMPLPVLCILIGGQRRQEPTRQRRHIRQRPDATYNRVHSRLRIRTRARAVVGARAISLPAPSMHGRAHLGVPRDGPTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JGG5</accession>
    <name>A0A2H3JGG5_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF202 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WOLCODRAFT_71438</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH40991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JGG5"/>
    <dbReference type="STRING" id="742152.A0A2H3JGG5"/>
    <dbReference type="OMA" id="MAIMIYA"/>
    <dbReference type="OrthoDB" id="2243669at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033254">
        <property type="term" value="C:vacuolar transporter chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051572">
        <property type="entry name" value="VTC_Complex_Subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140:SF1">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE COMPLEX SUBUNIT 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="DUF202" evidence="6">
        <location>
            <begin position="24"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PCH40991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="127" mass="13949" checksum="613622822C71CA34" modified="2018-01-31" version="1">MSTQPLLQRTAAKRIALPVRVEPKVSFANERTFLSWLHFTVVLGGLAVGLLNFGDQVGKISAAMFSVVAMAVMVYALYTYHWRAASIRKGGRGPYDDRIGPTVLCVALLVAIVVNFILRFSQPDLNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JH79</accession>
    <name>A0A2H3JH79_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA(adenine(34)) deaminase</fullName>
            <ecNumber evidence="3">3.5.4.33</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WOLCODRAFT_119196</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>adenosine(34) in tRNA + H2O + H(+) = inosine(34) in tRNA + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:43168"/>
            <dbReference type="Rhea" id="RHEA-COMP:10373"/>
            <dbReference type="Rhea" id="RHEA-COMP:10374"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:82852"/>
            <dbReference type="EC" id="3.5.4.33"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidine and deoxycytidylate deaminase family. ADAT2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.33" evidence="3"/>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH41550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JH79"/>
    <dbReference type="STRING" id="742152.A0A2H3JH79"/>
    <dbReference type="OMA" id="PCQMCAG"/>
    <dbReference type="OrthoDB" id="1701769at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052718">
        <property type="term" value="C:tRNA-specific adenosine-34 deaminase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052717">
        <property type="term" value="F:tRNA-specific adenosine-34 deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002100">
        <property type="term" value="P:tRNA wobble adenosine to inosine editing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01285">
        <property type="entry name" value="nucleoside_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000039">
        <property type="entry name" value="tRNA-specific adenosine deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079">
        <property type="entry name" value="CYTOSINE DEAMINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079:SF149">
        <property type="entry name" value="TRNA-SPECIFIC ADENOSINE DEAMINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="9">
        <location>
            <begin position="16"/>
            <end position="132"/>
        </location>
    </feature>
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    </evidence>
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                <person name="Barry K."/>
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                <person name="Hori C."/>
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                <person name="Kallen N."/>
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                <person name="Ling A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="194"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH41700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="259" mass="29598" checksum="BAE781EA18BBCDA7" modified="2018-01-31" version="1" fragment="single">RKEKVPPPPEFSGAEGKVQAKEWIEKLGLYFSKVKPADDEERITTALYRLSGEAYRFMGPLLEKAGNGEPLGTWADFKKQILNQYAKKTDKEIAEKEIKAFYGSNGKKKVETNFFTYCSKFRTLGRLSEIDGTTLLREFKEVLPEKVRDHVAILTRVTPAAIPADWDKYVDLCLELYKIAYPDKLDGSIFKEEKKEKKEEKKEQPKETAPKKAYSKGKGKATTTSAEKKPAENTEQVCSYCKQKGHFFKSCTKLKKDKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JHR1</accession>
    <name>A0A2H3JHR1_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_85527</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467987">
        <property type="protein sequence ID" value="PCH39373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JHR1"/>
    <dbReference type="OMA" id="TWRISEP"/>
    <dbReference type="OrthoDB" id="2758165at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="576"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="723"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="741"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="761"/>
            <end position="771"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH39373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="944" mass="105884" checksum="7A45FB2671072795" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JHZ4</accession>
    <name>A0A2H3JHZ4_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WOLCODRAFT_101218</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH41802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JHZ4"/>
    <dbReference type="STRING" id="742152.A0A2H3JHZ4"/>
    <dbReference type="OMA" id="ATSKLCM"/>
    <dbReference type="OrthoDB" id="202470at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43103:SF5">
        <property type="entry name" value="4-EPIMERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G00360)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43103">
        <property type="entry name" value="NUCLEOSIDE-DIPHOSPHATE-SUGAR EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="4">
        <location>
            <begin position="29"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PCH41802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="310" mass="34584" checksum="A129FAA61806AE97" modified="2018-01-31" version="1">MSRPLSFTATRALGVQADEFETRAPKPRVVVTGGSGKLGRHTVVELVEHGWEVINFDIQRPPADAPKDAIFMHTDLESMGEVMENLVDVDTKYKGIDAIVHLAALPAPGMMASSRQFQLNAIATYNILEASRKLGIKNLVLASSETLLGLPLNPWLPDYIPMDENSPRRPESAYSLSKLVGEVMSEEYARWDPTTKIVSLRFSNVQSPEDYAAFETWQHDPLIRKWNLFGYIDARDGGQAIRKSLEYKATGHHQFLIANNNTTMRAPNAELVAACFPGIPYTPTKGRNDTLLSIEKAKRVLGFAPKYDWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JI09</accession>
    <name>A0A2H3JI09_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">WOLCODRAFT_68937</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">MD-104</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH41812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JI09"/>
    <dbReference type="STRING" id="742152.A0A2H3JI09"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="452"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
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        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PCH41812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="527" mass="58961" checksum="CF389F8EE2DF268F" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-09-13" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JIH9</accession>
    <name>A0A2H3JIH9_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_141364</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468042">
        <property type="protein sequence ID" value="PCH39683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JIH9"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH39683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="421" mass="47036" checksum="14343D0B9EA35266" modified="2018-01-31" version="1">MKFSCDTAASHAPIELWELILDFLWDEPAALVACTTVCTDWHPRSKLLLKNLDSSNAHELSNPEDVRRLAKLLHAMPFKRQTSRRVRITGNPAASGSLAHIAAFAASLVEKFPSVYSLEIHNGSWRPGSIQLTSALLHLSAFRIVMLDLDGITLPSITVFGRLIASLSRLKGLRLGNLYFSDGRLPVPLYRRWKTLPKLTAIHVECASVAVLDALAATHLTENCNLLYLRDLTIPHFQPLEHGVRSSNLKSMLWNSKDSLKHLYIETCPQVEIDMTQEPTLSDDVDLSCSTALKDLRLTIGFHSSTVSSRHTEWVLHLMSNMSGPSSLERIVLRLRRLSGKFSIANIREIIRGYAQLDRVLCAPRLPLFRSLQFKIDLHPDGMKSAEGIWHEAAPRYFSSLVASSKLSVQWVLSGLGKVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JIK7</accession>
    <name>A0A2H3JIK7_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WOLCODRAFT_43290</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468124">
        <property type="protein sequence ID" value="PCH42030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JIK7"/>
    <dbReference type="STRING" id="742152.A0A2H3JIK7"/>
    <dbReference type="OMA" id="WINHLEF"/>
    <dbReference type="OrthoDB" id="538223at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF637">
        <property type="entry name" value="WD REPEAT DOMAIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="8"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="50"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="146"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="188"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="230"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="272"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="316"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PCH42030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="417" mass="45006" checksum="771E89B7F3C30290" modified="2018-01-31" version="1" fragment="single">WDACLRVIGDHTHWVRSVTFSPNGRWIASASHDNTVRMFDAVSGTTLNTMRGHTSWVVSVAASPDSQFAASGSYNGEVGIWSTASGALTKVLRPPEDAIHIKEVVCVAYSPDGRTVVTGSRLEIKRVIMLHIWDPDTGACLQSTIVGGDPTYVRSVVYSPDGARIVTASRDGLLRTWDSQTLVCKATYNGHTNQVQSVVFFPDGAKLVSGSWDKMIRIWDATSAKCTQMLEGHANKVMSVAISSKGDLIASGSEDYTIRLWDAQSGEALATIEGHTKEIWSVGFSPEGNHLASGSQDKTVRVWDLQAIPKQSSLQLMGHVTSVFCMSFSHNGAQLATGDGKGNIIIWCSNNQGANKGSSDTCSVVRTVAFSPDGMMLAASGHTTIGIWSVASHVLTQEIQLTLKDYGWINHLEFSLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JIU4</accession>
    <name>A0A2H3JIU4_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6593 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_137583</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH41781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JIU4"/>
    <dbReference type="STRING" id="742152.A0A2H3JIU4"/>
    <dbReference type="OMA" id="IMRHIAA"/>
    <dbReference type="OrthoDB" id="2910790at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046528">
        <property type="entry name" value="DUF6593"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20236">
        <property type="entry name" value="DUF6593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6593" evidence="1">
        <location>
            <begin position="47"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH41781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="190" mass="21633" checksum="FBB6BF59C9D147AB" modified="2018-01-31" version="1">MINRSLPYFLEDRTGQFTGSSFDDIYDRLFLRVAHPTEGPGADTTLMLYNVGRRSSSQRDYRPLKRDPSVVLEFAPGGALGRISFVGSSIAMPMGQYLKKTSMFGSSLSRKFRASDGQEYRWTYRSVQDQEWSCFDSRNFLVAHYNLRPPEKPVFSTSGNILTIYEAYVHLSIEILASLTIMRHIAAHNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JJ45</accession>
    <name>A0A2H3JJ45_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_166607</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467865">
        <property type="protein sequence ID" value="PCH36007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JJ45"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH36007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="122" mass="13392" checksum="E7888A9819BFDE35" modified="2018-01-31" version="1">MMADPDDYTDVRMLSGVRVHETPGFRLYRPFPLAVPNAISRFEDYLPYAAAAAVSGPHRCYDFLLRRMLHDVADSVCIKTSPIGAPNKLIVRAVRTFTVPAAIYAGSCSSCPNALIPAYSQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JK65</accession>
    <name>A0A2H3JK65_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Mitochondrial Rho GTPase</fullName>
            <ecNumber evidence="15">3.6.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">WOLCODRAFT_116954</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 15">Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 15">Mitochondrion outer membrane</location>
            <topology evidence="2 15">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the mitochondrial Rho GTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="15"/>
    <dbReference type="EMBL" id="KB468053">
        <property type="protein sequence ID" value="PCH40253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JK65"/>
    <dbReference type="STRING" id="742152.A0A2H3JK65"/>
    <dbReference type="OMA" id="HETTWGI"/>
    <dbReference type="OrthoDB" id="10020961at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01893">
        <property type="entry name" value="Miro1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01892">
        <property type="entry name" value="Miro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000011">
        <property type="entry name" value="Mitochondrial Rho GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000553">
        <property type="entry name" value="Mitochondrial Rho GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001330">
        <property type="entry name" value="Mitochondrial Rho GTPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013566">
        <property type="entry name" value="EF_hand_assoc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013567">
        <property type="entry name" value="EF_hand_assoc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021181">
        <property type="entry name" value="Miro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052266">
        <property type="entry name" value="Miro-EF-hand_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020860">
        <property type="entry name" value="MIRO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46819">
        <property type="entry name" value="EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46819:SF1">
        <property type="entry name" value="EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08355">
        <property type="entry name" value="EF_assoc_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08356">
        <property type="entry name" value="EF_assoc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037488">
        <property type="entry name" value="Mt_Rho_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
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            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
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                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
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                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PCH42045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="227" mass="25838" checksum="27EADFCC2EF24E33" modified="2018-01-31" version="1">MEPTSEATLRRNGASEHDDEHRNSLLRRSWHAMSDILSPFSPSALASLPKRTLRRRPRYTRNDNVPETSRDEDGQMPTVRDYHAINSVPPQVRVPKKIATPIKVEGKVWFANERTWIAYLNTSVLVGTLALALFNASKDQIARNIAYSYAAISVGILVYGYAVYQRRISLIRKRDPGPFDQIVGPVLISACLFFAVLVNFILRVRELQRKSVPIPGLTYLSSYYYKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JKZ1</accession>
    <name>A0A2H3JKZ1_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">beta-glucosidase</fullName>
            <ecNumber evidence="4">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WOLCODRAFT_25587</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="4"/>
    <dbReference type="EMBL" id="KB468135">
        <property type="protein sequence ID" value="PCH42860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JKZ1"/>
    <dbReference type="STRING" id="742152.A0A2H3JKZ1"/>
    <dbReference type="OMA" id="ESTHYTI"/>
    <dbReference type="OrthoDB" id="416222at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000002">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1700:FF:000003">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF2">
        <property type="entry name" value="BETA-GLUCOSIDASE F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013756374" description="beta-glucosidase" evidence="11">
        <location>
            <begin position="21"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type III-like" evidence="12">
        <location>
            <begin position="898"/>
            <end position="967"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PCH42860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="978" mass="103726" checksum="95D5AF9322288067" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JL14</accession>
    <name>A0A2H3JL14_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_144253</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468135">
        <property type="protein sequence ID" value="PCH42880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JL14"/>
    <dbReference type="STRING" id="742152.A0A2H3JL14"/>
    <dbReference type="OMA" id="VENIYFR"/>
    <dbReference type="OrthoDB" id="2803047at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="1">
        <location>
            <begin position="48"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH42880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="540" mass="61002" checksum="8FCF9CA50EA73BE0" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JLK2</accession>
    <name>A0A2H3JLK2_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_25718</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468135">
        <property type="protein sequence ID" value="PCH43086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JLK2"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH43086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="270" mass="28575" checksum="45E0F5B8CE8C9CA3" modified="2018-01-31" version="1">MSIDLDGEESMQLSLLMASTGTLATGANLLQVDGLPITSALASPMLSPFETDDSMSPLVISTPLLLDALPDESMNIEGTMFSPAMVSAEPAPPALLFMPTPQPLAGSLSSLILPSALSVVDDFDLAASAFTSDHVLVAPVLALIPLPDTLEGVYLEEQLPAYSEMAEMAAIVDFSKPPTYSEAINVLEIVAIADVPSAPVLSMADLPVAGTFENMPMPPASPVWTSYFTIQETYDMRLPLQLPQPTPRGSWTRGNDIILASFGHLPTSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JM38</accession>
    <name>A0A2H3JM38_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">WOLCODRAFT_25827</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">MD-104</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468135">
        <property type="protein sequence ID" value="PCH43276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JM38"/>
    <dbReference type="STRING" id="742152.A0A2H3JM38"/>
    <dbReference type="OMA" id="ATIWGRM"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="437"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="432"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PCH43276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="506" mass="56626" checksum="881DCE8B3C5F8AD9" modified="2018-01-31" version="1">MAIVLLVNVIFKKEKARLPLPPGPKGLPIVGNIRDVPKSHEWLAYERWGRVFDSDIIHLNLCGTPVVVVNSTSAAYELFERKSSLYSDRPRMTMLNDLVGCDWHFVFMGYGDRWRERRRIFHQHFHPSAALQHRPKALKGARVLLYRLLETPDDFMTHLRHMAGALIIGVAYGLEVQPKDDPYVATAERALHAMAMAGNAGSFLVDYIPILKYVPTWLPGAGFKRKAMEWRKSTTAMVEVPYKAVKKAISDGIAAPSMILSLLSNIDIEEDENAPRLEKLYSGVAAAAYTGGSDTTVSALGSFFLAMLLYPEAQAKAHEELDRMLGNHRLPDFSDAPSLPYTTAIVQEVLRWRPVTPLAVPHRLTQEDEYEGYRLPAGSIVVGNSWAMLHDEKQFPNPSAFIPERFMTADGELNPTMKDAELPAFGFGRRICPGRNLAYASLWISIASVLAVFTIVKKVNEKGEVIEPRDEYTSGLVTYPLPFDCIFKPRSETAEALIRTALDDVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JM41</accession>
    <name>A0A2H3JM41_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_17825</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468124">
        <property type="protein sequence ID" value="PCH42575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JM41"/>
    <dbReference type="STRING" id="742152.A0A2H3JM41"/>
    <dbReference type="OrthoDB" id="2795723at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21037">
        <property type="entry name" value="MLKL_NTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.20">
        <property type="entry name" value="Adaptor protein Cbl, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036537">
        <property type="entry name" value="Adaptor_Cbl_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059179">
        <property type="entry name" value="MLKL-like_MCAfunc"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH42575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="160" mass="17935" checksum="F7A469AFAC1B94E5" modified="2018-01-31" version="1">MPFWTSKHTDSTLSAISLALRGIKAASSLINGVPGLELAVGSALSLVTTIQVRGNKERAHRLAELVMNSIEHLYKSVASRLDAIDERLERDITTLRRKLLGTQQKIEKQLRKRMHKRILNHHAMSRILDECATDIDDARQVFLVHKTGICFLLLLTLACS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JMW5</accession>
    <name>A0A2H3JMW5_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_137266</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the complex I NDUFA12 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH41243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JMW5"/>
    <dbReference type="STRING" id="742152.A0A2H3JMW5"/>
    <dbReference type="OMA" id="WHGWIHH"/>
    <dbReference type="OrthoDB" id="274641at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007763">
        <property type="entry name" value="NDUFA12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12910:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12910">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE SUBUNIT B17.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05071">
        <property type="entry name" value="NDUFA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0249">Electron transport</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH41243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="139" mass="16480" checksum="059EB985A28984A9" modified="2018-01-31" version="1">MPSLARYIRSVRRIGIKEWWHQMQYIGDAKSGKFVGKDQFGNRYFENLNPEEEVPGRHRWVDYAQHDFNATQVPAEWHAWLQHIRKEPPPEDRVMQNLSPPWKAPWVENLTGTRGVYRAYNTTKPKIEAWEPKVAPRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JMZ5</accession>
    <name>A0A2H3JMZ5_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GST N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_150218</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468053">
        <property type="protein sequence ID" value="PCH40179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JMZ5"/>
    <dbReference type="STRING" id="742152.A0A2H3JMZ5"/>
    <dbReference type="OMA" id="PWRFTEK"/>
    <dbReference type="OrthoDB" id="4951845at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050983">
        <property type="entry name" value="GST_Omega/HSP26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054416">
        <property type="entry name" value="GST_UstS-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968:SF6">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE OMEGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22041">
        <property type="entry name" value="GST_C_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="7"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH40179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="249" mass="28310" checksum="3C7E2769CA4F2938" modified="2018-01-31" version="1">MITLYDIPSDIKVIAWSPNTWKTRFALQLKGLEFETVWIEYPDIADLCKKIGAAPSGTKDDGSPDYTLPVIHDSSTNTVVSESGLIARYLDKAYPNTPALIPQETDALHGAFQEAFLLTIEQRILPLMLPPTNAYLHPPSEAYFRRTREAKFGKKMEEISPGGPVREAQWEKLRGGLTKLAEWLELDGKEKLFFTGDRVSHADLSIAGWLIWIKLILGVDSAEWLAVKTWDGGRWGRFMEHFEQYEKVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JN99</accession>
    <name>A0A2H3JN99_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WOLCODRAFT_25869</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468146">
        <property type="protein sequence ID" value="PCH43371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JN99"/>
    <dbReference type="STRING" id="742152.A0A2H3JN99"/>
    <dbReference type="OMA" id="EPHEDIG"/>
    <dbReference type="OrthoDB" id="2797003at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="3">
        <location>
            <begin position="24"/>
            <end position="63"/>
        </location>
    </feature>
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        <location>
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            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PCH43371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="367" mass="40473" checksum="596C7FA464B9B2CE" modified="2018-01-31" version="1">MSSPTTFPAAEEIEYLTRIYTTNYCLAAVAALVVYEHIITFDREVFAIWRYRMTGATALLLFNGSVLLLTAVSNVLETFIWNSDQICKVQLVPTAVKYVLSVVIAAGFSALRVYAIAGRNWYWTLLALLTGLVPAATNIYQYISDSHPHVEYFFGIPQCMQTISLSDSVFDGLLITTRTCAIVSDLVVIAATWMYARPWGRYASNTQIKTPLMAVIVRDGETVEVLLILNITQMAIQGVSYFTSGAIYWDYITTFIPVISSILTSRFIFNLRQHTDEGNSTGSNAPSFVAGSMGSRGSIEYGNRLVGNMGAPLDHSIPDSLLFDDGDEPHEDIGCNEKLPVEQAHNVERRGEGRSDAENEVGTVTTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JNN7</accession>
    <name>A0A2H3JNN7_WOLCO</name>
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        </submittedName>
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    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
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            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468146">
        <property type="protein sequence ID" value="PCH43511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JNN7"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH43511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="218" mass="24149" checksum="EBA080883DC9DCB3" modified="2018-01-31" version="1">MPRNKRPATKGSRIVFYQLYTKGGRRMGARNNVRAELEDGYPPGYKPDERDLYLGTLESAELASTDANVPHTCTAGAFKQLICAKERLDPKFVHVYVRFLVGAPLGDAEPIDLGLNGAGLTADVPLALMMRSHHRARRPGRMDDMVCALPPISADFRKRLRTKYTHNAQFAGFLSYTAGEVLVTDGTLGWDGAPTCYMARNKEGEEGYISFYSAELLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JP98</accession>
    <name>A0A2H3JP98_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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        <name evidence="2" type="ORF">WOLCODRAFT_164877</name>
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    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468157">
        <property type="protein sequence ID" value="PCH44020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JP98"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="193"/>
        </location>
    </feature>
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        <location>
            <begin position="292"/>
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        </location>
    </feature>
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        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="307"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH44020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="486" mass="51045" checksum="6CCECACAE203F42E" modified="2018-01-31" version="1">MGHSLPMRHSRHLTNPPSFYTAPVHSAVASASAQFAPRTIAITIYPVQPGEARGTAAPVRAPALLGAPWRCGEDACACLPVHWLAPSCAIGLAYAWRGEAGRREAIRGTAGCCARGCVSARFAKGRTVGAPKPKPLGQLSPSPPRTTARAPSSFSLTTPGPRAWTSSPRTRRRAVRAWTRQRTLSPKSATDGRGLLRAHITAPPTVPGSPPRCVDVWMTSAADCDPAGRPPAMHAGVRVGDPGERQQCVQAEGACVRWSPSVRMTHSVSGTENWPACAAPPGRRFAPPCPPEKLRTGHPRLRRTQSAARTGRPGPRRTLGFGAASTPVGFADHAGLRTRGGSELDPGPHAAAAAARHSTQRIGPHIQSIPPRLLRPSRYPISADAVQSWITRTVSVSATISGAWRSNSTSSAAGSLEACGIAYRAGRARRLLPQEALLLCGRRFEGACSAETASALAAELRGSASPASCQATGLLRVVRGRLLLAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JPD8</accession>
    <name>A0A2H3JPD8_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_144801</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Agaricomycotina</taxon>
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            <taxon>Phaeolaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468157">
        <property type="protein sequence ID" value="PCH44060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JPD8"/>
    <dbReference type="OrthoDB" id="2801815at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="2">
        <location>
            <begin position="58"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH44060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="186" mass="20916" checksum="BFEDED6111ED0995" modified="2018-01-31" version="1">MRLIAMDYLLTVVVIGMVQSFYLQNIIDRNWWHSSNMMTFLSTTSTLYTMSIQLTGLVITDVFIMTTLCCTFNGFKTGFRSTNSMLSKLMSLTLQRGILMCAAEIGILAATYSLNYSICFHEEFVRDHLYGSHSFCLLYFPLGTELAIVTRDDLAVYANTLLASLNARNYLRNAGNTTSRGSAIIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JPR4</accession>
    <name>A0A2H3JPR4_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_153941</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468146">
        <property type="protein sequence ID" value="PCH43891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JPR4"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH43891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="177" mass="19997" checksum="089A5448651174A8" modified="2018-01-31" version="1">MACSQLVQKERLCLYDLWHNVNAELQSLRDPSSRIDTAPRTHPHPGYVRTRLFIFRRPRRMMQPIKNMSDCSRLWPVLAPQVIPCMSAVRKSTLLTTIMMNPSSRAKRREKQHMTTPRGGTAGGRGPILSDAAKQPRGRAGLRAFPEHSGGVREASRPHCYRSGTRRTHTQIPGVHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JPZ1</accession>
    <name>A0A2H3JPZ1_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="7">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WOLCODRAFT_71175</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="7"/>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH40869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JPZ1"/>
    <dbReference type="STRING" id="742152.A0A2H3JPZ1"/>
    <dbReference type="OMA" id="QQANKAW"/>
    <dbReference type="OrthoDB" id="420187at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02661">
        <property type="entry name" value="Peptidase_C19E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000119">
        <property type="entry name" value="Ubiquitin specific peptidase 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF758">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="9">
        <location>
            <begin position="127"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="77"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PCH40869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="425" mass="47271" checksum="34C6E0840AC401B0" modified="2018-01-31" version="1" fragment="single">MPAGFSEDATQYRPVENIDAFKNLFPPPIEFVEGSSSGSFVLDEGKYQPINSVSTAPRTEVRTEQPPEVLPSVEAIAEPQPQEAKPTTQPAPSTAKAPKLSHSTVAGKDLYSGNLNTTWPSRASIGAGLQNTGNTCFLNSALQCLLHTPPLLHILQSHSQTDPFAKNAFCMTCGLRQVMLETHERRRSYAPYPIVTKLQVIAKSMRRGRQEDAHEFLRYAIDALQKSCLAGHPAKIDPKLAETTWVHKIFGGRLRSRVTCLDCGYNSDTFDRILDLSIDIYGVNTLKEALRKFVAVDHLKGADKYKCEKCKKPVTADKQFTLHEAPLVLTIHLKRFSPMGRKIGHPVKYDERLSLQPIMSDGQYGPTYSLYGIISHAGGGPNSGHYYAHVKSADGHWYEMNDESVSRQFGSPTTMKNAYILFYIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JQM8</accession>
    <name>A0A2H3JQM8_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Argininosuccinate synthase</fullName>
            <ecNumber evidence="3">6.3.4.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Citrulline--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">WOLCODRAFT_90852</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MD-104</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the argininosuccinate synthase family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.5" evidence="3"/>
    <dbReference type="EMBL" id="KB468157">
        <property type="protein sequence ID" value="PCH44452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JQM8"/>
    <dbReference type="STRING" id="742152.A0A2H3JQM8"/>
    <dbReference type="OMA" id="WRWTVSP"/>
    <dbReference type="OrthoDB" id="1688907at2759"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00113"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004055">
        <property type="term" value="F:argininosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000053">
        <property type="term" value="P:argininosuccinate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000050">
        <property type="term" value="P:urea cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01999">
        <property type="entry name" value="ASS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000019">
        <property type="entry name" value="Argininosuccinate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1260.10:FF:000003">
        <property type="entry name" value="Argininosuccinate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1260.10">
        <property type="entry name" value="Argininosuccinate synthetase, chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00005">
        <property type="entry name" value="Arg_succ_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048268">
        <property type="entry name" value="Arginosuc_syn_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048267">
        <property type="entry name" value="Arginosuc_syn_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001518">
        <property type="entry name" value="Arginosuc_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018223">
        <property type="entry name" value="Arginosuc_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023434">
        <property type="entry name" value="Arginosuc_synth_type_1_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024074">
        <property type="entry name" value="AS_cat/multimer_dom_body"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00032">
        <property type="entry name" value="argG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001770">
        <property type="entry name" value="PRK00509.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11587">
        <property type="entry name" value="ARGININOSUCCINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11587:SF2">
        <property type="entry name" value="ARGININOSUCCINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20979">
        <property type="entry name" value="Arginosuc_syn_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00764">
        <property type="entry name" value="Arginosuc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69864">
        <property type="entry name" value="Argininosuccinate synthetase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00564">
        <property type="entry name" value="ARGININOSUCCIN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00565">
        <property type="entry name" value="ARGININOSUCCIN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arginosuccinate synthase-like N-terminal" evidence="12">
        <location>
            <begin position="9"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Arginosuccinate synthase C-terminal" evidence="13">
        <location>
            <begin position="182"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00060987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF20979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PCH44452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="428" mass="47623" checksum="6EA45671BADF003A" modified="2018-01-31" version="1">MSASKSKGRVLLAYSGGLDTSCILAWLIEQGYEVYAFMADVGQEEDFEAARKKALAVGAKKFFLEDLKREFVTELIYPAVQANCIYENVYLLGTSLARPVIARGMMAVADKEGCDFVSHGCTGKGNDQVRFELAFYGLKPDIKVIAPWRIPEFYSRFAGRQALLAYAAEKNIPVQQTAAKPWSTDENLFHISYEAGILEDPNTTPPADMWKLTTAPEDAPTTPERISIEFARGIPVKVTVPAENKTYTDAVDVFLALNALARKHGIGRIDIVENRFIGVKSRGCYESPAATILRVAHMDLEGLTLDRNVRALRDQFVTVELSRMLYNGHWFTPEREFIVSAIPASQRTVNGVVRLKLYKGNVVVEGRLSDEGLYDEKQSSMDELGGFEPTDTTGFIQIESIRIKKWAQANIRKGQAGIEPKDVYGTRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JQP3</accession>
    <name>A0A2H3JQP3_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_128896</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467943">
        <property type="protein sequence ID" value="PCH38984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JQP3"/>
    <dbReference type="STRING" id="742152.A0A2H3JQP3"/>
    <dbReference type="OMA" id="CRENFIA"/>
    <dbReference type="OrthoDB" id="2752444at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH38984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="226" mass="25887" checksum="132C915FF3BDEF66" modified="2018-01-31" version="1" fragment="single">MSPADTYDYQLNPSESMTSRIPKLREDGTNWILYKEQFRAAVLAKELVRFLEGRDREPRAPEIPGEDSEADEEYESAHDIWIAKHQSIRTLLFQTLPESLKLRIAPLEKASEAWRAVVEEYDDQGEFVQVEILRQMHALRCEENSDPRPTLNQLERLKSEHATAGGQLSDNEYKAIVLSCLPLSYRAVTTTKLTLTEFHRRMGHAYAPALRKMVEKGVVTGVTLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JQV0</accession>
    <name>A0A2H3JQV0_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Integrin alpha N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WOLCODRAFT_15831</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TIP family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH38397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JQV0"/>
    <dbReference type="OMA" id="PGDWIPW"/>
    <dbReference type="OrthoDB" id="10022113at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="entry name" value="Integrin alpha, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057089">
        <property type="entry name" value="C2_TIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024881">
        <property type="entry name" value="Tip"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13412:SF0">
        <property type="entry name" value="T-CELL IMMUNOMODULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13412">
        <property type="entry name" value="T-CELL IMMUNOMODULATORY PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23122">
        <property type="entry name" value="C2_ITFG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13517">
        <property type="entry name" value="FG-GAP_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0401">Integrin</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013796563" evidence="9">
        <location>
            <begin position="21"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="632"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="domain" description="T-cell immunomodulatory protein TIP C2" evidence="10">
        <location>
            <begin position="529"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PCH38397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="678" mass="73518" checksum="07CFC02859996AB4" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JQV8</accession>
    <name>A0A2H3JQV8_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GroES-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WOLCODRAFT_29355</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD-104</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
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        <property type="protein sequence ID" value="PCH39054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="742152.A0A2H3JQV8"/>
    <dbReference type="OMA" id="GGHDRTC"/>
    <dbReference type="OrthoDB" id="1560166at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF7">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE-LIKE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="6">
        <location>
            <begin position="19"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PCH39054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="339" mass="36260" checksum="365073AAEE854D73" modified="2018-01-31" version="1">MAADHPSTYKAYAFLERGGPLKQIQVEWKDPQPGHIVIKVLACGVCASDEVAKYQMWPTVAYPRIPGHEIIGDVVAVPSTEKLWKVGQRVGSGWHGGHCHACERCRTGDFTMCASQDINGIGRDGGYAEYVTVRTEAVASIPNDIDPAEAAPLLCAGLTVFNALRHMNAVPPNLVAVQGIGGLGHLAIQIAKAMGFRTVALSSSSSKKELALKLGAEEYFDGSQVNQAQELLKLGGAQLIACTAPNPEVIQTLVEGLAVDGELCILALTGAATIPLLPFVGKRLSIRAWNTGTPRESEECVEFVKASGVKTYVQSFPLDKAQEAYDHRSSARFRAVLVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JRP8</accession>
    <name>A0A2H3JRP8_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RanBP2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WOLCODRAFT_152606</name>
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    <organism evidence="7 8">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468124">
        <property type="protein sequence ID" value="PCH42573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JRP8"/>
    <dbReference type="STRING" id="742152.A0A2H3JRP8"/>
    <dbReference type="OrthoDB" id="79830at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.10">
        <property type="entry name" value="Zinc finger, RanBP2-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00641">
        <property type="entry name" value="Zn_ribbon_RanBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RanBP2-type" evidence="6">
        <location>
            <begin position="897"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="6">
        <location>
            <begin position="975"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="344"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="439"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="477"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="497"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="535"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PCH42573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="1003" mass="109157" checksum="71E4920436DAC785" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JRS9</accession>
    <name>A0A2H3JRS9_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WOLCODRAFT_141211</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467987">
        <property type="protein sequence ID" value="PCH39364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JRS9"/>
    <dbReference type="STRING" id="742152.A0A2H3JRS9"/>
    <dbReference type="OMA" id="ANIREKC"/>
    <dbReference type="OrthoDB" id="1274115at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05374">
        <property type="entry name" value="17beta-HSD-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051911">
        <property type="entry name" value="SDR_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976:SF16">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PCH39364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="289" mass="31809" checksum="DC43876EC8115370" modified="2018-01-31" version="1">MDPSRKVWFITGTSSGLGRCLVSSALARGDCVIATVRHLEDFALPDVDRSRLRVVVLDVTDTEENIQTAVDDALTFWGRVDVLVNNAGYASKCMVEEGRSSAAIAQFHTNFFGALKVTNAVIPHMRQRRSGTLVFLGSRSVWQANVPAVGFYIASKAAIHAMSECLAAELAEFGIRILLIAPGGFRTGSNDRISYTMNRHVPAYDGTRENVLKNLDEYWKHAKGDPAKAMEVLVDVVRSEGKAKGRELPGFLLLGNPAYVQGRAHCEQMVQNMDSWEDIAKDLDFDSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JRZ8</accession>
    <name>A0A2H3JRZ8_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_25502</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468124">
        <property type="protein sequence ID" value="PCH42683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JRZ8"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH42683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="71" mass="7521" checksum="DC17740476892C3B" modified="2018-01-31" version="1" fragment="single">VPRDPPARAAYEAVYVPAQAAHARPQPICRRHSVPRSTGCSGFVQMGSAAVHFLIAPPSSVSNRCQPRLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JSH8</accession>
    <name>A0A2H3JSH8_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_165599</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468168">
        <property type="protein sequence ID" value="PCH45096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JSH8"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH45096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="177" mass="17981" checksum="5119663E8698E4DF" modified="2018-01-31" version="1" fragment="single">MRAIGRLRRAGNVSLSSPRRRASPPRSLAGPRRRPADWLHAGQPMGDGDPPGRDGRGMQIGGDGAVGSVDGAGSAMILSGGRRTCCSRLGAGPPWSLGAVAPGSPVGTIAVGDDAGIAPMTVRAAGDGRRRHGGRGGRDAVDDGPGGRVAAARSRPPRINARRLGANRGGAYISWEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JSV5</accession>
    <name>A0A2H3JSV5_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WOLCODRAFT_139087</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468157">
        <property type="protein sequence ID" value="PCH44595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JSV5"/>
    <dbReference type="STRING" id="742152.A0A2H3JSV5"/>
    <dbReference type="OMA" id="KSAPYAI"/>
    <dbReference type="OrthoDB" id="6509908at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
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    </dbReference>
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        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF234">
        <property type="entry name" value="MFS-TYPE TRANSPORTER DBAD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
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            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
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            <begin position="310"/>
            <end position="330"/>
        </location>
    </feature>
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        <location>
            <begin position="337"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="363"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="401"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="429"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="276"/>
            <end position="463"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
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        <location>
            <begin position="29"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="50"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PCH44595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="463" mass="49271" checksum="038A6A995AE7D75A" modified="2018-01-31" version="1">MSAVSEVDAVTTVPEASDLDGPTRAPSADNHDSEKRIERRSSDDNASMSKGKEDGGAHDGEHAHLSFPDGGLRAWLVALGVGCGIMATFGFVNAWGVFQAFYEETMLPDTSPSTIAWIGSVQYALVFIPGLIFGRLFDMGYFKGPLFVASSLLVASTFLVAQCTQFWQLILCQGLAVGFTSGAIFGPMMGILPHWFHKKLGIAYGLTATGSSLGGTLFPIAVRNLISQVGFPWTMRIVGFILVFLLGICNLTVDRRLPPKPRSGPFINLRAFKTPSYAVYSASAFTSFLGLYTVLTYIDVSAAAAGITENFSFYLLPIANAGSLIGRVLGGICADRFGPLNVITPATFVAGIMTYAWPYSGSVGGYVIVAILYGMSSGVYASLVASPIVHMGERWDVGTRVGMSFTLLALGALAGPPISGAIYDATGNYRAVGFYAGSTVELAVVLLLISRHFVLKGKFWGRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JTE9</accession>
    <name>A0A2H3JTE9_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PIN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_70725</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH41108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="742152.A0A2H3JTE9"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:RNA nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="PIN_Swt1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052626">
        <property type="entry name" value="SWT1_Regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16161">
        <property type="entry name" value="TRANSCRIPTIONAL PROTEIN SWT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16161:SF0">
        <property type="entry name" value="TRANSCRIPTIONAL PROTEIN SWT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13638">
        <property type="entry name" value="PIN_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="196"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH41108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="353" mass="40300" checksum="9E1065A85872652B" modified="2018-01-31" version="1">MYLVLDTNVVIDHLDVLKWFSKDVEALGLRIKIVVPHVLLSELDGLKGSKSLGWFARQASGWILDRMRESKTVKVQARKETLHTPLDPVRKNDVAIYDCAKFFQQTGYVVLVSRDNNLLLDGFSNDVPTVCPPRRGWSSRDLARGIAQELAHFGVPVFLDVSKFRGHDHTPVYRPSRGSRELRTTMPPKSEGDGDDRMDVDDDGFHNEYIPSHALDALHLQVIDHFTPMLKDLAARVRTSTGDSVEQELSRHAPWYRRKGFDTWTVGDCLEYLGSKKRLLVTSPSLRVFLLGRSEDRGWRRGQDWSHQDWQNAMTALQDVGTKFEDRSTLISLGYLKLETERVFKTPMRPTGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JTU2</accession>
    <name>A0A2H3JTU2_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zinc-finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_138306</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468146">
        <property type="protein sequence ID" value="PCH43383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JTU2"/>
    <dbReference type="STRING" id="742152.A0A2H3JTU2"/>
    <dbReference type="OMA" id="QCNRKRD"/>
    <dbReference type="OrthoDB" id="298344at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="452"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="616"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="192"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="639"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="662"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="679"/>
            <end position="692"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH43383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="739" mass="81095" checksum="EE488D1E3CD25BFA" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JU48</accession>
    <name>A0A2H3JU48_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_165598</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
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            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
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                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
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                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
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                <person name="Kumar T.K.A."/>
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                <person name="Lindquist E."/>
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                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
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                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468135">
        <property type="protein sequence ID" value="PCH42858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JYB7"/>
    <dbReference type="STRING" id="742152.A0A2H3JYB7"/>
    <dbReference type="OMA" id="MINPRTH"/>
    <dbReference type="OrthoDB" id="3267098at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH42858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="204" mass="23937" checksum="232B0A801D9FAF34" modified="2018-01-31" version="1" fragment="single">NFIPLLKNHLLSRLMGREFDGDENEFTPEEHATLKILENKIYFHKVVRVNYTTYDMRRDQDMINPRTHPDVMVLAHEDDQDHNANTHPYWYVRVIGIFHVMVEHTGIYSTSKRPRRMDFLWVRWFGRDLSALGGFQTHRLHCIGFVPDDDRNAFGFLDPDNVLRAAHLILAFADGHTDRLLGSSGACQIHGEDDMDYENYYVNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JZ20</accession>
    <name>A0A2H3JZ20_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_24710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH41397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JZ20"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH41397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="133" mass="14581" checksum="BAA313DCD3F6121D" modified="2018-01-31" version="1" fragment="single">MKCDAKHSGHAACGYNFQLQDLRPGWSTSRLASNERAGSSPGVVLPCEQPACIYEILTSKRALPVVMTGKPGRANPALGIHYGQDQSGTRTLHPMAGVQGAEVRHRRHCRLGHEIWRFRACLKSPPEELKGII</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JZ24</accession>
    <name>A0A2H3JZ24_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_119773</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468124">
        <property type="protein sequence ID" value="PCH41984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JZ24"/>
    <dbReference type="STRING" id="742152.A0A2H3JZ24"/>
    <dbReference type="OMA" id="ISCNDES"/>
    <dbReference type="OrthoDB" id="3228837at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF17">
        <property type="entry name" value="FUNGAL STAND N-TERMINAL GOODBYE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="2">
        <location>
            <begin position="43"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH41984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="415" mass="47003" checksum="B60458479AABFBCB" modified="2018-01-31" version="1" fragment="single">MRDRDVQVVLDRLPHRDHAEYRSAINEAKNGYLPGTRMDLLTTLERWATAPEQPCIFVLSGAAGTGKSTVAYEFAKRLDGIGRLGASFFFVRGDANLSCTTYVIPTIAYQLARSQVAIRACVVEHVRSHLSRGDLQSMEAQVQDLIARPLSVATADCNPVVIIIDALDECMDQALERIPRLLYLLLRGIRDLHIPIRIFLTTRPELHIERVFETVEFKSVTKSYRFEEVPQVNVDGDIALFFWDRLARLPTSRLLFDSRPNVVQDLTKRAKGLFIWAATACRTLDRNSRRIIQLIDALLDNSENSLVVLNDLDTLYLTVLRSALPSEFLNEWHENRAAMEQVLGALALLRDHISPNALAALLDVAEEGILSILERLQSVSHYDRSDSTVPFRPLHASFPQFLVDNQRCQDTCYYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K278</accession>
    <name>A0A2H3K278_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WOLCODRAFT_152533</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB468124">
        <property type="protein sequence ID" value="PCH42497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K278"/>
    <dbReference type="STRING" id="742152.A0A2H3K278"/>
    <dbReference type="OMA" id="FMPTFQV"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF564">
        <property type="entry name" value="STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="9"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PCH42497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="323" mass="35746" checksum="E9CAEC41F412ED7C" modified="2018-01-31" version="1">MPVAASGKILVTGANGYIGAWVVRTFLEQGYSVRAALEFAIVADITQEGAFDEAAKGIDAIQHIASPVIPDGNDPQELIGPAVNGTLGILESARVHGDTMKRVVVTSSCGAVIEYSDKPRRFSEADWNEQAVTEVQEKGKAADSLFKYYASKVLAERAAWEYVEKHRDELRWGLVVINPHYTYGPVIHDVNSPDELTVTMDSWYRCVLKDINGPQLYRTADGSEWADVRDVAHAHVLAVQKPEAAGNRIIVSQGPWKWEDWIIAARHCGAATCPVDESYDSANAVRMVTYDTSRAARLLGMKYRSIQECTSDIVADFRARRWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K3I0</accession>
    <name>A0A2H3K3I0_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_18059</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468135">
        <property type="protein sequence ID" value="PCH42967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K3I0"/>
    <dbReference type="STRING" id="742152.A0A2H3K3I0"/>
    <dbReference type="OrthoDB" id="10253736at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321">
        <property type="entry name" value="DEHYDROGENASES, SHORT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321:SF8">
        <property type="entry name" value="ESTRADIOL 17-BETA-DEHYDROGENASE 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH42967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="260" mass="27809" checksum="67DB8C39C4BFCBA5" modified="2018-01-31" version="1">MDYGLKNVHALITGASGGIGLAAAEPFLRLGAKVTAHYNLNVRSLEPLTSQYGCRRIQAAQANLTQEADVIRMFEQTKAEFGNIDGCKNVPGSAEHDDEHESYFVIPCSKGISESTKDKASIVLVGSTAGKFGSLGHADYSASKSAMMYDIMLALNNEIVNIAPRRHINCVAPGLTQTSCTMGDREKKYSVLATRIMGSSLRKIVPTEDVAAQIVSLSSFAVSGHVTGQILMVDSGLEGMVTRHCRGKAIFGPSSNEHNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K3N6</accession>
    <name>A0A2H3K3N6_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_124067</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468168">
        <property type="protein sequence ID" value="PCH44768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K3N6"/>
    <dbReference type="STRING" id="742152.A0A2H3K3N6"/>
    <dbReference type="OMA" id="HNAMIAS"/>
    <dbReference type="OrthoDB" id="78858at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019152">
        <property type="entry name" value="DUF2046"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15276:SF0">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15276">
        <property type="entry name" value="H4 D10S170 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09755">
        <property type="entry name" value="DUF2046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="226"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH44768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="378" mass="41084" checksum="1B5F58A7205FA4C2" modified="2018-01-31" version="1">MSVSPPIRRYSSTSSSSREDLINQYEAEEERIVNLLSRKLERLREEKITLENTLEAESESHVNRLSREISALRLAQQQAQVNGNGSGSGSPVDSRVGLHSLYKSFLDPSPEMMLEAMRRENEQLRARLVDTERDYVRISRLNEIYREELIEHRRRLGLSVDNLIGLSPADPYSQPTHRRTGSTTSGSASVLAVPSPQRSQPARSTTAVPIPRPPSQIHRPAATGISDSESNTPLSSSSSSPYPFSPSSVSPLPASVTTAATSPPSSAPLAFLPVPGTANSTLSYPSVPPPSLSSSFGSPEAMHRRGSLDRRVAETGSLRSPSRGSRHGSVERGARLAETGILLPRGRVGRESLREEIEDAVETTHADTINGLTNSHRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K473</accession>
    <name>A0A2H3K473_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_90552</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468146">
        <property type="protein sequence ID" value="PCH43844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K473"/>
    <dbReference type="OMA" id="RICGYER"/>
    <dbReference type="OrthoDB" id="2637653at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH43844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="144" mass="16151" checksum="179D17FEACD61C9C" modified="2018-01-31" version="1">MSCTEWLVFEGISAFILELTVQLILILRLYAMYSGTRHIQRILLVPFAVEVCVMATTLGVSIPRIMTTPDCIEASLPIEMAVYCITAIAYECLLLYLTVSRYFYARRNGWGNIPLMTILIRDGVWGFALVFGNAVLSLLEMATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K4B8</accession>
    <name>A0A2H3K4B8_WOLCO</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_155042</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468168">
        <property type="protein sequence ID" value="PCH45018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K4B8"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="21"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="63"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="42"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH45018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="268" mass="30779" checksum="BE730DC37A68BE21" modified="2018-01-31" version="1">MPKDTSCGIGKYVLAKHDPTGRTERWEVPSPLPPHIAAVGKPIRKSRKGTKPYKPRERSPGELAELSAEMQEYHKQCAELNKLMAQRREIEKKLAAKRRALKTVPLEQRLSSPVQGPSVPDNHHILNPSLQFGKTIYLRAAEHIRSTLLATLTRLTPLYNKGRNYSNYDAYYDIKFDQMVIQLDDLLEHLRERARSGRITRKMWRVMKTDCNRIGRVSLERMDQRMAEIIKELAELKISFEYGVPEPEKVTGSSTVTTVDEDILMSIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K4E0</accession>
    <name>A0A2H3K4E0_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WOLCODRAFT_91112</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB468168">
        <property type="protein sequence ID" value="PCH45038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K4E0"/>
    <dbReference type="STRING" id="742152.A0A2H3K4E0"/>
    <dbReference type="OMA" id="WPLEMAQ"/>
    <dbReference type="OrthoDB" id="2309723at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF29">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="6">
        <location>
            <begin position="136"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PCH45038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="579" mass="63205" checksum="959325C64F90020F" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K4K3</accession>
    <name>A0A2H3K4K3_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_155105</name>
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    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Basidiomycota</taxon>
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            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468168">
        <property type="protein sequence ID" value="PCH45098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K4K3"/>
    <dbReference type="STRING" id="742152.A0A2H3K4K3"/>
    <dbReference type="OMA" id="IIRWCES"/>
    <dbReference type="OrthoDB" id="3071736at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH45098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="96" mass="11019" checksum="3D6DC56A34BF5587" modified="2018-01-31" version="1" fragment="single">SLFAALALKRRRKKKLVIAGVLAGAGAGAAEQARRYENVVRWCRGFGETRKIERREDGSLHVYWKEWEVADRVCRVQAQVYIKDVGRVSLAWHYTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K4L9</accession>
    <name>A0A2H3K4L9_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">APG6-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WOLCODRAFT_121832</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="174"/>
            <end position="305"/>
        </location>
    </feature>
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        <location>
            <begin position="308"/>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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    </feature>
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        <location>
            <begin position="67"/>
            <end position="80"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
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                <person name="Lucas S."/>
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                <person name="Martin R."/>
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                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
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                <person name="St John F."/>
                <person name="Stenlid J."/>
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                <person name="Syed K."/>
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                <person name="Wiebenga A."/>
                <person name="Young D."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">MD-104</strain>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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        </location>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH44254.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="315" mass="33417" checksum="50DB3E60067C2E1E" modified="2018-01-31" version="1">MRRIDLNAAAASSTLSPALISLRMLSVGVGISLGLLLVPALSMQSHHWRRRRSFVMGNFFMGFESTGFVCGVRAAVFMMLVLFVINNSLLTTRHNLLPTSACSSASGASSSRLFVNAHRLSSTLVFLTVRAPSPLVRLGSANRSLSADRDLVFVTFAAANKSAVIVFAIFFGAFSGAFISLLPTMLASMSRGPTEMGCVPRSLSLSPLPFILAGNTVGGASGECAGKWWAEAGAEPSQDDAQLVPATPHAEAVWARTLHLQTCSGAAWVRDCRATILGCTQGRLYLFPPLALSRIWAMLGLGGEMHAASSNKLAR</sequence>
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    <organism evidence="2 3">
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
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                <person name="Martin R."/>
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                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
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                <person name="Stenlid J."/>
                <person name="Sun H."/>
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                <person name="Wiebenga A."/>
                <person name="Young D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="32"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH44594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="333" mass="37103" checksum="9F58B333210A2B67" modified="2018-01-31" version="1">MGESDSKSNVSSSVSAKAVDFTPSNDVWYIDGSVVLVTEKTAFRVHGTIMAAHCEIFKDMFAMPQPAISDPDTETYDGCQVLRLQDSPANMKHFLKAIYDFSYFQPGTKTKFPIIAAVVHLSTKYEAAGLRQRAIDLLATAYPSTPAAWENRSAQRLVPPFEGEHAAYIALATENDIRVILPTVYYSASRQPLAEVMAELRKVSLAPNWEIFADFVVGREQLFRAELKHILAFLDVGFTRPQCQNTSVCTNVLGNARNHILQKITDAEPFHQWCNANSCEVGRTLGLCNICCTTIENSIKEGRKKVWEQLPRMFGLGDWETLRARDGLNGNGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K7P7</accession>
    <name>A0A2H3K7P7_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">5'-deoxynucleotidase</fullName>
            <ecNumber evidence="8">3.1.3.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">WOLCODRAFT_139023</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the dephosphorylation of the nucleoside 5'-monophosphates deoxyadenosine monophosphate (dAMP), deoxycytidine monophosphate (dCMP), deoxyguanosine monophosphate (dGMP) and deoxythymidine monophosphate (dTMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyribonucleoside 5'-phosphate + H2O = a 2'-deoxyribonucleoside + phosphate</text>
            <dbReference type="Rhea" id="RHEA:36167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18274"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:65317"/>
            <dbReference type="EC" id="3.1.3.89"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the HDDC2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.89" evidence="8"/>
    <dbReference type="EMBL" id="KB468157">
        <property type="protein sequence ID" value="PCH44457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K7P7"/>
    <dbReference type="STRING" id="742152.A0A2H3K7P7"/>
    <dbReference type="OMA" id="TWRLCLM"/>
    <dbReference type="OrthoDB" id="10254258at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002953">
        <property type="term" value="F:5'-deoxynucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009159">
        <property type="term" value="P:deoxyribonucleoside monophosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3210.10:FF:000011">
        <property type="entry name" value="HD domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039356">
        <property type="entry name" value="YfbR/HDDC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11845">
        <property type="entry name" value="5'-DEOXYNUCLEOTIDASE HDDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11845:SF13">
        <property type="entry name" value="5'-DEOXYNUCLEOTIDASE HDDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13023">
        <property type="entry name" value="HD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0170">Cobalt</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="13">
        <location>
            <begin position="37"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PCH44457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="226" mass="25785" checksum="C719E31355BBB9F9" modified="2018-01-31" version="1">MSAALHDAATPGKRVFPPLYVSDGNMSVDRLAFFHILERLKTQKRTGWIDHNIPGSESISDHMYRMAVLAMCTSDTKLDISKCVMMCLVYDLAEAQVGDIAPREGIPKAEKRRLEAEAMHNFVHEMLHNNPAAQRIEALWQEYEDGQTKEARFVKDLDRFEMASQALEYERAHNAQLQTFFESSLPNIRHPEVQEWGRDLLDERERLVLGYNGTIDGDEGQIAGDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IT03</accession>
    <name>A0A2H3IT03_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_134926</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH33110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3IT03"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH33110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="145" mass="16040" checksum="82B7EC1E2BBCD0A6" modified="2018-01-31" version="1">MEQRRRTGADVAHWQLVNTDSAQYRMKLLLSDVGVTEHRWSMCSFSWVELIGTDSGAALWHAAIGHFIDMDCDRLNARSCGNVASSLLSASGAVGCLAAYVVYRLKSVCQGSLAACNCITGYHLEPTNINEERDIESPLIRWPIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IT15</accession>
    <name>A0A2H3IT15_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dynein heavy chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_93003</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the dynein heavy chain family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH33132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3IT15"/>
    <dbReference type="STRING" id="742152.A0A2H3IT15"/>
    <dbReference type="OMA" id="NQYDTAR"/>
    <dbReference type="OrthoDB" id="447173at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005858">
        <property type="term" value="C:axonemal dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013594">
        <property type="entry name" value="Dynein_heavy_tail"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46532:SF4">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46532">
        <property type="entry name" value="MALE FERTILITY FACTOR KL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08385">
        <property type="entry name" value="DHC_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynein heavy chain tail" evidence="2">
        <location>
            <begin position="251"/>
            <end position="813"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH33132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="1178" mass="134957" checksum="9AB6448E449BA54B" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IU82</accession>
    <name>A0A2H3IU82_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ras-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_22073</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH33540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3IU82"/>
    <dbReference type="STRING" id="742152.A0A2H3IU82"/>
    <dbReference type="OMA" id="GGPNKTC"/>
    <dbReference type="OrthoDB" id="63533at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01860">
        <property type="entry name" value="Rab5_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000808">
        <property type="entry name" value="Small GTP-binding protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="132"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="222"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="134"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="153"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="222"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="243"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH33540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="253" mass="26817" checksum="72A7DDA7AB449CD5" modified="2018-01-31" version="1">MADGASGSAERSVQVKLVLLGEAAVGKSSVVLRFVSNEFQANKEPTIGAAFLTQKCRLEDRVLRYEIWDTAGQERFHSLAPMYYRNAQAAVVVYDVTKASSLEKAKTWVKELQRQANPNIVIALAGNKVDLVQPSSSSPASPSPEGEEEADDATATPGEGAAAEPESLRQVPREEAEAYAQEAGLLFFETSAKTGEGIVEIFTEIAKKIPIEQILASSRGAGRAGAAGGRTSGQEGAVNLEENASKGRDACNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IUX4</accession>
    <name>A0A2H3IUX4_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal protein S28e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WOLCODRAFT_93616</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS28 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH33511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3IUX4"/>
    <dbReference type="STRING" id="742152.A0A2H3IUX4"/>
    <dbReference type="OrthoDB" id="10258930at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04457">
        <property type="entry name" value="S1_S28E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000025">
        <property type="entry name" value="40S ribosomal protein S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000289">
        <property type="entry name" value="Ribosomal_eS28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10769">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10769:SF3">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN ES28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01200">
        <property type="entry name" value="Ribosomal_S28e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PCH33511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="104" mass="11599" checksum="6A3C33B75B85A9C2" modified="2018-01-31" version="1" fragment="single">MDSSSKAPVKLATVIKVLGRTGSRGGVTQVRVEFMDDPSRTIIRNVKGPVREKDILALLESEREARASGEVPALSLDPVSPIWLCFYLYDHPNAMRMRLSRQLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IVA4</accession>
    <name>A0A2H3IVA4_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10 13">Catalase</fullName>
            <ecNumber evidence="3 10 13">1.11.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">WOLCODRAFT_129730</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the degradation of hydrogen peroxide (H(2)O(2)) generated by peroxisomal oxidases to water and oxygen, thereby protecting cells from the toxic effects of hydrogen peroxide.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2 H2O2 = O2 + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10 12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 10 13">Belongs to the catalase family.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.6" evidence="3 10 13"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CATALASE"/>
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    </dbReference>
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        <property type="entry name" value="Heme-dependent catalase-like"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10 13" id="KW-0349">Heme</keyword>
    <keyword evidence="9 10 13" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="8 10 12" id="KW-0408">Iron</keyword>
    <keyword evidence="6 10 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 10 13" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catalase core" evidence="15">
        <location>
            <begin position="42"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="380"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005329"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012314"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU004142"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH33365.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
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    </evidence>
    <sequence length="746" mass="82742" checksum="6794A84A7210A37D" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IVH0</accession>
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    <protein>
        <submittedName>
            <fullName evidence="2">Dehydrogenase</fullName>
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    </protein>
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        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
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                <person name="Stenlid J."/>
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                <person name="Sun S."/>
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                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
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                <person name="Eastwood D.C."/>
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            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
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        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
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    <evidence type="ECO:0000259" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH33721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="346" mass="36875" checksum="8406916E555A050F" modified="2018-01-31" version="1">MHALVTNGDGTFDLKQVPIPTPGPNDVLVKVAAIAQNPTDWKTALLHQRKGNILGCDFAGTVVGIGSNVEPGLRKIGERIAAIVHGGVSPNGAFAEYVVTDATIAIPIPDDMSFEIAAQLPVACYTTCQCLYQCLNLPTPLEPTKEPIDVLVWSGTSATGQYAVQFAKAAGLRVISTASARNIEFVKSLGADEVFDYADSHTPRKIFAATGGKLRHVVDCISEGRTPNQCSMSLSKEGGTITTLLPYTSRSKGVKTDFVLAYSIFGNPVEFPFVFPASEEHHKNAGQYAKLIAEVIAKIPIKSIPVNIFPNGLLSVADGFEYMKAGKVHAEKITYRIADTPGLSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IWP7</accession>
    <name>A0A2H3IWP7_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WOLCODRAFT_94335</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH33855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3IWP7"/>
    <dbReference type="STRING" id="742152.A0A2H3IWP7"/>
    <dbReference type="OMA" id="RDEPRMM"/>
    <dbReference type="OrthoDB" id="10256233at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47960">
        <property type="entry name" value="DEAD-BOX ATP-DEPENDENT RNA HELICASE 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="97"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="484"/>
            <end position="636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PCH33855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="636" mass="69783" checksum="E42DC981533861AC" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IWZ6</accession>
    <name>A0A2H3IWZ6_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WOLCODRAFT_135736</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH34476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3IWZ6"/>
    <dbReference type="STRING" id="742152.A0A2H3IWZ6"/>
    <dbReference type="OMA" id="IEECLGP"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000275">
        <property type="entry name" value="SRSF protein kinase 2 isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="47"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PCH34476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="415" mass="46006" checksum="63BD60BA37068859" modified="2018-01-31" version="1">MPSSHVSNKSGHSSSGSLGGFPEEDLRSAGRSYFPARLGQTLERGRYCIVRKLGWGQYSSVWLARDREEDRFVALKILTCEATKALSGRETEQRSDELALLQRIADAEPSHPGFRHNIAYCGSFAFAGPRGAHRCVVTEALGYSLDHIRKLRDDGDRRVRPSIVKRVVKQVLRGLQYLHDVCGIIHTDIKHDSILFRPADIAALAAHALATDPSVAYDCGTEACPPVVPVESQALPLSAAPPVREDALEAVLADVGHSHWRHRHFQEVIQPAALRAPEVILGYAWDTPADIWSVGCIVTELLVGFWLFKASAGRGWGVEEDHLARMTEALDTSFAVGFLDKCAHNSKFFNADGSFAHFTQHDEPTWQIRRLLESFSLLQDAAEVDVAERFILRCLRLVPEERAMAGELADDPWLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IX00</accession>
    <name>A0A2H3IX00_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WOLCODRAFT_135743</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD-104</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH34492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3IX00"/>
    <dbReference type="STRING" id="742152.A0A2H3IX00"/>
    <dbReference type="OMA" id="AMAIYEM"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050665">
        <property type="entry name" value="Cytochrome_P450_Monooxygen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24282">
        <property type="entry name" value="CYTOCHROME P450 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24282:SF228">
        <property type="entry name" value="CYTOKININ HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 9" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PCH34492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="128" mass="14301" checksum="31C7BB2048EAB1F1" modified="2018-01-31" version="1">MRELHIPKGVEVVIGTLGCNAKKSLWGEDTLVWKPHRWMSPLPTAVSNAPIPGVYSNIMTFLGGKRACLGFKFSEMEMKVVLSVLVSKFTFELSDKPVQWNVGTVWYPTVGMESKPRMPLKVSLYKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IY27</accession>
    <name>A0A2H3IY27_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Amine oxidase</fullName>
            <ecNumber evidence="14">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">WOLCODRAFT_27512</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a primary methyl amine + O2 + H2O = an aldehyde + H2O2 + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16153"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:228804"/>
            <dbReference type="EC" id="1.4.3.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <cofactor evidence="14">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="14">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <text evidence="13">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="PTM">
        <text evidence="13 14">Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the copper/topaquinone oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="14"/>
    <dbReference type="EMBL" id="KB467832">
        <property type="protein sequence ID" value="PCH34866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3IY27"/>
    <dbReference type="STRING" id="742152.A0A2H3IY27"/>
    <dbReference type="OMA" id="QDGNIEC"/>
    <dbReference type="OrthoDB" id="5379943at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008131">
        <property type="term" value="F:primary methylamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009308">
        <property type="term" value="P:amine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.20:FF:000006">
        <property type="entry name" value="Amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.20">
        <property type="entry name" value="Copper amine oxidase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049947">
        <property type="entry name" value="Cu_Am_Ox_Cu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049948">
        <property type="entry name" value="Cu_Am_ox_TPQ-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000269">
        <property type="entry name" value="Cu_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015798">
        <property type="entry name" value="Cu_amine_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036460">
        <property type="entry name" value="Cu_amine_oxidase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016182">
        <property type="entry name" value="Cu_amine_oxidase_N-reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015800">
        <property type="entry name" value="Cu_amine_oxidase_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015802">
        <property type="entry name" value="Cu_amine_oxidase_N3"/>
    </dbReference>
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                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
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                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
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                <person name="Benoit I."/>
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                <person name="Gorecki P."/>
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                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
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                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
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                <person name="Larrondo L.F."/>
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                <person name="Morgenstern I."/>
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                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="508" mass="56930" checksum="90A25C0BFBE7E5F7" modified="2018-01-31" version="1">MAVKHPFSPARRDGRRRLSPIPVDIYMLVLDELLRDEEDMCASRRKSLLSSLSLVCRLFAALVAPRLFSSLACSGPLFKQTKKSPPRLSWLQQLNRGEETACWTGTLVRKLDFCDWELGKAGLSDYLAHLTHHIQAIPKLPNLTSLSLTRTPITQQFFQAVSALQKLDSLCIRECSCQPPDTAMAPPESPMPRLGSLEVTAVEGVKPYIAILVSLAGTPALRSLKTTEWPVARPIMERNTCTSLQQLEVPFVARDIAFLTSFLADTPSISELSIIDVDQQPPAPPVSFPAISLPLLQRLRCPPYLLPSVSHPSVSQLSLVSLNDWMLPGVSIDQRLLAPLRRATLRELELPAHLLRDCPIGEYAPKLAKLTICYPVTTFNEPLELIVRNVCTLVHRVPLQSLELEFVNVLWKLNLQLQHHMVVRHLAPTYPTVKRVSLTDAVEWHRSKDGSQWTPVIRNRDSVKLLLGLKDANIWEAMEVQDFDGALSALFEKGEMTADIAQRLSRQR</sequence>
</entry>
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    <accession>A0A2H3J2H7</accession>
    <name>A0A2H3J2H7_WOLCO</name>
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    <gene>
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        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
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            <taxon>Phaeolaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
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        <property type="protein sequence ID" value="PCH36432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015218">
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:pyrimidine nucleotide import into mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="MCP_dom_sf"/>
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        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049562">
        <property type="entry name" value="SLC25A33/36-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45829">
        <property type="entry name" value="MITOCHONDRIAL CARRIER PROTEIN RIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45829:SF4">
        <property type="entry name" value="MITOCHONDRIAL CARRIER PROTEIN RIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
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        <property type="match status" value="3"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
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        <location>
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            <end position="131"/>
        </location>
    </feature>
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        <location>
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        <location>
            <begin position="239"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH36432.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="328" mass="35764" checksum="CB81BC5CB117414B" modified="2018-01-31" version="1">MSDTLPQPVASSSKPSVLPSKSWQHFVAGGLGGMCGAIVTSPFDVVKTRLQSDLFQVKVKSASLGLAGNGTVVAPHRTNLLWHFVETGHILRDIYREESFRALFRGLGPTLVGVIPARSINFFTYGNGKHIIANYFNNGQENSWVHLSAATCAGIATGTATNPVWVVKTRLQLSQSSGERLVGGSWDMIKQIFRQEGIRGFYKGLSASYLGVTEGTIQWTLYERLKRITAGTEGKGGVQEWLGMLGSAGTAKCVATLITYPHEVIRTRLRQPLVDGKMKYTGLWQTLRLVIAEEGAKSLYGGLSAHLMRVIPNAAVMYSIYEAVLRFA</sequence>
</entry>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
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                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
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                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
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                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
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                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
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                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467887">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH36536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="84" mass="8851" checksum="2AC28CDD3F42A50F" modified="2018-01-31" version="1">MTLLPGHSASQLLRVGVKEEVHLSIRNLRSLSQDGGRIYVARVTACGEYAAPASPEVPAEGGQAPRPCPMTMNAFICNGMLGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J3A1</accession>
    <name>A0A2H3J3A1_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
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    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_140558</name>
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    <organism evidence="3 4">
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
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                <person name="Ling A."/>
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                <person name="Sun S."/>
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                <person name="Wiebenga A."/>
                <person name="Young D."/>
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                <person name="Martin F."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
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    <sequence length="476" mass="50285" checksum="241B408826F476BA" modified="2018-01-31" version="1">MSSIPALYNISLSDQSAFLRFFPQRDGPLNTMWNVTYSGSNYADWSTSNNFGIGTSSHNTTFIGAYLLVDWTGTGIWFDGTMEDGAYTVQIDDGSSTVGTGATNGVLFGQDGLPYGPHQANLTVIKNNTVASITGATITVGMGEPGTILEQRTINTTIEQFQITGNPFFSANGTGWSPEILYTDQQHSYPCIETNQVGSTVSFNLNESVGFALYGSDDYQQGLFTVNVTIPGQPTPSYLPNASTQRYSPKSQWTALNQLKFLATGMNRSETYNVVITNTGSTFNLASVVAYDAVPNATASSSSTSSKPTSSAGAVSTSRAQSHSVKGGVIAGATIGAVLAVAIVSALIFLATMRRRRHRANLEAALALPTSYPKPEEGYAPAPTQSPPTIPVPLSEKRSRHVFTLPTTLSVGETSASAHPSSSSQVPSASVNPPTIPGTRTYTAVDSDIHEVDAGPLTQPPVYDPAWAESSVALNS</sequence>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
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                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
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                <person name="Martin R."/>
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                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
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                <person name="Ruiz-Duenas F.J."/>
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                <person name="Stenlid J."/>
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                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
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            <dbReference type="DOI" id="10.1126/science.1221748"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">MD-104</strain>
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    </reference>
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        <property type="entry name" value="TIGR02452 family protein"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="26"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH36645.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
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    </evidence>
    <sequence length="343" mass="37902" checksum="EC25318524726F0D" modified="2018-01-31" version="1">MAMRRRSSRATATAVLPPFTTIPVAHDISMMIMLSRQGTSFYPHYSELLAMWAQNRPAIPRFKTRIVFNSISTLSAAHQLALSREPGAPRATVGVLSFASPKQPRGQFLQGGDEQEETVARLSSLETNLTSPAAQEFYREHRKYRAEDGSGLHDHSMVYSPGVVVFRRDSGDMLALVGEDSTATATILPRTEDPSAGEFIAPYTVNVVSAVPVHAGTVRSKHIILPSEKQLFDSGMRQVMKERMARALRLFEERRDHTVVLGAFGCGQSQNKADAVAGIWAELLVCGWIDEEGKKRPARFADSFEKVVLAVPGKWFADFKRAFDMRIFEERVAEAALTNSSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J5K7</accession>
    <name>A0A2H3J5K7_WOLCO</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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        <name evidence="1" type="ORF">WOLCODRAFT_109456</name>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Barry K."/>
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                <person name="Jurgens J.A."/>
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                <person name="Nagy L.G."/>
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                <person name="Rokas A."/>
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                <person name="Sabat G."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467898">
        <property type="protein sequence ID" value="PCH36955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J5K7"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH36955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="124" mass="13847" checksum="FEB2571C5E701439" modified="2018-01-31" version="1" fragment="single">MCSIYQMKCFRRTLVTVVVSLTGKANVWTVPARTDDPVLHCHKRQSQSVVNQYGTFLPRFSDSCGGITGDFEAPHIFASQGVLCRRQPQEVLWAVIVMVCLSLGQTDKTPLSANLTNFHCVSHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J656</accession>
    <name>A0A2H3J656_WOLCO</name>
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    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
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                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
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                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
            <location evidence="7">Cytoskeleton</location>
            <location evidence="7">Actin patch</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the WD repeat ARPC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH37732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J656"/>
    <dbReference type="STRING" id="742152.A0A2H3J656"/>
    <dbReference type="OMA" id="YVWEPSP"/>
    <dbReference type="OrthoDB" id="406844at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017383">
        <property type="entry name" value="ARPC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10709">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10709:SF2">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2_3 COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038093">
        <property type="entry name" value="ARP2/3_su1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="51"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="300"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR038093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PCH37732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="404" mass="43025" checksum="763F62BDE18F4A0C" modified="2018-01-31" version="1">MSPPEVYSLAQTSITSHAFNADRSEVAVSLNTKDVTIFAREGHEWKATETLSEHDKIITSIDWAPNSNRIVTSSQDRNAYVWQLSPDPQTGRMIWKPTLVLLRINRAATHVRWSPNEDKFAVASGARAIAICSFDPEGDWWVSRLLKKPIRSTVLSVDWHPNNVLLAAGSADMKARVLSAYIKDVDKKPSPTVWGEKLPFNTICGEYTSPTGGWVHAVGFSPSGDALAFASHDSCITVVYPGGPAAFTIKLTSLPLLTLTWTTENSLVAAGHDCQPIVFSGSEGGWELTGSLDDPHSNKSSGGSRPGAPAAGRLNSAAFNTFRNADSRGISSGPGSAAAPATESELFTVHQNTITSVRLYAGVPGNVTQVSTSGADGKLVVWDVNQVTPASATGLAGKMAGLRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J6J1</accession>
    <name>A0A2H3J6J1_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">H/ACA ribonucleoprotein complex subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Nucleolar protein family A member 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WOLCODRAFT_148830</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Common component of the spliceosome and rRNA processing machinery. In association with the spliceosomal U4/U6.U5 tri-snRNP particle, required for splicing of pre-mRNA. In association with box C/D snoRNPs, required for processing of pre-ribosomal RNA (rRNA) and site-specific 2'-O-methylation of substrate RNAs. Essential for the accumulation and stability of U4 snRNA, U6 snRNA, and box C/D snoRNAs.</text>
    </comment>
    <comment type="function">
        <text evidence="11">Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the U3 snoRNP particle. Binds to the C'/D and B/C motifs in U3 snoRNA. Component of the 25S U4/U6.U5 tri-snRNP particle, a subcomplex of the spliceosome. Binds to the 5' stem-loop of U4 snRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
            <location evidence="1 11">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the eukaryotic ribosomal protein eL8 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH37870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J6J1"/>
    <dbReference type="STRING" id="742152.A0A2H3J6J1"/>
    <dbReference type="OMA" id="IKNQIYA"/>
    <dbReference type="OrthoDB" id="1924699at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000002">
        <property type="entry name" value="NHP2-like protein 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002415">
        <property type="entry name" value="H/ACA_rnp_Nhp2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018492">
        <property type="entry name" value="Ribosomal_eL8/Nhp2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00881">
        <property type="entry name" value="L7ARS6FAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00883">
        <property type="entry name" value="NUCLEARHMG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="12">
        <location>
            <begin position="22"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00066222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PCH37870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="128" mass="13952" checksum="A85A6BD039722D06" modified="2018-01-31" version="1">MTDAATRAKAWPLAGPELNNQILDLVERASQFKQLKKGANEATKTLNRGIAEIIILTADTEPLEILLHLPLLCEEKNVQYVFVASKAALGRACGVSRPVIAASVTTNENKELSSQIQTIKRAIDKLMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J6L0</accession>
    <name>A0A2H3J6L0_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_167407</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
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                <person name="Barry K."/>
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                <person name="Martinez A.T."/>
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                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
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                <person name="Benoit I."/>
                <person name="Boyd A."/>
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                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
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                <person name="Kuo A."/>
                <person name="LaButti K."/>
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                <person name="Morgenstern I."/>
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                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
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                <person name="Eastwood D.C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Igarashi K."/>
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                <person name="Kallen N."/>
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                <person name="Larrondo L.F."/>
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                <person name="Nagy L.G."/>
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                <person name="Sabat G."/>
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    </feature>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="120" mass="13350" checksum="5C758B07F2071AC7" modified="2018-01-31" version="1">MSYLVPSQEEKVTSMSQWHGKLPVDHEIPPQSQQNLLDTEVASHLVPLQEEKRDFSNIGKSSLDKGLDRLKQELDSRSIRDELQSRDELARNKQIAGSVLAGAASVTGEDLGVAENKWLV</sequence>
</entry>
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    <name>A0A2H3J7B4_WOLCO</name>
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        <lineage>
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    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Glucosidase involved in the degradation of cellulosic biomass. Active on lichenan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1-&gt;3)-beta-D-glucans, releasing alpha-glucose.</text>
            <dbReference type="EC" id="3.2.1.58"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.58" evidence="14"/>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH38152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J7B4"/>
    <dbReference type="STRING" id="742152.A0A2H3J7B4"/>
    <dbReference type="OMA" id="WYWTWKT"/>
    <dbReference type="OrthoDB" id="62120at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004338">
        <property type="term" value="F:glucan exo-1,3-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000033">
        <property type="entry name" value="Glucan 1,3-beta-glucosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF34">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="127"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="18">
        <location>
            <begin position="299"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="155"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="762"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="35"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="87"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="156"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00036824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00041260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PCH38152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="785" mass="84080" checksum="1F2CD5733489565E" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J7X0</accession>
    <name>A0A2H3J7X0_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acetyl-CoA synthetase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WOLCODRAFT_166530</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467865">
        <property type="protein sequence ID" value="PCH35873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="742152.A0A2H3J7X0"/>
    <dbReference type="OMA" id="KPMTAEL"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051414">
        <property type="entry name" value="Adenylate-forming_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439:SF2">
        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439">
        <property type="entry name" value="PHENYLACETATE-COENZYME A LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23562">
        <property type="entry name" value="AMP-binding_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
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    <feature type="domain" description="Polyketide synthase-like phosphopantetheine-binding" evidence="4">
        <location>
            <begin position="605"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PCH35873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="1111" mass="123445" checksum="085D5C15C70FD6C8" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J7Z3</accession>
    <name>A0A2H3J7Z3_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_142517</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH38346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J7Z3"/>
    <dbReference type="OMA" id="SICRFET"/>
    <dbReference type="OrthoDB" id="10668144at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH38346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="280" mass="30509" checksum="C9F0224BA44A3C9D" modified="2018-01-31" version="1">MYHISSNALSLTCRETRRHSVPYTFDFDHADSGYEADAETDHTTNIRASRSSRRNRINARKTQSLPPCLRNLHTSHRVADNMAIHVELTDFTQPSRTDFASRQGLRATSSPQVPSTHTTTHTSGTSSRPGIGLGLSLPTAFSIPCHQTPVVSTASAATTAVARAHSRNNPTITMQRTDSGSSTQPYSIRPPGLSSPVPSDEDAEHWWEPVGHSHMRGRQGLPMRPLSPLAAESITIEVVLPTPPLSLASSMDSTSEADTVPPGAPRMRTIDHFPFDPLYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J8R5</accession>
    <name>A0A2H3J8R5_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Adenylate kinase</fullName>
            <ecNumber evidence="6">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP-AMP transphosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">ATP:AMP phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Adenylate kinase cytosolic and mitochondrial</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Adenylate monophosphate kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ADK1</name>
        <name evidence="10" type="ORF">WOLCODRAFT_23460</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
            <location evidence="6">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Mitochondrion intermembrane space</location>
        </subcellularLocation>
        <text evidence="6">Predominantly mitochondrial.</text>
    </comment>
    <comment type="domain">
        <text evidence="6">Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the adenylate kinase family. AK2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="6"/>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH38596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J8R5"/>
    <dbReference type="STRING" id="742152.A0A2H3J8R5"/>
    <dbReference type="OMA" id="VYHEQTA"/>
    <dbReference type="OrthoDB" id="439792at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006172">
        <property type="term" value="P:ADP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046033">
        <property type="term" value="P:AMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046034">
        <property type="term" value="P:ATP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000106">
        <property type="entry name" value="Adenylate kinase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03168">
        <property type="entry name" value="Adenylate_kinase_AK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006259">
        <property type="entry name" value="Adenyl_kin_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007862">
        <property type="entry name" value="Adenylate_kinase_lid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028587">
        <property type="entry name" value="AK2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01351">
        <property type="entry name" value="adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001380">
        <property type="entry name" value="PRK00279.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001381">
        <property type="entry name" value="PRK00279.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF011100">
        <property type="entry name" value="PRK14527.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05191">
        <property type="entry name" value="ADK_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Adenylate kinase active site lid" evidence="9">
        <location>
            <begin position="169"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="NMPbind" evidence="6">
        <location>
            <begin position="71"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="LID" evidence="6">
        <location>
            <begin position="168"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="7"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="51"/>
            <end position="56"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="98"/>
            <end position="100"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="127"/>
            <end position="130"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="178"/>
            <end position="179"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PCH38596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="258" mass="28734" checksum="B069AB932B1E1F43" modified="2018-01-31" version="1">MAGSDELEYLKSLVSQLNAKIEALEAKAKDAVTREKTLAQQLRTILMGPPGAGKGTQAPRIRDKFCVCHLATGDMLREQVAQKTKLGVEAKKIMDAGGLVSDEIMVGMIRDQLENNKACKNGFVLDGFPRTVPQAEKLDAMLTARKEKLDSVVELVIEDQLLISRITGRLIHPASGRTYHREFNPPKKPMVDDVTGEPLVQRSDDNVEALRKRLAVFHSQTGPVVEYYKQKNLWRPIDAAQSPSLVWDNLRKVFTSSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J923</accession>
    <name>A0A2H3J923_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">HOOK-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WOLCODRAFT_136418</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH38730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J923"/>
    <dbReference type="STRING" id="742152.A0A2H3J923"/>
    <dbReference type="OMA" id="DAKYRKC"/>
    <dbReference type="OrthoDB" id="49395at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030705">
        <property type="term" value="P:cytoskeleton-dependent intracellular transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22211">
        <property type="entry name" value="HkD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008636">
        <property type="entry name" value="Hook_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043936">
        <property type="entry name" value="HOOK_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18947:SF28">
        <property type="entry name" value="GIRDIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18947">
        <property type="entry name" value="HOOK PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05622">
        <property type="entry name" value="HOOK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19047">
        <property type="entry name" value="HOOK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116907">
        <property type="entry name" value="Hook domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HOOK N-terminal" evidence="7">
        <location>
            <begin position="10"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Hook C-terminal" evidence="6">
        <location>
            <begin position="192"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="431"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="822"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="182"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="500"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="578"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="431"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="822"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="838"/>
            <end position="852"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF19047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PCH38730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="852" mass="97238" checksum="BF65BAF29094C79C" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J9C3</accession>
    <name>A0A2H3J9C3_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WOLCODRAFT_127157</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB467876">
        <property type="protein sequence ID" value="PCH36403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J9C3"/>
    <dbReference type="STRING" id="742152.A0A2H3J9C3"/>
    <dbReference type="OMA" id="NDPPRNK"/>
    <dbReference type="OrthoDB" id="413079at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000286">
        <property type="entry name" value="MFS efflux transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051788">
        <property type="entry name" value="MFS_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514:SF3">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013742889" evidence="8">
        <location>
            <begin position="20"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="207"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="302"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="360"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="1"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PCH36403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="389" mass="41657" checksum="9017F89EE2D33CF5" modified="2018-01-31" version="1">MFASFLTLFLAGWNGGSTGALIPYIEKQYGINYAHVAILFVCTFLGYILAAAGAGPLARRVGFGHALSIAVVVELMGNVINSSQQRSFPLMCFGFFVVGSAFATQLGLCNAYFAILHKPLLWTGILHGIYGFGSFASPLVATAIASRGVPYHFFYLTNVGMNIPVFAFVWLAFRDLHALPQQPTDSPRGSTDGLSASTLRDTLKSRAVWTLAMFLVFYVGAEESIGGWIVSYTRTVRHGSPEGASWVASSFYLGVAVGRIVLPALNLLIGERLAVFLYLLCAIALELLAWFLPFFASTAICTAFVGLAISTFYTAAIITGGKLIPRNMHADAFALISSVGQSGSALWPLVVGVMSTKSGIWVVEPTVVALLGAQGICWALVPKVQRRAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JA59</accession>
    <name>A0A2H3JA59_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_155219</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467832">
        <property type="protein sequence ID" value="PCH34558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JA59"/>
    <dbReference type="STRING" id="742152.A0A2H3JA59"/>
    <dbReference type="OMA" id="LANHIPF"/>
    <dbReference type="OrthoDB" id="2802531at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF17">
        <property type="entry name" value="FUNGAL STAND N-TERMINAL GOODBYE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="2">
        <location>
            <begin position="43"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH34558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="204" mass="22674" checksum="5EFAD97FC4B87983" modified="2018-01-31" version="1">MSTLGRVLNMIMRGTMIKRHRTLSMLTKSHYLPGTRAELLGTLEEWAADEGEQASILILSGAAGTGKSTIAHELARRLDVKGHLGASFFFVRGDADLSCIAYVFPTIAYQLALSQPHMHSHIIDACRDPSFRTQDHDIEHQLDHGIIYPLSSVSEHPYSVVVIVDALDECTDPELERIPRMLHLLGKRLRLLAYPLACLAYDAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JAE6</accession>
    <name>A0A2H3JAE6_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_85278</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467965">
        <property type="protein sequence ID" value="PCH39176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JAE6"/>
    <dbReference type="STRING" id="742152.A0A2H3JAE6"/>
    <dbReference type="OMA" id="QHNISHA"/>
    <dbReference type="OrthoDB" id="3261594at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH39176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="700" mass="79084" checksum="14BDD1335E77D45A" modified="2018-01-31" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JAR3</accession>
    <name>A0A2H3JAR3_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Phosphatidylserine decarboxylase proenzyme 2</fullName>
            <ecNumber evidence="11">4.1.1.65</ecNumber>
        </recommendedName>
        <component>
            <recommendedName>
                <fullName evidence="11">Phosphatidylserine decarboxylase 2 beta chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="11">Phosphatidylserine decarboxylase 2 alpha chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="11" type="primary">PSD2</name>
        <name evidence="14" type="ORF">WOLCODRAFT_110643</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H(+) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CO2</text>
            <dbReference type="Rhea" id="RHEA:20828"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="EC" id="4.1.1.65"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
        <text evidence="11">Binds 1 pyruvoyl group covalently per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="11">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Golgi apparatus membrane</location>
            <topology evidence="11">Peripheral membrane protein</topology>
            <orientation evidence="11">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Endosome membrane</location>
            <topology evidence="11">Peripheral membrane protein</topology>
            <orientation evidence="11">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The C2 domains have an essential, but non-catalytic function. They may facilitate interactions with other proteins and are required for lipid transport function.</text>
    </comment>
    <comment type="PTM">
        <text evidence="11">Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type II sub-subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.65" evidence="11"/>
    <dbReference type="EMBL" id="KB467987">
        <property type="protein sequence ID" value="PCH39320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JAR3"/>
    <dbReference type="STRING" id="742152.A0A2H3JAR3"/>
    <dbReference type="OMA" id="TCASRDW"/>
    <dbReference type="OrthoDB" id="67700at2759"/>
    <dbReference type="UniPathway" id="UPA00558">
        <property type="reaction ID" value="UER00616"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004609">
        <property type="term" value="F:phosphatidylserine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
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        <location>
            <begin position="86"/>
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        <location>
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        <location>
            <begin position="546"/>
            <end position="574"/>
        </location>
    </feature>
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        <location>
            <begin position="591"/>
            <end position="628"/>
        </location>
    </feature>
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        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
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        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
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        <location>
            <begin position="151"/>
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        </location>
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            <begin position="189"/>
            <end position="204"/>
        </location>
    </feature>
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            <begin position="212"/>
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        </location>
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            <begin position="481"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="598"/>
            <end position="614"/>
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    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="11">
        <location>
            <position position="827"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="11">
        <location>
            <position position="885"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="11">
        <location>
            <position position="972"/>
        </location>
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    <feature type="active site" description="Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity" evidence="11">
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            <end position="972"/>
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        <source>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Phaeolaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="11 12">MD-104</strain>
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        <subcellularLocation>
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        <text evidence="2">Belongs to the COG4 family.</text>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JB47</accession>
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
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                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
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                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="PCH38815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JB47"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <end position="84"/>
        </location>
    </feature>
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        <location>
            <begin position="68"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH38815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="104" mass="11515" checksum="161BAFB974F5B2BB" modified="2018-01-31" version="1">MYDKLTPVGSVWNISRADEPGKARGSGMGRRYLTPEGVRGSISLHSGRSRRLNLDAASTTTPRDRVMRSRRRRPRVRRVSAHISPPTVRARAAAVGVTCDYLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JBG4</accession>
    <name>A0A2H3JBG4_WOLCO</name>
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            <fullName evidence="5">HTH TFE/IIEalpha-type domain-containing protein</fullName>
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    <gene>
        <name evidence="6" type="ORF">WOLCODRAFT_139687</name>
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    <organism evidence="6 7">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TFIIE alpha subunit family.</text>
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    </dbReference>
    <dbReference type="GO" id="GO:0005673">
        <property type="term" value="C:transcription factor TFIIE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
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        <property type="entry name" value="TFIIE_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021600">
        <property type="entry name" value="TFIIE_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024550">
        <property type="entry name" value="TFIIEa/SarR/Rpc3_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13097:SF7">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13097">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIE, ALPHA SUBUNIT"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
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            <begin position="14"/>
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        </location>
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        </location>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="411"/>
            <end position="425"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00008947"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JBU0</accession>
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            <fullName evidence="1">Uncharacterized protein</fullName>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="PCH37283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JBU0"/>
    <dbReference type="STRING" id="742152.A0A2H3JBU0"/>
    <dbReference type="OMA" id="VIEIMDI"/>
    <dbReference type="OrthoDB" id="2669721at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH37283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="324" mass="36386" checksum="B5961AD9705B916F" modified="2018-01-31" version="1" fragment="single">TRKVLSSLLTNDSIIPEYTNFVYGKDYLNACNKGDIRDDDIVLMFSMDGVQLYVCKQSDCWVYMWVLLDYTPEVQYKKTHIILGSIIPGPNFCVTNKPRNVDSFIFPGLRILSSHMIEGLKIWDPRHGIIDSKLFLLLATADSVGMTYLNGLVGHSGAQGCRIYCPLKGHHKPGSGYYYPACLKLDNYNVANCSHEDIKPQILNSVKPSKQHYDNLTCILGARTDREFQKLCLETGIAKPSLLKGLPLRSTLGLLACFPADIMHLIAINIPDLFISLWCGMIQCDPNDDRSTWGFMVLTKDTWEVHGKVSQESTLSQNARRGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JC15</accession>
    <name>A0A2H3JC15_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Erythromycin esterase</fullName>
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    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_63397</name>
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    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
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        <lineage>
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            <taxon>Phaeolaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH33497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JC15"/>
    <dbReference type="STRING" id="742152.A0A2H3JC15"/>
    <dbReference type="OMA" id="RYGCLTP"/>
    <dbReference type="OrthoDB" id="413649at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14728">
        <property type="entry name" value="Ere-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1660.10">
        <property type="entry name" value="EreA-like (biosynthetic domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1870.10">
        <property type="entry name" value="EreA-like, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007815">
        <property type="entry name" value="Emycin_Estase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052036">
        <property type="entry name" value="Hydrolase/PRTase-associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014622">
        <property type="entry name" value="UCP036794_erythomycin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31299">
        <property type="entry name" value="ESTERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31299:SF0">
        <property type="entry name" value="ESTERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05139">
        <property type="entry name" value="Erythro_esteras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036794">
        <property type="entry name" value="UCP_erythr_ester"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159501">
        <property type="entry name" value="EreA/ChaN-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH33497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="473" mass="54073" checksum="715D324EF8FC68DC" modified="2018-01-31" version="1">MLAPTTLLKQRALLESHTHPLSWQASSYDPLMSAISFNAQVVCIGDSSHGTYEFYAHRANLTKRLIEEKGSTAIAIEADWPDAFRINRYVHGAPHISSARAALSDFELFPVWMWKNEVMPPFVEYLRAHNPRVDDPAQRVSFYGMDLYSPHRSADEVIRYLERVDPEGINEALDKYNCFERFGEDTTRYAYETQFRLARDCHKEVIANLKALLANHRRYIEELGAGAHAHPAEEQFVVEMNALVVRDAEEYYRTMLTNDTKSWNLRDDHFARTLVKTAEHLGAGGAQAKIVVWAHSSHIGDARATDMGRRRGEVNVGQRCREIFGEHNVFNIGFLTNRGTVIASYDWDDPPYLQTMNAPIRSSIGSVFNEWGKGDCFVITHRVEDTPEGRRRKREVAPELSDLLDRPWHQRFIGVIYRRDTEVPSHYSRCSVAAQYDAHIRESRGIRPLEPESTDTWKGLTGGEADLTFPFGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JCC3</accession>
    <name>A0A2H3JCC3_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_97901</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468053">
        <property type="protein sequence ID" value="PCH39846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JCC3"/>
    <dbReference type="STRING" id="742152.A0A2H3JCC3"/>
    <dbReference type="OMA" id="CFWIVVM"/>
    <dbReference type="OrthoDB" id="10249433at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277">
        <property type="entry name" value="ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277:SF64">
        <property type="entry name" value="SUPERFAMILY HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01760)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine aminopeptidase S33" evidence="1">
        <location>
            <begin position="140"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH39846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="330" mass="37452" checksum="15F97857AB07F25D" modified="2018-01-31" version="1">MVGLPLALWIYKCLMMVIFQRKIIYMGYAPPGARTEELHASLLPREIRCMEVCLESEKHVRLHGIIIHQDALDCSARDPDVVIVYLQGNAGNPLARIPVFEKLLSGLSQSQQSPKNSTLSVHIIAVAPRSYWKSSSRTPTERSLIADYHRVLSYAVERYPKSTIVLYGHSLGGAIAVCLASHLSSTDYPTVQGLVLENPFASIPDMVQALYPQRWLPYRYLGHLAFDKWNAVAAMQSAKGGTDSLLSRLSRDMLVLLSEKDEIVPPTMGEEIYRARESTRHQGTNYRSAERGQRRLVMVRGALHEQAWMHRQWVNEMTAYVHQVRARKDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JCG1</accession>
    <name>A0A2H3JCG1_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_166222</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467843">
        <property type="protein sequence ID" value="PCH35358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JCG1"/>
    <dbReference type="OMA" id="AFDQLEC"/>
    <dbReference type="OrthoDB" id="2998779at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH35358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="303" mass="34048" checksum="C4FF38D6B5FB19EA" modified="2018-01-31" version="1">MQTHFFGHIAVFLEASLGNIETCAKLCLVCKTSQEWMTPLLYETVALTSSSTIRAFARTLKSTSHPPRKCDRPTHGGLGDRVCYLWIGPTTSTAEHDLPYASTHWSIDDLQAILMHCSCLRSLAIVNLAQHLNFRINSCIPSTVENIYLGPVHGSLDLPRLPCLQNLRSITSLDTFFSMDEMQTIVASPYLQRVRRFYGTPAHIDWAFRQLSCLRRAGTLEELQVVCCDNSIDDATEVLKHYKEAYVAHADERVLLVARAHPVYWQIDGIGSLHQDWLSVVNSSVVETMPQASFKMISPQLNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JCL4</accession>
    <name>A0A2H3JCL4_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF1680-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WOLCODRAFT_110071</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467931">
        <property type="protein sequence ID" value="PCH37543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="PCH40302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OMA" id="HPFANVQ"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH40302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="398" mass="43996" checksum="DB369F6DE52FAC9B" modified="2018-01-31" version="1">MSAASIRHPFASVQYYASTLTVNDYTELQKPPPVPKRRSIIPPALRARSPFSLSKKASSPARFVKKGHQMTLILDGQGTTMPVYRCNDTISGSVLPANASGLTSLQVKIHGSLKIKEVAGAGGADTEILRVSVFSWNDQQNISLPSRIPLHYTLPDDYRDNANGERYPLPPTYDAHLNGIPGFNVYVMYYVLVEFVRAERKKSPFWQKKFCIRAPFLLQQHTRPVYSGPFRLNFTKTPTSPQTLFVFAIESRQSCRTHIEAHVFLPLSREHLTQRSIAPLRIHLSRTTGVCASRLGVTHAQDKGQLFSSRSIGRGVIHNTSRGINSLAWSGTITIAPSVFSGSFKVHGLQVSDSIVITIKPPDSARSHFMSLCETIPVRLTSEAHECSSAMAIAEAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JE35</accession>
    <name>A0A2H3JE35_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WOLCODRAFT_150510</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="PCH40466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS_dom"/>
    </dbReference>
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        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42910:SF1">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR42910">
        <property type="entry name" value="TRANSPORTER SCO4007-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="125"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="182"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="244"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="348"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="388"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="416"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="56"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="477"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="490"/>
            <end position="504"/>
        </location>
    </feature>
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        <location>
            <begin position="505"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH40466.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="514" mass="55952" checksum="6CFCE282378FFEF5" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JEB1</accession>
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            <fullName evidence="5">CCHC-type domain-containing protein</fullName>
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    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1221748"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6 7">MD-104</strain>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503:SF22">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <accession>A0A2H3JED1</accession>
    <name>A0A2H3JED1_WOLCO</name>
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        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
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        <name evidence="9" type="ORF">WOLCODRAFT_139712</name>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
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                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
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                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
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                <person name="Stenlid J."/>
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                <person name="Sun S."/>
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</entry>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
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                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
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                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
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                <person name="Benoit I."/>
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                <person name="Coutinho P.M."/>
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                <person name="Ferreira P."/>
                <person name="Findley K."/>
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                <person name="Kallen N."/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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            <dbReference type="EMBL" id="PCH34347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="296" mass="33399" checksum="300C8C428C4E4CC0" modified="2018-01-31" version="1">MPLAAATLARQLEELHLLKCSLMPDETLQFTSVSEDSDRWSQLLESYADNPDADAVNEQCEEPVRFTVKVNGLDIWVAAELSHAYNGEHIGDNYVSVTFKGSRLGRAEQAQWQAIIDEKTREIHDSEYPVYELISAHLLPFLHAEAEKVAHNEYPSETVREASSSTTSPTPLYHVLLTSHHLKSPNKRRSLQQWVHELPVTGFAKVGYPGVIYCSGEQPQVEEFAANVKAMQWLALKVRFVEPLPDAEHQAETNNRRRWTEFEKVGEVVEEMRRLGKERYVVEMGIGSAGGSTLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7 8">MD-104</strain>
        </source>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
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        <text evidence="2">Belongs to the RNase PH family.</text>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:nuclear mRNA surveillance"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:rRNA catabolic process"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
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    </dbReference>
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        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050080">
        <property type="entry name" value="RNase_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953:SF1">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0271">Exosome</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="6">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PCH35154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="170" mass="17612" checksum="29C5F52542A3E5B4" modified="2018-01-31" version="1" fragment="single">RPLTIVYEGLDRVDGSARFGFGETKALTSVSGPIEVRAALEQPSQATLDVHVRPLASLPGTDAKALAATLKALLTPALFLAHHPRSLVQLVAQAICSNGARAGSWRSTLIAALINASCAALLNAASVPMRGVVCAVAVGRRGDTLLLDPAEEEFSDLLGSGCFAFLFSSS</sequence>
</entry>
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    <name>A0A2H3JER5_WOLCO</name>
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    <gene>
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    <organism evidence="2 3">
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        <lineage>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467920">
        <property type="protein sequence ID" value="PCH37229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JER5"/>
    <dbReference type="STRING" id="742152.A0A2H3JER5"/>
    <dbReference type="OMA" id="PHQLRHP"/>
    <dbReference type="OrthoDB" id="659at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1580.10">
        <property type="entry name" value="paralog of FGE (formylglycine-generating enzyme)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
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        <property type="entry name" value="EgtD_Methyltrsf_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005532">
        <property type="entry name" value="SUMF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042095">
        <property type="entry name" value="SUMF_sf"/>
    </dbReference>
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        <property type="entry name" value="ERGOTHIONEINE BIOSYNTHESIS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43397:SF2">
        <property type="entry name" value="HISTIDINE-SPECIFIC METHYLTRANSFERASE SAM-DEPENDENT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="C-type lectin-like"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="210"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH37229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="453" mass="51585" checksum="07225386D80AA129" modified="2018-01-31" version="1">MPAIDQWRAMWAAWDFSTQHMIPPSMLFQKPIDLWRICLFYIGHIPMFLLIHLSRMLKEPDTEPVEFKTDMTYHHCSERSIQTDDPTQCHSHSEVPMLEVDWPSLPSITAHQYRVRERMLKLYRDIDAGAVILTGRIVRMLFMTLEHEAFHVEIWGAIPPSGFSPPHWPVLAWDNAAEPKVETITLGPDTVALGHDDNEADDGSPDVAAHDFGWDNEHPRRRVYVPQFKIAMRPVTNGKFYDFFAEEGMGVVEFAPFAHRLPLKVARDRPIVTSYDNLSTYASVKGGHIPTKPELHLFFDMFQCGYEGGTNIGFRNRHSVPATMGGEKGGGKGHNGGVWEWTSIVLEQHDGFSASKLYPGNPVGFFDGHHQVVVGGSYATTPRLAERRTLRNFYQHNYPYLRLEQAQTWRTHMGYVALHRLMNLNIVGYSLLVVVGILMDIEDANANFVTMTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JF06</accession>
    <name>A0A2H3JF06_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WOLCODRAFT_139451</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467832">
        <property type="protein sequence ID" value="PCH34577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JF06"/>
    <dbReference type="STRING" id="742152.A0A2H3JF06"/>
    <dbReference type="OMA" id="KLWSAYH"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19071">
        <property type="entry name" value="AKR_AKR1-5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000015">
        <property type="entry name" value="Oxidoreductase, aldo/keto reductase family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF13">
        <property type="entry name" value="ALDO_KETO REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="6">
        <location>
            <begin position="29"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="5">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PCH34577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="275" mass="30714" checksum="62E251655F30F804" modified="2018-01-31" version="1">MSLSLRSTVRLSSGYDMPLLGLGVYQNNDCIPACIAALKHGYRHIDSARMYQNEARVGRAVRESGVPREDVFVTTKIYHPEFGYESTLKAVDNSLQKFKFDYVDLFLIHSPISGKEMRLATYRALLEARNAGKIKTVGVSNYGVKHLEEIREAGLETPAINQIELHPFCQQKPIVAYCKERGIVIQAYCPLVRGSFDNPVLQEVAQKYKKDVAQVLVRWSLQSGFSPLPKSSQPARVVSNADLYDFEISSEDVAKIDALDRGKDGAVSWNPVDAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JFD9</accession>
    <name>A0A2H3JFD9_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Deoxyuridine 5'-triphosphate nucleotidohydrolase</fullName>
            <shortName evidence="6">dUTPase</shortName>
            <ecNumber evidence="6">3.6.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">dUTP pyrophosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WOLCODRAFT_49836</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in nucleotide metabolism via production of dUMP, the immediate precursor of thymidine nucleotides, and decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>dUTP + H2O = dUMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10248"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61555"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="3.6.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 6">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the dUTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.23" evidence="6"/>
    <dbReference type="EMBL" id="KB468053">
        <property type="protein sequence ID" value="PCH40611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JFD9"/>
    <dbReference type="STRING" id="742152.A0A2H3JFD9"/>
    <dbReference type="OMA" id="ISPSKWA"/>
    <dbReference type="OrthoDB" id="419889at2759"/>
    <dbReference type="UniPathway" id="UPA00610">
        <property type="reaction ID" value="UER00666"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004170">
        <property type="term" value="F:dUTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006226">
        <property type="term" value="P:dUMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046081">
        <property type="term" value="P:dUTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07557">
        <property type="entry name" value="trimeric_dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008181">
        <property type="entry name" value="dUTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029054">
        <property type="entry name" value="dUTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033704">
        <property type="entry name" value="dUTPase_trimeric"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11241">
        <property type="entry name" value="DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11241:SF0">
        <property type="entry name" value="DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00692">
        <property type="entry name" value="dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51283">
        <property type="entry name" value="dUTPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="dUTPase-like" evidence="7">
        <location>
            <begin position="3"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PCH40611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="109" mass="11906" checksum="663CD4A4FABDAA3E" modified="2018-01-31" version="1" fragment="single">PNGKMPQRGTSDSVGYDLFSATNDIIPAKGQTEFNIKLKIQVPFGTYGRIAPRSGLAKKGIDVMAGVIDHDYQGEIIIILRNHIDISYSVQIGDKIAQLICEVAKNPHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JFF3</accession>
    <name>A0A2H3JFF3_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NAD-aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WOLCODRAFT_155389</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467832">
        <property type="protein sequence ID" value="PCH34727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JFF3"/>
    <dbReference type="STRING" id="742152.A0A2H3JFF3"/>
    <dbReference type="OMA" id="FPEGCFQ"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07102">
        <property type="entry name" value="ALDH_EDX86601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000009">
        <property type="entry name" value="Aldehyde dehydrogenase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
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        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="5"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PCH34727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="472" mass="50362" checksum="9F0EE2B83118D52A" modified="2018-01-31" version="1">MSQTTIIPHSQQPLVTRTYPSAPELDALVARASAAQKAWRAVPLEERIAIGRRFMDEFRAMGDEIPAELSAQMGRPVSQCAGEVRGTLDRAAYMLDIAEGALADVSLADTDKPGFRRFIRRDPLGVVLVIAPWNYPYLTTVNSVLPALVAGNAVLLKPSPQTPLTAERFALAFARAGLPAGLLAVVHLSPELAAHAARSPGIAFVSFTGSVAGGRAVAEAAVRAEGFKGVGLELGGKDPAYVRADADLEYTAAELVDGAMFNAGQSCCAIERIYVHESLYDAFVARYVELVKQYKLGDPTQPGTNLGPVVSLASAERIRKQVADAVKAGARALVPEGLFAAAQPGTTYVAPQVLVDVDHTMDVMTEETFGPVIGIMKVSRDEEAVALMNDSRYGLTASVWTNAQANPASEAAFLEIVDKLETGTVFLNRCDYLDPALAWTGVKDSGRGVSLSKFGYDQLTRAKSVHMKIKTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JGK4</accession>
    <name>A0A2H3JGK4_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_80993</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF1">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH35844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="343" mass="39624" checksum="7136B401786D261E" modified="2018-01-31" version="1">MKPSLDQLNHFLRPLVDELALFWEPGVFFSRTADFVNGRLVHCALIPLVCDLPAAWQVSGHGGHSATHLCSFCWQKLEDIENLDSQQWRKHSPQEHQRLAEQWKSKTSVKAHQETFDKNGVRWSELLCLPYWDPILFTVIDTMHNQYLGLLKTHCRDVWGMKKDMNDRDGIYNSKHKIHVNLARTELPSWINPAPANLGTSERGKLHANQWLTACTINFPITLIRLWGVESATSRKHGMLHNFMELVATVTVSSLLETSDDLIVLYNASITRYLKSLKGLYKEVDFKPNHHLALHVGDFLREFGPVHSVRTFFLEQLNYTLQREHTNLKFGKYVAQQSLKFES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JGU0</accession>
    <name>A0A2H3JGU0_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_110511</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467954">
        <property type="protein sequence ID" value="PCH39063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JGU0"/>
    <dbReference type="STRING" id="742152.A0A2H3JGU0"/>
    <dbReference type="OMA" id="VRENISW"/>
    <dbReference type="OrthoDB" id="1937642at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH39063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="387" mass="42624" checksum="18E4B9606F9169BA" modified="2018-01-31" version="1">MEHPALFILNDAIANITQIMEKHTTEPHWQDPHCILIVLTVIGGDIIRSALASLTSHSTFTPVAFSFGWVAYSFSALLSKVGDGHLMPAPDCGAILVNAHSGYSRAISSWPLARIVRDHQPPDNRQDGLTITFYRTRTDKATGVPDRDGVYYFGVLVIVMQFAIASMPGVLYGSWSVFVVTLFGTILVQMNSALGQWYDEKWSGGSVQKGSEVVCITRGNGDSNVQVVITGEGGMKLEHIATGRIVSRRATTPITFLLATLWLLHLVTVERFHAYTWFSIIIGALGMLQNAVAATVKRSPGALGFHLKQEGVVHEKKVFAALQAAEEVEHKVGLSLMPIFFPGELRETEKRWMESKSLEYTRDKQALAVQTASSSADDPNVYRLRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JHB9</accession>
    <name>A0A2H3JHB9_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_137477</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH41572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JHB9"/>
    <dbReference type="STRING" id="742152.A0A2H3JHB9"/>
    <dbReference type="OMA" id="SNHIGQE"/>
    <dbReference type="OrthoDB" id="3262664at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="113"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH41572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="235" mass="25600" checksum="18D87B864AAA5E1C" modified="2018-01-31" version="1">MSLSVDDLVSAFNSNHIGQEAIDLANLHAQLAQVLRAQPCSSSQSIPGRRYPRSNTPLARTPSSSFSWESSEFTRGRSSSSASATHRWGAEERAWDPEDNEDDERMVEDMLLSPPASSRQNAASSAAMSSGSEMLSRQSSMQHISSSFGYAQNELPSPNSSMFATTDPFYTAQLQASQNPTSPLFAQAGRLPPHSPFGLAQQFQSAYNHINAHHPVPAEIDPHHMFGAQQATFMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JHW2</accession>
    <name>A0A2H3JHW2_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_167427</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467920">
        <property type="protein sequence ID" value="PCH37318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JHW2"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH37318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="159" mass="17697" checksum="29BCBA3DE43BED44" modified="2018-01-31" version="1">MLAGYLYVANARRRQPQAAGARSVREKVPQHNDLSTIRLQSLIHQLDVAAWQPKVGLYNLNDGPMISSPRVPCLSRRSPATEREGETTLHARSEYMLPEMIKTELRSRPARRSGQRSCEPTCPEVCRSQHKGVTGCAAMRTEAATVPPEVDPHARCLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JI01</accession>
    <name>A0A2H3JI01_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_159535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467922">
        <property type="protein sequence ID" value="PCH37368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JI01"/>
    <dbReference type="OrthoDB" id="3231544at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH37368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="464" mass="51824" checksum="E3790489FB260AC2" modified="2018-01-31" version="1">MATELGVRTLVLTAYPKDNQAYVELHDFNDAFDSAPSFKNRAEWENDLWGQWKAYSHDVILDKKTSQGSDEEDDSGDSDDDRKFSLPVDDEGLPILPLYNPRKRLRPARMRQIIRLFLNRHYQLACGASDRACPWGLMASEPESFFDNAMMPDGIALAEPHHMRKEDCIAILQHWEDAKSSRNGAVLFRFKKYTTAYRNNLKHELCNAIYRNLSSSVPPAKKPQMKEYVEIDAAGPGSSTAAGGPPGSGAQAVAKLVAAAVAEVAEVAEVAEVAEVVEVAEVAGKIMVAKTSPTKMSMPQTQFEPLTSSGKGKGRARTTITDWVDNWGATDRSNNPENIRHLPPVWALVSPTCRQNYLLALGTGQSYKTMVVKCSELIGSQVLFSQDEDGPHWASWTWEHHRRADIHGPSGLDEVAYWLRHDQPMKDDECKLTSDKALIQRIVLMIGILYREMEDAQFPDDDGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JI11</accession>
    <name>A0A2H3JI11_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF676 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_69898</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the putative lipase ROG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH41511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JI11"/>
    <dbReference type="STRING" id="742152.A0A2H3JI11"/>
    <dbReference type="OMA" id="TAETWAH"/>
    <dbReference type="OrthoDB" id="442243at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007751">
        <property type="entry name" value="DUF676_lipase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47842:SF1">
        <property type="entry name" value="DUF676 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47842">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05057">
        <property type="entry name" value="DUF676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF676" evidence="2">
        <location>
            <begin position="26"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH41511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="369" mass="39909" checksum="AD2DCAEB262B7AE1" modified="2018-01-31" version="1">MAQSSEHDTPGGPHAESRSPPADLILVIFIHGFKGTDTTFGGFPERIQYILSESIDNVLVESIVFPAYETKGELSEAVIRFADWLTSLTVEREVARGLGGGAGKAKIILCGHSMGGLLAADALIEFVRTRPDQGAPLWPNIIGCLAFDTPYLGLHPHVFRNSATQATSYAQNVLSSFQSFTKQTSAASNSSRASIAAPASASRSTAASASAWQKWAPAAYAVGGALIAGAAAGAAYYRREELSVSYKWASDHMKYVGTLWDEGKLHKRLEELLAIEEQMGVIFRTFYTFLPPAPPSHPSPRTFIVLPKTPQLAQHFIQAPNELATDEVHAHTGMFDIKTNDGYYEIGLTTAQLIREVVSTSRTQPVEQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JIA4</accession>
    <name>A0A2H3JIA4_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_25032</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
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                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
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        <property type="project" value="TreeGrafter"/>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
    <sequence length="353" mass="38397" checksum="DCD1118AF00C1FCA" modified="2018-01-31" version="1">MSGLLPSIESFAKGAFATTAGLGTVCFSLLFFGQNFLIYLPAYPPGSRTAVASPGDHGLPYQDVELRTSDNIKLRCYMFVQRKDISQLGALDVESSEDETEEQFSSRRPTVMMFHGNGGNIGHRIALAKIFYVKMRCNVFMLSYRGYGLSEGSPSEKGIQLDAQCALDYIQNHPSLAGSPIVLYGQSIGGAVSIDLTSRNPHAVRALILENTFLSLPRLVPNAFPILGPVSFLCHQKWDSASKISLIPPTTPILMLSGLQDEVVPPEHMRSLWELVQARTGGPSRSESSGGKTVHQVPSASRYAQFVEFEHGAHNDTCVQPDYWTTIDKFIKSLDGSRSASPVSPTSSSSESS</sequence>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
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            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
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                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
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                <person name="St John F."/>
                <person name="Stenlid J."/>
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                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
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            <begin position="80"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH39733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="109" mass="12623" checksum="9C10524997B2D6D8" modified="2018-01-31" version="1" fragment="single">AECRWGDPCGQLLTDLTAAGIARHLRQYHFDDTTTWRESRSLPHRGPCRWSVGNLPCEQEMLYTGFGKHIATVHVQSTVRRCPQCGSRFSRSDAFARHRRDYCPMRTRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JJA8</accession>
    <name>A0A2H3JJA8_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="3" type="ORF">WOLCODRAFT_151966</name>
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        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
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                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
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                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
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                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
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                <person name="Larrondo L.F."/>
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                <person name="Nagy L.G."/>
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                <person name="Patyshakuliyeva A."/>
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                <person name="Sabat G."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JJA8"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="247"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="202"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
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        </location>
    </feature>
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        <location>
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        </location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="272"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH41931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="283" mass="30788" checksum="439777A1C135D3F9" modified="2018-01-31" version="1">MDLPAKRPPSALRLQSARLVEAPQMSSQSIRAEKTRRKRPNTPPSDGPSQRQPEKRQREDCGDNSSGRETSGINVAGIRGASAFKNLYSTSKPPDGGVSRASTPSEQQRAPANAPASRATSIAPLHAPNSSTAFGQAMGSASSGLNKNTSDLIAKIKAETQKMQCKLTSNTNNVHDLGKKMKEVVGYIDEVDKWSKSVEKAINEADDTIAALTNHVARLEDQYMELEDFMHSTRDWMVNRPKITAAAEAEEGSMGEEPALPQPATRKKMRNNKFQVSCESLPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JJW1</accession>
    <name>A0A2H3JJW1_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
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    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_148995</name>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
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    <accession>A0A2H3JKH6</accession>
    <name>A0A2H3JKH6_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Checkpoint protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WOLCODRAFT_89962</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the HUS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468124">
        <property type="protein sequence ID" value="PCH42690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JKH6"/>
    <dbReference type="STRING" id="742152.A0A2H3JKH6"/>
    <dbReference type="OMA" id="VCWMRLE"/>
    <dbReference type="OrthoDB" id="337750at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030896">
        <property type="term" value="C:checkpoint clamp complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044778">
        <property type="term" value="P:meiotic DNA integrity checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.70.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046938">
        <property type="entry name" value="DNA_clamp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016580">
        <property type="entry name" value="HUS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007150">
        <property type="entry name" value="HUS1/Mec3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12900:SF0">
        <property type="entry name" value="CHECKPOINT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12900">
        <property type="entry name" value="MITOTIC AND DNA DAMAGE CHECKPOINT PROTEIN HUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04005">
        <property type="entry name" value="Hus1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011312">
        <property type="entry name" value="Cell_cycle_HUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55979">
        <property type="entry name" value="DNA clamp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR011312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PCH42690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="297" mass="32708" checksum="86603718B72B223D" modified="2018-01-31" version="1">MRFRTNVGNIDTFYKILQTVEKLQKRCSIKLTETEMHIICNSDVNEGGIQMWSQIRVPSMFIDYRIQSNANNVILLTVSSEALVAAMRSAATPSSSGPGTLTKKGEKPTINFDISISTRGGRRVRIAHDVPIDITRTQEIEKLKEPLCPEPEVHILLPPLARLRTVVERMKPLAGKIIKLSGNMSGCLTLSAETEQSRVDVSWTGLSNPDMNEDGPSQALRRANGEELPARGPKQMYGVLVSLGSLQKFLNCHVVSTTTIACICQNHCLVLYVYVGEVANRGGVLTFYIPAIIDEGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JL61</accession>
    <name>A0A2H3JL61_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amidohydrolase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_64922</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH38468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JL61"/>
    <dbReference type="STRING" id="742152.A0A2H3JL61"/>
    <dbReference type="OMA" id="YNQPRRD"/>
    <dbReference type="OrthoDB" id="194468at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.520">
        <property type="entry name" value="Amidohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.90">
        <property type="entry name" value="Amidohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10910">
        <property type="entry name" value="Amidohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051781">
        <property type="entry name" value="Metallo-dep_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43135">
        <property type="entry name" value="ALPHA-D-RIBOSE 1-METHYLPHOSPHONATE 5-TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43135:SF3">
        <property type="entry name" value="ALPHA-D-RIBOSE 1-METHYLPHOSPHONATE 5-TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="1">
        <location>
            <begin position="1165"/>
            <end position="1207"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH38468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="1258" mass="138605" checksum="964C08A195BF9915" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JLE9</accession>
    <name>A0A2H3JLE9_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_149486</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="PCH38548.1"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH38548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="67" mass="7581" checksum="9A61456E82D17DCD" modified="2018-01-31" version="1">MTIPVRLHLQDLLGISTDEGADEDIDDKNEEGDEGDEEDEEDEEDEEDGDEEDEDEDEEDIEIILAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JLR3</accession>
    <name>A0A2H3JLR3_WOLCO</name>
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        <submittedName>
            <fullName evidence="3">Carbohydrate esterase family 16 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_25747</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468135">
        <property type="protein sequence ID" value="PCH43140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JLR3"/>
    <dbReference type="STRING" id="742152.A0A2H3JLR3"/>
    <dbReference type="OMA" id="KWTTWIS"/>
    <dbReference type="OrthoDB" id="1600564at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
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        <property type="entry name" value="GDSL_Est/Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45648">
        <property type="entry name" value="GDSL LIPASE/ACYLHYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_4G14700)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45648:SF22">
        <property type="entry name" value="GDSL LIPASE_ACYLHYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_4G14700)"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013850488" evidence="2">
        <location>
            <begin position="25"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH43140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="322" mass="35614" checksum="14F8F7D7ED130562" modified="2018-01-31" version="1">MAMFDLLRLTTLALLLAFTRLSVAQGPYPGQIKNLVTFGDSYTDVHQTGDNGTAWPVYAAMYGNFTLYPFARSGATCSNNLTYRPYPSVFESQLPLYFTEEQNGSLELDSTTTMYTLWIGTNDVGANALLTGSQTPGVTLVNTTSCAVEWVKVLYASGARNFIFQNMLPLQDTVLYSANSYPNGYWSEQRNTTEWNVFMTEITNTGNALSRMMLEALAPTLKGAHLGIFDSYGLISNVRSDPQDYLNGTVPYNVTGCIRSCILQINESTSGPGDCTISEGTARDSFLWYDELHPSEQTDRVIAREIAGAIVRNSSDWITWLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JMG3</accession>
    <name>A0A2H3JMG3_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_23770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468053">
        <property type="protein sequence ID" value="PCH39999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JMG3"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH39999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="72" mass="8159" checksum="5C9F72D9BC33E50E" modified="2018-01-31" version="1">MSKAHERDSGVRLLATSPSDFSHFTRSSQRNGHPVSMSQNDNDRHNRVISLSRYKPQNACVSVNICRACRDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JMH9</accession>
    <name>A0A2H3JMH9_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_167714</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Transcriptional coactivator that stimulates GCN4-dependent transcriptional activity by bridging the DNA-binding region of GCN4 and TBP (SPT15), thereby recruiting TBP to GCN4-bound promoters. Involved in induction of the ribosome quality control (RQC) pathway; a pathway that degrades nascent peptide chains during problematic translation. Required to prevent stalled ribosomes from frameshifting.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MBF1 family.</text>
    </comment>
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        <property type="protein sequence ID" value="PCH38938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JMH9"/>
    <dbReference type="OMA" id="NPQCSAL"/>
    <dbReference type="OrthoDB" id="3226546at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13560">
        <property type="entry name" value="HTH_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00035107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH38938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="72" mass="7392" checksum="6A2390F26F6A5EE1" modified="2018-01-31" version="1">MAPNPQCSALAAAKDKKGLSYSQIASQIGISEQRVVDICTGAAVATTGEFNSLATVLDIKTPPPHDSAHAQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JN25</accession>
    <name>A0A2H3JN25_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_136727</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468053">
        <property type="protein sequence ID" value="PCH40209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JN25"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH40209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="99" mass="11126" checksum="21693C8B6DC9F495" modified="2018-01-31" version="1">MMSVTVTHHTSVWILDFNSSATSRSLMQQLLHTQRCGAVDPKNLLSDVQPERALLVFREEPISKRPAPHEPPISLKGYPRTPILLPSYIRCHAAARCPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JN67</accession>
    <name>A0A2H3JN67_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="4">PPIase</shortName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WOLCODRAFT_26065</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="KB468146">
        <property type="protein sequence ID" value="PCH43622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JN67"/>
    <dbReference type="STRING" id="742152.A0A2H3JN67"/>
    <dbReference type="OMA" id="ENHEITH"/>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01926">
        <property type="entry name" value="cyclophilin_ABH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000001">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0697">Rotamase</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013422373" description="Peptidyl-prolyl cis-trans isomerase" evidence="4">
        <location>
            <begin position="27"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="5">
        <location>
            <begin position="37"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PCH43622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="222" mass="24339" checksum="8F09604E373BC3D0" modified="2018-01-31" version="1">MKFRRLTLGLILVTIAAFFCAQSVEAAKGPKITHKVYFDIKHGDENLGRVVLGLYGGTVPKTVENFRALATGVKKDGTELEPGFGYKGSKFHRVIKNFMIQGGDFTKGDGTGGKSIYGDKFADENFKLRHTRPGLLSMANAGKDTNGSQFFITTVVTSWLDGKHVVFGEVLEGMDIVHVIEDVPKGRNDRPTEDVVIVDCGELPLDVQTYSDSKEVPLRAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JNY4</accession>
    <name>A0A2H3JNY4_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_25784</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468135">
        <property type="protein sequence ID" value="PCH43205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JNY4"/>
    <dbReference type="OMA" id="HESFIVV"/>
    <dbReference type="OrthoDB" id="2590746at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="510"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
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                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
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                <person name="Kallen N."/>
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                <person name="Sun S."/>
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            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
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            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="333" mass="37677" checksum="65473C7025BEF33C" modified="2018-01-31" version="1">MLPLPASYTSRRQFSRGGAGSHRSTRDVLLTRARITNLGLLLLSTFAIFSFLVNLNHYYTSPRAYPHADGEPFGIVETIQRDETLSTLDHLIIVPGHAIWIGIDPAKRLDDNEWILEPYQRGGGRVAAFYKHIATAAELSQQDDHALVVFSGGQTRRTSTTTEGESYMRLALTTGALNASAAPLRATTEDFALDSYQNLLFSIARFHEYTGRYPVQITVIGYGFKSQRFNELHRAALRWPRARFHYVGIDAEGEEHKKALEGERLNGYIPYTLDTYGCHDLLRSKRRTRNPFIRYHSYYTSSSELAALFDWCPGDRTGGQTTTFDGPLPWDYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JUC9</accession>
    <name>A0A2H3JUC9_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Lanosterol 14-alpha-demethylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WOLCODRAFT_25406</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD-104</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
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    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the cytochrome P450 family.</text>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
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        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304:SF2">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10 11" id="KW-0349">Heme</keyword>
    <keyword evidence="7 10 11" id="KW-0408">Iron</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="10">
        <location>
            <position position="493"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PCH42499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="548" mass="61976" checksum="6AB75F71A65F072E" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JV99</accession>
    <name>A0A2H3JV99_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_136647</name>
    </gene>
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        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="742152.A0A2H3JV99"/>
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    <proteinExistence type="predicted"/>
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            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="524"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="580"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="660"/>
            <end position="760"/>
        </location>
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        <location>
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            <end position="80"/>
        </location>
    </feature>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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        </location>
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        </location>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
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            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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        </location>
    </feature>
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        </location>
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        </location>
    </feature>
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        <location>
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            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="724"/>
            <end position="733"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH40087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JVA5</accession>
    <name>A0A2H3JVA5_WOLCO</name>
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        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein uL29m</fullName>
        </recommendedName>
        <alternativeName>
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        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WOLCODRAFT_136653</name>
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        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9 10">MD-104</strain>
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        <subcellularLocation>
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        </subcellularLocation>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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</entry>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
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        <location>
            <begin position="48"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="PWI" evidence="4">
        <location>
            <begin position="523"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="220"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="471"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="220"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="305"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PCH40407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="623" mass="70622" checksum="D9D4B6BF1F59FE2F" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JWB8</accession>
    <name>A0A2H3JWB8_WOLCO</name>
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        <recommendedName>
            <fullName evidence="5">Peptide-methionine (R)-S-oxide reductase</fullName>
            <ecNumber evidence="5">1.8.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WOLCODRAFT_123292</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-methionyl-[protein] + [thioredoxin]-disulfide + H2O = L-methionyl-(R)-S-oxide-[protein] + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:24164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12314"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:45764"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the MsrB Met sulfoxide reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.12" evidence="5"/>
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        <property type="protein sequence ID" value="PCH44283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OMA" id="DEQWRAE"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.20">
        <property type="entry name" value="Peptide methionine sulfoxide reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Met_Sox_Rdtase_MsrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002579">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
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        <property type="entry name" value="peptide-methionine (R)-S-oxide reductase MsrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46081">
        <property type="entry name" value="PEPTIDE METHIONINE SULFOXIDE REDUCTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46081:SF8">
        <property type="entry name" value="PEPTIDE METHIONINE SULFOXIDE REDUCTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SelR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MSRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MsrB" evidence="6">
        <location>
            <begin position="10"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PCH44283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="138" mass="15145" checksum="7B85CEF685FE99B6" modified="2018-01-31" version="1">MSDPSKQKSESEWRAILSPEQFRILREKGTEPAGTGKYEHFKGQGIYTCAGCGTPLYKSTTKFDSGCGWPAFFDAIPGAVSRQEDRSFGRIRTEITCTACGGHLGHVFQGEGFDTPTDERHCVNSVSINFAEDEKAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JWU6</accession>
    <name>A0A2H3JWU6_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RraA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_138300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KB468146">
        <property type="protein sequence ID" value="PCH43379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JWU6"/>
    <dbReference type="STRING" id="742152.A0A2H3JWU6"/>
    <dbReference type="OMA" id="FTVRCPP"/>
    <dbReference type="OrthoDB" id="1476984at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047443">
        <property type="term" value="F:4-hydroxy-4-methyl-2-oxoglutarate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008948">
        <property type="term" value="F:oxaloacetate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16841">
        <property type="entry name" value="RraA_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.40">
        <property type="entry name" value="Ribonuclease E inhibitor RraA/RraA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005493">
        <property type="entry name" value="RraA/RraA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036704">
        <property type="entry name" value="RraA/RraA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33254">
        <property type="entry name" value="4-HYDROXY-4-METHYL-2-OXOGLUTARATE ALDOLASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33254:SF4">
        <property type="entry name" value="4-HYDROXY-4-METHYL-2-OXOGLUTARATE ALDOLASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03737">
        <property type="entry name" value="RraA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89562">
        <property type="entry name" value="RraA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="97"/>
            <end position="100"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR605493-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH43379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="234" mass="24621" checksum="FC7101B179EA2D0B" modified="2018-01-31" version="1">MSSTLLSSLAKYSTCELSDALIKIGLPHGGHIPDIRMLSPRPGPADVRVCGPVYTVQMVMASDKNAPKPAAHFVDTAPEGSVIVIDAPPHTKNAVWGGLMTAGAKARGALGVIISGRCRDLAEHRSAGFPVFARGNSTLGQSPFTRPSAVNVPITIVPQDTGSGDRAVDFPAIRVEPGDYVVADEDGVVCVPRGMLETVVQMAAKGREIDSRCMEDIVAGTGVQEAFKRHRGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JWZ1</accession>
    <name>A0A2H3JWZ1_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">L-2-hydroxyglutarate dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="7">1.1.99.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WOLCODRAFT_71100</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(S)-2-hydroxyglutarate + A = 2-oxoglutarate + AH2</text>
            <dbReference type="Rhea" id="RHEA:21252"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:16782"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="EC" id="1.1.99.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the L2HGDH family.</text>
    </comment>
    <dbReference type="EC" id="1.1.99.2" evidence="7"/>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH41244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JWZ1"/>
    <dbReference type="STRING" id="742152.A0A2H3JWZ1"/>
    <dbReference type="OMA" id="GVHFTRM"/>
    <dbReference type="OrthoDB" id="498204at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047545">
        <property type="term" value="F:(S)-2-hydroxyglutarate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43104">
        <property type="entry name" value="L-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43104:SF4">
        <property type="entry name" value="L-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="9">
        <location>
            <begin position="7"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00036066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PCH41244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="437" mass="48478" checksum="85CA538ADC9350F3" modified="2018-01-31" version="1">MISGNPGVVGLAIARQLVQRFPSKSTFLVERHGRAGEETSSRNSEVIHAGLYYPANSSKTQLCLRGRHLMYEYCQKHNVPHKKVGKLVVARNDQRSYIEGLHAKARRLHWPDHSPPELKRVQALPTELIDGDRARELEPDLSRDIVAALWSPETGIVDSHALMECLEKDITESGGGELAYQTRVVRVDPHEAGTADPSDRGWVVQTVTGNSEGDGDALLARTLINCSGLSAHLVLNALLPKRSRVPMYYGRGSYASYRGPGVQSISHLIYPCPDTGRTIHGFQSLGTHLTLDLQGKIRFGPDLDWLDPPTIRRDDNTFVDDADPDFWQKHLIPDETRLGMMYEAVKDYLPGVDLSGFQPDYCGVRPKLVGPQGGFNDFEFRTHYPETFLGIQGHQDKVRQPMISLLGIESPGLTSSLAIAEMVVEDMLCAQNGHEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JYB2</accession>
    <name>A0A2H3JYB2_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">cystathionine gamma-lyase</fullName>
            <ecNumber evidence="4">4.4.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Gamma-cystathionase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WOLCODRAFT_133458</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD-104</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-homocysteine and L-serine: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.1" evidence="4"/>
    <dbReference type="EMBL" id="KB468168">
        <property type="protein sequence ID" value="PCH44993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JYB2"/>
    <dbReference type="STRING" id="742152.A0A2H3JYB2"/>
    <dbReference type="OMA" id="YKQDGVG"/>
    <dbReference type="OrthoDB" id="3512640at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004123">
        <property type="term" value="F:cystathionine gamma-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019343">
        <property type="term" value="P:cysteine biosynthetic process via cystathionine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000008">
        <property type="entry name" value="Cystathionine gamma-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000009">
        <property type="entry name" value="Cystathionine gamma-synthase homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054542">
        <property type="entry name" value="Cys_met_metab_PP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808:SF15">
        <property type="entry name" value="CYSTATHIONINE GAMMA-LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="TRANS-SULFURATION ENZYME FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="5 8 9" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PCH44993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="430" mass="45966" checksum="92A65AF30EC9A126" modified="2018-01-31" version="1">MSPSILNGIKKPHGDSFGTRAIHVGSDPSPETGAVIPAISLSTTYKQNGVGNHKGFEYSRSGNPNRNALEATLASLEAGGAYALGFASGSSTTATVLQSLGPNAHIVSVNDVYGGTFRYMSRVAKENQGLETTFVDLENADDETISAAFRPNTKLVWIESPTNPTLRLVDITRIVSLARAAPSSPLVLVDNTFLSPFYSSPLLQGADIVMHSLTKYVNGHSDVVMGALILPAGHEALVEKLRFLQNAIGAVPSAYDCWLAQRGAKTLHLRMKTHGTNALAVARALERSPYVEEVIYPGLASHPRNDLAYRSLSPHARKFVDQYMTRDDEGGFPYSGMISFRIRGGAEEANKFLTTTRLFTLAESLGGVESLAELPAQMTHGSIPPAERALLGIGDNLIRLSVGVEDEDDLVADVEQALAAAVGVGHKHYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JYR0</accession>
    <name>A0A2H3JYR0_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Nucleoporin NSP1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Nuclear pore protein NSP1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Nucleoskeletal-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">WOLCODRAFT_137296</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Nucleoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the nucleoporin NSP1/NUP62 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH41287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JYR0"/>
    <dbReference type="STRING" id="742152.A0A2H3JYR0"/>
    <dbReference type="OMA" id="EMMSKQV"/>
    <dbReference type="OrthoDB" id="344345at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044613">
        <property type="term" value="C:nuclear pore central transport channel"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000040">
        <property type="entry name" value="Nuclear pore glycoprotein p62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026010">
        <property type="entry name" value="NSP1/NUP62"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025574">
        <property type="entry name" value="Nucleoporin_FG_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007758">
        <property type="entry name" value="Nucleoporin_NSP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12084:SF0">
        <property type="entry name" value="NUCLEAR PORE GLYCOPROTEIN P62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12084">
        <property type="entry name" value="NUCLEAR PORE GLYCOPROTEIN P62-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05064">
        <property type="entry name" value="Nsp1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13634">
        <property type="entry name" value="Nucleoporin_FG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="9" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin NSP1-like C-terminal" evidence="16">
        <location>
            <begin position="452"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="167"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="236"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="514"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="15">
        <location>
            <begin position="22"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="93"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="170"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="186"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="236"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="265"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="304"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="333"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="363"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="407"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="430"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00068864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00078941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00081079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF05064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PCH41287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="663" mass="65089" checksum="497B291D63F5B6F7" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JZQ2</accession>
    <name>A0A2H3JZQ2_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitinase</fullName>
            <ecNumber evidence="2">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">WOLCODRAFT_89691</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the glycosyl hydrolase 18 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="2"/>
    <dbReference type="EMBL" id="KB468124">
        <property type="protein sequence ID" value="PCH42234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JZQ2"/>
    <dbReference type="SMR" id="A0A2H3JZQ2"/>
    <dbReference type="STRING" id="742152.A0A2H3JZQ2"/>
    <dbReference type="OMA" id="GTTCFAY"/>
    <dbReference type="OrthoDB" id="6020543at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12215">
        <property type="entry name" value="ChiC_BD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02877">
        <property type="entry name" value="GH18_hevamine_XipI_class_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045321">
        <property type="entry name" value="Cts1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050542">
        <property type="entry name" value="Glycosyl_Hydrlase18_Chitinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708">
        <property type="entry name" value="ENDOCHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708:SF49">
        <property type="entry name" value="ENDOCHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="3" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="7 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 9 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013635323" description="chitinase" evidence="12">
        <location>
            <begin position="27"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="13">
        <location>
            <begin position="42"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="344"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="346"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PCH42234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="478" mass="50498" checksum="14CB4C06F0E04605" modified="2018-01-31" version="1">MVLSRSSSAFWLGLSALASGLLPAYAYDNSASDNRRDAPYLHCHNSYWGQNSYGATGTNTAYYQQNLSYYCQDDVINAFPIAFLNVFFGEGGEPSIDLANICSTANDPVFEGTQLPVCTFMASDIETCQSAGKIVTISLGGATGSAGFSNESQAEEFANTIWNLFLGGSSDIRPFGDAVLDGVDLDIEGGSTEYFTNFVSTLRGLMNGGDKSYYLTAAPQCPFPDAYIGSVINAESFDAIYVQFYNNYCELTNYDDSNDWDYSTWDNWAKNTSPNPNVKIYIGAPAAQAAAGSGYVDAATLGAIAVATQENYSSFGGIMLWDASQAYANDRYDEAVKSYLTGGSGASTTTTEAVVPPTTTATATSSTPTTTSSTPTTTSSTPTTTTTASTGDCAGVAAWVANVAYTAGDQVVYNWTDDGTCTTTGVAVGTFVKVAYQSKEAPLNVGPKVSAVPNLSLSSALAAKTAPPTRRNSRFFRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K000</accession>
    <name>A0A2H3K000_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alcohol acetyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_152361</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468124">
        <property type="protein sequence ID" value="PCH42334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K000"/>
    <dbReference type="STRING" id="742152.A0A2H3K000"/>
    <dbReference type="OMA" id="HEECRSH"/>
    <dbReference type="OrthoDB" id="2150604at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052058">
        <property type="entry name" value="Alcohol_O-acetyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010828">
        <property type="entry name" value="Atf2/Sli1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28037">
        <property type="entry name" value="ALCOHOL O-ACETYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28037:SF1">
        <property type="entry name" value="ALCOHOL O-ACETYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07247">
        <property type="entry name" value="AATase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH42334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="408" mass="44561" checksum="5A26F7C7D42DE3E4" modified="2018-01-31" version="1">MHSGDPADAQATPLREAGLLHIARHHLGMYSCDEPTLFRTLARVIVHRHPALCVRLTGGADGRPTYTRLPQIDLTQIVTFTDTDESWGRVVIFAWHDGIGDGASGVAFHRALLSALQATEIPVHEVRALVSVPEDISLIPPLESLADLSVSLVKVCREVMLPTSWTPLDSAWTGRPVPQQDTSAANVRLLGYSPEETSRILHLCKSHHATLTSVLHTRGVRKSVHVDPCLAALLDAPADEMCDEVSMHHAYPLIMTRPPKHTSWLAALPWDTATDPAVTLQNQAQQATEQVSMLKFLFGNYDGYFKGMLGKKRKLSLQLSNLGRFPAREQGASGESSQSEAATWEATDMYFTQAQSASLAAITVNITGTPKRGLGLTITYNPNAVDDAFGESFFRQLNVALDEMAQLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K0M3</accession>
    <name>A0A2H3K0M3_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Class I glutamine amidotransferase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_102344</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468124">
        <property type="protein sequence ID" value="PCH42554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K0M3"/>
    <dbReference type="OMA" id="FTDEWYD"/>
    <dbReference type="OrthoDB" id="3482285at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029010">
        <property type="entry name" value="ThuA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40469:SF2">
        <property type="entry name" value="GALACTOSE-BINDING DOMAIN-LIKE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40469">
        <property type="entry name" value="SECRETED GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06283">
        <property type="entry name" value="ThuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ThuA-like" evidence="1">
        <location>
            <begin position="8"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH42554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="253" mass="27980" checksum="7BA435D326B30BB3" modified="2018-01-31" version="1">MSQQSTARILIYTATRGYRHDSIPASVEALFAKASSINVQFDHTEDQTWFTDERLKTYDALLFLNNSGEILDEPGKAAFQRYLDSGGNFIGVHCASACLYNDEFFKKEVGALFDYHPDICNAVFDVVDPSHPSTSMLPARWELYDEVYNFMSDPRGVGATIILTADESTYSDPGERKYDHGTPHPTAWFQERGAGVQPGGVAGRSFYTSLGHCIETWQDELFLAHVLGGIQWAIQSGTTKAFNPNALVGNSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K1D6</accession>
    <name>A0A2H3K1D6_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6314 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_165540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
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    </reference>
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    </dbReference>
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        <location>
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            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="238" mass="26473" checksum="A1EA0CEDA67B4772" modified="2018-01-31" version="1">METQRHAPPSTVTDDGRACSCSTSSTSCASNTDPSQIASDPEILFRSLAGEWRARRTIRHLGSKSKGVDGIFGGTASFYLRAPTADEPEEGMQEYLYHEHGTFTTSTGASFPAQMKYIYRYHPMSRRISVWRVKPGASVAPPNAGEVENWFHDIILTTSSELQGSAWFTDYRRAGDCIFKGSEHLCVRDLYKPFYKFCFGGDELVEFGIGYEVSGPGKDYTSEAWFMRPPANGLSPQM</sequence>
</entry>
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                <person name="Kallen N."/>
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                <person name="Nagy L.G."/>
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                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
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    </dbReference>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="111" mass="11506" checksum="50B94361DDE7E166" modified="2018-01-31" version="1">MGGGGSRDGCNEWAAQGEWGHADWGVMHAGMGTACFKATAMAGLGNEVGGSPSPLSAVALPPPQLSSLSPMPVHYAYHTEWLPHPTRQAPYRAALCAAPVPRAHQSFKPSG</sequence>
</entry>
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                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
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                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
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                <person name="Sabat G."/>
                <person name="Salamov A."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468146">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
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    </dbReference>
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        <property type="entry name" value="Mito_Persulfide_Diox"/>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="64"/>
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    <feature type="region of interest" description="Disordered" evidence="2">
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    </feature>
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        <location>
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            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH43854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
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        </source>
    </evidence>
    <sequence length="339" mass="37876" checksum="2957AB86B2850484" modified="2018-01-31" version="1">MPYVLDPTRGLSTTTPSHTAASTSGQTSSILLKRNVPPAEPWRRHISPDAATPTVFTFFEKATSTWQYIVVDPHTSDAVVIDPVLDYDASSGSITTQTADGLLSFIEHERLTVRRILETHAHADHLTAAQYLKQQLGQHIPVCIGQRITQVQKTFAPKYGFDDPSVFDNTFDCFFKDDEEFKLGQLCCRVMHLPGHTPDHVGYLIGKAVFTGDSIFNPDVGSARADFPGGNAEDLYASMQRLLSLPTAYRLFVGHDYPQDRDQTCWSTVEEQRERNKHLKLGTDAETFIKWRKERDAVLGAPKLLHPSLQVNIRAGKLPPKDAQGRVFFKIPITSEVDV</sequence>
</entry>
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    <accession>A0A2H3K4B0</accession>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
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                <person name="Blanchette R.A."/>
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                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
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                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
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                <person name="Gaskell J."/>
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                <person name="Hori C."/>
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                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
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                <person name="Kumar T.K.A."/>
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                <person name="Martin F."/>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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                <person name="Nagy L.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6 7">MD-104</strain>
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    </dbReference>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
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                <person name="Barry K."/>
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                <person name="Martinez A.T."/>
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                <person name="Kallen N."/>
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                <person name="Kohler A."/>
                <person name="Kuees U."/>
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                <person name="Lindquist E."/>
                <person name="Ling A."/>
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                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
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                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
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                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
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                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SH3YL1 family.</text>
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                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH34162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3IVZ3"/>
    <dbReference type="STRING" id="742152.A0A2H3IVZ3"/>
    <dbReference type="OMA" id="LACEYTE"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH34162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="497" mass="56003" checksum="13A2D94D8FD8D1B9" modified="2018-01-31" version="1">MGFLNVQQDAADFDLVHRFRLDNLGVLLTAPDGTEATEARISVMLWPGYTYRVSRYYSKTGKSSLRLALYLLPGDMAFPPLSVNATVTVQSLSGDIVYSTQSPRRPSIFEQGRAIIGTLLTQKMYEASERMQHEDAVSVLVTLRPSNEPNPRSKPTLDLIHRVLTAQPISNTRFVVFSRRDSFGRLSSPRSFYANMKDLASTYERSESLLNVESMIEGFELQRGSCLSDYNLACEYTEYDSDFEPDEDEDDEDGDMVVVRGSGRDWRGSRASARRPARLVEPLIASEESITRESSQDRAMQMRGDEEAQGDMISSTTSFDMVDDKHEERSDLHTGSTYDGTTIVLLGTASKTWEALLYYLYTGIITFSPLRPRNATTCVDEDMWYHADGADEPAKPSCRSIYRLATKLELHGLRRIALQYLQSQLTPQTLLTEVFSEFTARYAEVKEMELALVVQYWDILKSSSAFKEKMVEVTSGKVPHAAEILSEIMLRVSAKQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IWJ9</accession>
    <name>A0A2H3IWJ9_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Cysteine proteinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">WOLCODRAFT_135516</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH34121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3IWJ9"/>
    <dbReference type="STRING" id="742152.A0A2H3IWJ9"/>
    <dbReference type="OMA" id="QLRRFKC"/>
    <dbReference type="OrthoDB" id="10263353at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02669">
        <property type="entry name" value="Peptidase_C19M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000068">
        <property type="entry name" value="U4/U6.U5 tri-snRNP-associated protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033809">
        <property type="entry name" value="USP39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF16">
        <property type="entry name" value="U4_U6.U5 TRI-SNRNP-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00290">
        <property type="entry name" value="ZnF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBP-type" evidence="13">
        <location>
            <begin position="73"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="12">
        <location>
            <begin position="198"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="10"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PCH34121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="541" mass="60860" checksum="F2EDEFDC9365E7D6" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IWM9</accession>
    <name>A0A2H3IWM9_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_15277</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH34356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3IWM9"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH34356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="103" mass="11564" checksum="ABA734AF57734DE9" modified="2018-01-31" version="1">MSHEPTVSPPAGVPTWSYKLPGVYDTFTDTAENNGTYQDRKRYESKDRQGAEQHWMSSILQLVLSDAESQSPIYVHHSQTECPALPAHVTPEEMYESPALLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IWV8</accession>
    <name>A0A2H3IWV8_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_142151</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH34452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3IWV8"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH34452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="116" mass="12872" checksum="C4498FAAF5EA94FF" modified="2018-01-31" version="1">MNNSRARHGNVTLDLPRCLRLNRSQAIGHNMVQPPAMFRTLHTPISLPRGGNLAELCLLPIKDLHKSSAQVLMGLLLPNLSSALRVPQIRMAYEGTVLLKYLRLRGVRVLSAMGIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IWZ2</accession>
    <name>A0A2H3IWZ2_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_160480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH33955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3IWZ2"/>
    <dbReference type="STRING" id="742152.A0A2H3IWZ2"/>
    <dbReference type="OMA" id="MADNIFV"/>
    <dbReference type="OrthoDB" id="2142040at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34706:SF3">
        <property type="entry name" value="ANKYRIN REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_7G06200)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34706">
        <property type="entry name" value="SLR1338 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="36"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="69"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH33955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="494" mass="54270" checksum="7B03E437566F0137" modified="2018-01-31" version="1">MAGLHEEALQGTLTAASLKQYLAQDSSAIDAIGGPKSVTPLAAAVSRGKLETVRLLLNANADPNALSSHGRTPLYFATVRAPTADRAAIVRELLNAGADIDGECDEDDRSTPLMNAIVETRDRDVIRELVNRGASQTKANVRGETAKSLAKDMDMEHVLRGKDATTLNLAQIIDLIVTVVLAIIAYVNNPVVNEVLDKVLEKRYGISGKIDTDLDEDLHHPQTDQQLTTELDNYVKTSGLEKFFAPGDTFLQTLAERATILRNDRTTTLGQPGNIERLTRLSLYQSVVYCDDSGSMSFDSRYDSQRELVTRIARIATKIVPDGTGIELRFINSASSSNLTAEEVDAAVAAVSPGGGTRIGMTLRQKILQPLVYDVIERGQKLQRPLLVCAITDGCPMGEPTDAFKRVIIDCRRRLVDHGYEPNAVTFCISQIGNDKTAAEFLDMLARDPDIRDALYVTTDRLDSKFQEMRGNESRLEEWLLKTLTMPIMEGVEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IXH2</accession>
    <name>A0A2H3IXH2_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_155307</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467832">
        <property type="protein sequence ID" value="PCH34656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3IXH2"/>
    <dbReference type="STRING" id="742152.A0A2H3IXH2"/>
    <dbReference type="OMA" id="QWITRIE"/>
    <dbReference type="OrthoDB" id="2800501at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH34656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="323" mass="36498" checksum="1497566AAFA58E2E" modified="2018-01-31" version="1">MGITRRLYLHVFQLDVPLPDLIHEVYDYAERKNRYSPDCWPIEDLRRRRDNPSEVDCNVDPISAWTIISQDSSLVKLAILVLSFVPNSASTERLFSSMGHTKTKMCSRLGIQKNRDIAFLKMELRRRHAEEGTARKRLKQRFGNTETSVDCDKSGSRLSDEQLLQEAEGCSLSSSNDDSDEEGADNEAETDNKAETGEASEHPKCSQFLKSVQALEAAANVDSDDEDVGGVVEQAASDGSMRRASAIIIRCFFGQKYLFTIHELFNWSIEAGWDEFWTQGVRNYREEVVFYELMSRVHEDSPQSSSTAITKYSDAAPIVVDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IY06</accession>
    <name>A0A2H3IY06_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_133632</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467832">
        <property type="protein sequence ID" value="PCH34846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3IY06"/>
    <dbReference type="STRING" id="742152.A0A2H3IY06"/>
    <dbReference type="OMA" id="LPHRHGA"/>
    <dbReference type="OrthoDB" id="5399006at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43431">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT CHAIN DEHYDROGENASE/REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G14000)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43431:SF7">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G14000)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH34846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="244" mass="26358" checksum="B7B4908A79D0E4FC" modified="2018-01-31" version="1">MSSIRPIIVIAGIGNGSGTGAATARVFAKTGYRVALIARNADHLNKVVTELTQAGGEAAAFPIPGYSYGAVTSVVENIRKYQWPSGGKSEIRVGLWNTGAGVWKGFLDVTEQDLQTVIILAFQENEVDALGKRGTLLFTGATASIRGNVTTSAFAAGKFALRALSQSLNKEFGKQNIHAIIDGGILTDLSLSRRSDPQASKEWQENANIRLDPESIGKAYFYLASQDKSSWTWELDLRPAHEKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IYE1</accession>
    <name>A0A2H3IYE1_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycoside hydrolase family 5 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WOLCODRAFT_106510</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467832">
        <property type="protein sequence ID" value="PCH34761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3IYE1"/>
    <dbReference type="STRING" id="742152.A0A2H3IYE1"/>
    <dbReference type="OMA" id="CKMLHTE"/>
    <dbReference type="OrthoDB" id="1887033at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000130">
        <property type="entry name" value="Endoglucanase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF13">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="5">
        <location>
            <begin position="77"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PCH34761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="477" mass="55793" checksum="5D60D4836D52AFC1" modified="2018-01-31" version="1">MASVLKVSGRKIVDGSGEEVILRGAGLGGWMTMENFITGYPGCEFQIREALAEVLGKEKSEYFFDRFLEHFFAEPDAAFFKSLGLNCIRIAISYRYFEDDMKPCVLKPEGFKHLDRAVAACAKHGIYTILDMHTAPGGQNGGWHSDHGDHLSSFWTHKDFQDRLVWLWTEVARHYKDEKWIAGYNVMNEPADPQHSGLVTFYDRVYAGIQSVDPNHMLFFDGNTFASDFSGFPDDAATRWPNAAYAIHDYSLFGFPRSPEPYERTDEQRRRMRRSYEKKREWLDERGLCVWNGEWGPVYAREEYDGEVTSAVNERRYNVLNDQLEMYRKDRLSWSIWLYKDIGFQGMVYVSRETPYMALFKDYLHKKYRLAVDAWGADDRFVRHIYDPIVDLIKAEVPNEADRRLYPYPIWTLERRVEVLARNILLGEYMVREWAEHFRGLEKPDLERLAESFKFENCMLRDGLNRVLRAHAPTASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IYH6</accession>
    <name>A0A2H3IYH6_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_139697</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C14B family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467843">
        <property type="protein sequence ID" value="PCH35032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3IYH6"/>
    <dbReference type="OrthoDB" id="3223806at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050452">
        <property type="entry name" value="Metacaspase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104:SF30">
        <property type="entry name" value="METACASPASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104">
        <property type="entry name" value="METACASPASE-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="114"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="161"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="114"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="139"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="177"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH35032.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="377" mass="43030" checksum="2A7E73ED724A93B1" modified="2018-01-31" version="1">MDHGGLEDRDKLIVDNDLRKLLVDPLPVGAYLTAVLDSCHSGTLLDLKHYRCNTIYLPWVANGERKLRSRWENVVRKDATPPTPRKPAPLPALTRVPTFTDMMKTLGRPLRKTSAQLQRSLSLRRTPSLSIKRTPTVHSTASTETALTETASIGTAVELPALPRAHSQPQSSPCWWRGKEEKKDEKKGEKSKESEKIKEEKSREKKDKEMGKEKLRGLEKDKEKKGRGLIRELSFRLKTALEIAIPQCTSPTSTVRECDGHCLASPTEKPHVISIAACTDRQLDWEDPQGMSMTRALIKQLREHPNATLAEIMTTISYHNYEVTCKFKSARKQWLRCHRPKEEVETGSFPELFEYQDLQLGSQERLDLHTQFQDYVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
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    <name>A0A2H3IZQ2_WOLCO</name>
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            <fullName evidence="3">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="1" type="ORF">WOLCODRAFT_78937</name>
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        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467832">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3IZQ2"/>
    <dbReference type="OMA" id="CKKSFFI"/>
    <dbReference type="OrthoDB" id="2768905at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH34925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="150" mass="17232" checksum="E510E1A8151F9982" modified="2018-01-31" version="1" fragment="single">MLTVAPRATPPPAFSGEGKDNVEEWLFKVHVYHGHMKYTTDRERIGDALTRITGTAFKYFTNLQEKYSTGGNIGTWEEFEKQLKCTYEKKTQKEVAQSELDKHFSGDAGIARCKKSFFIYCEEFRQLAKLMGYENASLQKKLEDTLLADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IZU1</accession>
    <name>A0A2H3IZU1_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
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    <gene>
        <name evidence="4" type="ORF">WOLCODRAFT_166287</name>
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    <organism evidence="4 5">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467854">
        <property type="protein sequence ID" value="PCH35492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3IZU1"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="452"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="341"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="259"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
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            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="343"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="439"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PCH35492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="541" mass="59854" checksum="4314524AF6B50479" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J081</accession>
    <name>A0A2H3J081_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
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        <name type="common">Brown rot fungus</name>
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        <lineage>
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            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467854">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J081"/>
    <dbReference type="STRING" id="742152.A0A2H3J081"/>
    <dbReference type="OrthoDB" id="3230070at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
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        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH35586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="230" mass="26215" checksum="C6F5734978DDE2A2" modified="2018-01-31" version="1" fragment="single">SDVLKTHPNTTVIHYFTNNTTALRTIYSTHNHPTQTNSILFITHTDSLLCAHPNLTIILHWCPSHKGIPGNKSADCLAKHATTLPSSHPSTLTWLRQHVKRQALQCWQREFHSTPNINRHYTHTLFPPSNTLHPTLRKFTGTRNVQSRIIHCITAQGHFSEYYSRFVPTETTSCPCDTHTLISKMQTLISTRHHLTRISPSITLHILLSTPKGLQALQRFLEHSTAFLKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J142</accession>
    <name>A0A2H3J142_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="2" type="ORF">WOLCODRAFT_140122</name>
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    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467865">
        <property type="protein sequence ID" value="PCH35906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J142"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH35906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="183" mass="20237" checksum="CE1BA43CC3FA168A" modified="2018-01-31" version="1">MTGATVLLFFNKCLLLLLTISNVLNILNWGSDQSCDAQIVLQEVLFILSTTIAAALSALRVYAVGERSWFWTLLTLLAGLVPAAADSYLNASAGRPYVAFAAGLPVCMRHNVFSRIVYNRFIIASLVCAIVSDLIVIGATWMYAMPWARRVSETQIKRPLMLVILRDGIGYFIILLLNHITRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J144</accession>
    <name>A0A2H3J144_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WOLCODRAFT_64004</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH33503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J144"/>
    <dbReference type="STRING" id="742152.A0A2H3J144"/>
    <dbReference type="OMA" id="AGMFWLH"/>
    <dbReference type="OrthoDB" id="40134at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF479">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="262"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="304"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="344"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="374"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="417"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="79"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PCH33503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="456" mass="49333" checksum="6CC09D7A3281D068" modified="2018-01-31" version="1">MSEKQQSKHVVFEKSDVFGYEEDHDIQYKTLSWQFVAFLMIAEIVSNGMLSLPNAMAAVGEYQEDYGKGRATDMLLVGTGIVPSLILTIFLGVFGLFTAKLLVDFKLNHPDVHNMGDAGYLIFGPIGREVLSVGTMIFAIFGTGSELLSGQLALSSLSNNGLCATVLLAIFSAATFLVALPRTLGRLSWLGLISTISITLCGVLAMIGAGVSPAASRTIAATVPNSFYEAFLAITGPVFAYAVHRFFILISEMRRPEDAMKAAWTLQVFATAYYAVFSVVVYVYLGSTVQSPALLSLSSVWSKVTFAAGLANFLISGGLYAHTAAKLIFVRFFRRSRHLYSHTFLGWFVWTILCFAATAIAFIFAAAVPIFSDLVSISASLFASWYTYGIAGFFWLHDAYHLDGKKEALVRRWGGTLLAVLTISAGAFICVAGTYVSVKLIVEAYASGAVGRPFSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J153</accession>
    <name>A0A2H3J153_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">COX assembly mitochondrial protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WOLCODRAFT_61139</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for mitochondrial cytochrome c oxidase (COX) assembly and respiration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the CMC family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH33513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J153"/>
    <dbReference type="STRING" id="742152.A0A2H3J153"/>
    <dbReference type="OMA" id="MLQQDGK"/>
    <dbReference type="OrthoDB" id="6224010at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013892">
        <property type="entry name" value="Cyt_c_biogenesis_Cmc1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08583">
        <property type="entry name" value="Cmc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU364104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PCH33513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="60" mass="6772" checksum="F99260FC2DBE4EB8" modified="2018-01-31" version="1">MSTLSRREEETLLKTAKTKALKECDTVVKEFADCATGRTLTVAWACKDKYKAVQDCMLQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J2J1</accession>
    <name>A0A2H3J2J1_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_20224</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467865">
        <property type="protein sequence ID" value="PCH35925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J2J1"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="176"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH35925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="416" mass="44248" checksum="F51BD43D65F9D9F9" modified="2018-01-31" version="1">MVAIAANKGIEWNPLDVFSSLSRRLDRNVVDETLPRTPSSWSPSIKGTRRAWTKTRSAAPTADAEGGADYVRTVAEASLGAKLGYVWLRAGAGLAADATEPVDVTITTAVAISVGSRVPCGEAGTAIAYQKPEGKPGASTQPEGEPGTEPEPGDGAAPAVPAIHPSVAITVTDKNLSPPQSRSQGGSPLGNEERLALPPVEALKHNGGSEPEEDDNIDDSDDVEEVKLEMKQEEEESSGNLAEAKEELGVHEEEEEESSDQNSAGDGGSEGEGKIDQLESDDELPEENSIQTMRRQRPLQSGSKGKEKAVEAEIHLMASSSKLRPPIPSREQANRVLQTVHRPVLPGNFSVDSRHRESRPDQVSIQGATPLYAAGSSRPPTKLPGNYQISFGISMQEGGVPLVTSLWEDMQAILYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J2U9</accession>
    <name>A0A2H3J2U9_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Prefoldin subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WOLCODRAFT_156756</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467865">
        <property type="protein sequence ID" value="PCH36035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J2U9"/>
    <dbReference type="STRING" id="742152.A0A2H3J2U9"/>
    <dbReference type="OMA" id="KFGRAIN"/>
    <dbReference type="OrthoDB" id="10250441at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd23165">
        <property type="entry name" value="Prefoldin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000005">
        <property type="entry name" value="Prefoldin subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016661">
        <property type="entry name" value="PFDN4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21100">
        <property type="entry name" value="PREFOLDIN SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21100:SF9">
        <property type="entry name" value="PREFOLDIN SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016477">
        <property type="entry name" value="Prefoldin_subunit_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="27"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR016477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PCH36035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="131" mass="15414" checksum="D8CE3D0E445C07E2" modified="2018-01-31" version="1">MRILSQEEEHDDNAEVTWEDQQRINTFSKLNTRLRGIEERITTLKQEKEALDDLSMELELADEDEPVMYKVGEVFLHLSHSRAMNRLEKDQNELNSELSNLTDRAEECEKSMKELKVILYAKFGRAINLDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J3A2</accession>
    <name>A0A2H3J3A2_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_157435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467887">
        <property type="protein sequence ID" value="PCH36730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J3A2"/>
    <dbReference type="OrthoDB" id="2803685at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH36730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="242" mass="26749" checksum="C9D7C05D3BF50875" modified="2018-01-31" version="1">MRQPRPRRSPIHDDDAQAEMRTRVPLSASTTALPTLASAPSHTHLAASLSASTPHLLASASHDPAALKPPIYLLTPDHVARIAYFPPATASPQRGMNTDIRFVRPGSGRPATALSLDLLAPILPPPIQPDPHTPLSELTPTNLSMQFVFPPSRDLRTARGEDTSGVLGKLRTRTKRLGLNFRLLHPRPKARTAQTDHEQAWQDEQHRAHLCWRCRKAGGRRKDCRAFRRPGYSEGLAAEMYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
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                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
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                <person name="Kumar T.K.A."/>
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                <person name="Lindquist E."/>
                <person name="Ling A."/>
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                <person name="Lucas S."/>
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                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
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                <person name="Stenlid J."/>
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                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J4P6"/>
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    <dbReference type="OrthoDB" id="3227562at2759"/>
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            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="198"/>
        </location>
    </feature>
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            <end position="193"/>
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    </feature>
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    </evidence>
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            <dbReference type="EMBL" id="PCH33719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
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                <person name="Spatafora J.W."/>
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                <person name="Benoit I."/>
                <person name="Boyd A."/>
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                <person name="Ferreira P."/>
                <person name="Findley K."/>
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                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
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                <person name="Kohler A."/>
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                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
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                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
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                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
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                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
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                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
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                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
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            </authorList>
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        </source>
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    </evidence>
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    </evidence>
    <sequence length="523" mass="56106" checksum="6C2160EED2FC0914" modified="2018-01-31" version="1"> </sequence>
</entry>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
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            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">MD-104</strain>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <comment type="function">
        <text evidence="5">Catalyzes the NAD(+)-dependent oxidation of formate to carbon dioxide. Formate oxidation is the final step in the methanol oxidation pathway in methylotrophic microorganisms. Has a role in the detoxification of exogenous formate in non-methylotrophic organisms.</text>
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    <comment type="catalytic activity">
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            <text>formate + NAD(+) = CO2 + NADH</text>
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            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.17.1.9"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.17.1.9" evidence="2 5"/>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH37802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J6B4"/>
    <dbReference type="STRING" id="742152.A0A2H3J6B4"/>
    <dbReference type="OMA" id="ENYHMIS"/>
    <dbReference type="OrthoDB" id="418179at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008863">
        <property type="term" value="F:formate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042183">
        <property type="term" value="P:formate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05302">
        <property type="entry name" value="FDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000057">
        <property type="entry name" value="Formate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03210">
        <property type="entry name" value="Formate_dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033689">
        <property type="entry name" value="FDH_NAD-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005750">
        <property type="entry name" value="PRK07574.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42938">
        <property type="entry name" value="FORMATE DEHYDROGENASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42938:SF9">
        <property type="entry name" value="FORMATE DEHYDROGENASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0520">NAD</keyword>
    <keyword evidence="3 5 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="7">
        <location>
            <begin position="63"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="8">
        <location>
            <begin position="156"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="201"/>
            <end position="202"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="257"/>
            <end position="261"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="338"/>
            <end position="341"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="5">
        <location>
            <position position="285"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="5">
        <location>
            <position position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PCH37802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="387" mass="42582" checksum="C07290B3E125A258" modified="2018-01-31" version="1">MFSRLATRPLATRPLARTLATPTKQWDRGMKVLAILYRGGEAARQEPRLLGTVENELGLRSWLESQGHEFIVSDSKEGPNSDLHKHITDAEVVITTPFHPGYLTRDLIDKAKNLKVCVTAGVGSDHVDLNAAVERKIQVLEVTGSNVTSVAEHVVMSILLLVRNFVPAHEMIERGDWQVSDVARNAFDLEGKVVGTIGAGRIGYRVLERLMPFDTKEHLYYDYNSLPAEAEKKVRARRVEDLKALVSQCDVVTVNCPLHEGTRNLVNADLLKHFKKGAWLVNTARGAICDKDAVAAALKSGQLSGYAGDVWNVQPAPKDHVWRTMKNALGGGNGMVPHYSGTTLDAQARYAAGTRSILENYLKGKPQEPANIIVGIGKYETKAYGQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J6H6</accession>
    <name>A0A2H3J6H6_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_93195</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the avfA family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH33258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J6H6"/>
    <dbReference type="STRING" id="742152.A0A2H3J6H6"/>
    <dbReference type="OMA" id="EHDKFSV"/>
    <dbReference type="OrthoDB" id="10254221at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016646">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051606">
        <property type="entry name" value="Polyketide_Oxido-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43355">
        <property type="entry name" value="FLAVIN REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43355:SF2">
        <property type="entry name" value="FLAVIN REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="2">
        <location>
            <begin position="7"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH33258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="222" mass="23557" checksum="52F97DD905BFF51A" modified="2018-01-31" version="1">MHLLILGGTGPSGIKLIEEALVASHTIVVYVRSPGKLPEAIASNPSVTVIEGQLTDVEKLTAALEGVHAVLSALGPPTKTGPVYPSNTPLAHAYAVVIDAMEQHGVKRLIALGTASIKDEHDKFSLIFAFLVSGVSIFAHNAYKDIVAVGETIRTRGAEADLDWTIARVPLLTDRESKDVVAGYVGDGRTKTTLSRAAFAAFVVEELEKNQWNRAAPLISSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J6I3</accession>
    <name>A0A2H3J6I3_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein mS38</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WOLCODRAFT_161115</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the mitochondrion-specific ribosomal protein mS38 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH37872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="742152.A0A2H3J6I3"/>
    <dbReference type="OMA" id="AMVVNRI"/>
    <dbReference type="OrthoDB" id="3268560at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013177">
        <property type="entry name" value="Ribosomal_mS38_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32035">
        <property type="entry name" value="AURORA KINASE A-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32035:SF3">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08213">
        <property type="entry name" value="COX24_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01155">
        <property type="entry name" value="DUF1713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal protein mS38 C-terminal" evidence="6">
        <location>
            <begin position="205"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="29"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="123"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="33"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="57"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="145"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00035647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PCH37872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="238" mass="26140" checksum="C694010D92843A83" modified="2018-01-31" version="1">MAFLGHLLRQVPAARRAYSVFSKPGGGRYFNSAKPPKVAPAPTKVDTASPPGDASAKDQSTQPSSAAVTPEGSSTAPTMPSLTPFMPVHPAINAHDLRLHQFFSLHRPLLHVSQPASTIFESAPDTFTWPPAPPAETANVNNLEDPPEASPEEDADAARQLARALVVNRLGASIAWEDTLQKLGLDVTESRAEEVRAAETEFEVYMDSVKRKRRKKMKKHKLKKRRKLQRALRIKIGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J731</accession>
    <name>A0A2H3J731_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DDE-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_78911</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467832">
        <property type="protein sequence ID" value="PCH34549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE-1" evidence="1">
        <location>
            <begin position="7"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH34549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="215" mass="23856" checksum="C903461E8997AD6D" modified="2018-01-31" version="1" fragment="single">VIITICGDGTSIALTVIFKGAGYQTSWVQDNPLNASIGYSKKGYTTGKIGAKWIKQLDAQTKDKAYGHWRLLPVDGHTSHYTKAFLDYTHAHQIVIICYPSHSTHIYQGLNVIIFSILKQCWSQARDKYELKTGEKVSKSNFLSSYGKAHLTALTAENIKAAFCKTGVIPFDRTVIHVETMVPSQTSLTQVYLPFQPPSPVQAVMHLLQARAVSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J7K7</accession>
    <name>A0A2H3J7K7_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GTP-binding protein ypt1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WOLCODRAFT_23190</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Preautophagosomal structure membrane</location>
            <topology evidence="8">Lipid-anchor</topology>
            <orientation evidence="8">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH38252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J7K7"/>
    <dbReference type="STRING" id="742152.A0A2H3J7K7"/>
    <dbReference type="OMA" id="TQMAKDF"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01869">
        <property type="entry name" value="Rab1_Ypt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000069">
        <property type="entry name" value="Ras GTP-binding protein YPT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057289">
        <property type="entry name" value="Rab1/Ypt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0636">Prenylation</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="175"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="175"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="192"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00060489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00074496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PCH38252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="205" mass="22550" checksum="3BD92707031FACA6" modified="2018-01-31" version="1">MHTSEYDYLFKLLLIGDSGVGKSCLLLRFADDTYTESYISTIGVDFKIRTIELEGKTVKLQIWDTAGQERFRTITSSYYRGAHGIIVVYDVTDNDTFTNVKQWLQEIDRYASEGVNKLLVGNKSDLTSKKVVEYSAAKEFADQLNIPFLETSAKNATNVEQAFLTMAKQIKDRMGASSSTVGGTGKSSTITPGTSVTQQSSGGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J7T0</accession>
    <name>A0A2H3J7T0_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_156526</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467865">
        <property type="protein sequence ID" value="PCH35833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J7T0"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH35833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="106" mass="11448" checksum="30677EE3B39840BC" modified="2018-01-31" version="1">MLDGFQCKRAIAALCCCPQAPSRKSLLAVEPALPTPPTSPLIFAATPRAEPPAEFSIADTPHLSSPADLLLDKEKLKGLYPEREEMFRSLSPSFFVGELLLSPAPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J7U4</accession>
    <name>A0A2H3J7U4_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WOLCODRAFT_135276</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH33708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J7U4"/>
    <dbReference type="STRING" id="742152.A0A2H3J7U4"/>
    <dbReference type="OMA" id="NFRQKDD"/>
    <dbReference type="OrthoDB" id="1913277at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039205">
        <property type="entry name" value="NDUFA11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21382:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21382">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PCH33708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="164" mass="16406" checksum="DAFA49FD5D000A54" modified="2018-01-31" version="1">MAENDPSASSAASESYEPKQALQAASAVGLQAAGVGAFVSAIQNALGSHSSGAAGVLTRTGGTIGFFAAMGATFAFTEAAVANNRQKDDAVNGAAGACAAGFLAGIRSRSLPLAIASCAVLGSVMGTFDYAGKALQTPVSQEERRQRFFKHTPPTHAAHSSASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J8P9</accession>
    <name>A0A2H3J8P9_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Barwin-like endoglucanase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WOLCODRAFT_135984</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH38005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J8P9"/>
    <dbReference type="STRING" id="742152.A0A2H3J8P9"/>
    <dbReference type="OMA" id="SPLCGKQ"/>
    <dbReference type="OrthoDB" id="406505at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22191">
        <property type="entry name" value="DPBB_RlpA_EXP_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051477">
        <property type="entry name" value="Expansin_CellWall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009009">
        <property type="entry name" value="RlpA-like_DPBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836:SF24">
        <property type="entry name" value="RLPA-LIKE PROTEIN DOUBLE-PSI BETA-BARREL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03330">
        <property type="entry name" value="DPBB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013957753" evidence="3">
        <location>
            <begin position="21"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="RlpA-like protein double-psi beta-barrel" evidence="4">
        <location>
            <begin position="108"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="87"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PCH38005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="209" mass="22446" checksum="A40042C17B201B38" modified="2018-01-31" version="1">MSRFLAVTTLACVAATTVSGRTIGARTTVPPTYDQGYLEPYATYHARYLALDCQDKHDTLFFESCCHPLLATQSLSDRPEECNPYPSSTSTSATSTLETTSDSEVYTDGYATYFYQNGVAGACGTVHSDYDMIAAIDQDRYGNSGAVSALCGQKVKITNPANGNTVTVTIADDCPTCRNSDSIDLSVGAFEQIADLSEGIVSIDWEFVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J901</accession>
    <name>A0A2H3J901_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_149682</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH38742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J901"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH38742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="183" mass="19912" checksum="A87706900A7D3FE5" modified="2018-01-31" version="1">MLLGALAPPRASARWPLSMQSAVRDQSTDSMLVECSLGMFNMLMIHRALRKTMWSVGSSYDTPRRVRLQRPCGSCAPFTALEACGAVRHLLRSRLSTWIADGAYETIRGRSTTRVSPRHPPVAFAFRDVNLESTPAYISVLAGRDQGIKCTAAIMSSDAHPSLLSADSGDEPAFTAIYRAPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J953</accession>
    <name>A0A2H3J953_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glutamate--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="3">6.1.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Glutamyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">WOLCODRAFT_129640</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.17" evidence="3"/>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH33184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J953"/>
    <dbReference type="STRING" id="742152.A0A2H3J953"/>
    <dbReference type="OMA" id="QAPRYDN"/>
    <dbReference type="OrthoDB" id="428822at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004818">
        <property type="term" value="F:glutamate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00808">
        <property type="entry name" value="GluRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000045">
        <property type="entry name" value="Glutamate--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00022">
        <property type="entry name" value="Glu_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045462">
        <property type="entry name" value="aa-tRNA-synth_I_cd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020751">
        <property type="entry name" value="aa-tRNA-synth_I_codon-bd_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008925">
        <property type="entry name" value="aa_tRNA-synth_I_cd-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004527">
        <property type="entry name" value="Glu-tRNA-ligase_bac/mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049940">
        <property type="entry name" value="GluQ/Sye"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033910">
        <property type="entry name" value="GluRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00464">
        <property type="entry name" value="gltX_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43311">
        <property type="entry name" value="GLUTAMATE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43311:SF2">
        <property type="entry name" value="GLUTAMATE--TRNA LIGASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19269">
        <property type="entry name" value="Anticodon_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48163">
        <property type="entry name" value="An anticodon-binding domain of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic" evidence="12">
        <location>
            <begin position="2"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class I anticodon-binding" evidence="13">
        <location>
            <begin position="359"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00072917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF19269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PCH33184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="513" mass="57551" checksum="ECB7732EC8711984" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J971</accession>
    <name>A0A2H3J971_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Meiotic sister-chromatid recombination aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WOLCODRAFT_135564</name>
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    <organism evidence="7 8">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH34198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J971"/>
    <dbReference type="STRING" id="742152.A0A2H3J971"/>
    <dbReference type="OMA" id="ILMRGTF"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="6">
        <location>
            <begin position="75"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PCH34198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="609" mass="67678" checksum="91CC61C264319B89" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J9C1</accession>
    <name>A0A2H3J9C1_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_15209</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH34258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J9C1"/>
    <dbReference type="STRING" id="742152.A0A2H3J9C1"/>
    <dbReference type="OMA" id="RNIHASC"/>
    <dbReference type="OrthoDB" id="2803467at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47501:SF5">
        <property type="entry name" value="HAT C-TERMINAL DIMERISATION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47501">
        <property type="entry name" value="TRANSPOSASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH34258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="456" mass="50429" checksum="14541B73D10C6295" modified="2018-01-31" version="1">MSVTKSWQRLSELQSLIDSLPSSLPHGTSEGPIARYFSDLSVDPDEGPYYSVDWAWTHVFQVSEHSKIKLVCRGEYGLQLIHNFLAYFITVPGIEKDNGLQLLEDRIGSLIDLITHVKAAFTAAQQASIDSDAAFATADAATSKSHVAVNNTVPSKKQLMDSTAKKPSIVGKILNKPSEPHVIFNSSTDNESDVPEVNKKAGRCPIKAEWALAQFEPLAATHKSQPIWKWRCNWTFRTSPQTPKCREYAQETLKAPVSSNFISHLEKCEGLPADQTFAAWSSRKNGQLGDGLITEMHSQGGRQAQTRFMLEFTKQGADNPEKQLNKVMQENPSKIAVASDLWTSKNSVYAFAGTVAFWIDDNWDLIEHVLELLPLDGDHSGAASAKLIFNALHRRKVTDKLRNIHASCILVASTADNAASNSTMNHTLSTMIQKKHGILLDPQEIQSRPSSTPRPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J9L3</accession>
    <name>A0A2H3J9L3_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Mitochondrial carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WOLCODRAFT_140476</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467876">
        <property type="protein sequence ID" value="PCH36483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J9L3"/>
    <dbReference type="STRING" id="742152.A0A2H3J9L3"/>
    <dbReference type="OMA" id="CAGMSFW"/>
    <dbReference type="OrthoDB" id="14252at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF10">
        <property type="entry name" value="SLC (SOLUTE CARRIER) HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="82"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="186"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PCH36483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="277" mass="29875" checksum="A355A5511BEBD0B2" modified="2018-01-31" version="1">MAALAVGFPFDTVKVRFQDAASARTYASTFHALFTILREERITGLYRGISSPLLTAAPLNGVVFSSYRWLLNIGASNDDLPPSLLRVTLTGAGSGIIATVITTPTELIKIRQQSLQSALAGSSSLQPPITARVVATDIFKQHGLQGLYRGITATALRDIGYGTYFFAYEATVRYWPRAPGSGARAPPWQATLVAGALAGIAGWVVTFPFDVVKTRVQNTHSAARDNLYRSTRSTIVASYRAEGPSVFFRGLAPTLIRAIPVNMVTFTTFEAIVHAFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JA90</accession>
    <name>A0A2H3JA90_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_156360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="PCH35659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JA90"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH35659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="223" mass="24885" checksum="C3A172ED6867C5CB" modified="2018-01-31" version="1">MPSPQPTPPCTVSPTPTHHSIDSITTNDFLLDPPLYDHPIGPAEELLYDHPAGPMEGPIYDQPGGPMEGPIYPYPAGPKYWDNPLYPPPHPLIPTHSITIQVNNVLQCVSPNCEPYNAHLLSMNWYEALTNTSFFYHLHHLNICETTHIAFSNFTWINDWSTKIHSSINISFCDDNSNVITNQVIESIEILQACTRKCDVFNNQISYKTVNDTPVLAASSSAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JAL3</accession>
    <name>A0A2H3JAL3_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Post-GPI attachment to proteins factor 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WOLCODRAFT_97447</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
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            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the lipid remodeling steps of GPI-anchor maturation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Endoplasmic reticulum membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PGAP3 family.</text>
    </comment>
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        <property type="protein sequence ID" value="PCH38635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JAL3"/>
    <dbReference type="STRING" id="742152.A0A2H3JAL3"/>
    <dbReference type="OMA" id="DFMIEDC"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007217">
        <property type="entry name" value="Per1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13148">
        <property type="entry name" value="PER1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13148:SF0">
        <property type="entry name" value="POST-GPI ATTACHMENT TO PROTEINS FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04080">
        <property type="entry name" value="Per1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2 7" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016479346" description="Post-GPI attachment to proteins factor 3" evidence="7">
        <location>
            <begin position="22"/>
            <end position="343"/>
        </location>
    </feature>
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        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="189"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="235"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="279"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="313"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PCH38635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="343" mass="39409" checksum="0920D0604CE03CFE" modified="2018-01-31" version="1">MRSDTRLLAWITLALVAYAYASSGDRAENYQRCVADCESLVCRDSTWANSLSYALRLTRWTCTDDCKYGCMHAITDHAVQNALPIQQYHGKWPFWRLAGMQEPASVFFSLLNLLCHTRGARRVRRTVPDSHPMKGYYLRFAYVSVNAWVWSAVFHTRDLPTTEKLDYFSAALAILYALYYTAIRLFHLYPAPRARLTSSISPAIRSRTCIAWTALCALAYIAHVSYLTLLPRFDYTYNMAFNLAVGMTHNLLWLAYSFPAFIPLFRRFPARPRSYRPPYASGAAGFVLLTTLATTLELFDFPPWGRVIDAHSLWHLATVPIAVFWYEFLILDALDEGWREQKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JAS2</accession>
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        <recommendedName>
            <fullName evidence="3">LCCL domain-containing protein</fullName>
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        <lineage>
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            <taxon>Phaeolaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
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                <person name="Lucas S."/>
                <person name="Lundell T."/>
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                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
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                <person name="Stenlid J."/>
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                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467831">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR053037">
        <property type="entry name" value="Pericyclase_pydY-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38115">
        <property type="entry name" value="LIPOCALIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38115:SF1">
        <property type="entry name" value="LIPOCALIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH33754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="186" mass="21171" checksum="F35E7156D6031B0D" modified="2018-01-31" version="1">MAVPPNMTVLNTSGKYFMNKSLSDDIDEILRLQGVGWVKRKIIRVGTLYLNINHYTDDASIEHIDIVQSLSGLSTSSEDRILDWVERPHEDDVFGDVLNINKRVAAGEVEGDWLKMGWTEDTLEKGLVYTRARSDTAKSGTTWLAVQTWGFEVINGERRYVRHVDFTGPKGEKVHARLVYDYQGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
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    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    </protein>
    <gene>
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    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467865">
        <property type="protein sequence ID" value="PCH35929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JB05"/>
    <dbReference type="STRING" id="742152.A0A2H3JB05"/>
    <dbReference type="OMA" id="WIRRKDN"/>
    <dbReference type="OrthoDB" id="10256743at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH35929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="321" mass="33951" checksum="E0E63C99658B1044" modified="2018-01-31" version="1">MDAAATAASVQPSAPAPAAPTDGPAPMSFPAILRTPGLSDRFAHLRPAVGNKVAVPAVPKRNGRDDKEGKRWVRRKESDVGAVPRRNGVETPLRRSQFVGNAHIVPPTKRDYALPLPAKTPTFPVLLLPYIPRSVPIPPSAPPTREPSSAAAGPRTEALVRDVESALLAWLADDVLLVPDDAALLAFPGAPLGETGVVGEVQRAPLGLVWSVHDDGFARYVVHCGARFHGVARMIRCTASRTSSARTSPGIRAPPPRSAPRRARARHVASDAYLSSDAGSERDPDETLRLQAIAEASAPRSPALAARVLSDDEWSVVDADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JB76</accession>
    <name>A0A2H3JB76_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">cysteine synthase</fullName>
            <ecNumber evidence="4">2.5.1.47</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Cysteine synthase-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">WOLCODRAFT_134040</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>O-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate</text>
            <dbReference type="Rhea" id="RHEA:14829"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:58340"/>
            <dbReference type="EC" id="2.5.1.47"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cysteine synthase/cystathionine beta-synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.47" evidence="4"/>
    <dbReference type="EMBL" id="KB467865">
        <property type="protein sequence ID" value="PCH35999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JB76"/>
    <dbReference type="STRING" id="742152.A0A2H3JB76"/>
    <dbReference type="OMA" id="WMADYGF"/>
    <dbReference type="OrthoDB" id="10259545at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01561">
        <property type="entry name" value="CBS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000016">
        <property type="entry name" value="Cysteine synthase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000096">
        <property type="entry name" value="Related to cysteine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050214">
        <property type="entry name" value="Cys_Synth/Cystath_Beta-Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10314">
        <property type="entry name" value="CYSTATHIONINE BETA-SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="13" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="12 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="9" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="17">
        <location>
            <begin position="70"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="17">
        <location>
            <begin position="250"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00078545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PCH35999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="473" mass="51774" checksum="FF1745F86078E3A3" modified="2018-01-31" version="1">MDASWLPSWIQIPSRTTARHIIYGILIGLSLSLTSTSFALYYQERKRERVARQFEARPIELRSDEVTKGVTGLIGNTPLVRINSLSDALGIEILGKAEFLNPGGSVKDRVALRMIDDAERQGLLHPHTGSRIFEGTVGSTGISIATVAKARGYLATIIMPDDVAQEKVQALQALGAQVERVRPASIVDKKQFVNLARERAKNFGLEDSFSNQHLTVPRGHLLPSPSSSVLVSTAATDALGEEGTVTAPHEEEALRTKPRGFFADQFENKSNYDAHFEGTGPEIWRQTNGRLDAFVSGAGTGGTIAGIGRFLKSMDEDVKVVLSDPDGSGLYNKIKHGVMFDRREAEGTKRRHQVDTVVEGIGINRLTKNFQLALPILDDAYRISDAEAVSMSRYLVQRDGLFIGSSSACNLVACVKLAKKMGWKEGQTVVTILCDSGSRHYSKPRNDDYLHKANIPIDPHIIEDLLSQPGTKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JB92</accession>
    <name>A0A2H3JB92_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pre-mRNA-splicing factor CWC26</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_141283</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CWC26 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467998">
        <property type="protein sequence ID" value="PCH39456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JB92"/>
    <dbReference type="STRING" id="742152.A0A2H3JB92"/>
    <dbReference type="OMA" id="NGFENRW"/>
    <dbReference type="OrthoDB" id="6022at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070274">
        <property type="term" value="C:RES complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018609">
        <property type="entry name" value="Bud13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051112">
        <property type="entry name" value="CWC26_splicing_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31809">
        <property type="entry name" value="BUD13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31809:SF0">
        <property type="entry name" value="BUD13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09736">
        <property type="entry name" value="Bud13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="171"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="73"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH39456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="250" mass="28853" checksum="7FA12F9C60FEC4A2" modified="2018-01-31" version="1">MAEAVIASDRGFKKRQRTDESSGWATVRESERASPSPAADEQPQVVDMKEEESGSSAPFKGGLLTSAQLKKTLPKEKAMKKSKEEEELERAAAQETVYRDASGRRIDTAAERAEAARKKREREEQEARKMEWGKGLVQREEEEKRKQEEVAMREHAFARTKDDVEMNEELKAQERWDDPAAAFLTKKRTKGPRRPEYTGPPPPPNRFGIKPGYRWDGVDRGNGFEKKYFQRQNDKRRRGLESYEWSVDDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JBM3</accession>
    <name>A0A2H3JBM3_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UBR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WOLCODRAFT_146581</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467909">
        <property type="protein sequence ID" value="PCH37213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JBM3"/>
    <dbReference type="STRING" id="742152.A0A2H3JBM3"/>
    <dbReference type="OMA" id="GAMVYNH"/>
    <dbReference type="OrthoDB" id="5795902at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19677">
        <property type="entry name" value="UBR-box_UBR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040204">
        <property type="entry name" value="UBR7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047506">
        <property type="entry name" value="UBR7-like_UBR-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003126">
        <property type="entry name" value="Znf_UBR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13513">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13513:SF9">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02207">
        <property type="entry name" value="zf-UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00396">
        <property type="entry name" value="ZnF_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51157">
        <property type="entry name" value="ZF_UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBR-type" evidence="6">
        <location>
            <begin position="28"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="UBR-type" evidence="4">
        <location>
            <begin position="28"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="162"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="254"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="271"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PCH37213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="440" mass="47671" checksum="ED79D24A4DFF95D4" modified="2018-01-31" version="1">MSQTIASILASQHNLIQAAAEALPHQFSQCTYLLGPVRQAVYLCRTCAEPRGICSACSIACHPDHEQLELFPKRAFRCDCPTAALAHPCTLHQPSSSSALTAMTSAGLMKERANAENAYGQNFRGLFCRCARPYDAQQERETMIQCLACEDWFHESCLNLRERPSSREPTPDPAEGAEGGADDAASEASSSGLPPPLLSAADYDALVCVACVRSIPTLRRYAGTHGALMVVRGGPEESWRVIGREADTLDVEVQLDAPENESTTGDKRALSPDSADAPAAKKARVSPEPTPSRPCLAPLVNPLAQRILDGSASGPEAAVSQSDGEPSIQGAGDVFLTDGWQERWCRCDSCLPSLQSRPYLLEEEETYEPPEDPDSGLNLEELGLRALSRLPHDQAIDGIRAFNALRDDLMSHLRPFAQEGREVTEADIRAFFDARTQANP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JCI1</accession>
    <name>A0A2H3JCI1_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_145799</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467843">
        <property type="protein sequence ID" value="PCH35388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JCI1"/>
    <dbReference type="STRING" id="742152.A0A2H3JCI1"/>
    <dbReference type="OMA" id="PDIPHIV"/>
    <dbReference type="OrthoDB" id="3265311at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="458"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH35388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="541" mass="58547" checksum="C49082EEBFD9031C" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JCX8</accession>
    <name>A0A2H3JCX8_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Serine/threonine-protein kinase RIO1</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Serine/threonine-protein kinase rio1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">WOLCODRAFT_162056</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="KB468053">
        <property type="protein sequence ID" value="PCH40056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JCX8"/>
    <dbReference type="STRING" id="742152.A0A2H3JCX8"/>
    <dbReference type="OMA" id="DKDGWAS"/>
    <dbReference type="OrthoDB" id="205248at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05147">
        <property type="entry name" value="RIO1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000148">
        <property type="entry name" value="Serine/threonine-protein kinase RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051272">
        <property type="entry name" value="RIO-type_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018934">
        <property type="entry name" value="RIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000687">
        <property type="entry name" value="RIO_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018935">
        <property type="entry name" value="RIO_kinase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45723">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01163">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00090">
        <property type="entry name" value="RIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01245">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RIO kinase" evidence="20">
        <location>
            <begin position="200"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="53"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="117"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="388"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="491"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="524"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="601"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="117"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="147"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="422"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="498"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="532"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="601"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="637"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="663"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="19">
        <location>
            <begin position="691"/>
            <end position="713"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00068838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="PCH40056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="713" mass="79644" checksum="46E47489ECDE530E" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JCY2</accession>
    <name>A0A2H3JCY2_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Amidohydrolase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WOLCODRAFT_34004</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD-104</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KB468053">
        <property type="protein sequence ID" value="PCH40112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JCY2"/>
    <dbReference type="STRING" id="742152.A0A2H3JCY2"/>
    <dbReference type="OrthoDB" id="194468at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008892">
        <property type="term" value="F:guanine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046098">
        <property type="term" value="P:guanine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Urease, subunit C, domain 1"/>
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    </dbReference>
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    </dbReference>
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    <dbReference type="PANTHER" id="PTHR11271">
        <property type="entry name" value="GUANINE DEAMINASE"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR11271:SF6">
        <property type="entry name" value="GUANINE DEAMINASE"/>
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        <property type="entry name" value="Metallo-dependent hydrolases"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="5">
        <location>
            <begin position="62"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH40112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="458" mass="50524" checksum="F736B18A9C51C888" modified="2018-01-31" version="1" fragment="single">MLIIGDFVHCPTPGEIEILRDHLIGMHNAGFINHVAPVHLEESRKILDQAREHPISVEQGSFITPTFCDLHLHAPQFLYQGTGLHLPLMKWLDEYAFKAEERLDADHTLAEKVYRQLAVRLVENGTGAVLLFGTIKSETNLILARVMQEAGIRAFVGKLSMDISSRPSYVEASADDSLAAARSFVAQCRALTAHLPEHERLVEPVLTPRFVPTCSDKLLDGLGELAKEQYLRVQSHMAEAHDQVEWVRRERGTDDMAIFKRYNLLTPRAVLAHCTFLEPDALTQLAAAGPAIAHCPLSNAYFSARPLRLREALNAGVRVGLGSDIAGGYDASIAGGMRQAVAVSRMREGARIVGGDELAKGEKLDVDWKEALYLATRGGAIALGLAEWSGTFVVGAPFDAQCIRLFDRAGGIGVGPLDFLDFFDDDARGELTLEMLEKWWCIGDHRNRANMWVQGKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JE65</accession>
    <name>A0A2H3JE65_WOLCO</name>
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    <gene>
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        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD-104</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <location>
            <begin position="12"/>
            <end position="116"/>
        </location>
    </feature>
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        <location>
            <begin position="100"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-AMP-histidine intermediate" evidence="1">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH40496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="142" mass="15705" checksum="27632B53C8BB9A11" modified="2018-01-31" version="1">MASGAKTLASCVFCKIIKGEIPSFKLVETDLSYSFLDINPLAKGHALVIPKYHGEKLHDVPDEYLVDTLKVGKKIAVASGLENYNILQNNGRIAHQEVDHVHFHVIPKPAATDTEGLVIGWPQQKVEMDELKALHEELLAKL</sequence>
</entry>
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    <accession>A0A2H3JE75</accession>
    <name>A0A2H3JE75_WOLCO</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">WOLCODRAFT_150558</name>
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        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468053">
        <property type="protein sequence ID" value="PCH40506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JE75"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013850483" evidence="1">
        <location>
            <begin position="21"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH40506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="111" mass="11774" checksum="39A1A4A94D817812" modified="2018-01-31" version="1">MLLAVIILFLGLGMLTQLLTKGPMQCWLPTSGSSGGDCRNMWVVWGKWGFEDWGIMLAQIGTACLEVAMTARLGNKVGSMSAGTMQHVGGLPVASLCVGVPAPPYHLPKML</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JF86</accession>
    <name>A0A2H3JF86_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Actin-related protein 2/3 complex subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WOLCODRAFT_99465</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the Arp2/3 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
            <location evidence="1 6">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ARPC3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH40876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JF86"/>
    <dbReference type="STRING" id="742152.A0A2H3JF86"/>
    <dbReference type="OMA" id="TPSKWWL"/>
    <dbReference type="OrthoDB" id="200404at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Actin-related protein 2/3 complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007204">
        <property type="entry name" value="ARPC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036753">
        <property type="entry name" value="ARPC3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12391">
        <property type="entry name" value="ARP2/3 COMPLEX 21 KD SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P21-Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Arp2/3 complex 21 kDa subunit ARPC3"/>
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    </dbReference>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="180" mass="20105" checksum="652AB63F6C4B1DED" modified="2018-01-31" version="1">MPAYHSSFNEEPDIRQVGNMSILPIKSKYRGPAPTADPAQADCIDEALDLFRANSLFRNFEIKGGADRLLIVLILFVSDCLAKIGSARSVPSQIEATKMLNTLAVDNFPVPGDANFSLNAHYAPPASRIDAEQLRQYLTQVRQELAARLIERLYADGTGKPSKWWMSFQKRRFMSRSLGT</sequence>
</entry>
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    <accession>A0A2H3JFB9</accession>
    <name>A0A2H3JFB9_WOLCO</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_150931</name>
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        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
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                <person name="Stenlid J."/>
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                <person name="Martin F."/>
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            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH40906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="250" mass="26919" checksum="457EDB9B72367E5D" modified="2018-01-31" version="1">MHGGRGNESEEGAQRCELEPEVRCFNIATTSSPSSWENEIVAELPCQRVARRSCRPLLAALSSHHHPLHTPTCSPSARAPPRPLPAQRTGHAQRHALPTPRPFPASSLSAIWADLAMREHHDGTNNGPHVPELCGCTPNKVTSVTKTGQLARRSDAQFRRYLQKAPCSLCPHVPAATVIGPAAHSVLRLRANPSPRAPIGVTNIHADVSTDRAAVRTLACTTDNTQCAACAATAVAWCRASDRVRTVYQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JFD2</accession>
    <name>A0A2H3JFD2_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ras GEF</fullName>
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    </protein>
    <gene>
        <name evidence="9" type="ORF">WOLCODRAFT_131313</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
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                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11883">
        <property type="entry name" value="SH3_Sdc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019804">
        <property type="entry name" value="Ras_G-nucl-exch_fac_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
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        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF354">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="RasGEFN"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00720">
        <property type="entry name" value="RASGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="6">
        <location>
            <begin position="87"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="8">
        <location>
            <begin position="849"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="7">
        <location>
            <begin position="1027"/>
            <end position="1265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="190"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="343"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="468"/>
            <end position="504"/>
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    <feature type="region of interest" description="Disordered" evidence="5">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
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</entry>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
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                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
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                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
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                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
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            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Spatafora J.W."/>
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            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00020833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PCH38623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="232" mass="23912" checksum="05658913FF727184" modified="2018-01-31" version="1">MVSITAIKKGKAKAAASKAKSAKASSRAVAKAPAAHPSWKDMVKECIQDHKEEARHGVSRATIKKYIAKKYKVELDNANASMLNRAIAHGAKTGLFALPKGPSGKVKLAPKIKPAPANENVQPAAAPKEKEKKAPAAKPAKVPAKKAAPAKPSTKPATVRKTTKPPPSPKKVSSARANSKKTAAKAAAAKAITKSKVAKPAPKAGAAKPASAKAKAAPKPRARAKKEKPAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JGW7</accession>
    <name>A0A2H3JGW7_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HIT-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_130625</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH38019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JGW7"/>
    <dbReference type="STRING" id="742152.A0A2H3JGW7"/>
    <dbReference type="OMA" id="IHDMFPK"/>
    <dbReference type="OrthoDB" id="3512845at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033699">
        <property type="term" value="F:DNA 5'-adenosine monophosphate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990165">
        <property type="term" value="F:single-strand break-containing DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000012">
        <property type="term" value="P:single strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032566">
        <property type="entry name" value="Znf-C2HE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12486:SF4">
        <property type="entry name" value="APRATAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12486">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11969">
        <property type="entry name" value="DcpS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16278">
        <property type="entry name" value="zf-C2HE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aprataxin C2HE/C2H2/C2HC zinc finger" evidence="2">
        <location>
            <begin position="146"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH38019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="268" mass="31464" checksum="F725758F2D0B920C" modified="2018-01-31" version="1">MDEEKILRKYARKADPQSLPPTIRFEYDEHTLTVYDAYPKSVFHFLILPRIVPPLTAGRLASLRTLLQGDKAQAKEVLDRLDAAAKIVREQIEAEMLNRFGYKWSIWTGFHAVQSMEHVHLHVISSDLCSPSMKNKKHYNSFHPEHGFFLPLEEILSWPEAEPSWYATMSELRPSQYEPFLKESLSCWRCYKEFKNMPLLKEHLQEEWDAEAKRERARLERKQKLEQDRLKKADRGESPSAKRQRESSPSDPEPKRQRADSPSQSTQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JH42</accession>
    <name>A0A2H3JH42_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Clavaminate synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_151240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH41201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JH42"/>
    <dbReference type="STRING" id="742152.A0A2H3JH42"/>
    <dbReference type="OMA" id="YWHDMEF"/>
    <dbReference type="OrthoDB" id="424465at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461:SF99">
        <property type="entry name" value="BIFUNCTIONAL PEPTIDASE AND (3S)-LYSYL HYDROXYLASE JMJD7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="1">
        <location>
            <begin position="164"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH41201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="353" mass="39609" checksum="C4B00E5BF9664688" modified="2018-01-31" version="1">MAQNTLTPASTQEDTLKWVANEYYDLNGVHYDVLRDPPTPLEFLRLVRIARPVLMKHSEAPDAMSRWSNEYLTDRMGDSPISIAVTPNGRADAITVGRDGRQYFAEPHVEKMTMRAFLDKITAELCGMNAEDNGEVLYLQSQNGNLYTAQYFDLSAEAETSEYGPLREDVPCENLWCSDALDKSPDAVNLWIGNSASVTSIHSDPYENIYTVVRGAKHFTLFPPTEGWCLSERTYPHASYVRSQATGQLELVPSPPGTPGVRWSSVLDPTNSSALPAEVHPISITVRAGETLYLPAGWWHYVRQSEVTIAVNYWYDMESRGMAWVWLNFLRGLREPPPGNEEGSGRDPDHTFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JHA9</accession>
    <name>A0A2H3JHA9_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">60S ribosomal protein L2/L8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WOLCODRAFT_89374</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6 7">MD-104</strain>
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        <text evidence="1">Belongs to the universal ribosomal protein uL2 family.</text>
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        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
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        <property type="entry name" value="PRK09612.1"/>
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    </dbReference>
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        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL2"/>
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            <dbReference type="ARBA" id="ARBA00023274"/>
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    </evidence>
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            <dbReference type="EMBL" id="PCH41562.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="254" mass="27626" checksum="289F622366FC7E2D" modified="2018-01-31" version="1">MGRVVRAQRRSHAIFKAHTHHNKAPAKFRVLDYAERNGYIKGIVKEIIHDAGRGAPLARVVFRDPYRYKLRKETFIATEGLHTGAFVYCGKRAQLTIGNVLPVSQCPEGTIVCNVEEKSGDRGALARTSGNYATVIGQSPDENKTRVRLPSGAKKTISGSCRATIGIVAGGGRIDKPLLKAGRAFHKYKAKRYSWPRTRGVAMNPVDHPHGGGNHQHIGKASTIARSAVPGQKVGLIAARRTGLLRGTIKVKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JHB6</accession>
    <name>A0A2H3JHB6_WOLCO</name>
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        <recommendedName>
            <fullName evidence="6">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WOLCODRAFT_161343</name>
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    <organism evidence="7 8">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD-104</strain>
        </source>
    </reference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Rabenosyn, Rab binding domain"/>
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        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
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    </dbReference>
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        <property type="entry name" value="Rab4/Rab5_effector"/>
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        <property type="entry name" value="Rbsn_Rab-bd"/>
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        <property type="entry name" value="Rbsn_Rab-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
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        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
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    <dbReference type="PANTHER" id="PTHR13510">
        <property type="entry name" value="FYVE-FINGER-CONTAINING RAB5 EFFECTOR PROTEIN RABENOSYN-5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RABENOSYN-5"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="FYVE"/>
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        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Rabenosyn-5 Rab-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
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    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="6">
        <location>
            <begin position="516"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="733"/>
            <end position="758"/>
        </location>
    </feature>
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        <location>
            <begin position="20"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
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            <begin position="46"/>
            <end position="60"/>
        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
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            <end position="228"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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            <begin position="372"/>
            <end position="397"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PCH38159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="832" mass="90709" checksum="413CE13BC6EA07A2" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JHB8</accession>
    <name>A0A2H3JHB8_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_163206</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">MD-104</strain>
        </source>
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        </location>
    </feature>
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    </feature>
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            <begin position="405"/>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH41566.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="416" mass="45623" checksum="30D249676130D2A0" modified="2018-01-31" version="1">MPGTDADTGKMSKRIHRCVARLAGFFQSVFSDKCATRLFGIGSGSAGTEKPVRPHHPGHTVSAPEVKRLRIQTDAISHPMDAELIRIKSSTAALPSQHDGLQAPRRAHKFTKEPARRVDDPYIARTEGPHVVRFPRGAGSPTSTDSRRSPCRTPYASSSNVTSASSLALPRSLSEHDLSYRALKKHPEFDFEIRAVPLPPIPNTKEWRRIKRELGAEHAKRAKAPDWTEAEAESECSDGPYPVDVVAPADWQQESARRAPALHQDTRVTSSGSSSIPRRSANGVATATRQQESVMRPLGPAQRGTQRTFSSTSGLSRHTETYHTDFRTREATEASRSLAIPSEVSSVESMSQAEPVASQRYAMYLELDGISSFTGPSSMSRAFNVDMQHVAFDGYNHAQKMYPQPSRSAGRSASPR</sequence>
</entry>
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    <accession>A0A2H3JI51</accession>
    <name>A0A2H3JI51_WOLCO</name>
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        <submittedName>
            <fullName evidence="7">Nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="7" type="ORF">WOLCODRAFT_101255</name>
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        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
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                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1221748"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="entry name" value="CbxX/CfxQ_RuBisCO_ESX"/>
    </dbReference>
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        <property type="entry name" value="DNA2/NAM7-like_C"/>
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    </dbReference>
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        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43392">
        <property type="entry name" value="AAA-TYPE ATPASE FAMILY PROTEIN / ANKYRIN REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43392:SF2">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="AAA_12"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </feature>
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    </feature>
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            <end position="1257"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PCH41870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="2333" mass="260281" checksum="38540EB00E256EE1" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JJ29</accession>
    <name>A0A2H3JJ29_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Acetate kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_152218</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
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    <dbReference type="SUPFAM" id="SSF53067">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH42182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
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                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
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                <person name="Hori C."/>
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                <person name="Sabat G."/>
                <person name="Salamov A."/>
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                <person name="Stenlid J."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
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            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH42376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="110" mass="11798" checksum="1CB34094F3D63952" modified="2018-01-31" version="1">MRPAAPPASHATQYPPHVSPPGIPQARVKENVRPLFPQAAPQALQPAFPARQVAGPPALPVPVVRLSQQPNLMARILHGPSPLSRQPSNVELHQLGPVRTAKARRRAGPH</sequence>
</entry>
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        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
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        <lineage>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
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                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
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                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
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                <person name="Stenlid J."/>
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                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
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                <person name="Martin F."/>
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            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="16 17">MD-104</strain>
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        <text evidence="12 13">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
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    <comment type="subunit">
        <text evidence="4 13">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the tubulin family.</text>
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        <property type="entry name" value="Tub_FtsZ_C"/>
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        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
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        <property type="entry name" value="Tubulin_C"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="10 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 13" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="14">
        <location>
            <begin position="48"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="15">
        <location>
            <begin position="251"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="466" mass="51911" checksum="3426B58E292E373A" modified="2018-01-31" version="1">MPREIINVQTGQAGNQIGESFWEMLLAEHGLDNEGFYKGNDPLQLPMVDVFFSEIDQPNGPSKYVPRSVQIDLEQGVCARIRSGKMGALFRPDTFITAESGAGNNWAKGFYTEGAELVDNIMDIIRRQAESCDAMQGFQLIHSLGGGTGAGLGTLLLSKFREEYPDRMLSTFSILPSPKVSETVVEPYNALLAIHQLVENSDLTMVVDNEALYDISVQTLKVKAPTFTDLNVIVSQVMCGVSTSLRFPGQLNGDLRKLGLNLIPFPRLHFLMPSYAPLHDPKAKAFARLSVPELTSALFDRRSLLVACDPRYGRYLTAATIFRGKISSREAEHSVLELQRKNSNQFVEWIPDNVSVALCSVPPVGQTQAATCLANSTAVQELFQRTLNQFGAMYKRGAFLHWYTGEGMDAMEFSEAESNAHDIVSEYQQYQEATLEADEQDEYYEHEEYAEDLNAHQEEEFTDGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JL12</accession>
    <name>A0A2H3JL12_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WOLCODRAFT_136925</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Phaeolaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD-104</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468053">
        <property type="protein sequence ID" value="PCH40543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JL12"/>
    <dbReference type="STRING" id="742152.A0A2H3JL12"/>
    <dbReference type="OMA" id="RNEINDM"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PCH40543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="248" mass="27379" checksum="3561A9E29754A562" modified="2018-01-31" version="1">MSVLIRENMLASLEDKLPEDEVLAQISTLVFAATDTSSNTLSRILELLAHHPDMQEKLREELLTAGAAEGIPYDQLNQLPYLDAVVRETLRRYPPLTLLSRVPKQDVVLPLHKPVRGVDGTLITELPLKEGTEIALGIQGINTLEELWGEDALEWNPQRWLSPLPKAVSEARIPGVYANMLTFLGGPKGCIGFKFAETGIKVTLAVLLSHFTFAPTKGQIVWNLAGIYYPTVEPDRNNPQLPLVVSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JLS2</accession>
    <name>A0A2H3JLS2_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_74244</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468135">
        <property type="protein sequence ID" value="PCH43152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JLS2"/>
    <dbReference type="STRING" id="742152.A0A2H3JLS2"/>
    <dbReference type="OMA" id="RCHWDID"/>
    <dbReference type="OrthoDB" id="3222669at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="173"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="218"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="278"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="564"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="624"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="471"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="565"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="587"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="652"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="668"/>
            <end position="678"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH43152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="678" mass="74641" checksum="1200B03C3212E023" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JLZ7</accession>
    <name>A0A2H3JLZ7_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WOLCODRAFT_138251</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468135">
        <property type="protein sequence ID" value="PCH43222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JLZ7"/>
    <dbReference type="STRING" id="742152.A0A2H3JLZ7"/>
    <dbReference type="OMA" id="IWRFPVA"/>
    <dbReference type="OrthoDB" id="2544694at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF78">
        <property type="entry name" value="MONOSACCHARIDE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02110)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="9"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="368"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="391"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="424"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="464"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="492"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="13"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PCH43222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="573" mass="64423" checksum="45F108894EE3C5F9" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JM19</accession>
    <name>A0A2H3JM19_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF1000-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_136432</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PITHD1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH38768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JM19"/>
    <dbReference type="STRING" id="742152.A0A2H3JM19"/>
    <dbReference type="OMA" id="PLAGTNM"/>
    <dbReference type="OrthoDB" id="10263751at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.470">
        <property type="entry name" value="PITH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045099">
        <property type="entry name" value="PITH1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010400">
        <property type="entry name" value="PITH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037047">
        <property type="entry name" value="PITH_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12175">
        <property type="entry name" value="AD039 HT014 THIOREDOXIN FAMILY TRP26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12175:SF5">
        <property type="entry name" value="OS03G0795500 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06201">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51532">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PITH" evidence="2">
        <location>
            <begin position="1"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH38768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="173" mass="19574" checksum="1B3E88EA90BDEE9F" modified="2018-01-31" version="1">MSEEIEPSLLEHLDILQLTCLNEEGDHTLKSIVSARSRNTSGSYLLSDVDEQLLLNITFNQTVRIRSILIKSSNVTQAPRKIRLLVNRISLGFDDIEDGEIAQEFELTEEQVREGKRIPLRYVRFQGVNSLHIFVESNHGDEDQTRVDAIDIFGVPVAGTRDLSGLRAVEEEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JMT1</accession>
    <name>A0A2H3JMT1_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Small oligopeptide transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WOLCODRAFT_164477</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468146">
        <property type="protein sequence ID" value="PCH43490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JMT1"/>
    <dbReference type="OMA" id="ACSFLWY"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00727">
        <property type="entry name" value="ISP4_OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="389"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="442"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="468"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="552"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="587"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="619"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="668"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="697"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PCH43490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="767" mass="86621" checksum="F0EA41592621A512" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JMU8</accession>
    <name>A0A2H3JMU8_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">NEDD8-activating enzyme E1 catalytic subunit</fullName>
            <ecNumber evidence="8 11">6.2.1.64</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WOLCODRAFT_135960</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalytic subunit of the dimeric E1 enzyme, which activates NEDD8.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>ATP + [NEDD8 protein] + [E1 NEDD8-activating enzyme]-L-cysteine = AMP + diphosphate + [E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine.</text>
            <dbReference type="EC" id="6.2.1.64"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Protein modification; protein neddylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ubiquitin-activating E1 family. UBA3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.64" evidence="8 11"/>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH37964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JMU8"/>
    <dbReference type="STRING" id="742152.A0A2H3JMU8"/>
    <dbReference type="OMA" id="PYLENYM"/>
    <dbReference type="OrthoDB" id="10255449at2759"/>
    <dbReference type="UniPathway" id="UPA00885"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019781">
        <property type="term" value="F:NEDD8 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01488">
        <property type="entry name" value="Uba3_RUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.520:FF:000001">
        <property type="entry name" value="NEDD8-activating enzyme E1 catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.20:FF:000003">
        <property type="entry name" value="Ubiquitin-activating enzyme E1 C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.520">
        <property type="entry name" value="Ubiquitin activating enzymes (Uba3). Chain: B, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.20">
        <property type="entry name" value="Ubiquitin-like 2 activating enzyme e1b. Chain: B, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014929">
        <property type="entry name" value="E2-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023318">
        <property type="entry name" value="Ub_act_enz_dom_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030468">
        <property type="entry name" value="Uba3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033127">
        <property type="entry name" value="UBQ-activ_enz_E1_Cys_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF6">
        <property type="entry name" value="NEDD8-ACTIVATING ENZYME E1 CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08825">
        <property type="entry name" value="E2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01181">
        <property type="entry name" value="E2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00865">
        <property type="entry name" value="UBIQUITIN_ACTIVAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="E2 binding" evidence="12">
        <location>
            <begin position="349"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="10">
        <location>
            <position position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PCH37964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="432" mass="48237" checksum="33FFF062B24A0D3F" modified="2018-01-31" version="1">MATEVLTNGDAQAADWPDRYYHVDQILDRPGPRTDPSFMAGDGVKDFLRSQCKILVIGAGGLGCEILANLALSGFKDIHVIDMDTIDISNLNRQFLFRPKDVGKPKAIVAAEFIMNRVPGVKVTPYYGKIQDKDDDYYMQFNLVICGLDSVEARRWINATLVNLVDPENPESLKPLIDGGTEGFKGQARVILPTITSCYECSLDMLNKPTAFPICTIANTPRLPEHCIEWASVLEWPRVFQDKKLDTDDPEHIGWLYKTALARAKEFKIEGVTWSLTQGVVKNIIPAIASTNAIIAASCCNEAFKIATSSAAYLNNYFMLIGTDGVYSYTFEHEKREDCPVCGGEALDISISRDWTVDRLIEMLIEKQDIQIKKPSLSTATKQIYFQAPPQLEELTRPNLEKKVSELVEDGDHITVTASSLPFNLTLRVKYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JMZ0</accession>
    <name>A0A2H3JMZ0_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">WOLCODRAFT_138265</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">MD-104</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468135">
        <property type="protein sequence ID" value="PCH43261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JMZ0"/>
    <dbReference type="STRING" id="742152.A0A2H3JMZ0"/>
    <dbReference type="OMA" id="AVGHRIC"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF5">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013763107" evidence="15">
        <location>
            <begin position="19"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="439"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
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        <source>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
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                <person name="Benoit I."/>
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                <person name="Gaskell J."/>
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                <person name="Gorecki P."/>
                <person name="Heitman J."/>
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                <person name="Kallen N."/>
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    </evidence>
    <sequence length="300" mass="32176" checksum="44902CBE4E7294CE" modified="2018-01-31" version="1">MAPARAYIFIGLNVTRALSIIALLLLFASSIVTLVQDIKAVNVFIADGKTDEVTTGNSTTACTELDYVPNSTVPNQPAGAFWAVLNRLLIMAQSIILILSELGWPAAFFNRYFPVLGDEFGLGALGAIQCLLGAAVLSHHVNEFSLVSAFLLFSIGCLNMVLGLIFRESAKKRRAITSWRETDDVLPRTSLRSGPRPFLTATHTGSSATAWDEKSGSSRSGKGFGRQGEKAALQRGATVTMPPEALPSYAPRPTASPAPTYLSRTVRYKTDEASSSQSKETARPESVLSYTDGNETPNAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JNY7</accession>
    <name>A0A2H3JNY7_WOLCO</name>
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        <recommendedName>
            <fullName evidence="10">B-related factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">WOLCODRAFT_104376</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIB family.</text>
    </comment>
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        <property type="protein sequence ID" value="PCH43896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="742152.A0A2H3JNY7"/>
    <dbReference type="OMA" id="EPPCKVM"/>
    <dbReference type="OrthoDB" id="511529at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000126">
        <property type="term" value="C:transcription factor TFIIIB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000995">
        <property type="term" value="F:RNA polymerase III general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001006">
        <property type="term" value="F:RNA polymerase III type 3 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070897">
        <property type="term" value="P:transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="CYCLIN_TFIIIB90_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20554">
        <property type="entry name" value="CYCLIN_TFIIIB90_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Transcription factor IIIB 90 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000007">
        <property type="entry name" value="Transcription factor IIIB 90 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.650">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011665">
        <property type="entry name" value="BRF1_TBP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013137">
        <property type="entry name" value="Znf_TFIIB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618:SF4">
        <property type="entry name" value="TRANSCRIPTION FACTOR IIIB 90 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07741">
        <property type="entry name" value="BRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08271">
        <property type="entry name" value="Zn_Ribbon_TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00685">
        <property type="entry name" value="TIFACTORIIB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51134">
        <property type="entry name" value="ZF_TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIB-type" evidence="13">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="288"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="508"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="575"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="293"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="379"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="392"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="523"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="537"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="641"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="670"/>
            <end position="680"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PCH43896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="680" mass="75278" checksum="395960CDB3F1D064" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JP05</accession>
    <name>A0A2H3JP05_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_148702</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH37747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH37747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="121" mass="13097" checksum="5378F8970B57517C" modified="2018-01-31" version="1">MFFVFANIWPCPHRHRHPHLAKAPAKAPAKSRAKKSTATPIRKPAMVAFMTHVKSVAPACARALKTILDARAEVLRAKAEVLRLELELRGPDAAAALERELGDVTSLAPQTAVNEDVATTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JQ63</accession>
    <name>A0A2H3JQ63_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Succinyl-CoA:3-ketoacid-coenzyme A transferase</fullName>
            <ecNumber evidence="3">2.8.3.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WOLCODRAFT_96605</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD-104</strain>
        </source>
    </reference>
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        <text evidence="3">Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.</text>
    </comment>
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        <reaction evidence="3">
            <text>a 3-oxo acid + succinyl-CoA = a 3-oxoacyl-CoA + succinate</text>
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            <dbReference type="ChEBI" id="CHEBI:30031"/>
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            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="2.8.3.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Ketone metabolism; succinyl-CoA degradation; acetoacetyl-CoA from succinyl-CoA: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the 3-oxoacid CoA-transferase family.</text>
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    </dbReference>
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        <property type="entry name" value="ACETATE COA-TRANSFERASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="297"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="297"/>
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        </location>
    </feature>
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        <location>
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        <source>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        </lineage>
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    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD-104</strain>
        </source>
    </reference>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0080008">
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0005737">
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        <property type="project" value="TreeGrafter"/>
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        <location>
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        </location>
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        <location>
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        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
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                <person name="Cullen D."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
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    </dbReference>
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    </feature>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="342" mass="38718" checksum="EB812381BA0ED2C5" modified="2018-01-31" version="1">MSVVESSPRLQYFRLGNRVVPRLFNGLWQLSSNAWGSAPTPKVRRQMVQYAEMGYTAFADHYGSSEIIFGQFKQSHPNPENIFGATKWCVFRQTDPTRNVVDTAIQERLDRMQTQQLDLLQFHWQDYSDKGYITALRHLQDLQNEGKIANLGLCNFDAIRTDEICTELGPGSIVSNQVQFSLIDTRPLHGMGDVCERHKVKLLTYGTLCGGFLADQWLNEPEPDLYSGKLTPSQRKYLDMILKAWGDWQLFQTLLATLRDVGDRHGGVSIANVATRWVLDHPCVGAVIIGARLGVSEHRDDNRKVFSFQLTAEDYAAIDEVLDQSNGRRLITTIGDCGAEYR</sequence>
</entry>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
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                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
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                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
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                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
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                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
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                <person name="Lindquist E."/>
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                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
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                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OMA" id="VQHPVKT"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="entry name" value="Velvet domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        </location>
    </feature>
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        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
    <sequence length="131" mass="14642" checksum="9D3B1CB9293B68C3" modified="2018-01-31" version="1" fragment="single">RSYSLEIVQHPVKTAEFGDSTLTRLPLAPPLIARLVEPDNCEAGGIDETELPFLIAQLSLLAGDGSESADFTHGNERQIGQQRLLYGNLVSSPHILRNLQGKQGIYFLFPDVSIRFQGQYRLRVTLLRLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
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                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
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                <person name="Benoit I."/>
                <person name="Boyd A."/>
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                <person name="Ferreira P."/>
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                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
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                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
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                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
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                <person name="Eastwood D.C."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OMA" id="QPRRFRN"/>
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    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
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        </location>
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        </location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH38607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="483" mass="49164" checksum="4522644EDA6D8B0B" modified="2018-01-31" version="1">MSASRVASPASESSSTSYISARSWSTGTSWADSFSGASSDDEVLLSFSDISSPAGGVLSERSALSPSVFSDGGDYILLSRSRSPAYSSAAETTSSAAALDEALAALSSLRLSAAETQAAQQPSSRPSASRFDIGRAATISAGRFALAAPHGVTGAPAARSPAAAQSTGHGSQPDGFDIGRAISVSAVHFAQAAAAHGKAKAHTATQAQGPMGAAQPPSVPTATSFDLQRAIGISAAHFAQAAPHGKANATPVKSPAANKSQKKAKAQQASAPNVATPKKAPAQVAVGAPSKKADKAAKALRKQERLARKAEKAMAEMKKAAAAAASTSSGLGERPIVDDVSEAGDHGEGTVAVSGAYQDARNFITTFLSSPTPKSGAAHLRLAQALIVELGLCPSALSAAPSASFPSLPALPQSLTSARALLKSRIFLNVRDYLEVRAQGLDALRRVMHPSKSALMREIRKGKRVPVKVVKDAGLNVLLITCF</sequence>
</entry>
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    <name>A0A2H3JRU9_WOLCO</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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    <organism evidence="1 2">
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
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                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
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                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
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        </source>
    </evidence>
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        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
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                <person name="Ferreira P."/>
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                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
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                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
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                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
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                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH39147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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        </source>
    </evidence>
    <sequence length="238" mass="25482" checksum="F8735775313BD927" modified="2018-01-31" version="1">MILSSQTLTSTSVHTSAPVSTVAQKVSTSIIPQDPWCATLESQSHVPLTDNLRMIVPIGIVAGMLGAAAIMTCAWFVRRWRRRVREKKNDYESATPAVLLVEGTFPSSVSGGMRKTSITPQPHTGHPEHSEQNVADGHIDEQVDVPPSGMHRNTQPSRPPSYTETAQSAPPPPSPPYSTQSCTRVQTSDIALAYFPGSTSTQSVPRDDIDDRASATPAASKAGGLRDSDQQGLNINLS</sequence>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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                <person name="Ferreira P."/>
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                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
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                <person name="Igarashi K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <feature type="compositionally biased region" description="Gly residues" evidence="1">
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            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH42509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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    </evidence>
    <sequence length="202" mass="21014" checksum="6BF57E39B84F9F23" modified="2018-01-31" version="1">MSALRALSKHTRSLSRTFAPARAFHSPFKVLSSANSPLTAAPAPSSNVSPLYEKQLDHSPEPTVSSSGTHMYVVSEPDPADTPYAVPSGAYPTSAPYQNYAAAEAPANEGARRASTSPSFAHPITDRAPQNEAGVKESSAIRHAAAPGEMGARGGSEGGLGMMDAQTTKQGQGTLADRNPPPDAVAEKFSKLGVGSAWKERK</sequence>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Barry K."/>
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                <person name="Boyd A."/>
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                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468109">
        <property type="protein sequence ID" value="PCH40664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JVD2"/>
    <dbReference type="OMA" id="AVAGCEK"/>
    <dbReference type="OrthoDB" id="2758200at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH40664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="337" mass="37225" checksum="1B6DCBE35E4FEDB8" modified="2018-01-31" version="1">MAPSMIPPTMVARVLNIHGRLRNSPLYLGQADVQQNVKWVRRGNSDILVLRHEIGDNDENDHAEAEATTQANDAPSTTEVNTSTDTEAEPVQGSDDPAILSAVCEINASDFYMTADGGYQGPTQYIPSFAQVKPTCTGSKPGVVPFTDDFAQVCDNIKALQREITTPGFTHMRGVLSSDEPRFARLKMQHVLFQPKDADDDENNAEDSPHGDIPSFCKIENWPTYSAAAATELQRIIDDGTLDLIPLPAYDRHGDLMFPGQYRNYLTGAVVECHFTLSHWSIKKNNIGMDVFVADVVALRVIIPPTSFTSPRKRRVPPRLDPLSPPSPDAPVKRLRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JWS5</accession>
    <name>A0A2H3JWS5_WOLCO</name>
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        <recommendedName>
            <fullName evidence="7">Ankyrin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WOLCODRAFT_143973</name>
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    <organism evidence="5 6">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD-104</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="PCH42308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:RNA nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24141">
        <property type="entry name" value="2-5A-DEPENDENT RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24141:SF1">
        <property type="entry name" value="2-5A-DEPENDENT RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ANK_REPEAT"/>
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    </dbReference>
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    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="273"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="883"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="600"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="608"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PCH42308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="944" mass="107228" checksum="2B2060E784F332BA" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JX00</accession>
    <name>A0A2H3JX00_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 16">Peroxisome assembly protein 12</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14 16">Peroxin-12</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">WOLCODRAFT_137274</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5 receptor from peroxisomes to the cytosol, thereby promoting PEX5 recycling.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Component of the PEX2-PEX10-PEX12 retrotranslocation channel, composed of PEX2, PEX10 and PEX12.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the pex2/pex10/pex12 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH41254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JX00"/>
    <dbReference type="STRING" id="742152.A0A2H3JX00"/>
    <dbReference type="OMA" id="QHYLARC"/>
    <dbReference type="OrthoDB" id="107372at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990429">
        <property type="term" value="C:peroxisomal importomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016562">
        <property type="term" value="P:protein import into peroxisome matrix, receptor recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16451">
        <property type="entry name" value="mRING_PEX12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017375">
        <property type="entry name" value="PEX12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006845">
        <property type="entry name" value="Pex_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12888:SF0">
        <property type="entry name" value="PEROXISOME ASSEMBLY PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12888">
        <property type="entry name" value="PEROXISOME ASSEMBLY PROTEIN 12 PEROXIN-12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04757">
        <property type="entry name" value="Pex2_Pex12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038074">
        <property type="entry name" value="Peroxisome_assembly_p12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13 16" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 17" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="18">
        <location>
            <begin position="331"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR038074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PCH41254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="382" mass="44239" checksum="084681068D2DB805" modified="2018-01-31" version="1">MQSASDYFTPAMEFFNDVGEDPLKPTLFELVAQEQLRDLLQPALKYVLSVFAQQYPRYLLRIVNRHEEFYALLMLLVERHYLRKHGASFAENFYGLKRRRRPLFEKERAKAAVPGVLPEERLRDKDIWRSLVFLIGLPYLRTKAQEYFEDLGGGVQSEVLEESLASRQARALTEETLAGRLRRAYLTFYPILNTGFEAWLLICNIAYLFDQTPFYRPWLAWMGVEIRRFGIDDLRAAQQALRPRLDDTRKRGLFSALGQMLRRSPRLLLDSFNVVLPTAIFFIKFLEWWYSPSSPARALSTSPQGPVVPPPKAAEPHPQGIPFDRTAYGVCPICHNTFANATALPSGYVFCYRCAYDYVEKRGRCPVTLLPARVWQLRKILI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JX64</accession>
    <name>A0A2H3JX64_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nucleoplasmin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_150796</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH40767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JX64"/>
    <dbReference type="OrthoDB" id="3364132at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH40767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="293" mass="33283" checksum="C9199F3CF1A97BAD" modified="2018-01-31" version="1">MWLESLDKRLHEYRITGDGERTVTCFVASEAGQALTINMEHLLRRDLVLICCQENQVLCSGFSESMELGQIRGVCTSKNTSRSLEFAVVPQPGANESEELNLDDCGSLTIHLRRVKDSWKECYREPQSQPVDLQCRKAGTHYITLGEEYQTRTLFQAARHFDHQEAPFATFVFKFGPREFLEAKGIIPETEADLTSEQGPFEGAGYREPSCDEACSVTPDDPPKRVRFSASPEPQYFEVLSPVSSDDEEDTDDEESDEDENDWSLKKLPHPEPQSYIGHSEDGLAIMVVNYWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JY07</accession>
    <name>A0A2H3JY07_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="10">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WOLCODRAFT_122610</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PPP phosphatase family. PP-5 (PP-T) subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="10"/>
    <dbReference type="EMBL" id="KB468146">
        <property type="protein sequence ID" value="PCH43789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JY07"/>
    <dbReference type="STRING" id="742152.A0A2H3JY07"/>
    <dbReference type="OMA" id="IHKKYAF"/>
    <dbReference type="OrthoDB" id="445564at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07417">
        <property type="entry name" value="MPP_PP5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041753">
        <property type="entry name" value="PP5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013235">
        <property type="entry name" value="PPP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051134">
        <property type="entry name" value="PPP_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45668">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45668:SF5">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08321">
        <property type="entry name" value="PPP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033096">
        <property type="entry name" value="PPPtase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 9" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="10"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="11">
        <location>
            <begin position="222"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="8">
        <location>
            <position position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR033096-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PCH43789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="439" mass="49485" checksum="B5B363BE41A846E9" modified="2018-01-31" version="1">MAIQLDPKYAKAYYRRATCYLQTLQYKQAIADFRKLLTLEPQNQLVRTQMDSTQKIMRKTEFEKAIEMEEEASAADRCLEIIAEGGCDIERDYNGPKLPMNDEGKYGINAEFIQAMIEWFKDGKTLPRRYVWEIALGAHGHFVQEESLVMLDLEDGMTCDVIGDVHGQFYDMLHLYSLTGTPTEKHCLLMNGDLVDRGSWSMEVIITALAYKWLYPKRMYINRGNHETKEMNRTYGFEGEAKHKHGEQTYKLFAHLFTTMPLATLISATKPPSGPTDKAILSPKGLKRYFVVHGGLFSQDGVTLEDIRKIDRIGRQPGQEGLMCLLWTDPQETPGRGPSKRGVGIAFGPDVTKRWCQANGVTGIIRSHEVRQDGYAIEHDGLCTTVFSAPNYVDQAGNRGAFIRIDAAGTQEYTQFDAKPHPPMKPMAYASGGLASLLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JYA8</accession>
    <name>A0A2H3JYA8_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">adenosine deaminase</fullName>
            <ecNumber evidence="4">3.5.4.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WOLCODRAFT_70220</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>adenosine + H2O + H(+) = inosine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:24408"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. ADGF subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.4" evidence="4"/>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH41724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JYA8"/>
    <dbReference type="STRING" id="742152.A0A2H3JYA8"/>
    <dbReference type="OMA" id="FQACFGP"/>
    <dbReference type="OrthoDB" id="7202371at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004000">
        <property type="term" value="F:adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006154">
        <property type="term" value="P:adenosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046103">
        <property type="term" value="P:inosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000017">
        <property type="entry name" value="Adenosine deaminase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001365">
        <property type="entry name" value="A_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409">
        <property type="entry name" value="ADENOSINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409:SF39">
        <property type="entry name" value="ADENOSINE DEAMINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00962">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Adenosine deaminase" evidence="10">
        <location>
            <begin position="225"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PCH41724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="552" mass="62290" checksum="E4C8087CAC620BD9" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JZC6</accession>
    <name>A0A2H3JZC6_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_73896</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468135">
        <property type="protein sequence ID" value="PCH43238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JZC6"/>
    <dbReference type="OMA" id="MSTCLAP"/>
    <dbReference type="OrthoDB" id="2796825at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH43238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="329" mass="36382" checksum="6844A59348FBB8A5" modified="2018-01-31" version="1">MKSSQFQNSLYIGNNLNGILYGAKLVLYIISMRSLLTSRQRSSSDNFYILFSTALLLLITVFVVTQAIFGGEMWIANAGYPGGPSAYLNRYASVWYETLGTAASVVLNLLADALMIYRCHVVYNNRMLLLMLSVIYIGSIATGVFLICTSGLPSGNFFDGLAAKSGTAYYVTTIALNIISTALICGRIHMYAKRISADKDTIVLHCRSHNVVIIIIESALPYTLCGVAFLVSHGVKNGVEILFLSTYTMFTCISPQLIIMRIVTGRAWIAHRKEITRPMTNPTRQSQREYDMEEQAQNLGMTGTDSTVVNVELHTISRTDFSLSDDVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K1K2</accession>
    <name>A0A2H3K1K2_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tetrapyrrole biosynthesis uroporphyrinogen III synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_73844</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468135">
        <property type="protein sequence ID" value="PCH42904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K1K2"/>
    <dbReference type="STRING" id="742152.A0A2H3K1K2"/>
    <dbReference type="OMA" id="IHGADTG"/>
    <dbReference type="OrthoDB" id="5595751at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004852">
        <property type="term" value="F:uroporphyrinogen-III synthase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
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        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
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        <property type="term" value="P:uroporphyrinogen III biosynthetic process"/>
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    </dbReference>
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        <property type="entry name" value="HemD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10090">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036108">
        <property type="entry name" value="4pyrrol_syn_uPrphyn_synt_sf"/>
    </dbReference>
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        <property type="entry name" value="4pyrrol_synth_uPrphyn_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039793">
        <property type="entry name" value="UROS/Hem4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12390">
        <property type="entry name" value="UROPORPHYRINOGEN III SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12390:SF0">
        <property type="entry name" value="UROPORPHYRINOGEN-III SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HEM4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HemD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tetrapyrrole biosynthesis uroporphyrinogen III synthase" evidence="1">
        <location>
            <begin position="16"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH42904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="296" mass="32678" checksum="7B8C5322F80967AE" modified="2018-01-31" version="1">MSRVLLLRTPTADGPDRYETAFETRGYRPISVPVLETTYTNLDHLKTKVLEGPGKHGYNGVVITSGRSCEAWKTVTLELAEDDPDIDEEHSAAWANVPFYVVGEATEKALFQIREIVGKYPSVPRDIRGARDAGTSERLAHLILKDLSSDSKEGKRLLYLTGDKNRDTLPSILTDEGISLDSLQVYETRGSTKFADDLQKALYAFSGHVPHLRLWIVFFAPSDAQYATPMLREHFHLPAATDTPEVASKPVPQIAAIGPTTATSLREDLHLSVHIVSPKPNAASLAQAVLEYDNEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K2M2</accession>
    <name>A0A2H3K2M2_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ras-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WOLCODRAFT_25847</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="PCH43304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="8830751at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007163">
        <property type="term" value="P:establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000573">
        <property type="entry name" value="RHO family GTPase Rho2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0636">Prenylation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PCH43304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="210" mass="23125" checksum="82491D429C16058A" modified="2018-01-31" version="1">MSSQNPIRRKLVIVGDGACGKTSLLCSFALGEFPKEYHPTIFENYVAEIRLDGKPVQLALWDTAGQEEYERLRPMSYSKSHVILIAFAIDTPDSLENVTVKWIEEVRAICGQTIPVLLVGCKSDLRPRVGSPNSGNFVSQADAERVAQLIGARAYKECSALRIEGVDDVFEAATRASMLMREGVPAHVPSAHERRTSRGDWEGGRCCVVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K319</accession>
    <name>A0A2H3K319_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_153494</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468146">
        <property type="protein sequence ID" value="PCH43434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K319"/>
    <dbReference type="OMA" id="HFTNPTI"/>
    <dbReference type="OrthoDB" id="3364736at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004354">
        <property type="entry name" value="Meiotic_Rec114"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03525">
        <property type="entry name" value="Meiotic_rec114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="185"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH43434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="489" mass="53516" checksum="4C41007ADED64F1D" modified="2018-01-31" version="1">MSQSTTSTTTYNLIKYSRSYAQSNGESQQAEQEWQHFTNPVIRLVLDATKSSATGELEAFRLRVLWNLSAGPDAMDTDQRDVMFEDIDMLSLSIMQHGVPSQHGLPLKAVYRDSVVGIRYLHSRTGAVPSFRRFQVTFQSATLVSSFIDAIKYICPCKVNPPPPVRKTMARSTTMMPPPAITQAVSHQPPVSVQGSSQQVSQADAPRIQRAMSVAGVLNQPSTPATDPARHPGPPSQSPRDATPWNSSSQLDQQSRTVASDEVSSRQVIAPSLRRSSTALPSSAPLQLPAANNAASWDPPSHLRTLPPSDDYIQSRPSSAITASSAVADYSFHASSEAAQSERLRTLSELEYTVQLRPPAAIDLTAAPADAHLEPDSIYARRLHADIPPPLVPPHLVQQINSSTEYVVQPASVLRLTETAPVSGDVLKATEDTPMQDLITTLEEVPTLYNLPREELERLVARVVREEGFVKLLENLDSMWTIKSYLGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3ITB9</accession>
    <name>A0A2H3ITB9_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Poly A polymerase head domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WOLCODRAFT_159930</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.</text>
    </comment>
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        <property type="protein sequence ID" value="PCH33236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="742152.A0A2H3ITB9"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="term" value="F:ATP:3'-cytidine-cytidine-tRNA adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:CC tRNA cytidylyltransferase activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:nucleotide binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001680">
        <property type="term" value="P:tRNA 3'-terminal CCA addition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="NT_ClassII-CCAase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="tRNA nucleotidyltransferase cca2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3090.10">
        <property type="entry name" value="cca-adding enzyme, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002646">
        <property type="entry name" value="PolA_pol_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032828">
        <property type="entry name" value="PolyA_RNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13734:SF5">
        <property type="entry name" value="CCA TRNA NUCLEOTIDYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13734">
        <property type="entry name" value="TRNA-NUCLEOTIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01743">
        <property type="entry name" value="PolyA_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12627">
        <property type="entry name" value="PolyA_pol_RNAbd"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81891">
        <property type="entry name" value="Poly A polymerase C-terminal region-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly A polymerase head" evidence="7">
        <location>
            <begin position="33"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding" evidence="8">
        <location>
            <begin position="200"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="527"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="535"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU003953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12627"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH33236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="551" mass="61572" checksum="F6207CB5C362604C" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IUJ0</accession>
    <name>A0A2H3IUJ0_WOLCO</name>
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        <recommendedName>
            <fullName evidence="9">DUF803-domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="7" type="ORF">WOLCODRAFT_135239</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="PCH33650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570:SF86">
        <property type="entry name" value="ADR321CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="313"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="344"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="371"/>
            <end position="393"/>
        </location>
    </feature>
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            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="421"/>
            <end position="639"/>
        </location>
    </feature>
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        <location>
            <begin position="219"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="230"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="243"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="427"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="488"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="522"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="584"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="626"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PCH33650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="655" mass="70810" checksum="F1D306D245AB6A22" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IV28</accession>
    <name>A0A2H3IV28_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Cyclophilin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">WOLCODRAFT_87074</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">May catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides thereby assisting the folding of proteins. May also function as a chaperone, playing a role in intracellular transport of proteins. May also have a protein ubiquitin ligase activity acting as an E3 ubiquitin protein ligase or as a ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 17">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cyclophilin-type PPIase family. PPIL2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH33850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3IV28"/>
    <dbReference type="STRING" id="742152.A0A2H3IV28"/>
    <dbReference type="OMA" id="NFIKHCA"/>
    <dbReference type="OrthoDB" id="407558at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16663">
        <property type="entry name" value="RING-Ubox_PPIL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000014">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase cyp65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026951">
        <property type="entry name" value="PPIL2_U-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF1">
        <property type="entry name" value="RING-TYPE E3 UBIQUITIN-PROTEIN LIGASE PPIL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0697">Rotamase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="U-box" evidence="14">
        <location>
            <begin position="33"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="13">
        <location>
            <begin position="272"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="469"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="470"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00007930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PCH33850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="522" mass="56442" checksum="8A6D21E8BE042C1F" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IV75</accession>
    <name>A0A2H3IV75_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NEDD8-conjugating enzyme UBC12</fullName>
            <ecNumber evidence="7">2.3.2.34</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">NEDD8-conjugating enzyme Ubc12</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">RUB1-conjugating enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Ubiquitin carrier protein 12</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">WOLCODRAFT_135377</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine + [E2 NEDD8-conjugating enzyme]-L-cysteine = [E1 NEDD8-activating enzyme]-L-cysteine + [E2 NEDD8-conjugating enzyme]-S-[NEDD8-protein]-yl-L-cysteine.</text>
            <dbReference type="EC" id="2.3.2.34"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein neddylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.34" evidence="7"/>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH33892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3IV75"/>
    <dbReference type="STRING" id="742152.A0A2H3IV75"/>
    <dbReference type="OMA" id="CQVDFPD"/>
    <dbReference type="OrthoDB" id="10249039at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061654">
        <property type="term" value="F:NEDD8 conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23794">
        <property type="entry name" value="UBCc_UBE2F_UBE2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000005">
        <property type="entry name" value="NEDD8-conjugating enzyme Ubc12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
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<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IWK7</accession>
    <name>A0A2H3IWK7_WOLCO</name>
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        <submittedName>
            <fullName evidence="13">Nucleoside triphosphate hydrolase protein</fullName>
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        <name evidence="13" type="ORF">WOLCODRAFT_63998</name>
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    <organism evidence="13 14">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
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            <strain evidence="13 14">MD-104</strain>
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        <subcellularLocation>
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    </dbReference>
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    <feature type="transmembrane region" description="Helical" evidence="11">
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            <end position="1107"/>
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        <location>
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        <location>
            <begin position="1154"/>
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        </location>
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        <location>
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            <begin position="465"/>
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        </location>
    </feature>
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        <location>
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    </feature>
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        </location>
    </feature>
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            <end position="816"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IX17</accession>
    <name>A0A2H3IX17_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_15220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EXO5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH34271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3IX17"/>
    <dbReference type="OMA" id="FRDECEW"/>
    <dbReference type="OrthoDB" id="354769at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045145">
        <property type="term" value="F:single-stranded DNA 5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019190">
        <property type="entry name" value="EXOV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14464">
        <property type="entry name" value="EXONUCLEASE V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14464:SF4">
        <property type="entry name" value="EXONUCLEASE V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09810">
        <property type="entry name" value="Exo5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="76"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="481"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH34271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="710" mass="78628" checksum="6C3FEEC4D33DEC2B" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IXD6</accession>
    <name>A0A2H3IXD6_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Tafazzin family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">WOLCODRAFT_106350</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine = a cardiolipin + a 1-acyl-sn-glycero-3-phosphocholine</text>
            <dbReference type="Rhea" id="RHEA:33731"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="ChEBI" id="CHEBI:62237"/>
            <dbReference type="ChEBI" id="CHEBI:64743"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:33732"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="11">
            <dbReference type="Rhea" id="RHEA:33733"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Intermembrane side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Mitochondrion outer membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
            <orientation evidence="10">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the taffazin family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467832">
        <property type="protein sequence ID" value="PCH34660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3IXD6"/>
    <dbReference type="STRING" id="742152.A0A2H3IXD6"/>
    <dbReference type="OMA" id="EIMFTNP"/>
    <dbReference type="OrthoDB" id="193467at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047184">
        <property type="term" value="F:1-acylglycerophosphocholine O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035965">
        <property type="term" value="P:cardiolipin acyl-chain remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007007">
        <property type="term" value="P:inner mitochondrial membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07989">
        <property type="entry name" value="LPLAT_AGPAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000872">
        <property type="entry name" value="Tafazzin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12497:SF0">
        <property type="entry name" value="TAFAZZIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12497">
        <property type="entry name" value="TAZ PROTEIN TAFAZZIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00979">
        <property type="entry name" value="TAFAZZIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="13">
        <location>
            <begin position="53"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PCH34660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="276" mass="30861" checksum="7170D72F23842536" modified="2018-01-31" version="1">MAADILSKATVGAVGLLCKTFLHIGYCSSVTVNGLDNLRTALEDVGRNEGRGVITICNHISTLDDPLVWGVLPARFYLSSRMTRWTLGASDIMFTNPIFSFFFRKGQVIETFRGKGIFQPAIDDAVRKLNDSAWIHLFCEGKVNQPVLEPARLLRFKWGVGRILMEADTPPTIIPMWLTGFDQLMPENRATPWKFFPRPRVALSVTFGRPIDTNEVRESLARAIRENKTPEVPANTVTEAKGAESVRSAVTALLQRKVEELGREVTRRRMSGDVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IZB3</accession>
    <name>A0A2H3IZB3_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_27611</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467843">
        <property type="protein sequence ID" value="PCH35061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3IZB3"/>
    <dbReference type="STRING" id="742152.A0A2H3IZB3"/>
    <dbReference type="OrthoDB" id="2340858at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH35061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="239" mass="26960" checksum="DFE1802C8D795D4E" modified="2018-01-31" version="1" fragment="single">MPSRLVSRRQSKSWDHLQRAIPSSEEGPGTLSHQLVAVHVKTDGGRSEDKFYLDFKSDHIRDRIRDQLGVIQIRKALSMLRVCLFVSHTASLGGLLFECLAHQYLSGLTETPLALPPLLRMQRHPNGRTFRVDDALSTAASTATRSLPIRRRTIGEFQWDNSKDLELTLPLETHFYIPKAQNNPLLDSFMIEYNGNVATLWIFQMTVGKTHGGSARGYDLIASVEKFVRGQLHKRANAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IZR6</accession>
    <name>A0A2H3IZR6_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">UbiA prenyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WOLCODRAFT_80926</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
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            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <sequence length="295" mass="33067" checksum="90D659C65301B4D3" modified="2018-01-31" version="1">MLTVVTQTFYGVLYHLYTPFLFTKSDIKTTLVPVTFFALAASHRVAVEHIPHAILWLWLHLLHFNVANQAARPEEDQHNKAWRPIPSGRMTSKNAMILRWLLVPVYWAISWLYGYQTLAVSIAFVALTVAYNELSIDGGHWIGRNVLNALGTAAFEIGTTLLTCNSAALDKVGTRSILISAGVIATTIHAQDFQDVPGDKKVGRRTLPIVNPTSARLSIPIGLICWTAVAVSIWGVDWFTVMSLAAMAVFIGWRYVFLTTIRDDEVSYIWYNVWMSCVHALPAYYRIAQRSVTVL</sequence>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
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                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
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                <person name="Benoit I."/>
                <person name="Boyd A."/>
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                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
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                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
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                <person name="Sabat G."/>
                <person name="Salamov A."/>
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                <person name="St John F."/>
                <person name="Stenlid J."/>
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                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
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                <person name="Martin F."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD-104</strain>
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    </comment>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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    </evidence>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
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                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
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                <person name="Stenlid J."/>
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                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
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                <person name="Martin F."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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                <person name="Barry K."/>
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                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
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                <person name="Benoit I."/>
                <person name="Boyd A."/>
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                <person name="Ferreira P."/>
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                <person name="Gaskell J."/>
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                <person name="Heitman J."/>
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                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
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                <person name="Kumar T.K.A."/>
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                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
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            </authorList>
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        </citation>
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            <strain evidence="2 3">MD-104</strain>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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                <person name="Martinez A.T."/>
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                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
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                <person name="Benoit I."/>
                <person name="Boyd A."/>
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                <person name="Coutinho P.M."/>
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                <person name="Ferreira P."/>
                <person name="Findley K."/>
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                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
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                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
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            </authorList>
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        </citation>
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            <strain evidence="2 3">MD-104</strain>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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</entry>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Martinez A.T."/>
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                <person name="Spatafora J.W."/>
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                <person name="Hesse C."/>
                <person name="Hori C."/>
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                <person name="Jurgens J.A."/>
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                <person name="Kersten P."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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        <property type="entry name" value="DUF1275"/>
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    <dbReference type="PANTHER" id="PTHR37488">
        <property type="entry name" value="DUF1275 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37488:SF2">
        <property type="entry name" value="DUF1275 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06912">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH36250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="256" mass="26929" checksum="B27F8C5A47A49538" modified="2018-01-31" version="1">MPDNDPEPAPPNAALLLLCLCTGLVDSLTYVSSGVWCAFVTGTTIQLGMDIPIALSYLLSAKFQPDAFHRIASSSSSVRFASLIGFLVGGHASSHSLLATNPAISSTMQAALLVLASTVILSRAGTSPLVVGIPHAHITLPIVSASMAIQAVLVQHYHTAYATSVAWTSVWLSIVTPSSARSRLYKIAGLIVLIIGAGIGTVVLGRVDGDEQTESGEDRARRVGWGLLAAAGIKLIAAVMFRVQRHKHIHEGRIHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J1Z2</accession>
    <name>A0A2H3J1Z2_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Peptidase S28</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WOLCODRAFT_28272</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S28 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467865">
        <property type="protein sequence ID" value="PCH36001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J1Z2"/>
    <dbReference type="OMA" id="MRYFRNA"/>
    <dbReference type="OrthoDB" id="1735038at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070008">
        <property type="term" value="F:serine-type exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008758">
        <property type="entry name" value="Peptidase_S28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010">
        <property type="entry name" value="PROTEASE S28 PRO-X CARBOXYPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010:SF23">
        <property type="entry name" value="SERINE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05577">
        <property type="entry name" value="Peptidase_S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013581407" evidence="6">
        <location>
            <begin position="21"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PCH36001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="519" mass="57464" checksum="ACBA78911EBFDB66" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J215</accession>
    <name>A0A2H3J215_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fungal pheromone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_192021</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467876">
        <property type="protein sequence ID" value="PCH36300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J215"/>
    <dbReference type="OrthoDB" id="2753862at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH36300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="37" mass="3877" checksum="84BE91F6A19DA9DA" modified="2018-01-31" version="1">MDAFFTIAAPVPAEETEQVPADYDTSNGSANSNCTIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J238</accession>
    <name>A0A2H3J238_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UreD-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_94309</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UreD family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH33843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J238"/>
    <dbReference type="STRING" id="742152.A0A2H3J238"/>
    <dbReference type="OMA" id="CFRSASY"/>
    <dbReference type="OrthoDB" id="5550464at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01384">
        <property type="entry name" value="UreD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002669">
        <property type="entry name" value="UreD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33643">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33643:SF1">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01774">
        <property type="entry name" value="UreD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH33843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="298" mass="32924" checksum="BA21E4E022DAA8B8" modified="2018-01-31" version="1">MNALAGIGRIVLRAHGTEAVFSELSSAYPLKLLSPRIHQDCVSLVYILTYGGGLVGGDRIDLSVEIQAKVALVMLSQGSTKVFKTRPGQRLSARSQGTSSDAVTTQIMNVVVEESGALFLLPDPVTCFRSARYNQLQTFRLIGNASAVILDWVTSGRRSIGEEWVFSRYYSLNEVWVDEECVARDVMLLEEQLQVPGLPARTLADTLAPYSCYATLIMYGPLVQDTIRFLSGEYARITVFKHSSPPNLLWSFSPIRDGNGCIVRVAAKGSEDVKMWFSEMLKPLESVVGIDIYRKAFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J254</accession>
    <name>A0A2H3J254_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_140209</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
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                <person name="Kersten P."/>
                <person name="Kohler A."/>
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                <person name="Lindquist E."/>
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        <location>
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        </location>
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        <location>
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            <end position="338"/>
        </location>
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            <begin position="41"/>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH36331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="338" mass="35993" checksum="531ECFADBE4B26B1" modified="2018-01-31" version="1">MIRSAVTAAVLALPLAASAVHQDAALRRRHAGLAHSPTYMRRASNYTLQNKFVGEDFLYVASNWNFFSESDPTSGLVQYLDADAAEAAGLATVDCNNVTTLAVDTNETVSIGGLRKSVRISSPETYNSGLFIADFQAMPFGCGLWPAYWTVSASATWPDGGEIDIIEGVNLNTENQITLHSGPDCTLNNTQKVTSNLDGTQCASSPGADSGCAYSQTDPRSFGAGFNNASGGVFAHLWNTDGVTVWFFSRDEIPSDITAGTPDPTSWGTPAAIFPDTGCDISSHFYDHAIVLDTTICGDWAGPAYTSSGCPGTCEEIVANATNFENAKWLVNYISVYQ</sequence>
</entry>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Floudas D."/>
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                <person name="Barry K."/>
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                <person name="Martinez A.T."/>
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                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
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                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
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                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
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                <person name="Ling A."/>
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                <person name="Lundell T."/>
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                <person name="Nagy L.G."/>
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                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
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                <person name="St John F."/>
                <person name="Stenlid J."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
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        <source>
            <dbReference type="EMBL" id="PCH36820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="146" mass="17024" checksum="A89F4C0757E692C7" modified="2018-01-31" version="1">MIIGYVFGLAQCNSLETVTLQALNFERVGYAWMRRILESNVSKNLREVSIIVDRPYYNQNAKKNLQMTVSALRKDMCPQLNELFSNKKYEKLHHVDFVLQTSPDEAIPDAFRWSTLLKAEMPKLVERGVLRTRVDVFLDLWNEDAL</sequence>
</entry>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
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                <person name="Benoit I."/>
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                <person name="Carlson A."/>
                <person name="Copeland A."/>
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                <person name="Ferreira P."/>
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                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
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                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
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                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
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                <person name="Sabat G."/>
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                <person name="Wiebenga A."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="8">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
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        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="PCH33419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="BET1_SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12791">
        <property type="entry name" value="GOLGI SNARE BET1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
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        <location>
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            <end position="106"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
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        </location>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00046280"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PCH33419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="136" mass="15631" checksum="7526B03E0D1EE185" modified="2018-01-31" version="1">MSQRFRATASLRDRSALLPDYYTPPSSGRSSPFQPQPSGHRFADDLEGQNDEHLEGLAAKVKILKDITVGIGNEVRESTVQLSQMNDAFSETSGILAGTFRRVNNMAARQGCRWLWYIVFLIVVFWFFIVVWWFRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J4B3</accession>
    <name>A0A2H3J4B3_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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        <lineage>
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            <taxon>Phaeolaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467909">
        <property type="protein sequence ID" value="PCH37092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J4B3"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH37092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="264" mass="27513" checksum="05F923EF9727C06B" modified="2018-01-31" version="1">MPPLSIRAGTCTAFITVNLFPAIEFTFSGEARRCISVASNGRPPLSRDAREFQDVAIEILRVGPSATRTSTIIQLAQYLHLHASRRRAGSHAPCGRRLLSPLREAGRACLVAMHTQAGVHGHAAGCAPSALAVARLARVEAVALGARPHQRGINPRLWRGAASAAAATIRTTTTCRRADGGCAAVQAQAVARRPSPAVRTARGASNAHRGARRPVPGAGAIGARAWMGIGELVVGGCRGGRMPVCGGLRARAGGSRAVQLVRMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J4C9</accession>
    <name>A0A2H3J4C9_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aspartate--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="3">6.1.1.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Aspartyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">WOLCODRAFT_22110</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Asp) + L-aspartate + ATP = L-aspartyl-tRNA(Asp) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19649"/>
            <dbReference type="Rhea" id="RHEA-COMP:9660"/>
            <dbReference type="Rhea" id="RHEA-COMP:9678"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.12" evidence="3"/>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH33599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J4C9"/>
    <dbReference type="STRING" id="742152.A0A2H3J4C9"/>
    <dbReference type="OMA" id="WVHEIRD"/>
    <dbReference type="OrthoDB" id="372395at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04320">
        <property type="entry name" value="AspRS_cyto_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00776">
        <property type="entry name" value="AsxRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000013">
        <property type="entry name" value="Aspartate--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000132">
        <property type="entry name" value="Aspartyl-tRNA synthetase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02075">
        <property type="entry name" value="Asp_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004523">
        <property type="entry name" value="Asp-tRNA_synthase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00458">
        <property type="entry name" value="aspS_nondisc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003483">
        <property type="entry name" value="PRK05159.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450:SF1">
        <property type="entry name" value="ASPARTATE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450">
        <property type="entry name" value="ASPARTYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="14">
        <location>
            <begin position="241"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="20"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PCH33599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="549" mass="61609" checksum="375976A2B17DF2CE" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J4G8</accession>
    <name>A0A2H3J4G8_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WOLCODRAFT_140503</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD-104</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PheA/TfdB FAD monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467887">
        <property type="protein sequence ID" value="PCH36565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J4G8"/>
    <dbReference type="STRING" id="742152.A0A2H3J4G8"/>
    <dbReference type="OMA" id="ITADIRI"/>
    <dbReference type="OrthoDB" id="2690153at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2450">
        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
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        <property type="entry name" value="FAD-bd"/>
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        <property type="entry name" value="FAD/NAD-bd_sf"/>
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        <property type="entry name" value="RIFMO-like"/>
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        <property type="entry name" value="Thioredoxin-like_sf"/>
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        <property type="entry name" value="BINDING MONOOXYGENASE, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNGMNOXGNASE"/>
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        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="7"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00007801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PCH36565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="558" mass="61184" checksum="7DAC960E9ABA47CB" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J525</accession>
    <name>A0A2H3J525_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amino acid transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WOLCODRAFT_92321</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB467920">
        <property type="protein sequence ID" value="PCH37296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J525"/>
    <dbReference type="STRING" id="742152.A0A2H3J525"/>
    <dbReference type="OMA" id="TIVFMFP"/>
    <dbReference type="OrthoDB" id="4476201at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF6">
        <property type="entry name" value="GABA-SPECIFIC PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="242"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="281"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="335"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PCH37296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="389" mass="42836" checksum="B5B9899B9B6A04DC" modified="2018-01-31" version="1">MYKHREFKRSFLLLEVFGLVFSIFGLFLSICTRFVLTYALPNGGPVALVWGWGICSCFIFTIALAMAELGFAAPTSGGLYYYHAHLNTIGLIAGIASIDWGCVVQLMAAVSIRSNQNFSATTGQTLSRFLQLYLTVIIAFPAATPDEFINSTRYAFGGFDNFSGWPDGFAFVLSFLAPLWTISKFDSSLHISEEAPMLVQQFSINVAITFRMGTDLERIVNTPTDQPMAMILYNSLSEKGTLAVWSVVITVQSFMGTSLVRGFGLPFSGWLYRVNHHMKTPINCAWVAASVTFLLGLLTFTGLPIAMIAVAWMAFSIITLVFPTSPRPTPADMNYTMVVLCGWIVLCLIYYYLPVYGGVHWFCGSITNAGISNVPASRDKVSSVEEDLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J5P6</accession>
    <name>A0A2H3J5P6_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein-S-isoprenylcysteine O-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WOLCODRAFT_92412</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + S-adenosyl-L-methionine = [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:21672"/>
            <dbReference type="Rhea" id="RHEA-COMP:12125"/>
            <dbReference type="Rhea" id="RHEA-COMP:12126"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90510"/>
            <dbReference type="ChEBI" id="CHEBI:90511"/>
            <dbReference type="EC" id="2.1.1.100"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.100" evidence="5"/>
    <dbReference type="EMBL" id="KB467931">
        <property type="protein sequence ID" value="PCH37526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J5P6"/>
    <dbReference type="STRING" id="742152.A0A2H3J5P6"/>
    <dbReference type="OMA" id="CETIITC"/>
    <dbReference type="OrthoDB" id="422086at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004671">
        <property type="term" value="F:protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007269">
        <property type="entry name" value="ICMT_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12714">
        <property type="entry name" value="PROTEIN-S ISOPRENYLCYSTEINE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12714:SF9">
        <property type="entry name" value="PROTEIN-S-ISOPRENYLCYSTEINE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04140">
        <property type="entry name" value="ICMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013843790" description="Protein-S-isoprenylcysteine O-methyltransferase" evidence="6">
        <location>
            <begin position="19"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PCH37526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="230" mass="25441" checksum="8567F8EE3BDBF675" modified="2018-01-31" version="1">MHCTVFLKIPLLILGATCSHIACTNPNPSPKVEESQKYNGGDWLTRFHEIVVKVIKTLAILAAYQPSSISKHILDILTTSGGHSATQIRFTLAFYTGILLQLFGGITRKICYRALGQHFTFSLTVQEDHQLVTTGPYSIVRHPAYIVAIAGSIGMLMVQLGSGSWWSECGASETSIGRLLAVVWVASMITIMAGAVSRVDQEDRVLRREFGIQWDTWSKNTPYRLIPGIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J6V8</accession>
    <name>A0A2H3J6V8_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein PNS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WOLCODRAFT_135946</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Probably involved in transport through the plasma membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the CTL (choline transporter-like) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH37946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J6V8"/>
    <dbReference type="STRING" id="742152.A0A2H3J6V8"/>
    <dbReference type="OMA" id="LIVLWTW"/>
    <dbReference type="OrthoDB" id="420519at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007603">
        <property type="entry name" value="Choline_transptr-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE (SLC FAMILY 44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385:SF88">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE PROTEIN CTL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04515">
        <property type="entry name" value="Choline_transpo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="274"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="312"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="366"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="404"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="474"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="573"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="606"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="16"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="661"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="73"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="153"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="665"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="685"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="704"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="743"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="777"/>
            <end position="786"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PCH37946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="797" mass="87043" checksum="13D977D65197F79C" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J6W9</accession>
    <name>A0A2H3J6W9_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phosphoserine transaminase</fullName>
            <ecNumber evidence="4">2.6.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WOLCODRAFT_135989</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>4-(phosphooxy)-L-threonine + 2-oxoglutarate = (R)-3-hydroxy-2-oxo-4-phosphooxybutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:16573"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58452"/>
            <dbReference type="ChEBI" id="CHEBI:58538"/>
            <dbReference type="EC" id="2.6.1.52"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-phospho-L-serine + 2-oxoglutarate = 3-phosphooxypyruvate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:14329"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:18110"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57524"/>
            <dbReference type="EC" id="2.6.1.52"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.52" evidence="4"/>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH38012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J6W9"/>
    <dbReference type="STRING" id="742152.A0A2H3J6W9"/>
    <dbReference type="OMA" id="AFVYFCD"/>
    <dbReference type="OrthoDB" id="1703350at2759"/>
    <dbReference type="UniPathway" id="UPA00135">
        <property type="reaction ID" value="UER00197"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004648">
        <property type="term" value="F:O-phospho-L-serine:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000010">
        <property type="entry name" value="Phosphoserine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000006">
        <property type="entry name" value="Phosphoserine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00160">
        <property type="entry name" value="SerC_aminotrans_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022278">
        <property type="entry name" value="Pser_aminoTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003764">
        <property type="entry name" value="PRK05355.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43247">
        <property type="entry name" value="PHOSPHOSERINE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43247:SF1">
        <property type="entry name" value="PHOSPHOSERINE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000525">
        <property type="entry name" value="SerC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5 13" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0718">Serine biosynthesis</keyword>
    <keyword evidence="7 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="12">
        <location>
            <begin position="9"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PCH38012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="404" mass="44037" checksum="EBF8895FD757E39B" modified="2018-01-31" version="1">MASDHARVINFGAGPSALPVTVLEEATKGLLNFQQTGIGIAEVSHRSKEFQAFLASVEASIRAQLDVPPTHRILFTQGGGSGQFSAVVYNMLARYRLLHPERSAADTVVDYVVTGSWSKKAAEEARRLGGAQVNIVVDSKQFSESGKVFDRIPPHDAYKFSEDPALVYYCENETVDGVEFSHEDSAPASFPFHLLQKGNALAPLVADYSSSFMCRPIPHLADHAVIYAGAQKNIGPAGLTILIVREDCIVDVDAAARLGAAPVPITMSYKTLADAGSLYNTPSVLPIYVAGLVLERMQRHGGMKHYEETNRHKAEKVYAVVKKGEQQGKLRRKVQEGSGSWMNVVFEVVGSDAEKKFLEGAEKRGMKGLKGHRSVGGIRVSLYNAVTEAEVDRLVDYIDNFINE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J700</accession>
    <name>A0A2H3J700_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cerato-platanin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WOLCODRAFT_114700</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cerato-platanin family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH38042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J700"/>
    <dbReference type="STRING" id="742152.A0A2H3J700"/>
    <dbReference type="OMA" id="QLNASAC"/>
    <dbReference type="OrthoDB" id="4898945at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd22778">
        <property type="entry name" value="DPBB_CEPL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010829">
        <property type="entry name" value="Cerato-platanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07249">
        <property type="entry name" value="Cerato-platanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PCH38042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="106" mass="10975" checksum="FDA479D60E26CEB7" modified="2018-01-31" version="1" fragment="single">AALAQSTVPVSYDTTYDNSTSSLNVTACSYELERLGFTTLGSLPDFPYIGGASVVPPNGSSGCGTCWELEYDGNTVAILAVDYTQEGFNLAKEATASQVDSSACGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J7A2</accession>
    <name>A0A2H3J7A2_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PIN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_139464</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467832">
        <property type="protein sequence ID" value="PCH34609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J7A2"/>
    <dbReference type="STRING" id="742152.A0A2H3J7A2"/>
    <dbReference type="OMA" id="VRRTICC"/>
    <dbReference type="OrthoDB" id="69928at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13638">
        <property type="entry name" value="PIN_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PIN" evidence="2">
        <location>
            <begin position="98"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH34609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="386" mass="41595" checksum="B032C6C9DC917AD6" modified="2018-01-31" version="1">MAQTKGAAIASNKLAMSRALGAAFLNHQVQQLEKTVTDVGPGGGNWRERRNPNVHDHHKRSRAAPAKAPSKRDGEVADADFDRTRKREAAAVKDADIIVVDASVLVHALSQVKKWCRDGREEVIIVPLEALNTLDLLKKGMSSLAQRARAASRILEAQVGTNPRIRVQRDDAFVLWDSIFDNKVAPPTGSPEWVRRTICCARWEVNHATAPATATAAAAPKPRVVLAVLSQSAEAQSEAIFPPHAHASSSPVPLPAPQTNRHEPRSSGALVTQWAAKAGIEVFEVTPGADAGRGPHNTSPSRDAAANGRRSPQTTRQAPEGERKRGVRRNSYRFDGERPVMAGGRAGAGVGLVERPPAVMAMMEMVAQPQRVVRVLARGEKLEPDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J7B1</accession>
    <name>A0A2H3J7B1_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">2-isopropylmalate synthase</fullName>
            <ecNumber evidence="5">2.3.3.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WOLCODRAFT_135865</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3-methyl-2-oxobutanoate + acetyl-CoA + H2O = (2S)-2-isopropylmalate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21524"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.13" evidence="5"/>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH37821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J7B1"/>
    <dbReference type="STRING" id="742152.A0A2H3J7B1"/>
    <dbReference type="OMA" id="WPDKVID"/>
    <dbReference type="OrthoDB" id="418791at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003852">
        <property type="term" value="F:2-isopropylmalate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07942">
        <property type="entry name" value="DRE_TIM_LeuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000045">
        <property type="entry name" value="2-isopropylmalate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00572">
        <property type="entry name" value="LeuA_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013709">
        <property type="entry name" value="2-isopropylmalate_synth_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005668">
        <property type="entry name" value="IPM_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054692">
        <property type="entry name" value="LeuA-like_post-cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036230">
        <property type="entry name" value="LeuA_allosteric_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039371">
        <property type="entry name" value="LeuA_N_DRE-TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00970">
        <property type="entry name" value="leuA_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002991">
        <property type="entry name" value="PRK03739.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46911">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46911:SF1">
        <property type="entry name" value="2-ISOPROPYLMALATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22615">
        <property type="entry name" value="IPMS_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08502">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00917">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110921">
        <property type="entry name" value="2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89000">
        <property type="entry name" value="post-HMGL domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00815">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00816">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="11">
        <location>
            <begin position="33"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PCH37821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="797" mass="87546" checksum="7E9EB976DCCB04BF" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J7J3</accession>
    <name>A0A2H3J7J3_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">L-serine ammonia-lyase</fullName>
            <ecNumber evidence="3">4.3.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WOLCODRAFT_96098</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-serine = pyruvate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:19169"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="EC" id="4.3.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the serine/threonine dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.17" evidence="3"/>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH37911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J7J3"/>
    <dbReference type="STRING" id="742152.A0A2H3J7J3"/>
    <dbReference type="OMA" id="KCTIFLP"/>
    <dbReference type="OrthoDB" id="7773036at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004794">
        <property type="term" value="F:threonine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006565">
        <property type="term" value="P:L-serine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:L-threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050147">
        <property type="entry name" value="Ser/Thr_Dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078:SF2">
        <property type="entry name" value="CATABOLIC L-SERINE_THREONINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078">
        <property type="entry name" value="THREONINE DEHYDRATASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="7">
        <location>
            <begin position="14"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PCH37911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="381" mass="40833" checksum="DB71F8E13CFC1BFD" modified="2018-01-31" version="1">MPDFEHDSGKLWLETPLIYSPHYSARLGSNVYLKLENLQPCHSFKYRGITHFIQDCLHKHGREVHLVIASGGNAGLAAAYAARALGVHCTVYMPNTAGNSTIAFIKAQGAKTVVVGNYYVDAFNAAEEAIKSDPLAVMVPAYDDPLVWEGHGSMIDETARQLPAGTKPDAIFCSVGGGGLLGGVMSGCRAVGWDDVPLVTLETYGCNCFYQTLAVNPGIFATPSSDPPEGVSVVHDTRYDVDVAHLSSLTSRAACLAASSPAAGVVANALKWKGGIKSVCVPDELAMVAALDLAETHKLLVELACSTVLTPAYAPAILDQLMPPKASGEARTVVFIICGGFKVTLKELEEYRQIIDADLRNGKEWDVACNGEKWEIEKWHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J825</accession>
    <name>A0A2H3J825_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pyruvate dehydrogenase X component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WOLCODRAFT_97079</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH38412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="742152.A0A2H3J825"/>
    <dbReference type="OMA" id="AITKFAM"/>
    <dbReference type="OrthoDB" id="537444at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045254">
        <property type="term" value="C:pyruvate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004742">
        <property type="term" value="F:dihydrolipoyllysine-residue acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000010">
        <property type="entry name" value="Acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="entry name" value="E3-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045257">
        <property type="entry name" value="E2/Pdx1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151">
        <property type="entry name" value="DIHYDROLIPOAMIDE ACETYL/SUCCINYL-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151:SF82">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE COMPLEX PROTEIN X COMPONENT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="7" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="5">
        <location>
            <begin position="30"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="6">
        <location>
            <begin position="168"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="115"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="211"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="279"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="128"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="218"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PCH38412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="301" mass="31490" checksum="50F496CF5C24E677" modified="2018-01-31" version="1">MQAASQLSKAAARSLPSRRWMQTTAARLAVTKFTMPAMSPTMTEGGIADWKKKDGEAFSAGDVLLEIETDKATIDVEAQDDGVMGKILVPNGAKNIRVGQLIALLAEEGDDISNLEAPADESAPTPNSESASAAPLQSQPPSSVPDKQQSAPSVPPTRPTLHPESSRPLFPSVLRLLQENSISDADKIKGTGVRGMLTKGDVLAYLGKASGPLGTFKEAPKEDATKPPKKEEPQILDGPALRRLIVGNMLDASIKARAAAVSTPPADFDSIIADYLPPTKAAAAPPAPKPTAGSQYLDGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J8J0</accession>
    <name>A0A2H3J8J0_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_141441</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH32984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J8J0"/>
    <dbReference type="OMA" id="MRIAISH"/>
    <dbReference type="OrthoDB" id="3181669at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="55"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH32984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="546" mass="61140" checksum="24CDDC189A844FCD" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J908</accession>
    <name>A0A2H3J908_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptidase C14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WOLCODRAFT_27735</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C14B family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467843">
        <property type="protein sequence ID" value="PCH35229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J908"/>
    <dbReference type="OMA" id="CNDITAW"/>
    <dbReference type="OrthoDB" id="3223806at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050452">
        <property type="entry name" value="Metacaspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104:SF30">
        <property type="entry name" value="METACASPASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104">
        <property type="entry name" value="METACASPASE-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Peptidase C14 caspase" evidence="5">
        <location>
            <begin position="2"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="140"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="153"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PCH35229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="306" mass="33626" checksum="E9AE60FC513C38C6" modified="2018-01-31" version="1">MELIGTHNDPRLLMDLLTNTFHYDPEHITVLVDDESKPHAWPTRENMVRAMKDLVAGAQPGDHFVFHFSGHGAQVPNLDGTEKSGFDDVIWPVDVVYNEDGSFDNFIKDDEIHQLLVEHVPPGAHFMMVFDCCHSGTAADLPNSSEECPPRTPTSSTSSSFPSAPAVKNIRVRGSHDAPNTAEDRDGPQRKMLQETHTPAKPLSQIDVPSVPALADVTSWAACEDDEVTLGGPRGGVFITAFVNALKKNPFVTHAELLHTVTREIAKITAAINAHLQSADEPYKAPTPELESIEPMEEKYLEPLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JA30</accession>
    <name>A0A2H3JA30_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF659 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_31142</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467960">
        <property type="protein sequence ID" value="PCH39122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JA30"/>
    <dbReference type="STRING" id="742152.A0A2H3JA30"/>
    <dbReference type="OrthoDB" id="2423954at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007021">
        <property type="entry name" value="DUF659"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32166:SF24">
        <property type="entry name" value="F16P17.2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32166">
        <property type="entry name" value="OSJNBA0013A04.12 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04937">
        <property type="entry name" value="DUF659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF659" evidence="1">
        <location>
            <begin position="28"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH39122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="394" mass="44829" checksum="23B480A1D8089F36" modified="2018-01-31" version="1" fragment="single">GRILEEEAQRVVIGMKQQVQGRFAMGQSDGWKNVTRTSLVTSMINVEYSPYLLNAVDISTQAKNAENLLEIVKAEIKYCMEVLETKVVAWCTDSSGESVKMQRLLRIIFPWIVTVACWAHQLNLVVSDYTKLKLPFMLVLDRALEVIKWFNNHSRALGMLKEETKARLGKVYSLVMPVITRWTTHYLSCRRLLLLETPLRTLAVSAKEVLLLCAGDKAESKRKADEIIRTLCSPTFWDELCLIHSHLEPLAVAVNTTQANNARLDTVLLTLGQLYHTFENPQYEADITRVFILAVVLNPYLRTKCFRSGNAAITEASLSAMLGQCYQRMFGKAPDIYLFQAFTDYLHYLSEFSEDHMALEQLKQLAEKVETDVNLVTLWRRLDTGSPNGRNALT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JA81</accession>
    <name>A0A2H3JA81_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_140559</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467887">
        <property type="protein sequence ID" value="PCH36713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JA81"/>
    <dbReference type="OMA" id="RIGPMAW"/>
    <dbReference type="OrthoDB" id="3198848at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH36713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="180" mass="19765" checksum="FCB8260E1446CA06" modified="2018-01-31" version="1">MGRLDTPRRPLPTKPAGKSRSTTPIPSTVITYRYNDKMVYVTPADSYQQAVDFAKQVFPELADVDRHRITFSVSVKPTKDGNHVQIGPMAWQAVAAQLARYEILEVIVNPAVVVEGADDGPPQYADAVAPPSVEKQEKSQFLSSRSPSPCGEEARKRSSSRSPSRSPSRTERVLHALGVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JA89</accession>
    <name>A0A2H3JA89_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Oxidase ustYa</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WOLCODRAFT_110565</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD-104</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ustYa family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467954">
        <property type="protein sequence ID" value="PCH39116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JA89"/>
    <dbReference type="STRING" id="742152.A0A2H3JA89"/>
    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF11">
        <property type="entry name" value="TAT PATHWAY SIGNAL SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PCH39116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="218" mass="24040" checksum="152C23CCBE2C1424" modified="2018-01-31" version="1">MHRSVHKHYVVPVSVVHAGITALLASILLNTAGTLIHGWPTFTDGLRGLTTSTGLPSRLPIVSPPVAMEVIDSERYGMHDDNDWASVIPNGHGFVRLGEGESGAYYAVSMYHQMHCLNSFRKMFNGRNESRADHDGAHALHCLTYLRQMVLCSADITLEPAFSTSNVDGRKTQAAYGTGVAHVCRDWVQAREWVEDNYKSWIDEDRVFVATEASAVNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JAR0</accession>
    <name>A0A2H3JAR0_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_167874</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467976">
        <property type="protein sequence ID" value="PCH39286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JAR0"/>
    <dbReference type="STRING" id="742152.A0A2H3JAR0"/>
    <dbReference type="OMA" id="HTIIADW"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="414"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH39286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="441" mass="48999" checksum="BCEA41F7D89D72FE" modified="2018-01-31" version="1">MTSDSQRAERQRTVHSAQRTILARIDGLPDIIGVLPGTSVEEEAPWSQVGLVAEIKGASHLDPMDSASQRANADLVQKYAYVLRILGCFACIYRFDHASAVASCRFNYIDEHQFISKFFYRLLRPFYSHKIVLNGQDDFSFAVSESFVRALGIPELIDEDLISAFSDSSSYPLWFAAVFPGNLGSGRATIYRRPLPEDRCLTQEDSDSTPPSSWRKGKVHSISNTWSLTPHGQAREDDADNSCMSVEHSGAPDPKSSSSSARDDLPDGLLLERVIIQERYPQTERMNEAVHFDKINAYLKKHNLPNYGLAKILYGEDLGDSCSVHVTISATAKDPKNRPQNERSHMRIVLNTVAESLDKFTLTKQFVQAIRDAITGAICWRIYPVFSIETCRLLMNAVPNTTRTSRCSATCTPTGGRTLKAPTDPTTGVTHPQYTPSSSIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JAV0</accession>
    <name>A0A2H3JAV0_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein BCP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WOLCODRAFT_111218</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in nuclear export, actin cytoskeleton organization and vesicular transport.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the BCP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH33067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JAV0"/>
    <dbReference type="STRING" id="742152.A0A2H3JAV0"/>
    <dbReference type="OMA" id="VKFYRKE"/>
    <dbReference type="OrthoDB" id="27543at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025602">
        <property type="entry name" value="BCP1_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13261">
        <property type="entry name" value="BRCA2 AND CDKN1A INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13261:SF0">
        <property type="entry name" value="BRCA2 AND CDKN1A-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13862">
        <property type="entry name" value="BCCIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028983">
        <property type="entry name" value="BCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR028983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PCH33067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="286" mass="31507" checksum="338CEB31D9C83605" modified="2018-01-31" version="1">MAKRKQQHADGADSDTDAASDRSLVDVDFDFFDPRPDVDYLALKRLAGQLFQADAEALHVHDLADLVLAQPLVGTTVKCDGIDSDPYAVLTVLNMHVHQDRPAIKALAQYALAKSAPDAAFHGALQNLLGPAGLASQNYVGLVFSERLINMPVQIMPHMYRMLAAEIQLAIDDNEPYRFTHLLVFSRVYKLTAEEEAELQGPAPRTKRQKHAVPTQPSPGRVYPFHPEDEHIQKLALHSLDYTFTRAQPREEGGVGLDTGGRMMLIPAARLPELVSTLLDAYPAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JBC8</accession>
    <name>A0A2H3JBC8_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DUF1751-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WOLCODRAFT_135423</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH33974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JBC8"/>
    <dbReference type="STRING" id="742152.A0A2H3JBC8"/>
    <dbReference type="OMA" id="EIHFWEV"/>
    <dbReference type="OrthoDB" id="73612at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1540.10:FF:000004">
        <property type="entry name" value="Transmembrane protein 115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
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        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
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        <lineage>
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            <taxon>Agaricomycotina</taxon>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
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                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
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                <person name="Ohm R.A."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1221748"/>
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            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
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</entry>
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            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Martinez A.T."/>
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                <person name="Yadav J.S."/>
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                <person name="Benoit I."/>
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                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
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                <person name="Ferreira P."/>
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                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
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                <person name="Kumar T.K.A."/>
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                <person name="Lindquist E."/>
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                <person name="Morgenstern I."/>
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                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
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                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
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                <person name="Schmutz J."/>
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        </citation>
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        </source>
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        </location>
    </feature>
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        </location>
    </feature>
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            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH39135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosducin family.</text>
    </comment>
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        <property type="protein sequence ID" value="PCH39515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OMA" id="KGWHDDE"/>
    <dbReference type="OrthoDB" id="70588at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051499">
        <property type="entry name" value="Phosducin-like_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024253">
        <property type="entry name" value="Phosducin_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46052">
        <property type="entry name" value="PHOSDUCIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46052:SF1">
        <property type="entry name" value="PHOSDUCIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02114">
        <property type="entry name" value="Phosducin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosducin" evidence="3">
        <location>
            <begin position="158"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="13"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="250"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="324"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="16"/>
            <end position="30"/>
        </location>
    </feature>
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        <location>
            <begin position="250"/>
            <end position="262"/>
        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="334"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PCH39515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="353" mass="38829" checksum="447BAB10294293AE" modified="2018-01-31" version="1">MYGDIEELVLSGKLFSPPSRSTSPVRSRSPSPTPAQWPTDDADYEYDSDAERRRAIESRIAADAQSESIGMGPGRTGVKGVIRDHAEAAASVRAKRTQEIIALNREMERASLGGKTWAEEERERIAEEEQLEGKASSMVDGRGSRRGPFGHLMEVGVRSFVQAVEEDRSMWVVVHIYDPSLDRCAALDDVLARLARSFPSTKFLRARAGGIGFAATKTSATSRLGVSRSPFGLRHSESRQILVPGRFSSAEDDDELFDDDRSEDGSSNDGWDDDAVDTDVLPTLLVYRGGVLEHTWVRVDWEAKMGVEELLRRHNILRGSEVREGPSVDRAAVDDEDDLDDGELVFGGSDEGS</sequence>
</entry>
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    <accession>A0A2H3JDG3</accession>
    <name>A0A2H3JDG3_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WOLCODRAFT_29645</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Phaeolaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468020">
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    <dbReference type="STRING" id="742152.A0A2H3JDG3"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Auxin_biosynth/cation_transpt"/>
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        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43539">
        <property type="entry name" value="FLAVIN-BINDING MONOOXYGENASE-LIKE PROTEIN (AFU_ORTHOLOGUE AFUA_4G09220)"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR43539:SF68">
        <property type="entry name" value="FLAVIN-BINDING MONOOXYGENASE-LIKE PROTEIN (AFU_ORTHOLOGUE AFUA_4G09220)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FMO-like"/>
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    </dbReference>
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        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
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    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PCH39605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="575" mass="63698" checksum="1E9DB5F647B36640" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JDS8</accession>
    <name>A0A2H3JDS8_WOLCO</name>
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        <submittedName>
            <fullName evidence="3">Ubiquitin-like protein</fullName>
        </submittedName>
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    <organism evidence="3 4">
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        <lineage>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
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                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
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                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
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                <person name="Lindquist E."/>
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                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
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                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
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                <person name="Stenlid J."/>
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                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467832">
        <property type="protein sequence ID" value="PCH34854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Ubl_Smt3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Small ubiquitin-related modifier I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Rad60/SUMO-like_dom"/>
    </dbReference>
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        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10562">
        <property type="entry name" value="SMALL UBIQUITIN-RELATED MODIFIER"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UBIQUITIN_2"/>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="23"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH34854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="100" mass="10924" checksum="219EB00CB3D6A29B" modified="2018-01-31" version="1">MSEAEHHAPADVELKAEDPNAPINIKVTTQTGEEVFFKIKRNTKLSKLQGAYAAKVGKDVSSIRFLYDGNRINDDDTPASLDMEDNDTIDVMVEQVGGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JE61</accession>
    <name>A0A2H3JE61_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="8">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WOLCODRAFT_68220</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="8"/>
    <dbReference type="EMBL" id="KB468053">
        <property type="protein sequence ID" value="PCH40520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="742152.A0A2H3JE61"/>
    <dbReference type="OMA" id="HESXRAG"/>
    <dbReference type="OrthoDB" id="2499463at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF153">
        <property type="entry name" value="RECQ-LIKE DNA HELICASE BLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="345"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="11"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="218"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PCH40520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="400" mass="45196" checksum="79EE80F85B87C928" modified="2018-01-31" version="1">MLYYDWQLDVTEALLLHLDSIVIAGTGSGKTGPFTLILMADETEKKVVIVISPLNELEKDQAARLTQLGLSATSVNAEVFSPKLQMELAEGKFRIILTSPEMCLEHKEFSRLMRTPSFTENICAVAIDEAHCASHWGGNFRKKYAELYKLRAFVPCHVPFLATSATIPPHILNDVMQKLCIHPQSTYFVNRGNDRPNITVAAFRMAGGASNLSALNFTLDGAIEGGSLERTIIFFNDRDTTMRVWSHLRSILPEEICNQIDFLHGFRSQDSHTIVMEKFREGSIKILCATEAAGMGLDIADITRIVQFMVPPSLSVWVQRYGHAVRSGDAGIAILLVEPLRLQPYNVYTMYTWFFIYTIYMYLHMAKYMVYTWYIILSQIANGVPSLRCNRKLKGRTPLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JEA6</accession>
    <name>A0A2H3JEA6_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_81724</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467865">
        <property type="protein sequence ID" value="PCH36008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JEA6"/>
    <dbReference type="STRING" id="742152.A0A2H3JEA6"/>
    <dbReference type="OMA" id="CEGYIRI"/>
    <dbReference type="OrthoDB" id="2437251at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH36008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="308" mass="35770" checksum="30D2FE8A89F76895" modified="2018-01-31" version="1">MDRFDCHGWLHIVIGSQPHEASIQLKHDENHLAYVNTDLPDHWKEYVEEHSRTQTPGEIWCHIVREETHGKSASEVSMPFRSKAVYYYWHVVSRNEWRRANDPLESARRFIEEKGDEYQVRLLDLEEVPETKVLAFEVTDSMKEWADHTQELAMDSTCMSLSESISHQIHVADAQGSGIPLAFLLILMGPNAAGGTKQTVLEGFLRELKKRRVDPEYTLTDKDWSEINVMHAIWPNAKHQLCFWHALRALKQRLTKSKENPAPYDVISAQEEFSFINTDFLPEMQRRTSDLVCTHQLSYCGRVTHMVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JEM7</accession>
    <name>A0A2H3JEM7_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WOLCODRAFT_23199</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH38263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JEM7"/>
    <dbReference type="OMA" id="LYGLCWP"/>
    <dbReference type="OrthoDB" id="419616at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17330">
        <property type="entry name" value="MFS_SLC46_TetA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <source>
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</entry>
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                <person name="Barry K."/>
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</entry>
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            </authorList>
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        </citation>
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        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH35534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="227" mass="24365" checksum="6F8ED57B8CF01C08" modified="2018-01-31" version="1">MHAHHIPDHQHLIASPTSLPLFPASPTSHQDPSRLASPRLAAHRLNDPPSSLQLVGTSYSTLRPLAQRPTPSPPPPSDARRRPRARFGIDILRPLRALPRRAPAAGLLGARSADVTQSDTGAGTLGGVTSAVRPSSAARRSLPRWDSHAGGTAWARCPDGVWRVASSGLGYLLRHTSSLWAYAARAPGARLGLRYSTPSHARAYPSPDAHPRSVAQDPTFKRYEIIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JH46</accession>
    <name>A0A2H3JH46_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acid protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WOLCODRAFT_141137</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467965">
        <property type="protein sequence ID" value="PCH39173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JH46"/>
    <dbReference type="STRING" id="742152.A0A2H3JH46"/>
    <dbReference type="OMA" id="YWGINVT"/>
    <dbReference type="OrthoDB" id="660550at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013897638" evidence="5">
        <location>
            <begin position="21"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="6">
        <location>
            <begin position="79"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PCH39173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="406" mass="42878" checksum="B269C72CE394D036" modified="2018-01-31" version="1">MAVISLRTLVVLAIASVSVANPVTTNAVTKLALDPVKGRTGAYMHGAPDADRARAQLHKSRGSGGATTIPATNLAYVQYTASIGVGSPATYYNLVVDTGSSNTFVGTGKKYVKTKTSIPTGQEVNVTYGSGYFSGYEYLDQVTIASGLVITNQSIGDALEYADFEGVDGIIGVGPVDLTLDTLYPDVNAQIPTVMNNALEQKLISTEVLGVSFAPADSYSDTNGALTFGGIDDSLYIGEITYTPVTATEPAGYYWGINVTGATYGTTTVIPGSYAGIVDTGTTLIYIADNWYSTYQESIPGAYYDSNDTGLIVIPESSVASLENFTFQIGGVEHVLDPAAQLLPQDQNTAWGGKPGLQYGYIGPLGSNSGEGLDFIIGQKFMERFYAVFDTANERVGFAYTDHTFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JHJ2</accession>
    <name>A0A2H3JHJ2_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_24685</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH41351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JHJ2"/>
    <dbReference type="STRING" id="742152.A0A2H3JHJ2"/>
    <dbReference type="OMA" id="YMTGTDF"/>
    <dbReference type="OrthoDB" id="417891at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005559">
        <property type="entry name" value="PRK07231.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (AFU_ORTHOLOGUE AFUA_6G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180:SF63">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03520)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH41351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="282" mass="30459" checksum="EAB8C8ED6390C5F9" modified="2018-01-31" version="1">MPGRLQHKVALITGAGSGIGLESSLLFAQEGANIALVDVNAQAVERTHKLIAERYPNVKSIPITADVSKEQNVKDMVQKTVDAFGRLDVMFNNAGIMHPEDDNALNTEERIWDLTMNINVKGVWWGCKYAILAMRQNPTDESKGLHTGGSIINTASFVALMGAATPQLAYTASKGAVLSMTRELAMVHAREGIRINSICPGPLKTPLLMDFLNTQEKKDRRMVHLPMGRFGEAIEVARGALFLASDDSSYMTGTDFKVDGGLSSCYVTPLGEPALSPPSSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JHY9</accession>
    <name>A0A2H3JHY9_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ARM repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_143759</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
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                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="3 6"/>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH38789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="742152.A0A2H3JJ40"/>
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    <dbReference type="OrthoDB" id="47059at2759"/>
    <dbReference type="UniPathway" id="UPA00696"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000495">
        <property type="entry name" value="Periplasmic beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019800">
        <property type="entry name" value="Glyco_hydro_3_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037524">
        <property type="entry name" value="PA14/GLEYA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011658">
        <property type="entry name" value="PA14_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF27">
        <property type="entry name" value="BETA-GLUCOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07691">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00758">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00775">
        <property type="entry name" value="GLYCOSYL_HYDROL_F3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51820">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PA14" evidence="7">
        <location>
            <begin position="409"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PCH38789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="852" mass="93881" checksum="67C5C4BA44E3B77E" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JJ52</accession>
    <name>A0A2H3JJ52_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Helicase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WOLCODRAFT_84760</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467943">
        <property type="protein sequence ID" value="PCH38799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="742152.A0A2H3JJ52"/>
    <dbReference type="OMA" id="RITHGQS"/>
    <dbReference type="OrthoDB" id="2803695at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="4">
        <location>
            <begin position="173"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PCH38799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="331" mass="37128" checksum="24D09220A74F3AE1" modified="2018-01-31" version="1" fragment="single">KESGKAEEILSRITHGQSLSVSSEYLKAMNEFMDEMRTAFHGHIIRRTLKSTDWEDNPISGLRPYREHLIIRSLFEFEEKALEDVKPGISCDNDDAAKEAGDLFIAKGKNFYLNIRKSLTHPACHSSADFLEGNLPISSKIDGLIKILKHHLAMDNMSPMKYDSNEKDLVPDNEKTVLDRAPESEPDKIVIYVAFPSNLPTLTEFLEAEGIKFFTYTGSNSMKVRSDTLKAFHKAGRDDPRVLIMSGAGAVGLNIAFANILIIMDTLWSAQEDAQLIGRVWRHPQPKLVEVYRLIAAGTPDVFLNNISFDKGYMHGSFANTSETLRKSPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JJD5</accession>
    <name>A0A2H3JJD5_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sphingomyelin phosphodiesterase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WOLCODRAFT_101879</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Converts sphingomyelin to ceramide.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acid sphingomyelinase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468124">
        <property type="protein sequence ID" value="PCH42292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JJD5"/>
    <dbReference type="STRING" id="742152.A0A2H3JJD5"/>
    <dbReference type="OMA" id="WIIAHLP"/>
    <dbReference type="OrthoDB" id="282973at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004767">
        <property type="term" value="F:sphingomyelin phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006685">
        <property type="term" value="P:sphingomyelin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00842">
        <property type="entry name" value="MPP_ASMase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041805">
        <property type="entry name" value="ASMase/PPN1_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011160">
        <property type="entry name" value="Sphingomy_PDE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340:SF27">
        <property type="entry name" value="ACL091CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340">
        <property type="entry name" value="SPHINGOMYELIN PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000948">
        <property type="entry name" value="Sphingomy_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013884198" description="Sphingomyelin phosphodiesterase" evidence="6">
        <location>
            <begin position="24"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="7">
        <location>
            <begin position="235"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="321"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="321"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="362"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="476"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="513"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="515"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="126"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="257"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="263"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="652"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000948-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000948-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PCH42292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="677" mass="74520" checksum="4CF57478B2072036" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JJX1</accession>
    <name>A0A2H3JJX1_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_140325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467876">
        <property type="protein sequence ID" value="PCH36307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
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    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
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        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="19"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH36307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="316" mass="35248" checksum="327D32E134670643" modified="2018-01-31" version="1">MQAGVEGHVAYLPFSDVLADVILRSSNGVSFRVHSRILCEASPTCFEGMFSIPPPKDAQNDTLDGLPFIDCTEDDSTLDKLLRICYPTTDPSFQRLNDVEAVMEAATKYDMEHAQEYCMKELFQARFLDTNPISVFAVVYEFDMISEAKVAAKATLHLDSAAFVRCMQTSPIRMLPSAIVDLVGYRDACGRAVTRALQRDSWNKVVLGQWHSSPLGYIPCDECDDYSGFSEYVDGLDADAYHAFACQLLNPPEAPIRPKDLADQLSRAARRDFESSFKDNCSTCQQALLREVTSFSEHVARTIDACINKVPFILSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JKD9</accession>
    <name>A0A2H3JKD9_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_56529</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467876">
        <property type="protein sequence ID" value="PCH36467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JKD9"/>
    <dbReference type="STRING" id="742152.A0A2H3JKD9"/>
    <dbReference type="OMA" id="VEWEMNR"/>
    <dbReference type="OrthoDB" id="2745096at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH36467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="130" mass="15451" checksum="44396D34A4F91D46" modified="2018-01-31" version="1" fragment="single">ILNDWGLCKYKNDMDKVSQSETRSDTWQFMSAALLWSPEMVHKLSDDMESFVHMLDWPTFRYHKTQLSNDSTALQKRVYHLYNDQYKRRSHNNHGGENKMRTGKAPCRAKNNPLYLCFLDSLAELCKEHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JKI4</accession>
    <name>A0A2H3JKI4_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WOLCODRAFT_163984</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB468124">
        <property type="protein sequence ID" value="PCH42700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JKI4"/>
    <dbReference type="STRING" id="742152.A0A2H3JKI4"/>
    <dbReference type="OMA" id="MGTAFMP"/>
    <dbReference type="OrthoDB" id="5086884at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF9">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="362"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="402"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="425"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="452"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="566"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="50"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="602"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="612"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PCH42700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="624" mass="66224" checksum="4B5E26D26DD0A03C" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JKP1</accession>
    <name>A0A2H3JKP1_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_164008</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468135">
        <property type="protein sequence ID" value="PCH42760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JKP1"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH42760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="212" mass="24369" checksum="C10A78A4E79D05D5" modified="2018-01-31" version="1">MTILCFNAYSALRAWYVRTMEADLQQENPSESCTNPGQFYDYIFLSVYEHATTTDTQAARDTVKDIDALMLSIGAKYPRAPWTVLQTIPFRCRISPYLNLTAIGSMLQHRPMNCPKFLLNYNDPMTKYIRDLPWSNILVMFKFMHCLAYYIRIERVKEKTLGEVAEEISVAFEKYWRILGGDTLDQLGNVVEDGRDGRKASHTSTQLTVGLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JL91</accession>
    <name>A0A2H3JL91_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_73957</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468135">
        <property type="protein sequence ID" value="PCH42976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JL91"/>
    <dbReference type="OMA" id="FIEWPFF"/>
    <dbReference type="OrthoDB" id="3263941at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040410">
        <property type="entry name" value="UPF0658_Golgi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34391:SF2">
        <property type="entry name" value="TRP C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34391">
        <property type="entry name" value="UPF0658 GOLGI APPARATUS MEMBRANE PROTEIN C1952.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <begin position="12"/>
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        </location>
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        </location>
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        </location>
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        </location>
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            <end position="294"/>
        </location>
    </feature>
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        <location>
            <begin position="306"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="336"/>
            <end position="355"/>
        </location>
    </feature>
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            <end position="391"/>
        </location>
    </feature>
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            <end position="457"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH42976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="466" mass="52401" checksum="856772F53703E728" modified="2018-01-31" version="1" fragment="single">YIRITVSRLGILFLLLTFAHCFAHGGLQIALLRSDVNLRSLLMHITSAADVPSAQIPWLDHLGHGQYDLKLCTRIPLRGINTTNSCTSLFHTGGFSNAAAYDIDSVDTIYDDGSRMVLLSGTCSRTMLWAQNLVGSFGEEDVALLSAQFWLLLISSVAVSYRSIPQIVAVLCVRLIATMWSAYSIWRAMHYKVLFQLLYMGPGAPCQLDFFTSFFTIRTSLAIPSLILNITALAFEGYMGRKLIKAFDALIFHRVAPPGAVLKIYRYFLAIFVLLQLDVFFLLSMIGLWISWLINGLGDLTVNKTLYEALFITTMITLLPWLATGWFAVRREMKTLMAVFIFMSFVFLALLATMFRTDVFAWTFLQWPFFACLTCISFILLFATGLFGIICRLNFGKGLAQYLHVEAVLAEANFAPELFENDTRQLKISDEKSMHRPSTALPTEKYDKRGLPDDDASPVIVIERLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <location>
            <position position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH42821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="185" mass="21152" checksum="12840081958046A7" modified="2018-01-31" version="1" fragment="single">MIVQKYMPYQNIPNAPGKMTEEICKLGMRLFPFTLHSFELAMSMYDWMMASFTQMVIMKIFQYMGIEKMPFPLDQPSIATEIFESNWGTYILSNPDYMNSFMMEPASSVDEVKAQLDAVAPKLHEFSNVQNHLFAVVVQALLHTSPISMPRLFSGQVNIYQLGMDHFGIEFLKCPLNKGPTTEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
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        <lineage>
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    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
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                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
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    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF3">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="17"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="5">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PCH36977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="283" mass="31105" checksum="2E60D6F813802248" modified="2018-01-31" version="1">MPWGSIELNDGTMIPDIAYGTWKLGNGDVTIGRVKQALSVGFTHIDTAQIYRNEKEAGEALRASGLAREDVYITTKYSGRADIDTSIRNSCEYTMWTCTSYTAPDLAVPDIPTLWAKMEQIKANELAKYESSHESIQTLTQSLTYCRSIGVSNFNVQELTTLLTSAKVKPVVNQILFHPYVLRRQAPIVAFGAQHGIVTEAYSVLIPITRQTGGPLDKPLKEIADRLGAQPEQVLLAWAKKKGVVSVTSSTRKERMEGYLKAGDLELTAEDIAAIDTAGLSRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JM25</accession>
    <name>A0A2H3JM25_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_152598</name>
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    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468124">
        <property type="protein sequence ID" value="PCH42565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JM25"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="140"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="51"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="8"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="152"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH42565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="165" mass="18174" checksum="049AF13BA8ABAA64" modified="2018-01-31" version="1">MDIDNTRSAASSDNDMSTDTSSDSDAMDIDAPPSSPGRVDRIKLAWYCDANKRLNDENVRLMAKVAGMEKAAKEKSDKLQGRFDELKRVVVNAFKNIERKNARLQAQVTALEAKTIRLERESRAMKVLLARCMHAECLPPYPGPPALPQDTAAAPPSSNPPAYRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JM82</accession>
    <name>A0A2H3JM82_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cofilin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Actin-depolymerizing factor 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WOLCODRAFT_23705</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin-binding proteins ADF family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468053">
        <property type="protein sequence ID" value="PCH39909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JM82"/>
    <dbReference type="STRING" id="742152.A0A2H3JM82"/>
    <dbReference type="OMA" id="ITFYSWS"/>
    <dbReference type="OrthoDB" id="10249245at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016363">
        <property type="term" value="C:nuclear matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030042">
        <property type="term" value="P:actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11286">
        <property type="entry name" value="ADF_cofilin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017904">
        <property type="entry name" value="ADF/Cofilin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11913">
        <property type="entry name" value="COFILIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADF-H" evidence="6">
        <location>
            <begin position="5"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PCH39909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="139" mass="15610" checksum="5257B6FA89C450A7" modified="2018-01-31" version="1">MSQSGVGVSQNCINAYQSLKLGKKIKYIIFTLNSDNTEIVVEKESESTNYDEFLADLPEAEPRWAVYDFEFEKEGAGKRNKITFFSWSPDDSKIKQKMLFASSKDALRRSLVGIAAEIQGTDYSEVAYESVLDKVSRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JNB7</accession>
    <name>A0A2H3JNB7_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Condensation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_138512</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468146">
        <property type="protein sequence ID" value="PCH43670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JNB7"/>
    <dbReference type="STRING" id="742152.A0A2H3JNB7"/>
    <dbReference type="OMA" id="LHEMMEL"/>
    <dbReference type="OrthoDB" id="2775229at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42034">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42034:SF1">
        <property type="entry name" value="CONDENSATION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH43670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="494" mass="54211" checksum="B2318913A973F2AA" modified="2018-01-31" version="1">MQSQSVLPYSDLTISRPLGIVEYLWLSSRGMRGFMDMFTVVALDCSDRHVTHKDVETAFSIIRLRHPLLGSRLSRTSSSPLPELMYAVPMTDAHAIREARANLEFGTFQDRDTAMSTLRERGIKSPPSTAIDVRSSMSFIVWLEGIGSSSGQHVIGLLIPHFITDARRKLGVLHEMMELLAAPERLQSELAQLCATAAVSIQLPAPLDSKVPDLSACSADELRKAREVFDELTKFSKMPRSGLVPDGTPDEDKYAGRALHHTFSPDQTTSILRACKVLGVTITSLILSAMAFATLPRKDAQRSGDQTTSNSDDDVRHFHATVLVDLSTRLPEPPSGGDNVTLWVGSSPVFMQTPGSSTAQHEGIDAIWAVAKQCRERHAAYLQSPYFWHFNELYASMTMAPWNPVPEGKAFLPAFSSLGDCSNLLSSSNGIDIVDIAFAGTVSPEAVVAVAWTYKGMLNYQLRHNASRTTATLIDPFFQRVVDILMKASLEDVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JNB9</accession>
    <name>A0A2H3JNB9_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1746 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WOLCODRAFT_122400</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD-104</strain>
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</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JNV0</accession>
    <name>A0A2H3JNV0_WOLCO</name>
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            <fullName evidence="3">Endoribonuclease YSH1</fullName>
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            <fullName evidence="9 11">mRNA 3'-end-processing protein YSH1</fullName>
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        <name evidence="16" type="ORF">WOLCODRAFT_104322</name>
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        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
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        </lineage>
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    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="16 17">MD-104</strain>
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        <text evidence="2">Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.</text>
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        <property type="entry name" value="CPSF73-100_C"/>
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        <property type="entry name" value="Lactamase_B_6"/>
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    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
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        <source>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
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</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JNW0</accession>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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        <name evidence="1" type="ORF">WOLCODRAFT_153923</name>
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    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Agaricomycetes</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="79" mass="8672" checksum="2647B5B2008106BD" modified="2018-01-31" version="1">MRMSMLSVFDADHRSWRRVRVRDVLHPAVIVRPLRVPSFVALTVDGNISKLGCLGVPAGAQRAPDSEFGWDVDAASALK</sequence>
</entry>
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        <name type="common">Brown rot fungus</name>
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            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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        </lineage>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
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                <person name="Lucas S."/>
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                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
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                <person name="Sabat G."/>
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                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
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            <dbReference type="DOI" id="10.1126/science.1221748"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10 11">MD-104</strain>
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        <reaction evidence="6">
            <text>Successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1-&gt;3)-beta-D-glucans, releasing alpha-glucose.</text>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="GH"/>
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        <property type="entry name" value="Glycosyl_hydrolase_5"/>
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        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
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    </evidence>
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    </evidence>
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    </evidence>
    <sequence length="729" mass="78057" checksum="8CBA9E57D2625F9C" modified="2018-01-31" version="1"> </sequence>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Martinez A.T."/>
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                <person name="Yadav J.S."/>
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                <person name="Benoit I."/>
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                <person name="Ferreira P."/>
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                <person name="Glotzer D."/>
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                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
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                <person name="Lundell T."/>
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                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
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                <person name="St John F."/>
                <person name="Stenlid J."/>
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                <person name="Syed K."/>
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                <person name="Wiebenga A."/>
                <person name="Young D."/>
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                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </feature>
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            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <end position="300"/>
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    </feature>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="348"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH40639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="368" mass="39948" checksum="E3B1387DD025DCDD" modified="2018-01-31" version="1">MPRAAQIACSGNDPRACRPWDVFRELLKQGNYTRPDSPPPPAGGKAWTEWASALYETLTEEEKAELQELARKRHHEMMHTPAEMEAKLGAEEYERARRAAGMETAIRLTAEHWEKQTGWVGTIMMTGLDENGYVTTYTHNTGSNHANQDFEQTLREEAGLTLGRIRGTLFRFGQDIFDPAPSMRDVPAAGIETSSLPLTDSGVTALMEEEADRRSLLSTSSPVPSPAALGTETPEIHAAPPPTVVLAPLETEGATESASSPVPSPELEAAPVLSPTPSRLPTALVMVAQQSHAEPSSGTALVQVEPEPVSVPSLTSSVTPVERSAVASSTIPINSPPRLKRKKMASAKLRDPNRDEESEGRPRKARRR</sequence>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Benoit I."/>
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                <person name="de Vries R.P."/>
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                <person name="Nagy L.G."/>
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                <person name="Rokas A."/>
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                <person name="Sabat G."/>
                <person name="Salamov A."/>
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                <person name="Stenlid J."/>
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                <person name="Sun S."/>
                <person name="Syed K."/>
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                <person name="Wiebenga A."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH39718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="194" mass="21510" checksum="2AB97BB8E82717F3" modified="2018-01-31" version="1">MPCISNKHTKGSSTAPYAKPAKRSLIDRIQSPPAEESLTYTHPVKDDYTGKLHLWEIPAHLLKHIAEAGKLKPCPPKPAPLTKRVWTEEEKLRASISTMEFQLECKKLNKLIAAHDKLNKRIAAKKPKLTSLALHVPVLIARPPVLAIHSTLDPSLIFGKKKPLAAADHVIPMLEGTLTRLAPQPDVENYEEAL</sequence>
</entry>
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        <lineage>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">MD-104</strain>
        </source>
    </reference>
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        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="pH-response_reg_palI/RIM9"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
    </feature>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="171" mass="18126" checksum="B116B0CCBF87E703" modified="2018-01-31" version="1" fragment="single">MLAAVTPFVAFLLLLLSAPIIKAVYLVAHATSLVDASGSVWFGVWGYCISAVDVSTILAALHATDLNVSRTISAVLVLHPIACGFTFLALLASFFMRPDRRPSRGAAVLTLITGPLAALNSTVVFVRHRVRSKSDGVLTLNAGRDTFLIWVWMVLGATVALWFALVGACAG</sequence>
</entry>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
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                <person name="Ferreira P."/>
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                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
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                <person name="Wiebenga A."/>
                <person name="Young D."/>
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                <person name="Eastwood D.C."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="CDP-alcohol_PTase-I"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CAT EYE SYNDROME CRITICAL REGION PROTEIN 5"/>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="PCH43585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="1">Uncharacterized protein</fullName>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
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                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
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                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
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    <dbReference type="AlphaFoldDB" id="A0A2H3JQ67"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="EMBL" id="PCH44051.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JQK0</accession>
    <name>A0A2H3JQK0_WOLCO</name>
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        <recommendedName>
            <fullName evidence="6">Clathrin heavy chain</fullName>
        </recommendedName>
    </protein>
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        <name evidence="10" type="ORF">WOLCODRAFT_76210</name>
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    <organism evidence="10 11">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD-104</strain>
        </source>
    </reference>
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        <text evidence="6">Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.</text>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasmic vesicle membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <location evidence="6">Coated pit</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the clathrin heavy chain family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:actin cortical patch"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="GOC"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.110">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055358">
        <property type="entry name" value="CHCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR016025">
        <property type="entry name" value="Clathrin_H-chain_N"/>
    </dbReference>
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        <property type="entry name" value="Clathrin_H-chain_propeller_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016341">
        <property type="entry name" value="Clathrin_heavy_chain"/>
    </dbReference>
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        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10292:SF1">
        <property type="entry name" value="CLATHRIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10292">
        <property type="entry name" value="CLATHRIN HEAVY CHAIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00637">
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        <property type="match status" value="7"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Clathrin_H_link"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Clathrin_propel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002290">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00299">
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        <property type="match status" value="7"/>
    </dbReference>
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        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50989">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0168">Coated pit</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 6" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="3 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Clathrin heavy chain linker core motif" evidence="9">
        <location>
            <begin position="336"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="543"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="692"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="839"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
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            <end position="1130"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
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            <end position="1275"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="1280"/>
            <end position="1426"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="1429"/>
            <end position="1572"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="1609"/>
            <end position="1639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PCH44416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="1659" mass="188255" checksum="F557BA1F58A2B080" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JR12</accession>
    <name>A0A2H3JR12_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">PRP1 splicing factor N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WOLCODRAFT_136715</name>
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    <organism evidence="9 10">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Phaeolaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD-104</strain>
        </source>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010491">
        <property type="entry name" value="PRP1_N"/>
    </dbReference>
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        <property type="entry name" value="Syf1-like"/>
    </dbReference>
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        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
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        <property type="entry name" value="PRE-MRNA SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 6"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF13181">
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    </dbReference>
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        <property type="match status" value="13"/>
    </dbReference>
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    </evidence>
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        <source>
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        <source>
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    </evidence>
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        <source>
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        <source>
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        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF06424"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH40188.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="922" mass="102835" checksum="18C080090C1A4553" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JRF0</accession>
    <name>A0A2H3JRF0_WOLCO</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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        <name evidence="1" type="ORF">WOLCODRAFT_136348</name>
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        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="PCH38577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JRF0"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="EMBL" id="PCH38577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="100" mass="11538" checksum="699093D933579968" modified="2018-01-31" version="1">MAESVYDEASGGTKDQHFGDHHHEYELCTMQLSFSDCWMMLHNHAHRDRRDVLGVLTPTVCTYRPSQSSARRRSAFRNGSTLLGLRYSYWISLQSVRGET</sequence>
</entry>
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    <accession>A0A2H3JRH8</accession>
    <name>A0A2H3JRH8_WOLCO</name>
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        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
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        <name evidence="5" type="ORF">WOLCODRAFT_118862</name>
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        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
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        <lineage>
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            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
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                <person name="Lindquist E."/>
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                <person name="Lundell T."/>
                <person name="Martin R."/>
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                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
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                <person name="Patyshakuliyeva A."/>
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                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
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                <person name="Stenlid J."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD-104</strain>
        </source>
    </reference>
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        <property type="component" value="Unassembled WGS sequence"/>
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    </dbReference>
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        <property type="term" value="P:DNA-templated transcription"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AtrR-like"/>
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        <property type="entry name" value="XnlR_reg_dom"/>
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    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF1">
        <property type="entry name" value="MISCELLANEOUS ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
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            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="3">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="778"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="789"/>
            <end position="806"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PCH41399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="989" mass="108989" checksum="F811E7A7334981AA" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JSP7</accession>
    <name>A0A2H3JSP7_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WOLCODRAFT_165527</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Phaeolaceae</taxon>
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    </organism>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
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                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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        </citation>
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    </evidence>
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</entry>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Barry K."/>
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                <person name="Spatafora J.W."/>
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                <person name="Benoit I."/>
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                <person name="Ferreira P."/>
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                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
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                <person name="Heitman J."/>
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                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
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                <person name="Nagy L.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="116" mass="12748" checksum="B5C6078223FFA192" modified="2018-01-31" version="1">MLRAVSLLGDWPTLERPWPAIHTQKPVSGRVLDVIHIRGAQSEMRPMPDVLFISSTHACIAAQGPAQCVLARRAPRATGTLPLGARQSSLPQGRAPHAVFSAIARQLTHHWPRRSR</sequence>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
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                <person name="Benoit I."/>
                <person name="Boyd A."/>
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                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
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                <person name="Gaskell J."/>
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                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
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                <person name="Kohler A."/>
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                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
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                <person name="Ling A."/>
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                <person name="Lundell T."/>
                <person name="Martin R."/>
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                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
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                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
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            <dbReference type="EMBL" id="PCH39407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
    </evidence>
    <sequence length="75" mass="8138" checksum="4E8CEFB6DCAF400D" modified="2018-01-31" version="1">MSVSGKLASMVLSATGSVVSPPPSVSGSVSMLSVECPSYVVHRDGVTRMMWVSPRRRRRPLTDVVWHDILLGNLT</sequence>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
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                <person name="Benoit I."/>
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                <person name="Hori C."/>
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                <person name="Jurgens J.A."/>
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                <person name="Kumar T.K.A."/>
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                <person name="Nagy L.G."/>
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                <person name="Ohm R.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
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        <property type="entry name" value="Protein_HGH1_N"/>
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        <property type="entry name" value="PROTEIN HGH1 HOMOLOG"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR13387:SF9">
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    <dbReference type="Pfam" id="PF04063">
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            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04063"/>
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</entry>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
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                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
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                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
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                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
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</entry>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
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        </source>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="453" mass="50019" checksum="F1605EA4B303FDA5" modified="2018-01-31" version="1">MESRELIDAQFDRAVEIVQSLPKNGPIQTGYEEKLTMYSLYKQATVGNVQSPRPSVWDMLGRAKWDAWAKHRDLDPYEAKWLYVDALLKVLRRYSDKTVAMDLVRELESYSGDPSNLVMSGSMSRSRASTSSSSTASDDHLHQPRAAPPFSSRTLEPRLEEFSADEDEEHDDMPPVPLVPPVYAPSHPTRPQSSMSSRRYRTPTAGSLVLSSPPVPATQPLPEFATESAYAEPSAASHPPAGYPPSGSSYQGYTRASTTDLPAPYTHPSASAYHTSSQQQQQRRPYGAYPGAARPPSRPTLERAIENMQAAVAALTERIDTLEEGALRSTTTLSAQSRTSPRRGVSPGEDGSAGWDVDDMGLWSIVLTPLARAAAMLKFISSFLGRGHGRSPALVILRRLFLDISFLLCVLAVARMVWRRSGMRRREVLAALRGLWWAVVGRKPPRMLVERSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
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                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
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                <person name="Larrondo L.F."/>
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                <person name="Ling A."/>
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                <person name="Nagy L.G."/>
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                <person name="Ohm R.A."/>
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            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
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</entry>
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            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Nagy L.G."/>
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                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JYE7</accession>
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            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD-104</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468146">
        <property type="protein sequence ID" value="PCH43929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JYE7"/>
    <dbReference type="STRING" id="742152.A0A2H3JYE7"/>
    <dbReference type="OMA" id="LHPRIMT"/>
    <dbReference type="OrthoDB" id="10052040at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03342">
        <property type="entry name" value="TCP1_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000038">
        <property type="entry name" value="Chaperonin containing TCP1 subunit 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000058">
        <property type="entry name" value="T-complex protein 1 subunit zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.260.10:FF:000017">
        <property type="entry name" value="T-complex protein 1 subunit zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000004">
        <property type="entry name" value="T-complex protein 1 subunit zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012722">
        <property type="entry name" value="Chap_CCT_zeta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02347">
        <property type="entry name" value="chap_CCT_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PCH43929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="552" mass="60032" checksum="9C0ED607E0A82792" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JZB6</accession>
    <name>A0A2H3JZB6_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Elongation factor 1-gamma</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WOLCODRAFT_73689</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468135">
        <property type="protein sequence ID" value="PCH43228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JZB6"/>
    <dbReference type="STRING" id="742152.A0A2H3JZB6"/>
    <dbReference type="OMA" id="TQYFSWT"/>
    <dbReference type="OrthoDB" id="249703at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03181">
        <property type="entry name" value="GST_C_EF1Bgamma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03044">
        <property type="entry name" value="GST_N_EF1Bgamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000006">
        <property type="entry name" value="Elongation factor 1 gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000142">
        <property type="entry name" value="Elongation factor 1 gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1010:FF:000001">
        <property type="entry name" value="Elongation factor 1-gamma 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1010">
        <property type="entry name" value="Translation elongation factor EF1B, gamma chain, conserved domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050802">
        <property type="entry name" value="EF-GSTs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001662">
        <property type="entry name" value="EF1B_G_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036433">
        <property type="entry name" value="EF1B_G_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43986">
        <property type="entry name" value="ELONGATION FACTOR 1-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43986:SF1">
        <property type="entry name" value="ELONGATION FACTOR 1-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00647">
        <property type="entry name" value="EF1G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01183">
        <property type="entry name" value="EF1G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89942">
        <property type="entry name" value="eEF1-gamma domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50040">
        <property type="entry name" value="EF1G_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3 8" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="2 3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="6">
        <location>
            <begin position="3"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="7">
        <location>
            <begin position="90"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="EF-1-gamma C-terminal" evidence="5">
        <location>
            <begin position="263"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="218"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="238"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="255"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PCH43228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
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                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">MD-104</strain>
        </source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
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                <person name="Lundell T."/>
                <person name="Martin R."/>
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                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
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                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
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                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
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                <person name="Stenlid J."/>
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                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
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                <person name="Eastwood D.C."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">MD-104</strain>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH44497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="273" mass="31719" checksum="47C594BADEA77C17" modified="2018-01-31" version="1">MPERGPKPSYQGENGFVDPLRLRVQGQVQLPNLHAKPSSTDEAEVGRHSRQVHDAVERRRFAEDVLRLKGSYFLGVAAAQEMEKRKDTAASIKESIVDLKTKHSEELQTLYDWQAEDYLEEMQQRCFSKDDSIASPEIDSLYSKLHKSRTELVETFDDNVSMFRYGHHRALSGLMKHHAALVKGEEKQRRERDKQFPADIAAYRAITNKDVQLRIARFLTADSIARDRMQDEFGWVWRQVQSLVDEYNRNSDFKTEIQGLIRGVEARDPRRRT</sequence>
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<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
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        </lineage>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
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            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ribose-phosphate pyrophosphokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.1" evidence="4"/>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH33655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3IW59"/>
    <dbReference type="STRING" id="742152.A0A2H3IW59"/>
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    <dbReference type="OrthoDB" id="413572at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002189">
        <property type="term" value="C:ribose phosphate diphosphokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009156">
        <property type="term" value="P:ribonucleoside monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000001">
        <property type="entry name" value="Ribose-phosphate pyrophosphokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000005">
        <property type="entry name" value="Ribose-phosphate pyrophosphokinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000842">
        <property type="entry name" value="PRib_PP_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002320">
        <property type="entry name" value="PRK01259.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210:SF32">
        <property type="entry name" value="RIBOSE-PHOSPHATE PYROPHOSPHOKINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01400">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00114">
        <property type="entry name" value="PRPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribose-phosphate pyrophosphokinase N-terminal" evidence="14">
        <location>
            <begin position="7"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PCH33655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="320" mass="34879" checksum="3E9BE4A8725463EF" modified="2018-01-31" version="1">MFTGNGIKIFTGTSHPELAEIVTRRLGIPLSKAEVTKSGIGETNVRIAESVREDDVYIINTGCGQVNTALMELCIMVHACKIASAKRITAILPLFPYARQDKKDKSRAPITAKLVANMIQKSGCDHVITMDLHASQIQGFFDVPVDKLFAEPSAIQYIRTNFDLSQIVIVSPDAGGAKRATSIADRLGVDFALFHKERKKANEVSRMILVGRVKGKIAILVDDMADTCGTLCLAAQHLSEAGATRVFGLVTHGILSGNALKTIEESALEKLIVTNTLPQQENMEKCTKIEVIDIGNVLAEVIRRSHYGESVSKLFDEVPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IW68</accession>
    <name>A0A2H3IW68_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_141747</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH33665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3IW68"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH33665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="269" mass="30565" checksum="47DBDD826E729CFC" modified="2018-01-31" version="1">MALSGLTKGQRTADNGDEAGSLDEDSFEEWHPRGPPTKPTSVKLLKPVKQDKKQSSVKDQDKKQVKKPQNNGSTGQVEGESAEPESIHGRKSTCFMMYGRYDADKGVDLGYYVYTMASPDFTRTSRATRDCVLRGELGWKTSYYPVNDRAGQTLRCTMAYCQHNPQKLIQPLRNVSRVNILRYIWLVVVLLLTCIRESPRANQLSDAILEDDTRSALNIEADTDHRVARSRKEKPTNCYRPDWISALRETEMIRSRLALMGHFYVMIAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IWC3</accession>
    <name>A0A2H3IWC3_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WOLCODRAFT_113455</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH34256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3IWC3"/>
    <dbReference type="STRING" id="742152.A0A2H3IWC3"/>
    <dbReference type="OMA" id="AGCLEEW"/>
    <dbReference type="OrthoDB" id="1933717at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF37">
        <property type="entry name" value="CLAVALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PCH34256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="291" mass="31301" checksum="22EA01BA4215DCCC" modified="2018-01-31" version="1">MALPSSDVNLIPADRHDTYPSIDPTKANLAGRVVLITGASRGLGKGTAIAFAKAGVSGLALLARSDMSDVEAACMAAQRPGQALRVLALAADTTNKAQVAAAAERVRETFGRLDVLVNNAGIIESSMKLIGETDSDEWWNVFRVNVLGTYQVTRACLPLLIGCGGDKMVFNLSSIAAHLLGKYNSAYRMTKLAICRFTEQLALEYSPMGLISIAIHPGFVATSMADSMPPGTKHILVDKPELAGDTLVWLAKEKREWLSGRFVNCQWDMDELLLKKDVILSGSLLTVKLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IWD9</accession>
    <name>A0A2H3IWD9_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Membrane-associated glutathione metabolism protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WOLCODRAFT_135475</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH34051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3IWD9"/>
    <dbReference type="STRING" id="742152.A0A2H3IWD9"/>
    <dbReference type="OMA" id="VIFNCIQ"/>
    <dbReference type="OrthoDB" id="410651at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.550">
        <property type="entry name" value="Membrane associated eicosanoid/glutathione metabolism-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050997">
        <property type="entry name" value="MAPEG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023352">
        <property type="entry name" value="MAPEG-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001129">
        <property type="entry name" value="Membr-assoc_MAPEG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10250:SF26">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10250">
        <property type="entry name" value="MICROSOMAL GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01124">
        <property type="entry name" value="MAPEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161084">
        <property type="entry name" value="MAPEG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="122"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PCH34051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="152" mass="16578" checksum="6AEE087525102D7C" modified="2018-01-31" version="1">MSVTIVLSKEYVYPVAAIASTCWLTFWQTIKVGGARKRAGIPYPYVYADKAEVAANQEANVFNCTQRAHQNTLEYFPIVVASTVVASLKHPLIAASLCGLFTASRVVYTIGYSTGDPAKRNLFGSAMFSSLGWLALLGTSAWTVVELFRETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2024-01-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IWV7</accession>
    <name>A0A2H3IWV7_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_15347</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH34480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3IWV7"/>
    <dbReference type="STRING" id="742152.A0A2H3IWV7"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH34480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="317" mass="35961" checksum="FEB40A2B5E203A6A" modified="2018-01-31" version="1">MISLQRFSSIAELHLSRVRFRNLQQFGDLVCALPRLGTLRLRNIMGLESRSDTVALGRRTTVSVLSNFELYFGEYYNAALPALTSWIGAALPNNTLTNISVDGGYSEITQWTTSMNQLLRAAGQSLRSIHIDNMCIRSQERRPQGAPFIPGFIPVTEVPIDRLLNFVHNTHLRSISLDLVYKEGAHRAVFNGWLPWLLSHISSGELTDIEVYIPDLTACNDILARGGMPEICNSVGFSEIDAIISTPQFERLQHVRFLFDLEEVHWWIDGDDIAVDHNIHPIFWTETRRILATKIFNGIREHMPLTHARGILSLERC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IXX4</accession>
    <name>A0A2H3IXX4_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">WOLCODRAFT_139605</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
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    <sequence length="1235" mass="134694" checksum="DBED1AECFBF83587" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IY19</accession>
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            <fullName evidence="3">ENTH-domain-containing protein</fullName>
        </submittedName>
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        <name evidence="3" type="ORF">WOLCODRAFT_139476</name>
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        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Phaeolaceae</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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    <sequence length="505" mass="56988" checksum="C3D7D45B7A71BDE3" modified="2018-01-31" version="1">MSTMQHFGKGVMRVAKNYTKGYSDVQAKVRDATSNDPWGPSGTQMNELAQLSYNQNDFIEIMEMLDKRLNDKGKNWRHVFKSLTVLDYLLHAGSENVVLYFRDNIYVIKTLKEFQYIDEEGRDQGANVRQKAKDITNLLQDEALLRQQRRSRANMRDRMVGGRKIEGDDFNVGDDENAQRRSHSLPARRRTDGDAELQRAIEESKRSLAEEEARKGMMTAEERDIAQAIKLSEEEEAKRAKAIADSNQAALFDDHNQLVSTATANTNNPFPLVDVSGGLQPQFTVQPQFTSFNPYQQQMQQEAMQAEYMRQQQEWMQQQQQLQAQQAAQMQQAQQEEWMRQQQLLAMQQQQQQQMLMAQPTGFGSNNPFAPAGPQTNSVSASPFSQPLTQSPAPQSTAPVFNLQGTYANGGPASSPPPQPPQPSRSAPPQQSPVQAKTRADDQHAHLANLLANRDEGIDTFGNFGQLRFGQQAGRLTGQPTGQSHNPFQQQQQQQQQSEQPFFSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IYI6</accession>
    <name>A0A2H3IYI6_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidase C14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_165983</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C14B family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467843">
        <property type="protein sequence ID" value="PCH35042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3IYI6"/>
    <dbReference type="OMA" id="ATIQRCY"/>
    <dbReference type="OrthoDB" id="3223806at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050452">
        <property type="entry name" value="Metacaspase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104:SF30">
        <property type="entry name" value="METACASPASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104">
        <property type="entry name" value="METACASPASE-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="41"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="300"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="55"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="276"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="308"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="334"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="366"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH35042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="569" mass="64534" checksum="7C9ECEB93052D1A2" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IYK0</accession>
    <name>A0A2H3IYK0_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_155690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467843">
        <property type="protein sequence ID" value="PCH35036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3IYK0"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH35036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="95" mass="10442" checksum="172948046F5BDEF3" modified="2018-01-31" version="1">MFELKKNAQDDGIQVPPQRLELARLGVKPIIKSSVVIRDEALRAISMIPVVDGQHASALCALLRFCLRGAPVRCLRITSIRWSDPPHLTITASAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J0A2</accession>
    <name>A0A2H3J0A2_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_145804</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467843">
        <property type="protein sequence ID" value="PCH35401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J0A2"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH35401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="230" mass="24985" checksum="38399C6ED4340EDC" modified="2018-01-31" version="1">MRKTGGELTAFKIGKDSADSGMLRTTCVRHIAALGKVAQASRWHSHTSGTAPKSEGGVQYERPAGSRTQPSSVQSECMDPHSLDPSVPALWRQAASDVLLDELCIVVRPEETQSTHTPAAQLARYVRVCAPQDRGREGLSRSNLLDHCTCTARSLFATRFVRVSPATLAITVACDSRKPGINQSIIAANSMMRGHNPSYVQASHSVCDLKVRNPDQTIRKGTHRRVQTSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J0E1</accession>
    <name>A0A2H3J0E1_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SNF2 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WOLCODRAFT_156114</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4 5">MD-104</strain>
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        <property type="entry name" value="P-loop_NTPase"/>
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        <property type="entry name" value="SNF2-like_sf"/>
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        <source>
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<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J139</accession>
    <name>A0A2H3J139_WOLCO</name>
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        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WOLCODRAFT_156693</name>
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    <organism evidence="8 9">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD-104</strain>
        </source>
    </reference>
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        <property type="project" value="UniProtKB-SubCell"/>
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    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
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    </dbReference>
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        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
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    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="218"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
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        </location>
    </feature>
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            <end position="212"/>
        </location>
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            <begin position="250"/>
            <end position="287"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
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            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="937" mass="104911" checksum="7249C5B87F927370" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
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            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR 38B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40132:SF1">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR 38B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="454"/>
            <end position="479"/>
        </location>
    </feature>
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            <begin position="85"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="210"/>
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        </location>
    </feature>
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        </source>
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    </evidence>
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        <source>
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        </source>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
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                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
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                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
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                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
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                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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        </location>
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    </evidence>
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            <dbReference type="EMBL" id="PCH36982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
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<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
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                <person name="Barry K."/>
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                <person name="Martinez A.T."/>
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                <person name="Heitman J."/>
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                <person name="Hori C."/>
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                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
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                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
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                <person name="Ling A."/>
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                <person name="Lundell T."/>
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                <person name="McLaughlin D.J."/>
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                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
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                <person name="Slot J.C."/>
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                <person name="Stenlid J."/>
                <person name="Sun H."/>
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                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
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                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
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        <property type="match status" value="1"/>
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        <location>
            <begin position="138"/>
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        </location>
    </feature>
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        <location>
            <begin position="42"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH37210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="158" mass="18109" checksum="F873B783E6039B98" modified="2018-01-31" version="1" fragment="single">MYWRQPSQLSFSRGWIFEITMASITPPEVVEFLVQESTLMGYISGAGAVLILYDYILTFNQERMLMWGSKSRVITAIFLVNRCVMLSTCISLILNLPIWKDVVSEEVTYYLFEVAEILSPTLWAVFSAFRSYIVSNHCWPTTLLTLVLGLMPVFTTLI</sequence>
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<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
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    <protein>
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            <fullName evidence="2">Uncharacterized protein</fullName>
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            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
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                <person name="Kumar T.K.A."/>
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                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
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                <person name="Ruiz-Duenas F.J."/>
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            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17 19">DNA polymerase II participates in chromosomal DNA replication.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 19">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 19">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="18">Heterotetramer. Consists of 4 subunits: POL2, DPB2, DPB3 and DPB4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 19">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 19">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="19"/>
    <dbReference type="EMBL" id="KB467909">
        <property type="protein sequence ID" value="PCH37205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="742152.A0A2H3J6C0"/>
    <dbReference type="OMA" id="MLDQCRY"/>
    <dbReference type="OrthoDB" id="10060449at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008622">
        <property type="term" value="C:epsilon DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008310">
        <property type="term" value="F:single-stranded DNA 3'-5' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006287">
        <property type="term" value="P:base-excision repair, gap-filling"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045004">
        <property type="term" value="P:DNA replication proofreading"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006297">
        <property type="term" value="P:nucleotide-excision repair, DNA gap filling"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05779">
        <property type="entry name" value="DNA_polB_epsilon_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05535">
        <property type="entry name" value="POLBc_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.60:FF:000002">
        <property type="entry name" value="DNA polymerase epsilon catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000010">
        <property type="entry name" value="DNA polymerase epsilon catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1600.10:FF:000006">
        <property type="entry name" value="DNA polymerase epsilon catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.342.10">
        <property type="entry name" value="DNA Polymerase, chain B, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013697">
        <property type="entry name" value="DNA_pol_e_suA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029703">
        <property type="entry name" value="POL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055191">
        <property type="entry name" value="POL2_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054475">
        <property type="entry name" value="Znf-DPOE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10670">
        <property type="entry name" value="DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10670:SF0">
        <property type="entry name" value="DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08490">
        <property type="entry name" value="DUF1744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22634">
        <property type="entry name" value="POL2_thumb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22912">
        <property type="entry name" value="zf-DPOE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23250">
        <property type="entry name" value="zf_DPOE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01159">
        <property type="entry name" value="DUF1744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 19" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 19" id="KW-0235">DNA replication</keyword>
    <keyword evidence="14 19" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11 19" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="12 19" id="KW-0408">Iron</keyword>
    <keyword evidence="13 19" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 19" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="15 19" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="10 19" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 19" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNA polymerase epsilon catalytic subunit A C-terminal" evidence="21">
        <location>
            <begin position="1402"/>
            <end position="1793"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1133"/>
            <end position="1156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00057054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00065544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU365029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="SMART" id="SM01159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="PCH37205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="2110" mass="241086" checksum="D4F7C9F1B8D6A35F" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J6X2</accession>
    <name>A0A2H3J6X2_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_166301</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467854">
        <property type="protein sequence ID" value="PCH35513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J6X2"/>
    <dbReference type="STRING" id="742152.A0A2H3J6X2"/>
    <dbReference type="OrthoDB" id="2637653at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="2">
        <location>
            <begin position="17"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH35513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="237" mass="27114" checksum="DAED778C27BC5555" modified="2018-01-31" version="1">MSEQAARFSFIIPFKSLCAAFTFILYDTVLNIADEVEYIWKGPRSWTKWAYAFIRHMPYLAQGGMTVLFAHMYSTHLWTQKQCVAWWVYQASVFEGLLIAVEGVFILRICALYSYHRVLTSGILVLYFVEIAAMITVLAVATPVMQFNPECLIVKTPPIFATYWIISLAFETFLFGLIIVKFFTSVSRQLGRRSILFVLVRDGMWAYAIIFGLTCFAQPTAGIFRTGLEHDLNMDSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J734</accession>
    <name>A0A2H3J734_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glutathione-S-transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WOLCODRAFT_166345</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467854">
        <property type="protein sequence ID" value="PCH35583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J734"/>
    <dbReference type="STRING" id="742152.A0A2H3J734"/>
    <dbReference type="OMA" id="PEGPWFL"/>
    <dbReference type="OrthoDB" id="4951845at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045174">
        <property type="term" value="F:glutathione dehydrogenase (ascorbate) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00570">
        <property type="entry name" value="GST_N_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005442">
        <property type="entry name" value="GST_omega"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050983">
        <property type="entry name" value="GST_Omega/HSP26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968:SF6">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE OMEGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01625">
        <property type="entry name" value="GSTRNSFRASEO"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="2">
        <location>
            <begin position="25"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="3">
        <location>
            <begin position="112"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PCH35583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="258" mass="29692" checksum="0B86DA2C8437907B" modified="2018-01-31" version="1">MGHENIHPVATGPAAETVAQHQDPQDRVLYAGWFCPFSQRAWITLEEKKISYQYKEVNPYNKERDLHFLDINPKGLVPAIEYKGRALYESLILCEFLEDAYPDHTPHLLPKDPFERAYVRLWIDHVSKAIIPAFYRTVQAQEPEKQQTGLQEFCKALRTISEKAKGPYFLGEQFSFVDVAIAPWAVRDYIVKEHRGYIRAAVGGGWKEWAEQLEKRESVIKTFSLPEHYRTFYATYLRGEAQGEIAKAIRSGRGSSGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J7B6</accession>
    <name>A0A2H3J7B6_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">WOLCODRAFT_128544</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB467931">
        <property type="protein sequence ID" value="PCH37535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J7B6"/>
    <dbReference type="STRING" id="742152.A0A2H3J7B6"/>
    <dbReference type="OMA" id="IMQAKPA"/>
    <dbReference type="OrthoDB" id="419768at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061817">
        <property type="term" value="P:endoplasmic reticulum-plasma membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04041">
        <property type="entry name" value="C2A_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04052">
        <property type="entry name" value="C2B_Tricalbin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21676">
        <property type="entry name" value="SMP_Mug190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057349">
        <property type="entry name" value="C2_Mug190_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037767">
        <property type="entry name" value="C2A_Mug190-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037765">
        <property type="entry name" value="C2B_Tricalbin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47348">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 190 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47348:SF3">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 190 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25331">
        <property type="entry name" value="C2_Mug190_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25669">
        <property type="entry name" value="SMP_MUG190-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-LTD" evidence="14">
        <location>
            <begin position="199"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="424"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="608"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="642"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="969"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="41"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="642"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="657"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="977"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1041"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1056"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1067"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PCH37535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1134" mass="125065" checksum="46EEF584A387A2AA" modified="2018-01-31" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J7B8</accession>
    <name>A0A2H3J7B8_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Translation initiation factor IF-2, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WOLCODRAFT_96573</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.</text>
    </comment>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="InterPro"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="IF2_mtIF2_II"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
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        <property type="entry name" value="TF_IF2_bacterial-like"/>
    </dbReference>
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        <property type="entry name" value="TIF_IF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023115">
        <property type="entry name" value="TIF_IF2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036925">
        <property type="entry name" value="TIF_IF2_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381:SF20">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EF-G_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52156">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 12" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Tr-type G" evidence="11">
        <location>
            <begin position="56"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PCH38140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="589" mass="63094" checksum="1C5CD7E2ACFABC68" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J7L9</accession>
    <name>A0A2H3J7L9_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_139546</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467832">
        <property type="protein sequence ID" value="PCH34729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="742152.A0A2H3J7L9"/>
    <dbReference type="OMA" id="RDEICST"/>
    <dbReference type="OrthoDB" id="3249523at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH34729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="242" mass="25464" checksum="1957CAD849E90959" modified="2018-01-31" version="1">MTSIKDTDGYATTNLFPTDSGDSRSVPYLSASTDWVCSRCETPPGSSVKWYITSFLSLSSFAALAVTCYAFVAPDSALQKRGVCTDGSITSHSTVAVGDKIVEVSTVSCPASVASRSLTKRQSEGLLDVCDAICSDSCNNDSGDLPPEADDCDTIVDAITILNGSIAPTFTVDSGDMQQLTYGTCRYYFENLSNETLEYCWTALSDMGSAAGAACFPPTEPVYSEGVCQATTGLWVVGAAHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J882</accession>
    <name>A0A2H3J882_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <lineage>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
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                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
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                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
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                <person name="Lundell T."/>
                <person name="Martin R."/>
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                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
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                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
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                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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    <keyword evidence="5 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013984391" description="Hydrophobin" evidence="6">
        <location>
            <begin position="18"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PCH38992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="128" mass="12674" checksum="0430EA30E6E611D4" modified="2018-01-31" version="1">MFSRLAIATALATLVVASPWDTPTTTATKTVTETVTAPAPTVTTAGQCNTGDAQCCQSTESASSAAGSQLLGLLGIVLEDADVLLGLDCSPLDVVGVGSGSECNAEPVCCTENGIGDLISIGCVPISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J9V9</accession>
    <name>A0A2H3J9V9_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">WOLCODRAFT_158549</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">ATP-dependent RNA helicase required for 60S ribosomal subunit synthesis. Involved in efficient pre-rRNA processing, predominantly at site A3, which is necessary for the normal formation of 25S and 5.8S rRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB467954">
        <property type="protein sequence ID" value="PCH39020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J9V9"/>
    <dbReference type="STRING" id="742152.A0A2H3J9V9"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00268">
        <property type="entry name" value="DEADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044742">
        <property type="entry name" value="DEAD/DEAH_RhlB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 11 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="122"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="194"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="445"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="61"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="219"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="460"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PCH39020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="500" mass="54756" checksum="E1C347D71EAE5559" modified="2018-01-31" version="1">MRVRPTADESSSGSKRKKRKREQDCVKESSPKKQRKDALAMKPTEISQAEASIPSARKKGTSAAAGTAPTSSSLTQRPIIHAPECVSPVALALSFDQLNVPSKLHPAFEGFKELTPTQASSWPPAIEGRDVVHVARTGSGKTLALCLSALTRLITSPPKDRKRSKGTATVTMLVLAPTHELAVKTHDTLSALGTPHGIANAAPPSGVDEGSRVQTLGREQGREDDADRRRDARADTTIGERWRVVPYLVLDEADRMLDNGMEGDIRSIIGRIWLTLAPLTVNATWSEAIQRVAASFERDAVRVTVRRDVLTANVSVFVNMPLPPVLATSTYNSVVTFRPAELSTTASTTTPSLSIRARKLEGFKWDNSKDLELELPLDEHFYIPNAQSDPLFDAFMVEYNGNAATLWIFQMTVDKNHDGSARGYGLITNVEKIVRGQLHERAKAVSEEAHRVAGQKRRRSAAEGPRKKLKRAQDVKTIYVLVSPDKASEWTMPPGWKGPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JAB6</accession>
    <name>A0A2H3JAB6_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dienelactone hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_135207</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH33594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JAB6"/>
    <dbReference type="STRING" id="742152.A0A2H3JAB6"/>
    <dbReference type="OMA" id="CATCFFP"/>
    <dbReference type="OrthoDB" id="58297at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47562">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47562:SF2">
        <property type="entry name" value="CARBOXYMETHYLENEBUTENOLIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="35"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH33594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="275" mass="30022" checksum="778B0604CB0867FF" modified="2018-01-31" version="1">MLIKKTYVDVTSKLDPKGGNIRIFVISPNIPAYPQAKFPGVVCFSEIYQVTGPVERFAGQIASHGYIVACPSSFHEFEGPEPIPYDVEGTDRGNKYKAEKELAGYDEDATLAIDLLCSLPNCNGRIATTGMCLGGHLAFRAAFDARVLASVCFFATDIHSATLGKGQNDDTLVRVRNGDLTGKGELVMIFGKQDTHVPRVGRDLIRTTLEDANVTTSFLEVQAQHAFIRDESSKDRWDAALTRTLFGFMVEVFERTVGRDLGPRLGSGGAIEHVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2024-03-27" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JAF9</accession>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">MD-104</strain>
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    </reference>
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        <source>
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        </source>
    </evidence>
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        <source>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
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                <person name="Benoit I."/>
                <person name="Boyd A."/>
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                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
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                <person name="Martin R."/>
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                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
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                <person name="St John F."/>
                <person name="Stenlid J."/>
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                <person name="Syed K."/>
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                <person name="Wiebenga A."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
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    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH39260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="146" mass="14349" checksum="59FD82EA0B343D01" modified="2018-01-31" version="1" fragment="single">PCGPSGPLGTPVPGRAWHPVHGPGAPSLQPAGRSAGRGAAAAARELERPKTIEAGHRPCGPSGPLGTPVPGRAWHPVHGPGAPSLQPAGRSAGRGAAAAARELERPKTIEAGHRPCGPSGPLGTPVPGRAWHPVHGPGAPSLQPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
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    <protein>
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            <fullName evidence="3">Uncharacterized protein</fullName>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Barry K."/>
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                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
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                <person name="Yadav J.S."/>
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                <person name="Benoit I."/>
                <person name="Boyd A."/>
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                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
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                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
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                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="chain" id="PRO_5013736219" evidence="2">
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        <source>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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        </source>
    </evidence>
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<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetE route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the vitamin-B12 independent methionine synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.14" evidence="5"/>
    <dbReference type="EMBL" id="KB468031">
        <property type="protein sequence ID" value="PCH39662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JBN0"/>
    <dbReference type="STRING" id="742152.A0A2H3JBN0"/>
    <dbReference type="OrthoDB" id="1053771at2759"/>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00082"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003871">
        <property type="term" value="F:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013215">
        <property type="entry name" value="Cbl-indep_Met_Synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002629">
        <property type="entry name" value="Met_Synth_C/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30519">
        <property type="entry name" value="5-METHYLTETRAHYDROPTEROYLTRIGLUTAMATE--HOMOCYSTEINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08267">
        <property type="entry name" value="Meth_synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01717">
        <property type="entry name" value="Meth_synt_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="UROD/MetE-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Cobalamin-independent methionine synthase MetE N-terminal" evidence="13">
        <location>
            <begin position="2"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Cobalamin-independent methionine synthase MetE C-terminal/archaeal" evidence="12">
        <location>
            <begin position="245"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="Cobalamin-independent methionine synthase MetE C-terminal/archaeal" evidence="12">
        <location>
            <begin position="357"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PCH39662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="459" mass="51594" checksum="C4865F233465AE26" modified="2018-01-31" version="1">MTDFKLNVNKALEEYNEAKALGIATPSLPSPGFQPISLLPKVLPVYKQLPADLKAADAKWIQVDEPVLDSAAYLEKQYASAYAALAPVSPKIALTTYYGRLDSNVTFVAKLPVAGLHIDLDPFSLGIVSGRNIWKADLQAGLALGQKAIAALGAERVVVATSFLLHTPVTLATENKLTAEQKDWFSFALEKATEVSVLASAISGSQDAAHREFERTSDDAARKHVASTTADMLERNSPFAVRKEQTEIRTARVKLNKKEITQEEYEDFIKKEMEHVVRFQERIGLDLLVHGEPERNHMIQYFGEQLEGFVFTQNGWVQIYSSRMLTGPVTTLNWSFPHTDVYRELQYMQLALALRNEVLPLRKADREPYLKWTLPSFKLATTGVTDSFQTHSHFCYSDFNDIFPSYQGADMTLLKTFKQYGYSHQISSSVYDVHSPRKKTEASLVNLVNAARWARQMYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JC59</accession>
    <name>A0A2H3JC59_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AP-3 complex subunit delta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WOLCODRAFT_135594</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Adaptor protein complex 3 (AP-3) is a heterotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH34264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JC59"/>
    <dbReference type="STRING" id="742152.A0A2H3JC59"/>
    <dbReference type="OMA" id="SGNNWMA"/>
    <dbReference type="OrthoDB" id="10264595at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030123">
        <property type="term" value="C:AP-3 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017105">
        <property type="entry name" value="AP3_complex_dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22781:SF12">
        <property type="entry name" value="AP-3 COMPLEX SUBUNIT DELTA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22781">
        <property type="entry name" value="DELTA ADAPTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037092">
        <property type="entry name" value="AP3_complex_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="9">
        <location>
            <begin position="20"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="380"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="681"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="785"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="382"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="740"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="796"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="880"/>
            <end position="893"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR037092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PCH34264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="904" mass="99256" checksum="5B6D824D48D2111B" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JCA4</accession>
    <name>A0A2H3JCA4_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_147675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JCA4"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH33587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="117" mass="13141" checksum="85071E719C685488" modified="2018-01-31" version="1">MRRRGTSEGHPRSGTDSPRRTHDSLTRLPRPLRRRHQLRARRGTDGTRSGQYGQTLLNNIAGQETQTRPSISNLTELCYHRSWPDSLPNELIAARWLTGNDASPIDEASDIGRITAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JCA6</accession>
    <name>A0A2H3JCA6_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">WOLCODRAFT_161931</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468053">
        <property type="protein sequence ID" value="PCH39880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JCA6"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="29"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH39880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="244" mass="26787" checksum="13023F59A0FF917F" modified="2018-01-31" version="1" fragment="single">MENNRWWSAQSSLCEGEQDMQDEIKEMREHLLEEDGNEAEDEEDWLWPSPRSLALSSPTPSTENIRYATQALELVPARWGHDVARAETIMDSLQSASHDSQVASADGSHAVGSHDDLAVSAFSSSPHVFADESYVDHSLDPPSTSTDSTHPRNSHLRLDVSELSPKQATEVGFQRNQVRKTRLQSGRQQKSVMVSQHDRSPTQAVDTSVIDTSVVDTSVVDTSVVDTSVVDTSVINTSVINTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JDA9</accession>
    <name>A0A2H3JDA9_WOLCO</name>
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        <submittedName>
            <fullName evidence="1">HAD-like protein</fullName>
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        <name evidence="1" type="ORF">WOLCODRAFT_106403</name>
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        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycetes</taxon>
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            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467832">
        <property type="protein sequence ID" value="PCH34684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OMA" id="WEPSAMY"/>
    <dbReference type="OrthoDB" id="2012566at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02603">
        <property type="entry name" value="HAD_sEH-N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43611">
        <property type="entry name" value="ALPHA-D-GLUCOSE 1-PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43611:SF3">
        <property type="entry name" value="FLAVIN MONONUCLEOTIDE HYDROLASE 1, CHLOROPLATIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
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        <property type="match status" value="1"/>
    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH34684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="496" mass="55710" checksum="4867F0DDA95FA37C" modified="2018-01-31" version="1">MSGSRYTALILDLADVLFSWSSQTNTAIPPSTLKAILASPIWSDYERGRISEMTCFERVAATFSEDPDEISAAIASARHSLKTNEEMIALLRDMKDNLCGRLRIFALSNISVPDYQFVKSLPFDWTIFDDVFPSGVIGERKPDLAAYQYVITATGINPLTTVFVDDRPENVASARSFGMHGIIFTHQEDVFRALRSLFQDDPLKSGHAFLHANARQLRSVTDGGISFMENFTQLLILELTHDENLVKIQPAMLTWNFFQGNPFYETFPDDIDTTSLAMTIMPNDTSHITAVMDEILKLRNSDGILQAWLDPSRPRVDPVVNINALCLFYKYGRGHELEKPLRWIRDILQQNQHIEGSRYYSSPDCFLYFVGRFLSHSNNPHPHKLLRPALVKRTRERIGTNGDAMELSMRLIVCAGLGICNKVDMEALRLLQCDDGGWEVGWLCCFGSTGVRIGNRGLSTALAIRAIELNSAQCVPGEQSFQMHCITSVAKKILIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JDD1</accession>
    <name>A0A2H3JDD1_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acid protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WOLCODRAFT_116315</name>
    </gene>
    <organism evidence="5 6">
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        <name type="common">Brown rot fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468053">
        <property type="protein sequence ID" value="PCH39891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JDD1"/>
    <dbReference type="STRING" id="742152.A0A2H3JDD1"/>
    <dbReference type="OMA" id="YTYINFG"/>
    <dbReference type="OrthoDB" id="15189at2759"/>
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        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
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        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013615076" evidence="3">
        <location>
            <begin position="23"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="435"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="4">
        <location>
            <begin position="55"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PCH39891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="510" mass="54324" checksum="5BCC0C9D472F32BC" modified="2018-01-31" version="1">MKAAAITLSLSLLALHFESAGAIQLDLVGRPAQHLRKRASITGSSGLTDSSNIAYYVNLTLGGAEFEVQIDTGSSDLYVAGTVPNSKDTGKTSGVAYAVGAVSGPIKTATLDFLGYTVDNQAFLNIEANSNNQTSGTGLIGLGPHTGSQIQETLGNGTGDPALDRIFQQNKTTPNYITVLLGRANDPAEPLPGNLTIGEVLPGYSNITSQPKLNVTVLPNTESEGQHWQTLLDADGIIGPDGKVVDVTTGVASTSNNKQLTVVFDTGYSLPQVPSSVASAFYESVPGAQLVDVPDLDGPIWQIPCEYEINVTFKFGGISFPVNPLDTSLDLNGTDGDGEKTCYGGFQPIDVAKSPLYDIIFGMAFLRNVYMLIDFGDFVDNATDTRDDPYIQLLSISNASASIHNEFVKLRGSASWDPSSDVNAAEGWIRSHRSLFIGLCVVAGLFVLGGLALTIAACRRRRMARSPAGFMNFQSSYRPLGEPAPREAHDLHLMGANQAQSYNNPWDSRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JDR3</accession>
    <name>A0A2H3JDR3_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RTA1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WOLCODRAFT_148911</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="PCH37953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OMA" id="YAINFAH"/>
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    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF9">
        <property type="entry name" value="SPHINGOID LONG-CHAIN BASE TRANSPORTER RSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="130"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="166"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="253"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PCH37953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="299" mass="33575" checksum="ADAA4838D74D148B" modified="2018-01-31" version="1">MEFEYENLAARGNKYFNRTPYGYTPDKWVGILFIVLFSLTALCHAIQAVRYRLWWLLGTACVAGALEIIGWGGRLWSAYNVLLNTPYLMQIVCTIIAPTPLVAANFIILGRVIQKLGSQYSRLSAKWYTAVFVSCDIVALVVQAVGGGAASAAVNQDKNPNNGGHIMLAGIVFQMAAITVYMLLAGEFILRYLYNKPIRGSAAAAPGVLTPRMKQMLFALTFSSLCIYVRSWYRTIELADGWFGRIIETQRYFVIMDAMMIVFAMVALNLFHPGRLLFREDDWDSDVQMQEAFNKKQTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JE38</accession>
    <name>A0A2H3JE38_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleotidylyl transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_28878</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467909">
        <property type="protein sequence ID" value="PCH36999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JE38"/>
    <dbReference type="STRING" id="742152.A0A2H3JE38"/>
    <dbReference type="OrthoDB" id="5591297at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000309">
        <property type="term" value="F:nicotinamide-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31285">
        <property type="entry name" value="NICOTINAMIDE MONONUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31285:SF0">
        <property type="entry name" value="NICOTINAMIDE MONONUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH36999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="250" mass="27043" checksum="8DD35336E1B5C9B6" modified="2018-01-31" version="1" fragment="single">MAALSTLIEHVHADLSPVELVYTSHEHGPHARPSLPSPRHLSSRIRITVLDSFNPPARAHLALANALRLPALLPGDALYAQRLETMMRVAPDVCHGNAGAGANTRADTAYDNVAVGIIHVPTFVGKSSTLLAHLRHRSSAVLDTSAPQLAAGHDACDQSAGDGTYAGTALSMQPQLLAFLVGMDTLERLFAPHFYESEEVMFASLRQFFASDGDNARIVCARRSLRPLHQENEAGRKLMQDAEEYLQLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JET4</accession>
    <name>A0A2H3JET4_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_157954</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
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        </lineage>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
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                <person name="Riley R."/>
                <person name="Barry K."/>
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            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
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                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
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                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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    </evidence>
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            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Barry K."/>
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                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
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                <person name="Kumar T.K.A."/>
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                <person name="Ohm R.A."/>
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    </evidence>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">MD-104</strain>
        </source>
    </reference>
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        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
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        <property type="protein sequence ID" value="PCH37949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OMA" id="THDPTWE"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0031519">
        <property type="term" value="C:PcG protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Zinc finger protein 1053"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="zinc finger protein 19"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
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        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
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        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G10380)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR PROTEIN YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="369"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
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        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="427"/>
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        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="457"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="162"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="327"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="570"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="39"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="203"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="220"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="277"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="570"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
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    </evidence>
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        <source>
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        <source>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH37949.1"/>
        </source>
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        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="647" mass="70215" checksum="03DB3CB98324CBF7" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JH45</accession>
    <name>A0A2H3JH45_WOLCO</name>
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        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_19913</name>
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    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
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        </location>
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        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
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        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JH93</accession>
    <name>A0A2H3JH93_WOLCO</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">WOLCODRAFT_28913</name>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467909">
        <property type="protein sequence ID" value="PCH37088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="742152.A0A2H3JH93"/>
    <dbReference type="OMA" id="GMAPYES"/>
    <dbReference type="OrthoDB" id="2802742at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH37088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="293" mass="31370" checksum="F01044F1DEF0CBE8" modified="2018-01-31" version="1">MNTNTNTSFASGTHSAYDQDALTEIALSICERVAALSNARAPITPDEPLMLAGLNPASVVQLHAWLQAQYDWDDEKRLLFDEEITAEGLARDIVPVTASLPGDADTSVSADAREDASPEGALPAIRIEVHDEMRRHGRDSAPRSVPESASQYLAAEAVLDDIGMAPYESWTGSGKRSKRGGMIFGLIALGLLGSPLPSSSPSLPSSLPCQSPRPPSLFPLIGAPAHVHNPVFSPSVAHTPLFSPWLAAVRFHGMEPMQSPWVPTIPQARSRTKTRRGSHGLGAFPKSPRGFRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JIJ4</accession>
    <name>A0A2H3JIJ4_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_140925</name>
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    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467931">
        <property type="protein sequence ID" value="PCH37558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JIJ4"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH37558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="75" mass="8651" checksum="B521C79707281F02" modified="2018-01-31" version="1">MEHKNRRYLLYSVRFKDIPQDCITFLGSIQPSPLYVRRPTPAHRSAGSLSCNLSHPRSFEELPMDANHSLCGNRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JIW3</accession>
    <name>A0A2H3JIW3_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Tubulin alpha chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">WOLCODRAFT_24771</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 14">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="14">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH41475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JIW3"/>
    <dbReference type="STRING" id="742152.A0A2H3JIW3"/>
    <dbReference type="OMA" id="YMASCIL"/>
    <dbReference type="OrthoDB" id="1662883at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02186">
        <property type="entry name" value="alpha_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000005">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000001">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000008">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002452">
        <property type="entry name" value="Alpha_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01162">
        <property type="entry name" value="ALPHATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10 14" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 14" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="15">
        <location>
            <begin position="48"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="16">
        <location>
            <begin position="247"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
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            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Barry K."/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH37694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="398" mass="45262" checksum="19D3EC27F24F891B" modified="2018-01-31" version="1">MTFVLPPELWDETIDHLWDDPKALTACALTCRDWVPSSRLHLFRTVRIQSAKHCARFAALLADRPEIAPCVRRFTISAEYAGIDSHGEPKEDDEWVDNVADIVPLLVNVSTVGLSRVRWGVLQPKTQDVLKRMFRRVHTLFLFEVRFLASADVITFLSAFPVLNELYFHGVSWTHESPAPLLKFDADGNVVADSQEQQAMRLSYLFLDARSSPTLVTEWLLNHPSEQRLRTIQLCWREIDNMKAVGDLLHASGSALERLLVEFPAGIPEEAVLHNQISLVHNTGLRSLHFGGLNAAQSRNFLAQQLFPWVSAMLSQIRSRTLQEVTFEFEITSVRDLLSLDWARIDRDLSREEFKGLHVLFYVSCEDAVPQTVKEVQALISDRLEGFRERGTLCVSCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JMC0</accession>
    <name>A0A2H3JMC0_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_23742</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468053">
        <property type="protein sequence ID" value="PCH39949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JMC0"/>
    <dbReference type="STRING" id="742152.A0A2H3JMC0"/>
    <dbReference type="OMA" id="SAGCTIQ"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="333"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="55"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="139"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="337"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH39949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="384" mass="42873" checksum="F712A99C6CFBD450" modified="2018-01-31" version="1">MLSRTKSSRSSILSRLRNSSALSRKSVSSDVSIVTVDGGSPVGSVISLPDDAEVIEELESRLVDAEEALASKNDMIKTLEKVRDELESNLTQLRQECDDLQESVAAKDMLVSELRTRCDLSDAQRASIATALAARSAELDTERTARLEAEEQLRELQVRLEESEVERAAMQLAHNTKSSELEAKAVELEAERASRLEAKSRKREMRARYETSEAERAAAEKALAATFSEIEAERAARTQAEMRTQELEVRWAAVKSQSAYTEEALAARTTELEAERASRQQAKARADAQAREIKVLTSCVESLTACLKRGNDEYEAKMRRLATVLETSKQTCGKLRAQRDQARERAQELEEELADVSVAREEGSDWTSRPASEEDADPKYYEDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JMF1</accession>
    <name>A0A2H3JMF1_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_33260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467943">
        <property type="protein sequence ID" value="PCH38908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JMF1"/>
    <dbReference type="STRING" id="742152.A0A2H3JMF1"/>
    <dbReference type="OMA" id="MAVTIHY"/>
    <dbReference type="OrthoDB" id="2798374at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH38908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="72" mass="8180" checksum="6BD0579632F59419" modified="2018-01-31" version="1" fragment="single">LLYVGDDNLDNSDIPHRTKLKQLLTARFSELQESIASDAQNALGRVSFTSDLWTDHQLRGFMAITLHFCTKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JMQ1</accession>
    <name>A0A2H3JMQ1_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA glycosylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WOLCODRAFT_121960</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the alkylbase DNA glycosidase AlkA family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468146">
        <property type="protein sequence ID" value="PCH43456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JMQ1"/>
    <dbReference type="STRING" id="742152.A0A2H3JMQ1"/>
    <dbReference type="OMA" id="GVYYMWS"/>
    <dbReference type="OrthoDB" id="415889at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032993">
        <property type="term" value="C:protein-DNA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032131">
        <property type="term" value="F:alkylated DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008725">
        <property type="term" value="F:DNA-3-methyladenine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043916">
        <property type="term" value="F:DNA-7-methylguanine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.30:FF:000004">
        <property type="entry name" value="DNA-3-methyladenine glycosylase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051912">
        <property type="entry name" value="Alkylbase_DNA_Glycosylase/TA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43003">
        <property type="entry name" value="DNA-3-METHYLADENINE GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43003:SF5">
        <property type="entry name" value="DNA-3-METHYLADENINE GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="5">
        <location>
            <begin position="150"/>
            <end position="307"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="294"/>
            <end position="387"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="365"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PCH43456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="439" mass="46218" checksum="9515BF3E828FD7BA" modified="2018-01-31" version="1">MPPVTRSASRAASTNAAVSAPAPAAEAKEPVPAKTAFGRKRKASNENETASTTPRKKVKVKSGTAPADAPAAESGASTASNSRAQQDALADAESAPVLVPAVLSFSFDDAKAHLVRADARFAELFARMPCRPFEHLARVDPFQTLANSILGQQISWLAARAIAHRFIRLFDPSLPERPPEHSSSITFFPTARQVAQTDVTTLRGAGLSGRKAEYVLDLAARFADGRLSTEKLLRADDDALYEMLTAVRGIGRWTVDMFALFSLRRPDILPVGDLGVQRGVLRWHLALHSPTAHPLSISPAKLPRAPTEEPEGGAEASTSRLEEARGVTPDASSVPPAPATPARGKGKGRSRGTSGGGGVLPAPLTPSTAQTLSMHASGDPPPPLPAGLTAAGLAGRLDGKKKIKGALLTPGEMEALTDAWRPYRSLGVYYMWALAGPPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JMW1</accession>
    <name>A0A2H3JMW1_WOLCO</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_67587</name>
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    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="742152.A0A2H3JMW1"/>
    <dbReference type="OMA" id="QFFPNIV"/>
    <dbReference type="OrthoDB" id="408493at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH40149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="421" mass="47135" checksum="CE1713CC6F44846E" modified="2018-01-31" version="1">MHSTLFASGIMIHSIVLLISQVDQPSGAIWAKFDPLMPQPWAAYFLQAAASLSALAVTYYWDAATKGVLASTSAAVCILLVGLSSGKTPFVLVGGCLLTISASFLYLAHHTDIEDDARHGKRAAIPFRRLVSAVLLVSSLFYLVLGASHEWGRVLDHSEKPATVSEVLDEATASCHRRPLASLEYWPVERTYHAFDNVLLIVFFSHARYDANLDYYKEVYSQFFPNIVFVGPGSREDKGFAHSYDVVVDSYQSDEDLNDPTFYKMAGRMAHHMLFTVMRENDCYDGYLWAPFDTLLNVPRLQQFDQNLFWYHSPFGQYVPNPAFSDMAANMNKSRHAPPANLSPDPTVDLTATWRGWGPDWCDPHVGLAIWAAGMEVDTFHTFHWGDRGADGVWRGNFDHIADVRSLLVESAQMQGVEWPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JN86</accession>
    <name>A0A2H3JN86_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
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    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
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                <person name="St John F."/>
                <person name="Stenlid J."/>
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                <person name="Syed K."/>
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                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OMA" id="LRWHGWK"/>
    <dbReference type="OrthoDB" id="2745598at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH43642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="359" mass="40135" checksum="7AB2EA75C8815324" modified="2018-01-31" version="1">MNAARVTALNLPGHILEDVFKLSGSRKALIDIMLVHSSWYEIAESLQYSDLVLNFTWGDNRPSRCLETLKIRCNAARAARHLTISGLSTSEARDLLLAALAKTTGLVSLDLQLGDHVLPSKATQELYEDSDGFQAARAFIDSFWSAAQAQLTRSSFLPRLEALRTNDVRLIHYLAPERPLDAVGLLEDVKTHDYEIVASSLLKSTSRILQLRLDLVVDNLETAADILRSIAQTFPTTRTLVIVFRLPSARGLEFINQICPILALLSCLEVLSLALMPNPILPSCDYEAKTKELAQLIVNSNPLLTRVDVRWHGWTVFNGALSRKSIAYSDLLRQPTRWSYSDTRPKSPFHYHTVFDPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JNP7</accession>
    <name>A0A2H3JNP7_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6535 domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="4" type="ORF">WOLCODRAFT_153574</name>
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    <organism evidence="4 5">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Phaeolaceae</taxon>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468146">
        <property type="protein sequence ID" value="PCH43521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JNP7"/>
    <dbReference type="STRING" id="742152.A0A2H3JNP7"/>
    <dbReference type="OMA" id="WIACSAL"/>
    <dbReference type="OrthoDB" id="2796682at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045338">
        <property type="entry name" value="DUF6535"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20153">
        <property type="entry name" value="DUF6535"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="221"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="256"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6535" evidence="3">
        <location>
            <begin position="104"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6535" evidence="3">
        <location>
            <begin position="162"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20153"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH43521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="653" mass="72897" checksum="3053B9988197DA84" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JP28</accession>
    <name>A0A2H3JP28_WOLCO</name>
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        <submittedName>
            <fullName evidence="3">Alpha/beta-hydrolase</fullName>
        </submittedName>
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        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
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        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Phaeolaceae</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468146">
        <property type="protein sequence ID" value="PCH43942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="742152.A0A2H3JP28"/>
    <dbReference type="OMA" id="SLWVQYR"/>
    <dbReference type="OrthoDB" id="2152029at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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            <begin position="142"/>
            <end position="361"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH43942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JPH8</accession>
    <name>A0A2H3JPH8_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">WOLCODRAFT_149468</name>
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    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Agaricomycetes</taxon>
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            <taxon>Phaeolaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="PCH38534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OMA" id="DRSDEPW"/>
    <dbReference type="OrthoDB" id="2797650at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013588115" evidence="2">
        <location>
            <begin position="21"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="132"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH38534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="174" mass="18285" checksum="C3EC47F64CB99D37" modified="2018-01-31" version="1">MPAFRVCLILLVTLVVSVQSHPMDLGRGLSELDSITNPDELFAPISGAGSSPLNELESGNLLGRHYTLQVHTPPANGTPRARSASRRRLVPFPKYLSERAALGAGQTQDNDEDVNHVSHVGPAPANNPPAAPQQASSQSGDDSSVTLVPRPTSSKHSQATTKQNSQAASAKHAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JPN9</accession>
    <name>A0A2H3JPN9_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Meiotic nuclear division protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WOLCODRAFT_132770</name>
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    <organism evidence="8 9">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
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                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the MND1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468146">
        <property type="protein sequence ID" value="PCH43455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="742152.A0A2H3JPN9"/>
    <dbReference type="OMA" id="VCYWAFP"/>
    <dbReference type="OrthoDB" id="273345at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040661">
        <property type="entry name" value="LZ3wCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005647">
        <property type="entry name" value="Mnd1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040453">
        <property type="entry name" value="Mnd1_HTH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18517">
        <property type="entry name" value="LZ3wCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03962">
        <property type="entry name" value="Mnd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026991">
        <property type="entry name" value="Mnd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mnd1 HTH" evidence="6">
        <location>
            <begin position="26"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="Leucine zipper with capping helix" evidence="7">
        <location>
            <begin position="153"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
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        </source>
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        </source>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <sequence length="208" mass="23200" checksum="C2A59E9A9A08C92F" modified="2018-01-31" version="1">MASCPVQSQIAPRGLSAEEKRVKLIEIFHETLKELEKLGPKMKGIVSQSVKEVLQGLVDDGLVQADKIGSSNFFWSFPSQRGAMMQNRLVAVKESQASHRAQLVELRASIESEKAARPDSEERAQALNKLAAAKKEVTDLENELAQCGACDPVKVEEKKRAVMLAKEAAVRWTDNYLLLLSYFTRQTCVDPAEIKKYLGVDDEYEDIC</sequence>
</entry>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
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                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
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                <person name="Lindquist E."/>
                <person name="Ling A."/>
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                <person name="Nagy L.G."/>
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                <person name="Ohm R.A."/>
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    </evidence>
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    </evidence>
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    </evidence>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH40038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="387" mass="40928" checksum="A67257EF2BA23439" modified="2018-01-31" version="1">MSTVAHYLHHSFYVHRDRGAPPPQRLCPAQAALLSGVPPMTSLASLALVCSVGGCPTFIQGQASSRRRFYRAATLAAPYTAFAVFTAVCAKLGAAHPDEVIRPPHALSCTIDLLPFNAIVAAFATAVSLASVVLFAIKVVLLWREGGDGSSIENEKHSMSDVDSEGDPNWQLLVRAGMLALCMLGISIVGLVDIVSSARRDVLDVLRAVAAMAVFIIFGTHPVRVSSTLAVPSSIFSFAHMCDYKGIFGICLRRGTSEPAMHSSSQTLARATPPPSPSPSPTLAFDPTQGLPFDPALPPVPLLPYDQALLFGPTLTDTDRKRVDSATSAKSARLHAARGAGVQIIERPQDAFGRKGTGWGKGASPAASLFEYSVRSREGIGGDETKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JR09</accession>
    <name>A0A2H3JR09_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome b5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WOLCODRAFT_139082</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the cytochrome b5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468157">
        <property type="protein sequence ID" value="PCH44582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JR09"/>
    <dbReference type="STRING" id="742152.A0A2H3JR09"/>
    <dbReference type="OMA" id="FHAPPRI"/>
    <dbReference type="OrthoDB" id="260519at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000009">
        <property type="entry name" value="Cytochrome b2, mitochondrial, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050668">
        <property type="entry name" value="Cytochrome_b5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359">
        <property type="entry name" value="CYTOCHROME B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0349">Heme</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="7">
        <location>
            <begin position="3"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="86"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PCH44582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="110" mass="12339" checksum="E01071513A2166FD" modified="2018-01-31" version="1">MSDRTWTPQEVAKHNKPDDCWVIVSGKVYDVTEFLPNHPGGVRLLLNFAGRDATSAFKPFHTPTALTDALPSEKYLGSIDHARVKALKKKRSTPRRKTVTQDAPRVEVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JS11</accession>
    <name>A0A2H3JS11_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_163218</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH41579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JS11"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH41579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="182" mass="19376" checksum="121594428B3F08AE" modified="2018-01-31" version="1">MANGIYEVSANADKELYRRNAFMRTLGLLGSWFCELVQCNRLSDSGTLSTQECASSPSTEAGDRAIDTDGPDMNPTWAPPRLPARQEKRAATHQIGADVDTTPSFAAASELPPSEPRLAATRSARTSAPSIAREITAALRLASPPREPQGAIYVRAYVPAASIIRHLDPRTGESASAKVAGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JS89</accession>
    <name>A0A2H3JS89_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_91104</name>
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    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468168">
        <property type="protein sequence ID" value="PCH45012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JS89"/>
    <dbReference type="STRING" id="742152.A0A2H3JS89"/>
    <dbReference type="OMA" id="RISEHKD"/>
    <dbReference type="OrthoDB" id="2506088at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31912">
        <property type="entry name" value="IP13529P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31912:SF34">
        <property type="entry name" value="NOTOCHORD-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH45012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="502" mass="56838" checksum="9FEC06783E9F020A" modified="2018-01-31" version="1">MSPVWRIRGIDAHQDTPVKILHVVLLGFVKYLWRDVVQNQLKGKEREKELLATRLSSLDVSGLGISPLAGRTLVQYAGSLTGRDFRAIAQTAPFVIYDLVSHDCFETWVALSKLIPLIWQPEIPNLDDHLAVLEQEMRYFILCAARWSIRWFNKPKFHIFLHLVDHIRRFGPAIFVHSNRHAPSRDIALAFAQGNRIRHLMSSGHFIFRSQTTLSAYSHTDFDHLTGLQPSFSFRKEDWRCIGPGPQRLLAGGDTATQYLGIERQMNIKHGLCISDKKPPREFSQLRTGQMLPNCISGTSNRLFKTCDSVTLKNGDICTPNQIVVVRNQHMAGQTCVARVEEIVQIKGSVSDMACMPDAILLELVSVSNGSSIYHMPLIELTNSWLLVHYEDILCTVNAQHNCAANACDTSGFRYVYQERQRTNQTQAAVVHQRPTDLILNTAQMRDAVHVQQFRIPPQVLDEDEVITASAAQEVHARKAPELKMKRREATIVSNPREVLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JTQ4</accession>
    <name>A0A2H3JTQ4_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Actin-like protein Arp3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WOLCODRAFT_132296</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin family. ARP3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB468124">
        <property type="protein sequence ID" value="PCH42279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JTQ4"/>
    <dbReference type="STRING" id="742152.A0A2H3JTQ4"/>
    <dbReference type="OMA" id="GIHYPIR"/>
    <dbReference type="OrthoDB" id="421448at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10221">
        <property type="entry name" value="ASKHA_NBD_Arp3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000029">
        <property type="entry name" value="Actin-related protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000006">
        <property type="entry name" value="Actin-related protein 3 (ARP3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PCH42279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="431" mass="48333" checksum="D2236820EACD6329" modified="2018-01-31" version="1" fragment="single">MSLLAPIICDNGTGFSKVGYAGNSDPSFVFPTAICTRGPVQQASRSGPAVPPRPGNLASKRGVEDLDFFIGDEALANAQTPGYGVYYPIRHGQIENWDHMERYWEQTIFKYLRAEPEDHYFLLTEPPLNAPENREQTAEIFFESFNIKGLYIAVQAVLALAASWSSNRVTDRTLTGTVIDSGDGVTHVIPCAEGYVIGSAIKHIPIAGRDITQFVLNLLRERGEMASVPPEDHLKVASRVKENYSYVCQDIVKEFRKFDQEPYKYFERFEGEHTVTGRKYSVDVGYERFLAPEIFFNPEIYSSDFLTPLPEIVDGVIQQSPIDVRRGLYKNIVLSGGSTMFQHFGQRLKRDLKQIVDRRLDASFTAGGSQVKSSGVDVEVISHKRQRYAVWFGGSLLASLPEFYSSCHTKAQYDEVGPSICRRYQIFGSAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JTS3</accession>
    <name>A0A2H3JTS3_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_18303</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468146">
        <property type="protein sequence ID" value="PCH43363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JTS3"/>
    <dbReference type="OrthoDB" id="191651at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="89"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH43363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="147" mass="15389" checksum="23F20C6FC4D793F1" modified="2018-01-31" version="1">MSLEYTDANAEHVLAEAERRCAQDVSGAWEVVTSPTPPPPTTPEEEEQGDDVKPEVGQKLPPEAVPDDDGKDVRQSRLKRRTIGAGAKAEGTSGASSSVSVLAGEAGAIVVVSAGPSQRPKWSARTAGGEWGRRCANGRGSQRGRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JU83</accession>
    <name>A0A2H3JU83_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Mitochondrial carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WOLCODRAFT_153576</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468146">
        <property type="protein sequence ID" value="PCH43523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JU83"/>
    <dbReference type="STRING" id="742152.A0A2H3JU83"/>
    <dbReference type="OMA" id="MMVTKKR"/>
    <dbReference type="OrthoDB" id="756301at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
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                <person name="Benoit I."/>
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                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
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                <person name="Hesse C."/>
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                <person name="Kallen N."/>
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                <person name="Ohm R.A."/>
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            <dbReference type="DOI" id="10.1126/science.1221748"/>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PCH42148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="794" mass="86972" checksum="1972D3AFED5E1BDB" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JXX1</accession>
    <name>A0A2H3JXX1_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">COP9 signalosome complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WOLCODRAFT_139278</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalytic Component of the COP9 signalosome (CSN) complex that acts as an regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunit of SCF-type E3 ubiquitin-protein ligase complexes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the COP9 signalosome (CSN) complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M67A family. CSN5 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB468168">
        <property type="protein sequence ID" value="PCH44833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JXX1"/>
    <dbReference type="STRING" id="742152.A0A2H3JXX1"/>
    <dbReference type="OMA" id="VKMKLFQ"/>
    <dbReference type="OrthoDB" id="605656at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000338">
        <property type="term" value="P:protein deneddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08069">
        <property type="entry name" value="MPN_RPN11_CSN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000003">
        <property type="entry name" value="COP9 signalosome complex subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040961">
        <property type="entry name" value="CSN5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050242">
        <property type="entry name" value="JAMM_MPN+_peptidase_M67A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10410">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18323">
        <property type="entry name" value="CSN5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102712">
        <property type="entry name" value="JAB1/MPN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0736">Signalosome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="12">
        <location>
            <begin position="53"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="274"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00058010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PCH44833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="358" mass="39934" checksum="D7867E33CA8227A3" modified="2018-01-31" version="1">MSSSQTAFKTFSLTNDVVEISPQDEIYRFDAETNRRINREQPWTRDPHYFKVCKISAVALIKMVIHARSGVPHEIMGLMQGKVMDNALVIIDSFALPVQGTETRVNAANEANEYMVQYIQGSERVGRVEHAVGWYHSHPGYGCWLSGIDVNTQMTNQKFQDPFVAVVIDPNRTISAGKVDIGAFRTYPETYTPQDAGSSEYQSIPLNKIEDFGVHANQYYPLEVQVFKSSLDAELLGLLWNKYWVNTLSQSALISNRAYAASQLADLAQKLTKAQSSVPSTKAPPPALKDDKAAKKEEKKREDQNQLLKGVKDSDKIAMEAQHGLIAQVLKDVIFSMRPQNVARTELGDAMDTTMSVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JYX1</accession>
    <name>A0A2H3JYX1_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HNH nuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_154146</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468157">
        <property type="protein sequence ID" value="PCH44109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JYX1"/>
    <dbReference type="STRING" id="742152.A0A2H3JYX1"/>
    <dbReference type="OMA" id="WITALEI"/>
    <dbReference type="OrthoDB" id="3269637at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13391">
        <property type="entry name" value="HNH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNH nuclease" evidence="2">
        <location>
            <begin position="130"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH44109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="372" mass="42100" checksum="07E6599A4B658914" modified="2018-01-31" version="1">MTQPLTQNLQLVLLKFQLHQPGNDWITALEIPYDAFPHYSSKPRAWLDYLGYALTGSDGVLSLSSETTDCRNACDLDLPVSPGEVYFFHTSGSVAFIDPHVVTTPSTHSSCSSFLDDDFRRTLIQRDGRCVFTLSKEDSCEASHLLYIRRLTQIRSGGQLDINSIDDPRNGLLIDVGTHARRKYGKVAFIPTPIRSLTSSDVAGAADTAPDSYRLTLHSFTKNARCWRLSVHGYEAQLRLPLPDNWPPEIIFTALYAGWAIKAWGPPGFAELLGKTTDNLYYPDGLYKRDADIGEEELRQRRKEAQDKRRTARREARRQRGELHETKFDAMDAILALWTLNNQPAWERAKEAAKVEAKQRSTEKVTEWLNGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K074</accession>
    <name>A0A2H3K074_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein-lysine N-methyltransferase EFM4</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Elongation factor methyltransferase 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">EFM4</name>
        <name evidence="6" type="ORF">WOLCODRAFT_152432</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that mono- and dimethylates elongation factor 1-alpha at 'Lys-316'. May play a role in intracellular transport.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM4 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="KB468124">
        <property type="protein sequence ID" value="PCH42404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K074"/>
    <dbReference type="STRING" id="742152.A0A2H3K074"/>
    <dbReference type="OMA" id="PTPSFQF"/>
    <dbReference type="OrthoDB" id="10069295at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03188">
        <property type="entry name" value="Methyltr_EFM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026635">
        <property type="entry name" value="Efm4/METTL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12843:SF5">
        <property type="entry name" value="EEF1A LYSINE METHYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12843">
        <property type="entry name" value="PROTEIN-LYSINE N-METHYLTRANSFERASE METTL10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 4 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PCH42404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="259" mass="28279" checksum="7042D20A26D14FD3" modified="2018-01-31" version="1">MSDFTDLPPSRLGTKEHWDAVYSTEYTNFEEIGDEGEIWFGEDSVEKMVDWALENIPPSADSMPYILEVGAGNGNLLLALHEAGYAPDRMCGVDYSADAVRLAKAIADSRGATGEDEEDREEQAKGEKGVGPEAITFAECDFLAEDVSPLSTMPSIEGEKVALWNLVLDKGTFDAMALAGKDENGRSLADNYPTRVGRVVKPGGYFLITSCNFTEEELKAKFTTEQTGLIYHSRIAWPTFSFGGKSGNVYSSVAFQKPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K122</accession>
    <name>A0A2H3K122_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FK506-binding protein</fullName>
            <ecNumber evidence="5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WOLCODRAFT_104216</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5 6">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FKBP-type PPIase family. FKBP3/4 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="5"/>
    <dbReference type="EMBL" id="KB468146">
        <property type="protein sequence ID" value="PCH43808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K122"/>
    <dbReference type="STRING" id="742152.A0A2H3K122"/>
    <dbReference type="OMA" id="TLVKIHY"/>
    <dbReference type="OrthoDB" id="77911at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000006">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.340">
        <property type="entry name" value="Nucleoplasmin core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041232">
        <property type="entry name" value="NPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023566">
        <property type="entry name" value="PPIase_Fpr3/Fpr4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43811:SF19">
        <property type="entry name" value="39 KDA FK506-BINDING NUCLEAR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43811">
        <property type="entry name" value="FKBP-TYPE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17800">
        <property type="entry name" value="NPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001473">
        <property type="entry name" value="FK506-bp_FPR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="8">
        <location>
            <begin position="295"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="51"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="121"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="57"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="134"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="167"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="232"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR001473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PCH43808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="381" mass="42012" checksum="3C0B302B8C05CD99" modified="2018-01-31" version="1">MAVAVALWSQVAKPGDATEVQPLSDLRVTNIALGDDIADPEGRTTVKLVYKVPTVESGDEDEDEDEDDEEQEKGSIELRSTVLCSLTPGKIEQATIDVVLEGEEEYLIEVVGKNTVHLTGNYIDQTPDQVPYNDESEYDSEEEDFDLREVSSDVEIDPEEMDIPSDDEGRFEEIHDEPEQPKADSSKKRPRDSDAMSTDAGEVKLSKADKKKLKKQKVEGGKAVTTSEEAALVEKKEEKKEGKKEQGKKEEKKGAKKDEKEEKKEEKKGDAEKTLAGGVKIKDHKIGTGPKAKAGDSVSMRYVGKLTNGKIFDQNTKGDPFRFRLGKGEVIKGWDVGIVGMQVGGERLITIPPKMGYGSQKIDKIPANSTLVFEVKLVKIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K2A4</accession>
    <name>A0A2H3K2A4_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_164295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468135">
        <property type="protein sequence ID" value="PCH43174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K2A4"/>
    <dbReference type="OMA" id="VCHEKID"/>
    <dbReference type="OrthoDB" id="3253026at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="389"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="463"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH43174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="497" mass="55440" checksum="D21C0E47DBCBC36A" modified="2018-01-31" version="1">MSNFIAHAATVPTVAGRPWYINLRWTAIVLFLPFAGLWQSMILLSQHIMFSRDNLHQALSRGALLMVCRDNDWEPPSDREDRVFVQLPKGFHETSDKHAMQSWAKFKIMHVCHEKIDVSAYNVHGDMLVPRGYSFAKVHKFPLTDILVSTLANTGSMKLARHRSWAKMAVSGAQLMFAFYTLYRARGDQISHYGYAAYGLSVFPYAFMTLINLIAVGVVGDYPCLYVVRSSILREAGLRVGSRFDGAIGVLKDEDKTNAGESEGALGAPASQDFDTKTMLDPDLDTASVESKTFTVSLPELESGSHDEPPLTEAWLRLETLSCGGQPAKRLLVVRAGEWERRFLFASPGQDLTGRDVYEFGIGGITNEDVHYSLGRSEESIIRNYCGGILFYLSFVMAYLMPYMVIYALTGFRREHSTVAQRAWTMGWLCSSQLAFYPLNASILTHTGGLGITLGSFRSNPRFWFTMAILMVAPIGGYVTVSQMYLSSDFTSTTLCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K2G9</accession>
    <name>A0A2H3K2G9_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PKS/mFAS DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_74073</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KB468135">
        <property type="protein sequence ID" value="PCH43244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K2G9"/>
    <dbReference type="OMA" id="WDCRFES"/>
    <dbReference type="OrthoDB" id="3288579at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS/mFAS DH" evidence="2">
        <location>
            <begin position="33"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="1">
        <location>
            <begin position="33"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="1">
        <location>
            <begin position="178"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH43244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="203" mass="23064" checksum="22D4C779BD69B7AD" modified="2018-01-31" version="1" fragment="single">INFSLLNGCPAQYFEGPAYPFQWKLYPLANREPTYLRRLLPPTRPLNSTRLRVSPHIPESWVSHHVIDHSILIPAAAYVEMALEFPDVTHVWDCRFESACILEEGVPPVTLEVAKEGVSWWVKSSTALQTMQGDLEWTRTSPAFDMMHAYGKLGYGKPELYPDSITKVDVDAVLKRCISAHDKDELYADLEGIAQFGPEWVTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K3S0</accession>
    <name>A0A2H3K3S0_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptidase C15 pyroglutamyl peptidase I-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WOLCODRAFT_26118</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C15 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468146">
        <property type="protein sequence ID" value="PCH43684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K3S0"/>
    <dbReference type="STRING" id="742152.A0A2H3K3S0"/>
    <dbReference type="OMA" id="PVNPSWQ"/>
    <dbReference type="OrthoDB" id="407146at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.20">
        <property type="entry name" value="Peptidase C15, pyroglutamyl peptidase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016125">
        <property type="entry name" value="Peptidase_C15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036440">
        <property type="entry name" value="Peptidase_C15-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23402">
        <property type="entry name" value="PROTEASE FAMILY C15 PYROGLUTAMYL-PEPTIDASE I-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23402:SF1">
        <property type="entry name" value="PYROGLUTAMYL-PEPTIDASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53182">
        <property type="entry name" value="Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PCH43684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="238" mass="25428" checksum="C61BE20BA2A3E4C8" modified="2018-01-31" version="1">MPALPPDALRVLITGYGPFRGYPVNPSWQAVRPLHNATVHTPSSTAPRAIHITALEVSTSYAAVLRIVPALHARPPVLPPAADAPPPPADGYDLVVHVGVAGGAPGLRLEQRGRKYAYEIEDADGELCPVADGTIPPQRGFGGGYEEFPNELYTSVDCEKLAGYLKGEGVEKVYTSIDAGLYLCEFINYCSLAEAQRTAVTHEKSTLVLFVHVPDTNVISTPDATDALGKIIAWICSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K3T3</accession>
    <name>A0A2H3K3T3_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Aminopeptidase P</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WOLCODRAFT_139271</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD-104</strain>
        </source>
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        <cofactor evidence="1">
            <name>Mn(2+)</name>
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        </cofactor>
    </comment>
    <comment type="similarity">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
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    </dbReference>
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        <property type="entry name" value="X-Pro_aminopeptidase_P"/>
    </dbReference>
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        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 1"/>
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    </dbReference>
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        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Creatinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16189">
        <property type="entry name" value="Creatinase_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16188">
        <property type="entry name" value="Peptidase_M24_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="13"/>
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        </location>
    </feature>
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            <end position="619"/>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PCH44818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="619" mass="69072" checksum="095A2582324D7F72" modified="2018-01-31" version="1"> </sequence>
</entry>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
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                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
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        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH43177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="110" mass="12935" checksum="FF737750884E7E7A" modified="2018-01-31" version="1" fragment="single">IMGVLIHWMLMGMLILQVYLYYLLFPKDHYIMKIYVYSLFIFETVESCLIMADSFDIFVYGYGNISSLTSYHNTWFSVPIMSALSSAAVQTFFAWRIWKFSNSRLLVVVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K6R0</accession>
    <name>A0A2H3K6R0_WOLCO</name>
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        <submittedName>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
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                <person name="Morin E."/>
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                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
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                <person name="Sabat G."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <end position="136"/>
        </location>
    </feature>
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        <location>
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            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH44754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
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</entry>
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        <submittedName>
            <fullName evidence="13">Cytochrome P450</fullName>
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    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Floudas D."/>
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                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD-104</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468168">
        <property type="protein sequence ID" value="PCH44804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K6V7"/>
    <dbReference type="STRING" id="742152.A0A2H3K6V7"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PCH44804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="495" mass="55503" checksum="2E461F71DDF4FD8E" modified="2018-01-31" version="1">MRTFPPGPKGLPLVGNLFDMPKSQAWKTFTKWSEKWGDVISVSVFGQTIVILNSVECVNELLEKRGSVSSDRPCMVVAKKWAGWDRVMVLEDHTSRFRALRRLTSKYMGTRAAIASLSHVLELEASEFVSRVWRNPERLSDEARRNAGATILMLIYGYRIREEEDPMLKMADKAMESWTIISLPGAFLVDLFPSLEYIPVWFPCIQWRETATTARKLLDCLRNEPFEYTRSQMSEGHSLSSFTAQNLIAAKTKEEEELVKDAATALYAGGSDTTVSAVCSLFLAMMCNTEAQAKAHDELDRVIGSGRLPSLRDRDQLPYVNAICLEVLRWNPVAPAGVAHRLSDNVILDDYLLPKDAIIITNIWKLMHDATKYSDPLQFKPERFLQVGGTQPEPDPRNIAFGSGRRVSELLLGMHLADATLFIVCAMSLAVFNITKPIENGAVIEPEIEYTNGTISHPHPFRCSIKPRSERAESLLLSLTVIGERDAEVQGLKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K7S5</accession>
    <name>A0A2H3K7S5_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Brr2 N-terminal helicase PWI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_154532</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468157">
        <property type="protein sequence ID" value="PCH44487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K7S5"/>
    <dbReference type="STRING" id="742152.A0A2H3K7S5"/>
    <dbReference type="OrthoDB" id="3067468at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041094">
        <property type="entry name" value="Brr2_helicase_PWI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18149">
        <property type="entry name" value="Helicase_PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brr2 N-terminal helicase PWI" evidence="2">
        <location>
            <begin position="191"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH44487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="399" mass="44589" checksum="EDF986BBE8586BA2" modified="2018-01-31" version="1">MSAKQDLSSYSYAAISSLVLTADRSALLRRDKEPNGTPTSLAGRIDPHEMGSRDLEEKKKKATDKQDTSGRQPKCRVEATGFGSLDIINATQDVEGLTHRPCTAGTHEAHDVIHSAANTILEMLKNENMKDFNKKEIEEKITDYGAEDEMQVDAHLERKDAEIDEEMDVVVVFDEEEEGFEIRDELDEENEEAEKTGEAPSSHSKEMRNSLLGLMELFEYQSFHIITKFLKTQDVIVWCTKLIRSDADERTNVKVAMREKGLGWILENLPGTGKRSSLCTDGSWKDECSHRSFSGHPKDAEDSLRIPIAVGVVQISTLTAAHDTTDDMGQMHSVIFRQAIDAALQTRPNLCIITLHWCPGHSNITGNTRTDNLARSVVTLPTSIPLTLPWLRERARIGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3ISQ8</accession>
    <name>A0A2H3ISQ8_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fasciclin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_63532</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH33022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3ISQ8"/>
    <dbReference type="STRING" id="742152.A0A2H3ISQ8"/>
    <dbReference type="OMA" id="FHINSTG"/>
    <dbReference type="OrthoDB" id="286301at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
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        <property type="project" value="TreeGrafter"/>
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            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
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                <person name="Benoit I."/>
                <person name="Boyd A."/>
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                <person name="Ferreira P."/>
                <person name="Findley K."/>
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                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
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                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
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            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Glotzer D."/>
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                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
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            <strain evidence="3 4">MD-104</strain>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Riley R."/>
                <person name="Barry K."/>
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                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
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                <person name="Lundell T."/>
                <person name="Martin R."/>
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                <person name="Morgenstern I."/>
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                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="355" mass="40464" checksum="641949686180BB04" modified="2018-01-31" version="1">MKAAAGPPAEKKGHICPPSNATHPRDRWESAFVYSFMCKFTQLRAKVEGLDSPVDFEDALLLQEPNPIITQILARFVLNLRPQTRNLSSDMITLTLAGVMQEYLKSSERTVFWDEEKKANVDPFAEMNDGFFAASWDLKLKILRQLVELQLCHCAEVKATIDRAWGVIHNKHKKTETTSAPPPASDPQSQENLQLVPLGQDKERKRYWAVDASPRLYVSTNPWKITATFHTVSSTREEYLAVVEHLKQTAPREAKPGERRPKLEQAHLLLLKVLEGRIEIIDAELARIQRARKKIEQRNLLIAQAEVRETRTRRRTTRPDYAYMNDPTSEASHYQSHVQSLPILSALVTGRSGRV</sequence>
</entry>
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        <name evidence="7" type="ORF">WOLCODRAFT_130127</name>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
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                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
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                <person name="Wiebenga A."/>
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                <person name="Eastwood D.C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
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    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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    </evidence>
    <sequence length="400" mass="44395" checksum="C5B02FA0D2DB1794" modified="2018-01-31" version="1">MGIAAELTPAPLVIVEGFLGGGGEVVWGNFQEHSNYACRLDGKEDRKIIFASVGPVSSLHDRACELFYALRGGTVDYGEEHSKLHGHDRYGRTHTSGLYPEWSERMPLHFLGHSLGGPTILKLQHLIRTDFFGSGLDPGMILSLNAVSAPFRGTQSVYILGEDTENAPSVRPWSVGSVLAGLAHTLSYLSPVLPDALDMHAEARHLSFRKCSPLGLLRHLWHSEWATGEDAAPYDVTFGAADARERDKDGMVHPATFYQSYVACMTERSDDASNTHLPSLQYLAILPPLYLISRAMGAIDQEAYWANDGVVPVFSQCHPYDCGVVECKHMTLPLEDADGEDDKLETSEQPVEGVWYVKHVEAATHISIVPFWLGTASQRIFWRDLGDWLWSIDRKRHKVN</sequence>
</entry>
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    <accession>A0A2H3IVM4</accession>
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            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Benoit I."/>
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                <person name="Kuo A."/>
                <person name="LaButti K."/>
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                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
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                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
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                <person name="Martin F."/>
                <person name="Cullen D."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OMA" id="RWRFEYF"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="63"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH34040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="376" mass="41207" checksum="E499AB4BD5F69DDE" modified="2018-01-31" version="1">MSIESDCSPSTSPCTSPQFSRFSRSYSSVSMTLFGSGSALSTSPSIATNSSNPSPTTSPRRFLPLKKIQKSKKSRSCSPLQMVDTSTGFQGSSQAPEIDTPNSEPVTPIMPTFNIPALSNHRRTDSTATTNSAKSVRSVRSCHISSPLASPTSDGLQSVNIPGILSWLNGTTIEFWIDQEGIHAVRSTFRLMGYTSEAVEDRDVDLINALTYGLADFMPTYRQVYKFNSSKVDAPPILRRLTKSGDGDKDYISQQASLTVSSNGVYSVSGVEFFDFQPHRAPLVLRWRFEYFVHDSLTEIPGATVQDTKTLTPLRFSCSPGLLHPTHGKKRTTLLQVFKRSPLLRAQAFSGMPHHIIPVAKMNTRAPSGHFFARGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IVY9</accession>
    <name>A0A2H3IVY9_WOLCO</name>
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        </recommendedName>
    </protein>
    <gene>
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    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the cytoplasmic LSM1-LSM7 complex which is involved in mRNA degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the heptameric LSM1-LSM7 complex that forms a seven-membered ring structure with a donut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
            <location evidence="6">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH33585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3IVY9"/>
    <dbReference type="STRING" id="742152.A0A2H3IVY9"/>
    <dbReference type="OMA" id="DQFANLM"/>
    <dbReference type="OrthoDB" id="10263346at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01728">
        <property type="entry name" value="LSm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034104">
        <property type="entry name" value="Lsm1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044642">
        <property type="entry name" value="PTHR15588"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15588">
        <property type="entry name" value="LSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15588:SF8">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Sm" evidence="7">
        <location>
            <begin position="8"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PCH33585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="136" mass="15757" checksum="1436E29B07C8E19F" modified="2018-01-31" version="1" fragment="single">MDSLIPFTTSGSLVDCVDRKMVVVLRDGRKLQGVLRSYDQFANLVLEDTVERIYYQQLYAEMWRGLFLIRGENVVLLGEIDLDREDEHDLRRVPWPELEPYHNAEIASKKKRDEAKAQILFETKGFCKEGGEGDGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IWE9</accession>
    <name>A0A2H3IWE9_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Plant basic secretory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_94761</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH34061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3IWE9"/>
    <dbReference type="STRING" id="742152.A0A2H3IWE9"/>
    <dbReference type="OMA" id="DAGYQHT"/>
    <dbReference type="OrthoDB" id="891726at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007541">
        <property type="entry name" value="Uncharacterised_BSP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33321">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33321:SF12">
        <property type="entry name" value="PLANT BASIC SECRETORY PROTEIN (BSP) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04450">
        <property type="entry name" value="BSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH34061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="218" mass="24537" checksum="8B33F8F0BC7E98BD" modified="2018-01-31" version="1">MYLPVARTTWIMPNFELTIDDVSHPGAMLFLDNIRPANALRDAVVAVCSGLYTIRDVPGNVQNVRLVLQAMPGVAYTTGSHTHKEIHFSLNHIERSAARARSEITGVLTHEMVHCYQYNARGTCPGGLIEGIADWIRLRAGLAPPHWVEGRGAKWDAGYEATAYFLEWIERQRGQGTVRNINAALNDRTYSNAIFRELTGSTVDELWELYRLDLKSRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IWS3</accession>
    <name>A0A2H3IWS3_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phosphopyruvate hydratase</fullName>
            <ecNumber evidence="3">4.2.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WOLCODRAFT_22675</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(2R)-2-phosphoglycerate = phosphoenolpyruvate + H2O</text>
            <dbReference type="Rhea" id="RHEA:10164"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.2.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Mg(2+) is required for catalysis and for stabilizing the dimer.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the enolase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.11" evidence="3"/>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH34406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3IWS3"/>
    <dbReference type="STRING" id="742152.A0A2H3IWS3"/>
    <dbReference type="OMA" id="RCMMSHR"/>
    <dbReference type="OrthoDB" id="1739814at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00187"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000015">
        <property type="term" value="C:phosphopyruvate hydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004634">
        <property type="term" value="F:phosphopyruvate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03313">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.10:FF:000001">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.120:FF:000002">
        <property type="entry name" value="Enolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000941">
        <property type="entry name" value="Enolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020810">
        <property type="entry name" value="Enolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020809">
        <property type="entry name" value="Enolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020811">
        <property type="entry name" value="Enolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01060">
        <property type="entry name" value="eno"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902:SF1">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00113">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03952">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001400">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00148">
        <property type="entry name" value="ENOLASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00002">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00178">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00001">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01192">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01193">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="Enolase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="Enolase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00164">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enolase N-terminal" evidence="12">
        <location>
            <begin position="3"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Enolase C-terminal TIM barrel" evidence="11">
        <location>
            <begin position="143"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="345"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="372"/>
            <end position="375"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
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        <location>
            <position position="396"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR001400-2"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR001400-3"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM01192"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM01193"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH34406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="441" mass="46857" checksum="D6D11C594DF9656B" modified="2018-01-31" version="1">MSITKIHARQIFDSRGNPTVEVDLYTEKGLFRASVPSGASTGIHEAVELRDGDKNAYVGKGVLKAVANVNDVIAPELLKAGLKVTAQKEIDDFLIKLDGTPNKGKLGANAILGVSIAVAQAGAAEKGVPLYQHLADLAGVKPPFVLPVPAFNVINGGSHAGNKLAFQEFMLLPTGASSFTEALKIGTETYHTLKKVISAKYGIDAVNVGDEGGFAPNVSGAEESLELLSEAIKKAGYEGKIKIALDVASSEFYKEGKYDLDFKNPNSDPTKWISGVELADLYLSYVKKYPIVSIEDPFDQDDWEAWTHFTANSGIQIVGDDLTVTNPLRIKTAIEKKACNGLLLKVNQIGTISESIQAAQLAQSDGWGVMVSHRSGETENTLIADLVVALGVGQIKTGAPARSERVAKYNALLRIEEEIGNGVFAGEKGLSAGLTPPALLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IX55</accession>
    <name>A0A2H3IX55_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_145364</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH34552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="222" mass="24699" checksum="F6375A7A9DB39252" modified="2018-01-31" version="1" fragment="single">MAPYQYYDEDGGGCCTTYAMHEKLSMLRIAETTMVGHCESVRRIMEIGRGMHTCGYPEKQKHSCTQKVIRYEAWDEMEVARFGNVTWLGAAQQLWGEYERSVVVGKGGAAGGGARCRERSAWALSLRGSAGAGAIEKLQKPTPHWFWPIRAAAICLISMQARHRYLPKAFLRLAAYTQHKKYPFAPTATVSRLLPLSPTNLLGSHSLLGPSFDLVHQLPAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IZ60</accession>
    <name>A0A2H3IZ60_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PARP catalytic domain-containing protein</fullName>
        </recommendedName>
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    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_145608</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467843">
        <property type="protein sequence ID" value="PCH35011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3IZ60"/>
    <dbReference type="OMA" id="ACHIGES"/>
    <dbReference type="OrthoDB" id="9514740at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003950">
        <property type="term" value="F:NAD+ poly-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012317">
        <property type="entry name" value="Poly(ADP-ribose)pol_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00644">
        <property type="entry name" value="PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PARP catalytic" evidence="1">
        <location>
            <begin position="120"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH35011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="219" mass="24801" checksum="87F51C272F1BB027" modified="2018-01-31" version="1">MTADLFITSSNIHSSSFYRTVENMFLQAWQDTRKNRPHVHAVWYINAGSQLLGRPRFSDYLNYKAQIQRQLGRNKVEEELYRGVRRACNIGDDGHHLNLCNLAECDLCRILECRYRLRNSNGTANFGTGIYTSAHSSKADDYAINAHNQSRFHVVLLSHVVTGNTYSYQSPHPQITGPPNGYQSVGAIPKRQGGTLIHPETIVYRTDAAIPSVMVVYTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IZE2</accession>
    <name>A0A2H3IZE2_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_19935</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
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        </lineage>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
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                <person name="Martinez A.T."/>
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                <person name="Yadav J.S."/>
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                <person name="Benoit I."/>
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                <person name="Ferreira P."/>
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                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4 5">MD-104</strain>
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        <source>
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        <source>
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    <sequence length="628" mass="69902" checksum="C99A4561DEA69064" modified="2018-01-31" version="1"> </sequence>
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    <accession>A0A2H3J0P8</accession>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
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        <location>
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        <location>
            <begin position="20"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="210" mass="21080" checksum="9C5B5DE668E2D2C4" modified="2018-01-31" version="1">MYALPYALTALAALTVATAKDIVITVGHNTTGNPGAVFDPQEVTAEIGDNVVFNFTLGNHTATQSTFAGPCVPAHETNSTINGFDSSFRNAGNGTAITNLNVTIDTNATIWFFDWNTCAEGGVGGININESSTQTLAGFERNAIRLNGTNTTTSTSASATATSPGSGSSTSASSTSTQSASGKSSGAERRAVAGALGAAPLVLAALALAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J184</accession>
    <name>A0A2H3J184_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal lysine N-methyltransferase 4</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WOLCODRAFT_140168</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that monomethylates 60S ribosomal protein L42.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SETD6 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="KB467865">
        <property type="protein sequence ID" value="PCH36002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J184"/>
    <dbReference type="STRING" id="742152.A0A2H3J184"/>
    <dbReference type="OMA" id="RVDWWLE"/>
    <dbReference type="OrthoDB" id="341421at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1420.10">
        <property type="entry name" value="Rubisco LSMT, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011383">
        <property type="entry name" value="N-lys_methylase_SETD6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015353">
        <property type="entry name" value="Rubisco_LSMT_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036464">
        <property type="entry name" value="Rubisco_LSMT_subst-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF34">
        <property type="entry name" value="N-LYSINE METHYLTRANSFERASE SETD6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09273">
        <property type="entry name" value="Rubis-subs-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011771">
        <property type="entry name" value="RMS1_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81822">
        <property type="entry name" value="RuBisCo LSMT C-terminal, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="6">
        <location>
            <begin position="21"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="190"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="475"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR011771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PCH36002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="502" mass="56075" checksum="643EBCE5790A9F41" modified="2018-01-31" version="1">MIPLEELLRWFQSQNGTIDGSSMGITEFPNSGRGAIALVDIPGEHTLFTIPRELTLSTRTSSLPARIGRQAWKELGLEVGWVGLILCMMWEEAQGSTSRWFSYLASLPSNFDTPMFWSEDELDELKGTAVIDKIGKSDAERDYNEKLLPAVKSRPELFLPEHIPQYYSLARYHIMGSRILSRSFHVEPWGKGGDNDSGSDASETPEGPGNPMDVDSEPLPQMNDPQDDTDDLDEDGDEEEDTENPADVAMVPMADMLNAQYGSGNVKLFYEKHDLRMVTTKPIQAGEQIWNTYGDPPNSDLLRRYGHVDLVPLPPPLSGVGNPADVVEIRADLVVVSTLKTSALDVQEKVDWWLENADDDTFVLGTDCDFPDDLVSFVRLMLLPRNEWEKTKMKSKLPKAKVDAQVLSIVKEVLERRLQEYSTTAQDDEKLLSSNAENFPLNKKHAVIVRLGEKRILHGTLGKVQASLVLMNSAPTATGKGKKRVHSDRNVETSARVKKARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J1M9</accession>
    <name>A0A2H3J1M9_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">T6SS Phospholipase effector Tle1-like catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_93984</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH33693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J1M9"/>
    <dbReference type="STRING" id="742152.A0A2H3J1M9"/>
    <dbReference type="OMA" id="RMVAMFI"/>
    <dbReference type="OrthoDB" id="3057168at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018712">
        <property type="entry name" value="Tle1-like_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840:SF1">
        <property type="entry name" value="TLE1 PHOSPHOLIPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09994">
        <property type="entry name" value="T6SS_Tle1-like_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T6SS Phospholipase effector Tle1-like catalytic" evidence="2">
        <location>
            <begin position="55"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH33693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="500" mass="55587" checksum="D48ADDBFD3332FFD" modified="2018-01-31" version="1">MSARNPRPIRRDLVSAAKKTPSSSRIRTIKQQRTSTYPMPSTGVAKQGMHLRVQKRIVVCCDGTWQDGIAVDERWKYTNVLRLSRAIRHVDTRSDPSVLQVLFYQSGIGSGNSYYDFLVDGATGATLGDKVQEAYAFIAQNFQPGDEIFLFGFSRGAFTARTIASFIGEIGVLDRVEMDHFAEIFIALQKRGQLEDGSDEKKALEEKLAPWIGPDAPGKKRACSSPNGFSIKCVGVFDTVGSVGLPEEITRKHANMKALFGFRNNNLGAHIQYAFHALAMNERREDFNCAKFEQTPEGRAKGQILKQCWFSGCHSDIGGGYHEHDLADLTLAWMAANIECLLALDDKYLTTLPNPVAPWGELPPHNSLVGIFELATTIQRKLPSATDDITHETIHPSVFQQKTFDPKLQRYLQENHHLMCSLLPLEEELKINWTVKKRPDTGDAKASSEIRLSEAGKAADAPKKTVIDIAYSDLVKKYQEQARKEWAAGSSIAAFAKALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J2F0</accession>
    <name>A0A2H3J2F0_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_166865</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
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                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
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                <person name="Wiebenga A."/>
                <person name="Young D."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
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                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH36560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="80" mass="8964" checksum="4145CE75C54EF0AA" modified="2018-01-31" version="1">MLAGNLPRTIERLSLRDGEWHAGIPQTVFLPLSAFTSFRRLTLDDVIFPSMTDSSAHLRHAKRPLVPRLGLRNEQGAGEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
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                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
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                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
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                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
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                <person name="Stenlid J."/>
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                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:ribonuclease III activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:structural constituent of ribosome"/>
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            <end position="238"/>
        </location>
    </feature>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF14622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="280" mass="30699" checksum="7E1AF8A0EBCFB9AF" modified="2018-01-31" version="1">MYKSVGRAAWSSRIPAARHPRLPPGVKVQLRSFSVAHEPQQSSSSSSLHDTRAPVPSRERVIPVRNPNDIGDLEHHLNSLFPPLKFPPELAARVLTHASHPEAIFRSSNRLSFIGRRVLQTYLHLFISGSPALEPEHDFGLIAVRAVNPYVLGEYVAPKWALGRVLRWTPVAGQLAGSEAAKDEDARGILERFGPDRSRSVGLYKVMGTTVEALVGAVYHQFGGAVAHRFFHTRILPNILLPGNPEGLNDAFHQHAMEVCAKMGGPNGPLLVSQRKTSPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J489</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Blanchette R.A."/>
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                <person name="Martinez A.T."/>
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                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
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                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
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                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
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                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="3052633at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH34593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="128" mass="14229" checksum="121DADE73B002FD7" modified="2018-01-31" version="1">MHLSALCSLLLRDGTFYFFSLLDLSLAELLLHVQLDENFGTSRTYFIAPLAPILIARFLLNLRMLPLVQGLGSQELSYDQSISELPSIEFASRMLGNIGAPLDDGLSDASDWENRADSDEDEDEDESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J498</accession>
    <name>A0A2H3J498_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WOLCODRAFT_20871</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. ROCO subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB467909">
        <property type="protein sequence ID" value="PCH37016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J498"/>
    <dbReference type="STRING" id="742152.A0A2H3J498"/>
    <dbReference type="OrthoDB" id="163438at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF261">
        <property type="entry name" value="ZINC FINGER CONTAINING PROTEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NACHT" evidence="4">
        <location>
            <begin position="225"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="425"/>
            <end position="673"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PCH37016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="691" mass="77274" checksum="50410E4D497BA16B" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J4A8</accession>
    <name>A0A2H3J4A8_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Golgi apparatus membrane protein TVP23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WOLCODRAFT_64120</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Golgi membrane protein involved in vesicular trafficking.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Golgi apparatus membrane</location>
            <topology evidence="2 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the TVP23 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH33579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J4A8"/>
    <dbReference type="STRING" id="742152.A0A2H3J4A8"/>
    <dbReference type="OMA" id="WNCRNVS"/>
    <dbReference type="OrthoDB" id="2151161at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008564">
        <property type="entry name" value="TVP23-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13019">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13019:SF7">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05832">
        <property type="entry name" value="DUF846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PCH33579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="244" mass="26688" checksum="B62718BE5733A9D5" modified="2018-01-31" version="1">MTSVSTPLLQTIEPDDPIEQPVPSGNINAASRTPVVLTPGAHASEPMASTPGDAESGSIAGIFRQSAHPLALFCLYLFRIAAILVYLLCGFFTSNFVISTVAVVILLAMDFWNCRNVAGRILVGLRYWNQVDEDGESYWVFESRDPSRPANPIDSKMFWTALYAFPLLWLALFIVSLLKFNVSFIPIVILALIFNVSNAIGFTYADRDAKQRWANSLSSGWGMGGFGAQILSGVVKNSVGRVFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J5U4</accession>
    <name>A0A2H3J5U4_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_140810</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="181" mass="18972" checksum="C8FCEFA3C38AF29B" modified="2018-01-31" version="1">MVRPRFNRNNRPNANCPVLPAVLAPHTNDARPEPVVDGACPGGAHQVAPAHGNNALPPAAAAGPVEGAVQAGAIPAISATRIPLKKGEYATMENIFKMSDAARGSVSNKDIASFLYAVGFVDNRSKGNGSARGAKHTATGDTIHIHIHRGTPSAGVVNRLRRDLEDNFHWSAESFVEATST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J6U0</accession>
    <name>A0A2H3J6U0_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_146605</name>
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    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
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                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="92"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH37365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="288" mass="29969" checksum="548CBEB85E7C6792" modified="2018-01-31" version="1">MQLVSPPGGDGGGGGGGGGGGGGDGDLSGEGRQMAGVECGFGIFSHLVQGSPSHTADGKWVVNDHYEDCTREQAAGKGLKPGVPVGEPQDTSALASEAAAPGAEAGSRVEKADYSGSGMEMYHARGATTIFGGSGWGPFAVEPRRVERGELNVRHRATEADRERARLRKEVVKTCRDILKESSEGERGRARCLALGRRRAAYEGVGQTCSQPDCGGSRSLMMDRRGACSGARRQGVVLGWALAWVDPDMKLPRDSIDEEDAPAWAHLMHIAGAAAPAELDIGCPTQVS</sequence>
</entry>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH35613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="95" mass="11305" checksum="7612ED79F63A1C88" modified="2018-01-31" version="1">MDEPEYSQNAEENLQETVSALRKDVCPHLNELLSNQDYEKLCNIDFVIWTRPDEVMPDAARWRTLLEAEMPKLYERGVLRTRVDVQLGLWNEDYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J786</accession>
    <name>A0A2H3J786_WOLCO</name>
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        <submittedName>
            <fullName evidence="5">Phosphotyrosine protein</fullName>
        </submittedName>
    </protein>
    <gene>
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            <taxon>Agaricomycetes</taxon>
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            <taxon>Phaeolaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="PCH37791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="742152.A0A2H3J786"/>
    <dbReference type="OMA" id="RTMEGFM"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR010569">
        <property type="entry name" value="Myotubularin-like_Pase_dom"/>
    </dbReference>
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        <property type="entry name" value="PH-GRAM_MTMR6-9"/>
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        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PHOSPHATIDYLINOSITOL-3,5-BISPHOSPHATE 3-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06602">
        <property type="entry name" value="Myotub-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21098">
        <property type="entry name" value="PH-GRAM_MTMR6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51339">
        <property type="entry name" value="PPASE_MYOTUBULARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myotubularin phosphatase" evidence="4">
        <location>
            <begin position="122"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate" evidence="2">
        <location>
            <position position="368"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="262"/>
            <end position="265"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="287"/>
            <end position="288"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="368"/>
            <end position="374"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR630564-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR630564-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PCH37791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="644" mass="72686" checksum="D13E55BA7F561E65" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J7A5</accession>
    <name>A0A2H3J7A5_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_136065</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH38142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J7A5"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH38142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="127" mass="14630" checksum="977D70D2455CD61C" modified="2018-01-31" version="1">MGICITTKWRECSLNYSRQLQMLETAILFQLLRINRVGGALDRSIQVNTHLLRRVLQCHSVSPDFHAATMNRSQCMSELLRAICGECCVRSDYFYRVGIPNGEYCILWFSPIERPLTGGPSRWCIML</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J7E0</accession>
    <name>A0A2H3J7E0_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_148811</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH37851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J7E0"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH37851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="407" mass="43575" checksum="2904B93B1822E78C" modified="2018-01-31" version="1">MCEGAAGARGPAVLVPHLRVRPRETVLCCCTSPPPACTSSAPACTSPTPACTPRPPARTPRVLARWRPQRPQHASRRGSKSNMAGVAANGGLRCACHRRVASVTSRSSHHSFPRVTVTARGRAGPTAASQPGTQQRAGEIAQSYQMSPRMRRHEAAFAAHTSTSSASAPELAIPGATIAACPIPSQHTHTRATDASAFPPRHRARRRVPLRSTRRDARPRIASQAGARPRTQRPVHHSTLHSWSLSPARSRGRVRARRIHSRPIPFGARPGTPELPRVPGWPRRQICRPGFAAEDAARPGSTSAWSADAVQDIDVAYDIKRGVSKVGPRTPSGNTASTSATRPRVALLSTRICRNRDSAGRRNSDQSLIPGPHHPPCITVPGQDQVMRPQTPAASPGSESSYATERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J7G4</accession>
    <name>A0A2H3J7G4_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">NADH-cytochrome b5 reductase</fullName>
            <ecNumber evidence="17">1.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">WOLCODRAFT_22092</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>2 Fe(3+)-[Dph3] + NADH = 2 Fe(2+)-[Dph3] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:71231"/>
            <dbReference type="Rhea" id="RHEA-COMP:18002"/>
            <dbReference type="Rhea" id="RHEA-COMP:18003"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83228"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:71232"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46680"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 16 17">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.2" evidence="17"/>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH33578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J7G4"/>
    <dbReference type="STRING" id="742152.A0A2H3J7G4"/>
    <dbReference type="OMA" id="VQIFMCG"/>
    <dbReference type="OrthoDB" id="432685at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090524">
        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NADH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000032">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000019">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        </location>
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            <end position="1064"/>
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            <end position="173"/>
        </location>
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            <end position="207"/>
        </location>
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            <end position="269"/>
        </location>
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            <end position="521"/>
        </location>
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            <end position="631"/>
        </location>
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        <location>
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            <end position="798"/>
        </location>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH33898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="1104" mass="118279" checksum="15491A4511666894" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J926</accession>
    <name>A0A2H3J926_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aspartate aminotransferase</fullName>
            <ecNumber evidence="7">2.6.1.1</ecNumber>
        </recommendedName>
    </protein>
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        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 7">
            <text>L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:21824"/>
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            <dbReference type="ChEBI" id="CHEBI:16810"/>
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        </reaction>
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    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
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        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3 7">Homodimer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="7">In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
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        <property type="entry name" value="Asp_trans"/>
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        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
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        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
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        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
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        <property type="entry name" value="PRK09257.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879:SF55">
        <property type="entry name" value="GLUTAMATE OXALOACETATE TRANSAMINASE 1, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00799">
        <property type="entry name" value="TRANSAMINASE"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        </location>
    </feature>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH38125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="414" mass="45662" checksum="8168B11CC6682618" modified="2018-01-31" version="1">MSVAAETWESVPLAPPDAIYKLTGAYKEDAYPQKVNLGVGAYRDDNNKPWILPVVKKATDILLNDPALDHEYLPITGLPEFTSAAARLVLGADSPAIAEGRVASVQTISGTGANHLGALFLSRFYHWPEGTEKQAYLSDPTWINHFQIMRGVGITPITYPYYDPATIGLAFGAYLATIRAAPPGSVFVLHACAHNPTGVDPTRAQWTQICELVLERKHYVFFDSAYQGFASGDLDADAWAVREFVKRGVPLLICQSFAKNAGLYGERVGALHVVAPTQETAVRIKSQLSVLTRSEISSPPAHGARLMALIMNDAALFEEWKRDIKTMAQRIIAMRKELHRLLTEELKTPGNWDHIVNQIGMFSFTGISQEQSQALIEQAHVYLTTNGRISMAGLNSHNIRYFADCLDRVVRGQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J9A6</accession>
    <name>A0A2H3J9A6_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WOLCODRAFT_167639</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467943">
        <property type="protein sequence ID" value="PCH38820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J9A6"/>
    <dbReference type="STRING" id="742152.A0A2H3J9A6"/>
    <dbReference type="OrthoDB" id="2796195at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF1">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="453"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="3">
        <location>
            <begin position="75"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="420"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="502"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="571"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="503"/>
            <end position="515"/>
        </location>
    </feature>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
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                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
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                <person name="Kuo A."/>
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                <person name="Larrondo L.F."/>
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                <person name="Ling A."/>
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                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
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                <person name="Sabat G."/>
                <person name="Salamov A."/>
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                <person name="Stenlid J."/>
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                <person name="Sun S."/>
                <person name="Syed K."/>
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                <person name="Wiebenga A."/>
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                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
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            <dbReference type="DOI" id="10.1126/science.1221748"/>
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            <strain evidence="2 3">MD-104</strain>
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</entry>
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            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Barry K."/>
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                <person name="Benoit I."/>
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                <person name="Copeland A."/>
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                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
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                <person name="Foster B."/>
                <person name="Gaskell J."/>
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                <person name="Heitman J."/>
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                <person name="Igarashi K."/>
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                <person name="Kallen N."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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    </evidence>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Martinez A.T."/>
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                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
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                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
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                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
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                <person name="Hori C."/>
                <person name="Igarashi K."/>
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                <person name="Kallen N."/>
                <person name="Kersten P."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="entry name" value="Nmd3_N"/>
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        <property type="entry name" value="NMD_SH3"/>
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    <dbReference type="InterPro" id="IPR048898">
        <property type="entry name" value="OB_NMD3"/>
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    <dbReference type="PANTHER" id="PTHR12746:SF2">
        <property type="entry name" value="60S RIBOSOMAL EXPORT PROTEIN NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12746">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY PROTEIN 3"/>
        <property type="match status" value="1"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="5 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nmd3 N-terminal" evidence="9">
        <location>
            <begin position="14"/>
            <end position="242"/>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
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    <name>A0A2H3JBJ6_WOLCO</name>
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        <recommendedName>
            <fullName evidence="9">Histone H4</fullName>
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        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
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    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
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                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
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                <person name="St John F."/>
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                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
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                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">MD-104</strain>
        </source>
    </reference>
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        <text evidence="1 9">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
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        <subcellularLocation>
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        <text evidence="4 9">Belongs to the histone H4 family.</text>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
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        <recommendedName>
            <fullName evidence="12">RING-type domain-containing protein</fullName>
        </recommendedName>
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        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
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                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
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                <person name="Ferreira P."/>
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                <person name="Gorecki P."/>
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                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
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                <person name="Kuees U."/>
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                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
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                <person name="Martin R."/>
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                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
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                <person name="Sabat G."/>
                <person name="Salamov A."/>
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                <person name="Stenlid J."/>
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                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD-104</strain>
        </source>
    </reference>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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        <property type="entry name" value="TRIAD_supradom"/>
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        <property type="entry name" value="Znf_RING"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="1"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="4"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PCH33327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="226" mass="24925" checksum="E330E28D9F909E63" modified="2018-01-31" version="1">MFECGVCFDETSEEEVAIVEPCGHQFCRECVKSHAVSKIDEHRYPIPCPTCMTGAAQEDTGVINDALIQQLGISERQYAIFVEMQMAAFSLKVRCRKCENEFFVDKAEYEAADTVRCPLGCNFTWCKACSQAIDTEPGAAAHSCDGENELKHLMGEKGWKNCPGCSTPSEKISGCNHMTCPAPGCNVHFCYHCGEQIIRSTTQEDISNALGAHYARCALWIEGQDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JBQ8</accession>
    <name>A0A2H3JBQ8_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WOLCODRAFT_86734</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH33387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JBQ8"/>
    <dbReference type="STRING" id="742152.A0A2H3JBQ8"/>
    <dbReference type="OMA" id="QMFICQL"/>
    <dbReference type="OrthoDB" id="5399138at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF2">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="142"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="256"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="293"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="317"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="1"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PCH33387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="448" mass="47869" checksum="8AD2930C75A40C4B" modified="2018-01-31" version="1">MSQFKEHFSKTGSLSATIQGLIVSTVLITASVASIISGPLSDRISRTRTISLGGIVYAAGSAISCSSNTLAQLFVGRAVAGAGEGLFLSAITVYAVEIAPTSARGRLGSMVQLLNTIGIASGYFICYGTVHIPSSLSWRFPFGMQAVVSVVLAIGAPMLPHSPRWLIHVGRHAEAQIAWAKLGVVSADAHKTNENLRRDDAAKSNWWQEAKQLWKSGIRLRTALGVFLMGMQQASGIDGVLYYAPVLFSQAGLSETTASFIASGISGIIIVVCTCFVQFYADKWGRRSSMVRGGAVIGTAMILIGTIYASHASDKPAGRWAIVVLIYVFVVGYATSWAIVTRIICSEIQPMRTRAAATSLGQCANWVVNWTVAFTTPLFLARSASGPYFLFGSCSLLTTVVCLAFQPETRGASLEDVDKAFAELPWRILVAFGSKKTLIMTPAQRTTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JC11</accession>
    <name>A0A2H3JC11_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pkinase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WOLCODRAFT_80093</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB467843">
        <property type="protein sequence ID" value="PCH35208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JC11"/>
    <dbReference type="STRING" id="742152.A0A2H3JC11"/>
    <dbReference type="OMA" id="YAHAFSI"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF110">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="49"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PCH35208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="328" mass="36421" checksum="9A3AF13212E8469B" modified="2018-01-31" version="1" fragment="single">MPAIAPDSPPRAPPIKYQTPLGTRWQKEKAAAGQGAFDYPDDAKYVGPWIIGECVGKGASGHVKIAKHRKTGQLAAAKILPLPPAQQAKSEKQRLGIDREITMMKLMNHPNIMRIYDVYEGEKELYLILEYVEGGELFDFLVNRGKLAPLEALAYFKQIVYGLNYAHTFSIIHRDLKPENILIHSLNPPLIKIADWGMAAFAPPSLQLETSCGSPHYASPEIVNGHKYCGTATDIWSCGVILYALLTGRLPFDDKNVRNLLSKVKVGKYEMPTYIDPLAKDLLSRMLVVEVSKRITMAEILTHPWLEGQTPGITYVPAPPVSELARPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JC66</accession>
    <name>A0A2H3JC66_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Aspartic peptidase A1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WOLCODRAFT_141138</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467965">
        <property type="protein sequence ID" value="PCH39175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JC66"/>
    <dbReference type="STRING" id="742152.A0A2H3JC66"/>
    <dbReference type="OMA" id="NDSEYPA"/>
    <dbReference type="OrthoDB" id="660550at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013608229" evidence="5">
        <location>
            <begin position="23"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="6">
        <location>
            <begin position="74"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PCH39175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="401" mass="42239" checksum="101B9A82262EA1F6" modified="2018-01-31" version="1">MAVISLRTLVVLAVASASVANAVTKLALDPVKGRTGAYMQGAPDADRARAKLQKSRGSSDATTIPATNLAYVQYTASIGVGSPATYYNLVVDTGSSNTFVGTGKKYVKTKTSIPTGQEVNVTYGTGYFSGYEYLDQVTIASGFVITNQSIGDALEYADFEGVDGIIGVGPIDLTLGTLYPDVNAEIPTVMNNALEQGLISTEVLGVSFAPADLYSDTNGVLTFGGIDSSLYIGDIAYTPVTATEPAGYYWGVNVTGATYGATTVIPGSYAGIVDTGTTLIYIADNWYSTYQASIPGAYYDSEDTGLIVIPESSVASLKNFTFQIGGAEYVLDSTAQLLPQDQNTAWGGKPGLQYGYIGPLGSNSGEGLDFIIGQKFMERFYAVFDTANERVGFAYTDHTFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JCN6</accession>
    <name>A0A2H3JCN6_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_159237</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468031">
        <property type="protein sequence ID" value="PCH39651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JCN6"/>
    <dbReference type="STRING" id="742152.A0A2H3JCN6"/>
    <dbReference type="OMA" id="MQVYERV"/>
    <dbReference type="OrthoDB" id="420564at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35179">
        <property type="entry name" value="PROTEIN CBG02620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35179:SF2">
        <property type="entry name" value="START DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH39651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="157" mass="17967" checksum="82C7D479F5CAC84B" modified="2018-01-31" version="1">MFTAIWSVLRHNVGAVDDSVSTPELDVIRAGTRVPQSSVIEMCTRSCRNAEQFDLVDAFPQLYFSQAPNHYLAVHSRGEFETITKKHLDNPDMKRIEASAQSGFKKLKRTLQDIQELVIEHGQRGRLSLVHRDGQLRVFERISQTDCIPEQLLSRFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-05-03" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JD01</accession>
    <name>A0A2H3JD01_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_29572</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467998">
        <property type="protein sequence ID" value="PCH39445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JD01"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH39445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="152" mass="16944" checksum="35813C988B5B67EB" modified="2018-01-31" version="1">MLVLPVSRAIKEGVAEIAAFLIDEKNKAREPLLQRIGDVERELAAVREAHTEANQRASNVQAQLQDKTAELDRVRAELQTTLQLLEERRALIQNLEKERDELASAARAQEAPPPLSDDKNDDVMMSDEAPEPILNPEGGFPESRVRAQLSKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JDF7</accession>
    <name>A0A2H3JDF7_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_135874</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH37843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JDF7"/>
    <dbReference type="OMA" id="THIPGAY"/>
    <dbReference type="OrthoDB" id="3256525at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013897636" description="F-box domain-containing protein" evidence="1">
        <location>
            <begin position="28"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH37843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="431" mass="48315" checksum="84434671EFEA0621" modified="2018-01-31" version="1">MPASANLPVELWLIILSIATHIPGAYDCNNEHAVACFVEDEDGICLRRLHREATNTILSACLVCKAWAEISNEFLFRYLLVLDGAHAIRIASALGNSGPKSASSDSPGRWTRRLELAMEGVHIWTQEHKRALIRIFRSCPKLTVFSTAFCTSDVYLWQYLGLAHVVCNGLQGSRLRRLELKYDSALLRTLLPHLAPTLEVVWVLPPIDRRTAGHPEQCTFALPKVHTLAISYQNLWTTEWTVPTLRTVIAGHDRDVCSSSPLTSFLRIHGAKVRHLVARPEERASRSHESILTLCPNVVDWTTPEEGTYLQILEDRPTCPSLRLLTVDVSSVMRLPLVCRILYASLATAGTFASLKCIRLRLPLPRAECSPPFQPGGFGFRCCEDLLEVCCRRGILVEVSLGMEEHFADCWRPFSVETLFPQNAALHRSVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JDP7</accession>
    <name>A0A2H3JDP7_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WOLCODRAFT_117137</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB468053">
        <property type="protein sequence ID" value="PCH40360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JDP7"/>
    <dbReference type="STRING" id="742152.A0A2H3JDP7"/>
    <dbReference type="OMA" id="ESIDTPW"/>
    <dbReference type="OrthoDB" id="2309723at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF29">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="6">
        <location>
            <begin position="42"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PCH40360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="477" mass="51892" checksum="7D33A844772A9220" modified="2018-01-31" version="1">MSTSSRGSAESAITASKQALRNILTPLSALPEPSAATVQILINTFFQHADQVGFFLHRGWFMRLLSARSIHPQQQAISPALLNALYLWGVRLATLDTLLLYEPVFLSRATQALAGTVAHMPSYSITHTIQAEILLANFHFASGQLAQARHHCSAATALALSCRLHQVRSIQLPRTNPIHAMEFNPPPPADVTEEAERIQAFWQVFILDACLAVPSRLPSRFVGSHGAQVDTPWPLDAEAYEQGGFPSGIRGSSTVEAFLRGTDLNPYHGSSSVALHAKAAALFERAADMASRFLTATDTEQFAAEFVALDSIIDHFSNSLMPVNMSAGLDATRRLLVTHTLARVATIQLHQRLREMEALTESKDVSAAKAAASLLDGVSMGQVGYISPILGLLWSIVARVLHSEMTRLRSLWMSASTFGHQSSNAQQLRYMQEEHDKVAAALAKVCNAMSSLASTSSYMAMQAEICRREMMQAGTGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JDP9</accession>
    <name>A0A2H3JDP9_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_166500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="PCH35808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="742152.A0A2H3JDP9"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411:SF3">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411">
        <property type="entry name" value="FAMILY ATPASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase AAA-type core" evidence="1">
        <location>
            <begin position="21"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH35808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="203" mass="22805" checksum="2F655D34C13A45BD" modified="2018-01-31" version="1">MSEELRKPLYIVGAADLGTNAESLDNNLTRVFKVAATWGAVCLIDEADVFLEERSLQFIERNAMVAVFLRQLDPSTHRYFRGILLLTTNRVRVFDEALQSRIHISIRYSDLTPEVRRQIWLAFLRKVNGDVSNGGVTEEELAELGEKDVNGRQIKNVVKMAGALAAEEFTQRIKLAENTKLANDVIMPVEKEGESTPSDPKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JEC3</accession>
    <name>A0A2H3JEC3_WOLCO</name>
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        <submittedName>
            <fullName evidence="4">Nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WOLCODRAFT_96617</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH38163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="742152.A0A2H3JEC3"/>
    <dbReference type="OMA" id="TMSIYEN"/>
    <dbReference type="OrthoDB" id="6593433at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
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        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43119">
        <property type="entry name" value="ABC TRANSPORT PROTEIN ATP-BINDING COMPONENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43119:SF1">
        <property type="entry name" value="ABC TRANSPORTER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="3">
        <location>
            <begin position="6"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PCH38163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="241" mass="26541" checksum="AA4710BC9A93097E" modified="2018-01-31" version="1">MTETVLEVNDLQCSRAKGDPVFSHVNFKVNAGDIVVVQGRSGSGKSTLLKCLSHMNIYSGEILYRGKTPKSYGIPHYRTRVLYVPQRASLLPGTPRDFMEAISNFGSYNKKSSAERSQSARPRGLSHETIELAEEWGIDEELWDRSWSNLSGGEMQRIALAIAVGMKSAEVMLLDEPTSALDPDSSASVENYLRSQIKASDSNLKALVWVTHSEEQGRRVGNRFMQLSAGGIQEESVDSGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JF74</accession>
    <name>A0A2H3JF74_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WOLCODRAFT_99040</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD-104</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468053">
        <property type="protein sequence ID" value="PCH40541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="742152.A0A2H3JF74"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="CYP_FUM15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013722856" evidence="10">
        <location>
            <begin position="26"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="492"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PCH40541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="555" mass="62019" checksum="29BE9855FCF7CE62" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JFC1</accession>
    <name>A0A2H3JFC1_WOLCO</name>
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        <recommendedName>
            <fullName evidence="10">Autophagy-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WOLCODRAFT_137074</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
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                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
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                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD-104</strain>
        </source>
    </reference>
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        <text evidence="10">Vacuolar effluxer which mediate the efflux of amino acids resulting from autophagic degradation. The release of autophagic amino acids allows the maintenance of protein synthesis and viability during nitrogen starvation.</text>
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    <comment type="subcellular location">
        <subcellularLocation>
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        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ATG22 family.</text>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Atg22"/>
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    <dbReference type="InterPro" id="IPR024671">
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    </dbReference>
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        <property type="entry name" value="ATG22/LtaA_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519:SF4">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATG22"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <keyword evidence="4 10" id="KW-0926">Vacuole</keyword>
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        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="167"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="321"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
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            <end position="408"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="420"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="487"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PCH40922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JH53</accession>
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        <submittedName>
            <fullName evidence="5">Calcium activated cation channel</fullName>
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        <name evidence="5" type="ORF">WOLCODRAFT_137050</name>
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        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
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                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
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            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD-104</strain>
        </source>
    </reference>
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        <property type="component" value="Unassembled WGS sequence"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR35859">
        <property type="entry name" value="NONSELECTIVE CATION CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="LHD_TRPY1"/>
        <property type="match status" value="1"/>
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    <feature type="transmembrane region" description="Helical" evidence="2">
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            <end position="211"/>
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        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
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        <source>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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        <source>
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    </evidence>
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        <source>
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        <source>
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        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
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        <recommendedName>
            <fullName evidence="2">CCD97-like C-terminal domain-containing protein</fullName>
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    </protein>
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            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468113">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040233">
        <property type="entry name" value="CCD97-like_C"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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            <begin position="135"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH41512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="233" mass="26987" checksum="761EF81F3E1BFDAE" modified="2018-01-31" version="1">MSAVSRILSYLGLPNDYTPSPDAQPIEFLSRHLRQLPPHLLSHFSSTTTPKQRSVIPAIRNRRLRYADSNPPQLRLSAAKATWPTLWPGREPPGREQGEDERAWAEKFFMGSLKPHVGKLGMLLGGYEEERESERVRSIRRAQAEALESLPEEDESSDEDGEEQPLEEEESPEDVQSWFIRRIREQFIYGLLESTDYDKVDWDDTWDTDNDRDAEERWFDDEEESDVPPGLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JHC0</accession>
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        <recommendedName>
            <fullName evidence="2">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">WOLCODRAFT_137102</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
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                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH40955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JHC0"/>
    <dbReference type="STRING" id="742152.A0A2H3JHC0"/>
    <dbReference type="OrthoDB" id="2792702at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="DUF6534"/>
    </dbReference>
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        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="2">
        <location>
            <begin position="258"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH40955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="378" mass="42706" checksum="82610BBE28A8CBD3" modified="2018-01-31" version="1">MLRHNLCAGVVLLPSLSRRSHMVEASGNVKQKYIQSNSNIFKQCSGGSPLALGWSRRSLKLGCRTYVPFQFIARSQRWQTQTLWCYLMLRPNTPIELVIINWNKFGNPDSIGRNIGPSFVVEFVVTTVSTFIVHSYYAHTVWKTTPLAWYRQPLAMSLLALAFSSFGTGIGELLRYFTFILRRCLPTEYDICGNPNQYVSLLAWRSRKCLDMARVTVLCQIATIGNHIMYHLFSAAVIKCSFNAMVVQTLSFAQMVLAALMDVLTTISLCYNLRQGQTGFHSTKSMLRKLTLYIINRGILVALAQLAQIVTFEIFYSYPTSPPYVRLVFQFIGSKLYVNTMLALLNARRHLRCAGGSTLDLDDIFSSNNSAEDVVHCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JHG7</accession>
    <name>A0A2H3JHG7_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 5B</fullName>
            <ecNumber evidence="3">3.6.5.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Translation initiation factor IF-2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">WOLCODRAFT_24889</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
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                <person name="Lindquist E."/>
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                <person name="Lombard V."/>
                <person name="Lucas S."/>
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                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
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                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
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                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.3" evidence="3"/>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH41640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="742152.A0A2H3JHG7"/>
    <dbReference type="OMA" id="EFAVMLC"/>
    <dbReference type="OrthoDB" id="4928at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03703">
        <property type="entry name" value="aeIF5B_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01887">
        <property type="entry name" value="IF2_eIF5B"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="eukaryotic translation initiation factor 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Eukaryotic translation initiation factor 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Eukaryotic translation initiation factor 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000112">
        <property type="entry name" value="Eukaryotic translation initiation factor 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10050">
        <property type="entry name" value="Translation initiation factor IF- 2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029459">
        <property type="entry name" value="EFTU-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
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    <keyword evidence="11" id="KW-0342">GTP-binding</keyword>
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            <begin position="409"/>
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            <begin position="1"/>
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            <begin position="63"/>
            <end position="72"/>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00032478"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00048107"/>
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        <source>
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        <source>
            <dbReference type="PROSITE" id="PS51722"/>
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        <source>
            <dbReference type="EMBL" id="PCH41640.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
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    <sequence length="1245" mass="135102" checksum="A65700078BB169B6" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JHP9</accession>
    <name>A0A2H3JHP9_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">tRNA pseudouridine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WOLCODRAFT_108373</name>
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    <organism evidence="9 10">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD-104</strain>
        </source>
    </reference>
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        <reaction evidence="4">
            <text>a uridine in tRNA = a pseudouridine in tRNA</text>
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            <dbReference type="Rhea" id="RHEA-COMP:13934"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the tRNA pseudouridine synthase TruA family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:pseudouridine synthase activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
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    </dbReference>
    <dbReference type="CDD" id="cd02568">
        <property type="entry name" value="PseudoU_synth_PUS1_PUS2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="tRNA pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, C-terminal subdomain"/>
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        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, N-terminal subdomain"/>
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    </dbReference>
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        <property type="entry name" value="hisT_truA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142:SF4">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PseudoU_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pseudouridine synthase I TruA alpha/beta" evidence="8">
        <location>
            <begin position="178"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="376"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
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            <end position="385"/>
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    </feature>
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        <location>
            <begin position="402"/>
            <end position="411"/>
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    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="46"/>
        </location>
    </feature>
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        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00009375"/>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF01416"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="423" mass="47662" checksum="5C72369D40B7A783" modified="2018-01-31" version="1">MQIQPDPKLRTIEGVLFNALVEVGAVSRDNADDPVKVGLGRAARTDAGVHAAGNVVSMKLITAVPGVADLVARINEVLPPEIRLWSILRAQNAFNARTTCDSRKYTYFFPSYLMIPPKPGSGLHGNLRQNDSDVPPHAFWASLSGNEGESIETSHEEDLRRKRTYRMPAEQVEALRAAARKFEGSHNFHNFTVGRDFRDRSCVRHMISIKIADPVVYGDTEWVNVLFHGQSFMLHQRKMMSALVLACRTGSPPEIIEEIYGPRMIFVPKMPALGLLLEYPIFDTYTRKVSSVNEKLQPSDSEYRPPIDFELHREAIDEFKQQHIYTRMRAIEGQEGVFDAWIRSIDSYSGNDLLYLNSKGIIPAAAVIKKGERRPNPFREKRRFDATSFTADGGAESKPVAEDEEDEEGEEQLDRAKLNDMEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JHQ3</accession>
    <name>A0A2H3JHQ3_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Extradiol aromatic ring-opening dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WOLCODRAFT_87994</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD-104</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DODA-type extradiol aromatic ring-opening dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH38289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JHQ3"/>
    <dbReference type="STRING" id="742152.A0A2H3JHQ3"/>
    <dbReference type="OMA" id="SVIDGFW"/>
    <dbReference type="OrthoDB" id="7396853at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07363">
        <property type="entry name" value="45_DOPA_Dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.830.10">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014436">
        <property type="entry name" value="Extradiol_dOase_DODA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004183">
        <property type="entry name" value="Xdiol_dOase_suB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30096">
        <property type="entry name" value="4,5-DOPA DIOXYGENASE EXTRADIOL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30096:SF0">
        <property type="entry name" value="4,5-DOPA DIOXYGENASE EXTRADIOL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02900">
        <property type="entry name" value="LigB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006157">
        <property type="entry name" value="Doxgns_DODA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53213">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Extradiol ring-cleavage dioxygenase class III enzyme subunit B" evidence="6">
        <location>
            <begin position="36"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PCH38289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="321" mass="34902" checksum="061677A4BB4F21DA" modified="2018-01-31" version="1">MSNTDGINASLPRTQAEWRKALEELPSTPGNIPAFFFGHGSPFLAFPESDAHGGNPVVDHMGPKGPLATFLKDFGPALLRKYKPQGIVVFSAHWETVGERVVTDYGDSNPLLMDYYGFQPALYKLKFDSRGDSALSQRIVELYKQVGHPARTTSKLEPRGEDGRGFSGPGLDHGVFVPFRLMFGEEFREVPIVQVSIDGSLSPEKNWAAGKVVEQLRREGILVLAGGLMVHNLRDFSSFAEESAGKLVKDFDRAILDAVPVPDPQARKEAMVNLTRHPGFRAAHPRAEHFVPLYVAAGAGGDGGVKVLSAIYGSPTFAFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JHQ5</accession>
    <name>A0A2H3JHQ5_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">WOLCODRAFT_83915</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">MD-104</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467920">
        <property type="protein sequence ID" value="PCH37258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JHQ5"/>
    <dbReference type="STRING" id="742152.A0A2H3JHQ5"/>
    <dbReference type="OMA" id="GCPFDPF"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="452"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PCH37258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="526" mass="59480" checksum="D8010048D52A11CA" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JI61</accession>
    <name>A0A2H3JI61_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_21053</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467931">
        <property type="protein sequence ID" value="PCH37418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JI61"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH37418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="190" mass="21148" checksum="7C1637E2AAF9CE12" modified="2018-01-31" version="1">MPGTSNDVCDAGNRPRARHCSEVVASAITVEGEIDEEQTPTTKPAEGLSQETARIGVFWRKLRQLQGLLEWRSHCEKPTGRRTAARRPNMYMSTVCASSSEAIILSSIRIMRDRALYNLSLRTRLLTGDSWSSRSWAQQAKSQDTSVPGTVRDEADLLRAIYQAPTGALSEVCYVDGTGPLYQARTWAKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JIG0</accession>
    <name>A0A2H3JIG0_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_73034</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468124">
        <property type="protein sequence ID" value="PCH41980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JIG0"/>
    <dbReference type="STRING" id="742152.A0A2H3JIG0"/>
    <dbReference type="OMA" id="PESACIC"/>
    <dbReference type="OrthoDB" id="3228837at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="2">
        <location>
            <begin position="34"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH41980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="229" mass="25567" checksum="F2D5D6FB70AF99FE" modified="2018-01-31" version="1">MPTDAQAIFSKLPHCDHAEYRSTINEAKNGYLQGTCTDLLSCLMHWATASEQPCIFILSSAVGTGKSTVVFELAKWLDRNGCLGASFFFVHGDADLSCTTYVIPTITYQLAQSQTYLHSCIIEHASFHLSRGDLQNMEAQVQDLITQPLSDITEDCDPVVVIINALDECADQALEHVPRLLYLLLRGIRGLHIPIHVLLTTCPELHIEHAFKTVEFQSIMKPYHLEEVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JJ12</accession>
    <name>A0A2H3JJ12_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Trafficking protein particle complex subunit 2-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_137443</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAPP small subunits family. Sedlin subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH41525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JJ12"/>
    <dbReference type="STRING" id="742152.A0A2H3JJ12"/>
    <dbReference type="OMA" id="FHYIVHC"/>
    <dbReference type="OrthoDB" id="18320at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14854">
        <property type="entry name" value="TRAPPC2L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006722">
        <property type="entry name" value="Sedlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044760">
        <property type="entry name" value="TRAPPC2L"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12403">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04628">
        <property type="entry name" value="Sedlin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH41525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="176" mass="19458" checksum="CA24A1718A4114BA" modified="2018-01-31" version="1">MPPQLRLNAVAFVSPQNHPILIRTFGQARQDELRYHYIAHTSLDVIEERIAAAQAAKSTECYLNLLYTMEDVAVYGYVTPLRVKIIAALALTDAVVRDVDVVTVFQALHTAYRLAVANPFHKLNTPLEGVNDHAAMLAAGGARMPAFRRRVDDIGRALGAPVPVSPPYPPQRQLHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JKB0</accession>
    <name>A0A2H3JKB0_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_28560</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467876">
        <property type="protein sequence ID" value="PCH36437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JKB0"/>
    <dbReference type="OrthoDB" id="2787798at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013608231" evidence="2">
        <location>
            <begin position="20"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="57"/>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
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                <person name="Barry K."/>
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                <person name="Martinez A.T."/>
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                <person name="Yadav J.S."/>
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                <person name="Benoit I."/>
                <person name="Boyd A."/>
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                <person name="Hori C."/>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
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                <person name="Nagy L.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Kallen N."/>
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                <person name="Kohler A."/>
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                <person name="Kuo A."/>
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                <person name="Nagy L.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
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    </evidence>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
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                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
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                <person name="Benoit I."/>
                <person name="Boyd A."/>
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                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
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                <person name="Foster B."/>
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                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
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                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
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            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
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    </reference>
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    <dbReference type="Proteomes" id="UP000218811">
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        <location>
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            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH39869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="212" mass="23980" checksum="0DA42DB904089950" modified="2018-01-31" version="1">MEANSCERPPQPTATPPPLPPARIFTNHREILEAVQPDLSQPVRYTDCRVLTRYPGAIQDGNDYYVSSPNMNFVPQLPIHDPTRKFGYFADGMLGPFELTKWPQTYDQIEPHLLATPCNPGIIAKLETPLVDEAHKLWQYEDPQAAWFPFTHTDVQVSASVLSADVGTLRTSVVQRLQHAVMEACAVVEVVISKHYPTQEKDPYETKVWKVK</sequence>
</entry>
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                <person name="Martinez A.T."/>
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                <person name="Yadav J.S."/>
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                <person name="Benoit I."/>
                <person name="Boyd A."/>
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                <person name="Ferreira P."/>
                <person name="Findley K."/>
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                <person name="Glotzer D."/>
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                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
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                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
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                <person name="Sabat G."/>
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                <person name="Wiebenga A."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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                <person name="Kallen N."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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                <person name="Martinez A.T."/>
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                <person name="Yadav J.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">MD-104</strain>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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    </dbReference>
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        <location>
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        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="93" mass="10845" checksum="ABB1F85E05A5B4F9" modified="2018-01-31" version="1" fragment="single">RGVSSSPYGRTHVWKHRQKKMPKPFVPQFPQRVIRADGSTFTHYTTSPRSSVRLTRDTTNNPVWNAAKWMAENEEEDVITGRLGRFNRRFDGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
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    <name>A0A2H3JMV3_WOLCO</name>
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        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
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        <name evidence="3" type="ORF">WOLCODRAFT_138394</name>
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    <organism evidence="3 4">
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                <person name="Riley R."/>
                <person name="Barry K."/>
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                <person name="Barry K."/>
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            <strain evidence="2 3">MD-104</strain>
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</entry>
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            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Patyshakuliyeva A."/>
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                <person name="Young D."/>
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                <person name="Eastwood D.C."/>
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    <sequence length="689" mass="76698" checksum="4D198FC68C2F32D2" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JQX7</accession>
    <name>A0A2H3JQX7_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycoside hydrolase family 5 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WOLCODRAFT_26848</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468157">
        <property type="protein sequence ID" value="PCH44552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JQX7"/>
    <dbReference type="STRING" id="742152.A0A2H3JQX7"/>
    <dbReference type="OMA" id="WMLPAEW"/>
    <dbReference type="OrthoDB" id="1887033at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF42">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013857301" evidence="5">
        <location>
            <begin position="20"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="6">
        <location>
            <begin position="78"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PCH44552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="465" mass="51246" checksum="56303F05B42615AB" modified="2018-01-31" version="1">MHVLVSLVALLASAYNVLAGSMPSKIYGVNIGGWLVLEPWMLPAEWEEMGGQICDDCSDCIMSEWAYTKAYPYKANTEFANHWSTWFTQDDVNELVADGINTARMQLGFWIVEPLVDRATEFYPEGGIVYLQQGVKMLKDAGIQVILDHHALPGVQTGDQSFTGNCTENVQFYTDYNYQRALVWTAVMTSLSHLDPNFDSVFAIEAVNEPIMDADETPDYGTFQYEFVDTVRAVELTLGIPVPGLSLDVQVSTTNFTEALGQVANASTIFNPNVRAALATAAPILVELSVQLSVPALLNTDLASGLPSRTTLLTTFMDVNWQYNDPPNPANAAIGPQGYDNHLYYSYGGVAAANPTAYMESICNLDRVQADAAVGDSPLWFGEWGLPTQFNATDEFLYMWADAQKLAYSKGAGWIFWNFKVEQSELAGNLSRQWSYIEGVKLGFLTQDPSQYHNASVCAPYVSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JR04</accession>
    <name>A0A2H3JR04_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">laccase</fullName>
            <ecNumber evidence="5">1.10.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">Wclcc2</name>
        <name evidence="18" type="ORF">WOLCODRAFT_165246</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4 hydroquinone + O2 = 4 benzosemiquinone + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11276"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17594"/>
            <dbReference type="ChEBI" id="CHEBI:17977"/>
            <dbReference type="EC" id="1.10.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.10.3.2" evidence="5"/>
    <dbReference type="EMBL" id="KB468157">
        <property type="protein sequence ID" value="PCH44576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JR04"/>
    <dbReference type="STRING" id="742152.A0A2H3JR04"/>
    <dbReference type="OMA" id="HAHIADQ"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052716">
        <property type="term" value="F:hydroquinone:oxygen oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046274">
        <property type="term" value="P:lignin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13856">
        <property type="entry name" value="CuRO_1_Tv-LCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13903">
        <property type="entry name" value="CuRO_3_Tv-LCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000045">
        <property type="entry name" value="Laccase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000112">
        <property type="entry name" value="Laccase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF511">
        <property type="entry name" value="LACCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0186">Copper</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0439">Lignin degradation</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013816814" description="laccase" evidence="14">
        <location>
            <begin position="24"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="17">
        <location>
            <begin position="35"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="15">
        <location>
            <begin position="166"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="16">
        <location>
            <begin position="372"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PCH44576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="523" mass="57070" checksum="90D061B240859F01" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JRN1</accession>
    <name>A0A2H3JRN1_WOLCO</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="1" type="ORF">WOLCODRAFT_15997</name>
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        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="742152.A0A2H3JRN1"/>
    <dbReference type="OrthoDB" id="2735520at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH38667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="226" mass="25305" checksum="60C3F4FE530B65D6" modified="2018-01-31" version="1">MPYQQLYDLAYSPPGYPTCSAPAFAPVSSFYELTRASPYAQDLPRRDEAEAIVLQDRQATRGHFWPHGKGISGWAYVPQRSYIPQSPYNPVTILEYKVNGKVGILLSDACNRRFEGLEQRDDLAFTSIPGQKASLRILWPGYQQDFSCQFNVKDARKNVQSISVAKSAHEIACKTKKALDMYTLYTCNDAAWKIGPGHIGLNQLLLVRVVQVSKAGIQPVFCVSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JRS2</accession>
    <name>A0A2H3JRS2_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Endonuclease</fullName>
            <ecNumber evidence="10">3.1.30.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">WOLCODRAFT_136405</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MD-104</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the DNA/RNA non-specific endonuclease family.</text>
    </comment>
    <dbReference type="EC" id="3.1.30.-" evidence="10"/>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH38707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="742152.A0A2H3JRS2"/>
    <dbReference type="OMA" id="YVMPNQV"/>
    <dbReference type="OrthoDB" id="5418055at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006309">
        <property type="term" value="P:apoptotic DNA fragmentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00091">
        <property type="entry name" value="NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.570.10:FF:000008">
        <property type="entry name" value="Probable NUC1-dna/rna non-specific nuclease, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.570.10">
        <property type="entry name" value="Extracellular Endonuclease, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018524">
        <property type="entry name" value="DNA/RNA_endonuclease_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044929">
        <property type="entry name" value="DNA/RNA_non-sp_Endonuclease_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001604">
        <property type="entry name" value="Endo_G_ENPP1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020821">
        <property type="entry name" value="ENPP1-3/EXOG-like_nuc-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040255">
        <property type="entry name" value="Non-specific_endonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13966:SF5">
        <property type="entry name" value="ENDONUCLEASE G, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13966">
        <property type="entry name" value="ENDONUCLEASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01223">
        <property type="entry name" value="Endonuclease_NS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00892">
        <property type="entry name" value="Endonuclease_NS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00477">
        <property type="entry name" value="NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="His-Me finger endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01070">
        <property type="entry name" value="NUCLEASE_NON_SPEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 10" id="KW-0540">Nuclease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA/RNA non-specific endonuclease/pyrophosphatase/phosphodiesterase" evidence="13">
        <location>
            <begin position="81"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="ENPP1-3/EXOG-like endonuclease/phosphodiesterase" evidence="12">
        <location>
            <begin position="82"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR640255-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR640255-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PCH38707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="342" mass="37244" checksum="13E235AECF5FE4FB" modified="2018-01-31" version="1">MPGVSIVHAAFFAVGALVGGGVATAVSASRRQGSPMPAQPQQPVLDVKQGGITQIQGSSAVSIQSPVLKYGNPGPVSDQLVRLAYVAGYDRRLRHPVWTAEHLTLASLGKSPLEPPKSGTGDRQNSTFSEDQSIPELFRAKLQDYFRSGYDRGHMVPAADAKMSQAAMDETFLLTNIAPQVGVGFNRHYWAYLEDWCRRLTSTFSDVYVFTIPLYLPKLDPDGKWRVTHEVIGSPPNVAVPTHFAKVVLTSKPSSPSTPHIPEISTGAFVLPNASIPDEAKLESFVVPIEAVERAAGLTLFSDAIKQSSKHICKTTKCEVIVRRFDDAQKRPEMRRAISAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JRV1</accession>
    <name>A0A2H3JRV1_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_139135</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468168">
        <property type="protein sequence ID" value="PCH44671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JRV1"/>
    <dbReference type="OrthoDB" id="7464126at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF14">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="2">
        <location>
            <begin position="6"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH44671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="350" mass="40200" checksum="93EB10E9A29A9DA6" modified="2018-01-31" version="1" fragment="single">MQASPDEAVVYFFCDSKDNSKRTSDTIVRALMVQLLETKSAYWQDYHLLRDDILKRGRSYKFSVRELEKYLTSLTKSFTKTRFIIDGLDECEREVLEDQGVIAMLDRLVNSSDCRTKILLFGRAEKQVQERLSSWPQLEIGGTGTTQDDMRTYVSRKVDELTGHIPYLVGRREALQEQLLRASGAMFLFARLLVQALIENKDLPRNDIESMLNRPPHDLNCMYAQYLDNLARRNNSARVHQIGCQVLQWLVYSDGPISLTLLDATLAISPEDDRMHPDKRLGDVQAVIQRALGILVEYRQALDSSWRASLVHQSFKDYLTDVDHGDLNASPTYSLNIRSMLQSHVAHFHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JS00</accession>
    <name>A0A2H3JS00_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_77748</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468168">
        <property type="protein sequence ID" value="PCH44721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JS00"/>
    <dbReference type="OMA" id="IIPDREH"/>
    <dbReference type="OrthoDB" id="421671at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025638">
        <property type="entry name" value="DUF4336"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33835:SF1">
        <property type="entry name" value="METALLO-BETA-LACTAMASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33835">
        <property type="entry name" value="YALI0C07656P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH44721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="237" mass="26753" checksum="B92A499DE986F8A2" modified="2018-01-31" version="1" fragment="single">KVARGVWMFSCPFSRFGVIPFGGRSTAIKLSNGDVWVLASTPLTDETKQKLDELGPVRWIIGADAVHHLYLSAFKQQYPDAKLIAVKEAMGKKSTEGLKFDGAWGADPPDTKYGFEDDIKHCFFSGFVNKDVAFFHPASKTLIEADLLFNLPPTEQYSKTGSSGRIPIFGTLSPYQWIHKRFVYSLGTDKEQATSLPHRDVRTVVGWDFERIIPCHGDVIEKDGNKAWREAYKWYLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JSB2</accession>
    <name>A0A2H3JSB2_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Alpha-mannosidase</fullName>
            <ecNumber evidence="3">3.2.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WOLCODRAFT_25560</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Degrades free oligosaccharides in the vacuole.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides.</text>
            <dbReference type="EC" id="3.2.1.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 38 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.24" evidence="3"/>
    <dbReference type="EMBL" id="KB468135">
        <property type="protein sequence ID" value="PCH42793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JSB2"/>
    <dbReference type="STRING" id="742152.A0A2H3JSB2"/>
    <dbReference type="OMA" id="GQYWDAW"/>
    <dbReference type="OrthoDB" id="10261055at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004559">
        <property type="term" value="F:alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009313">
        <property type="term" value="P:oligosaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10812">
        <property type="entry name" value="GH38N_AMII_ScAms1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.50:FF:000004">
        <property type="entry name" value="alpha-mannosidase 2C1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.110.10:FF:000002">
        <property type="entry name" value="alpha-mannosidase 2C1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.30:FF:000001">
        <property type="entry name" value="alpha-mannosidase 2C1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.110.10">
        <property type="entry name" value="Glycoside hydrolase 38, N terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.50">
        <property type="entry name" value="Glycoside hydrolase family 38, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.30">
        <property type="entry name" value="Golgi alpha-mannosidase II, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054723">
        <property type="entry name" value="Ams1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041147">
        <property type="entry name" value="GH38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011682">
        <property type="entry name" value="Glyco_hydro_38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015341">
        <property type="entry name" value="Glyco_hydro_38_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037094">
        <property type="entry name" value="Glyco_hydro_38_cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000602">
        <property type="entry name" value="Glyco_hydro_38_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027291">
        <property type="entry name" value="Glyco_hydro_38_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028995">
        <property type="entry name" value="Glyco_hydro_57/38_cen_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46017">
        <property type="entry name" value="ALPHA-MANNOSIDASE 2C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46017:SF1">
        <property type="entry name" value="ALPHA-MANNOSIDASE 2C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09261">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22907">
        <property type="entry name" value="Ams1-like_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17677">
        <property type="entry name" value="Glyco_hydro38C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07748">
        <property type="entry name" value="Glyco_hydro_38C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01074">
        <property type="entry name" value="Glyco_hydro_38N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00872">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88688">
        <property type="entry name" value="Families 57/38 glycoside transferase middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 38 central" evidence="9">
        <location>
            <begin position="560"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00054985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00071615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PCH42793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="1142" mass="127756" checksum="EEC3BC95F136BE68" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JSF2</accession>
    <name>A0A2H3JSF2_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphoglycerate mutase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WOLCODRAFT_139298</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468168">
        <property type="protein sequence ID" value="PCH44871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JSF2"/>
    <dbReference type="STRING" id="742152.A0A2H3JSF2"/>
    <dbReference type="OMA" id="SWPPFTS"/>
    <dbReference type="OrthoDB" id="10257284at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF110">
        <property type="entry name" value="2-PHOSPHOXYLOSE PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00778">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013642040" evidence="3">
        <location>
            <begin position="25"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PCH44871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="508" mass="56081" checksum="1094FD5891B3A3D6" modified="2018-01-31" version="1">MNCELTVVLRLLSLLLVALSCSQSAVFSLQTYMVIPEGGGPTKVTTAGDSSGRTKLGHVPLDVDGYPVAPPELELEQVHIYVRHGERTPVGVRMADPPASLPKHWMFCHTARNFHAAVASGSRMVPGAPLVAGQDGGTGEEESLRTIRIVERADGTAMLGECLLGELTDVGRQTTYDFGHALRQLYIDRLSFLPDIAKSNNEIYLRSTNVPRTVESLQQVTHGLYPETKSGAGFVPVVRIRNGKDENLFGNTLVCKRLEALQLGFAKAAAAEWNETLASLDVKLSKYIGGNPVRLDGKPRASGILDTIRAADAHGVNVPKEFREPGVMDLIEKAVVHEWFADKTEEVRRLGMGPLLSDLARKMQAKIEGSMQDPLKILIHSTHDTSLAALCSTLDVFDNRWPAFSSAVTFELFRRHNQSRMQPTVWQNVLAPFRRQRSDTSSEFYVRLRYQNRNLPLPACAPEGKHLPGSPEFCTFAAFRERVQELTPLDWEAECATTRGSPERTSNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JTI9</accession>
    <name>A0A2H3JTI9_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WOLCODRAFT_139305</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclin family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468168">
        <property type="protein sequence ID" value="PCH44885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JTI9"/>
    <dbReference type="STRING" id="742152.A0A2H3JTI9"/>
    <dbReference type="OMA" id="PACSKNQ"/>
    <dbReference type="OrthoDB" id="5590282at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20568">
        <property type="entry name" value="CYCLIN_CLBs_yeast_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000001">
        <property type="entry name" value="G2/mitotic-specific cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048258">
        <property type="entry name" value="Cyclins_cyclin-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00292">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 4" id="KW-0195">Cyclin</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="7">
        <location>
            <begin position="402"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="8">
        <location>
            <begin position="495"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="7">
        <location>
            <begin position="499"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="72"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="279"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="627"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="114"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="288"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="320"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PCH44885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="668" mass="74534" checksum="2184E5FCCC094099" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JU32</accession>
    <name>A0A2H3JU32_WOLCO</name>
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        <recommendedName>
            <fullName evidence="2">RecQ-mediated genome instability protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WOLCODRAFT_120512</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RMI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468124">
        <property type="protein sequence ID" value="PCH42409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JU32"/>
    <dbReference type="STRING" id="742152.A0A2H3JU32"/>
    <dbReference type="OMA" id="FLEPKCV"/>
    <dbReference type="OrthoDB" id="341511at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031422">
        <property type="term" value="C:RecQ family helicase-topoisomerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.770">
        <property type="entry name" value="RecQ-mediated genome instability protein Rmi1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049363">
        <property type="entry name" value="RMI1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042470">
        <property type="entry name" value="RMI1_N_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013894">
        <property type="entry name" value="RMI1_OB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14790:SF15">
        <property type="entry name" value="RECQ-MEDIATED GENOME INSTABILITY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14790">
        <property type="entry name" value="RECQ-MEDIATED GENOME INSTABILITY PROTEIN 1 RMI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08585">
        <property type="entry name" value="RMI1_N_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21000">
        <property type="entry name" value="RMI1_N_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01161">
        <property type="entry name" value="DUF1767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RMI1 N-terminal" evidence="5">
        <location>
            <begin position="13"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="RecQ mediated genome instability protein 1 OB-fold" evidence="4">
        <location>
            <begin position="70"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="220"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="396"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="446"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="226"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="237"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
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            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
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        <location>
            <begin position="398"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="447"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="502"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="515"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF21000"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH42409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="574" mass="62021" checksum="125D42E318A4C357" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
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                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
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            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH39907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
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    <name>A0A2H3JV85_WOLCO</name>
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        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
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                <person name="Nagy L.G."/>
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                <person name="Ohm R.A."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH40067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="270" mass="30481" checksum="9702955B5A40D5D0" modified="2018-01-31" version="1">MSATMAGGPSSPLLRSCVVEGTRPQPSHTSTLMATRDNRSALSLFRDYISPDLDNFVLQVALRHGDCVDVDEDVGPGLVDALCHALSSNHELYEPFMKIFKSPELSSYMEEAIPADVKDEIVAHYRQLGLVNGGPDPYRDAVAHYHGCHELHEETEDMVCSSPEIYDDTNASDVIGSQSDAYSEEVTMSDDDRVNAETKQPAFVEHRFLTDNAEECLDWDQEMADGRSEIMRIRRVASDSELWRWQCKCRIRVSNRFRKDLRCVLCNRSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
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    <name>A0A2H3JVY5_WOLCO</name>
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        <recommendedName>
            <fullName evidence="3">HPt domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WOLCODRAFT_67973</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD-104</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:histidine phosphotransfer kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043424">
        <property type="term" value="F:protein histidine kinase binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AHP1-5/YPD1"/>
    </dbReference>
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        <property type="entry name" value="HPT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008207">
        <property type="entry name" value="Sig_transdc_His_kin_Hpt_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28242">
        <property type="entry name" value="PHOSPHORELAY INTERMEDIATE PROTEIN YPD1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HPt" evidence="3">
        <location>
            <begin position="99"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="42"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphohistidine" evidence="1">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PCH40317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="218" mass="23979" checksum="C1BF589126BB1F35" modified="2018-01-31" version="1" fragment="single">PPPSSSSSPPPPPSPRRRQRQGRPPPASPPSRPRRATRRPPSSRPPPTSPPTTPMPRTIRCVPAPRRLPIAAHPAQADASDTIDMETFHQILDLDEDDTHDFSKGMAWAYFTQASTTFVEMDEAYTKKDLAKLSSLGHFLKGSSAALGVARVQASCEQIQHFGQLRDEAAGTDLDARAALARIGPLLTRVKHEYATAEAWLKKWYRDNAEPTSEDEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JWY4</accession>
    <name>A0A2H3JWY4_WOLCO</name>
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        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WOLCODRAFT_137871</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="PCH42368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OMA" id="VIMDMAY"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS"/>
    </dbReference>
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        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF15">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="269"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="314"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <begin position="346"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <begin position="377"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="414"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="451"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="35"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PCH42368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="484" mass="52799" checksum="DC772087C543493E" modified="2018-01-31" version="1">MSPARERSESPDEETALLSGAKGEPKRITPLPYLQIYILLLLQLAEPITSQCIYPFINQLVSELDITGGDERKVGYYAGLIESLFFMTEAMFVLQWSRVSDYIGRKPVLLTGMVGLCISMVFFGLSRTFWQLVVSRCIVGALNGNIGVIKSMMGELTDSTNMAQGFALMPVVWSAGATVGPFIGGQLAKPHDRWPQVFTSRFWMRFPYFLPCAVSASFSAFTFIIAAIFLKETVKKKPKKKSVRIVVEVDDGARLQEEPLENPATLRSLMVWPVLLSVANYGCLALLDIAYRAIQPLFYSTPIALGGLGLSPARIGAVLGAFGLMNGVFQAMFFARVVRRFGPKAVFMTGMAVFIPLYVLFPVINALARSAGMITPLVWAIVFLQLGISVIMDMSYGCVFIFITSSAPNKRSLGATNGIAQLVAAIVRAFGPASATSLFALSLEENWLGGYAVYAILVVVACALISVSVPLPREAWTKEDVRGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K0H6</accession>
    <name>A0A2H3K0H6_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_151961</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468124">
        <property type="protein sequence ID" value="PCH41927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K0H6"/>
    <dbReference type="STRING" id="742152.A0A2H3K0H6"/>
    <dbReference type="OrthoDB" id="2437251at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH41927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="79" mass="9108" checksum="B1CE811BBF92D4E9" modified="2018-01-31" version="1">MVYSFSCAQSLRRMDRFDCGGWLHVALSHQPQEALIRLKHDEQHIAYTDIELPDYWKDYMSQFGICGIARAQDGVAMAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K0P7</accession>
    <name>A0A2H3K0P7_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL30m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WOLCODRAFT_25441</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL30 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468124">
        <property type="protein sequence ID" value="PCH42584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K0P7"/>
    <dbReference type="STRING" id="742152.A0A2H3K0P7"/>
    <dbReference type="OMA" id="THFRITQ"/>
    <dbReference type="OrthoDB" id="509901at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01658">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.20">
        <property type="entry name" value="Ribosomal protein L30, ferredoxin-like fold domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036919">
        <property type="entry name" value="Ribo_uL30_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005996">
        <property type="entry name" value="Ribosomal_uL30_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016082">
        <property type="entry name" value="Ribosomal_uL30_ferredoxin-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01308">
        <property type="entry name" value="rpmD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15892:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL30M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15892">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00327">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55129">
        <property type="entry name" value="Ribosomal protein L30p/L7e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL30-like ferredoxin-like fold" evidence="6">
        <location>
            <begin position="63"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="32"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="124"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="32"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PCH42584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="151" mass="16368" checksum="CDA2E2318D638FAC" modified="2018-01-31" version="1">MWSTTTLSASTSLRTCACSRLLVRTLATAAPSSSSAESTAHASTSTSTPPTPSASAPEPPTHFRITQRRSAIALPARYKATLVALGLHRRLQTVYHPYSADIAGKILRVKELVQVENVPASAVRTKTEQRRERRPPRGYAVVGSRMRDADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K1Z2</accession>
    <name>A0A2H3K1Z2_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 12">Lon protease homolog</fullName>
            <ecNumber evidence="7 12">3.4.21.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">WOLCODRAFT_144351</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Hydrolysis of proteins in presence of ATP.</text>
            <dbReference type="EC" id="3.4.21.53"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7 10 11">Belongs to the peptidase S16 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="7 12"/>
    <dbReference type="EMBL" id="KB468135">
        <property type="protein sequence ID" value="PCH43054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K1Z2"/>
    <dbReference type="STRING" id="742152.A0A2H3K1Z2"/>
    <dbReference type="OMA" id="ICTANTM"/>
    <dbReference type="OrthoDB" id="2411602at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19500">
        <property type="entry name" value="RecA-like_Lon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000021">
        <property type="entry name" value="Lon protease homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.5270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004815">
        <property type="entry name" value="Lon_bac/euk-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054594">
        <property type="entry name" value="Lon_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003111">
        <property type="entry name" value="Lon_prtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008268">
        <property type="entry name" value="Peptidase_S16_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10046">
        <property type="entry name" value="ATP DEPENDENT LON PROTEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22667">
        <property type="entry name" value="Lon_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02190">
        <property type="entry name" value="LON_substr_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001174">
        <property type="entry name" value="Lon_proteas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00830">
        <property type="entry name" value="ENDOLAPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00464">
        <property type="entry name" value="LON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51787">
        <property type="entry name" value="LON_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51786">
        <property type="entry name" value="LON_PROTEOLYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01046">
        <property type="entry name" value="LON_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 7 10" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 10" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Lon N-terminal" evidence="15">
        <location>
            <begin position="6"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Lon proteolytic" evidence="14">
        <location>
            <begin position="726"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="256"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="393"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="268"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="402"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="active site" evidence="8 10">
        <location>
            <position position="821"/>
        </location>
    </feature>
    <feature type="active site" evidence="8 10">
        <location>
            <position position="864"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="464"/>
            <end position="471"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00050665"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRNR" id="PIRNR001174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001174-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001174-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PCH43054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="932" mass="102169" checksum="01406C22477DCC75" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K4H9</accession>
    <name>A0A2H3K4H9_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_153392</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="PCH43337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH43337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="260" mass="28580" checksum="65E39558A6F2BC07" modified="2018-01-31" version="1">MAFIKIVNQVTESVEEPDVNNQYDWEGAQTPDIDNIDSLCPLKRTWQQMKDIKVGTKRSEPRLTEQRIIKVTVPNGAKRSHPDPNMKFLNPAAKSGQKSRWSTWCHLDDSDDGEDTNDEGGSQPKKRRIASMPNGHSDSSPSPEVADIDMDDAPSALVTKPMEVVEPPSQPSTPASPAVSTPTPDPILCPAIMPLLPSPIIYSSSSSHIGQLFMHNSYVPCKPSKLCTSFTIDQDSEEVTDSHQEHDSTMAHTPVPQLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K692</accession>
    <name>A0A2H3K692_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Salicylate hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WOLCODRAFT_105356</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD-104</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="PCH44584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="742152.A0A2H3K692"/>
    <dbReference type="OMA" id="WPRAWNV"/>
    <dbReference type="OrthoDB" id="417877at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051104">
        <property type="entry name" value="FAD_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720:SF3">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="4">
        <location>
            <begin position="5"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="4">
        <location>
            <begin position="304"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PCH44584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="444" mass="48816" checksum="272758D57CFF25EA" modified="2018-01-31" version="1">MSPKFTVAICGGGVGGLTCAVALSRYPDIQVNIYEAASKFAEVGAGIGMWPRAWKVMDALGLSTELSNVAISAPVHEPKVAFTFRQGDQPIGRSFYTLITPGGMTTLHRPEFQSVLLKHVPPSCRMHTSKRLVSYTQPPSDTRRSGHSPAPIVLRFSDGSSATCDLLIGADGVKSNVRAGLVRELASDAAAQGRTREAEELRRAAHPLWSGTRTYRATIPAEVLRARLPGHRVLTEPMIYFGKDTQLTCYPIARGTIINFAAMRARYDLENTILDGPWIDDAPREELLQDFSRWEPEVQALFQSVPRYSRWAIHTTQRLPSFVSGRIALIGDAAHAMMPYQGAGAGQAIEDGYLLATLLGHRKTTLPTLVRALRIYDELRRPFAQRVAETSRENGLLYTLNHPALARGAGLDAAAARIRDNWAWAWETTIDGDVDRALRMLEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K779</accession>
    <name>A0A2H3K779_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Clavaminate synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_77315</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468157">
        <property type="protein sequence ID" value="PCH44297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K779"/>
    <dbReference type="STRING" id="742152.A0A2H3K779"/>
    <dbReference type="OMA" id="CHEVALT"/>
    <dbReference type="OrthoDB" id="406156at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="2">
        <location>
            <begin position="180"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH44297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="351" mass="39061" checksum="083DDF69E1525955" modified="2018-01-31" version="1">MPGLIAQPPFPEDVPTHPLLVVDYQLIRAKDENEVNKLWNAATQLGFWYLKNHGVDNEVNAMFEMGAETMALPLEEKMKFEQGDDGMSFGYKAAGVNAVDEKGNLDSTEFINVSKDDALAYPVTVHRNYPATVVARMETTIKPFVQKSLEVNGTLLSVLNDKLGLPERTLAHLHRNEERSGCVARVIRTPPKDEAFDEERALLSAHTDFGSLSFLHNRLGGLQVLAPGTDKWQYVKPLPGHAICNVGDSLHIFSGGILRSNVHRVIPPPGEQAKFERYSLVFFTRASDGTELRALTDRSDLIAEAVAKAANAAERFRPGVTAQEWLARRVRNQRIKHFEVSSADCSFDPRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K988</accession>
    <name>A0A2H3K988_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_155020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468168">
        <property type="protein sequence ID" value="PCH44997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K988"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH44997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="170" mass="18305" checksum="5B5A9ADC9EE25A57" modified="2018-01-31" version="1">MSADGGSCTAHGRLASLRRRVGPVHGRAAAPQCVGAVAKAACASARASLIRRRLPESGHRHLRRNIDRSSHAQARGFSRASRADDRLKRDPRGSRRSGGRTHRMLTRGRRGARQSPELKLKCGTSAPEASPTSVSDPRRAAAEYGAGVRARARLRGAMRARRRTGACERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3ISU7</accession>
    <name>A0A2H3ISU7_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_159812</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH33062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3ISU7"/>
    <dbReference type="STRING" id="742152.A0A2H3ISU7"/>
    <dbReference type="OMA" id="HTHESME"/>
    <dbReference type="OrthoDB" id="2535105at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="2">
        <location>
            <begin position="173"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH33062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
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            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
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                <person name="Benoit I."/>
                <person name="Boyd A."/>
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                <person name="Ferreira P."/>
                <person name="Findley K."/>
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                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
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                <person name="Kuo A."/>
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            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Benoit I."/>
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                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
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                <person name="Heitman J."/>
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                <person name="Jurgens J.A."/>
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                <person name="Larrondo L.F."/>
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                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
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                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
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                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
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                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH33181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3ITZ2"/>
    <dbReference type="OMA" id="YQFTQGF"/>
    <dbReference type="OrthoDB" id="3352450at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH33181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="92" mass="10061" checksum="8BD7CECB342023B8" modified="2018-01-31" version="1">MTFTRQPPQEARRDGLFAGLSAALAGAILGNKLFRFNRNTTIVCGGVTGVLSGYQFYQGFLASNLARLRAEQAKRQQSESVFGEDLSANKFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IWR8</accession>
    <name>A0A2H3IWR8_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WOLCODRAFT_135551</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD-104</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH34181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3IWR8"/>
    <dbReference type="STRING" id="742152.A0A2H3IWR8"/>
    <dbReference type="OMA" id="RSMIDHA"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03753">
        <property type="entry name" value="proteasome_alpha_type_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000015">
        <property type="entry name" value="Proteasome subunit alpha type-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033812">
        <property type="entry name" value="Proteasome_alpha_type_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003075">
        <property type="entry name" value="PRK03996.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 5 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="7">
        <location>
            <begin position="8"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PCH34181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="242" mass="26839" checksum="7AF925CB946D6B07" modified="2018-01-31" version="1">MFLTRSEYDRGVNTFSPEGRLFQVEYAIEAIKLGSTTVGVKTREGVVLGVEKRVQSPLLESSSIEKIMEIDTHLGCAMSGLTADARTMIDHARVTSQNHAFVYDERIKVESVTQAVCDLALRFGESVHDEDAMMSRPFGVALLIGGIDELGPQLYHTDPSGTFVRYEAKAIGSGSEAAQSELQDKWHSSMSLQEAQLLTLRVLKQVMEEKLDHHNVQLAQITPEKGFEILDEVRLKAIIDAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IWT7</accession>
    <name>A0A2H3IWT7_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Golgi SNAP receptor complex member 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WOLCODRAFT_135566</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of several multiprotein Golgi SNARE complexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the GOSR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH34201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3IWT7"/>
    <dbReference type="STRING" id="742152.A0A2H3IWT7"/>
    <dbReference type="OMA" id="QAYAVND"/>
    <dbReference type="OrthoDB" id="422156at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005797">
        <property type="term" value="C:Golgi medial cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048219">
        <property type="term" value="P:inter-Golgi cisterna vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023601">
        <property type="entry name" value="Golgi_SNAP_su1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21094:SF2">
        <property type="entry name" value="GOLGI SNAP RECEPTOR COMPLEX MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21094">
        <property type="entry name" value="GOS-28 SNARE- RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12352">
        <property type="entry name" value="V-SNARE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF027109">
        <property type="entry name" value="Golgi_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="48"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR027109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PCH34201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="223" mass="25011" checksum="9C732BDCA710E534" modified="2018-01-31" version="1">MSTYDALHRQCRTLESLFDTKLTAYARLASAMTRSQDDLEAGDSAERWRDLEAEVDELLEKLHENNDQLSALAGDAGSPPSQSMLRAIQRHREVYQDYARELRRTKTNVKSALDQANLLSGVRNDIDAYKSSAADALLAERGHIDSSHQMTDDILSQAYETRAEFSRQRTTITGINSRMAGVLNTMPGVNNLISMIKSRRRRDSIIVGCVIGICLVLLLTYIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IYP7</accession>
    <name>A0A2H3IYP7_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CRAL/TRIO domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_106178</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467832">
        <property type="protein sequence ID" value="PCH34555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3IYP7"/>
    <dbReference type="STRING" id="742152.A0A2H3IYP7"/>
    <dbReference type="OMA" id="YRQIDPF"/>
    <dbReference type="OrthoDB" id="1434354at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.20">
        <property type="entry name" value="N-terminal domain of phosphatidylinositol transfer protein sec14p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051026">
        <property type="entry name" value="PI/PC_transfer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45657">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN YKL091C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45657:SF1">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN YKL091C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03765">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="86"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH34555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="270" mass="31471" checksum="5FBE689AEA511844" modified="2018-01-31" version="1">MSSELTKDQEATLEQFRSRLAEQDLLRDGDTIGSDDFTLLRFLRARQFDVKAATTMWANCLQWRKTVQGVGIDELYKQMDPYDFPERREVFEYWPMWFHKTDKAGRPLSIQHYGGVNMPELYKLITPERFMQYIIVTAESIPREILPAASRAAGRQVEGQYLVVDLKGFSLGQFWQMKNVVRESFQIMQDYFPELMYKFIIINAPVSFTYIWSFVKLWLAKETLAKIDILGADYQNVLLKDIDRENLPVVLGGTCECEDVGGCKWCRAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IZ77</accession>
    <name>A0A2H3IZ77_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_166186</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467843">
        <property type="protein sequence ID" value="PCH35300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3IZ77"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH35300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="328" mass="35790" checksum="F1001D3AEBC159B4" modified="2018-01-31" version="1">MSERSQARPGHTDLLRATPTGPATAGSRGDAGAAQARAFWAPTSTQIAIARADWCARASPARNGGGRARRPANPIGARKISLTRWNLRRYGRRALIGCRAGAREASKALCILLGRCLVREGVPGRFPVRRWRCCRLVHRDFWRGDPTQRQGVDDSTPSALDAAAYECTEVLALRELRLQPSEYGTWLSLLHMRMPARSHEQQLPPQRKISGRKLARSTMRCASGTAARLHRGGSRFNQPPDPAGRTIAKAFEDYMQRVRAIEYHPGRVPDEVEKCPVAAIWVAGVIDLQRKADRDGTGMGKGDCTEEPGAFCGLLGGCGSASTVVCKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IZL7</accession>
    <name>A0A2H3IZL7_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_139904</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467843">
        <property type="protein sequence ID" value="PCH35422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3IZL7"/>
    <dbReference type="OrthoDB" id="2785713at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH35422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="359" mass="40667" checksum="4B1343C9B9ED872E" modified="2018-01-31" version="1">MGYFLKEHKILAILIAQLPNVQSFTMHTTSIAVIPWPQIAFRPRKLVISVGWERYHIVDVGSEMKAFDQMLALPDFWGRIEYLDVDHCENLLETAAAKNVMPLPSIRTLKIGDVRPGTLDNAARLFPDAHTLKIMLCILDNYSTEYRLASWSRLDTVTVRRGSFVSNIPTALGSHVRCLRLEADIAFSFCMTSTLPLLERTSPVVLTIRTGHPLCDAGSVSELQKCVKAAPELRFIEIEFVARAQRYEQWSQWIEITQASALRQSCLIGMLLSRMTFDAISLSRDECPMIAKGLAAQILTLQYVGFQSLEKDFPCGVIHNWSIWYRVKRKEDGGEPIIEELLPDRACSIHRELLATSRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J0P5</accession>
    <name>A0A2H3J0P5_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tripeptidyl-peptidase II</fullName>
            <ecNumber evidence="4">3.4.14.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">WOLCODRAFT_107799</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Secreted tripeptidyl-peptidase which degrades proteins at acidic pHs and is involved in virulence.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal tripeptide from a polypeptide.</text>
            <dbReference type="EC" id="3.4.14.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="15">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
            <location evidence="3">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.4.14.10" evidence="4"/>
    <dbReference type="EMBL" id="KB467854">
        <property type="protein sequence ID" value="PCH35756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J0P5"/>
    <dbReference type="STRING" id="742152.A0A2H3J0P5"/>
    <dbReference type="OMA" id="INPATTW"/>
    <dbReference type="OrthoDB" id="409122at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008240">
        <property type="term" value="F:tripeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04056">
        <property type="entry name" value="Peptidases_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11377">
        <property type="entry name" value="Pro-peptidase_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000015">
        <property type="entry name" value="Tripeptidyl peptidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015366">
        <property type="entry name" value="S53_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030400">
        <property type="entry name" value="Sedolisin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050819">
        <property type="entry name" value="Tripeptidyl-peptidase_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218">
        <property type="entry name" value="PROTEASE S8 TRIPEPTIDYL PEPTIDASE I CLN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218:SF15">
        <property type="entry name" value="TRIPEPTIDYL-PEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09286">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00944">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51695">
        <property type="entry name" value="SEDOLISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11 15" id="KW-0106">Calcium</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="10 15" id="KW-0720">Serine protease</keyword>
    <keyword evidence="8 16" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0843">Virulence</keyword>
    <keyword evidence="13" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013957747" description="tripeptidyl-peptidase II" evidence="16">
        <location>
            <begin position="18"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S53" evidence="17">
        <location>
            <begin position="214"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="15">
        <location>
            <position position="290"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="15">
        <location>
            <position position="294"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="15">
        <location>
            <position position="486"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="528"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="529"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="549"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="551"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PCH35756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="570" mass="59952" checksum="07DE9C9E86CE18C0" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J104</accession>
    <name>A0A2H3J104_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_147557</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467831">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OMA" id="KETGRIM"/>
    <dbReference type="OrthoDB" id="2752996at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0003676">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH33463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="246" mass="26631" checksum="0E32B52656730DE9" modified="2018-01-31" version="1">MPSSPLTGMLAGDGQNRAIRVGGPLQSNQIGELIGAIVVASTVPDFSPLLLVTDSTYVIDGLTIHLPHWEDRGWLGVANMHTSLLWVKGHADIEGNIQADALVGQGSRGDPPVETDLLVPTNFHLLGARLASLSQCLAYMSVHLRNATPTQLSATRSLDLAQAAIQERTGHLPNPARIWQSLWSADLSPNISDFLWKTAHNAYQVGSFWYHVSGAEERAICPVCQVDKSMEHILVYCNAPGPTTVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J1H4</accession>
    <name>A0A2H3J1H4_WOLCO</name>
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        <submittedName>
            <fullName evidence="2">Glycosyltransferase family 8 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_139936</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467854">
        <property type="protein sequence ID" value="PCH35545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J1H4"/>
    <dbReference type="STRING" id="742152.A0A2H3J1H4"/>
    <dbReference type="OMA" id="MAKPFLQ"/>
    <dbReference type="OrthoDB" id="2014201at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glyco_trans_8"/>
    </dbReference>
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        <property type="entry name" value="GNT1/Glycosyltrans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11183">
        <property type="entry name" value="GLYCOGENIN SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01501">
        <property type="entry name" value="Glyco_transf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH35545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="359" mass="40214" checksum="7F058DE59FFA2522" modified="2018-01-31" version="1">MAPLSAFRRYKDYIPLWNGHDLSTSAGKANGRRWSVGGLLVAFSVVLNLVLIWLSWRTTPTALDNYQHLNEFPLLSQDATISHASSENAIVTSLYTDAFATSVATLGHSLNKVNSSATRLLIYLPEKVSPAALCIATASGFTPHPISRIPPPHAGVHRHFLDQYSKLQLWTLGKLGVKNLVYIDADTLVRRNFDELFALPYSFAAVPDVFLDGRGFAVAFNAGVLFLRPSLDVFRDMVSKIATARYPAEDAEQSFLNHYFGKEALRLPYAYNANLAIKKRSSEMWKDLMGDARIVHYTLVKPFLQGDYAEVPIEKMEKNIQSKMGKHGGIFTDELNEWAQMWKETKELYGEAFTSCRAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J2T1</accession>
    <name>A0A2H3J2T1_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">UvrD-like helicase ATP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WOLCODRAFT_159800</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH33049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="742152.A0A2H3J2T1"/>
    <dbReference type="OMA" id="GYNICKD"/>
    <dbReference type="OrthoDB" id="3156807at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039904">
        <property type="entry name" value="TRANK1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21529">
        <property type="entry name" value="MAMMARY TURMOR VIRUS RECEPTOR HOMOLOG 1, 2 MTVR1, 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21529:SF4">
        <property type="entry name" value="TPR AND ANKYRIN REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3 5" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="7">
        <location>
            <begin position="351"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1802"/>
            <end position="1821"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="372"/>
            <end position="379"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PCH33049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="2022" mass="231344" checksum="B98F677819477282" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J2X4</accession>
    <name>A0A2H3J2X4_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WOLCODRAFT_87293</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH34123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J2X4"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:RNA binding"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:structural constituent of ribosome"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.790:FF:000001">
        <property type="entry name" value="50S ribosomal protein L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002143">
        <property type="entry name" value="Ribosomal_uL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_uL1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_uL1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023673">
        <property type="entry name" value="Ribosomal_uL1_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36427">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36427:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL1M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002155">
        <property type="entry name" value="Ribosomal_L1"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="Ribosomal protein L1"/>
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        <property type="entry name" value="RIBOSOMAL_L1"/>
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    </dbReference>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PCH34123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="274" mass="29835" checksum="1818DA760C5C12D0" modified="2018-01-31" version="1">MPSRHDTQCGQTQTKPSGRRLKVAQPTKAQLAAKERKRALKKARKNSAYASEKMTLEDAIAVLRAVEVAAPNSTYELVVKTAMIRGSTIPKGRFSLPREAKETTRDRILVFAEGKQAEEAKQAGADIVGGLELVDGVISGRYQASMFLCTPALIRAITPKLGRVLGPRGLMPSERRGTVTDNITGFIKKLKGTSEWKGDKAGAIRAPIGKLNWPIEDVVKNFRYFMTVVKRATGNQRDPDAPVDKKETGNKPPMAITKVVLSSRQGPGIQISDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J399</accession>
    <name>A0A2H3J399_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_146265</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467876">
        <property type="protein sequence ID" value="PCH36441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J399"/>
    <dbReference type="STRING" id="742152.A0A2H3J399"/>
    <dbReference type="OMA" id="TSIALCM"/>
    <dbReference type="OrthoDB" id="2536347at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="2">
        <location>
            <begin position="114"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH36441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="255" mass="27467" checksum="934FBF222CBD2844" modified="2018-01-31" version="1">MFTFECVQTGLVTAGGMQIYVYSYGNILSLIEVHNAWFALSIMCGVIASTVESFFAWRIYQLSRSRILASIIIVLALAQLVASVVSGVLEREARIAADMQGASKNAATVWLSCAAAADVLIALSMVILLLRIKSGIASTDALIDRLVRMVVETGALTAGISILVIVLAFCGSLHKTLVYETPALILTKLYSNTFLTNLNSRNYVRNHDQHVLELSRLGSRRSAPASPLEFGGRSVLLPSAVTANDTENSDTAEPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J3A5</accession>
    <name>A0A2H3J3A5_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutathione transferase</fullName>
            <ecNumber evidence="2">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WOLCODRAFT_81030</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in the oxidative stress response and detoxification.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 11">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="2"/>
    <dbReference type="EMBL" id="KB467865">
        <property type="protein sequence ID" value="PCH36185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J3A5"/>
    <dbReference type="STRING" id="742152.A0A2H3J3A5"/>
    <dbReference type="OMA" id="PYGPNPW"/>
    <dbReference type="OrthoDB" id="422574at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03048">
        <property type="entry name" value="GST_N_Ure2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.130:FF:000016">
        <property type="entry name" value="Glutathione S-transferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF3">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR URE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01151">
        <property type="entry name" value="Main.2:_Nu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
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            <end position="89"/>
        </location>
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        </location>
    </feature>
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    </evidence>
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        <source>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        </source>
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        </source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
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        </source>
    </evidence>
    <sequence length="226" mass="25961" checksum="B05AE0E6151BE9C9" modified="2018-01-31" version="1">MSHDKQFTLYTHIAGTNGWKVVFVLEELGLTYESKYLDFVKNEHKSPDHVALNPNGRIPTLIDHANKDFVVWESNAILLYLVDKYDTTHKLSAEKLEDKVTQLQWLFFQASGQGPYYGQAAWFMRQHPEKIPSAIERYRKETFRVLGVLDGVLSKQEWLVGDKCTIADLSFITWNHFAIVSFGGDSDVNIEKDFPALFKWHNALTSRESVRKCLAERDALLAAQSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J3E0</accession>
    <name>A0A2H3J3E0_WOLCO</name>
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        <recommendedName>
            <fullName evidence="2">Fungal-type protein kinase domain-containing protein</fullName>
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        <name type="common">Brown rot fungus</name>
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            <taxon>Agaricomycetes</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">MD-104</strain>
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            <begin position="412"/>
            <end position="551"/>
        </location>
    </feature>
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        </location>
    </feature>
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        <location>
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            <end position="753"/>
        </location>
    </feature>
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            <end position="308"/>
        </location>
    </feature>
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        </location>
    </feature>
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            <dbReference type="Pfam" id="PF17667"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH36481.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="753" mass="85101" checksum="0043E26274D3DF9E" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J3G2</accession>
    <name>A0A2H3J3G2_WOLCO</name>
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        <recommendedName>
            <fullName evidence="12">Cora-domain-containing protein</fullName>
        </recommendedName>
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        <name evidence="10" type="ORF">WOLCODRAFT_135642</name>
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        <name type="common">Brown rot fungus</name>
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        <lineage>
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            <taxon>Agaricomycetes</taxon>
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            <taxon>Phaeolaceae</taxon>
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    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
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                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
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                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
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                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
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                <person name="Ohm R.A."/>
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                <person name="Rokas A."/>
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                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:cobalt ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
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    </dbReference>
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        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46494">
        <property type="entry name" value="CORA FAMILY METAL ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46494:SF1">
        <property type="entry name" value="CORA FAMILY METAL ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="562"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="596"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="246"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="642" mass="73398" checksum="D5C48AAD134B27CC" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J3I9</accession>
    <name>A0A2H3J3I9_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_159494</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467886">
        <property type="protein sequence ID" value="PCH36531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J3I9"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH36531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="274" mass="29680" checksum="A4D76BD23FA5E1C7" modified="2018-01-31" version="1">MQARGDPAPPRAPSLQSTAHGSAACLTNRALGLDDPQLHPAPRAFPPGRTNAWGIASAPAPVVWATVQALGAHGGTIRLNNWDLWRCSGLTTKHPRSSVDPRGNPARAPIERGAASAAPDEDEQDAKAPDGHRTPESKRAPRRTTPAATRPFRSMVAHQRKAIRQGQPPESNRHSRKPQPPTPQRIKRKGGQRHIVAKATRRAPSRTAAPPLYQTRHPFRRPRPHAHKAGRAVRQAARQRVGRGAEHTNTPLGPATWSYHTPTASHSNRATAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J4S5</accession>
    <name>A0A2H3J4S5_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rab GDP dissociation inhibitor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WOLCODRAFT_22213</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the Rab GDI family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH33749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J4S5"/>
    <dbReference type="STRING" id="742152.A0A2H3J4S5"/>
    <dbReference type="OMA" id="FETKAKM"/>
    <dbReference type="OrthoDB" id="9446342at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005093">
        <property type="term" value="F:Rab GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.405.10:FF:000001">
        <property type="entry name" value="Rab GDP dissociation inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000158">
        <property type="entry name" value="Rab GDP dissociation inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.519.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018203">
        <property type="entry name" value="GDP_dissociation_inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000806">
        <property type="entry name" value="RabGDI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787:SF8">
        <property type="entry name" value="RAB GDP DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787">
        <property type="entry name" value="RAB GDP-DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00996">
        <property type="entry name" value="GDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00892">
        <property type="entry name" value="RABGDI"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00891">
        <property type="entry name" value="RABGDIREP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU363124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PCH33749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="448" mass="50149" checksum="58E26121ECD71540" modified="2018-01-31" version="1">MDEEYDVIVLGTGLTECILSGLLSVEGKKVLHMDRNDYYGGDSASLNLTQLYRKFRPDQSAPAELGRDRDYAVDLIPKFIIASGELTRILVHTDVTRYLEFKQIAGSFVYRDGKISKVPSTEMEAVKSPLMGLFEKRRAKKFFEFLQGWKDDDPATHQGVDLDKDSMKSVYEKFGLEPGTQDFIGHAMALYLDDDYKTKPARTTYERIVLYTSSMARYGKSPYIYPLYGLGELPQAFARLSAIYGGTYMLDKSIDEIVTDADGKFVGVRSGNETVKAKQVVGDPSYFGAGKPAEGKARVKEEGKVIRAICFLKHPIPGTEDADSVQIIIPQNQVNRRNDIYIAKVSSTHNVCAKDVYVAIVSTIVETDNPEQEIVPGLQLLGPIYDKFVSVSTLYTPTTSGQDDQIFVTRSYDATSHFETVVEDVHNVWKQMIGKELVLKKREVEVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J4T2</accession>
    <name>A0A2H3J4T2_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">MFS general substrate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WOLCODRAFT_165820</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB467832">
        <property type="protein sequence ID" value="PCH34793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J4T2"/>
    <dbReference type="STRING" id="742152.A0A2H3J4T2"/>
    <dbReference type="OMA" id="WINLRTV"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010573">
        <property type="entry name" value="MFS_Str1/Tri12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF39">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05010)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06609">
        <property type="entry name" value="TRI12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="95"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="298"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="323"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="323"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PCH34793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="360" mass="38364" checksum="D8E5E69A425E942D" modified="2018-01-31" version="1">MFRVDWIGAFLFMAGGIAVMLALNWGSTYGWNSARVIVCFVTGGFAYIIFLGFEHILERRSSLSSSVSTGNPSFWTQPMLSISIFRSLDISITQYATLVSGMVLIVMFYFVAVFMVIVAGRSASNAGVQLIYFAPGMGAGSLLQIRLIKQYRQPKYPIMLGSLVLTISLGLISMAVEKNNTGMIAGFMVMSGVGVGLSIGALAIHARFSQPAGKVAIVSALLLFSRSLGGTIGLAQCGAVLDAKVRQYVTSAVESGAIPDSAAIASSLASLGSLQNINSLPPAVQTIVRDAYRDGTRWAFISLIPWAALGFLGTLCLSNIKDSDAAPSDKEEIPVEVLEDTNISELPHHTQRSSETLRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J4T9</accession>
    <name>A0A2H3J4T9_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CoA-dependent acyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_28852</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467898">
        <property type="protein sequence ID" value="PCH36961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="742152.A0A2H3J4T9"/>
    <dbReference type="OMA" id="MEARDAY"/>
    <dbReference type="OrthoDB" id="2768710at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42034">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42034:SF1">
        <property type="entry name" value="CONDENSATION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH36961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="519" mass="57616" checksum="931B41F8CC366401" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J4X8</accession>
    <name>A0A2H3J4X8_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Electron transfer flavoprotein-ubiquinone oxidoreductase</fullName>
            <shortName evidence="12">ETF-QO</shortName>
            <ecNumber evidence="12">1.5.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">WOLCODRAFT_140560</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 12">Accepts electrons from ETF and reduces ubiquinone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a ubiquinone + reduced [electron-transfer flavoprotein] = a ubiquinol + oxidized [electron-transfer flavoprotein] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24052"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="EC" id="1.5.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="12">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <dbReference type="EC" id="1.5.5.1" evidence="12"/>
    <dbReference type="EMBL" id="KB467887">
        <property type="protein sequence ID" value="PCH36725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J4X8"/>
    <dbReference type="STRING" id="742152.A0A2H3J4X8"/>
    <dbReference type="OMA" id="INFQNCV"/>
    <dbReference type="OrthoDB" id="437331at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004174">
        <property type="term" value="F:electron-transferring-flavoprotein dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040156">
        <property type="entry name" value="ETF-QO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049398">
        <property type="entry name" value="ETF-QO/FixC_UQ-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007859">
        <property type="entry name" value="ETF-QO/FixX_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10617">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN-UBIQUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10617:SF107">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN-UBIQUINONE OXIDOREDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21162">
        <property type="entry name" value="ETFQO_UQ-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05187">
        <property type="entry name" value="Fer4_ETF_QO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 12" id="KW-0274">FAD</keyword>
    <keyword evidence="4 12" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9 12" id="KW-0408">Iron</keyword>
    <keyword evidence="10 12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <keyword evidence="11 12" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="13">
        <location>
            <begin position="598"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU366068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PCH36725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="638" mass="70097" checksum="AD41DCB0C0EC2B33" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J5A9</accession>
    <name>A0A2H3J5A9_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_140607</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467898">
        <property type="protein sequence ID" value="PCH36855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J5A9"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH36855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="94" mass="10268" checksum="AF1D4419CAA48F9D" modified="2018-01-31" version="1">MRPGEEQLADNRLLIPAANIGRRLISYPSIAASKGGTLTERGQSRIAQYVNDGLTCRCAFYATSSSAACPLHSLERHDCRMGCSRTVPHPRVHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J5C3</accession>
    <name>A0A2H3J5C3_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DUF125-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WOLCODRAFT_167495</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CCC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467931">
        <property type="protein sequence ID" value="PCH37442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J5C3"/>
    <dbReference type="STRING" id="742152.A0A2H3J5C3"/>
    <dbReference type="OMA" id="MNFHHTL"/>
    <dbReference type="OrthoDB" id="73465at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008217">
        <property type="entry name" value="Ccc1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31851">
        <property type="entry name" value="FE(2+)/MN(2+) TRANSPORTER PCL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01988">
        <property type="entry name" value="VIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="239"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="300"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PCH37442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="330" mass="34292" checksum="AC18362B83755EE2" modified="2018-01-31" version="1">MSSQPYAPAVPLPSRQNGDTGSKPPVWSINHTTGDEVPPAAKCDRHDTGREGVCCKELIGDDERTLVDPDVVRDVVIGLSDGLTVPFALTAGLSSLGESKLVILGGVAELIAGALSMGIGGFLASQAERDHYRFLRKQTRARVLRSCEGEMEREVFAVLGPVGVDEKTSRGVAQCLMNVEVGSAGEGPSGIASGSDTASRTSVSVADSESGLRWSKDVGLSAFLLKFGEGMEEVPTRRLYISALTIGMGYFFGGLIPLLPYFFEPVAHIALIYSCIVTGIILLVFGAVKARVTGAAGQGVGGYVWGAVSTLLVGGAAAAAAYGLVAVLET</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J5L6</accession>
    <name>A0A2H3J5L6_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Alcohol dehydrogenase GroES domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WOLCODRAFT_158213</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD-104</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467931">
        <property type="protein sequence ID" value="PCH37496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J5L6"/>
    <dbReference type="STRING" id="742152.A0A2H3J5L6"/>
    <dbReference type="OMA" id="PVVFECV"/>
    <dbReference type="OrthoDB" id="3941538at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000721">
        <property type="term" value="F:(R,R)-butanediol dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034079">
        <property type="term" value="P:butanediol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08233">
        <property type="entry name" value="butanediol_DH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF23">
        <property type="entry name" value="(R,R)-BUTANEDIOL DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="8">
        <location>
            <begin position="54"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="7">
        <location>
            <begin position="208"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PCH37496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="384" mass="41258" checksum="C3C6F4A5A7173675" modified="2018-01-31" version="1">MRAVRYYGPGDIRVDNIPEPSITDGKIKIKVWRCVHAINSKYEVAYPNRYAIARTVCGSDVHAYFIRPEASPTATTPHPITGETLPTVMGHEFSGTIVALGRGVDNKKYAVGQNVTIEPVISCMKPTCPQCTSGARNVCPNVSYVGAGGFGGGFSEYVSLSPEYVHVLPAGVSLEAGAMIEPLSVGWHAVKRSSFKPGDRALVIGCGPIGLFVLKSLQALGASWVGVSEPATERREMARKASASTVFDPLSEDVVSETVRVTDGGADVVFDCAGLQASLDTALQAVRPRGTVVGVAVWEKMPTLNTHAIQRKEIMLTSCNGSNDEHPELLQAVAAGKIKGLDELVTRKIALEDFVEMGIKALINEKNKHIKILVHPQKRLETKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J636</accession>
    <name>A0A2H3J636_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidase C14 caspase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WOLCODRAFT_155908</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C14B family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467843">
        <property type="protein sequence ID" value="PCH35233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J636"/>
    <dbReference type="OrthoDB" id="3223806at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050452">
        <property type="entry name" value="Metacaspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104:SF30">
        <property type="entry name" value="METACASPASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104">
        <property type="entry name" value="METACASPASE-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Peptidase C14 caspase" evidence="5">
        <location>
            <begin position="70"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PCH35233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="383" mass="43150" checksum="914497D4BEB9E61D" modified="2018-01-31" version="1">MPSATQTSADDRTSDVAQALISHNRTPSDLSATTTPSRTPSPRPDGQSRKRALSIAVRYDRLQREHPEEDWIRLGGTYADVDILRSLLKKGYGYQDSDITVMKDDDPNFPPTCENILSEMRKLVKGAQSGDHYVFHFSGHGSQLPSEDHDAIWPADVICSSEVTSNYIRSDVSFVDYGARIALNIFQVIHNTLLKDFPSDAHLMIIFDCCHSASVADLPLDIEERMRQDIRSDAAPVLEGEVIPTKLQKHIRLRGTSFKPNVTDDDNDQQFHEVKKDEKYTLPHDHHGVLSLSACGDDELTPDTSNGGLFMKVLKRVLEDHNYHIPIEDLLLEVTDEMVRIIEDHNEKVKKRGDPGQYQCAPSIPHMGCEDEPVKVVHENFEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J775</accession>
    <name>A0A2H3J775_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_147594</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH33498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J775"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013904201" evidence="2">
        <location>
            <begin position="24"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="133"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH33498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="189" mass="18578" checksum="2E26D19DE906F791" modified="2018-01-31" version="1" fragment="single">MFFSLTCAKLLLLAVLLVARASALFIPPWAAGAPALTKSSVGPSSLATGASQDADGNSLGQVEVAFAHTPGGGVGRALPGIPRIDNDNDAVPETLSVSSSLIETVTITVTAASQGSVTGLPSASAITTASPLSSSALTSSDSTRFPGSTTITPSSLPTAQTSVSGFPSLTVLPFESTTTSAAASTTAPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J7S3</accession>
    <name>A0A2H3J7S3_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_159461</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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        </citation>
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        <source>
            <strain evidence="2 3">MD-104</strain>
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    </reference>
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    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="163" mass="17576" checksum="7724A62CB204356D" modified="2018-01-31" version="1">MTGSLLEYIQRVKALRNEDVTLTTSDTLLPTTPSNAEIAALHSLHVDHTPVIELDASPSSSSCRIFTLLIAGEDQQQRRKSGWLEKSRSTWAPVLGGEEEQPPAVRRDVRLYGEEAQAEGRAQEKQRMAANSRKASKTAAGTVAYDDGSAGLGIRDAGIKTGS</sequence>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
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                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
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                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
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            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="OMA" id="DESMEWT"/>
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    </dbReference>
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    </dbReference>
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        </location>
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            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="155" mass="16809" checksum="A7508029B0F57B74" modified="2018-01-31" version="1">MLNLTNLRNLLSQVLSFPSIHTVALFTPQGHLVSFAGDPHKPKDHVRVVVGLSSEAWQETKDQGIGMIESELGRLLVLPVGQSRPAGESGGDVPDPVMLLALNAEKSVSWKELETKARELGRHLENPVSALRGRLAAAPSPINPRPERATRNMTS</sequence>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Barry K."/>
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                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
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                <person name="Benoit I."/>
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                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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    </dbReference>
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        </location>
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            <end position="221"/>
        </location>
    </feature>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH38802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="246" mass="27240" checksum="6F8D90769BC4E1D6" modified="2018-01-31" version="1">MQQTFLNLLSKHKLQMLDYAWRHILWQGFKVCVVRNYVEEVLELKKQMAALILHKLNKTAKTKVAHMIYTNFDSAITAKYRIIVEGWPLTDFCCPSDVGSCNELLVLSHMFKTSTTRFCLLSSEEFKRWKEECLPVAMLVMPSTDPTQSQSNNPAPSTAPVHVDTPPLTSTVIFSLPQPPTPVSSIPSTTQCPSLLEPPEPTSSPLLSMPSALPPSPPPTLLPAHYVTQHSSPVLSLGSKDCAGNK</sequence>
</entry>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Barry K."/>
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                <person name="Henrissat B."/>
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                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
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                <person name="Benoit I."/>
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                <person name="Ferreira P."/>
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                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
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                <person name="Heitman J."/>
                <person name="Hesse C."/>
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                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
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                <person name="Lindquist E."/>
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                <person name="Lundell T."/>
                <person name="Martin R."/>
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                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
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                <person name="Sabat G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C14 caspase" evidence="1">
        <location>
            <begin position="18"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH38882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="121" mass="13348" checksum="688AB3549FE5075D" modified="2018-01-31" version="1">MQVNDCGTTLPPKSSRIFALLVGIDKYRNTDIPALSGCVNDCKNFAAFLLENLGVPEGNIRSLHNEAATRDAILGAIDSHLLLPKVGRRRVARSRLSGLMTKECRRMGPRFMGFPTARSQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J9R8</accession>
    <name>A0A2H3J9R8_WOLCO</name>
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            <fullName evidence="3">L-serine ammonia-lyase</fullName>
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        <lineage>
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            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
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    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
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                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="16 17">MD-104</strain>
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            <name>heme</name>
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        <text evidence="3">Secondary metabolite biosynthesis.</text>
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    <comment type="subcellular location">
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            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH38765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JAZ1"/>
    <dbReference type="STRING" id="742152.A0A2H3JAZ1"/>
    <dbReference type="OMA" id="DNDAGMR"/>
    <dbReference type="OrthoDB" id="1103324at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF2">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ALNH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PCH38765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="524" mass="59593" checksum="B35ED338D0D73DBE" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JB82</accession>
    <name>A0A2H3JB82_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_141275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467998">
        <property type="protein sequence ID" value="PCH39446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JB82"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH39446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="137" mass="14547" checksum="F2745377B3031575" modified="2018-01-31" version="1">MTANPADINMPAELAPPVGALPPLLFDMHAEIHAWPSTSEVTLEASDDLAMFQGDGNAVVMPTSMHENAGPVPGTNASGANVGDTNSKTRGGTFERQPEKRILVIPSPPPHMRPRRVLKPKVDVSAEARGQSFYIPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JBP3</accession>
    <name>A0A2H3JBP3_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein ROT1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Protein rot1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WOLCODRAFT_168065</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ROT1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468031">
        <property type="protein sequence ID" value="PCH39670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JBP3"/>
    <dbReference type="STRING" id="742152.A0A2H3JBP3"/>
    <dbReference type="OMA" id="VASYNQV"/>
    <dbReference type="OrthoDB" id="5327821at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006458">
        <property type="term" value="P:'de novo' protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019623">
        <property type="entry name" value="Rot1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28090">
        <property type="entry name" value="PROTEIN ROT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28090:SF1">
        <property type="entry name" value="PROTEIN ROT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10681">
        <property type="entry name" value="Rot1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013648741" description="Protein ROT1" evidence="10">
        <location>
            <begin position="18"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PCH39670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="221" mass="24178" checksum="A70A49A7B79CF15D" modified="2018-01-31" version="1">MFRCFLVSLTSALVATAQQAIVYMPIHNAMVIYGTWSSGSGGVKTGPVLQILPIGRLPTQIPLGYRIHDGYYEIARYRYTSNGTAPKCITGVMNWVHGTYVLESNGSIVLMPFGDGFQQIQDACAAISNFIEDYNDTELISSWGIFLDSMLGYQLQLYQYNGELLAQQNLILTTPSMLPTHNLRNTTTATSDAIVDLANTNAVLKSAHGIRTSAGDCARRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JBW2</accession>
    <name>A0A2H3JBW2_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WOLCODRAFT_15146</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH34164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JBW2"/>
    <dbReference type="OMA" id="EHSAITP"/>
    <dbReference type="OrthoDB" id="3037101at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013722855" description="Mid2 domain-containing protein" evidence="3">
        <location>
            <begin position="29"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="190"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PCH34164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="334" mass="35584" checksum="1C4AA99E4C5F4AAD" modified="2018-01-31" version="1">MLRHLWQRSMPQLLLLLPALVLIKGTQASFSISPSGNIIQQCSQIDLMWTEQPPIHLWAAPNRDIAAGDPILHDFGVINSSFLYWTVDLCVGQNVSFTYVQESNRYVVLSSGLRSSATLINATSTSIQSSTTSLSMVQTATASIQNSTTSLSMVQTATASIQSSTSSLSMVTTTAKSQDAQVSGRSSSHAAIYGGIAGAIGLLLLVGVAALFLLRRRAYTGKSIVSFMHRDRDNSISSVSHDPASLVTPYNLQADVQSANGALATSESDRPRQEGGFVYRRLEGGPSAASRSSGLQSVSPGIPRESDAGINFTREGVPTTLPPAYQDFTTAKSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JC06</accession>
    <name>A0A2H3JC06_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Proline-specific peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WOLCODRAFT_110564</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467954">
        <property type="protein sequence ID" value="PCH39115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JC06"/>
    <dbReference type="STRING" id="742152.A0A2H3JC06"/>
    <dbReference type="OMA" id="NIPNATW"/>
    <dbReference type="OrthoDB" id="190201at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050228">
        <property type="entry name" value="Carboxylesterase_BioH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002410">
        <property type="entry name" value="Peptidase_S33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005945">
        <property type="entry name" value="Pro_imino_pep"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01250">
        <property type="entry name" value="pro_imino_pep_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43194">
        <property type="entry name" value="HYDROLASE ALPHA/BETA FOLD FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43194:SF2">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN LPX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005539">
        <property type="entry name" value="Pept_S33_TRI_F1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00793">
        <property type="entry name" value="PROAMNOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013789806" evidence="3">
        <location>
            <begin position="24"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="4">
        <location>
            <begin position="63"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PCH39115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="319" mass="35414" checksum="E0F615C0098C4A91" modified="2018-01-31" version="1">MTHLTRSCNWILALFSSLTCLNGVTDVEKVAVSEGTVPFAYGGETYQTYYKVYGDLANGAHTPLVVIHGGPGVSHDYMLPISDLATRASVPVIFYDQIGGARSTHLRSKPANFWTIDLFVGELDNLLSYLSIRESFDLIGHSWGGVIGAEYEVRRQPAGLQHLILSDSLASEELWGRSTAQLLEAFPTEVQEGIAAGMSEPKRFEAAMRKFNEVHGCTVKPTPKELVYSLDQIFGESGDTTVASANILSDWSIVERLHFVTVPTLIINGGSDVAQDFVVAPFYERIPDVKWITFQNSSHMPFWEERERYIDVLLTFLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JCC4</accession>
    <name>A0A2H3JCC4_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_135213</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH33607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JCC4"/>
    <dbReference type="STRING" id="742152.A0A2H3JCC4"/>
    <dbReference type="OMA" id="NFHAARA"/>
    <dbReference type="OrthoDB" id="2687876at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="421"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="482"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="674"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="755"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="817"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="522"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="685"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="713"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="770"/>
            <end position="781"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH33607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="964" mass="108856" checksum="A9E7B1CA31AF40A4" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JCC9</accession>
    <name>A0A2H3JCC9_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Voltage-dependent ion-selective channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WOLCODRAFT_23699</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic mitochondrial porin family.</text>
    </comment>
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        <property type="protein sequence ID" value="PCH39900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="742152.A0A2H3JCC9"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046930">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:porin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:voltage-gated monoatomic anion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Voltage-dependent anion-selective channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="entry name" value="Porin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001925">
        <property type="entry name" value="Porin_Euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027246">
        <property type="entry name" value="Porin_Euk/Tom40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11743:SF70">
        <property type="entry name" value="GH26960P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11743">
        <property type="entry name" value="VOLTAGE-DEPENDENT ANION-SELECTIVE CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Porin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EUKARYTPORIN"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="8" id="KW-0626">Porin</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PCH39900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="294" mass="31263" checksum="02E0881160080040" modified="2018-01-31" version="1">MSLPQPVPPSWKDLGKSSNDLLGRDFPISGTTLEVKTNTPSNVTFKVAGTRDTKSALINADLEGKYVDRKHGLVFTQTWTTANVLRTQVELENQIAKGLKIDLNTALTPDSGSKSALFTTTYKQPGLHSRAFLDLFKGPTFTADTVIGRDGFLAGAEASYNVTEGKVTRYATAVGFSAPEYAVTLHGLGNLSTFAASYYHRVSPDVEAGAKAVYDTKATTQGVSLEVGAKAYLDSAAFVKAKINNSGILALGYTQALRPGVRASFGLALDTQRLNEVAPSGPAHKFGASFTFEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JCZ3</accession>
    <name>A0A2H3JCZ3_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Anaphase-promoting complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WOLCODRAFT_116687</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the cullin family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468053">
        <property type="protein sequence ID" value="PCH40122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JCZ3"/>
    <dbReference type="STRING" id="742152.A0A2H3JCZ3"/>
    <dbReference type="OMA" id="AAKWQES"/>
    <dbReference type="OrthoDB" id="5581181at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007091">
        <property type="term" value="P:metaphase/anaphase transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044554">
        <property type="entry name" value="ANAPC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014786">
        <property type="entry name" value="ANAPC2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057975">
        <property type="entry name" value="TPR_ANAPC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45957">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45957:SF1">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08672">
        <property type="entry name" value="ANAPC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25773">
        <property type="entry name" value="TPR_ANAPC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01013">
        <property type="entry name" value="APC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH40122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="760" mass="87110" checksum="3FEB29AA9466D69E" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JCZ7</accession>
    <name>A0A2H3JCZ7_WOLCO</name>
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        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
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    <gene>
        <name evidence="8" type="ORF">WOLCODRAFT_135344</name>
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    <organism evidence="8 9">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Phaeolaceae</taxon>
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    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD-104</strain>
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        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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    </feature>
    <evidence type="ECO:0000256" key="1">
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="PCH33827.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JD25</accession>
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            <fullName evidence="12">Beta-trefoil</fullName>
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    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
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                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
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                <person name="Stenlid J."/>
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                <person name="Wiebenga A."/>
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                <person name="Eastwood D.C."/>
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            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
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            <strain evidence="10 11">MD-104</strain>
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        <property type="project" value="UniProtKB-SubCell"/>
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        </location>
    </feature>
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        <location>
            <begin position="186"/>
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        </location>
    </feature>
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            <begin position="209"/>
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        </location>
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        <source>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
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                <person name="Ling A."/>
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    </dbReference>
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    </dbReference>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Benoit I."/>
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        <location>
            <begin position="730"/>
            <end position="742"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH37199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="795" mass="87114" checksum="9607EEE30AFD5DCD" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JEQ0</accession>
    <name>A0A2H3JEQ0_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Probable methionine--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="2">6.1.1.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WOLCODRAFT_150754</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>tRNA(Met) + L-methionine + ATP = L-methionyl-tRNA(Met) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13481"/>
            <dbReference type="Rhea" id="RHEA-COMP:9667"/>
            <dbReference type="Rhea" id="RHEA-COMP:9698"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.10"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.10" evidence="2"/>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH40722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JEQ0"/>
    <dbReference type="STRING" id="742152.A0A2H3JEQ0"/>
    <dbReference type="OMA" id="MDTQAFC"/>
    <dbReference type="OrthoDB" id="24670at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006431">
        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00814">
        <property type="entry name" value="MetRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.220.10:FF:000001">
        <property type="entry name" value="methionine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014758">
        <property type="entry name" value="Met-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023457">
        <property type="entry name" value="Met-tRNA_synth_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033911">
        <property type="entry name" value="MetRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00398">
        <property type="entry name" value="metG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43326:SF1">
        <property type="entry name" value="METHIONINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43326">
        <property type="entry name" value="METHIONYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01041">
        <property type="entry name" value="TRNASYNTHMET"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0436">Ligase</keyword>
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    <keyword evidence="6 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methionyl/Leucyl tRNA synthetase" evidence="11">
        <location>
            <begin position="4"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00068817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PCH40722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="516" mass="58081" checksum="7F22EFAFB63AE6F3" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JET0</accession>
    <name>A0A2H3JET0_WOLCO</name>
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        <recommendedName>
            <fullName evidence="7">ABC transporter ATPase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WOLCODRAFT_148538</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467831">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JET0"/>
    <dbReference type="STRING" id="742152.A0A2H3JET0"/>
    <dbReference type="OMA" id="IRDRRMQ"/>
    <dbReference type="OrthoDB" id="189459at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <dbReference type="InterPro" id="IPR019195">
        <property type="entry name" value="ABC_ATPase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046833">
        <property type="entry name" value="ABC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049069">
        <property type="entry name" value="MRB1590-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38149">
        <property type="entry name" value="ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38149:SF1">
        <property type="entry name" value="ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09818">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20446">
        <property type="entry name" value="ABC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21117">
        <property type="entry name" value="MRB1590_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="46"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase of the ABC class C-terminal" evidence="2">
        <location>
            <begin position="220"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="MRB1590-like C-terminal" evidence="4">
        <location>
            <begin position="515"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF21117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PCH34497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="618" mass="66706" checksum="AD6028418DF967C5" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JEW3</accession>
    <name>A0A2H3JEW3_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WOLCODRAFT_27754</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
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                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7 8">MD-104</strain>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
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        <property type="entry name" value="Apc4-like_WD40_dom"/>
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        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
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        <property type="entry name" value="WD40_PAC1"/>
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        <property type="entry name" value="WD40_repeat_CS"/>
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        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19856:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19856">
        <property type="entry name" value="WD-REPEATCONTAINING PROTEIN WDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ANAPC4_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
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        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
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        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
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        </location>
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    <feature type="repeat" description="WD" evidence="4">
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        </location>
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        <location>
            <begin position="450"/>
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        </location>
    </feature>
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            <begin position="13"/>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00038366"/>
        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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        <source>
            <dbReference type="Pfam" id="PF12894"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH35254.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
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                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467854">
        <property type="protein sequence ID" value="PCH35554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="68"/>
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            <end position="52"/>
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    </feature>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH35554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JFZ6</accession>
    <name>A0A2H3JFZ6_WOLCO</name>
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        <submittedName>
            <fullName evidence="4">AB-hydrolase YheT</fullName>
        </submittedName>
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        <name evidence="4" type="ORF">WOLCODRAFT_139984</name>
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    <organism evidence="4 5">
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            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
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                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467854">
        <property type="protein sequence ID" value="PCH35624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JFZ6"/>
    <dbReference type="STRING" id="742152.A0A2H3JFZ6"/>
    <dbReference type="OMA" id="HIEWYSE"/>
    <dbReference type="OrthoDB" id="5954035at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008126">
        <property type="term" value="F:acetylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051792">
        <property type="term" value="P:medium-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051793">
        <property type="term" value="P:medium-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050960">
        <property type="entry name" value="AB_hydrolase_4_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012020">
        <property type="entry name" value="ABHD4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10794">
        <property type="entry name" value="ABHYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10794:SF63">
        <property type="entry name" value="ALPHA_BETA HYDROLASE 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005211">
        <property type="entry name" value="Ab_hydro_YheT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="118"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="2">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="2">
        <location>
            <position position="345"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="2">
        <location>
            <position position="372"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR005211-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PCH35624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="452" mass="49743" checksum="0EC29527F0879812" modified="2018-01-31" version="1" fragment="single">MGALLSLLYSAAHFFPKLYYADKPTTITVKASPHSKEARHESLRTFVESRCPSLLEEFLPAWWLFNGHLQVAYCVLGDFSKIDKVEYDRTLLRTVDGGTIGLDFTPPISERKLRDDAPIVVVLHGLTGGSYESYVRAVLNPACTPVERGGLGYRGVVVNFRGCAGVPLTSPQLYSAGHTDDIRVAVFYLRKRYPKAPLIGVGFSLGANVLTRYLAEEREHSRMIAGCVLGCPWDLVVNSEKIEGSWFHRMVYSSGMGQNLQNIIRQHAHALSQFTSHPVAAALQPTLALEKPPIRLFDQHMTRVIGGSSPPFPLPTALHYYQWASCHTVLHGVRVPFLAINDLDDPIVRAEPPYACGENGYVVTVTTRGGGHLGWFESTGGLGVTRWVTKPTVEWLRAVGEDMVTEWREGKPIREVGGFLKEEGRDDIGCMEIDGGGHIVGTVGEEGFLAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JG14</accession>
    <name>A0A2H3JG14_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Fe-S cluster assembly protein DRE2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WOLCODRAFT_137213</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD-104</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="9">The C-terminal domain binds 2 Fe-S clusters but is otherwise mostly in an intrinsically disordered conformation.</text>
    </comment>
    <comment type="domain">
        <text evidence="9">The N-terminal domain has structural similarity with S-adenosyl-L-methionine-dependent methyltransferases, but does not bind S-adenosyl-L-methionine. It is required for correct assembly of the 2 Fe-S clusters.</text>
    </comment>
    <comment type="domain">
        <text evidence="9">The twin Cx2C motifs are involved in the recognition by the mitochondrial MIA40-ERV1 disulfide relay system. The formation of 2 disulfide bonds in the Cx2C motifs through dithiol/disulfide exchange reactions effectively traps the protein in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the anamorsin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH41142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JG14"/>
    <dbReference type="STRING" id="742152.A0A2H3JG14"/>
    <dbReference type="OMA" id="CEPAVRG"/>
    <dbReference type="OrthoDB" id="311633at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03115">
        <property type="entry name" value="Anamorsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007785">
        <property type="entry name" value="Anamorsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046408">
        <property type="entry name" value="CIAPIN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031838">
        <property type="entry name" value="Dre2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13273">
        <property type="entry name" value="ANAMORSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13273:SF14">
        <property type="entry name" value="ANAMORSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05093">
        <property type="entry name" value="CIAPIN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16803">
        <property type="entry name" value="DRE2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3 9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="7 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe-S cluster assembly protein Dre2 N-terminal" evidence="11">
        <location>
            <begin position="41"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Anamorsin C-terminal" evidence="10">
        <location>
            <begin position="207"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Fe-S binding site B" evidence="9">
        <location>
            <begin position="280"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Cx2C motif 1" evidence="9">
        <location>
            <begin position="280"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Cx2C motif 2" evidence="9">
        <location>
            <begin position="291"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PCH41142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="317" mass="33375" checksum="6DEE83FBFD6716F2" modified="2018-01-31" version="1">MAPTAIYATPVVPQDQQKIVVAVPVKGPALAIGSPATAEDGRYQSLITSLQETRQVDRHMVDRLLDDAVTLTPSSFSSVYVALSAPEYDALAPRLSSLLSQLLSGLEPLGTLHILHLDSALPNLPSELTLAGYKVLSSTATDGIIAQKPAHATSVPLKSAPAAALPLRRKADPERKASKKALWTLNAPSTPTIDAESLLTDADRERPTACEPVFSGAPRKKKACKNCTCGLAELEADELAKSKVVLLDGAESGQTMEVSQGEKDRLVAAAASAPKATSSCGNCYLGDAFRCSSCPYRGLPAFKPGEKVEIDLGMDDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JGE0</accession>
    <name>A0A2H3JGE0_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GTP cyclohydrolase 1</fullName>
            <ecNumber evidence="3">3.5.4.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">GTP cyclohydrolase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WOLCODRAFT_137271</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">GTP cyclohydrolase 1 is the first enzyme in the biosynthetic pathway leading to folic acid.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GTP cyclohydrolase I family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.16" evidence="3"/>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH41252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JGE0"/>
    <dbReference type="STRING" id="742152.A0A2H3JGE0"/>
    <dbReference type="OMA" id="FCEHHFL"/>
    <dbReference type="OrthoDB" id="4966at2759"/>
    <dbReference type="UniPathway" id="UPA00848">
        <property type="reaction ID" value="UER00151"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003934">
        <property type="term" value="F:GTP cyclohydrolase I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006729">
        <property type="term" value="P:tetrahydrobiopterin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00642">
        <property type="entry name" value="GTP_cyclohydro1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.286.10:FF:000003">
        <property type="entry name" value="GTP cyclohydrolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1130.10:FF:000012">
        <property type="entry name" value="GTP cyclohydrolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.286.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00223">
        <property type="entry name" value="FolE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043133">
        <property type="entry name" value="GTP-CH-I_C/QueF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043134">
        <property type="entry name" value="GTP-CH-I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001474">
        <property type="entry name" value="GTP_CycHdrlase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018234">
        <property type="entry name" value="GTP_CycHdrlase_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020602">
        <property type="entry name" value="GTP_CycHdrlase_I_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00063">
        <property type="entry name" value="folE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006825">
        <property type="entry name" value="PRK09347.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006826">
        <property type="entry name" value="PRK09347.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11109:SF7">
        <property type="entry name" value="GTP CYCLOHYDROLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11109">
        <property type="entry name" value="GTP CYCLOHYDROLASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01227">
        <property type="entry name" value="GTP_cyclohydroI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55620">
        <property type="entry name" value="Tetrahydrobiopterin biosynthesis enzymes-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00859">
        <property type="entry name" value="GTP_CYCLOHYDROL_1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00860">
        <property type="entry name" value="GTP_CYCLOHYDROL_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GTP cyclohydrolase I" evidence="12">
        <location>
            <begin position="47"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00055676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PCH41252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="225" mass="24981" checksum="BF50E95F267A0D37" modified="2018-01-31" version="1">MNTPISGVEAGSPLPDPNGLGWPAKSTLSRLNATPAEKAEREQKLAGAVRTILECLGEDPDREGLVRTPERYAQALMWMTRGYEERLADVINDAVFAEDHEEMVIVRDIEISSLCEHHLVPFMGKIAIAYIPNKLVLGISKLARIAETFARRLQVQERLTKQIAIAVQEAIKPRGVAVVMEATHLCMTMRGVQKPGSITVTSCMLGCFRTQQKTREEFLTLIKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JGP3</accession>
    <name>A0A2H3JGP3_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_136953</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH40715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JGP3"/>
    <dbReference type="OMA" id="FLPRMET"/>
    <dbReference type="OrthoDB" id="5598852at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF58">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="65"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH40715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="298" mass="34315" checksum="7E1E8EB522A288BE" modified="2018-01-31" version="1">MRLVMVNRRDNSSAQSAPVSSLKVALPSPVSVEELDTLECLNDGGDKRVSRFVPGILVKFGWHQEAEVHALQFVHGRLSVRTPRVLHHAPFPNTFLEPWDWQKGVWYFFMDECPGVRLDTVIHRMFPAELDHIADQLRILLKEMRSCTSTMPGSVTGGPYDNRFMPHPWQPPHAFPSATEYLAYYREIFLEFCGPEYVDELFGCFPNGPDVLIHLTHGDLLPRNILVDGSTITGVVDWETAGFYPEFWEYCQMHDPGWMIPEWARVLARMFLGPRREREIAAVSRIIRDLHYNNSVFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JH41</accession>
    <name>A0A2H3JH41_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Beta-mannosidase B</fullName>
            <ecNumber evidence="3">3.2.1.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Mannanase B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WOLCODRAFT_24785</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides.</text>
            <dbReference type="EC" id="3.2.1.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; N-glycan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glycosyl hydrolase 2 family. Beta-mannosidase B subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.25" evidence="3"/>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH41492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JH41"/>
    <dbReference type="STRING" id="742152.A0A2H3JH41"/>
    <dbReference type="OMA" id="KRQWKGP"/>
    <dbReference type="OrthoDB" id="2866996at2759"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004567">
        <property type="term" value="F:beta-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:glycoprotein catabolic process"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Beta-mannosidase_GH2"/>
    </dbReference>
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        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
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        <property type="entry name" value="GH"/>
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        <property type="entry name" value="Ig-like_fold"/>
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        <property type="entry name" value="Ig-like_GH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041447">
        <property type="entry name" value="Mannosidase_ig"/>
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        <property type="entry name" value="BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43730:SF1">
        <property type="entry name" value="BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22666">
        <property type="entry name" value="Glyco_hydro_2_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17786">
        <property type="entry name" value="Mannosidase_ig"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="beta-Galactosidase/glucuronidase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="11"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich" evidence="9">
        <location>
            <begin position="194"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Mannosidase Ig/CBM-like" evidence="10">
        <location>
            <begin position="686"/>
            <end position="778"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF22666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PCH41492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="858" mass="98061" checksum="FD42E97F2704B644" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-05-03" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JHD1</accession>
    <name>A0A2H3JHD1_WOLCO</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_109613</name>
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    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467909">
        <property type="protein sequence ID" value="PCH37128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JHD1"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH37128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="72" mass="8164" checksum="5468B01E53D617AF" modified="2018-01-31" version="1">MSTIDEITKPELVPLRWSNQRSQRSNAKPHEGEVIGGRCHVMERLYGLTDERGCMGSWSCGWCDELCIHEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JIR1</accession>
    <name>A0A2H3JIR1_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">F-actin-capping protein subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WOLCODRAFT_136492</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the F-actin-capping protein alpha subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468053">
        <property type="protein sequence ID" value="PCH39763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JIR1"/>
    <dbReference type="STRING" id="742152.A0A2H3JIR1"/>
    <dbReference type="OMA" id="VACIEDH"/>
    <dbReference type="OrthoDB" id="340550at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008290">
        <property type="term" value="C:F-actin capping protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.210:FF:000003">
        <property type="entry name" value="F-actin-capping protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.60">
        <property type="entry name" value="F-actin capping protein, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.210">
        <property type="entry name" value="F-actin capping protein, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002189">
        <property type="entry name" value="CapZ_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037282">
        <property type="entry name" value="CapZ_alpha/beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042276">
        <property type="entry name" value="CapZ_alpha/beta_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042489">
        <property type="entry name" value="CapZ_alpha_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10653">
        <property type="entry name" value="F-ACTIN-CAPPING PROTEIN SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10653:SF0">
        <property type="entry name" value="F-ACTIN-CAPPING PROTEIN SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01267">
        <property type="entry name" value="F-actin_cap_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00191">
        <property type="entry name" value="FACTINCAPA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90096">
        <property type="entry name" value="Subunits of heterodimeric actin filament capping protein Capz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0117">Actin capping</keyword>
    <keyword evidence="4 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PCH39763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="298" mass="33233" checksum="2314896F4DEBBAC5" modified="2018-01-31" version="1">MDPSQQIEAASKFLLQAPPGEINDVLNDVRNIVSDDESLQAGLLPALREYNLAQFTTADVPGHNHQSIISEAARISKPSTEGEETEESDRFWDPRSRTSFRFDHLSLETSEPEPVEPDEESEPFRAALESASLTYLAAHYHDGVTSVFPASGSTSRYYVQIVANKYNPSNYWSGRWRSEYTVDLEERTLKGRILVNVHYYEQGNVQLSTTHSIDLPLPPTITPSSAAASASKVLALVEAEEGKYQTSLNETYTEMSEKTFKGLRRALPMTRSKLDWDKVLGYKLGAELSSNRGMFGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JIZ9</accession>
    <name>A0A2H3JIZ9_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein-S-isoprenylcysteine O-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WOLCODRAFT_66486</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + S-adenosyl-L-methionine = [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:21672"/>
            <dbReference type="Rhea" id="RHEA-COMP:12125"/>
            <dbReference type="Rhea" id="RHEA-COMP:12126"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90510"/>
            <dbReference type="ChEBI" id="CHEBI:90511"/>
            <dbReference type="EC" id="2.1.1.100"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.100" evidence="5"/>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH38749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JIZ9"/>
    <dbReference type="OMA" id="QFGKQWD"/>
    <dbReference type="OrthoDB" id="422086at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004671">
        <property type="term" value="F:protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007269">
        <property type="entry name" value="ICMT_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052527">
        <property type="entry name" value="Metal_cation-efflux_comp"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43847">
        <property type="entry name" value="BLL3993 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43847:SF1">
        <property type="entry name" value="BLL3993 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04140">
        <property type="entry name" value="ICMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PCH38749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="182" mass="20226" checksum="E357C7351ABBEC34" modified="2018-01-31" version="1" fragment="single">VWLIALCDAAVTIAAHYPSEASNTILKFLVAGPPLMAANATLTKTFLAGWVGIIAATAFRVASYRALGRLFTFELSIREDHKLISDGPYTFVRHPSYTALYLLMPPMFACQLGPGSWALECGILKTPMGLVCASVWLGYMSLLCYVMAKRVNVEDEMLKEAFGHQWLEWAARTRYRLIPGIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JJ42</accession>
    <name>A0A2H3JJ42_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_137466</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH41555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JJ42"/>
    <dbReference type="STRING" id="742152.A0A2H3JJ42"/>
    <dbReference type="OMA" id="AYTVMMQ"/>
    <dbReference type="OrthoDB" id="2554293at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051222">
        <property type="entry name" value="PPR/CCM1_RNA-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47942:SF63">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47942">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT (TPR)-LIKE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="528"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH41555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="988" mass="111340" checksum="9F97F4BC5DE10E22" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JJ50</accession>
    <name>A0A2H3JJ50_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Molybdopterin binding oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WOLCODRAFT_137772</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD-104</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KB468124">
        <property type="protein sequence ID" value="PCH42230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JJ50"/>
    <dbReference type="STRING" id="742152.A0A2H3JJ50"/>
    <dbReference type="OMA" id="MSHGYRI"/>
    <dbReference type="OrthoDB" id="10051395at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008482">
        <property type="term" value="F:sulfite oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006790">
        <property type="term" value="P:sulfur compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.420.10">
        <property type="entry name" value="Oxidoreductase, molybdopterin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005066">
        <property type="entry name" value="MoCF_OxRdtse_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008335">
        <property type="entry name" value="Mopterin_OxRdtase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000572">
        <property type="entry name" value="OxRdtase_Mopterin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036374">
        <property type="entry name" value="OxRdtase_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19372:SF7">
        <property type="entry name" value="SULFITE OXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19372">
        <property type="entry name" value="SULFITE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03404">
        <property type="entry name" value="Mo-co_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00174">
        <property type="entry name" value="Oxidored_molyb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00407">
        <property type="entry name" value="EUMOPTERIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56524">
        <property type="entry name" value="Oxidoreductase molybdopterin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidoreductase molybdopterin-binding" evidence="5">
        <location>
            <begin position="120"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="Moybdenum cofactor oxidoreductase dimerisation" evidence="6">
        <location>
            <begin position="335"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PCH42230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="439" mass="48118" checksum="52CD935BCF4E61E2" modified="2018-01-31" version="1">MSTSADILAPATSAMIQTPAPAEPPKPHFPMDFTLEHETIAHSDLLLVCAHEPFNAEPTAAALVEFPVTPNELVYCRNHGPVQEYDYDAFAITVRVRLGKGPNGDADEEQRTQGSEAVVERTFTAKEIREQFEKVEVEAALQCAGNRRKEMSKLQPVVGVLWDDGVVANCVWGGTRLRDVLVAVGVQHPALYDPTSISTYADAPVGPSGLHVHLNSRVTACQDDAYYGASIPLEKALQDEVLLAYEMNSEPLYPDRGGPLRAVVPGFLGARWVKWIDEIEICTDESENYYQRRDYRILPPEIDSRAKAASAWPLYPSMTSLPLNSVVASLTRTSPTSLLAKGYAVGRGACPVTRVQVSVDGERWADARITYSGGAQSGKGESRWSWTLWAAIVSGEEVGEGHHGTVWCRAIDEAGNVQQQRCPWNYRGVGYCPWGAKSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JJA1</accession>
    <name>A0A2H3JJA1_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GSKIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_98042</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468053">
        <property type="protein sequence ID" value="PCH39953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JJA1"/>
    <dbReference type="OrthoDB" id="5804279at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2280.10">
        <property type="entry name" value="Hypothetical protein (hspc210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007967">
        <property type="entry name" value="GSKIP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023231">
        <property type="entry name" value="GSKIP_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05303">
        <property type="entry name" value="GSKIP_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103107">
        <property type="entry name" value="Hypothetical protein c14orf129, hspc210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GSKIP" evidence="2">
        <location>
            <begin position="69"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH39953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="144" mass="15447" checksum="81438EA02F0E5BCB" modified="2018-01-31" version="1">MTWNDSEDASRRLEFDSSHLTGEGHSPGRDIPIDDFPAAELTNALTEQSFGTTSFKIVLTGPLEAAARVVLLEGTALNISLSSQGYKIGRVDAKIGEAGSPTIDETFESLEALLTSVSPRYATARQNALFARLQALSDSRSSDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JJB8</accession>
    <name>A0A2H3JJB8_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WOLCODRAFT_161094</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>melleolide F + FADH2 + chloride + O2 = 6'-chloromelleolide F + FAD + 2 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67160"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:167712"/>
            <dbReference type="ChEBI" id="CHEBI:167713"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:67161"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the flavin-dependent halogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH37848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JJB8"/>
    <dbReference type="STRING" id="742152.A0A2H3JJB8"/>
    <dbReference type="OMA" id="IKFDWLI"/>
    <dbReference type="OrthoDB" id="3340390at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140907">
        <property type="term" value="F:flavin-dependent halogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050816">
        <property type="entry name" value="Flavin-dep_Halogenase_NPB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43747:SF5">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43747">
        <property type="entry name" value="FAD-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="9"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PCH37848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="546" mass="59841" checksum="B099F82C8C704AFD" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JJR2</accession>
    <name>A0A2H3JJR2_WOLCO</name>
    <protein>
        <submittedName>
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                <person name="Sun S."/>
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            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468124">
        <property type="protein sequence ID" value="PCH42520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JK22"/>
    <dbReference type="STRING" id="742152.A0A2H3JK22"/>
    <dbReference type="OMA" id="MMDYEVE"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH42520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="211" mass="23542" checksum="C6818A115F2D1A50" modified="2018-01-31" version="1">MSNSTPGYSSFVRRRIGRAPSPPTWACYEQIPFDDEYTSDSGSESNSCSEDEEDYGRVARHASDISDGDFPATQESERHAPRVGSGTEMEGGDESVSAQKIAELKKDVKGKQRAIEPEHESPRKQHRRKHRQPVVALRPILTIQRSQGFVWNQDLFVPPYIKDRYVASTSPSNASGFVSSSVSSTNSSMMDYEVEVVEIRVKEGELNDIIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH42602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="72" mass="8075" checksum="2ADE7CFE2A420B9B" modified="2018-01-31" version="1">MSHSVSALTDWIPTDHPRWSTVFAFIRQALVLSYVTANSACSLTQRAHWLALLHSSKTWLPCVNSSLISLCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
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    <name>A0A2H3JLY4_WOLCO</name>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB468124">
        <property type="protein sequence ID" value="PCH42515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="742152.A0A2H3JLY4"/>
    <dbReference type="OMA" id="FLGMSDN"/>
    <dbReference type="OrthoDB" id="8119704at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="51"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PCH42515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="288" mass="31902" checksum="7E902C36F0BCBD50" modified="2018-01-31" version="1">MSFLHPARSAAVAVARNIARPSARRFVSSIAPVPLAYDKLVPLNGNATDQPLVILHGLFGMKRNWQSLSKAFLRDLDRPIYCLDLRNHGISPHAEPMTYSAMAVDVLHFLHKHSLANVSLLGHSMGGKVAMAAALSPDLPSGLLRHLIVADIAPSKGPLSPEFNGYVEALRKIEASKVSTRQEAQKLLTPYEKDPMTRAFLLTNLRPQHSHHGPLQFQVPLHIIGDSIPEIGSFPYEPGERIWEGDTLFIKGAKSRYINDRNVPIAKQFFPKSTLETLDTGHWVHAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JM07</accession>
    <name>A0A2H3JM07_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_153293</name>
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    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468135">
        <property type="protein sequence ID" value="PCH43236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JM07"/>
    <dbReference type="STRING" id="742152.A0A2H3JM07"/>
    <dbReference type="OrthoDB" id="2992477at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
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            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Barry K."/>
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                <person name="Sun S."/>
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    </dbReference>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
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                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
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                <person name="Nagy L.G."/>
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                <person name="Stenlid J."/>
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                <person name="Sun S."/>
                <person name="Syed K."/>
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                <person name="Young D."/>
                <person name="Pisabarro A."/>
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            <dbReference type="DOI" id="10.1126/science.1221748"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
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    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RutC family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468053">
        <property type="protein sequence ID" value="PCH40279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JN98"/>
    <dbReference type="STRING" id="742152.A0A2H3JN98"/>
    <dbReference type="OMA" id="NVEMECV"/>
    <dbReference type="OrthoDB" id="309640at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00448">
        <property type="entry name" value="YjgF_YER057c_UK114_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.40:FF:000001">
        <property type="entry name" value="L-PSP family endoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006056">
        <property type="entry name" value="RidA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00004">
        <property type="entry name" value="Rid family detoxifying hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="2-IMINOBUTANOATE/2-IMINOPROPANOATE DEAMINASE RIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803:SF42">
        <property type="entry name" value="MMF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH40279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="125" mass="13523" checksum="AEAF4500D659A5B9" modified="2018-01-31" version="1">MKTCVKSEEAVPPLPQFSHATISNGTVYVSGSIGSDKDWNLAGDIKAQTRAGIQNMEKILQAAGSGLDRVLKCTVFLTNLKEDFKPMNEVYSEFFHTNPPARTCIGVAQLPMGAAFEIECIAEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JNL7</accession>
    <name>A0A2H3JNL7_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribonuclease H2 subunit B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Ribonuclease HI subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WOLCODRAFT_132945</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB468146">
        <property type="protein sequence ID" value="PCH43776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JNL7"/>
    <dbReference type="STRING" id="742152.A0A2H3JNL7"/>
    <dbReference type="OMA" id="AQWVLIA"/>
    <dbReference type="OrthoDB" id="29098at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032299">
        <property type="term" value="C:ribonuclease H2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09270">
        <property type="entry name" value="RNase_H2-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040456">
        <property type="entry name" value="RNase_H2_suB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019024">
        <property type="entry name" value="RNase_H2_suB_wHTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041195">
        <property type="entry name" value="Rnh202_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13383">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13383:SF11">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09468">
        <property type="entry name" value="RNase_H2-Ydr279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17745">
        <property type="entry name" value="Ydr279_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rnh202 triple barrel" evidence="8">
        <location>
            <begin position="30"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Ribonuclease H2 subunit B wHTH" evidence="7">
        <location>
            <begin position="100"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="272"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="289"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PCH43776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="334" mass="37373" checksum="EB11854914413130" modified="2018-01-31" version="1">MTRYVTVLPDDVLDSRVSACRAGPSEGNDGRKDLRMLMLPHPRTGISSLFLPYEPPTCEKSSILEVQSVAPANERSWFMSDGHVLSDGQLFVMTPIDPAFLMIPILQRSIPTEERQGAFRPAEQLLEEAAARILPSTENGSADCYISDVLRLLEFSCVRDALRHICEVKEINPDLVVYRFSPTKVQEYLKRKVTRLAKQENCEISRTIIRHLARDGLMEDGKEHLLESARTRAACDLVSQYIPQDAYQTLLTGYDFAALNAYLRAVQEEVAATTPADETQPKTKAKKGKPQDVDSNDNKRKAQSKASTGVERLKKVNVKGMAKISTFFQKPTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JNZ6</accession>
    <name>A0A2H3JNZ6_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7904 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_138664</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468146">
        <property type="protein sequence ID" value="PCH43910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="742152.A0A2H3JNZ6"/>
    <dbReference type="OMA" id="AFFEIYV"/>
    <dbReference type="OrthoDB" id="6375767at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051014">
        <property type="term" value="P:actin filament severing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008154">
        <property type="term" value="P:actin polymerization or depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057226">
        <property type="entry name" value="DUF7904"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007122">
        <property type="entry name" value="Villin/Gelsolin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11977:SF133">
        <property type="entry name" value="DUF4045 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11977">
        <property type="entry name" value="VILLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25480">
        <property type="entry name" value="DUF7904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7904" evidence="2">
        <location>
            <begin position="945"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="572"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="666"/>
            <end position="686"/>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
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                <person name="Kuo A."/>
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</entry>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
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                <person name="Benoit I."/>
                <person name="Boyd A."/>
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                <person name="Copeland A."/>
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                <person name="Heitman J."/>
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                <person name="Igarashi K."/>
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                <person name="Kallen N."/>
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                <person name="Lindquist E."/>
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                <person name="Lucas S."/>
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                <person name="Morgenstern I."/>
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                <person name="Murat C."/>
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                <person name="Ohm R.A."/>
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        <property type="entry name" value="NDUFAF3/AAMDC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21192:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX ASSEMBLY FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21192">
        <property type="entry name" value="NUCLEAR PROTEIN E3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04430">
        <property type="entry name" value="DUF498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64076">
        <property type="entry name" value="MTH938-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PCH40989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="173" mass="19396" checksum="83608E757E7298FE" modified="2018-01-31" version="1">MFARYLAHTLRRQACNTRPRLIHCSHVRRNSDGGLTNILEGGAAPAVQVKTITSEGIQLMDGLIIPSACIFLDGKVFLWDVPDTQWEGWDRKHFQIFDVVVPKPEILLLGTGRKVSFFPPALRQHLNGLGMQVDVMDTWNACSTYNLLTEEGRTVAAALLPLTPRSWKHLPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JRE3</accession>
    <name>A0A2H3JRE3_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxypeptidase</fullName>
            <ecNumber evidence="6">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WOLCODRAFT_105545</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="6"/>
    <dbReference type="EMBL" id="KB468168">
        <property type="protein sequence ID" value="PCH44722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JRE3"/>
    <dbReference type="STRING" id="742152.A0A2H3JRE3"/>
    <dbReference type="OMA" id="WTFMQIF"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF453">
        <property type="entry name" value="S1, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6 7" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013430278" description="Carboxypeptidase" evidence="6">
        <location>
            <begin position="21"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PCH44722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="486" mass="53001" checksum="51A2F3FE5E1185C5" modified="2018-01-31" version="1">MLLTFATALLGAASVVPVLGGQVPAPDGVWGAAYSYPKVNVESQLKQSATTPGKLRVTENSGVCETTPGVYQASGYGDIASNESIWFWFFEARDNSDTAPFTIWLNGGPGSSSMIGLFQEHGPCRLNNDSSTISYNDYSWNNVSNMLYIDQPVGVGYSYGTLDVGTSEKAAADIWTFLQIFFSDSRFSKYQQHEFALWTESYGGHYGPTFAAYFLQQNAGIANGSVSGQIINLKYLGVGDGLTDPLSQYPGYISYAASNPYYPLVSSSEISAGSEAWNETGGCQDQIKACYDGGSDDTCSAAQDYCNNKILSPLAGNYDVYYILSEDPDPYPPDATSYLNNATLLGLIGAESSWAETNYDVYYNFAQTGDWMRNSRPDLQTVIDSGVRTIIYDGDADYILNFKGVEAMVHNLQTQFSSEFNQKLFTNWTVEGKPAGIYKNAGTFSYVRIFGAGHEVAAYEYGTLARGQAALQMFSQIMSNQSLYST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JRT9</accession>
    <name>A0A2H3JRT9_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">U1 small nuclear ribonucleoprotein C</fullName>
            <shortName evidence="9">U1 snRNP C</shortName>
            <shortName evidence="9">U1-C</shortName>
            <shortName evidence="9">U1C</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WOLCODRAFT_137436</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the U1 snRNP. The U1 snRNP is composed of the U1 snRNA and the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least 3 U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. SNRPC/U1-C interacts with U1 snRNA and the 5' splice-site region of the pre-mRNA. Interacts (via N-terminus) with TIA1 (via C-terminus); thereby promoting spliceosomal U1 snRNP recruitment to 5' splice sites.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">U1 snRNP is composed of the 7 core Sm proteins B/B', D1, D2, D3, E, F and G that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least 3 U1 snRNP-specific proteins U1-70K, U1-A and U1-C. U1-C interacts with U1 snRNA and the 5' splice-site region of the pre-mRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the U1 small nuclear ribonucleoprotein C family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH41509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JRT9"/>
    <dbReference type="STRING" id="742152.A0A2H3JRT9"/>
    <dbReference type="OMA" id="QMRPPLM"/>
    <dbReference type="OrthoDB" id="76567at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000243">
        <property type="term" value="C:commitment complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030627">
        <property type="term" value="F:pre-mRNA 5'-splice site binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030619">
        <property type="term" value="F:U1 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000395">
        <property type="term" value="P:mRNA 5'-splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000059">
        <property type="entry name" value="U1 small nuclear ribonucleoprotein C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03153">
        <property type="entry name" value="U1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000690">
        <property type="entry name" value="Matrin/U1-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013085">
        <property type="entry name" value="U1-CZ_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017340">
        <property type="entry name" value="U1_snRNP-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31148">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31148:SF1">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
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                <person name="Martinez A.T."/>
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                <person name="Spatafora J.W."/>
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                <person name="Benoit I."/>
                <person name="Boyd A."/>
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                <person name="Findley K."/>
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                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="PCH43313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JTM7"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013642041" description="Secreted protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH43313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="88" mass="9423" checksum="A24C00F87BEAE4A0" modified="2018-01-31" version="1">MSPYFGTIFCIICVIFTSWAAVCMSYCRAAALAPAPGPGSSRAPRVLAVGVSVYCTPQPYSSLSPRVPFATCRYTIHVHQMIAPTAVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JUG4</accession>
    <name>A0A2H3JUG4_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">REJ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WOLCODRAFT_17124</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH41468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JUG4"/>
    <dbReference type="STRING" id="742152.A0A2H3JUG4"/>
    <dbReference type="OMA" id="QDEEDMT"/>
    <dbReference type="OrthoDB" id="3258719at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12087">
        <property type="entry name" value="TM_EGFR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013796564" description="REJ domain-containing protein" evidence="3">
        <location>
            <begin position="32"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="249"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PCH41468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="442" mass="44490" checksum="1618286F9CCEC656" modified="2018-01-31" version="1">MRRCSSAAARSLTLFSIAVLIVAQSFMLVSAQSIATDAPAPSLSAPIASSPLSVPIAAPSSSSDAVKATTSADTATPAAASTPSTTSAPAKSPAASSSAAPVATTSSSTAPVAATSTSTSADNKPSSSAVPSSSSQTVLSSSSSSPIVASSTSVIPSSSSQLPLTSSSTSSLISSIATATSTSAAAVVPLATLKESITTTPPSSSSLGTQSIVYSTDMSGVSTVSGVVGAASTSTTDSTSSKGFLSNKAAVAGVFSVLGLFVLGGIVSVIMRVVRHHRKRKHDDEDMTYFDKDMGPNYADSTRGGDAEDNGSAVDVLTHAASDAYPDRSTHYGMMDDTQPRTSIFEYAPGTAIAAARSQAGPYVYSAQQQTGYNNGFTNAQQQTGYNNGFTNAHYQTQDPASAAFAYTDPYAAARPVMAPAHGGGQYGYGNYAGDAYLVNTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JUW5</accession>
    <name>A0A2H3JUW5_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Elongation factor 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Eukaryotic elongation factor 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">WOLCODRAFT_26171</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein biosynthesis; polypeptide chain elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB468146">
        <property type="protein sequence ID" value="PCH43763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JUW5"/>
    <dbReference type="STRING" id="742152.A0A2H3JUW5"/>
    <dbReference type="OMA" id="EDHRKFG"/>
    <dbReference type="OrthoDB" id="2110130at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18626">
        <property type="entry name" value="CD_eEF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000076">
        <property type="entry name" value="Elongation factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.990:FF:000002">
        <property type="entry name" value="mRNA export factor elf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000193">
        <property type="entry name" value="Probable Elongation factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015688">
        <property type="entry name" value="eEF3_ABC2_chromodomain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047038">
        <property type="entry name" value="eEF3_chromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF14">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HEAT_EF3_GNC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24987">
        <property type="entry name" value="HEAT_EF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
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    <keyword evidence="7" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <feature type="repeat" description="HEAT" evidence="14">
        <location>
            <begin position="253"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="17">
        <location>
            <begin position="456"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="17">
        <location>
            <begin position="696"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="16">
        <location>
            <begin position="825"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1007"/>
            <end position="1088"/>
        </location>
    </feature>
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        <location>
            <begin position="1010"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1079"/>
            <end position="1088"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004815"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00011054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00050030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00050045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PCH43763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="1088" mass="118615" checksum="61F83169DD1175CB" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JVC0</accession>
    <name>A0A2H3JVC0_WOLCO</name>
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        <submittedName>
            <fullName evidence="3">ARM repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_164833</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006409">
        <property type="term" value="P:tRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051177">
        <property type="entry name" value="CIK-Related_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984:SF3">
        <property type="entry name" value="N-TERMINAL KINASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="759"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="705"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="765"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="800"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="845"/>
            <end position="872"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH43923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="879" mass="93949" checksum="28240093EB0D6473" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JXG7</accession>
    <name>A0A2H3JXG7_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">20S-pre-rRNA D-site endonuclease NOB1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WOLCODRAFT_99466</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for the synthesis of 40S ribosome subunits. Has a role in processing 20S pre-rRNA into the mature 18S rRNA, where it is required for cleavage at the 3' end of the mature 18S rRNA (D-site). Accompanies the 20S pre-rRNA from the nucleus to the cytoplasm.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
            <location evidence="7">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the NOB1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH40877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JXG7"/>
    <dbReference type="STRING" id="742152.A0A2H3JXG7"/>
    <dbReference type="OMA" id="GYELECE"/>
    <dbReference type="OrthoDB" id="446759at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="20S-pre-rRNA D-site endonuclease NOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.210.10">
        <property type="entry name" value="Nin one binding (NOB1), Zn-ribbon-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NOB1"/>
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    <dbReference type="InterPro" id="IPR017117">
        <property type="entry name" value="Nob1_euk"/>
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    <dbReference type="InterPro" id="IPR036283">
        <property type="entry name" value="NOB1_Zf-like_sf"/>
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    <dbReference type="InterPro" id="IPR014881">
        <property type="entry name" value="NOB1_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033411">
        <property type="entry name" value="Ribonuclease_PIN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12814">
        <property type="entry name" value="RNA-BINDING PROTEIN NOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12814:SF2">
        <property type="entry name" value="RNA-BINDING PROTEIN NOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17146">
        <property type="entry name" value="PIN_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08772">
        <property type="entry name" value="Zn_ribbon_NOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037125">
        <property type="entry name" value="D-site_20S_pre-rRNA_nuclease"/>
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    </dbReference>
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        <property type="entry name" value="NOB1 zinc finger-like"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Ribonuclease PIN" evidence="11">
        <location>
            <begin position="13"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Nin one binding (NOB1) Zn-ribbon-like" evidence="10">
        <location>
            <begin position="334"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="114"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="481"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="187"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="221"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="254"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="344"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="347"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="359"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="362"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR037125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR037125-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PCH40877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="513" mass="55694" checksum="74B71AD460D3F556" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JXS0</accession>
    <name>A0A2H3JXS0_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Clathrin/coatomer adaptor adaptin-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WOLCODRAFT_138003</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
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        <property type="protein sequence ID" value="PCH42648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="742152.A0A2H3JXS0"/>
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    <dbReference type="OrthoDB" id="68581at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030123">
        <property type="term" value="C:AP-3 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026740">
        <property type="entry name" value="AP3_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026739">
        <property type="entry name" value="AP_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11134">
        <property type="entry name" value="ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AP3_complex_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
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        <location>
            <begin position="48"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="671"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="712"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="738"/>
            <end position="788"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PCH42648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="795" mass="88004" checksum="B9E153A412948E67" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JY10</accession>
    <name>A0A2H3JY10_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Exocyst complex component SEC5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WOLCODRAFT_105808</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the exocyst complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the SEC5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468168">
        <property type="protein sequence ID" value="PCH44873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JY10"/>
    <dbReference type="STRING" id="742152.A0A2H3JY10"/>
    <dbReference type="OMA" id="RMWMDVD"/>
    <dbReference type="OrthoDB" id="26242at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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    <keyword evidence="3 4" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
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    <feature type="domain" description="Exocyst complex component EXOC2/Sec5 N-terminal" evidence="6">
        <location>
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            <end position="873"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
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            <end position="904"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU365069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF15469"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH44873.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="904" mass="100013" checksum="8063A0E2972DCEB7" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JYP8</accession>
    <name>A0A2H3JYP8_WOLCO</name>
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        <recommendedName>
            <fullName evidence="7">Calcium-binding protein NCS-1</fullName>
        </recommendedName>
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    <gene>
        <name evidence="9" type="ORF">WOLCODRAFT_100190</name>
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    <organism evidence="9 10">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Agaricomycetes</taxon>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9 10">MD-104</strain>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
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    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
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    </feature>
    <feature type="domain" description="EF-hand" evidence="8">
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    </feature>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
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            <end position="179"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="190" mass="22130" checksum="393E75422D253B01" modified="2018-01-31" version="1">MGKSQSKLSPEQLADLQKHTYFDKRELQQWYKGFLKDCPSGQLDKAEFGRIYKQFFPFGDPGEFAEYVFNVFDENKNGTIDFKEFICALSVTSRGRLDEKLKWAFQLYDIDGNGYITYQEMLQIVQSIYKMTGSMVKLPADEDTPEKRVDKIFRNMDRDKDAQLNYEEFVEGSKQDPTIVQALSLYDGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JZ88</accession>
    <name>A0A2H3JZ88_WOLCO</name>
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        <submittedName>
            <fullName evidence="8">DUF396-domain-containing protein</fullName>
        </submittedName>
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        <name evidence="8" type="ORF">WOLCODRAFT_118978</name>
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        <name type="common">Brown rot fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13144">
        <property type="entry name" value="TEX261 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Erv26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="12"/>
            <end position="31"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="90"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="211"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="232"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="257"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="315"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="326"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PCH41457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="336" mass="37029" checksum="5AB4E178C5B64EFC" modified="2018-01-31" version="1">MTLLHTLSYGGAAAAFTFVTLSLASGLLWLSELIEEHSRLAKAVGQKGIYAIIALHFILYFSDSLPLKHILFSVCCHAVYLQNFTASWPFISLTSLSFIASCILVIADHFLWFFYFARITQDARHRTHRPYGTPAKVQNAPGFADIATFFGVCVWLVPLFLFLSLSANDNALPINTGHSSIPNTPTLPSTPINTRPRSSLFRSLYDSLPQVRARPRRRDTSEGIIAPRSPNIARSTLTPSPIHSPTLLPRVPSMNGLPSPLLSPRRVSSDGFTAEPSLLTPDLTQEEEASDHLTPFRVGTPPRRMSAGGPPSRRSSMETRLEMRRTTSSGTNPLTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JZJ1</accession>
    <name>A0A2H3JZJ1_WOLCO</name>
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        <submittedName>
            <fullName evidence="5">RNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WOLCODRAFT_89385</name>
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    <organism evidence="5 6">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5 6">MD-104</strain>
        </source>
    </reference>
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        <property type="entry name" value="SLIRP/GR-RBP-like"/>
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    </dbReference>
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            <end position="152"/>
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        </location>
    </feature>
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            <end position="236"/>
        </location>
    </feature>
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            <begin position="243"/>
            <end position="252"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH41577.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="276" mass="31838" checksum="1D668146A2AA9382" modified="2018-01-31" version="1">MYGDSAAPPVDPYTDAYNEPPPPASGPAVDPRDRDLPPPRGRSRSRSPVRGSSYRRSPPPRRPPHAPIAPNPSNVLGVFGLSIRTTERDLDDEFSRFGRVEKVVIVYDQRSDRSRGFGFISMSTVDEAARCIKELNGVDLNGRRIRVDYSVTDRPHAPTPGEYMGHRRRRGRDTYPGHRDDRYDDIKDSSFRDSFRDRRDRDPYRRDDRDRDNYGRDSRDWRDRRSPPPRRYSPDYRRRRSYSRSPPRGSSPTRARDYDAPSAAPPPSSAAEPPRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JZW0</accession>
    <name>A0A2H3JZW0_WOLCO</name>
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        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
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        <name evidence="10" type="ORF">WOLCODRAFT_151765</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
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        <lineage>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD-104</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
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    </comment>
    <comment type="pathway">
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    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="project" value="InterPro"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="478"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
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        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PCH41707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="539" mass="59888" checksum="A2EF1A3C13052F2A" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K0U0</accession>
    <name>A0A2H3K0U0_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_33963</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
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                <person name="Nagy L.G."/>
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                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
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                <person name="Samejima M."/>
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                <person name="St John F."/>
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                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
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            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">MD-104</strain>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <sequence length="61" mass="7074" checksum="C2E57A5E3BEEE160" modified="2018-01-31" version="1" fragment="single">PCDQDLYQSRTHIIVQYPLHEHARHILRTVSPTITLPILFNTKRGLNALANFFARSNAFKK</sequence>
</entry>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
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                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
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                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
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                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
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                <person name="Kallen N."/>
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                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
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            <end position="385"/>
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    </evidence>
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        <source>
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    <sequence length="457" mass="49299" checksum="071DB1A61EF0A7B9" modified="2018-01-31" version="1">MTARLARSLVNPSPLRSPLALRMEPPSVGATGEANRPPPTQLVRLTEAPSPTATGSNGAKAAGVPTVWNLAPANARRLPALLRLSSVLALSTADRPRRFAETLARRTRPHILRPTFSVLAAFAGCTFRQERGLEPDCAHAPMTHVCSYRARALSPARARTRSTFRLGPRADRRRCAVWAVSTYAHSISPFVAVMITSTSPIPTDDFAVLFTARPRSAAPCARPLHQLSVLRSSTRICDDIARRTKFNNTGTCPATNETSGDAVRAAAPDHMECPHSSIAAANNTEHCNLRGRISPKDIRLFLIESVVASFCHTQALHRFYCHLGLKHSHETRTRPHIDTSEWDADLPPPPLAGCATRAHARSPTFPSAAGPGRARSSESACPSADVPRGHTVLGYPTHARAFRKRRALCTAQFTIRAVAFSRRAHGADASADLSLALPRASCQSQAPRAWALGQVAV</sequence>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
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                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
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                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD-104</strain>
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        </subcellularLocation>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF02229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PCH43594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="155" mass="17574" checksum="388D2289EE59B6F3" modified="2018-01-31" version="1">MVKRKSAAAPRDEEDAQEYASDSIPEPPVKRKTAKTPTVRPRYDQEEEEEEDQPPRKRASKSTAKPTSSKLEESEDQGVYVKANDEGEKYIDLGKKRRATVRSFKGTVFLDIREYYGAEGDEKPGKKGISLSLEQWQSLKNASDAIDTLFKKMTK</sequence>
</entry>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
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                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
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                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
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                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
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                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="PCH44914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="742152.A0A2H3K774"/>
    <dbReference type="OMA" id="WIANERF"/>
    <dbReference type="OrthoDB" id="2020070at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055100">
        <property type="entry name" value="GNAT_LYC1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053013">
        <property type="entry name" value="LAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34815">
        <property type="entry name" value="LYSINE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34815:SF2">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GNAT_LYC1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LYC1 C-terminal" evidence="1">
        <location>
            <begin position="199"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH44914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="391" mass="43749" checksum="069110E4D44A6E39" modified="2018-01-31" version="1">MSSFSLADLSLFLATPEQTYESRKWTAVQWAKGLSLAHYIQRDVIMESLEHATDNKLTTWVLAPRNDPTTLDFMCSCETFRREALIARSSAVTEASAYGIASVFTPEEKRRRGYAQHMMRLLHWILAPRSSMPDKFPAAWGGPPKAFVHTGDARFSVIYSDVGSEFYRACGPSPSLREGWLERGSIQTALDTSTAPATYAEDQVAEKSWHLLSENDVNAVFSREASWVRADLAHAATSTPRTLFSFLPDDGVGASLIKRTMNFTSEGQPTWGAAVAEAINGAQPDEVTYATWTLDILSDSRSLVVTRLRTTTDTFKGLLDQLIKFARQQNISAIDIWGLPENLQHLAGEFGWTTSHRSEHLSAFKWYGSENAGEVDWLFNEKYVVQFRKSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IU64</accession>
    <name>A0A2H3IU64_WOLCO</name>
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        <recommendedName>
            <fullName evidence="3">Cupredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_160132</name>
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    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH33520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="742152.A0A2H3IU64"/>
    <dbReference type="OMA" id="NTAASHC"/>
    <dbReference type="OrthoDB" id="1921208at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Cupredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
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        <property type="entry name" value="Ser-rich/MCO-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883:SF4">
        <property type="entry name" value="CUPREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883">
        <property type="entry name" value="SERINE-RICH PROTEIN, PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="2"/>
    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH33520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="324" mass="33503" checksum="68369A852D6CBE1B" modified="2018-01-31" version="1">MPVSANQTDNFPTFTVTVNDTNPVWVYCRQADNTPASHCGQGMVFAVNPGANGTETSFAKFLNNALAEGAAFKAAASSASSIAASTASVAYTTAAYGGVTIPAEPSPIVVTETITVQASSWTTTYSSYIGSPEPTPVSLNGTIHRVVVGGSDGQLTYTPSNITAEPRDVVVFEFHQKNHTATQSSFDDPCHILTNATTNEVIGLDSGFMPVADDATEFPTFNVTVNDTAPLWFYCKQHTPTGASHCGEGMVFAVNAVADSARNFSAFQALAKELNGTGTSTSSAGSSASTGTHSSTGTASATFPTINAIWALVPTLIAVLAGFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IUA5</accession>
    <name>A0A2H3IUA5_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Chromatin remodeling complex protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WOLCODRAFT_160171</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
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                <person name="Stenlid J."/>
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                <person name="Sun S."/>
                <person name="Syed K."/>
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                <person name="Wiebenga A."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="332390at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="DDT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028942">
        <property type="entry name" value="WHIM1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028941">
        <property type="entry name" value="WHIM2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013136">
        <property type="entry name" value="WSTF_Acf1_Cbp146"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32075">
        <property type="entry name" value="ISWI CHROMATIN-REMODELING COMPLEX SUBUNIT YPL216W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32075:SF6">
        <property type="entry name" value="ISWI CHROMATIN-REMODELING COMPLEX SUBUNIT YPL216W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02791">
        <property type="entry name" value="DDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10537">
        <property type="entry name" value="WAC_Acf1_DNA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WHIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15613">
        <property type="entry name" value="WSD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51136">
        <property type="entry name" value="WAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WAC" evidence="7">
        <location>
            <begin position="28"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="DDT" evidence="6">
        <location>
            <begin position="428"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="149"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="310"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="357"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="675"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="149"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="357"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="708"/>
            <end position="727"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PCH33566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
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                <person name="Benoit I."/>
                <person name="Boyd A."/>
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                <person name="Copeland A."/>
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                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
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                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
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                <person name="Kallen N."/>
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            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
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                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
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                <person name="Kuees U."/>
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                <person name="Kuo A."/>
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                <person name="Lindquist E."/>
                <person name="Ling A."/>
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                <person name="Sun S."/>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
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                <person name="Martinez A.T."/>
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                <person name="Spatafora J.W."/>
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                <person name="Benoit I."/>
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                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
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                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
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            <dbReference type="DOI" id="10.1126/science.1221748"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Sabat G."/>
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                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS17 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH32959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J2J0"/>
    <dbReference type="STRING" id="742152.A0A2H3J2J0"/>
    <dbReference type="OMA" id="RWMTHRV"/>
    <dbReference type="OrthoDB" id="274752at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00364">
        <property type="entry name" value="Ribosomal_uS17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000266">
        <property type="entry name" value="Ribosomal_uS17"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004123">
        <property type="entry name" value="PRK05610.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S11 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US17M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00366">
        <property type="entry name" value="Ribosomal_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00973">
        <property type="entry name" value="RIBOSOMALS17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="80"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="80"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="104"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PCH32959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="117" mass="13020" checksum="01CF3C6E4F867BE6" modified="2018-01-31" version="1">MPPMAFTGVVTKVGFMNKTATVTVSRWIMHPRTGKRIERSKKYLTHDERNELRHGDTVLIRNCPPISARKRFKLEQIIKRPDEERDEAHARMAAAASKINAQGAGATPSVPPTTTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J2N5</accession>
    <name>A0A2H3J2N5_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-CoA dehydrogenase NM domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_108790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467876">
        <property type="protein sequence ID" value="PCH36492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J2N5"/>
    <dbReference type="STRING" id="742152.A0A2H3J2N5"/>
    <dbReference type="OMA" id="EDERWAF"/>
    <dbReference type="OrthoDB" id="538336at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003997">
        <property type="term" value="F:acyl-CoA oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005504">
        <property type="term" value="F:fatty acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033540">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA oxidase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055060">
        <property type="entry name" value="ACOX_C_alpha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012258">
        <property type="entry name" value="Acyl-CoA_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909:SF382">
        <property type="entry name" value="ACYL-COENZYME A OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909">
        <property type="entry name" value="ELECTRON TRANSPORT OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22924">
        <property type="entry name" value="ACOX_C_alpha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA oxidase C-alpha1" evidence="1">
        <location>
            <begin position="211"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH36492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="521" mass="57140" checksum="A4CA3A1E39287AF1" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J2X7</accession>
    <name>A0A2H3J2X7_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WOLCODRAFT_140205</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467865">
        <property type="protein sequence ID" value="PCH36065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J2X7"/>
    <dbReference type="STRING" id="742152.A0A2H3J2X7"/>
    <dbReference type="OMA" id="YVLNDNM"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03752">
        <property type="entry name" value="proteasome_alpha_type_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000031">
        <property type="entry name" value="Proteasome subunit alpha type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
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                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
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                <person name="Rokas A."/>
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                <person name="Sun S."/>
                <person name="Syed K."/>
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                <person name="Wiebenga A."/>
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            <strain evidence="2 3">MD-104</strain>
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        <location>
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        </location>
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    </evidence>
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    </evidence>
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    <sequence length="340" mass="38378" checksum="2E4C44D6E373AEEC" modified="2018-01-31" version="1" fragment="single">MTNFRNRASDLVEIQEIDGLGIGSAILAGKIERALEQNTKHGRSVDLKRPMWRTSSVSLMGFDPVLGTTTTTPYRIKAIQYPWRLEQRNKDNPERLKAWLSELYDKVGVVDVPLDGDDADSSSMAVEDSGTTDVSAERTVVHYVKINAYLEKHSIPRYGLAKMLYGEDLGETSNFHVTISATAKYFKNGPRNERSHMRIVLDIVREPLSKFTSTKQLIRVIRDAIIGHLLAYLSSVLHRDVSFGNVMLVRKGAVEFCGFIDDLDYGSPVDSSKFRWKGIKGTPFQGKSLWGTLLSAGEQKRFRELENELKERTGTVEFMAMELMNADPKQDVSHQVHHDL</sequence>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
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                <person name="Coutinho P.M."/>
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                <person name="Ferreira P."/>
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                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
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                <person name="Lindquist E."/>
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                <person name="Morgenstern I."/>
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                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
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                <person name="Sabat G."/>
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                <person name="Stenlid J."/>
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                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
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                <person name="Martinez A.T."/>
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                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
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                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
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        <source>
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            <strain evidence="2 3">MD-104</strain>
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    <sequence length="1895" mass="206680" checksum="C713BBCA981B3D43" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J6C1</accession>
    <name>A0A2H3J6C1_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">S-adenosylmethionine synthase</fullName>
            <ecNumber evidence="11">2.5.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">WOLCODRAFT_22860</name>
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    <organism evidence="16 17">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the formation of S-adenosylmethionine from methionine and ATP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>L-methionine + ATP + H2O = S-adenosyl-L-methionine + phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21080"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.5.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="11">Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the AdoMet synthase family.</text>
    </comment>
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        <property type="reaction ID" value="UER00080"/>
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        <property type="term" value="F:ATP binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:metal ion binding"/>
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        <property type="term" value="F:methionine adenosyltransferase activity"/>
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        <property type="term" value="P:S-adenosylmethionine biosynthetic process"/>
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        <property type="entry name" value="S-AdoMet_synthetase_sfam"/>
    </dbReference>
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        <property type="entry name" value="metK"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="S-ADENOSYLMETHIONINE SYNTHETASE"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
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    <keyword evidence="3 11" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="9 11" id="KW-0630">Potassium</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S-adenosylmethionine synthetase N-terminal" evidence="13">
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            <begin position="17"/>
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        </location>
    </feature>
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    </evidence>
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    </evidence>
    <sequence length="393" mass="42833" checksum="7810631B59A384A0" modified="2018-01-31" version="1">MPANGTVHAAALAPGHFLFTSESVGEGHPDKICDQVSDAILDACLAEDPFSKVACETAAKTGMIMVFGEITTKARIDFQKVIRNTIKEIGYDDSSKGFDYKTCNILVAIEQQSPDIAQGLDHGALEHIGAGDQGIMFGYATDETPEYMPLTLVLAHRLNQAMAVARRAGVLPWLRPDSKTQVTIEYKKEGGATIPLRVDTIVVSTQHAEEITTEELRKEILEKIIKQVVPAELLDERTVYHIQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDWSKVDRSAAYTARWIAKSLVAGGLARRALVQLSYAIGVAEPLSIYVDTYGTGKKSDEELVDIVRNNFDLRPGVIVQQLGLQKPQYRKTASYGHFGNSEYSWEQPKKLQL</sequence>
</entry>
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    <accession>A0A2H3J6V3</accession>
    <name>A0A2H3J6V3_WOLCO</name>
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        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
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        <name evidence="7" type="ORF">WOLCODRAFT_147480</name>
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    <organism evidence="7 8">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
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            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
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                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH38050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="68" mass="7311" checksum="8715C7C21F47E774" modified="2018-01-31" version="1">MLGQRLQHGHRCPAGSGTFPPAVQTRSPVADPTQTHVLLQPATCEPMSLSTAHASEEVHKRLVSDQTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J7G3</accession>
    <name>A0A2H3J7G3_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">cAMP-dependent protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">WOLCODRAFT_140039</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.11" evidence="1"/>
    <dbReference type="EMBL" id="KB467854">
        <property type="protein sequence ID" value="PCH35713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J7G3"/>
    <dbReference type="STRING" id="742152.A0A2H3J7G3"/>
    <dbReference type="OMA" id="NDPFFDW"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004691">
        <property type="term" value="F:cAMP-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05580">
        <property type="entry name" value="STKc_PKA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000005">
        <property type="entry name" value="cAMP-dependent protein kinase catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000005">
        <property type="entry name" value="cAMP-dependent protein kinase catalytic subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353:SF153">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="92"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="13">
        <location>
            <begin position="350"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="44"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PCH35713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="411" mass="47120" checksum="57B5355829DB9F9A" modified="2018-01-31" version="1">MAMFKRMTDKLGHRGPSRTPMQASPSSSFSSNTMSMLSHEHRGSISTERTSVSNYSKKVEVPETEPEETTVAELPPTLRPLRPKGVYRLSDFIIQRTLGTGSFGRVHLVRSKHNLRFYAIKVMNKEKIVKMKQVSHTRNEQMMLQVVQHPFIINLWGTFQDTANLYMVMDFVPGGELFTLLRRSNRFPDPVAKFYAAEVALALNYLHSLDIIYRDLKPENILLNFDGHIKIADFGFAKYCSTTVWTLCGTPDYLAPEIIGNARYNKSVDWYALGVLTFEMLSGLPPFHEPDITPVRLYEKIATGPACIVWPNFHPNAKDLILKFMERDPSKRYGNLRHGADDVFAHPWFREVDWNKLRNREIQAPYQPRITSDGDASAFERYPEIDANVQYGSVTQDPYGDQFPDFDYTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J857</accession>
    <name>A0A2H3J857_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WOLCODRAFT_19662</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD-104</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467832">
        <property type="protein sequence ID" value="PCH34919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J857"/>
    <dbReference type="STRING" id="742152.A0A2H3J857"/>
    <dbReference type="OMA" id="CANAMGM"/>
    <dbReference type="OrthoDB" id="3268858at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
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        <property type="entry name" value="GMC_OxRtase_C"/>
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    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR11552:SF201">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
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    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
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        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
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    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="7">
        <location>
            <begin position="66"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
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    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PCH34919.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="287" mass="32099" checksum="170C8A594C7CCD9F" modified="2018-01-31" version="1">MPRTNTPVHTLQQDRQNLKVLVSALVYRILTARSSNGKTTARRVEFGYGRDKHIVNASREVILCVGALKSPHILELSGIGNRDVLNRIGVTVDVELPGIGNNVQEHVFTGPSFELRDDVEFETVDILLRDSAVAIKHAELQLKNGTPGCKIISFPGHPSIPNLPVEGKCYVSIMSMMNYTFSRGTIHSISNDPREEPEFDPHYLEEEAGLEIRCEAIKFVRGLSQISPLKNMIDWIKNNFNTTWHTCGSCSMWPQDKDGVVDPELKRLYTISQNKSFCANAMGMQSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J8F1</accession>
    <name>A0A2H3J8F1_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Actin cytoskeleton-regulatory complex protein PAN1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Actin cytoskeleton-regulatory complex protein pan1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">WOLCODRAFT_136325</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">MD-104</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:positive regulation of Rho protein signal transduction"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
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        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="DBL_dom_sf"/>
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        <property type="entry name" value="DH_dom"/>
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        <property type="entry name" value="DUF1720"/>
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        <property type="entry name" value="EF-hand-dom_pair"/>
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        <property type="entry name" value="Endocytic_GEF_Adapter"/>
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        <property type="entry name" value="GDS_CDC24_CS"/>
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        <property type="entry name" value="INTERSECTIN-2 ISOFORM X1"/>
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    </dbReference>
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        </location>
    </feature>
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        <location>
            <begin position="1110"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1336"/>
            <end position="1347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1348"/>
            <end position="1358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1366"/>
            <end position="1377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1413"/>
            <end position="1423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1480"/>
            <end position="1494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50031"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51082"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH38532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="1897" mass="209674" checksum="DCEDAF9E2268D9A1" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J8V6</accession>
    <name>A0A2H3J8V6_WOLCO</name>
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        <recommendedName>
            <fullName evidence="4">Phorbol-ester/DAG-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WOLCODRAFT_136025</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD-104</strain>
        </source>
    </reference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="608"/>
            <end position="661"/>
        </location>
    </feature>
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        <location>
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            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
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            <end position="233"/>
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        <location>
            <begin position="204"/>
            <end position="220"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH38065.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="2333" mass="261482" checksum="135321310B946BEE" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J941</accession>
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        <submittedName>
            <fullName evidence="12">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WOLCODRAFT_135536</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD-104</strain>
        </source>
    </reference>
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        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
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        <property type="protein sequence ID" value="PCH34168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="742152.A0A2H3J941"/>
    <dbReference type="OMA" id="KATWMEC"/>
    <dbReference type="OrthoDB" id="2241241at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF91">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="302"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
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            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="413"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="439"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="12"/>
            <end position="466"/>
        </location>
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        <location>
            <begin position="498"/>
            <end position="517"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PCH34168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="517" mass="56672" checksum="AEBF9EED4329011E" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J969</accession>
    <name>A0A2H3J969_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNI-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_20484</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467876">
        <property type="protein sequence ID" value="PCH36343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J969"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="214"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH36343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="696" mass="77880" checksum="FA088DDC2CB6B756" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JB41</accession>
    <name>A0A2H3JB41_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">WOLCODRAFT_139633</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">MD-104</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467832">
        <property type="protein sequence ID" value="PCH34888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JB41"/>
    <dbReference type="STRING" id="742152.A0A2H3JB41"/>
    <dbReference type="OMA" id="EWIPGMA"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="398"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PCH34888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="462" mass="51717" checksum="0D18C9EECB13CA40" modified="2018-01-31" version="1">MGKYIWQVSKHCDVFISIGEKCPPFPGDIIHLDVLGKSLIIINSEEVAKDLLDKRSAKYSDRPRLVMAADLAGFDRFFVLQPYNDQWRSRRRIMVQGFGQTNIIAYRGIQEAAARKLASSFIDDPNNYVSHIKLNIASSIVRATYGYDAKHLDDPMIANPLKSIQNFVEASVPGTWAVDFIPQLRYLPSWLPGTEFMKVAKRMRQDGYNATWNTYLWCMNNLETSVLTPSLCASVLSNTEDALSKEDEADLAWSASTAMGGGLDTTTSVILTFILAMIHYPEVQKRAQAEIDTVIGTDKLPTISDRLSLPYVRSVIAETFRWQPPDPLSMVHSMSEADVYNGFNLPNGSMVIPNVWHMLHDPCQYPEPMIFKPERFGDDDAQMARAIRLTFGFGRRACPGSHFAEETVFAMIATILACCDISPALDAHGNAIIPDIEYTSGVVVFPKDFKCDIKPRSSQSYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JBJ5</accession>
    <name>A0A2H3JBJ5_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
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                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
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                <person name="Coutinho P.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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        </source>
    </evidence>
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</entry>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
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                <person name="Lundell T."/>
                <person name="Martin R."/>
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                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">MD-104</strain>
        </source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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                <person name="Barry K."/>
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                <person name="Yadav J.S."/>
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                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
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                <person name="Nagy L.G."/>
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                <person name="Sabat G."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
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    </feature>
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    </feature>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
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                <person name="Barry K."/>
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                <person name="Benoit I."/>
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                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
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                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
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                <person name="Morin E."/>
                <person name="Murat C."/>
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                <person name="Wiebenga A."/>
                <person name="Young D."/>
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        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
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    </evidence>
    <sequence length="477" mass="51793" checksum="56CD483E310A3908" modified="2018-01-31" version="1">MESATFFDEFMQFPSCPEQSYDDLDFLVSGISADHAPFTWDSTFDFDKSTLELPTPCDPSFAWFTDKAGDIYELDLGQDSLFADIDISDYAHLDVTTEKEGKHCDTQSPAIDIAPIDSAPLKSLCSLEAGQPVDITCSTASPPRCANYAQASASTSKGQGYVYPVEVLPSTSYASPAAPIPPIQNPAHEQSVAYASGTYGAGYAPSTISPTLMHRGATLHPSPSYSHCTPSTEYSTAMSSPPSLTYSDSSDDSFAESDNSDEDADPWLLAPRKRSGRYQPYTPCSCVHSSKTKRARSYSAPSSAHHSAPSVSHSFPSVSYQPSSSRIDARRFEPVLSTGPAVAANPRNAQVHITPAQAQWAVENLACPVPGCAYEQANQRPADMRRHLRSHGYMDSEREWVCCGVPVAQAAKLGMAAEEIAARKTVYQGVEVVGGCMRTFSRRDSLRRHFKNRRSGCCGDLRFICSLVAKRSDDNAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JEW7</accession>
    <name>A0A2H3JEW7_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_155201</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467832">
        <property type="protein sequence ID" value="PCH34537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JEW7"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013816811" evidence="1">
        <location>
            <begin position="17"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH34537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="107" mass="11819" checksum="BBAB5F69938189DC" modified="2018-01-31" version="1">MKTFYLFNLWATPLSAVTLSRFLLDLRLCSVSPESPRIEEQTESDTAYSENQDYSIHLSTFVSTVGTAPKPESQANSSANYEAVSTPGRVCSSHIGKAHVHAEFYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JG09</accession>
    <name>A0A2H3JG09_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Diphthine--ammonia ligase</fullName>
            <ecNumber evidence="2">6.3.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Diphthamide synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Diphthamide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WOLCODRAFT_143406</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>diphthine-[translation elongation factor 2] + NH4(+) + ATP = diphthamide-[translation elongation factor 2] + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19753"/>
            <dbReference type="Rhea" id="RHEA-COMP:10172"/>
            <dbReference type="Rhea" id="RHEA-COMP:10174"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16692"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:82696"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.1.14"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.14" evidence="2"/>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH41130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JG09"/>
    <dbReference type="STRING" id="742152.A0A2H3JG09"/>
    <dbReference type="OMA" id="HCRLAQS"/>
    <dbReference type="OrthoDB" id="686384at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017178">
        <property type="term" value="F:diphthine-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01994">
        <property type="entry name" value="AANH_PF0828-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06155">
        <property type="entry name" value="eu_AANH_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000145">
        <property type="entry name" value="ATP-binding domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1490.10:FF:000001">
        <property type="entry name" value="Diphthine--ammonia ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1490.10">
        <property type="entry name" value="putative n-type atp pyrophosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002761">
        <property type="entry name" value="Diphthami_syn_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030662">
        <property type="entry name" value="DPH6/MJ0570"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00290">
        <property type="entry name" value="MJ0570_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12196:SF2">
        <property type="entry name" value="DIPHTHINE--AMMONIA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12196">
        <property type="entry name" value="DOMAIN OF UNKNOWN FUNCTION 71 DUF71 -CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01902">
        <property type="entry name" value="Diphthami_syn_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Diphthamide synthase" evidence="10">
        <location>
            <begin position="1"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PCH41130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="687" mass="74330" checksum="0C104386A37EA397" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JG26</accession>
    <name>A0A2H3JG26_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-hydroxyisobutyryl-CoA hydrolase</fullName>
            <ecNumber evidence="2">3.1.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WOLCODRAFT_22787</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-methylpropanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20888"/>
            <dbReference type="ChEBI" id="CHEBI:11805"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57340"/>
            <dbReference type="EC" id="3.1.2.4"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.1.2.4" evidence="2"/>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH37709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JG26"/>
    <dbReference type="STRING" id="742152.A0A2H3JG26"/>
    <dbReference type="OMA" id="EVFTMEY"/>
    <dbReference type="OrthoDB" id="1737613at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003860">
        <property type="term" value="F:3-hydroxyisobutyryl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045004">
        <property type="entry name" value="ECH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032259">
        <property type="entry name" value="HIBYL-CoA-H"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004127">
        <property type="entry name" value="PRK05617.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43176:SF3">
        <property type="entry name" value="3-HYDROXYISOBUTYRYL-COA HYDROLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43176">
        <property type="entry name" value="3-HYDROXYISOBUTYRYL-COA HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16113">
        <property type="entry name" value="ECH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl-CoA hydratase/isomerase" evidence="4">
        <location>
            <begin position="26"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PCH37709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="473" mass="51919" checksum="A1C6A67BE8164B29" modified="2018-01-31" version="1">MSASAKVKTSSDEAPVLFKSDGCLRQYVLNRPLKLNALNEEMLNILRPKIEEWSQGKLPGIIVGTGVGRGFCAGGDVATVVLDAANPDTLPKAVGFFHREFEMDYILAAMPKPYVAVMDGITMGGGVGLAVNAPFRIATENTVFAMPETKIGYCPDVGASYFLPRVDGEIGTYLSLTSETLKGRAVYEHGFATHFVPSRRIPGLLERIASMEDPTGDQLDRLISEHSADQLPQGLDSPLVGATRVALDAAFGHDTVEEILIDLNKIAQDNAKNDDVRAWAKQTFETLHLRSPTSLKVALAAVRRGKSMTLLEALQMEVNIATAFCHGASPDFRTGVDHVLITKVKDQPRPRWSPGSVEEVPAEFIEREFFTNYTPEQSTAPRLQVPEWLAGHTKLISPMQYALPSEEEIRHMVDGSHASSGSTALTLDEVVAKFVALKNGKEGVKEKVLEVVGRRCYEDPDKHTDKKWLKWIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JGE7</accession>
    <name>A0A2H3JGE7_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribonucleotide reductase small subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_71522</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribonucleoside diphosphate reductase small chain family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH41270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JGE7"/>
    <dbReference type="STRING" id="742152.A0A2H3JGE7"/>
    <dbReference type="OMA" id="NTIPCVA"/>
    <dbReference type="OrthoDB" id="10248373at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009263">
        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01049">
        <property type="entry name" value="RNRR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="entry name" value="Ribonucleotide Reductase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033909">
        <property type="entry name" value="RNR_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030475">
        <property type="entry name" value="RNR_small_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000358">
        <property type="entry name" value="RNR_small_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409:SF18">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00268">
        <property type="entry name" value="Ribonuc_red_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00368">
        <property type="entry name" value="RIBORED_SMALL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH41270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="376" mass="43639" checksum="1D0E5630B1BF73B2" modified="2018-01-31" version="1">MSYASTSKTIIHELNDGALKQGNSQPLQEVDFDTVQPEDDHDLRQRFVGEVDLPEHMEPLLTESWRRFVLFPIQYHDIWQMYKKAEASFWTAEEIDLSHDLWDWKLRLNDDERHFISHVLAFFAASDGIVNENLVERFSNEVQAAEARCFYGFQIMMENIHSETYSLLIDTYIKDQAQRERLFDAIETIPCIKKKADWALRWISDKRSCFAERLVAFAAVEGIFFSGSFAAIFWLKKRGLMPGLTFSNELIIRDEGMHTDFACLLYSHLRRRLHPRVILKIVTEAVTIEQEFLSEALPCALIGMNVKLMCQYIEFVADRLLVSLGNDKHYNVTNPFDFMDMISMQGKTNFFEKRVSDYAKAGVKASTDKPTAEKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JGK2</accession>
    <name>A0A2H3JGK2_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WOLCODRAFT_150698</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH40675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JGK2"/>
    <dbReference type="STRING" id="742152.A0A2H3JGK2"/>
    <dbReference type="OMA" id="GCAHSGR"/>
    <dbReference type="OrthoDB" id="3263571at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005162">
        <property type="entry name" value="Retrotrans_gag_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032567">
        <property type="entry name" value="RTL1-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503">
        <property type="entry name" value="LDOC1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503:SF22">
        <property type="entry name" value="TRANSPOSON TY3-I GAG POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03732">
        <property type="entry name" value="Retrotrans_gag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="5">
        <location>
            <begin position="239"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="192"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="246"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="89"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="253"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="273"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PCH40675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="323" mass="37272" checksum="FC6360D656715D6F" modified="2018-01-31" version="1">MIKINPPDVFNGERSDMQNFINQCSSWFTMYEMSFQNDIQRVIFILSYISGKGKTGQWKQNYHRVHTDPTTRRFFPPSLAQFDADFQKAFRAVQEIQKAQRQILKLEQDKKDIDDYITEFNNMAGKAQYDRYSPDGNALLITLFEKGLLDHTTRYIIGMRPMPDNIDAWQEAASYYENTYKIFLRRDKRAQVKKKDWRSSTPRHSGNTSASTSTSKDPNMMDVDRLTAEERQDHITKGKCFNCHQPGHLSRTCPKKKKGTGRPRGKARKAEEDSPEPDTTIEETSDEGEVEYITANQAVTAIRTLKAKNPALLSKLLDETDFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JGQ1</accession>
    <name>A0A2H3JGQ1_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phospho-2-dehydro-3-deoxyheptonate aldolase</fullName>
            <ecNumber evidence="6">2.5.1.54</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WOLCODRAFT_162487</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4 6">
            <text>D-erythrose 4-phosphate + phosphoenolpyruvate + H2O = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14717"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="2.5.1.54"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Cd(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48775"/>
        </cofactor>
        <text evidence="5">Binds 1 divalent cation per subunit. The enzyme is active with manganese, cobalt or cadmium ions.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 1/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the class-II DAHP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.54" evidence="6"/>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH40725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JGQ1"/>
    <dbReference type="STRING" id="742152.A0A2H3JGQ1"/>
    <dbReference type="OMA" id="FKVMMQM"/>
    <dbReference type="OrthoDB" id="2338at2759"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00084"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003849">
        <property type="term" value="F:3-deoxy-7-phosphoheptulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002480">
        <property type="entry name" value="DAHP_synth_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21337:SF0">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21337">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE 1, 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01474">
        <property type="entry name" value="DAHP_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0104">Cadmium</keyword>
    <keyword evidence="5" id="KW-0170">Cobalt</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="345"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="377"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="419"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="455"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602480-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PCH40725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="499" mass="55291" checksum="4D8EC0A72F58C76E" modified="2018-01-31" version="1">MSVDPWTPSSWKNKPAAQDVVYPDREKLDKVLAKIQTLPPLVTPSEIERLRHKLGQVQRNEAFLLHAGDCAESFDACTHENLSNKIGLILSFSLILIWGARMPVVRIGRIAGQYAKPRSSPTEKIGDREVLSFRGDNVNGLDPNDRTPDPERLLSAYFHSTTTLNYVRALLTSGFASLHHPRDWSLSHVRSPALREEFEKMTEGLSDALDFTRTIGFGAHQTSYEQGGGRGVLGEVDFFTSHEGLMLDFEEAMTRKFPISSSLQSTSQAASPERPPNVYYNTSAHFLWIGDRTRQLTGAHVEYFRGIRNPIGIKVGPSMAADEIVRLLDIVNPDREEGKVTLITRYGAGKIETHLAGHILAVQKSGHPVAWICDPMHGNTLTSSSGLKTRHFGTIISELTSCIRIHAECGSRMNGVSLEFTGELSEDGFSVTECVGGSMELSEEQLGLRYQSFCDPRLNFEQSLDVAFLISNSYKKARLGRKPADSDVLYSELGGRKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JGV3</accession>
    <name>A0A2H3JGV3_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HSF-type DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WOLCODRAFT_100521</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the HSF family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH41420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JGV3"/>
    <dbReference type="STRING" id="742152.A0A2H3JGV3"/>
    <dbReference type="OMA" id="ENQHMIR"/>
    <dbReference type="OrthoDB" id="432483at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF427">
        <property type="entry name" value="HEAT SHOCK FACTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
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<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JJ86</accession>
    <name>A0A2H3JJ86_WOLCO</name>
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        <submittedName>
            <fullName evidence="2">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_135860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH37808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JJ86"/>
    <dbReference type="STRING" id="742152.A0A2H3JJ86"/>
    <dbReference type="OMA" id="CGSAITY"/>
    <dbReference type="OrthoDB" id="1706066at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05188">
        <property type="entry name" value="MDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052711">
        <property type="entry name" value="Zinc_ADH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033:SF3">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G13270)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="26"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH37808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="371" mass="39556" checksum="D4B749158CA9C9DF" modified="2018-01-31" version="1">MSSSQMPAVTKAIVMRKSQRKPVYHDTVLEERPLPALQKGQVLVKVAAAGFNHRDVWIRQGQYPNIRFGSVMGSDAAGTVIAAADSNDPLLNKRVFLVPMRGWEQHPDAPESSDFTIMGGSGPIPIGAFAQHIVVERDQVIPTPSHLSDEHIAAWPVGGVTAWRAAIVNARVQKGDNVLVTGIGGGVALLAMQFCLARGANVYVTSGSEEKIRKAVALGAKAGVSYKADNWPAQLAKILQSNSSSSAPNAALLSAIIDSGGGDLTVKVNKILKPGGRVAVYGMTAYPTMSFTMREVLKNQQLIGSTMGSHQDLIDATNFIAEHRIVPVVSHIIDGLEAAEEGFELIKKGEQFGKVVIRIGNGRVTGERAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JJH8</accession>
    <name>A0A2H3JJH8_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GroES-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_25320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468124">
        <property type="protein sequence ID" value="PCH42350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JJH8"/>
    <dbReference type="STRING" id="742152.A0A2H3JJH8"/>
    <dbReference type="OMA" id="MIASNKY"/>
    <dbReference type="OrthoDB" id="9930022at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08276">
        <property type="entry name" value="MDR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052711">
        <property type="entry name" value="Zinc_ADH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C1773.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="17"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH42350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="318" mass="34444" checksum="D40E7D2737DB4D5F" modified="2018-01-31" version="1">MPIPTTTREYRLPKVDGFHNLTLQEAPLRTPKSSEVLVKIHAVSFQYRDLIVAKGQYPLSQKENPVPGPDMAGEIIATGGDVKGWKVGDRVCANFALDHVFGDATDESKATGLGAPIDGVLTEYRLFPAHSCAMLTTYNALKGLRPLKGGDYVRVQGTGGVSIFGLQFAVASGATVIATSSSDKKPEITKKLGARHLINYKTPDWEKEVLKIMLIEVGGPGTIMKSLASVRYAGIANAIGFGGDMSSLPVAILGKSSIVRGILIGSRTQFKDMNRPIVAQNLEPVIDRVFSFEDVRTAYEYQESRQHVGKVVTRVPED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JK20</accession>
    <name>A0A2H3JK20_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MMS19 nucleotide excision repair protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WOLCODRAFT_140364</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the MET18/MMS19 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467876">
        <property type="protein sequence ID" value="PCH36357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JK20"/>
    <dbReference type="STRING" id="742152.A0A2H3JK20"/>
    <dbReference type="OMA" id="FSFMPEF"/>
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                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
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        </source>
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        </source>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH38408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="167" mass="18306" checksum="941F080D3C4CAFB8" modified="2018-01-31" version="1">MSRLPPEIQGGVQEWRHRRRDPISCPTGPATCAPPPTGSRAAYAVPATPPQRAHAASWCGGRRAALGGREHWNPAGGRAYGMSDTTHREPVRDQRTRVNVAHIAIRAGPDASTARRGRPRAHVRASASDASDYTAQQGRARQGDERSQRQISGLYYEISERQVPSRR</sequence>
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                <person name="Kallen N."/>
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            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="376" mass="40840" checksum="27160B14A6DA38D2" modified="2018-01-31" version="1">MSTSGRTPSTPIRPFRIQAPITPSSSFTPEQRQRRRDLLNAASKLNPTSRMDNINAGLRGRTTNQVLTQRPDGSTASAHDAAAATLGQGRAHQMPGDIGGRSPPPKRSRTDDCDAEYDTNFDSEPPSPVRSLHSAGVQADISPGIADSRQLPPDEELVIGPDIDDQDELWDTSFDGDKSISSHYATAPPSPGEPPFGLSTEPVAGPSVPRQPSLSASQLLGLLTPPTSSQLGFEFEGAFSQPIDEAPDSPSKGKGKGRDLGIAAMQRHVPHGEIQKTIKERLRNPSPDDRQTPQSSPPSGPPQLHEQAAADLPTKMQATFSEYIDYVRRLERREKAAFMSNELKMNKIKQLESENEELRRRIRALGATIAALEARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JN87</accession>
    <name>A0A2H3JN87_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="7">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WOLCODRAFT_88588</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="7"/>
    <dbReference type="EMBL" id="KB468053">
        <property type="protein sequence ID" value="PCH40269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JN87"/>
    <dbReference type="STRING" id="742152.A0A2H3JN87"/>
    <dbReference type="OMA" id="CKYPGKA"/>
    <dbReference type="OrthoDB" id="10261556at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17920">
        <property type="entry name" value="DEXHc_RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004589">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032284">
        <property type="entry name" value="RecQ_Zn-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00614">
        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF152">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE Q5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16124">
        <property type="entry name" value="RecQ_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="46"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="247"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="509"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="517"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PCH40269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="758" mass="84591" checksum="5B46FF021541F7C9" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JNM6</accession>
    <name>A0A2H3JNM6_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Transcription regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WOLCODRAFT_26188</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468146">
        <property type="protein sequence ID" value="PCH43780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="742152.A0A2H3JNM6"/>
    <dbReference type="OMA" id="WVQIRDD"/>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034728">
        <property type="term" value="P:nucleosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18659">
        <property type="entry name" value="CD2_tandem"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000130">
        <property type="entry name" value="Chromodomain-helicase-DNA-binding protein 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
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    </dbReference>
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        </location>
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        <location>
            <begin position="399"/>
            <end position="568"/>
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        <location>
            <begin position="696"/>
            <end position="852"/>
        </location>
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            <begin position="1"/>
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        </location>
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        </location>
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        </location>
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        </location>
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            <begin position="1"/>
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            <dbReference type="EMBL" id="PCH43780.1"/>
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</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JNP3</accession>
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        <name evidence="2" type="ORF">WOLCODRAFT_153176</name>
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        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
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                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
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                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
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                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
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                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">MD-104</strain>
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        </location>
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        <source>
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    </evidence>
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            <dbReference type="EMBL" id="PCH43115.1"/>
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</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
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        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
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                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
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                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
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                <person name="Murat C."/>
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                <person name="Nolan M."/>
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                <person name="Patyshakuliyeva A."/>
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                <person name="Sabat G."/>
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                <person name="Stenlid J."/>
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                <person name="Wiebenga A."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MD-104</strain>
        </source>
    </reference>
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        <reaction evidence="16">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
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            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="term" value="P:chitin biosynthetic process"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="CHS4-like_dom"/>
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        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
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        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CHITIN SYNTHASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Chitin_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22997">
        <property type="entry name" value="CHS4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="332"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="815"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="846"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="872"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin synthase 4-like" evidence="13">
        <location>
            <begin position="237"/>
            <end position="319"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
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        <location>
            <begin position="1051"/>
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        </location>
    </feature>
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        <location>
            <begin position="1"/>
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    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF22997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PCH43842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="1133" mass="124598" checksum="134EFDA1E79F3BE4" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JNV8</accession>
    <name>A0A2H3JNV8_WOLCO</name>
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        <recommendedName>
            <fullName evidence="8">Fanconi-associated nuclease</fullName>
            <ecNumber evidence="8">3.1.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WOLCODRAFT_113993</name>
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    <organism evidence="11 12">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD-104</strain>
        </source>
    </reference>
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        <text evidence="8">Nuclease required for the repair of DNA interstrand cross-links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions.</text>
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    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>Hydrolytically removes 5'-nucleotides successively from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides.</text>
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        </reaction>
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    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the FAN1 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008409">
        <property type="term" value="F:5'-3' exonuclease activity"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070336">
        <property type="term" value="F:flap-structured DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:phosphodiesterase I activity"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="FAN1-like_TPR"/>
    </dbReference>
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        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="VRR_NUC"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="FANCONI-ASSOCIATED NUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21170">
        <property type="entry name" value="FAN1_TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08774">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00990">
        <property type="entry name" value="VRR_NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 8" id="KW-0464">Manganese</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="329"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="467"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="467"/>
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        </location>
    </feature>
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        <location>
            <begin position="482"/>
            <end position="492"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00000983"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00005533"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PCH37697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="551" mass="62954" checksum="3A2F29A7F74BE6F1" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JNW4</accession>
    <name>A0A2H3JNW4_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_153933</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468146">
        <property type="protein sequence ID" value="PCH43882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        </source>
    </evidence>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
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                <person name="Ferreira P."/>
                <person name="Findley K."/>
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                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
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                <person name="St John F."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">MD-104</strain>
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    </feature>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
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                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
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                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
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                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
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                <person name="Larrondo L.F."/>
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                <person name="Martin R."/>
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                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
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                <person name="Samejima M."/>
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                <person name="Stenlid J."/>
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                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1221748"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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</entry>
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    <protein>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
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                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="PCH38674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="144"/>
        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
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        </source>
    </evidence>
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        </source>
    </evidence>
    <sequence length="144" mass="16019" checksum="693D19820BF9A7DE" modified="2018-01-31" version="1" fragment="single">MSYVDVSSIVDSGFHLIPEPDKISRYSEIAHALAPISQSASIIEHVEVSQNTFRPRGSHYSRKYLRTITMNGRTGVSVADALESKFDGLDNAKEPFFTTLGNSTKGTIRIEVYGYPPYSQQIPIRDGKRQSKALDMEKQSHAIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JPV9</accession>
    <name>A0A2H3JPV9_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_130651</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH38057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JPV9"/>
    <dbReference type="STRING" id="742152.A0A2H3JPV9"/>
    <dbReference type="OMA" id="LTFCYLH"/>
    <dbReference type="OrthoDB" id="2351920at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH38057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="185" mass="20634" checksum="8A67E2CE18ABB297" modified="2018-01-31" version="1">MTDLTYCYLHMTKHDIEVIDTIGTSDYLKGEISDDEVDIPPHMVPPNPEDSDVLPSQVHPSYPFGNPLHIKHPAAKPRRPYDPTSRALFEDMGYAGGGVNGSLRWKDLALDILYPVDEAREEAEKAAQARKLASGVSANHHPPQSGPVVQPMAEEEEEEDPEENENDENEEDEEEDESGAEEEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JQB3</accession>
    <name>A0A2H3JQB3_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acid protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WOLCODRAFT_25124</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468124">
        <property type="protein sequence ID" value="PCH42093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JQB3"/>
    <dbReference type="STRING" id="742152.A0A2H3JQB3"/>
    <dbReference type="OMA" id="MFGQKWL"/>
    <dbReference type="OrthoDB" id="660550at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013608236" evidence="2">
        <location>
            <begin position="27"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="3">
        <location>
            <begin position="59"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PCH42093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="380" mass="39727" checksum="1FA988F81DA1181B" modified="2018-01-31" version="1">MFPTSETSLRAAVILGLLAASPQGFAISTLKVPLKSTIAPKMANLFNASAPLTNAALKVVATVQAGDNQTFSDVLVDTGSAILWVGGQQKYIPGADTRVINETFSVGYGAGGVNGTAYLDRVTVGEATVSSQIIGSAGYMEGFSLVEPIDGIIGLGPSGSNYGEVSGHNTTRTFVENLVAEGTISHPVFGIYVSPLSESGIPEGTGEITFGGVDQSRISGDITWLPQNDPVDFHWEFNASSFSWGDKVLATGPIYSRTDTGVLPIAVPYDAFFAILDDVPGASLDESSAIAGSITLPANVTVDSLPAMEIGIGNLNFTIPASKYIVPTSLHTTLNITDNLVHTWIMSGGPGAFDLGQKFLENAYSAYDMENHLVGFAYLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JQJ2</accession>
    <name>A0A2H3JQJ2_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TPT-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WOLCODRAFT_77218</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB468157">
        <property type="protein sequence ID" value="PCH44420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JQJ2"/>
    <dbReference type="STRING" id="742152.A0A2H3JQJ2"/>
    <dbReference type="OMA" id="PSHIDQK"/>
    <dbReference type="OrthoDB" id="1588579at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
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            <end position="257"/>
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        <location>
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            <end position="311"/>
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            <end position="42"/>
        </location>
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            <end position="403"/>
        </location>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Floudas D."/>
                <person name="Binder M."/>
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                <person name="Barry K."/>
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                <person name="Ferreira P."/>
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                <person name="Glotzer D."/>
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                <person name="Martin F."/>
                <person name="Cullen D."/>
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        </source>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
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                <person name="Martinez A.T."/>
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                <person name="Spatafora J.W."/>
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                <person name="Copeland A."/>
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                <person name="Ferreira P."/>
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                <person name="Foster B."/>
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                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
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            <strain evidence="13 14">MD-104</strain>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Cytochrome_P450_fung"/>
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        <source>
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        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JSQ8</accession>
    <name>A0A2H3JSQ8_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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        <name evidence="2" type="ORF">WOLCODRAFT_139052</name>
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        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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            <taxon>Agaricomycetes</taxon>
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            <taxon>Phaeolaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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    </feature>
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        <location>
            <position position="124"/>
        </location>
    </feature>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH44525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="124" mass="13608" checksum="E4B681382C778F95" modified="2018-01-31" version="1" fragment="single">MFPLNLVYCAVAAFSATIGYQPSKRRNRRSLAERADHVSLQEGYGNSSVKSHENAVENTSPDANSAAASDNQLLPQVSEHARDSSMTGTLKRKIRDDDSTLDLDKDNAVNTVLTLSRPSKKRCQ</sequence>
</entry>
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                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
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                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
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                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
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                <person name="Sabat G."/>
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                <person name="St John F."/>
                <person name="Stenlid J."/>
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                <person name="Sun S."/>
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                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
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                <person name="Martin F."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD-104</strain>
        </source>
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    </dbReference>
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        <property type="entry name" value="LysM_dom_sf"/>
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    </dbReference>
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        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="218" mass="21687" checksum="A38FF892DDB25CFB" modified="2018-01-31" version="1">MFSSSVVAALVALPLVAQSAYAQTCARTYTVQEGDDCDRISAANNASTYQLAVVNAGKINTGCTNLVPGESICLGWVGSDCDTTYVVSAGDDCDSVASAHGINTTVLYQNNPQLDAACDNMYIGEVLCMASDVDVPVASASGGASSVFSVATSIPPTATPVNATVAASALSSTLTAAPTSSVASASASATASATGDDGDDGDDGDDGDDGDLPWCDEL</sequence>
</entry>
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    </protein>
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            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Benoit I."/>
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                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
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                <person name="Hesse C."/>
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                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
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                <person name="Kumar T.K.A."/>
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                <person name="Larrondo L.F."/>
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                <person name="Lundell T."/>
                <person name="Martin R."/>
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                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
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                <person name="Sabat G."/>
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                <person name="Wiebenga A."/>
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                <person name="Martin F."/>
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            <dbReference type="PubMed" id="22745431"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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            <begin position="105"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="120" mass="13099" checksum="BAF74708537FB1FB" modified="2018-01-31" version="1">MLGVFNEDLAMDSWPENDKAIPIIPLTTLASRRASVWASGRPGLGKIPELPTHDGAYDGTNKGPDVPRLRSPAPIAGPSSTAAGPSASRAVSTKRRKRNWSELLPPRERHEHMAKWARQN</sequence>
</entry>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Gorecki P."/>
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                <person name="Kallen N."/>
                <person name="Kersten P."/>
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                <person name="Martin R."/>
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                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
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                <person name="Slot J.C."/>
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                <person name="Stenlid J."/>
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                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        </source>
    </evidence>
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</entry>
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            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
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                <person name="Benoit I."/>
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                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
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                <person name="Hesse C."/>
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                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
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                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
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                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
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                <person name="Rokas A."/>
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                <person name="Sun S."/>
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                <person name="Wiebenga A."/>
                <person name="Young D."/>
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                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">MD-104</strain>
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    </evidence>
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</entry>
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        </lineage>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
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                <person name="Benoit I."/>
                <person name="Boyd A."/>
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                <person name="Lucas S."/>
                <person name="Lundell T."/>
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                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
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                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
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                <person name="Stenlid J."/>
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                <person name="Wiebenga A."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
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    </feature>
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        </location>
    </feature>
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        <location>
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            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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            <end position="70"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH39557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="337" mass="35450" checksum="8FC62C67D78FE644" modified="2018-01-31" version="1">MVSLRDVSEKSLSESRPAPESESNIISSTAREMGIQLSPLTAPPEDMSFVVKTPNISSSPAHSREPSSMSCRRLASNIPALHSKLVLPPLPSFSSSPLSTTSGSHSPASITPTPLHDFLVTKSLASSLRAANLESSPNSPVTPVDQIILTPLVPPSISRSPRIRPVRKLAPLNMSIDASVLTGSVLASPDLPFTPIDGQSPLLSGTCSESKDCGLPPSPFMRWAERSSLTPVNQLRLPGEASDGKTATVASPLRTPLTPTRLVSRPRPSMPGRRFSYTSSPLMPSSNVVTADHGLASPALICALRMARECSIEDNVGSPAVRSPAPVLVEAGGYFGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JUJ9</accession>
    <name>A0A2H3JUJ9_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Thioredoxin reductase</fullName>
            <ecNumber evidence="8">1.8.1.9</ecNumber>
        </recommendedName>
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        <name evidence="11" type="ORF">WOLCODRAFT_136845</name>
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        <name type="common">Brown rot fungus</name>
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        <lineage>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
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                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
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                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
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                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>[thioredoxin]-dithiol + NADP(+) = [thioredoxin]-disulfide + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20345"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="9">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.9" evidence="8"/>
    <dbReference type="EMBL" id="KB468053">
        <property type="protein sequence ID" value="PCH40394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JUJ9"/>
    <dbReference type="STRING" id="742152.A0A2H3JUJ9"/>
    <dbReference type="OMA" id="GPCHVLK"/>
    <dbReference type="OrthoDB" id="371245at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004791">
        <property type="term" value="F:thioredoxin-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019430">
        <property type="term" value="P:removal of superoxide radicals"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000064">
        <property type="entry name" value="Thioredoxin reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050097">
        <property type="entry name" value="Ferredoxin-NADP_redctase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008255">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_2_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005982">
        <property type="entry name" value="Thioredox_Rdtase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01292">
        <property type="entry name" value="TRX_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48105">
        <property type="entry name" value="THIOREDOXIN REDUCTASE 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00469">
        <property type="entry name" value="PNDRDTASEII"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00573">
        <property type="entry name" value="PYRIDINE_REDOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 8" id="KW-0274">FAD</keyword>
    <keyword evidence="2 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 9" id="KW-0521">NADP</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7 8" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="10">
        <location>
            <begin position="25"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PCH40394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="344" mass="36849" checksum="A8C2BEA001DFFF7C" modified="2018-01-31" version="1">MAPTTNGANGTTNGKVEKSSKMHSKVVIIGSGPAGHTAAIYLARANLNPVLFEGFMANGFAAGGQLTTTTDIENFPGFPSGILGPELMDKFRAQSQRFGTNIITETVSKVDLSARPFRYWREFQEDQEPETADTLIIATGASAKRLGLKGEETYWQSGISACAVCDGAVPIFRNKPLAVIGGGDSAAEEATYLTKYGSHVYVIVRRAELRASKIMAKRLLNNPKVTILWNTIATECQGDGDLLNNLRIKNVVTGEEKDLPVNGLFYAIGHEPATALVRGQLQTDPDGYIITVPGTTQTSVKGVFAAGDVQDKRYRQAITSAGSGCMAALEAERLIAEEEEGIED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JUX2</accession>
    <name>A0A2H3JUX2_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">snRNA-activating protein complex subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WOLCODRAFT_26180</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNAPC3/SRD2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468146">
        <property type="protein sequence ID" value="PCH43773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JUX2"/>
    <dbReference type="STRING" id="742152.A0A2H3JUX2"/>
    <dbReference type="OMA" id="PCWRWMG"/>
    <dbReference type="OrthoDB" id="3437960at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019185">
        <property type="term" value="C:snRNA-activating protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003681">
        <property type="term" value="F:bent DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001046">
        <property type="term" value="F:core promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001006">
        <property type="term" value="F:RNA polymerase III type 3 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042795">
        <property type="term" value="P:snRNA transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042796">
        <property type="term" value="P:snRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022042">
        <property type="entry name" value="snRNA-activating_su3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13421">
        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13421:SF16">
        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12251">
        <property type="entry name" value="SNAPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PCH43773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="359" mass="40014" checksum="A810F73CCBE21A17" modified="2018-01-31" version="1">MHIPNSIDDLRQPLHNVITAPRLMTHVMKSHQAVVHSIYETADSSNRKKRRRTMLPEPAGERADVTALRLSMDNTRLKCWPLTIHAASFIRPPKHSDRNTLIHVKKSGMGPASSHQHEALIFITIYNKLSWNHRQLFRLSQHVLLASQTLDRLFAVIPCHWKELPQDIAGNSSTPIEYSAPSSNGSATREGTSGCVICIDGVLYGDGQNLDDYSSKLLQLYQASQNEQNGNTLRVGPTMPSTVLASLSFELHKPYWLLHAGNCEHFLVVDQIRMYHPDDPLPSAYPLTNHITPPLLDLCRACSKVPATFAVIGDVRLGESPFVICGPCWRWMGIPNGMGSEDVSVIPLPRHEHGWGGVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JVD0</accession>
    <name>A0A2H3JVD0_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Peroxidase</fullName>
            <ecNumber evidence="14">1.11.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">GP1</name>
        <name evidence="16" type="ORF">WOLCODRAFT_136670</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">MD-104</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="11 14">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="11 14">Binds 2 calcium ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
        <text evidence="11">Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 14">Belongs to the peroxidase family. Ligninase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.-" evidence="14"/>
    <dbReference type="EMBL" id="KB468053">
        <property type="protein sequence ID" value="PCH40117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JVD0"/>
    <dbReference type="STRING" id="742152.A0A2H3JVD0"/>
    <dbReference type="OMA" id="SNCLGGP"/>
    <dbReference type="OrthoDB" id="2113341at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000302">
        <property type="term" value="P:response to reactive oxygen species"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.420.10">
        <property type="entry name" value="Peroxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044831">
        <property type="entry name" value="Ccp1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002016">
        <property type="entry name" value="Haem_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001621">
        <property type="entry name" value="Ligninase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024589">
        <property type="entry name" value="Ligninase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019793">
        <property type="entry name" value="Peroxidases_heam-ligand_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356:SF66">
        <property type="entry name" value="CATALASE-PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356">
        <property type="entry name" value="THYLAKOID LUMENAL 29 KDA PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00141">
        <property type="entry name" value="peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11895">
        <property type="entry name" value="Peroxidase_ext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00462">
        <property type="entry name" value="LIGNINASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00458">
        <property type="entry name" value="PEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00435">
        <property type="entry name" value="PEROXIDASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50873">
        <property type="entry name" value="PEROXIDASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0106">Calcium</keyword>
    <keyword evidence="8 13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 11" id="KW-0349">Heme</keyword>
    <keyword evidence="7 11" id="KW-0408">Iron</keyword>
    <keyword evidence="4 11 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 14 16" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013429535" description="Peroxidase" evidence="14">
        <location>
            <begin position="18"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Plant heme peroxidase family profile" evidence="15">
        <location>
            <begin position="53"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="11">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="12">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="25"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="45"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="259"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601621-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601621-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601621-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR601621-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PCH40117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="330" mass="35501" checksum="4E324EE2DC72A7BC" modified="2018-01-31" version="1">MRACYLVLSLLAVFVAGMTQKAPECGRWYTILDEIQANLFNEGRCGNQAREAIRLTFHDGIGRSAALQASGRFGGGGADGSIIKFAHTELANPANDGLEDVVYALKHFADNHNVSYGDIIQFAGAVALSNCPGSPRLAFHFGRPQAIAPSPPNLVPSPSDSAEQLLARMEDAGFTADDTVALLAAHSLAVQRTIDPSIPGTPLDSTPGEFDAQFYLEMLLKGTAYPGKGHSSAEAKSPMKHEFRLASDAAVARHSSTACKWQSFIGDQRGLQASFRDAMLKLANQGFDDLVDCSDVIPIPRRSNRLLQYPTGKNYSDIEQFCPDVPFPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JVW2</accession>
    <name>A0A2H3JVW2_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acid protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WOLCODRAFT_88607</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468053">
        <property type="protein sequence ID" value="PCH40297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JVW2"/>
    <dbReference type="STRING" id="742152.A0A2H3JVW2"/>
    <dbReference type="OMA" id="YWGINQD"/>
    <dbReference type="OrthoDB" id="660550at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase A1" evidence="6">
        <location>
            <begin position="134"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="52"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="70"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="95"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PCH40297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="459" mass="48283" checksum="D1632EE28FE1A97B" modified="2018-01-31" version="1">MSTVVVRSLPFNTRLTVGNAREILARDRARAQKILAGVNPHGPLALREARRRHGERHDHYEHRERHHGRREHEHESEREREREREHEHKHHSGGADTGSGISTGSGTGTGTGSTGSGSSGGPVGVDVTDASVNYDATVGVGSPATDYTLLIDTGSSNTWVGADKAYVKTSTSKSTGDTVNVSYGSGSFSGTEYTDTVTLASQLVITNQSIGVASSAQGFSGVDGILGVGPVDLTQGTVSNTNEVPTVTDNLYSQGTISTESLGISFEPSTSAEVANGELTFGGTDSTRHTGSITYTPITTTSPASLYWGINQDVSYGTGTTLLSGNAGIVDTGTTLLLLASDAFSKYQSATGATLDNTTGLLTITESQYEALQSLYFTIGGTTFEFTANAQIWPRALNTQIGGESGKIYLVASNLGSESGQGLDFINGFAWLQRFYSVFDTTNAQVGLANTQYTDATTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JWM1</accession>
    <name>A0A2H3JWM1_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Uridine kinase</fullName>
            <ecNumber evidence="7">2.7.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WOLCODRAFT_132271</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>cytidine + ATP = CMP + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24674"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17562"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.48"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>uridine + ATP = UMP + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16825"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16704"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.48"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Pyrimidine metabolism; CTP biosynthesis via salvage pathway; CTP from cytidine: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uridine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the uridine kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.48" evidence="7"/>
    <dbReference type="EMBL" id="KB468124">
        <property type="protein sequence ID" value="PCH42248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JWM1"/>
    <dbReference type="STRING" id="742152.A0A2H3JWM1"/>
    <dbReference type="OMA" id="EPQLHCE"/>
    <dbReference type="OrthoDB" id="738517at2759"/>
    <dbReference type="UniPathway" id="UPA00574">
        <property type="reaction ID" value="UER00637"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00579">
        <property type="reaction ID" value="UER00640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043771">
        <property type="term" value="F:cytidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004849">
        <property type="term" value="F:uridine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044211">
        <property type="term" value="P:CTP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044206">
        <property type="term" value="P:UMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02023">
        <property type="entry name" value="UMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002070">
        <property type="entry name" value="Uridine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000010">
        <property type="entry name" value="Uridine-cytidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006083">
        <property type="entry name" value="PRK/URK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000764">
        <property type="entry name" value="Uridine_kinase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004018">
        <property type="entry name" value="PRK05480.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00235">
        <property type="entry name" value="udk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10285">
        <property type="entry name" value="URIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00485">
        <property type="entry name" value="PRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14681">
        <property type="entry name" value="UPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00988">
        <property type="entry name" value="URIDINKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribulokinase/uridine kinase" evidence="8">
        <location>
            <begin position="63"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="9">
        <location>
            <begin position="302"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF14681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PCH42248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="531" mass="59315" checksum="99639974EE18F460" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JWQ8</accession>
    <name>A0A2H3JWQ8_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Vps52-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WOLCODRAFT_131732</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS52 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH41154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JWQ8"/>
    <dbReference type="STRING" id="742152.A0A2H3JWQ8"/>
    <dbReference type="OMA" id="PIRTSMT"/>
    <dbReference type="OrthoDB" id="19482at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007258">
        <property type="entry name" value="Vps52"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048361">
        <property type="entry name" value="Vps52_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048319">
        <property type="entry name" value="Vps52_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14190">
        <property type="entry name" value="SUPPRESSOR OF ACTIN MUTATIONS 2/VACUOLAR PROTEIN SORTING 52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14190:SF7">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 52 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20655">
        <property type="entry name" value="Vps52_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04129">
        <property type="entry name" value="Vps52_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vps52 coiled-coil" evidence="7">
        <location>
            <begin position="30"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Vps52 C-terminal" evidence="8">
        <location>
            <begin position="276"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="Vps52 C-terminal" evidence="8">
        <location>
            <begin position="396"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="326"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="326"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PCH41154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="606" mass="67329" checksum="06D599F9C7585A16" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JXC1</accession>
    <name>A0A2H3JXC1_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WOLCODRAFT_154668</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468168">
        <property type="protein sequence ID" value="PCH44633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JXC1"/>
    <dbReference type="STRING" id="742152.A0A2H3JXC1"/>
    <dbReference type="OMA" id="AMETIPX"/>
    <dbReference type="OrthoDB" id="3884315at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005162">
        <property type="entry name" value="Retrotrans_gag_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032567">
        <property type="entry name" value="RTL1-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503">
        <property type="entry name" value="LDOC1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503:SF22">
        <property type="entry name" value="TRANSPOSON TY3-I GAG POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03732">
        <property type="entry name" value="Retrotrans_gag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="5">
        <location>
            <begin position="223"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="176"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="235"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="73"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="237"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="257"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PCH44633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="307" mass="35399" checksum="6CE5DE35B8A6DF33" modified="2018-01-31" version="1">MQNFINQCNSWFTMYETSFQNDIQRVIFILSYISGKGKTGQWKQNYHRVHTDPTTRRFFPPSLAQFDADFQKAFGAVQEIQKARRQILKLEQDKKDIDDYITEFNNMAGKAQYDRYSPDGNALLITLFEKGLPDHTTRYIIGMRPMPDNIDAWQEAASYYENTYKIFLRRDKGAQVKKKDWRSSTPRHSGNTSTSTPTSKDPNAMDIDRLTAEERQDHITKGKCFNCHQPGHLSRYCPKRKKGTGRSKGKARKAEEDRSEPDAAIEEVSDEGETEFITANRAITAIRTLKAKDPELLSKLLDETDFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JXC2</accession>
    <name>A0A2H3JXC2_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Mannose-1-phosphate guanylyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WOLCODRAFT_26009</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468146">
        <property type="protein sequence ID" value="PCH43549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JXC2"/>
    <dbReference type="STRING" id="742152.A0A2H3JXC2"/>
    <dbReference type="OMA" id="WSDLGNF"/>
    <dbReference type="OrthoDB" id="5594057at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004475">
        <property type="term" value="F:mannose-1-phosphate guanylyltransferase (GTP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009298">
        <property type="term" value="P:GDP-mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02509">
        <property type="entry name" value="GDP-M1P_Guanylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049577">
        <property type="entry name" value="GMPP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054566">
        <property type="entry name" value="ManC/GMP-like_b-helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051161">
        <property type="entry name" value="Mannose-6P_isomerase_type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46390">
        <property type="entry name" value="MANNOSE-1-PHOSPHATE GUANYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46390:SF1">
        <property type="entry name" value="MANNOSE-1-PHOSPHATE GUANYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22640">
        <property type="entry name" value="ManC_GMP_beta-helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159283">
        <property type="entry name" value="Guanosine diphospho-D-mannose pyrophosphorylase/mannose-6-phosphate isomerase linker domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleotidyl transferase" evidence="2">
        <location>
            <begin position="133"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="MannoseP isomerase/GMP-like beta-helix" evidence="3">
        <location>
            <begin position="439"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="30"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PCH43549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="493" mass="53075" checksum="F82C3DFA5A202985" modified="2018-01-31" version="1">MSSNALSLKPAAQAGGVPVELMFNQILEAVHKSHSEIAELRAECHELRQANATLERLMREGMQYNNGSRLGTPGFVTPAPGSPQLRAKSPFLSPASIPVLAVPPSVYVPSPLSDHALTAFPFGVRDIPGFYVVIPAGGAGTRLWPLSREEHPKFLLDLTLKGRSLIQATWDRLLPLSSATRTTIVAGPAHVRSIKEQLPDLLHHNLFCEPSAKDSMAAIGLAAAVLAKRDENAVIGSFAADHMISGDDAFLSAVAEAVEVAKKDYLVTIGIAPSHPSTGFGYVRLGEKLALADAPNARLVSSFKEKPDARTAAAYIKTGIYRWNAGMFVTKAAFLMELLKEYKPELHDGLQKIAACWDDEKLRQKTLDEVWPGLEKIAIDHAVAEPAAMDRRVAVVPATFGWDDVGDFSSLADLLPAESNQPRILGDSTLVLTEQAAGGIVVPGSGRLVSLLGVDDLIIVDMPDTLLVTTRARSQEVKRLVKKCKEAGFKNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JY18</accession>
    <name>A0A2H3JY18_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WOLCODRAFT_133416</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat NOL10/ENP2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468168">
        <property type="protein sequence ID" value="PCH44883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="273340at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Beta-prop_NOL10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040382">
        <property type="entry name" value="NOL10/Enp2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056550">
        <property type="entry name" value="NOL10_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012580">
        <property type="entry name" value="NUC153"/>
    </dbReference>
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        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
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    <dbReference type="PANTHER" id="PTHR14927">
        <property type="entry name" value="NUCLEOLAR PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14927:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 10"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="NOL10_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Nucleolar protein 10-like N-terminal" evidence="9">
        <location>
            <begin position="22"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleolar protein 10-like second" evidence="8">
        <location>
            <begin position="408"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="NUC153" evidence="7">
        <location>
            <begin position="547"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
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            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
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        </location>
    </feature>
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        <location>
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    </feature>
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        <location>
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    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
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    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00005264"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF08159"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF23097"/>
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    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PCH44883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="799" mass="88803" checksum="0ECA5C9EE83623BD" modified="2018-01-31" version="1"> </sequence>
</entry>
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        <submittedName>
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        </lineage>
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    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
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                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
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                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD-104</strain>
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    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
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    <dbReference type="EMBL" id="KB468157">
        <property type="protein sequence ID" value="PCH44089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0015031">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="9">
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    <feature type="transmembrane region" description="Helical" evidence="9">
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    <feature type="transmembrane region" description="Helical" evidence="9">
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    <feature type="transmembrane region" description="Helical" evidence="9">
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    <feature type="transmembrane region" description="Helical" evidence="9">
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        <location>
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        </location>
    </feature>
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        <location>
            <position position="768"/>
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    </feature>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PCH44089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="768" mass="85705" checksum="0739BCFBB08F46DA" modified="2018-01-31" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JZ21</accession>
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        <submittedName>
            <fullName evidence="15">Cytochrome P450</fullName>
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    </protein>
    <gene>
        <name evidence="15" type="ORF">WOLCODRAFT_133102</name>
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    <organism evidence="15 16">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">MD-104</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468157">
        <property type="protein sequence ID" value="PCH44159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="742152.A0A2H3JZ21"/>
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    <dbReference type="OrthoDB" id="2789670at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="438"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PCH44159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="512" mass="56980" checksum="40FEAB9234E12FCA" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JZP8</accession>
    <name>A0A2H3JZP8_WOLCO</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_76096</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468146">
        <property type="protein sequence ID" value="PCH43358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JZP8"/>
    <dbReference type="STRING" id="742152.A0A2H3JZP8"/>
    <dbReference type="OMA" id="EHTHARD"/>
    <dbReference type="OrthoDB" id="2636278at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH43358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="266" mass="29999" checksum="C438890D89EB44DD" modified="2018-01-31" version="1">MGHRRTWDEFDAILDTPSKRIRLMTAGIASTASGSFLLSKTPINAMHNIAPPVLERVPMQLPNPDWGMLQQPSGQQSHTEMQHKIDRLTENLHLAHEHTHARDAIIEGAHAQLVIQDMYGEKLNQALYTKEHRSETDRTKLFPEGRGRHLNNVGFIEELDRVDKVRRKSSEAKGQRKMAKQQKKVEKELIEPRWKGILTQHKRAVDGWKQECERLIMEGVAKKDLPKPPKQPLKPKPAVGQADTAMNQAGGNTADVGDDVSSDGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K007</accession>
    <name>A0A2H3K007_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WOLCODRAFT_75332</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB468146">
        <property type="protein sequence ID" value="PCH43458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K007"/>
    <dbReference type="STRING" id="742152.A0A2H3K007"/>
    <dbReference type="OMA" id="WGTINGT"/>
    <dbReference type="OrthoDB" id="10252171at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
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</entry>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
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                <person name="Lucas S."/>
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                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
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            <dbReference type="DOI" id="10.1126/science.1221748"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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</entry>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
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                <person name="Henrissat B."/>
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                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
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                <person name="Benoit I."/>
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                <person name="Ferreira P."/>
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                <person name="Nagy L.G."/>
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                <person name="Ohm R.A."/>
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                <person name="Sabat G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
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    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH44814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="55" mass="6639" checksum="0D121AC13F59D399" modified="2018-01-31" version="1">MSDYQRNYTTKRRQETTDRVAYLSHCIAKTLYCILEKEVKKLKARPRRPRRVGPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K7I0</accession>
    <name>A0A2H3K7I0_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histone deacetylase</fullName>
            <ecNumber evidence="3">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WOLCODRAFT_133467</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histone deacetylase family. HD type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="3"/>
    <dbReference type="EMBL" id="KB468168">
        <property type="protein sequence ID" value="PCH45034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K7I0"/>
    <dbReference type="STRING" id="742152.A0A2H3K7I0"/>
    <dbReference type="OMA" id="DVPAGNM"/>
    <dbReference type="OrthoDB" id="73273at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF14">
        <property type="entry name" value="HISTONE DEACETYLASE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="10">
        <location>
            <begin position="24"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PCH45034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="403" mass="43407" checksum="312CC0FCA86B9FC6" modified="2018-01-31" version="1">MSSRRVVYVVSNELVKYASLLPSNRNRSLIVHSLVKAFGLLGDLQDDGQGACVRVIRPYPAGARDLTAYHSRDYVEFLLNPETTSSLLANSSGHAEYGLEEDCPPFKGLPEYARLVAGASLAAATALRDGHADIAICWDGGRHHAHKSQASGFCYIADCILAILAMKRASIPSQPYPRKPRIMYLDLDLHFSDGVSQAFWSSASVRAGGAVPQVLTLSIHHAAPGFFPASPLASLPNVEDASFDPFTLSIPLAKGASGTTFARIWPAVERAKDAFGPDFVVVQCGVDGLAGDPNGVWNWSLGDSDGSLGWCISRVCGHWKCKTLLLGGGGYNSPNAARAWTYLTSIALGHPLSLDANIPDHAAYPLYEHSFTLDVPQGNAQDQNSDEYLSEVEINDHTEPWSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K8T0</accession>
    <name>A0A2H3K8T0_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NADP+-dependent D-mannitol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WOLCODRAFT_27107</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD-104</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468168">
        <property type="protein sequence ID" value="PCH44857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K8T0"/>
    <dbReference type="STRING" id="742152.A0A2H3K8T0"/>
    <dbReference type="OMA" id="LLPCFQC"/>
    <dbReference type="OrthoDB" id="5363962at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08234">
        <property type="entry name" value="threonine_DH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050129">
        <property type="entry name" value="Zn_alcohol_dh"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43401">
        <property type="entry name" value="L-THREONINE 3-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43401:SF2">
        <property type="entry name" value="L-THREONINE 3-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="6">
        <location>
            <begin position="25"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="5">
        <location>
            <begin position="173"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PCH44857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="344" mass="37212" checksum="B9E2DD21B88AD3CE" modified="2018-01-31" version="1">MAMNAVYYKAPRDFEIREVPIPQVGDDEVLFKVVCCGVCGTDGHVHEGEFITSFPLIPGHEVVGIIAEAGKNVTGLAKGDRCVADPGVTCESCFYCRRGQSLLCENFQGKGVSSSVPGGFSEYVTFAAKKVFKIQNLTDEEATLIEPAACAIHGMDKLGTAVGVEALVIGAGPTGLILSQLLKLNGATKVTVAANKGIKTQLAKQLDAAHEYIELDRANPEPQWEQLKRDNPYGFDVVVEATGSETIANMAINYVRRGGTLMLYGVYDNAALVHYPPSKIFVDEIQIIGSFAQTHCFPRAVAYLDSGRIRVKGMVTDVFTIKDYQKALDKMNSRSALKIAVKPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3ISX2</accession>
    <name>A0A2H3ISX2_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WOLCODRAFT_58934</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH33080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3ISX2"/>
    <dbReference type="STRING" id="742152.A0A2H3ISX2"/>
    <dbReference type="OMA" id="YACEMIQ"/>
    <dbReference type="OrthoDB" id="347657at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE GREATWALL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PCH33080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="87" mass="9546" checksum="BAB00ED2DFEA7246" modified="2018-01-31" version="1" fragment="single">LEGLEALHAENIVHRDLKPESVLIGHDGHVVLSDFEHAQLPENSSSISTAQLPVIGHAFQAPELLLGWAHGPAVDWWSFGLILCYML</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3ISX5</accession>
    <name>A0A2H3ISX5_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Chorismate synthase</fullName>
            <ecNumber evidence="4 8">4.2.3.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WOLCODRAFT_134892</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21020"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="EC" id="4.2.3.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>FMNH2</name>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
        </cofactor>
        <text evidence="8">Reduced FMN (FMNH(2)).</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the chorismate synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.5" evidence="4 8"/>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH33092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3ISX5"/>
    <dbReference type="STRING" id="742152.A0A2H3ISX5"/>
    <dbReference type="OMA" id="MLSINAV"/>
    <dbReference type="OrthoDB" id="1721239at2759"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004107">
        <property type="term" value="F:chorismate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07304">
        <property type="entry name" value="Chorismate_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.150.10:FF:000004">
        <property type="entry name" value="Chorismate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.150.10">
        <property type="entry name" value="Chorismate synthase AroC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00300">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000453">
        <property type="entry name" value="Chorismate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035904">
        <property type="entry name" value="Chorismate_synth_AroC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020541">
        <property type="entry name" value="Chorismate_synthase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00033">
        <property type="entry name" value="aroC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003793">
        <property type="entry name" value="PRK05382.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21085">
        <property type="entry name" value="CHORISMATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21085:SF0">
        <property type="entry name" value="CHORISMATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01264">
        <property type="entry name" value="Chorismate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001456">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103263">
        <property type="entry name" value="Chorismate synthase, AroC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00787">
        <property type="entry name" value="CHORISMATE_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00788">
        <property type="entry name" value="CHORISMATE_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00789">
        <property type="entry name" value="CHORISMATE_SYNTHASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PCH33092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
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                <person name="Barry K."/>
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                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
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                <person name="Kuo A."/>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
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    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="93"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="132"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH33965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="533" mass="59276" checksum="754436F5715F23FF" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IXV6</accession>
    <name>A0A2H3IXV6_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WOLCODRAFT_95159</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the shaker potassium channel beta subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH34275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3IXV6"/>
    <dbReference type="STRING" id="742152.A0A2H3IXV6"/>
    <dbReference type="OMA" id="CQPYYNL"/>
    <dbReference type="OrthoDB" id="1720422at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19143">
        <property type="entry name" value="AKR_AKR6C1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005399">
        <property type="entry name" value="K_chnl_volt-dep_bsu_KCNAB-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43150">
        <property type="entry name" value="HYPERKINETIC, ISOFORM M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43150:SF2">
        <property type="entry name" value="HYPERKINETIC, ISOFORM M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01577">
        <property type="entry name" value="KCNABCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="4">
        <location>
            <begin position="30"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PCH34275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="356" mass="39751" checksum="6F88275C9194B36B" modified="2018-01-31" version="1">MTETHLEYDAKGMPFRRLGPSGLRVPVFSLGGWLTLGGTVKGDPVKDIMKVAFDHGINMFDTAEVYAEGNSEREMGRVIRELNLRRTDLIITTKLFWGRRNSPNGTGLSRKHIIEGTKASLERLGLDYVDVIFAHRPDNSVPIEETVRAFNFVINQGWAFYWATSEWSAREIEEAYHIADKFGLIPPIAEQCKHHMFHRERAEAEYAPLYRKYQIGTTVFSALASGLLTGKYNHGIPPGSRFDNHQSFFKDVIESLNEEEGLSKIAKVRALSEFAEKELGCSVAQLALAWVAVNPNTSTVILGASRPEQVLENLKALEVIPKLTPSVLEKIEGILGNKPASLPTFGRPPLDAYGRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IXY3</accession>
    <name>A0A2H3IXY3_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">T6SS Phospholipase effector Tle1-like catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_61605</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH34305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3IXY3"/>
    <dbReference type="STRING" id="742152.A0A2H3IXY3"/>
    <dbReference type="OMA" id="GWWVLEF"/>
    <dbReference type="OrthoDB" id="3162439at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018712">
        <property type="entry name" value="Tle1-like_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840:SF2">
        <property type="entry name" value="TLE1 PHOSPHOLIPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09994">
        <property type="entry name" value="T6SS_Tle1-like_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T6SS Phospholipase effector Tle1-like catalytic" evidence="2">
        <location>
            <begin position="42"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH34305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="499" mass="56678" checksum="F35E2F1466E9C4C9" modified="2018-01-31" version="1">MFPQDPHALGSQGSPPSTPDNAVLGEEIDADVVPPYCPPGQRTLVLCFDGTGDQFDTDNSNVIMLFSMLMKDRPSEQLVYYQAGIGTYTIPEIATPTYASLSKTLDEMIAWDMNAHVMGGYEFLMSNYHSGDKICLFGFSRGAYTARALAGMVHKVGLLPKGNHQQVPFAYHMFGRTDETGWKQSKAFKKCFSMDVDIDFIGVWDTVCSIGLIPRTLPFTSSNSAIRVFRHALSLDEHRAKFKANHYQWPTQEEHAKGVQHGEMPKSGPKKGLILNLRKDTQRPDQLEHERHYTARDEDQTRTDVLEVWFAGCHCDVGGGSVPNDSKHNLARIPLRWMIRECFKMNTGIRFHAEGLRSIGLDPASLWPHVQPRPPAIYSMPSLTADHARASTADTLVNGDEHPLTEEENDYIDALSPIYDQLQLAKYWWVLEVIPLEHRHKRMDGTWEDRLTINMGRGRVVPTDRPFRVHRSVKLRQDKQNYKPNAIFDEKKLDIEWVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IY44</accession>
    <name>A0A2H3IY44_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ENTH-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WOLCODRAFT_142111</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the epsin family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH34365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3IY44"/>
    <dbReference type="STRING" id="742152.A0A2H3IY44"/>
    <dbReference type="OMA" id="STEFYDI"/>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENTH" evidence="7">
        <location>
            <begin position="17"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="149"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="370"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="370"/>
            <end position="387"/>
        </location>
    </feature>
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        <location>
            <begin position="389"/>
            <end position="412"/>
        </location>
    </feature>
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        <location>
            <begin position="413"/>
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        </location>
    </feature>
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        <location>
            <begin position="425"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PCH34365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="503" mass="57071" checksum="B52D528089762455" modified="2018-01-31" version="1">MSTLTHYGKGALRVAKNYTKGYTHTQAKVRDVTSNDPWPSSGRQMHEIAQLTYNQDDFIEIMEVLDKRLNDKGKNWRHVFKSLTLLDYLLHSGSENVILYFKDNIYIIKTLREFQYVDDSDKDQGANVRQKAKDIVNLLQDETRLRHERRTRAQMYQRMSRGARGSDDSDVTDDENIARRSIIPGRRANREDDEDLRRAIEESRRSTEREHATAEERDLQRAIQLSKEDEEKRLKALGNSNLILFDEQQQTAQTNQQPLIDATLPLQYATTGIQPQYTAMLLQPQFTSFNPFQQQAQQEMLQAQYMQQQAELLTMQQAQQAQQAQELALQAQLQQAQQEEWLRQQQLQQQMQPIVPQPTSIRIGSNNPFAAALASPSSPFPRAAASAGPQLQQSSSGVEFNITGTYANRDNTSSAPPSSYQQPAVTGTRSTSWPEQQHAHLASLFANRTDDGVDTFGNVGSLRFISTEAGRVVAQKTGAANHNPFLQQSQQARQQSEGSLINF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IYG0</accession>
    <name>A0A2H3IYG0_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase C14 caspase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WOLCODRAFT_165981</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C14B family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467843">
        <property type="protein sequence ID" value="PCH35040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OMA" id="PDHERTQ"/>
    <dbReference type="OrthoDB" id="3223806at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050452">
        <property type="entry name" value="Metacaspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104:SF30">
        <property type="entry name" value="METACASPASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104">
        <property type="entry name" value="METACASPASE-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C14 caspase" evidence="3">
        <location>
            <begin position="16"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="257"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="292"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PCH35040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="482" mass="54967" checksum="4A6AE3814D2EA544" modified="2018-01-31" version="1">MVKYGPRMRTRACCQRKALLIGINYHTDMSPKGTGYDPLRGPHDDVKAFKRLLIEQFAYAEEDVVVMCDGAEEPHLQPTNVNIKHQIRRLVQGAQPGDHFVFLFSGHSDQIVCLEHSEEDGQDEVILPMDHGGLEDRDKLIVDNDIRKLLVDPLPAGAYLTAILDSCHSGTLLDLKHYRCNAIYLPWISNGERRPRSRWENVVRKDATPLTPRKPTPPPALTRVPTLTEVMKTLGWPLRKTSAQLQRSLSLRRTPTEYLDASNETASTKTAVEPPPLPRAYSQPQPPRGKWRGKEEKGEKKTEKSKEKSREKKDKELGKEKLKSLDKNKSKNNSLIKQMSLRLKTAFEIVIPQCTSPTSTVRECDGHCLASPTEKPHVISIAACADRQLDWEDSQGVSMTRALVKQLRRQPNATLAEILTTISYHNYETTYKHRSWRKQWLRCKPKGEVEMGSFPELFEYQDPQLGSQEKLDLGTQFQDYVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IYS5</accession>
    <name>A0A2H3IYS5_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WOLCODRAFT_155827</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB467843">
        <property type="protein sequence ID" value="PCH35150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3IYS5"/>
    <dbReference type="STRING" id="742152.A0A2H3IYS5"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF102">
        <property type="entry name" value="DRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G08530)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="19"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PCH35150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="127" mass="13404" checksum="D357C63AB8FDEE95" modified="2018-01-31" version="1">MAWRGHPMNCSEVGTAQNFIWLCCARAVAGIGGAGLMVVIMVMISQMVPLQERGRYMGAMYARLALTNVLGPVLGGTHTSHVHAPAADNPAQACGIAIAFILLLIHKLPDRKHTHAAESVARAPVPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IYW2</accession>
    <name>A0A2H3IYW2_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">arginine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Arginyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WOLCODRAFT_139783</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Arg) + L-arginine + ATP = L-arginyl-tRNA(Arg) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20301"/>
            <dbReference type="Rhea" id="RHEA-COMP:9658"/>
            <dbReference type="Rhea" id="RHEA-COMP:9673"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78513"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.19"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.19" evidence="2"/>
    <dbReference type="EMBL" id="KB467843">
        <property type="protein sequence ID" value="PCH35182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3IYW2"/>
    <dbReference type="STRING" id="742152.A0A2H3IYW2"/>
    <dbReference type="OMA" id="HHIGDWG"/>
    <dbReference type="OrthoDB" id="68056at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004814">
        <property type="term" value="F:arginine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006420">
        <property type="term" value="P:arginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07956">
        <property type="entry name" value="Anticodon_Ia_Arg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00671">
        <property type="entry name" value="ArgRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000006">
        <property type="entry name" value="Arginyl-tRNA synthetase 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000058">
        <property type="entry name" value="Mitochondrial arginyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.70">
        <property type="entry name" value="Arginyl tRNA synthetase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001278">
        <property type="entry name" value="Arg-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036695">
        <property type="entry name" value="Arg-tRNA-synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035684">
        <property type="entry name" value="ArgRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008909">
        <property type="entry name" value="DALR_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00456">
        <property type="entry name" value="argS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956:SF11">
        <property type="entry name" value="ARGININE--TRNA LIGASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956">
        <property type="entry name" value="ARGINYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05746">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00750">
        <property type="entry name" value="tRNA-synt_1d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01038">
        <property type="entry name" value="TRNASYNTHARG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00836">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DALR anticodon binding" evidence="12">
        <location>
            <begin position="492"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PCH35182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="612" mass="68918" checksum="8AFCF22245F8B9B1" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J098</accession>
    <name>A0A2H3J098_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_166399</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467854">
        <property type="protein sequence ID" value="PCH35662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J098"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH35662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="123" mass="11689" checksum="A6B0AE3B59F7AA82" modified="2018-01-31" version="1" fragment="single">VPIPVRRAVAGAVRAGGHASAAVPARDAAHALGGFTSARAPAPTPPIPALALKPTDQPAGVGRRSCAAAASAARACGLAHAAAAPARGEHVCTAGAAGIPVVDADACANAAATSVRDDVHVAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J1D4</accession>
    <name>A0A2H3J1D4_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_20162</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
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                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
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                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
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            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD-104</strain>
        </source>
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        <text evidence="9">Binds specifically to the 3'-terminal U-tract of U6 snRNA.</text>
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    <comment type="subunit">
        <text evidence="9">LSm subunits form a heteromer with a doughnut shape.</text>
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        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
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        <property type="protein sequence ID" value="PCH35695.1"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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    </dbReference>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="LSm4/Sm_D1/D3"/>
    </dbReference>
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        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Sm"/>
    </dbReference>
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        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23338">
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    </dbReference>
    <dbReference type="Pfam" id="PF01423">
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    </dbReference>
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        <property type="entry name" value="Sm"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
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    </dbReference>
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        <location>
            <begin position="2"/>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
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    </evidence>
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        <source>
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            <dbReference type="RuleBase" id="RU365049"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH35695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Barry K."/>
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                <person name="Yadav J.S."/>
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                <person name="Benoit I."/>
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                <person name="Ferreira P."/>
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                <person name="Kallen N."/>
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                <person name="Nagy L.G."/>
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                <person name="Ohm R.A."/>
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                <person name="Martin F."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="PCH36231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-05-03" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J370</accession>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Kallen N."/>
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                <person name="Nagy L.G."/>
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                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="PCH36682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <source>
            <dbReference type="EMBL" id="PCH36682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="82" mass="9729" checksum="25F3B44821E6243B" modified="2018-01-31" version="1">MSPCEVVEKNGWGPRHRHRHVRHTVRIGVRNTRWLGFRQRCQTAPYLRAHLAALERGNVGLKRRRSYFAFAYRSLGTCLARW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="6">Cwf15/Cwc15 cell cycle control protein</fullName>
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    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
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                <person name="Blanchette R.A."/>
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                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWC15 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467887">
        <property type="protein sequence ID" value="PCH36631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J3T6"/>
    <dbReference type="STRING" id="742152.A0A2H3J3T6"/>
    <dbReference type="OMA" id="KYREHGQ"/>
    <dbReference type="OrthoDB" id="30179at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006973">
        <property type="entry name" value="Cwf_Cwc_15"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12718">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN CWF15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12718:SF2">
        <property type="entry name" value="SPLICEOSOME-ASSOCIATED PROTEIN CWC15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04889">
        <property type="entry name" value="Cwf_Cwc_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="59"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="116"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PCH36631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="252" mass="28574" checksum="9A90F79DE228645E" modified="2018-01-31" version="1">MSTAHRPTWDPAQAKDVKGASRQFSVRDMAAHTKLKFRQPGQTSVPEVARRDLRAELLAAEQEARDKKRKAEGKPPLAVENGKDDEVNKRRKLLQEALELDKDDDDEEGSQKDEKAGDDDENDDEDDDDEDEDEEEDDTAELLRELEKIKRERAEEKERQERDQSASAAAAREAEIATANPLLNLAAALGQNPNGVNTTVPGTFAVKRRWDDDLIFKNQAMNTRDKDKASGQFVNDLLRTEFHKKFMAKFIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J4J4</accession>
    <name>A0A2H3J4J4_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">WOLCODRAFT_139528</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467832">
        <property type="protein sequence ID" value="PCH34703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J4J4"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH34703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="91" mass="9594" checksum="7893017839283077" modified="2018-01-31" version="1">MFVQGTAYSPDALVSSLKRLPKTGSGALSPSLLTLAFAQLFALLVMCLSSSLALCLLITAPLWSHTSATSGVSQRRRHSSGSLTGHRCSSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J4L9</accession>
    <name>A0A2H3J4L9_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_83675</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467909">
        <property type="protein sequence ID" value="PCH37180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J4L9"/>
    <dbReference type="STRING" id="742152.A0A2H3J4L9"/>
    <dbReference type="OMA" id="HECTANL"/>
    <dbReference type="OrthoDB" id="3269417at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH37180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="199" mass="22575" checksum="FF89532F257E4C2A" modified="2018-01-31" version="1" fragment="single">RFHLVPTFGHDTIRHFMNNVSAMKQLAARDFEDILQCIIPVFDMLLPPEHNEVVVMLLFELATWHALAKPCLHMEDNFTVFTRMTESLGDSLHAFINTTCEAYDTQELPKEHAAHGRHTATMCEQGSVISNRKKSRQGKGKGKAMDMNTSSRMANELLNGPKIKKLNLSTYKLHVLANYLQAIQQFGMTDNYSTQAISH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J595</accession>
    <name>A0A2H3J595_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">DNA polymerase</fullName>
            <ecNumber evidence="20">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">WOLCODRAFT_167138</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27 28">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 20">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="19">Forms DNA polymerase zeta with REV7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 20">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 20">Belongs to the DNA polymerase type-B family.</text>
    </comment>
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        <property type="protein sequence ID" value="PCH36835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:zeta DNA polymerase complex"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:DNA binding"/>
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    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:nucleotide binding"/>
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    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:double-strand break repair via homologous recombination"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05778">
        <property type="entry name" value="DNA_polB_zeta_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="POLBc_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.60:FF:000007">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.690:FF:000002">
        <property type="entry name" value="DNA polymerase zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA polymerase zeta catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA Polymerase, chain B, domain 1"/>
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        <property type="entry name" value="Helix hairpin bin"/>
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        <property type="entry name" value="Palm domain of DNA polymerase"/>
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        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
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        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
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        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
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        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
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        <property type="entry name" value="DNA/RNA_pol_sf"/>
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        <property type="entry name" value="DNA_pol_B_thumb"/>
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        <property type="entry name" value="DPOD/Z_N"/>
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        <property type="entry name" value="PolZ_Rev3"/>
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        <property type="entry name" value="REV3_N"/>
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        <property type="entry name" value="RNaseH-like_sf"/>
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        <property type="entry name" value="RNaseH_sf"/>
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        <property type="entry name" value="Znf-C4pol"/>
    </dbReference>
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        <property type="entry name" value="DNA POLYMERASE ZETA CATALYTIC SUBUNIT"/>
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    </dbReference>
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        <property type="entry name" value="DNA POLYMERASE ZETA CATALYTIC SUBUNIT"/>
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    </dbReference>
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        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="POL3_N"/>
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    </dbReference>
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        <property type="entry name" value="REV3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="zf-C4pol"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNAPOLB"/>
    </dbReference>
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        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 20" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="16" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 20" id="KW-0235">DNA replication</keyword>
    <keyword evidence="15 20" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="12 20" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="13 20" id="KW-0408">Iron</keyword>
    <keyword evidence="14 20" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 20" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 20" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="17 20" id="KW-0539">Nucleus</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 20" id="KW-0808">Transferase</keyword>
    <keyword evidence="11 20" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 20" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNA polymerase zeta catalytic subunit N-terminal" evidence="26">
        <location>
            <begin position="8"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="DNA polymerase delta/zeta catalytic subunit N-terminal" evidence="25">
        <location>
            <begin position="54"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B exonuclease" evidence="23">
        <location>
            <begin position="603"/>
            <end position="786"/>
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    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B multifunctional" evidence="22">
        <location>
            <begin position="853"/>
            <end position="1299"/>
        </location>
    </feature>
    <feature type="domain" description="C4-type zinc-finger of DNA polymerase delta" evidence="24">
        <location>
            <begin position="1352"/>
            <end position="1421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="272"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="422"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00066055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU000442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF00136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF14260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF24055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF24065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="PCH36835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="1447" mass="163139" checksum="94B00B356CBF7655" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J5I9</accession>
    <name>A0A2H3J5I9_WOLCO</name>
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        <recommendedName>
            <fullName evidence="2">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_167517</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="entry name" value="FHA_Ki67"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="FHA_dom"/>
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    <dbReference type="InterPro" id="IPR008984">
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        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <begin position="34"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="254"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
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    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="482"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
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    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="1210"/>
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        <location>
            <begin position="311"/>
            <end position="328"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="386"/>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="419"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
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            <taxon>Agaricomycetes</taxon>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
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</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J7Z6</accession>
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            <fullName evidence="6">Spliceosomal protein DIB1</fullName>
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        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
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                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
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                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
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                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Essential role in pre-mRNA splicing. Also essential for entry into mitosis (G2/M progression) as well as for chromosome segregation during mitosis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the DIM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467832">
        <property type="protein sequence ID" value="PCH34849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J7Z6"/>
    <dbReference type="STRING" id="742152.A0A2H3J7Z6"/>
    <dbReference type="OMA" id="GMYELYD"/>
    <dbReference type="OrthoDB" id="147752at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02954">
        <property type="entry name" value="DIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000004">
        <property type="entry name" value="Spliceosomal protein DIB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004123">
        <property type="entry name" value="Dim1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12052:SF5">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12052">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEN 4A, 4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02966">
        <property type="entry name" value="DIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017199">
        <property type="entry name" value="mRNA_splic_U5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01410">
        <property type="entry name" value="DIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4 6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="38"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR017199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR017199-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PCH34849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="142" mass="16694" checksum="5E390C39E9A98E8C" modified="2018-01-31" version="1">MSYFLPHLPSGWHVDEAIKSEEDRVVVIRFGHDWDSQCMTMDETLYSVAEKVQNFAVIYLVDITEVPDFNKMYELYDPCTVMFFYRNKHIMIDLGTGNNNKINWAMDNKQELIDIIETVYRGASKGRGLVVSPKDYSTRYRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J868</accession>
    <name>A0A2H3J868_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">60S ribosome subunit biogenesis protein NIP7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WOLCODRAFT_112632</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Required for proper 27S pre-rRNA processing and 60S ribosome subunit assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Interacts with pre-ribosome complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NIP7 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH33838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J868"/>
    <dbReference type="STRING" id="742152.A0A2H3J868"/>
    <dbReference type="OMA" id="LISMGTC"/>
    <dbReference type="OrthoDB" id="27490at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902626">
        <property type="term" value="P:assembly of large subunit precursor of preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd21146">
        <property type="entry name" value="Nip7_N_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21151">
        <property type="entry name" value="PUA_Nip7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.130.10:FF:000002">
        <property type="entry name" value="60S ribosome subunit biogenesis protein NIP7 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.220:FF:000001">
        <property type="entry name" value="60S ribosome subunit biogenesis protein NIP7 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="entry name" value="PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040598">
        <property type="entry name" value="NIP7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055359">
        <property type="entry name" value="Nip7_N_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016686">
        <property type="entry name" value="Ribosomal_synth_fac_NIP7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005155">
        <property type="entry name" value="UPF0113_PUA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23415">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASES REGULATORY SUBUNIT/60S RIBOSOME SUBUNIT BIOGENESIS PROTEIN NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17833">
        <property type="entry name" value="pre-PUA_NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03657">
        <property type="entry name" value="UPF0113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017190">
        <property type="entry name" value="Rbsml_synth_fac_NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88802">
        <property type="entry name" value="Pre-PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="PUA" evidence="8">
        <location>
            <begin position="95"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00054591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR017190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PCH33838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="180" mass="20503" checksum="0EDCA7EE5DB2E18D" modified="2018-01-31" version="1">MRPLTEEESKAVFTKLANYIGKNLIHLIDRPDEPYCFRLHKDRVFYVSESSMRLGISVARTNLVTLGTCFGKFSKSGKFKLHITALDYLAQYAKYKVWIKPNGEMPFLYGNHVLKAHLGRITEDTPEHQGVVVFSMNDTPLGFGVTARSTVDTRKLDPTAIIVFHQADVGEYLRDEETLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J8V2</accession>
    <name>A0A2H3J8V2_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histone deacetylase</fullName>
            <ecNumber evidence="2">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WOLCODRAFT_66000</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the histone deacetylase family. HD Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="2"/>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH38636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J8V2"/>
    <dbReference type="STRING" id="742152.A0A2H3J8V2"/>
    <dbReference type="OMA" id="GWLRAFH"/>
    <dbReference type="OrthoDB" id="1918432at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034967">
        <property type="term" value="C:Set3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.20:FF:000007">
        <property type="entry name" value="Histone deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003084">
        <property type="entry name" value="HDAC_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF36">
        <property type="entry name" value="HISTONE DEACETYLASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01271">
        <property type="entry name" value="HISDACETLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="10">
        <location>
            <begin position="18"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="390"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="390"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="429"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="439"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="450"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="485"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="495"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="517"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="534"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PCH38636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="544" mass="60312" checksum="D4F136362B89AFBC" modified="2018-01-31" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-09-13" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J9A2</accession>
    <name>A0A2H3J9A2_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_149717</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH38776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J9A2"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH38776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="293" mass="33057" checksum="282A4CD76B2F9273" modified="2018-01-31" version="1">MEIWDEIISYFWDEPETLGTTEEVCRGWFARSRYFKTKALKTGRVLAAKEQVYHCALSIRAVSRNRRVSRNVWIVGAGFSTNKGPRGSVAHFATFAATFAGLEHPGLSELRLMSGEWKTGTIPDSIFRHLSTYASITQLWLDDLTFPSITTFGRLICSLTGLQELSIGDVNITNGQPPSSRRRWNPPPNMRLLFLLEDYRATFSDSLDIFRALVVTKLTMKYEILELMAVPREAVELGFVWQLLRSSRPSLHKLVLDISSLLQIPKDAVLAIIGKSTVDAKSAEPHLNLQNKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J9L1</accession>
    <name>A0A2H3J9L1_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">26S proteasome regulatory subunit 7 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">WOLCODRAFT_88005</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PDK/BCKDK protein kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH38305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J9L1"/>
    <dbReference type="STRING" id="742152.A0A2H3J9L1"/>
    <dbReference type="OMA" id="PEQISTF"/>
    <dbReference type="OrthoDB" id="1937997at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19502">
        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000005">
        <property type="entry name" value="26S protease regulatory subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000440">
        <property type="entry name" value="26S protease regulatory subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000027">
        <property type="entry name" value="26S protease regulatory subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.20">
        <property type="entry name" value="Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036784">
        <property type="entry name" value="AK/P_DHK_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
    <sequence length="852" mass="93440" checksum="6362A44736F2EF63" modified="2018-01-31" version="1"> </sequence>
</entry>
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    <accession>A0A2H3JAH7</accession>
    <name>A0A2H3JAH7_WOLCO</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
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        </lineage>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
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                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
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        </citation>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
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                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
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                <person name="Lundell T."/>
                <person name="Martin R."/>
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                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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    </dbReference>
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        </source>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="283" mass="30823" checksum="E04DD66156206305" modified="2018-01-31" version="1">MAPRVWFITGASSGFGRAMTEAVLRHGDIAVATLRTPEVIADIASQYSSDRLLAVKLDVSKEEDVISAFTQTREAFGRVDVVFNNAGFGVFAEIEATPLDAARAMFEVNFWGAANVSREAVRHFREVNTPQGGILLQVNSMAGYQGVALNGYYCASKFALQGLTEALVTEVDPEWNIKIVSIDSGAFRTNGPNAAIRIPPHPAYNKPNLLSSKYRSWIDDPNLALRGDVNKAVDVIYKVADLDDPPVHFPLGRDSVDVAKKKVESLLADVDKYATWSDGTEAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JAL1</accession>
    <name>A0A2H3JAL1_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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        <lineage>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">MD-104</strain>
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    </evidence>
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    </evidence>
    <sequence length="411" mass="45268" checksum="5FDB765992600FA9" modified="2018-01-31" version="1">MFPSLHTLELHYPTKNSTGAHQMFYMSELCALLSRAPNLSDVSLNVAVPLVDVHVHESPTILDAHSTSSPYHSRRSPHVVKTLVLPRLHRLDWNLAPPKDAWLLFKFIDPRSLRLLEICLNRSGVRWPQLDLDMAPGDIPVVQFSQLEELRLECVDTEGLSTSLKKMNFPALQKLSISFLPPAAVGPKSTHLPRHESIFREPRFPNLTHLSLSRFSLDKDNVKMMLRYLQALTHLTLDSCPGAGPVVCSLSGGACANSHVSSTRTWSCPRLQHLRLVRCPDVRFRCLSGMVHSRKVCSSDDAGGSVVLLGKGRQFDVATSRVVKPLKKTAMSHSGSAPSTPYGKGHNSVMSAAGTSASPNGSLLSEWNPYAILKPSCLVTIYIASCPRISEAEAMSLKSTNWGVSDVTYYQ</sequence>
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                <person name="Barry K."/>
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                <person name="Kumar T.K.A."/>
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                <person name="Ohm R.A."/>
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                <person name="Martin F."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Benoit I."/>
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                <person name="Kallen N."/>
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    </evidence>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
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    <sequence length="467" mass="51805" checksum="F68F3AD49C14020E" modified="2018-01-31" version="1">MSLSARKAPVSRPSLLARFTSYTTAFLDKSEADQASLFPSEERNATPMSGSPTSSVLSLPIAPPQSTPAEISLKRSEDLQRQLDNSNVALKSKTAEATALESRVRELEALLSTSRAETEAAQTALRAQEEARARAEETCSGLRVQLEEARAESTRHSSELTIAHDELAEWRNAEESRAAELDAERASRLRAESELEASREENRQIDAARAEATAEAESSATQLRDASVYIEDLTALCASLKAENATGSARVDELSHAVETEREGRERAESDVKDALGRIESLEAQLEQEKSQLTRVKSEQEDQEVRHREDISAMKTEHERLLQEAVQQTKNDAETKHSEETQFAISRLATAHQATLQKLEQQHRSAFLSTVRSSETRLSERDVQIKSLQEELAQSRADLGAATHQLRIMRVELDAAREREAVTDQQRMIGDVLPKSLVPALATILMSVNASVRVVKQIWERPGPLHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JCH3</accession>
    <name>A0A2H3JCH3_WOLCO</name>
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        <submittedName>
            <fullName evidence="7">EXS-domain-containing protein</fullName>
        </submittedName>
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        <name evidence="7" type="ORF">WOLCODRAFT_125801</name>
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        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="9970435at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004342">
        <property type="entry name" value="EXS_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10783:SF103">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 53 MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10783">
        <property type="entry name" value="XENOTROPIC AND POLYTROPIC RETROVIRUS RECEPTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <location>
            <begin position="130"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="EXS" evidence="6">
        <location>
            <begin position="62"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PCH35378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="283" mass="33800" checksum="DA2D41B6DCB0EAF4" modified="2018-01-31" version="1" fragment="single">MYKPSRYWLVRNLYRQLTSGVRHVEFQDFWMGDQFCSLAFTLADLWFVGCAYSHELRNWRVCTTGPNWGPQFALAALPFFVRFVQSIRRWMDSKLTTHLINAGKYGTGLIYYLTYYLWRQHGGGHGTRFVVWIIIGVLYASYAAAWDILMDWSLMQPHARYRFLRSELIYTSHRPLYYIAMITNIIIRFEFIMYIPEKGINYVIRTFIAAMLEMLRRWQWNFFRLENEHVGNMDQYRVTREVPLPYSFDASHESDGGDEDDDVALRRSMTSASWRRRRMSAQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JCS8</accession>
    <name>A0A2H3JCS8_WOLCO</name>
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        <submittedName>
            <fullName evidence="3">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">WOLCODRAFT_29524</name>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467987">
        <property type="protein sequence ID" value="PCH39385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JCS8"/>
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    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="AKR"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625">
        <property type="entry name" value="AFLATOXIN B1 ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625:SF40">
        <property type="entry name" value="ALDO-KETO REDUCTASE YAKC [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="27"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="110"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH39385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="259" mass="29445" checksum="84B7B3C86C31B127" modified="2018-01-31" version="1">MSSAKYPTRQLGRNGPQVSAIGFGAMDIYGTSEVTIGKWFAQTGRRSDIFLATKFGGCDLTPGAENPLKPNSKPSYIRTRLENSLKNLQTEWIDLYYQHRVDPEVPIEVMEYSLFELEIETTGFVTASRELGASVVAYSHLEEVRVITGRFKLRSDFDPDDFRYYLPRFSDEDFLALVDKFQSVARKYNATPGQIALAWILTTHTDFVPIPGTETADRLEENAKAAEIQLADEDVRELRAAMTLPMFREYGMRRSTWLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JD87</accession>
    <name>A0A2H3JD87_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HIT-like protein</fullName>
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    </protein>
    <gene>
        <name evidence="5" type="ORF">WOLCODRAFT_136701</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
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            <taxon>Fungi</taxon>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
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                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468053">
        <property type="protein sequence ID" value="PCH40166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JD87"/>
    <dbReference type="STRING" id="742152.A0A2H3JD87"/>
    <dbReference type="OMA" id="CAFCRIV"/>
    <dbReference type="OrthoDB" id="672793at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46648:SF1">
        <property type="entry name" value="ADENOSINE 5'-MONOPHOSPHORAMIDASE HNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46648">
        <property type="entry name" value="HIT FAMILY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="4">
        <location>
            <begin position="25"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="2 3">
        <location>
            <begin position="115"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-AMP-histidine intermediate" evidence="1">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PCH40166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="176" mass="19495" checksum="0D34BB8154149087" modified="2018-01-31" version="1">MTSFIIKAHEGRAIPEQWKTEPDCPFCQIIRDDAPAYRLYENDQVIAFLDILPLRPGHILVVPKTHYSRVSELPPEFAAAVGAAVSKVAHALTEALENTALNVVCNQDYAQAVPHVHYHIIPAPTAADIAKSSPSKVDHRVEPLSQKEMHRLEFEARDGLDDGAARILVAKIRAHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JDJ0</accession>
    <name>A0A2H3JDJ0_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Bax inhibitor family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WOLCODRAFT_63835</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH34027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JDJ0"/>
    <dbReference type="STRING" id="742152.A0A2H3JDJ0"/>
    <dbReference type="OMA" id="TLMWSER"/>
    <dbReference type="OrthoDB" id="1277691at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006214">
        <property type="entry name" value="Bax_inhibitor_1-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291">
        <property type="entry name" value="BAX INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291:SF112">
        <property type="entry name" value="GROWTH HORMONE-INDUCIBLE TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01027">
        <property type="entry name" value="Bax1-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="271"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PCH34027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="338" mass="36363" checksum="6D2D97AF74334323" modified="2018-01-31" version="1">MFRVGSLPSLRPVTSPLVARAVQQPHAAALRSFSNARPNVLSALREHSQGIKPFVFTKQSRTFLTDSAPVVARPTQSEAWKRYAITAVSGTVAGTIVVVNAFFNRETRDSLSPVEQSYLHESFMYAGAGLGVTAVVARSLFRSGAAFRIMSANPWVVLGVSLVGSIGTMMGVMYTPPENTILKHTFWLGFNACQAAVLSPLFFLSPAILSRAALYSAGVFGSLSYIGATAANDRYLYMGGPLLAGVTVVALSSLAPMALPLGMRGLQVAEAISLYGGLAVFGGFILFDTQKILQHARMAEMGTGPRDPMREAISLELDMINIFIRIVQILAMQQNRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JDW5</accession>
    <name>A0A2H3JDW5_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_166525</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467865">
        <property type="protein sequence ID" value="PCH35868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JDW5"/>
    <dbReference type="STRING" id="742152.A0A2H3JDW5"/>
    <dbReference type="OrthoDB" id="2804509at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="210"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH35868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="280" mass="30052" checksum="686F230DD9D03F75" modified="2018-01-31" version="1">MSLESLYPIAIPVTDELALSQLETWISAEYGPGYEFDIAYPDQSTSIWEYSAVDHHDYNDLFNQYVNAGAALTNTMHSELDMQHLSQYSALSAVVSLPPLAAAPTPVPTAPPPVAEAYHSSAALQPSSETPLLPSPSAAPVLPQTQNNFQTGVTSSGTFYVGPSGKIEDTNSGAPVYSTTTAQRIAIADKIALLDMPRHKRAFKRSTSVACFFCRKRKIACGGPPEGTVDRTCGWCARRNQKCAYPPSGAKSLRFRPYQSQGSSGSPTVPSASQIKNESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JE77</accession>
    <name>A0A2H3JE77_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">UPF0187-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WOLCODRAFT_109510</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB467909">
        <property type="protein sequence ID" value="PCH37039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="742152.A0A2H3JE77"/>
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    <dbReference type="OrthoDB" id="1368at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044669">
        <property type="entry name" value="YneE/VCCN1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281">
        <property type="entry name" value="UPF0187 PROTEIN YNEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281:SF19">
        <property type="entry name" value="VOLTAGE-DEPENDENT ANION CHANNEL-FORMING PROTEIN YNEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25539">
        <property type="entry name" value="Bestrophin_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="364"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="389"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH37039.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="493" mass="55381" checksum="A1DCB99ACDB507CD" modified="2018-01-31" version="1">MLAIDPFAPTRGGFFSQLINAISATALIRCWPLLVFFSAWSTAICVISHNVYNLGIQSTLLTVIGTVLGFVVSYRTTSSFERYNEGRKLWSQIVLASRTFARTVWFHIPDASPSFADDKSTPEQRRQRVLIEKKTTINLVEAFAVAVKHYLRGEEGVYYVDLYHLVKFLPPYALPASIPSVIDVSDPDSPDANEQVSDMRSLRSVPSPHAASFAKAGQLPMPVTALRRVQVVSPSIDREKVEKDDRTSMVNGFEPDSFLLPARNPPKYHLLDLFPMSIFVRLLTKRGKDIKGKTAAKIRAKLRSKTVSHNLPLEISFYLSSYVAALQSHKIIDPPTTTALMNALNQLVDALTGLERILTTPIPFSYRVHLWTVTILYNLLLPFQTWNYVGWLTIPATCLLSFIFFGFLVAGEEIENPFGYDKNDLNMDHFTHNIIRNELRALTAQPVPDPSVWAFSPHNDQVFSFGAGLKERATPDEWIQRGLPRMQAALAIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JEH3</accession>
    <name>A0A2H3JEH3_WOLCO</name>
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        <recommendedName>
            <fullName evidence="1">CxC2-like cysteine cluster KDZ transposase-associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
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            <taxon>Basidiomycota</taxon>
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            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468053">
        <property type="protein sequence ID" value="PCH40606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OMA" id="CCPVATS"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="entry name" value="KDZ"/>
    </dbReference>
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        <property type="entry name" value="CxC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18758">
        <property type="entry name" value="KDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CxC2-like cysteine cluster KDZ transposase-associated" evidence="1">
        <location>
            <begin position="8"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH40606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="264" mass="30194" checksum="44E489A6AABF4E8F" modified="2018-01-31" version="1" fragment="single">LHGQGIMITVVDVTGVHHLDIIWCCCPVATSHDLQLLESGLYPASILDPMTAFTFRVLDNFLLAKKECKTSAVVYYSKLRRVTKNAFPYTVLDRYHELLRVPRQWRNLNYCKWHGYGHGTRDDVPPGGLAMFCTACMQPGINLPDGWDNNPVRWKYMQMVIMDGNFTAEHLKMRNPEDDVWIVDRHGFMITPQRVFDQPRTPGLSNPLRPVSAQPPFNCHDHWAVNQMNADRSNLESTGIGATACRHHCCFFPHAVVDFQKGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JEH8</accession>
    <name>A0A2H3JEH8_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">WOLCODRAFT_61780</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">MD-104</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 16">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 17">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH34387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JEH8"/>
    <dbReference type="STRING" id="742152.A0A2H3JEH8"/>
    <dbReference type="OMA" id="MNDINHF"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000238">
        <property type="entry name" value="Cytochrome P450 2A6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
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        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
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        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF2">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ALNH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 16 17" id="KW-0349">Heme</keyword>
    <keyword evidence="13 16 17" id="KW-0408">Iron</keyword>
    <keyword evidence="15 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 16 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0492">Microsome</keyword>
    <keyword evidence="14 17" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="12 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="16">
        <location>
            <position position="448"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PCH34387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="517" mass="58917" checksum="8487F6E10A1238FE" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JEU5</accession>
    <name>A0A2H3JEU5_WOLCO</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_155168</name>
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    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467832">
        <property type="protein sequence ID" value="PCH34517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="265"/>
        </location>
    </feature>
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        <location>
            <begin position="15"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH34517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="291" mass="30837" checksum="E5573B48BF708DCD" modified="2018-01-31" version="1">MLAQRGSRPDDKSQRSVQLRAPTQAQLKSPTWGNEEDDGPMAHPTAGAVPAINRATAAPPALTTAPLDWTTPSGTLPRAPSRQGGPTRGGSPLRPRPSSGQRRKHLGSQRNGAHRPPWIKTRKPTGKGPKDIQVQTRTPPDPSGSDKTILVNGRAPAEGHTARATARVEQTQPQATATDPPAYQTQGRAKAHSRQGNPPRTKSNGSADCLNNHTTPSADRAHMPTKQGAQSGKAARQRVGRGADHTNTPLGPATWSHHTPTASHSNRATAALKAYQGTVRTMNGTGTRRDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JF40</accession>
    <name>A0A2H3JF40_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Complex I-B22</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">NADH-ubiquinone oxidoreductase B22 subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">WOLCODRAFT_99359</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Mammalian complex I is composed of 45 different subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I LYR family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH40826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JF40"/>
    <dbReference type="STRING" id="742152.A0A2H3JF40"/>
    <dbReference type="OMA" id="KWERNAP"/>
    <dbReference type="OrthoDB" id="13598at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20263">
        <property type="entry name" value="Complex1_LYR_NDUFB9_LYRM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045292">
        <property type="entry name" value="Complex1_LYR_NDUFB9_LYRM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033034">
        <property type="entry name" value="NDUFB9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12868:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12868">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE B22 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="17">
        <location>
            <begin position="15"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="70"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="101"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PCH40826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="110" mass="12795" checksum="A638C9F295930C07" modified="2018-01-31" version="1">MSAPAAFSSAHRRYVQSLYRRYLNNELDWVMNRDIWRGRAIAIRAEFERNRNVHDPRELAAIFTKAEADLAARQHPDPYRPTSAPDGTKWERNIPPPVEPIVDHEAEGHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JFI0</accession>
    <name>A0A2H3JFI0_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Pre-mRNA-splicing factor SYF2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WOLCODRAFT_134566</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">May be part of a spliceosome complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the SYF2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467931">
        <property type="protein sequence ID" value="PCH37499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JFI0"/>
    <dbReference type="STRING" id="742152.A0A2H3JFI0"/>
    <dbReference type="OMA" id="RRRMHND"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013260">
        <property type="entry name" value="mRNA_splic_SYF2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13264">
        <property type="entry name" value="GCIP-INTERACTING PROTEIN P29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13264:SF5">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR SYF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08231">
        <property type="entry name" value="SYF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0747">Spliceosome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="26"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="90"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="44"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PCH37499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="307" mass="35284" checksum="823D1B12B3CBE553" modified="2018-01-31" version="1">MSDSPSGSGGSTIQKISDAAEEFVENMTGTADVEAEEQTEEQAEADRKMTMEERKAKMEKLRNKLHESHLANRKSVVEESAKAKTTVREAARLERQRKLAETLRLKADAEERGEDVERRKNWEWTIEENDDWEKKKARKARRAEFEFHNDADAARRRYKKDLDHIKPDLVAYNKQKELAMGLAPGTLVMPGTSSSALNVFDPKAGSSMQIAPISEQQRLAAEHLYRDANSLLYADNKPSEEAIDRVVGKINRDIDKKSKFSRKRHNEEEGDITYINERNRVFNKKIARYYDKYTTEIRASFERGTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JFN7</accession>
    <name>A0A2H3JFN7_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_140494</name>
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    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467876">
        <property type="protein sequence ID" value="PCH36508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JFN7"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH36508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="53" mass="6044" checksum="A3F1E58FEBAD2EF0" modified="2018-01-31" version="1">MMHLRSPQPSLSSETPLGAKPIRHTANRRRTHAHAQPTPYVVLYAEVLPPRYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JFT2</accession>
    <name>A0A2H3JFT2_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">RRN7-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WOLCODRAFT_118149</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRN7/TAF1B family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH41046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JFT2"/>
    <dbReference type="STRING" id="742152.A0A2H3JFT2"/>
    <dbReference type="OMA" id="ICRDIWA"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070860">
        <property type="term" value="C:RNA polymerase I core factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001164">
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        <location>
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        </source>
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        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JGW4</accession>
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        <name evidence="5" type="ORF">WOLCODRAFT_24730</name>
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        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
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        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
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                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5 6">MD-104</strain>
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    </dbReference>
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    </dbReference>
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        </location>
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        </source>
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        </source>
    </evidence>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JGZ0</accession>
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        <submittedName>
            <fullName evidence="5">Epl1 protein</fullName>
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    </protein>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
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                <person name="Lundell T."/>
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                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
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                <person name="Sabat G."/>
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            <dbReference type="DOI" id="10.1126/science.1221748"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD-104</strain>
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        </subcellularLocation>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013675627" evidence="4">
        <location>
            <begin position="22"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PCH38039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="142" mass="14707" checksum="93ABEB4E05624E84" modified="2018-01-31" version="1">MKLSTTISAAVALLVAPAVLAQTTVTVSYDQTYDNASGSMDTVSCSDGPNGLDPPYSTFGSLPDFPYIGGAAAVSGWGSAECGTCWQLTYEDWTINVLAIDHTAEGFNIALEAMNALTDNQAEFLGRVNAVATQVDASVCGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JH28</accession>
    <name>A0A2H3JH28_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Tubulin alpha chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">WOLCODRAFT_24772</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 14">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="14">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH41476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JH28"/>
    <dbReference type="STRING" id="742152.A0A2H3JH28"/>
    <dbReference type="OMA" id="EVRCGAY"/>
    <dbReference type="OrthoDB" id="1662883at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02186">
        <property type="entry name" value="alpha_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000005">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000001">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000008">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002452">
        <property type="entry name" value="Alpha_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01162">
        <property type="entry name" value="ALPHATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10 14" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 14" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="15">
        <location>
            <begin position="45"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="16">
        <location>
            <begin position="244"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PCH41476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="444" mass="48618" checksum="51AB7995B8481D78" modified="2018-01-31" version="1">MREVISLHVGQAGVQIGNACWELYTLEHGISPDGRLVNPVPDSDPSPFFSETGSGKYVPRSLYIDLEPGAVDEVKSGPYRSLFHPETMITGKEDAASNYARGHYTIGKEIIDSVMDKIRRLTDNCNGLQGFFVFHSFGGGTGSGFGALLLERLSADYGRKSKLEFCVYPAPQLSSSIVEPYNAVLTTHATLEYSDCSFMVDNEAIYEICKNKLGVARPSFPNLNRVIAQTVSSITVSLRFGGSLNVDLNEFQTNLVPFPRIHFPVTTYAPLISADKATHEANSVAEMTVSCFETGNQLVKCDPKDGKYMACALLYRGDVVPKAAQAAIGNIKTKKTIQFVDWCKTGFKLGICSEPAAYVPGGDMARSTRSLCMLSNTTAIASAWARLDHKFDLLYSKRAFVHWYVGEGMEEGEFSEAREDLAALEKDYEEVGADTPDDDGGVEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JH37</accession>
    <name>A0A2H3JH37_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD(+) diphosphatase</fullName>
            <ecNumber evidence="4">3.6.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WOLCODRAFT_140187</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + beta-nicotinamide D-ribonucleotide + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60876"/>
            <dbReference type="Rhea" id="RHEA-COMP:15698"/>
            <dbReference type="Rhea" id="RHEA-COMP:15719"/>
            <dbReference type="ChEBI" id="CHEBI:14649"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:144029"/>
            <dbReference type="ChEBI" id="CHEBI:144051"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:60877"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Nudix hydrolase family. NudC subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.22" evidence="4"/>
    <dbReference type="EMBL" id="KB467865">
        <property type="protein sequence ID" value="PCH36024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JH37"/>
    <dbReference type="STRING" id="742152.A0A2H3JH37"/>
    <dbReference type="OMA" id="CNTRTTL"/>
    <dbReference type="OrthoDB" id="10249612at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035529">
        <property type="term" value="F:NADH pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019677">
        <property type="term" value="P:NAD+ catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006742">
        <property type="term" value="P:NADP+ catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03429">
        <property type="entry name" value="NUDIX_NADH_pyrophosphatase_Nudt13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050241">
        <property type="entry name" value="NAD-cap_RNA_hydrolase_NudC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015375">
        <property type="entry name" value="NADH_PPase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049734">
        <property type="entry name" value="NudC-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001299">
        <property type="entry name" value="PRK00241.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42904:SF6">
        <property type="entry name" value="NAD-CAPPED RNA HYDROLASE NUDT12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42904">
        <property type="entry name" value="NUDIX HYDROLASE, NUDC SUBFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09296">
        <property type="entry name" value="NUDIX-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="11">
        <location>
            <begin position="253"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="384"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="384"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="394"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PCH36024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="464" mass="49857" checksum="009CAB8702D714CE" modified="2018-01-31" version="1">MAETYVNFLGGSPLNRLSWLRTSQAFLNAIALAPSTRWLLFQNGQPLLVSEPSTRARSLARLSSAGVRPLLGPEPFFAQGQVAGSPAPSDVLILEAARFHGPPVVFLGLHEPHAGMADALPSSDFSAKADAARVVSNLKGTPFFTLDVSGVPPDALDAALRGSDAAARGAELAFSEPRAAMSAFDAFEASVFAEARSMVDWNTRNKFCPACGSPVYSLWAGWKLTCTSLLPWADNGDKQPCATAKGLHNFAHPRTDAVVIMAVVDESGEKLLLGRNKKWPGKFYSALAGFIEPGESFEDAVKREIWEEAGVKVRDVRYHSTQPWPYPANLMVGFYAIADSSQPLRTDLDNELDDAQWFTREQVLAVLNHAEGTNITRSDHRKLAAAQEERDNASQKAPLTASTANALAGDAVTNEEKEAKAAEDTAELPFRLPPLTAIAGVLVSEWAHRRAGPGSDAGQARGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JHQ1</accession>
    <name>A0A2H3JHQ1_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Rdx family-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_131899</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH41411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JHQ1"/>
    <dbReference type="OMA" id="EYCTQCR"/>
    <dbReference type="OrthoDB" id="60822at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011893">
        <property type="entry name" value="Selenoprotein_Rdx-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02174">
        <property type="entry name" value="CXXU_selWTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36417">
        <property type="entry name" value="SELENOPROTEIN DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G05220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36417:SF2">
        <property type="entry name" value="SELENOPROTEIN DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G05220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10262">
        <property type="entry name" value="Rdx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH41411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="145" mass="16399" checksum="C590D3C254FD7CCB" modified="2018-01-31" version="1">MSEQEKCVDCAPEQQQLAQRSADVKAQDPLDASTFVPPAPLPSPSIAVEFCDRCRWLHRATWVSTELFLTFPAPVLKSITILPLNSEETRGRFRVWLFLDGQPPILVWDRKIEGGFPELKVLKQRIRDRVQPGKSLGHSDHKPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JHV7</accession>
    <name>A0A2H3JHV7_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PPPDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_156986</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467876">
        <property type="protein sequence ID" value="PCH36274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JHV7"/>
    <dbReference type="OMA" id="ICIRTRI"/>
    <dbReference type="OrthoDB" id="37659at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046670">
        <property type="entry name" value="DUF6540"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20174">
        <property type="entry name" value="DUF6540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH36274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="152" mass="17257" checksum="D2DB99AF3ED2622B" modified="2018-01-31" version="1">MSRAYHVYVAQYERCVSPHHWEICIRTRIETNAAGKMTESYGSIFHVQGHTNAWGFQRLDNVHWSNDSYRGKLQIGFAKANEIDAMEKVMRAVPCPNAENANDSWNCQNWVFEAIGDLQRAGFEIKCPPSFTALVNEMENARVAWDAGATSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JHW0</accession>
    <name>A0A2H3JHW0_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_110773</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
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                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
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                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
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            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
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    </evidence>
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            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
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                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
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                <person name="Lindquist E."/>
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                <person name="Nagy L.G."/>
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                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
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                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1221748"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
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        <property type="protein sequence ID" value="PCH39693.1"/>
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            <begin position="306"/>
            <end position="325"/>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="494" mass="54121" checksum="8E3CAB3D96949C4B" modified="2018-01-31" version="1">MEVRRIRKSFPAPSAGVKSFSGVQMVVNDNADNFHAGRPASNHGPPVALFDPTLGLLAYYLSHLDDDIPEIEPNHLQIGAVHMFMEQALRSYENEGKRLTAIEKSLQQAIGIDMTWKQSICGIIPDAVFGGGLPYGVMEVKNEAGLEGDASLQAGLSYAKIVMNGQDKLEALRQRSNYPAVLIGTMGDLLEIGIAVFTDGPYSDCVFSQRLRLDFYQSEDVLRVSRAFKAVQLALTSLHKLYARLQDKPPPKNNIAHIFPSPSPVPSYKGNMPSLSFTDRLSRTGELYLLAKSPDERRSGLYLATMPKSRGADGPATGSSSGDAPDGQVEVVVKFTTKYNADAHRVLADAGLAPALHACIPVCGCLHMVVMERVHGEMAWDVQQRGELLPYTVYKDVKAAINLLHQHNFVFGDLRTPNIMCAPGASSSGSDEGSHAMLIDFDWVGTHGSARYPAILNDTLSVWAFGMQRRAMMYKEHDLAMLEKFRELCQAHTA</sequence>
</entry>
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        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Phaeolaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
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                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
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                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
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                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
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                <person name="Martin F."/>
                <person name="Cullen D."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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    </dbReference>
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            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
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            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH42032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="258" mass="27259" checksum="22685975941892F2" modified="2018-01-31" version="1">MDIAECSREREERQAPAGDGVRPSQAATPTVPTIVMHPSEAPEARGRPISRFGRVFSRRSHSNGDSDTMLNTASISSSLAVDNASSSWRSSSALTSRFHRDKGSKSPTPSDVSSAFSAKAKTKVFSDQNLDVALTIARDVAKGLGACASLIPSAPGLDIVMKGLERVLDGVVEARGNTKEVKEVAESIKQLVDAVKSAYELVSGRKLHVESVPASENMSTEGLSTGPAETLTTVEATRTSEASYDTNALQQAISQLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JIP5</accession>
    <name>A0A2H3JIP5_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Pkinase-domain-containing protein</fullName>
        </submittedName>
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    <gene>
        <name evidence="8" type="ORF">WOLCODRAFT_140114</name>
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    <organism evidence="8 9">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CHEK2 subfamily.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FHA_dom"/>
    </dbReference>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FHA" evidence="6">
        <location>
            <begin position="85"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="193"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="470"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="598"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PCH35867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="653" mass="73261" checksum="E08B081006A41C80" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JJ63</accession>
    <name>A0A2H3JJ63_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_72062</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
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                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="PCH41901.1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="AAA+_ATPase"/>
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    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF17">
        <property type="entry name" value="FUNGAL STAND N-TERMINAL GOODBYE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NPHP3_N"/>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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        <location>
            <begin position="194"/>
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        <location>
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        </source>
    </evidence>
    <sequence length="691" mass="78100" checksum="EB25B7C71A5BFCF5" modified="2018-01-31" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
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        <lineage>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
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                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
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                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
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                <person name="Stenlid J."/>
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                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
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                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
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</entry>
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    <accession>A0A2H3JJU1</accession>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <location>
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            <end position="138"/>
        </location>
    </feature>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH36277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="138" mass="15536" checksum="7081285123911897" modified="2018-01-31" version="1">MAKIPRNFRLLEELEKGEKGIGDGSCSYGLEDGDDIMMTHWNGTIIGPGHTVHENRIYSLKITCGDNYPEQPPTVQFVSRVNLPFVNQVDGKVDASKLPVLAHWNRNNSLETLLVEIRREMASFNNRKLPQPPEGSTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
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    <name>A0A2H3JKQ6_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    <organism evidence="2 3">
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        <lineage>
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                <person name="Riley R."/>
                <person name="Barry K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JLR0"/>
    <dbReference type="OMA" id="IERRIYW"/>
    <dbReference type="OrthoDB" id="3185196at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH40793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="82" mass="9526" checksum="F6CAB789F98A9D86" modified="2018-01-31" version="1">MSSDEIIPGDIVTIQNGVNARREGMVVGTHIDYAGRQIVEVQLEPGEIYQAWYPTVTRVKRTISYTRPKPVDRRSVERYIYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JLX6</accession>
    <name>A0A2H3JLX6_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WOLCODRAFT_131016</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH38728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JLX6"/>
    <dbReference type="STRING" id="742152.A0A2H3JLX6"/>
    <dbReference type="OMA" id="WAITASF"/>
    <dbReference type="OrthoDB" id="4540492at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015149">
        <property type="term" value="F:hexose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045263">
        <property type="entry name" value="GLUT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503:SF8">
        <property type="entry name" value="FACILITATED GLUCOSE TRANSPORTER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="317"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="373"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="409"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="447"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="17"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="235"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PCH38728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="468" mass="49408" checksum="7F4E8089C4CFB1F4" modified="2018-01-31" version="1">MASVHEPQAFTVYGWIACAWILVVSFQYGYHISSLNQIQAVLTCRAAVPSADYGLPTCIPMSDATFSLVTSVYTVGGLIGSLGANVVMDRWGRKGASSASAVSTAVGAALMGISAGLFPLAFGRMLTGVGAGIGLCVGPIFISEIAPPRQRGAIGVLTQFAIVIGIMTTQAIGLQLATPTQWRYVLFFSAILSGAQLLTSPMMIESPTWLSRRGLLADKDATAHRIWQTAQIMHSPDLPNSESADPLLGTGDDEDDENAKADDEHDAAISVPKLLVASELRRPLAIVCFSMLVQQLSGINAVLYYSNDILSKALPDLGPYISLGITIVNVIMTATPIVLIDRLGRKQLLSMSAGGALVSLLGVGVGLNSGMVALASITIVTFVASFAIGIGPVPFVMIPEVSPHHAVSALSSVGLSLNWIANFLVGLVFLPLRNFLSDGDPDKEGRVFYVFAALLAFCTFVLFKVYRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JM51</accession>
    <name>A0A2H3JM51_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_18049</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468135">
        <property type="protein sequence ID" value="PCH42951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JM51"/>
    <dbReference type="STRING" id="742152.A0A2H3JM51"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH42951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="286" mass="31870" checksum="E30F0ECBF636A9D6" modified="2018-01-31" version="1">MTMTARIPINNNSRRRRQGPWATKALICTCDVARAGPPGLHASAGALAGTRRITYILGSRAPYSHGHNHPGSSAPHGAGLGRLLRPKGVRAPHRMTARVCTPVAGRRAPRRSRRRRRALRAQVVRTCLVARALAGACGWRRTCAHAQADLTGEESVIEMYNHTSTEFGPVQVLMVPVAHMSLEQWNMTMNTNLTSSFLVASKYLRRLKEASDSAKSKADDVWPYTIPEEQYSDALIALRPRLRNSIIEKRMIDNGKGPTRTSMLSHVVGDRERMYRMLATYMHLRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JMI1</accession>
    <name>A0A2H3JMI1_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_135875</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="PCH37844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="742152.A0A2H3JMI1"/>
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    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="311"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="347"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="491"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="530"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="396"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="439"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH37844.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JMV9</accession>
    <name>A0A2H3JMV9_WOLCO</name>
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        <submittedName>
            <fullName evidence="7">Acetyl-CoA synthetase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WOLCODRAFT_25795</name>
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        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Phaeolaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
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                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD-104</strain>
        </source>
    </reference>
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        <reaction evidence="5">
            <text>a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate</text>
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            <dbReference type="ChEBI" id="CHEBI:57560"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="742152.A0A2H3JMV9"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035336">
        <property type="term" value="P:long-chain fatty-acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ACYL-COA SYNTHETASE LONG-CHAIN, ISOFORM J"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
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            <end position="508"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="PCH43221.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
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        <recommendedName>
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    </protein>
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            <taxon>Agaricomycetes</taxon>
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    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="742152.A0A2H3JN03"/>
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    <dbReference type="OrthoDB" id="5599552at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Velvet_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038491">
        <property type="entry name" value="Velvet_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572">
        <property type="entry name" value="SPORE DEVELOPMENT REGULATOR VOSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572:SF3">
        <property type="entry name" value="VELVET COMPLEX SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11754">
        <property type="entry name" value="Velvet"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51821">
        <property type="entry name" value="VELVET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Velvet" evidence="6">
        <location>
            <begin position="14"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="86"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PCH37387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="291" mass="32173" checksum="10848B5BB4C36657" modified="2018-01-31" version="1" fragment="single">IGGPVTFHTGKYAGRTLRAELEELQKADLGRKYGRKDRRPLDPPPVVQFRLFEVLDAGTPRQREREFDCYDELDSFGVVCHVDLYPVPDEEDDTEPGGGTRPPSPAFAIPPQQQHPYSRAQPAPYPPAPPYATPPLHVPPRPSPYSSPTYSPRSPPPPPRALAADPDAIAHLDGFAIRESTKCTGALAGATFVQSVVLDHKGRRALMFVFSDLAVKLEGSFVLRYRVFDLFSKANGGPGAPVLAECFGGPFKIYSTKEFPGLRASTDLTKHLSLYGVRLNLRENERKRRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JND8</accession>
    <name>A0A2H3JND8_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Rds1 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_75866</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468146">
        <property type="protein sequence ID" value="PCH43411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JND8"/>
    <dbReference type="STRING" id="742152.A0A2H3JND8"/>
    <dbReference type="OMA" id="TEPRYMV"/>
    <dbReference type="OrthoDB" id="2098436at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039254">
        <property type="entry name" value="Rds1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38705">
        <property type="entry name" value="PROTEIN RDS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38705:SF1">
        <property type="entry name" value="PROTEIN RDS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13668">
        <property type="entry name" value="Ferritin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013608234" description="Rds1 protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH43411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="357" mass="39245" checksum="36307C9433E4CB64" modified="2018-01-31" version="1">MRPLLIPLIAGVCAELALALPYTPVGGLDTNSSSPVYQPLSDFDYQSLNLALYQELIELDLFHNGLAKFSVQDFEDAGLTAEDRYLIEFMADQEVGHATMVSNLLGPNNASKSCEYSYPFETVREFIEFNEMVTRFGESGTYGFLEHLNSRAAAQLLLQSITTEARQQMIFRQFEGIFPMPMWFVPAVTQSMQWTLMAPYIVSCPAENNRVQFQNFPALNITNNPNVTEMSGFAEPAITRNHSAFSAPGDTLYLSWESPGKSVGPNNSYITNTTAGSPQFVAWISQLNTTYTPLTNVSGNSGQTTQPGGEIYGNHTFSTYNGTLFVLVTDSDLPVTPANISLMNQHVVAGPALYQSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JNM2</accession>
    <name>A0A2H3JNM2_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Ubiquitin-conjugating enzyme E2 2</fullName>
            <ecNumber evidence="3">2.3.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">E2 ubiquitin-conjugating enzyme 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">WOLCODRAFT_29215</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="19">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="3"/>
    <dbReference type="EMBL" id="KB467931">
        <property type="protein sequence ID" value="PCH37607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JNM2"/>
    <dbReference type="STRING" id="742152.A0A2H3JNM2"/>
    <dbReference type="OMA" id="DHKSQYI"/>
    <dbReference type="OrthoDB" id="9984419at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23790">
        <property type="entry name" value="UBCc_UBE2A_2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000007">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0749">Sporulation</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 19" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="20">
        <location>
            <begin position="4"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="18">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00039884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00042179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="PCH37607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="166" mass="18681" checksum="AAD52B281247C61E" modified="2018-01-31" version="1">MSTNCRRRLIRDFKRLSTDPPGGISGSPCPDNIMLWNAVIFGPADTPFEDGTFKLVLTFDESYPNKPPTVKFLSRMFHPNVYANGELCLDILQNRWSPTYDVAAILTSIQSLLHDPNPNSPANAEAAQLYRENMKEYVRRVRATVEESWLDPDEQMEESSAAAAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JNP6</accession>
    <name>A0A2H3JNP6_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WOLCODRAFT_136864</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468053">
        <property type="protein sequence ID" value="PCH40419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JNP6"/>
    <dbReference type="OMA" id="NINYCSE"/>
    <dbReference type="OrthoDB" id="2803882at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="207"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="3">
        <location>
            <begin position="19"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PCH40419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="305" mass="33597" checksum="3ECD96BAD5A91901" modified="2018-01-31" version="1">MSSSSGSTPNATGFVVNACSLVSSVLIFYDHLLTMSREVDYIWRAKMTMSTIVFYGSRYAALTYGVFGISQIFSWNNYASCVAMNLIPQILMMVLLLMWTTFSAIRAYAISGHNPYATVCVGLLALVSLSCIMYIVANLRFSRAPSSTGSCSTFFSFTQHLMNKVSTAARVCLIASETTVLIILIICTPDTDITKASFAASMRRNGLVYFAVMVLLNILDAVLFVKGVFYNVFPSFISPLSSIIISRFVLDLREEFDQSSDETLLPSMQFMTNLHAPDSTVETDPYLSASGGQSSSTYEMKDITY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JP77</accession>
    <name>A0A2H3JP77_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_122435</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468146">
        <property type="protein sequence ID" value="PCH43691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JP77"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH43691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="112" mass="13045" checksum="BEEAA161097ED5E1" modified="2018-01-31" version="1">MILFGRTRGRLGPGASLRLRWLTLRLRGGRARWWKRDCSGFGLWTRWQRHFCRVDLFPRGGGSKTRLRCCLAGCNIRCCRPPRAGCFSALLHIPSFCWPLLFRMYLARGFTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JPF1</accession>
    <name>A0A2H3JPF1_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">S-methyl-5'-thioadenosine phosphorylase</fullName>
            <ecNumber evidence="4">2.4.2.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">5'-methylthioadenosine phosphorylase</fullName>
            <shortName evidence="4">MTA phosphorylase</shortName>
            <shortName evidence="4">MTAP</shortName>
            <shortName evidence="4">MTAPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WOLCODRAFT_137585</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>S-methyl-5'-thioadenosine + phosphate = 5-(methylsulfanyl)-alpha-D-ribose 1-phosphate + adenine</text>
            <dbReference type="Rhea" id="RHEA:11852"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58533"/>
            <dbReference type="EC" id="2.4.2.28"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (phosphorylase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.28" evidence="4"/>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH41783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JPF1"/>
    <dbReference type="STRING" id="742152.A0A2H3JPF1"/>
    <dbReference type="OMA" id="ADPFCPE"/>
    <dbReference type="OrthoDB" id="431409at2759"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00873"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017061">
        <property type="term" value="F:S-methyl-5-thioadenosine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09010">
        <property type="entry name" value="MTAP_SsMTAPII_like_MTIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1580:FF:000008">
        <property type="entry name" value="S-methyl-5'-thioadenosine phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01963">
        <property type="entry name" value="MTAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010044">
        <property type="entry name" value="MTAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
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    </dbReference>
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            <begin position="11"/>
            <end position="261"/>
        </location>
    </feature>
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            <position position="17"/>
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        <ligand>
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            <begin position="60"/>
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            <end position="94"/>
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    </evidence>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
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                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
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                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
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                <person name="Kersten P."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Benoit I."/>
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                <person name="Kallen N."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="32"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH44256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Sabat G."/>
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                <person name="Wiebenga A."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468168">
        <property type="protein sequence ID" value="PCH44970.1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02181">
        <property type="entry name" value="GH16_fungal_Lam16A_glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF24">
        <property type="entry name" value="GLYCOSIDASE C21B10.07-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26113">
        <property type="entry name" value="GH16_XgeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013648745" evidence="1">
        <location>
            <begin position="22"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="2">
        <location>
            <begin position="26"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH44970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="379" mass="40993" checksum="8CE0B1B70EEFA648" modified="2018-01-31" version="1">MIFAQILVFVTLLFSATIAACYEPLHDYSGDTFMDGWDFYGKWDNLTLGNVTYLTAEAAAEQKLVYVNDAGNVILRVDNFTDVKDGGLRNSIRLTSSELYDFGSLWIIDAYHLPYGCSVWPAFWSFGPHWPYDGEIDIIEAINTMPNNQMALHTTEGCYHDTPPDQTGFSIDNDCGTASGCTVGESAPNSYESGFAAAGGGVFATQFDVTGIYIWFWSRPNVPASITNATANSSIDISSWGPPSASYPNGTSCDISKYYTAQQLVFDITLCGDWAGVPGIYDSTCYNAGPTHDCYLDNVVGNGSNYDEAYFEVAYVRTYTTGVAVPSSTSAAATAVQTHQATQTQTQAQKSDARSARMGLRGSTFFSILAALLAATVLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JS85</accession>
    <name>A0A2H3JS85_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">ATP-citrate synthase</fullName>
            <ecNumber evidence="23">2.3.3.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="23">ATP-citrate (pro-S-)-lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="23">Citrate cleavage enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="29" type="ORF">WOLCODRAFT_91102</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="29 30" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="29 30">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="22">Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate in multiple biochemical reactions in protein, carbohydrate and lipid metabolism.</text>
    </comment>
    <comment type="function">
        <text evidence="19">Catalyzes the formation of cytosolic acetyl-CoA, which is mainly used for the biosynthesis of fatty acids and sterols.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>oxaloacetate + acetyl-CoA + ADP + phosphate = citrate + ATP + CoA</text>
            <dbReference type="Rhea" id="RHEA:21160"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.3.3.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="21">Composed of two subunits.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 23">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="20">Belongs to the succinate/malate CoA ligase alpha subunit family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 23">In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 23">In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.8" evidence="23"/>
    <dbReference type="EMBL" id="KB468168">
        <property type="protein sequence ID" value="PCH45006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JS85"/>
    <dbReference type="STRING" id="742152.A0A2H3JS85"/>
    <dbReference type="OMA" id="MDYAWAK"/>
    <dbReference type="OrthoDB" id="3261737at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003878">
        <property type="term" value="F:ATP citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006085">
        <property type="term" value="P:acetyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006101">
        <property type="term" value="P:citrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06100">
        <property type="entry name" value="CCL_ACL-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000003">
        <property type="entry name" value="ATP-citrate synthase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000004">
        <property type="entry name" value="ATP-citrate synthase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.230.10:FF:000005">
        <property type="entry name" value="ATP-citrate synthase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.110:FF:000003">
        <property type="entry name" value="ATP-citrate synthase subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000024">
        <property type="entry name" value="Probable ATP-citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="entry name" value="Citrate Synthase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="entry name" value="Cytochrome P450-Terp, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014608">
        <property type="entry name" value="ATP-citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017440">
        <property type="entry name" value="Cit_synth/succinyl-CoA_lig_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032263">
        <property type="entry name" value="Citrate-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056749">
        <property type="entry name" value="Citrate_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033847">
        <property type="entry name" value="Citrt_syn/SCS-alpha_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="SUCC_ACL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23118">
        <property type="entry name" value="ATP-CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23118:SF42">
        <property type="entry name" value="ATP-CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16114">
        <property type="entry name" value="Citrate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24948">
        <property type="entry name" value="Citrate_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036511">
        <property type="entry name" value="ATP_citrt_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01216">
        <property type="entry name" value="SUCCINYL_COA_LIG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00399">
        <property type="entry name" value="SUCCINYL_COA_LIG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0007">Acetylation</keyword>
    <keyword evidence="13 23" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 23" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8 23" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="17 23" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14 23" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 23" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 23" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 23" id="KW-0808">Transferase</keyword>
    <keyword evidence="15" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="ATP-citrate synthase ATP-grasp" evidence="28">
        <location>
            <begin position="2"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-citrate synthase citrate-binding" evidence="27">
        <location>
            <begin position="293"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="CoA-binding" evidence="26">
        <location>
            <begin position="540"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-citrate synthase/succinyl-CoA ligase C-terminal" evidence="25">
        <location>
            <begin position="705"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="24">
        <location>
            <position position="805"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00054002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00060724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00062455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00093367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PIRNR" id="PIRNR036511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Glotzer D."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD-104</strain>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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</entry>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
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                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
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                <person name="Morin E."/>
                <person name="Murat C."/>
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                <person name="Ohm R.A."/>
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                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">MD-104</strain>
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            <dbReference type="EMBL" id="PCH40347.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
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</entry>
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    <accession>A0A2H3JW48</accession>
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            <fullName evidence="14">Chromatin modification-related protein</fullName>
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        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
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    </organism>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
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                <person name="Larrondo L.F."/>
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                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
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                <person name="Ohm R.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">MD-104</strain>
        </source>
    </reference>
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        <text evidence="14">Component of an histone acetyltransferase complex.</text>
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        <text evidence="14">Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.</text>
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        <subcellularLocation>
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        <text evidence="14">The PHD-type zinc finger mediates the binding to H3K4me3.</text>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
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        <property type="entry name" value="ING_fam"/>
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        <property type="entry name" value="ING_N_histone-binding"/>
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        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
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        <property type="entry name" value="Znf_FYVE_PHD"/>
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        <property type="entry name" value="Znf_PHD"/>
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        <property type="entry name" value="Znf_PHD-finger"/>
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        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
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    </dbReference>
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        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12998">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ZF_PHD_2"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="10 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6 12 14" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 13 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="16">
        <location>
            <begin position="256"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="162"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="162"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="231"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="261"/>
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        <ligand>
            <name>Zn(2+)</name>
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        </ligand>
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    <feature type="binding site" evidence="12">
        <location>
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        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="11">
        <location>
            <position position="258"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="11">
        <location>
            <position position="269"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="11">
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            <position position="273"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="11">
        <location>
            <position position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010210"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022604"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-50"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR628651-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH40944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="323" mass="34801" checksum="070055DAA90F131D" modified="2018-01-31" version="1">MSQANLEEAATIAAEYVSSLDNLPGETQFLLDEIRHREQRAHELQQEIQRESSKYIRHSLKSAPGQALSARDAAIPDSVAGYYTEMDQLAAEKVALAERMVQLVARARARLNHDLDRVLALQGEADPALQGGLFAPSARAAASVVDRVNESLRSAIAIPEAVPAPPAAPPQPPTKKRRTMGAASAGSIKLPSPAPMTAGAYGAQRSRLGQQVSVRPSPLRSRRATASSGADPDEDAEGEDDVDDALEEGGDAEDKELYCFCQKLSYGEMIACDNPNCRYQWFHLPCVNLKPPLPENWFCEDCVANMKKGVAGGVGAGRKGRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JYS8</accession>
    <name>A0A2H3JYS8_WOLCO</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">WOLCODRAFT_153090</name>
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    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="134" mass="15847" checksum="AE56C40B282B91A8" modified="2018-01-31" version="1">MAAVAQQMQSTWEKKRKEKETKYFQEMKASLDHCVSSDRILTRTTEFREAGDEMNALYEKFVMDCATVEDEIRKLWEQLLSEQRKLLTLAEQKHKRVMESENERERGQVQGMAIAKRAIEDFNKLVTSLREIDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JZ69</accession>
    <name>A0A2H3JZ69_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pentacotripeptide-repeat region of PRORP domain-containing protein</fullName>
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    <gene>
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    <organism evidence="6 7">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Phaeolaceae</taxon>
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        </lineage>
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    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Regulates mitochondrial small subunit maturation by controlling 15S rRNA 5'-end processing. Localizes to the 5' precursor of the 15S rRNA in a position that is subsequently occupied by mS47 in the mature yeast mtSSU. Uses structure and sequence-specific RNA recognition, binding to a single-stranded region of the precursor and specifically recognizing bases -6 to -1. The exchange of Ccm1 for mS47 is coupled to the irreversible removal of precursor rRNA that is accompanied by conformational changes of the mitoribosomal proteins uS5m and mS26. These conformational changes signal completion of 5'-end rRNA processing through protection of the mature 5'-end of the 15S rRNA and stabilization of mS47. The removal of the 5' precursor together with the dissociation of Ccm1 may be catalyzed by the 5'-3' exoribonuclease Pet127. Involved in the specific removal of group I introns in mitochondrial encoded transcripts.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Binds to mitochondrial small subunit 15S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCM1 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="742152.A0A2H3JZ69"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47936">
        <property type="entry name" value="PPR_LONG DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
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        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="469"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="477"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006192"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PCH43178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="805" mass="89170" checksum="4B87CEC403EF91C2" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K0X1</accession>
    <name>A0A2H3K0X1_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_139276</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468168">
        <property type="protein sequence ID" value="PCH44829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K0X1"/>
    <dbReference type="STRING" id="742152.A0A2H3K0X1"/>
    <dbReference type="OMA" id="KTHREAW"/>
    <dbReference type="OrthoDB" id="3256413at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
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                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
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                <person name="Kuo A."/>
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            <dbReference type="DOI" id="10.1126/science.1221748"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">MD-104</strain>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Barry K."/>
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                <person name="Martinez A.T."/>
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                <person name="Benoit I."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </feature>
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        </location>
    </feature>
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    </evidence>
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    </evidence>
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    </evidence>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH44898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="377" mass="43874" checksum="034C398232C2230A" modified="2018-01-31" version="1">MPAAWEDFDPKWKSKVKEPDVFDNDKIKLKDWWIDMEQYISSNKQLLMTSSQKVEMAFSYICGIKVKSWKESFYRKYYNRNQLWWSISWERFQWELFNKFDDPDRKKKVFRAMQVLSMKLGQSTDYFTDLETLCEEAEFDMDNSYILELIEKNVPRDVFLPTYMSFAQAKDENGQPRPIPTDYPTWKNSIEHTDHYLFRINESMKSHQNTSNKPTQRRPTTNNVNNANTATPQQRMARMEIPCRNCGNKKKDWADRSKCTSPTWHTPDWKQSKGLPTYTSREVPNTNQRTRAATEIPTASTSGITEIPPSSQEQMREMKILKPSTQIEDVNDVDDSAGNVMEIDHVPSGSTMDYMGSLPAPDIDDEDWVLAGGLAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K4R1</accession>
    <name>A0A2H3K4R1_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_138756</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468157">
        <property type="protein sequence ID" value="PCH44044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K4R1"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH44044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="177" mass="20202" checksum="A6ED693586384B91" modified="2018-01-31" version="1">MTIPPVRIDHDGHDLSAEVQQLLWHAGASLQHLSFGLCLPTSGKGFHSYAPDYGCLDFSDNVALETVEVTVIVTEKQINSSSIDWIPRFLFQSRSVPSLKWVTWRFERLNSSLRATDVLPMLESCSQLDEILDDRQPSLRLEFDMHADETGDADDILEEHASTYFPRLAERLTRYYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K5L1</accession>
    <name>A0A2H3K5L1_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_26704</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468157">
        <property type="protein sequence ID" value="PCH44344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K5L1"/>
    <dbReference type="STRING" id="742152.A0A2H3K5L1"/>
    <dbReference type="OMA" id="DFYERWR"/>
    <dbReference type="OrthoDB" id="2788977at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH44344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="220" mass="23933" checksum="4190A80B554D07BC" modified="2018-01-31" version="1" fragment="single">MSDSADASPAPAPAPALGGSPALQEVHSEQPCPSNGREPGDFDAVLAAASSRSLRYEHQIKDLEARLTVDMSNSRAIHNLLQEVLVGLHQSRQRAGAALNATVPHITQNLDDDIGVLDLLREELPLVGQQVRDIRNVYDSGRDKARDLTAALEWLNTPLSARLRTIIFTPHAPVSARAAALIRALFGVALLVCVWIAWITLQGAVRAHRQRLVWGERLMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K7H3</accession>
    <name>A0A2H3K7H3_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Programmed cell death protein 2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_123482</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468157">
        <property type="protein sequence ID" value="PCH44397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K7H3"/>
    <dbReference type="STRING" id="742152.A0A2H3K7H3"/>
    <dbReference type="OMA" id="HQVIRYS"/>
    <dbReference type="OrthoDB" id="443682at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007320">
        <property type="entry name" value="PDCD2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47524">
        <property type="entry name" value="20S RRNA ACCUMULATION PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47524:SF1">
        <property type="entry name" value="20S RRNA ACCUMULATION PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04194">
        <property type="entry name" value="PDCD2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Programmed cell death protein 2 C-terminal" evidence="2">
        <location>
            <begin position="291"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH44397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="453" mass="50259" checksum="2A13D57782E1686A" modified="2018-01-31" version="1">MAPQNEDDWSDSDDEVGSDVETAVQLGIPDGRIDAPADLLDATVSRIGGHPAFLRAPPPLESATCKNCHQPMQLLVQVWCPLENSPNDRAIYVWGCARGACQKKEGSVCAWRGLRYNQKYAEKLARRREKEKAQEEEKARAAEEEAARQSAPKTNPFSMKAMPAAASNPFALGDQIFGAAPLAPVQPQDSAKHQDELEASSDGDRDDDSSEDEGANELADRLASATLDDSLEWSKAPAYDPMYLSTVAEYLPPARKMKIPAGAEIVEDDEDKKGKDGGWTLEGYENSIEVDHVFERFTKRVGYEGEQCLRYELGGTPLPFARDSIFDKLFPTPPAPPLPVTKADFMVTPPQRRTYDPSSLPPCPHCRAPRVFECQLMPNLINVLRAPAEGPRKPLSDEERRQEVMRALRGERAAERVGMEWGTCMVFSCEKDCADPDTRGGWHEELVLVQWDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K7L7</accession>
    <name>A0A2H3K7L7_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_165139</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
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                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
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                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH34410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="99" mass="10772" checksum="E554BEACA2CD07AA" modified="2018-01-31" version="1">MAIEKYDAPESIETRDTVNLARRTVVGTITTSRHRSSFPPGILKDVANVKDVITPKLIETGLKQGKIVDFLIELEVVVQAGAAGEERAGLIASRRPCRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IYJ3</accession>
    <name>A0A2H3IYJ3_WOLCO</name>
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        <recommendedName>
            <fullName evidence="8">Transcription elongation factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WOLCODRAFT_106602</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the TFS-II family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OMA" id="RFVVMTH"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031440">
        <property type="term" value="P:regulation of mRNA 3'-end processing"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="TF_IIS-typ"/>
    </dbReference>
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        <property type="entry name" value="TFIIS/CRSP70_N_sub"/>
    </dbReference>
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        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003618">
        <property type="entry name" value="TFIIS_cen_dom"/>
    </dbReference>
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        <property type="entry name" value="TFIIS_cen_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="TFSII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11477:SF0">
        <property type="entry name" value="IP08861P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11477">
        <property type="entry name" value="TRANSCRIPTION FACTOR S-II ZINC FINGER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08711">
        <property type="entry name" value="Med26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07500">
        <property type="entry name" value="TFIIS_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TF_IIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00510">
        <property type="entry name" value="TFS2M"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47676">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Elongation factor TFIIS domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00466">
        <property type="entry name" value="ZF_TFIIS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 8" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS N-terminal" evidence="11">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIS central" evidence="12">
        <location>
            <begin position="144"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIS-type" evidence="10">
        <location>
            <begin position="261"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="74"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="93"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="127"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00649"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU368078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
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            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS51319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PCH34811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="303" mass="32813" checksum="4D1456A3A55A48EE" modified="2018-01-31" version="1">MSAAELKSLVKSLHGASTDEDTIAVLKQLQQQNKITEAILRESKAGLAVGKLRSHATKDVAELAKAIVKKWKQDVDREKHPNGKLSAAGRKNSVASSTGTPSTPVSMTPTSSSNNGSGNNAGNSAGVRSTTADGVSTAVTGDKTRDKCIELLYNALASDSGAPSELIMSRAKAIENIVRQDNGGTTAAYKSKIRSFFVNLKDKNNPGLRESVVSGDLPIQRFCRMTSQEMASEERKAADRQIMEENLFKALGAEEVQAETDAFQCGRCKQRKCRYRQAQTRSADEPMTTFVTCTVCNNRWKFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IYK5</accession>
    <name>A0A2H3IYK5_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein-L-isoaspartate O-methyltransferase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WOLCODRAFT_139718</name>
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    <organism evidence="11 12">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
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            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Initiates the repair of damaged proteins by catalyzing methyl esterification of L-isoaspartyl and D-aspartyl residues produced by spontaneous isomerization and racemization of L-aspartyl and L-asparaginyl residues in aging peptides and proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>[protein]-L-isoaspartate + S-adenosyl-L-methionine = [protein]-L-isoaspartate alpha-methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:12705"/>
            <dbReference type="Rhea" id="RHEA-COMP:12143"/>
            <dbReference type="Rhea" id="RHEA-COMP:12144"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90596"/>
            <dbReference type="ChEBI" id="CHEBI:90598"/>
            <dbReference type="EC" id="2.1.1.77"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:12706"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.77" evidence="10"/>
    <dbReference type="EMBL" id="KB467843">
        <property type="protein sequence ID" value="PCH35062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3IYK5"/>
    <dbReference type="STRING" id="742152.A0A2H3IYK5"/>
    <dbReference type="OMA" id="HMHASAC"/>
    <dbReference type="OrthoDB" id="73890at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004719">
        <property type="term" value="F:protein-L-isoaspartate (D-aspartate) O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000235">
        <property type="entry name" value="Protein-L-isoaspartate O-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000682">
        <property type="entry name" value="PCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00080">
        <property type="entry name" value="pimt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11579">
        <property type="entry name" value="PROTEIN-L-ISOASPARTATE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11579:SF0">
        <property type="entry name" value="PROTEIN-L-ISOASPARTATE(D-ASPARTATE) O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01135">
        <property type="entry name" value="PCMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01279">
        <property type="entry name" value="PCMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 10" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00054057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PCH35062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="230" mass="24851" checksum="F07C1566A3DC47E4" modified="2018-01-31" version="1">MAWTCTGATNAELIKNMAKHGLINSARVQAAMSKVDRSNYVRNKHYAYEDSPQTIGYGATISAPHMHAHALEYLLPLLRPGARVLDVGSGSGYLCAVLHHLVSDPESGTTGQVVGIEHIPELVEWSVSNLRRDGLGSALDGAIEMVTGDGRQGYPSFAPYDAIHVGAAAPTMPQPLIEQLARPGRMFIPVGTDAQVIIQVDKDASGNITQKELFDVMYVPLMDREKQAVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IZ88</accession>
    <name>A0A2H3IZ88_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidyl-prolyl cis-trans isomerase</fullName>
            <ecNumber evidence="5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WOLCODRAFT_139849</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="5"/>
    <dbReference type="EMBL" id="KB467843">
        <property type="protein sequence ID" value="PCH35312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3IZ88"/>
    <dbReference type="STRING" id="742152.A0A2H3IZ88"/>
    <dbReference type="OMA" id="DEVQCLH"/>
    <dbReference type="OrthoDB" id="2530521at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060255">
        <property type="term" value="P:regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080090">
        <property type="term" value="P:regulation of primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000010">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase Pin1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051370">
        <property type="entry name" value="PPIase_Pin1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000297">
        <property type="entry name" value="PPIase_PpiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10657">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10657:SF4">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00639">
        <property type="entry name" value="Rotamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50198">
        <property type="entry name" value="PPIC_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 5" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="WW" evidence="6">
        <location>
            <begin position="5"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="PpiC" evidence="7">
        <location>
            <begin position="62"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PCH35312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="173" mass="19227" checksum="A3B67555EC72A6F3" modified="2018-01-31" version="1">MSSLGWEVRLSNSRKVPYYYHTESRESSWEPPAELTEEQVHELPGAKDYLLGQGAQGPDGRPVQVRASHLLVKHRDSRRPSSWKEANITRTKEEAIEILEGYAAEINSSTEKFAELARAHSDCSSHANNGDLGFFKPGQMQKAFEDATYALNVGQISDVVSTESGVHLILRTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IZJ5</accession>
    <name>A0A2H3IZJ5_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">5-formyltetrahydrofolate cyclo-ligase</fullName>
            <ecNumber evidence="5 7">6.3.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WOLCODRAFT_139897</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4 7">
            <text>(6S)-5-formyl-5,6,7,8-tetrahydrofolate + ATP = (6R)-5,10-methenyltetrahydrofolate + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10488"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.2" evidence="5 7"/>
    <dbReference type="EMBL" id="KB467843">
        <property type="protein sequence ID" value="PCH35410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3IZJ5"/>
    <dbReference type="STRING" id="742152.A0A2H3IZJ5"/>
    <dbReference type="OMA" id="DKWGIPT"/>
    <dbReference type="OrthoDB" id="2015992at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030272">
        <property type="term" value="F:5-formyltetrahydrofolate cyclo-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009396">
        <property type="term" value="P:folic acid-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10420">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002698">
        <property type="entry name" value="FTHF_cligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024185">
        <property type="entry name" value="FTHF_cligase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02727">
        <property type="entry name" value="MTHFS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23407:SF1">
        <property type="entry name" value="5-FORMYLTETRAHYDROFOLATE CYCLO-LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23407">
        <property type="entry name" value="ATPASE INHIBITOR/5-FORMYLTETRAHYDROFOLATE CYCLO-LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01812">
        <property type="entry name" value="5-FTHF_cyc-lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006806">
        <property type="entry name" value="FTHF_cligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="8"/>
            <end position="12"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="150"/>
            <end position="158"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00036539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR006806-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PCH35410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="217" mass="23464" checksum="8F8B7618D1951AA1" modified="2018-01-31" version="1">MASMQGQKSAVRAAVAAKLRLLPQSDIARQSQMAVGRVLAAPFFAQSTNVSCYLSMPAGELETAALVSEILRAGKTLFVPKIDPSARGKMDFLKVYGEDDLSSLSSGLWGIREPEYEWQGQPRLNALDEAAGQLDLILVPGVAFDRSLSRVGHGKGYYDRFISAYTRSKCANAQRKPLLVALALREQILEAGQVPTALHDWKMDVIVGPDGIIMGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IZQ7</accession>
    <name>A0A2H3IZQ7_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerases I and III subunit RPAC1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WOLCODRAFT_166280</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467854">
        <property type="protein sequence ID" value="PCH35460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3IZQ7"/>
    <dbReference type="STRING" id="742152.A0A2H3IZQ7"/>
    <dbReference type="OMA" id="KKKCRAF"/>
    <dbReference type="OrthoDB" id="270173at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055029">
        <property type="term" value="C:nuclear DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07032">
        <property type="entry name" value="RNAP_I_II_AC40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.120.12:FF:000003">
        <property type="entry name" value="Dna-directed rna polymerases i and iii subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.12">
        <property type="entry name" value="DNA-directed RNA polymerase, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00320">
        <property type="entry name" value="RNApol_arch_Rpo3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001514">
        <property type="entry name" value="DNA-dir_RNA_pol_30-40kDasu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011262">
        <property type="entry name" value="DNA-dir_RNA_pol_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011263">
        <property type="entry name" value="DNA-dir_RNA_pol_RpoA/D/Rpb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022842">
        <property type="entry name" value="RNAP_Rpo3/Rpb3/RPAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033901">
        <property type="entry name" value="RNAPI/III_AC40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036643">
        <property type="entry name" value="RNApol_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050518">
        <property type="entry name" value="Rpo3/RPB3_RNA_Pol_subunit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001988">
        <property type="entry name" value="PRK00783.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800:SF13">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01000">
        <property type="entry name" value="RNA_pol_A_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01193">
        <property type="entry name" value="RNA_pol_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00662">
        <property type="entry name" value="RPOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56553">
        <property type="entry name" value="Insert subdomain of RNA polymerase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00446">
        <property type="entry name" value="RNA_POL_D_30KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RpoA/D/Rpb3-type" evidence="8">
        <location>
            <begin position="71"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="360"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PCH35460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="386" mass="42710" checksum="48ABBD10C6422173" modified="2018-01-31" version="1">MASTFSAHAGPSSLPSSALNPRRHVNVHAEHVSDVSNTEYPGHYPGEDHSWNLAKFEKSLRVEVQRLSQRSIEFDLVGVDASIANAFRRIMIAEVPTMAIERVYVYNNTSVIHDEVLAHRLGLVPLDVNPRLFEFVHEDKEGKLTDRNTLVFSLDVTCEADKSGPREKGAPRRYINEYVTSGDLIFRPAGEQVSVLSEGSANYSPGPTNKNIVLAKLRPGQQIEMELHAVKGVGKEHAKWSPVATASYRLHPLILLNPSKPVPPHLAEKFARCFSPGVVQIGSNGEVSIDQRAMRKESMSREVFRHKEFEGCVQLKRIRDWFIYTVESEGPHPPQELLPEAIQVMRSKIADIRRAAEALLAGADGEQEGAGQGQGDGDGDVSMRDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IZX5</accession>
    <name>A0A2H3IZX5_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_27961</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
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                <person name="Kohler A."/>
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                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
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                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
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                <person name="Ohm R.A."/>
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                <person name="Sabat G."/>
                <person name="Salamov A."/>
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                <person name="Schmutz J."/>
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                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Barry K."/>
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                <person name="Ferreira P."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Barry K."/>
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                <person name="Benoit I."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <comment type="function">
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    </dbReference>
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        <location>
            <begin position="170"/>
            <end position="197"/>
        </location>
    </feature>
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            <begin position="69"/>
            <end position="111"/>
        </location>
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            <end position="83"/>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00025191"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH36130.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="702" mass="79277" checksum="C758582F3C026FD3" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J1L1</accession>
    <name>A0A2H3J1L1_WOLCO</name>
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        <recommendedName>
            <fullName evidence="4">Copper transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WOLCODRAFT_140206</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD-104</strain>
        </source>
    </reference>
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        <subcellularLocation>
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            <topology evidence="4">Multi-pass membrane protein</topology>
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    <comment type="similarity">
        <text evidence="4">Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.</text>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SOLUTE CARRIER FAMILY 31 COPPER TRANSPORTERS"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF04145">
        <property type="entry name" value="Ctr"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="4" id="KW-0187">Copper transport</keyword>
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    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="150"/>
            <end position="166"/>
        </location>
    </feature>
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    </evidence>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU367022"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH36066.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="188" mass="20668" checksum="C99DFE7FA7A3D75F" modified="2018-01-31" version="1">MDHGDHQMPMPTGPRCSMNMLWNTQIEDTCIVFRSWHVSSKTVFALSFFAIVALGVLYEWLRVAQRDVDRLIARRLIAEGKGKARVRSGRNTPSESDSEGAALLSGAQALKPKTGTPLPIFTRVIRALLYALTVFLSFFLMLVFMTYNAYLILAVVVGAGIGHFVFGSHMDINSVMAGAVDSKGMACH</sequence>
</entry>
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    <accession>A0A2H3J2D6</accession>
    <name>A0A2H3J2D6_WOLCO</name>
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        <recommendedName>
            <fullName evidence="4">Heparinase II/III-like C-terminal domain-containing protein</fullName>
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    </protein>
    <gene>
        <name evidence="5" type="ORF">WOLCODRAFT_135402</name>
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        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
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                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
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                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell envelope</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH33933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OMA" id="YWGYGTS"/>
    <dbReference type="OrthoDB" id="3476529at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.100">
        <property type="entry name" value="Chondroitin AC/alginate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Chondroitin_lyas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012480">
        <property type="entry name" value="Hepar_II_III_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38045">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38045:SF1">
        <property type="entry name" value="HEPARINASE II_III-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07940">
        <property type="entry name" value="Hepar_II_III_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48230">
        <property type="entry name" value="Chondroitin AC/alginate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="Heparinase II/III-like C-terminal" evidence="4">
        <location>
            <begin position="527"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="141"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PCH33933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="795" mass="87116" checksum="D3A47B1974C0D25F" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J2F5</accession>
    <name>A0A2H3J2F5_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_156583</name>
    </gene>
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                <person name="Barry K."/>
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                <person name="Coutinho P.M."/>
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                <person name="Heitman J."/>
                <person name="Hesse C."/>
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                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
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                <person name="Sabat G."/>
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            <dbReference type="DOI" id="10.1126/science.1221748"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH37142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="244" mass="27609" checksum="4772A69420FA112F" modified="2018-01-31" version="1">MIPRVTSGLGTVQRDVVSSRLRPAAAHDHCARASDGHGNELGETTPGAAIYDRRRRYVCCESWKREGRTRQDTRRRVTIAETLFNLPTTANHSNPTVDMRGTVEPAYPSFAFVLSYTDNDTRRSSSCRESHRRRYHPYSSKPRRQPPSTPMVNQNTADYRYEDALRIATSLLAYTPNAVAGRNAQNPQNLDRAHHPAGHPIDKPKRRHRLSDLIVDLALAARRRLARTGALQKLAFPVWFDLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J4S3</accession>
    <name>A0A2H3J4S3_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_157957</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467920">
        <property type="protein sequence ID" value="PCH37252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J4S3"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH37252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="137" mass="14410" checksum="81BAC708DEB8A26B" modified="2018-01-31" version="1">MTHAMKPGIHCSYPSAYGPRGVLMPAHSLLHELRAFPVAATLEHELRGEVYEVLLLAAAAAAATATARLQLLQPCQPRGILPLQVGHHRVAAIEPPLAGFSTSEHTDARQDALACANLAADIIELLDADSLGAEGHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J5U9</accession>
    <name>A0A2H3J5U9_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_148562</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH37622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J5U9"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH37622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="274" mass="31628" checksum="630CDF0D89444F24" modified="2018-01-31" version="1">MWTPNLRLGAIATYMLNALIYRAGEREEELTLIKSSALYCHADEDPTCGDDDDNDNDEDFKDKVDELEHYVPIGDRQGLYFLARIVEDQQTYRLSKVQESELPPSHLLWLYRVSSTEDLATVDVCVRPVTTDIKHLRRDEPPVLNMELNGLNLRFWQTTAPMMLDGAEVTRDVILPRHVKVEEVQELDKKRQTMTTQHILPEDHTGGGVWILLNSWYFNPARFVVTLLPRSVDLESSDEDERRGCGRGRGRDHGQEDENEDEEEDKEERGMEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J5W2</accession>
    <name>A0A2H3J5W2_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WOLCODRAFT_110164</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 4-hydroxybenzoyl-CoA thioesterase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467931">
        <property type="protein sequence ID" value="PCH37596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J5W2"/>
    <dbReference type="STRING" id="742152.A0A2H3J5W2"/>
    <dbReference type="OMA" id="DNDAYGH"/>
    <dbReference type="OrthoDB" id="2420454at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00586">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000104">
        <property type="entry name" value="Thioesterase family protein (AFU_orthologue AFUA_2G16350)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050563">
        <property type="entry name" value="4-hydroxybenzoyl-CoA_TE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31793">
        <property type="entry name" value="4-HYDROXYBENZOYL-COA THIOESTERASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31793:SF27">
        <property type="entry name" value="NOVEL THIOESTERASE SUPERFAMILY DOMAIN AND SAPOSIN A-TYPE DOMAIN CONTAINING PROTEIN (0610012H03RIK)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="3">
        <location>
            <begin position="30"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PCH37596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="155" mass="17497" checksum="A6CA91717546DFCE" modified="2018-01-31" version="1">MPTQLKSRKRSDYIYFLSYRTRWSDNDQYSHVNNSVYYHLFDSVVNTYLIAHCRLSPTKSPLIGLVVSSFCEFYSPISFPDVVDLGLRVAKLGKSSVTYEVGVFKEGESAPSAVGGYTHVFVESRSRKSAPMSEEMRDGLLRLHSAVVDRDAAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J665</accession>
    <name>A0A2H3J665_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">6,7-dimethyl-8-ribityllumazine synthase</fullName>
            <shortName evidence="7">DMRL synthase</shortName>
            <ecNumber evidence="3 7">2.5.1.78</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WOLCODRAFT_135821</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>(2S)-2-hydroxy-3-oxobutyl phosphate + 5-amino-6-(D-ribitylamino)uracil = 6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:26152"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58201"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="2.5.1.78"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Cofactor biosynthesis; riboflavin biosynthesis; riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DMRL synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.78" evidence="3 7"/>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH37742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J665"/>
    <dbReference type="STRING" id="742152.A0A2H3J665"/>
    <dbReference type="OMA" id="CQGVTQG"/>
    <dbReference type="OrthoDB" id="2965at2759"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00404"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009349">
        <property type="term" value="C:riboflavin synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000906">
        <property type="term" value="F:6,7-dimethyl-8-ribityllumazine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd09209">
        <property type="entry name" value="Lumazine_synthase-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.960:FF:000005">
        <property type="entry name" value="6,7-dimethyl-8-ribityllumazine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.960">
        <property type="entry name" value="Lumazine/riboflavin synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00178">
        <property type="entry name" value="Lumazine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034964">
        <property type="entry name" value="LS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002180">
        <property type="entry name" value="LS/RS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036467">
        <property type="entry name" value="LS/RS_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00114">
        <property type="entry name" value="lumazine-synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21058:SF0">
        <property type="entry name" value="6,7-DIMETHYL-8-RIBITYLLUMAZINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21058">
        <property type="entry name" value="6,7-DIMETHYL-8-RIBITYLLUMAZINE SYNTHASE DMRL SYNTHASE LUMAZINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00885">
        <property type="entry name" value="DMRL_synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52121">
        <property type="entry name" value="Lumazine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PCH37742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="211" mass="22073" checksum="451E49FE1C4B6E91" modified="2018-01-31" version="1">MSSIKGPAPPPTKFDGLPLRIAIVHSRWNKTVIDALVAGTVAKLREQGVKESNIVIQSVPGSFELPLACSKVIAGSHVQAGATATDLLGGLNFGSMNSPRPGSRASTPAPAVTAMPSQPFDAVIAIGVLIKGSTMHFEYICDSVSHALMRVQLDTGVPVIFGVLTALSDDQALERAGIGRGESKGHNHGEDWAAAAVEMASHSRRWGEGKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J692</accession>
    <name>A0A2H3J692_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Thioredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WOLCODRAFT_148729</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH37772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J692"/>
    <dbReference type="STRING" id="742152.A0A2H3J692"/>
    <dbReference type="OMA" id="VLVIMQN"/>
    <dbReference type="OrthoDB" id="2121326at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000001">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01068">
        <property type="entry name" value="thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45663">
        <property type="entry name" value="GEO12009P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45663:SF11">
        <property type="entry name" value="GEO12009P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Thioredoxin" evidence="5">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PCH37772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="140" mass="15553" checksum="1FED997FFC252096" modified="2018-01-31" version="1">MSSLATLRVLRARTACTPGRSFHSTPLRREHFLKANVETFTKAISNKDKVVLVDFYADWCNPCKMLSPILESVTSDPNVKSGSGLPLDLVTIDTDNEIELAQQYNIRSLPTVLAFKDGQPAHRFVGALPEAQVRAWLRAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J6F7</accession>
    <name>A0A2H3J6F7_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ARM repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WOLCODRAFT_66238</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH37830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J6F7"/>
    <dbReference type="STRING" id="742152.A0A2H3J6F7"/>
    <dbReference type="OMA" id="IGYLFCA"/>
    <dbReference type="OrthoDB" id="29308at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030117">
        <property type="term" value="C:membrane coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050840">
        <property type="entry name" value="Adaptor_Complx_Large_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22780">
        <property type="entry name" value="ADAPTIN, ALPHA/GAMMA/EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="6">
        <location>
            <begin position="39"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="609"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="609"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="625"/>
            <end position="636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PCH37830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="846" mass="93889" checksum="1A9ACF4A801D5326" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J6R2</accession>
    <name>A0A2H3J6R2_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WOLCODRAFT_129711</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
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        <property type="protein sequence ID" value="PCH33338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="742152.A0A2H3J6R2"/>
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    <dbReference type="OrthoDB" id="123929at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24115:SF1008">
        <property type="entry name" value="KINESIN-LIKE PROTEIN SUBITO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24115">
        <property type="entry name" value="KINESIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="4 5 6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="2 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="9">
        <location>
            <begin position="73"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="685"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="714"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="616"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="15"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="740"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="768"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="822"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="877"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="166"/>
            <end position="173"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PCH33338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="962" mass="105917" checksum="0E8D5F2C1CC4960C" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J6S3</accession>
    <name>A0A2H3J6S3_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">D-aminoacyl-tRNA deacylase</fullName>
            <ecNumber evidence="2 6">3.1.1.96</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WOLCODRAFT_96112</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a D-aminoacyl-tRNA + H2O = a tRNA + a D-alpha-amino acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13953"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:10124"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
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            <dbReference type="ChEBI" id="CHEBI:79333"/>
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        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>glycyl-tRNA(Ala) + H2O = tRNA(Ala) + glycine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53744"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
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        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the DTD family.</text>
    </comment>
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        <property type="entry name" value="Daa-tRNA_deacyls_DTD"/>
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        <location>
            <begin position="155"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009673"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00047676"/>
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    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003470"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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            <dbReference type="EMBL" id="PCH37916.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
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    <sequence length="187" mass="20227" checksum="B9F3DF45CF7B4FB7" modified="2018-01-31" version="1">MRAVVQRVASASVTVDNEVISSISRGLMVLVGIGKDDTMADVETISNKILNLRIFSDASGAMWKKSVKDIDGEVLCVSQFTLLANTTKGNKPDFHRAMATEPGKQLYTTFLEKMSSLYKPEKIQDGRFGAMMNVSLTNEGPVTFTLDSRKFEYVDQSAGSSGDGSKTGKAATPKQKPPAQLVQDPSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J6T4</accession>
    <name>A0A2H3J6T4_WOLCO</name>
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        <recommendedName>
            <fullName evidence="11">Kinase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WOLCODRAFT_135720</name>
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    <organism evidence="9 10">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9 10">MD-104</strain>
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        <property type="entry name" value="PROTEIN_KINASE_ST"/>
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    <keyword evidence="4" id="KW-0418">Kinase</keyword>
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    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
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        <location>
            <begin position="470"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="8">
        <location>
            <begin position="772"/>
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        </location>
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            <begin position="1"/>
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    </feature>
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        <location>
            <begin position="877"/>
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    </feature>
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        <location>
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        <location>
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        <location>
            <begin position="1087"/>
            <end position="1114"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1127"/>
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        </location>
    </feature>
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        <location>
            <begin position="1140"/>
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    </feature>
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        <location>
            <begin position="1175"/>
            <end position="1202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH34449.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1249" mass="134410" checksum="788022E1D96E60CD" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J880</accession>
    <name>A0A2H3J880_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WOLCODRAFT_136270</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
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                <person name="St John F."/>
                <person name="Stenlid J."/>
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                <person name="Sun S."/>
                <person name="Syed K."/>
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                <person name="Wiebenga A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
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                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
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                <person name="Kumar T.K.A."/>
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                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
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                <person name="Nagy L.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7 8">MD-104</strain>
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        <location>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    <sequence length="161" mass="18522" checksum="8E033CC2B99FC18C" modified="2018-01-31" version="1">MVLLVTSDNEQFVVDKEVAERSVLIKNMLEDVGESDQPIPLPNVSSSVLKKVLEYCEHHRGEPLPTTESDQSQDETRKRTTDISEWDQKFITVDQEMLFEIILAANYLDIKPLLDVGCKTVANMIKGKTPEEIRKLFNIVNDFTPEEEAQIKKENEWAEDR</sequence>
</entry>
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    <name>A0A2H3J8Y0_WOLCO</name>
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            <fullName evidence="18">SNF2-family ATP dependent chromatin remodeling factor snf21</fullName>
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            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
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                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
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                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
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                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
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                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
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</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
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                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
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                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
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                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
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                <person name="Eastwood D.C."/>
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            <dbReference type="DOI" id="10.1126/science.1221748"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD-104</strain>
        </source>
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        <cofactor evidence="1">
            <name>FAD</name>
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    <comment type="similarity">
        <text evidence="2">Belongs to the PheA/TfdB FAD monooxygenase family.</text>
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        <source>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        <source>
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        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH36583.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="556" mass="61152" checksum="A50492AE9AE1A676" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J9Z7</accession>
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            <fullName evidence="3">Uncharacterized protein</fullName>
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        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Agaricomycetes</taxon>
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        </lineage>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
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        <location>
            <begin position="31"/>
            <end position="61"/>
        </location>
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        </location>
    </feature>
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        </location>
    </feature>
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            <begin position="255"/>
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        </location>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH39092.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
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                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
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                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
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                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
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        </location>
    </feature>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    <name>A0A2H3JAN4_WOLCO</name>
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            <fullName evidence="1">Helicase MOV-10-like beta-barrel domain-containing protein</fullName>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
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                <person name="Morin E."/>
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                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049080">
        <property type="entry name" value="MOV-10-like_beta-barrel"/>
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        <property type="entry name" value="MOV-10_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase MOV-10-like beta-barrel" evidence="1">
        <location>
            <begin position="71"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH39290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="215" mass="23987" checksum="AC92B545C099C651" modified="2018-01-31" version="1">MLNMPEPELNAILMLRPLTWNLAEAINNLAHQARVKGFLPGGLSIWNYSEFWKVLLHLEEDMQSMELSCYNLSNTEMKAVYPKYRLSVPGLSEGKPSAIVGDKILVKKSNDDSDSWYMGIVHAIGFKELDLYVNGGFSLHRSGNKVDVRFQLLTPARILFPEGRHTDGLRRCSEAQLVSLNLMNAAMADHLEQLEAVVAIANMPPGSVAFVVFTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JAT3</accession>
    <name>A0A2H3JAT3_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Calcium uniporter protein, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">WOLCODRAFT_109395</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Highly selective calcium channel localized to the inner mitochondrial membrane, which mediates calcium uptake into the mitochondrial matrix. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates ATP production, cytoplasmic calcium signals and activation of cell death pathways. Sufficient to operate as a pore-forming channel without the need of calcium-sensor or auxiliary subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>Ca(2+)(in) = Ca(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29671"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homotetramer, assembles in a dimer or dimers configuration with two interfaces.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MCU (TC 1.A.77) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467898">
        <property type="protein sequence ID" value="PCH36923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JAT3"/>
    <dbReference type="STRING" id="742152.A0A2H3JAT3"/>
    <dbReference type="OMA" id="IKHECDA"/>
    <dbReference type="OrthoDB" id="278338at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990246">
        <property type="term" value="C:uniplex complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015292">
        <property type="term" value="F:uniporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036444">
        <property type="term" value="P:calcium import into the mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051560">
        <property type="term" value="P:mitochondrial calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006769">
        <property type="entry name" value="MCU_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039055">
        <property type="entry name" value="MCU_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13462">
        <property type="entry name" value="CALCIUM UNIPORTER PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13462:SF10">
        <property type="entry name" value="CALCIUM UNIPORTER PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04678">
        <property type="entry name" value="MCU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="4" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="288"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="Calcium uniporter protein C-terminal" evidence="20">
        <location>
            <begin position="216"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="60"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="106"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="370"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="107"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="370"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="411"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00036634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00044981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00045938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF04678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="PCH36923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="428" mass="48483" checksum="A7ECC7723A18ABD9" modified="2018-01-31" version="1">MFRILFESQARTLVQHSPWQHSPRTWNLSKRWVTTAQQVENTNVSHSRFLAEASTKAKWKDSEEVGKGGTEATADDLDSITEGKGKLSPTSSHLFKLILPLGHLRAQQQPQQSNDSPSSSTKIKPPPPTVFLLHPSQPLSHVARLILASLAPEMPTVSFRSTTPSGRSLKWADSTDVGNFIRDAARACEFEIYVGEEGAQADDRRVQAMIQVEVPSFADRTRFLRRRLNVIEEELEKMEVLKRACDVEAHRGARRMAMGGLGALVVYWGATARLTFWDLGWDVMEPVTYLSGLSMVIIGYLWFLYQGREVSYSSVLQRSVSARRETLYKARGLDIERWLDLVSEAKALRKEIGQIAEDYDERLWRERQAERHAHEHEQERVRTEEADKAEAGLAKMPDEESSAARDSPQVESEREEVGRANKEAKDGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JBM1</accession>
    <name>A0A2H3JBM1_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_167882</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467976">
        <property type="protein sequence ID" value="PCH39301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JBM1"/>
    <dbReference type="STRING" id="742152.A0A2H3JBM1"/>
    <dbReference type="OrthoDB" id="2804258at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="542"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="542"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="555"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH39301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="585" mass="65136" checksum="4C71FE439A7AFBBC" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JBQ9</accession>
    <name>A0A2H3JBQ9_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Carboxylesterase type B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_20391</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
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                <person name="Kohler A."/>
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                <person name="Kumar T.K.A."/>
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                <person name="Salamov A."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">MD-104</strain>
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    </evidence>
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    </evidence>
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    <sequence length="117" mass="13359" checksum="F4D780FB64E4FA0D" modified="2018-01-31" version="1">MQKLGSPYALGNFLAGQPFYDDLVDHVNCSHHLDTLYCLRKASYEQIQAWVNSTPKFFGYESINLVWQPRIDEDIFIQNPQRSMIMGRYAMVPLLTGDCDDEGTLFSTGNTNITYVP</sequence>
</entry>
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            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
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                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
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                <person name="Benoit I."/>
                <person name="Boyd A."/>
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                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
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                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6 7">MD-104</strain>
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    </evidence>
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    <sequence length="509" mass="53677" checksum="CF29D8C58B6F2EF4" modified="2018-01-31" version="1">MFDCIVVGSGHAGSCAALSAVEAGCRRVLIVEKAPREWAGGNGFFTAGAHRTVHGGLHDFLPIVRNAPPEVVSTIDMEPYTAEQFTADIMRLGDNRADPAIVRAVVDGSRDAVGWLADQVGVPFTFSFNRQAYLVDGRQKFWGGLVLSVDDGGRGLIAAHQRALEQAGVETWFETPAVELLTEDGAVSGVVVLRSGESVRLRSRAVVLACGGFEASAELRAEHLGPEWLKAKVRGTPYNTGDGLSLARGAGAALAGDFAHCHATCWDAHAPDAHGDRVLLNQLTKSGYPLGVLANAHGVRFADEGADFRNYTYARLGRAVLRQPGAFAFQLFDPRAARWLRAEEYADAVVAATRAESLSALADKLVAHGLADRDALLATLHGYNGAVRAARAEHPERAWDPAVKDGLSTESARAGCDPPKSNWALPLEEPPFVAVKVACGITFTFGGLAIDPRTAGVLAERTATPIRGLFCTGELVGGLFFGNYPGGSGLTAGAVFGRMAGREAAKLAA</sequence>
</entry>
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            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Sabat G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH39810.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="62" mass="6540" checksum="6DA6D86512DD2096" modified="2018-01-31" version="1">MKQTSPHRSLGLALHGSAQPRPSRGFHLGQLHRYARAFPNVDGAPSGASSQRRAAPHTSAGV</sequence>
</entry>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Kuo A."/>
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                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD-104</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nudE family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH33817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="742152.A0A2H3JCY6"/>
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    <dbReference type="OrthoDB" id="5877028at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005871">
        <property type="term" value="C:kinesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051642">
        <property type="term" value="P:centrosome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000132">
        <property type="term" value="P:establishment of mitotic spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047496">
        <property type="term" value="P:vesicle transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033494">
        <property type="entry name" value="NUDE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006964">
        <property type="entry name" value="NUDE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10921:SF1">
        <property type="entry name" value="NUCLEAR DISTRIBUTION PROTEIN NUDE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10921">
        <property type="entry name" value="NUCLEAR DISTRIBUTION PROTEIN NUDE HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04880">
        <property type="entry name" value="NUDE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NUDE" evidence="8">
        <location>
            <begin position="150"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="203"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="362"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="593"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="621"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="208"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="221"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
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            <begin position="261"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="276"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="291"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="391"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="441"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PCH33817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="641" mass="69619" checksum="EA6BB3BB85ADD117" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JDC6</accession>
    <name>A0A2H3JDC6_WOLCO</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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        <name evidence="2" type="ORF">WOLCODRAFT_141890</name>
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    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
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                <person name="Martin R."/>
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                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
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                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89372">
        <property type="entry name" value="Fucose-specific lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH33957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JDU9</accession>
    <name>A0A2H3JDU9_WOLCO</name>
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        <submittedName>
            <fullName evidence="11">Cytochrome P450</fullName>
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        <name evidence="11" type="ORF">WOLCODRAFT_24093</name>
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    <organism evidence="11 12">
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            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
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                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD-104</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468053">
        <property type="protein sequence ID" value="PCH40422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OMA" id="KPWQSRR"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11069">
        <property type="entry name" value="CYP_FUM15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9 10" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="453"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PCH40422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="518" mass="58095" checksum="1F397D3998C87EB5" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JDW0</accession>
    <name>A0A2H3JDW0_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WOLCODRAFT_136866</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468053">
        <property type="protein sequence ID" value="PCH40420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JDW0"/>
    <dbReference type="STRING" id="742152.A0A2H3JDW0"/>
    <dbReference type="OMA" id="CRNAAMR"/>
    <dbReference type="OrthoDB" id="10254455at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140567">
        <property type="term" value="F:membrane protein dislocase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140570">
        <property type="term" value="P:extraction of mislocalized protein from mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000538">
        <property type="entry name" value="ATPase family AAA domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051701">
        <property type="entry name" value="Mito_OM_Translocase_MSP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45644">
        <property type="entry name" value="AAA ATPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G12920)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45644:SF3">
        <property type="entry name" value="FI08533P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="8">
        <location>
            <begin position="87"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="287"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PCH40420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="322" mass="35652" checksum="91BDD136282486A9" modified="2018-01-31" version="1">MDGVLPGNERKEVKAKSLKALEKLGHKDLQLDEYEKQIASEVIHPDDIDVRFTDIGGLEPIIASLRESVIYPLVYPHLFTSSSLLGAPKGVLLFGPPGCGKTMLAKALAKESGATFINIAASVLTNKWYGESNKLVAALFSLARKTQPSIVFIDEIDSFLRERTKGDHEVTGMMKAEFMTLWDGLTSSTDRILVLGATNRPNDIDSAILRRMPKRFSVGLPDLEQRQKILNLMLKDTELDKSFSISTLAQQFDGLSGSELKELCRNAAMQPMREFIRESGDDHEMLARSQEEGFKLRPLTLEDFSQSDGTDALPPLDGVPLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JEN3</accession>
    <name>A0A2H3JEN3_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WOLCODRAFT_136944</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS12 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH40690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JEN3"/>
    <dbReference type="STRING" id="742152.A0A2H3JEN3"/>
    <dbReference type="OMA" id="CAEHQIP"/>
    <dbReference type="OrthoDB" id="10249311at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022626">
        <property type="term" value="C:cytosolic ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000005">
        <property type="entry name" value="40S ribosomal protein S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000530">
        <property type="entry name" value="Ribosomal_eS12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047860">
        <property type="entry name" value="Ribosomal_eS12_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11843">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S12"/>
        <property type="match status" value="1"/>
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                <person name="Heitman J."/>
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    </dbReference>
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            <begin position="1086"/>
            <end position="1241"/>
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            <begin position="1802"/>
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            <end position="344"/>
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        </source>
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</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JGG6</accession>
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        </lineage>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
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                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
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        </location>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
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</entry>
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    <accession>A0A2H3JGQ5</accession>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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        <name evidence="1" type="ORF">WOLCODRAFT_28209</name>
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        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
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                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
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                <person name="Ferreira P."/>
                <person name="Findley K."/>
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                <person name="Heitman J."/>
                <person name="Hesse C."/>
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                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="PCH35894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="56" mass="6151" checksum="5BE1537A87C8FB78" modified="2018-01-31" version="1">MPAEDCDLRPFNAAALVEDFRPSRALCHASLWTTARRCLLIAYTPLLVSHPAAARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JHE8</accession>
    <name>A0A2H3JHE8_WOLCO</name>
    <protein>
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            <fullName evidence="6">Cytoplasmic tRNA 2-thiolation protein 1</fullName>
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        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Cytoplasmic tRNA adenylyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">NCS6</name>
        <name evidence="6" type="synonym">CTU1</name>
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    <organism evidence="10 11">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TtcA family. CTU1/NCS6/ATPBD3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.-" evidence="6"/>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH41602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JHE8"/>
    <dbReference type="STRING" id="742152.A0A2H3JHE8"/>
    <dbReference type="OMA" id="KPVRGIC"/>
    <dbReference type="OrthoDB" id="198857at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002144">
        <property type="term" value="C:cytosolic tRNA wobble base thiouridylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032447">
        <property type="term" value="P:protein urmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01713">
        <property type="entry name" value="CTU1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000054">
        <property type="entry name" value="Cytoplasmic tRNA 2-thiolation protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03053">
        <property type="entry name" value="CTU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056369">
        <property type="entry name" value="CTU1-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032442">
        <property type="entry name" value="CTU1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000541">
        <property type="entry name" value="Ncs6/Tuc1/Ctu1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011063">
        <property type="entry name" value="TilS/TtcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035107">
        <property type="entry name" value="tRNA_thiolation_TtcA_Ctu1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00269">
        <property type="entry name" value="TIGR00269 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11807">
        <property type="entry name" value="ATPASES OF THE PP SUPERFAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11807:SF12">
        <property type="entry name" value="CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01171">
        <property type="entry name" value="ATP_bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16503">
        <property type="entry name" value="zn-ribbon_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004976">
        <property type="entry name" value="ATPase_YdaO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 6" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2 6" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal" evidence="8">
        <location>
            <begin position="54"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Cytoplasmic tRNA 2-thiolation protein 1 C-terminal" evidence="9">
        <location>
            <begin position="283"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="57"/>
            <end position="59"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR004976-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PCH41602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="358" mass="40259" checksum="10877A62C155D6A7" modified="2018-01-31" version="1">MPPRNCALCHEARAILKRPKTGQQICRDCFFWVFETEVHNTITEAGLFKPGDRVAIGASGGKDSTVLAHVMKTLNDRYQYGLELFLLSIDEGITGYRDDSLETVKRNQQQYDMPLKILSYDELYGWTMDAIVSQVGKRNNCTFCGVFRRQALDRGASALHVDHIVTGHNADDIAETVLMNIMRGDIARLGRCTMICTQGEDTIKRSKPFKYAYEKEIVMYAYFKKLDYFSTECIYSPDAYRGHARAFLKDLEAARPSAIIDIIHSGEAFEVKEEIRATQKQQQTCKRCGYMSSNDLCKACTLLEGLERGIANAAITDRARKKLDAEGPAPENLRTIPFYQPSSTPNPALPVTIEGAHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JHF3</accession>
    <name>A0A2H3JHF3_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ferritin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_24864</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH41606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JHF3"/>
    <dbReference type="STRING" id="742152.A0A2H3JHF3"/>
    <dbReference type="OMA" id="NGPVAIW"/>
    <dbReference type="OrthoDB" id="1001765at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00657">
        <property type="entry name" value="Ferritin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052965">
        <property type="entry name" value="Pigment-catalase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31694">
        <property type="entry name" value="DESICCATION-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31694:SF26">
        <property type="entry name" value="OS05G0151100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13668">
        <property type="entry name" value="Ferritin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013628615" description="Ferritin-like domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH41606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="478" mass="47208" checksum="937AC0934E0D6BEA" modified="2018-01-31" version="1">MFPSLSVLALAVPLLVSGAPIHVKRANSTDVLVLQFAGVLEQLESEFYSQALAKFQDSDFTSAGFSDAQVPIQQFEAIGSDEATHLSVINSTLESLGASLISGCQFDFSDVLSNVSTMAATARVVENLGVAAYLGAANMITDPVLLTAAASIMSVEARHQTVLNLLSDATSIPQAFDIALTPSEVLAVASPFISGCEIPIQANPTLTVTNTGPAVPGTALTFTSSALNGSTDGLFCQMLVGGAATSISLNLSSCVVPDGINGPVAIFITSDDQPINNNIREQNTNFLVAGPTMVFVDANSDLLGQLAVTGSVSSNSTSSSNSSSSGSVSSSAASATSTSGSDSNSTAVASSTATASATSAASVSSSASEASATAVSVSASFSATAAASAASASATTELTSVITSTISPSQASVIISAASAAASETASTAASATESASAALASAGSSTDIVAFPGGPNMYVGPSADGSIYVLGWSTTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JHL4</accession>
    <name>A0A2H3JHL4_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_157916</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
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                <person name="Gorecki P."/>
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                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
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                <person name="Lindquist E."/>
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                <person name="Morgenstern I."/>
                <person name="Morin E."/>
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                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
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                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
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                <person name="Cullen D."/>
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        </citation>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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    </evidence>
    <sequence length="77" mass="8471" checksum="09C37417682E7BA6" modified="2018-01-31" version="1">MQTRWDVNLKLVQRAWVCDDASKRSAAPGVVVDLDVKKRDLVADVIAAVDAIVLKKHGHLPVDAAVKLQSSPELRED</sequence>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
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                <person name="Barry K."/>
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                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
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                <person name="Benoit I."/>
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                <person name="Ferreira P."/>
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                <person name="Hori C."/>
                <person name="Igarashi K."/>
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                <person name="Kallen N."/>
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                <person name="Kohler A."/>
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                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
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                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="143" mass="16426" checksum="A8F00B12FB6C1240" modified="2018-01-31" version="1">MDRLLAPQSPEAMAHTHLNENWFSWDTEHPSLNETLISGCAAYEAFKRYLSGTDLYLLPRSRNELESILRRYAYDCIHNTIAKARSPLERGGYSRICHLVEKSIGNVLSENNNAEYLLDMHHAHRNNVTADMGRSPTRSIRIK</sequence>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
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                <person name="Otillar R."/>
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                <person name="Yadav J.S."/>
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                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
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                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
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                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
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                <person name="Patyshakuliyeva A."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
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    </reference>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
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        </location>
    </feature>
    <feature type="chain" id="PRO_5013756373" description="Plasma membrane fusion protein PRM1" evidence="2">
        <location>
            <begin position="20"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="165" mass="18492" checksum="41D2218465237767" modified="2018-01-31" version="1">MPISCQMVFWLLAPIVGLAATSMFADRVHVDIDGQRDFARVIRELGIRETMTEMSGMLGEALDALTTNSAQMTANVERNMSSVSSDFHNATFYFRMLMIALTAYTVVLILRGIYGWICDVRREKDHDIVILITDGGFRVRGLLGQSTYVVSRRGTARRSRGTSYV</sequence>
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                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
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                <person name="Patyshakuliyeva A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH39843.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
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    </evidence>
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        <name type="common">Brown rot fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the DapA family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468124">
        <property type="protein sequence ID" value="PCH42222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JJ70"/>
    <dbReference type="STRING" id="742152.A0A2H3JJ70"/>
    <dbReference type="OMA" id="DMPIMLY"/>
    <dbReference type="OrthoDB" id="191315at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008840">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00408">
        <property type="entry name" value="DHDPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128:SF66">
        <property type="entry name" value="4-HYDROXY-2-OXOGLUTARATE ALDOLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="DIHYDRODIPICOLINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="3">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001365-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001365-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PCH42222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="310" mass="32680" checksum="363CFDFDB0E2D346" modified="2018-01-31" version="1">MSPANSIPPPPGVYVPAVVYFDDNEDLDIPALKAHVLRLAKGGITGILIQGSNGEAQHLSHEEKKEAIRVTRQTLDENGFQQVVVVAGTGALSTRETKKLCADAAEAGAGFCLVLTPSVWPGLMTPENILRFHREVADASPIPTMVYNFPVVTAGINLTSDIIGALAQHPNIVGTKLSCGDVGKLHRLTSSVPATKFATFPGVSDVFLQGLVSGSAGLIGALPNIAPKAHMEVYRLYKAGKITEAAKIQALLGHADWELTSLGSIGGIKAAVFKHWGYGNVNVRGPLGSVELTASTTSKLEELIAYEKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JJ83</accession>
    <name>A0A2H3JJ83_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Nucleoporin Nup120/160-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WOLCODRAFT_100880</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH41595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="742152.A0A2H3JJ83"/>
    <dbReference type="OMA" id="TLWKNNM"/>
    <dbReference type="OrthoDB" id="67716at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059141">
        <property type="entry name" value="Beta-prop_Nup120_160"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056548">
        <property type="entry name" value="HEAT_Nup120"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021717">
        <property type="entry name" value="Nucleoporin_Nup160"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056536">
        <property type="entry name" value="TPR_NUP160_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21286">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21286:SF0">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11715">
        <property type="entry name" value="Beta-prop_Nup120_160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23300">
        <property type="entry name" value="HEAT_Nup120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23347">
        <property type="entry name" value="TPR_Nup160_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup120/160 beta-propeller" evidence="5">
        <location>
            <begin position="62"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin nup120-like HEAT repeat" evidence="6">
        <location>
            <begin position="816"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="domain" description="NUP160 C-terminal TPR" evidence="7">
        <location>
            <begin position="1123"/>
            <end position="1369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="648"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="657"/>
            <end position="667"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF11715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF23347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PCH41595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1372" mass="153878" checksum="C3CC2F7E57450BA7" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JK01</accession>
    <name>A0A2H3JK01_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycosyltransferase family 15 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WOLCODRAFT_136028</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 15 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH38078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JK01"/>
    <dbReference type="STRING" id="742152.A0A2H3JK01"/>
    <dbReference type="OMA" id="GYRHNPF"/>
    <dbReference type="OrthoDB" id="439943at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000051">
        <property type="entry name" value="Alpha-1,2-mannosyltransferase (Ktr4)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002685">
        <property type="entry name" value="Glyco_trans_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121:SF6">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01793">
        <property type="entry name" value="Glyco_transf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018153">
        <property type="entry name" value="Glyco_trans_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013615081" evidence="4">
        <location>
            <begin position="24"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR018153-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PCH38078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="383" mass="44697" checksum="45435C8B3C85D9C8" modified="2018-01-31" version="1">MMTPMRYVVLVLAIIISLHFILSFSHEDYSRATSISRIAEQFKSDPAPAPAPVAKPPPYPSYEGSVDGVSPARKANATFVLLARNSDLPGIVSSMKQMEDRFNKHYKYPYVFLNEEPFSDEFKSRIQVLTDAPVEFGLISHDHWYQPEWIDEQKASAAREEMIRNQVIYGGSVPYRNMCRFNSGFFYRHELLAKYKYYWRIEPDVTFFCDLDYDPFLLMQDEKKVYGFTVSLYEYPATIPTLWSAVKEFIHDNSDLIPSGNAMAFISDDNGETYNNCHFWSNFEIGDLDFWRGEAYSKFFEFLDSKGGFYYERWGDAPVHSIGAALLAKKEQIHFFNEIGYRHNPFQHCPQGDLHAKGKCWCNPKDNFDYEWYSCLKRYDSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JKI7</accession>
    <name>A0A2H3JKI7_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pirin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WOLCODRAFT_65310</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD-104</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="2">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pirin family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH38248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JKI7"/>
    <dbReference type="STRING" id="742152.A0A2H3JKI7"/>
    <dbReference type="OMA" id="TPWHPHR"/>
    <dbReference type="OrthoDB" id="198735at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02247">
        <property type="entry name" value="cupin_pirin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02909">
        <property type="entry name" value="cupin_pirin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012093">
        <property type="entry name" value="Pirin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008778">
        <property type="entry name" value="Pirin_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003829">
        <property type="entry name" value="Pirin_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13903:SF8">
        <property type="entry name" value="PIRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13903">
        <property type="entry name" value="PIRIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02678">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05726">
        <property type="entry name" value="Pirin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006232">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pirin N-terminal" evidence="4">
        <location>
            <begin position="27"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Pirin C-terminal" evidence="5">
        <location>
            <begin position="188"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR006232-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PCH38248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="301" mass="32942" checksum="F42017886F0082E3" modified="2018-01-31" version="1">MSVSSVSRRVVKKVLAVETPEGEGALVRRSIGSMKLRNLTPFLMLDHFHVSKGAGFPDHPHRGQATVSYMLEGSSRHEDSAGHKGTIEAGGVQWMCAGRGIIHAEMPVQGPGHPDPRGLQLWVDLPKQFKMAEPSYQELGPNEIPSAYPEGPDGPVRIKVISGKSYGVESPVRPLGGCWYFHVIFDKKDTTIFQDIPAGWTSFIYTLKGSMKVGSEPNIHEAFHTLVLSGDADETGVQITATEDNTEAVVIAGEPLDQTVFQYGPFVMTSREEIQATLIDYQSARNGFEKAHTWKSKIGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JKK0</accession>
    <name>A0A2H3JKK0_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WOLCODRAFT_88653</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the putative lipase ROG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468053">
        <property type="protein sequence ID" value="PCH40383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JKK0"/>
    <dbReference type="STRING" id="742152.A0A2H3JKK0"/>
    <dbReference type="OMA" id="SIWHPLW"/>
    <dbReference type="OrthoDB" id="5592486at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007751">
        <property type="entry name" value="DUF676_lipase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11440">
        <property type="entry name" value="LECITHIN-CHOLESTEROL ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05057">
        <property type="entry name" value="DUF676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF676" evidence="3">
        <location>
            <begin position="192"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="71"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="266"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="355"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="414"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH42822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="603" mass="67600" checksum="79D1FABDDB144C14" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JKY0</accession>
    <name>A0A2H3JKY0_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4440 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_73732</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468135">
        <property type="protein sequence ID" value="PCH42850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JKY0"/>
    <dbReference type="OMA" id="WIQDRVT"/>
    <dbReference type="OrthoDB" id="3188871at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH42850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="126" mass="13606" checksum="EB3EBA5D243A4872" modified="2018-01-31" version="1">MSISLGPGPVIIPLTAWAEDSISALFKATADNFDSAFDSFLAEDVHITVNGKHLTREQYKQQILGEKALERTANVTFLNSVEVPKDENKPAQAGTVGLFYKAQIIEKLFVLGAPAGRTITSSVNLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JL27</accession>
    <name>A0A2H3JL27_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Complex 1 LYR protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_72840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I LYR family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468124">
        <property type="protein sequence ID" value="PCH42235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JL27"/>
    <dbReference type="STRING" id="742152.A0A2H3JL27"/>
    <dbReference type="OMA" id="HRAFMSK"/>
    <dbReference type="OrthoDB" id="10258445at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090324">
        <property type="term" value="P:negative regulation of oxidative phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20265">
        <property type="entry name" value="Complex1_LYR_ETFRF1_LYRM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045296">
        <property type="entry name" value="Complex1_LYR_ETFRF1_LYRM5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052000">
        <property type="entry name" value="ETFRF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21024:SF0">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN REGULATORY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21024">
        <property type="entry name" value="GROWTH HORMONE-INDUCIBLE SOLUBLE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="2">
        <location>
            <begin position="9"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH42235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="95" mass="11401" checksum="0DAA634B6F84BD03" modified="2018-01-31" version="1">MASKSSRLRAIALYKELHRLGRDYPDPSYNFHGKLRRLFEKNRGLKDPEDIEKALKLGEFIRNETLALYSLRKYRHLKRMYSDDPLSDPLRDYRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JMJ8</accession>
    <name>A0A2H3JMJ8_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Aminopeptidase</fullName>
            <ecNumber evidence="11">3.4.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">WOLCODRAFT_141023</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">MD-104</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9 11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-" evidence="11"/>
    <dbReference type="EMBL" id="KB467943">
        <property type="protein sequence ID" value="PCH38958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JMJ8"/>
    <dbReference type="STRING" id="742152.A0A2H3JMJ8"/>
    <dbReference type="OMA" id="MMEYVAI"/>
    <dbReference type="OrthoDB" id="10031169at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09601">
        <property type="entry name" value="M1_APN-Q_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.50.20:FF:000002">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000006">
        <property type="entry name" value="Puromycin-sensitive aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="tricorn interacting facor f3 domain"/>
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    </dbReference>
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        <property type="entry name" value="Aminopeptidase_N-like_N"/>
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    </dbReference>
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        <property type="entry name" value="ERAP1-like_C_dom"/>
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        <property type="entry name" value="M1_APN-typ"/>
    </dbReference>
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        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
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        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
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        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
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        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF174">
        <property type="entry name" value="PUROMYCIN-SENSITIVE AMINOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3 11" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="14">
        <location>
            <begin position="18"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="12">
        <location>
            <begin position="266"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1-like C-terminal" evidence="13">
        <location>
            <begin position="562"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="339"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="338"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="361"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="10">
        <location>
            <position position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PCH38958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="904" mass="101655" checksum="5178B17B32C2F30F" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JMX8</accession>
    <name>A0A2H3JMX8_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">KR-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WOLCODRAFT_73854</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD-104</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="PCH43241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
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        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
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        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="3">
        <location>
            <begin position="500"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PCH43241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="568" mass="61213" checksum="9AFC422B9964C34F" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JNL0</accession>
    <name>A0A2H3JNL0_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">2-methylcitrate dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WOLCODRAFT_26178</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PrpD family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468146">
        <property type="protein sequence ID" value="PCH43772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="742152.A0A2H3JNL0"/>
    <dbReference type="OMA" id="DHSVMYI"/>
    <dbReference type="OrthoDB" id="10055203at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047547">
        <property type="term" value="F:2-methylcitrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019679">
        <property type="term" value="P:propionate metabolic process, methylcitrate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="2-methylcitrate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.120">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="2Me_IsoCit_deHydtase_PrpD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036148">
        <property type="entry name" value="MmgE/PrpD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042183">
        <property type="entry name" value="MmgE/PrpD_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042188">
        <property type="entry name" value="MmgE/PrpD_sf_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005656">
        <property type="entry name" value="MmgE_PrpD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045337">
        <property type="entry name" value="MmgE_PrpD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045336">
        <property type="entry name" value="MmgE_PrpD_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006943">
        <property type="entry name" value="PRK09425.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02330">
        <property type="entry name" value="prpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16943">
        <property type="entry name" value="2-METHYLCITRATE DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16943:SF16">
        <property type="entry name" value="2-METHYLCITRATE DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19305">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MmgE_PrpD_N"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF103378">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="18"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="MmgE/PrpD C-terminal" evidence="4">
        <location>
            <begin position="283"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF19305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PCH43772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="480" mass="53176" checksum="C12646B53481FA1E" modified="2018-01-31" version="1">MSSHAESAVRPEPDQVLQDIADYVHNYKINSESAWETARLCLIDTIGCGLEGLRFEACARLLGPVVEGTIVPNGTRVPGTNYQLDPIRGAFNIGTQIRWLDFNDCFLAAEWGHPSDNLGAILAVADHLARKGEPLTVRDVLEGMVKAHEIQGGLALLNSFNRVGLDHVVLVKVASTAVVSKLIGLDRAQTIDAISQAWADGQSLRTYRHAPNTGSRKSWAAGDACARAVNIAYLVKKGEKGMPSVLTAKTWGFYDVLFKGKPFEFQMPFSSYIMENVLFKISYPAEFHAQTAVEAAHIIYGKLKAMGKTSNDIKSIRIRTQEAAMRIINKRGPLDNFADRDHDINYMVAYPLIFGELTSESYTDAAAADPRIDALRAKITCVEEKVYSVDYHDPAKRSISNALLVELNDGTVLDEVEVQYPVGHKRRRAEGTPLLLQKFKNHISPHFGQVHQKKILDIVNDSATLFQLPVDKFTDLFVKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JP32</accession>
    <name>A0A2H3JP32_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_153308</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468135">
        <property type="protein sequence ID" value="PCH43255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JP32"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH43255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="119" mass="13468" checksum="1D52858A210D176D" modified="2018-01-31" version="1">MVLTFQSVSPNGQAEVAAFISTLGPEHTVRQYATSPFLECRVRKRFHWVAKQAANLGWFSCLLISPSGTPRTRSIHVFRSGFWEEIDDGKDIEDIDTMFKTMAVQDCPAQLFPCPRKSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JP57</accession>
    <name>A0A2H3JP57_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_142254</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH37797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JP57"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="224"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH37797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="256" mass="28358" checksum="C167D58D18996525" modified="2018-01-31" version="1" fragment="single">MHIPYQHWISQIDLVLLVLQGLTVLALAFTSALASKLAFHVTTSGAHPSVSDSAMSIVTVNMDVVLAALFAESMLGHAWMRCALTINSGMSDVTSVSCISDILYGAALAFALLLTIRVCASVRHTWSNGLSWLTYRPLGLVILRKKWLLSAICHFGILDTPHCNAAVYTAEATHRSLLSEQSTYEQAYESTVVDASQLAGQTLVDQHEDAKPPRGDEIRLGDIMRMIQKDRKERRARRREQEEELARVVQEKIELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JPR0</accession>
    <name>A0A2H3JPR0_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Origin recognition complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WOLCODRAFT_104689</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">ORC is composed of six subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ORC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468157">
        <property type="protein sequence ID" value="PCH44162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JPR0"/>
    <dbReference type="STRING" id="742152.A0A2H3JPR0"/>
    <dbReference type="OMA" id="CSFHERL"/>
    <dbReference type="OrthoDB" id="1926878at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
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            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="345" mass="37856" checksum="5EAE8ACF5CF80CF6" modified="2018-01-31" version="1">MLSPAAETYGPIFVGCVLNILLYGIMITQTFLYFTVYKRDKLWMKLFVGLLFLCDTLNCAFDIAFTYMPLVNGFGNIPGLNQATWVFGTDPAMTAIIALLVQMFFAWRVKILTGSVPATCFIMFCSFCQWCGGLGTSIAVGMFPEFTHFQRFEVIVIIWLAFSAVADSAITAALVWHLRKHKTGFSQTDDIVNKIIRLTVQTGLVTALCAIIDLILFLASPSGLHLIFNLPLSKLYTNSLMSSLNSRAGWKYGNVGAGTHMSEISRSNMKGLSVHSEIGKRFSQAGQEVFIDVESHEMIDAIDKAPLPSPSDTSTLKMHPVPSRSSGDKSARLSVGQAPPRPTSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JQR7</accession>
    <name>A0A2H3JQR7_WOLCO</name>
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        <submittedName>
            <fullName evidence="15">Multidrug resistance-associated ABC transporter</fullName>
        </submittedName>
    </protein>
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        <name evidence="15" type="ORF">WOLCODRAFT_154316</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="PCH44281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="6500128at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042592">
        <property type="term" value="P:homeostatic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18595">
        <property type="entry name" value="ABC_6TM_MRP1_2_3_6_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18603">
        <property type="entry name" value="ABC_6TM_MRP1_2_3_6_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000450">
        <property type="entry name" value="ABC transporter C family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000001">
        <property type="entry name" value="ATP-binding cassette subfamily C member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000074">
        <property type="entry name" value="Multidrug resistance-associated protein 5 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000078">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.1, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056227">
        <property type="entry name" value="TMD0_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF443">
        <property type="entry name" value="MULTIDRUG-RESISTANCE LIKE PROTEIN 1, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24357">
        <property type="entry name" value="TMD0_ABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="318"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="391"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="418"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="503"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="536"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="964"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1051"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1152"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="270"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="603"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="924"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="1245"/>
            <end position="1478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PCH44281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="1483" mass="163608" checksum="1A9FF5096FD1593A" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JR40</accession>
    <name>A0A2H3JR40_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WOLCODRAFT_71822</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD-104</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JR40"/>
    <dbReference type="STRING" id="742152.A0A2H3JR40"/>
    <dbReference type="OMA" id="HVVNLCG"/>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0085020">
        <property type="term" value="P:protein K6-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF8">
        <property type="entry name" value="BRCA1-ASSOCIATED RING DOMAIN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="32"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="97"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PCH42363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="160" mass="17338" checksum="15FEFD59E45DE19D" modified="2018-01-31" version="1">MSTERTIKESPLCTISTSVCPILRSFDDPIRHYAASKSRVDTGRLLVSRGADINARDNANQLSLHRAATTGSVGFINLLLNPPEGSPKTRLNTADRVGNTPLHLAMESAHAEAACLLVEAGADRTRENLDGEMPEDLEGVGGQEQRRARAYVIERCGKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JRM3</accession>
    <name>A0A2H3JRM3_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_136386</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH38657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JRM3"/>
    <dbReference type="STRING" id="742152.A0A2H3JRM3"/>
    <dbReference type="OMA" id="ACKMAAM"/>
    <dbReference type="OrthoDB" id="19657at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050471">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433:SF5">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433">
        <property type="entry name" value="HYDROLASE, ALPHA/BETA FOLD FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="60"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH38657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="344" mass="37482" checksum="12DDE41A71332EAB" modified="2018-01-31" version="1">MSDTVPVNSDSDVASIPTIFDPATCTRKGLCPVTQLRHDGSPLSSHSLYFEQHGTGPEKIVFIMGLNSTSFSWFPQVDHFGRRPEYSILVFDNRGVGNSGVPRGPYTTSAMAEDVVTLLDYVGWTAERDLHVVGVSLGGMIALELATRIPNRIVSLTLAVTRAKRDVRASLPSLKGVSSLARLLGMSDPEAKIPVVLDMVFPRAWLDAPAENDAQGRTNREVQTIEYRKRFEASRPQSPFGALSQMAAGLTHGVSPARLRSISSSIPKVLIVTGDDDYLVDPANSRHMKACMPEAELVEWAGVGHAVQVQRREKFNELVERVIGEGRSKLTDGWKSAEVEGGQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JRR9</accession>
    <name>A0A2H3JRR9_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="5">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WOLCODRAFT_27109</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="5">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="5"/>
    <dbReference type="EMBL" id="KB468168">
        <property type="protein sequence ID" value="PCH44860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JRR9"/>
    <dbReference type="STRING" id="742152.A0A2H3JRR9"/>
    <dbReference type="OMA" id="REAMTAC"/>
    <dbReference type="OrthoDB" id="193716at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="149"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="392"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="49"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="666"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="49"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="689"/>
            <end position="700"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
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        </source>
    </evidence>
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</entry>
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            <taxon>Phaeolaceae</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
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                <person name="Eastwood D.C."/>
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        </source>
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        <source>
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        </source>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Martinez A.T."/>
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                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
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                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
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                <person name="Wiebenga A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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    <feature type="transmembrane region" description="Helical" evidence="11">
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        </source>
    </evidence>
    <sequence length="370" mass="40070" checksum="C46A7E1AB86F5E8C" modified="2018-01-31" version="1">MPTSQPTQLTPFGYALAGALGGCFSNAVVYPLDVAKTRIQAATSASLNGSEKDKEKLSVVAVLLRILKEEGIPGYYRGFTATMINTFSMQYAYFFFYSFVRTSYIKRLAARLPAGVKAPPLSTAAELILGAVAGALAQIFTIPVSVIATRQQIGPSLDRRASRAGSRVRRDGEDIEKTAGKETDGYDDSFLGIAREIIEEEGPGGLWLGLRPGLVLTVNPAITYGAYERVKSVLVLAQEAAGRGSKLSPWTAFLVGALSKTLATVVTYPYIMAKVRIQARSADTEEAVAEHQPAPPKHAYHHAHSKHVGALGILARVWRQEGFLGWYQGMGAQITKAVLSQALLFMSKDQFESWALAIMVLCWRLGRAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JTY9</accession>
    <name>A0A2H3JTY9_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acetyl-CoA synthetase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WOLCODRAFT_132347</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468124">
        <property type="protein sequence ID" value="PCH42369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JTY9"/>
    <dbReference type="STRING" id="742152.A0A2H3JTY9"/>
    <dbReference type="OMA" id="VRICTET"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051414">
        <property type="entry name" value="Adenylate-forming_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439:SF2">
        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439">
        <property type="entry name" value="PHENYLACETATE-COENZYME A LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23562">
        <property type="entry name" value="AMP-binding_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="23"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="Thioester reductase (TE)" evidence="4">
        <location>
            <begin position="643"/>
            <end position="884"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PCH42369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="961" mass="106494" checksum="B58E464F00617213" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JU12</accession>
    <name>A0A2H3JU12_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">18S rRNA factor 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WOLCODRAFT_131842</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ESF2/ABP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH41318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JU12"/>
    <dbReference type="STRING" id="742152.A0A2H3JU12"/>
    <dbReference type="OMA" id="ILAIPHC"/>
    <dbReference type="OrthoDB" id="287393at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034462">
        <property type="term" value="P:small-subunit processome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12263">
        <property type="entry name" value="RRM_ABT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039119">
        <property type="entry name" value="ABT1/Esf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034353">
        <property type="entry name" value="ABT1/ESF2_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12311">
        <property type="entry name" value="ACTIVATOR OF BASAL TRANSCRIPTION 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12311:SF7">
        <property type="entry name" value="ACTIVATOR OF BASAL TRANSCRIPTION 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="181"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="194"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PCH41318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="250" mass="28557" checksum="0AE7A00101E642E2" modified="2018-01-31" version="1">MDPEGFAGPSSKVVKPLTAEALAAFKAAQEKTGVIYISRIPPGMRPTKVRHIMSTYGEVGRVYLQQEDPKRAYLRRKYTATKKVHFTEGWVEFKDKRVARSVAEMLNAQPIGGKKGTRWRDDVWTMKYLPKFKWNMLTEQIAHEAAVHAAKLRAELSQSRREQHEYLKNVELARVLNKRAERKRKAGTEASADAEGKPSRRADDLGKANDPDKTNKERAREDKPRKKQKHIPGPDSNTEKQLDNVLHSIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JU90</accession>
    <name>A0A2H3JU90_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mei2-like C-terminal RNA recognition motif domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WOLCODRAFT_122132</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
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        </citation>
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            <strain evidence="4 5">MD-104</strain>
        </source>
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            <begin position="881"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
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    </evidence>
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            <dbReference type="EMBL" id="PCH43533.1"/>
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</entry>
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            <fullName evidence="4">phosphoinositide 5-phosphatase</fullName>
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        <name evidence="11" type="ORF">WOLCODRAFT_24751</name>
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        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
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                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD-104</strain>
        </source>
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        <subcellularLocation>
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        </subcellularLocation>
    </comment>
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    </comment>
    <comment type="similarity">
        <text evidence="3">In the central section; belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family.</text>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Inositol polyphosphate 5-phosphatase"/>
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    </dbReference>
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        <property type="entry name" value="IP5"/>
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        <property type="entry name" value="IPPc"/>
    </dbReference>
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        <property type="entry name" value="SAC_dom"/>
    </dbReference>
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        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200:SF257">
        <property type="entry name" value="PHOSPHOINOSITIDE 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
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    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
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    <feature type="domain" description="SAC" evidence="10">
        <location>
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            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
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    </feature>
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        <location>
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            <end position="980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
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        </location>
    </feature>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH41458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="1035" mass="115196" checksum="1D9132E1A010C991" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JW10</accession>
    <name>A0A2H3JW10_WOLCO</name>
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        <recommendedName>
            <fullName evidence="4">Mitotic-spindle organizing protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Mitotic-spindle organizing protein associated with a ring of gamma-tubulin 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WOLCODRAFT_76836</name>
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    <organism evidence="8 9">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for gamma-tubulin complex recruitment to the microtubule organizing center (MTOC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MOZART1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468157">
        <property type="protein sequence ID" value="PCH44173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JW10"/>
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        </source>
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        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="74" mass="8103" checksum="160FDE1C2EB9770D" modified="2018-01-31" version="1">MSSRDSDRITSAQQTLDILYDISQLLNTQLDKETLATCVSMIESGVNPEALAAVVQELRRENQALNTHSPASGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JWE5</accession>
    <name>A0A2H3JWE5_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Glutamine synthetase</fullName>
            <ecNumber evidence="4 13">6.3.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">WOLCODRAFT_69504</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 13">
            <text>L-glutamate + NH4(+) + ATP = L-glutamine + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16169"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.1.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homooctamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11 12">Belongs to the glutamine synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.2" evidence="4 13"/>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH41044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-EC"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Glutamine synthetase/guanido kinase, catalytic domain"/>
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    </dbReference>
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        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
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        <property type="entry name" value="Gln_synt_N_sf"/>
    </dbReference>
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        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
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    </dbReference>
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        <property type="entry name" value="Gln_synth_gly_rich_site"/>
    </dbReference>
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        <property type="entry name" value="Gln_synth_N_conserv_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050292">
        <property type="entry name" value="Glutamine_Synthetase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20852">
        <property type="entry name" value="GLUTAMINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20852:SF57">
        <property type="entry name" value="GLUTAMINE SYNTHETASE 2 CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
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    </dbReference>
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        <property type="entry name" value="Gln-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glutamine synthetase, N-terminal domain"/>
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    </dbReference>
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        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00180">
        <property type="entry name" value="GLNA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00181">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51986">
        <property type="entry name" value="GS_BETA_GRASP"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="8 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GS beta-grasp" evidence="14">
        <location>
            <begin position="21"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="GS catalytic" evidence="15">
        <location>
            <begin position="107"/>
            <end position="353"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51986"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PCH41044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="353" mass="39186" checksum="DD6624E8F50F9F34" modified="2018-01-31" version="1">MSSYRPDLLAPYLALPQGDKVQAEYVWIDGDGGLRSKTTTVTKKVTDIGQLRIWDFDGSSTNQAPGTDSDIYLRPAAIFKDPFRGGDNILVLAECYNNDGTPNRTNYRHHAKKVMDAAKDQVPWFGLEQEYTLFDMDGTPYGWPKGGFPGPQGPYYCGAGAGKVFARDLIEAHYRACLYAGVNISGINAEVMPSQWEFQVGPCEGISMGDHLWMARYLLIRIAEQWGIKVSFHPKPLSGDWNGAGCHTNYSTKAMREPGGMKYIEEAIEKLSKRHQEHIAVYGEDNDLRLTGRHETGHIGTFSSGVANRGASIRIPRHVGAQGYGYLEDRRPASNIDPYRVTAIIVETTCLDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JWV4</accession>
    <name>A0A2H3JWV4_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Endopolyphosphatase</fullName>
            <ecNumber evidence="3">3.6.1.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">WOLCODRAFT_24565</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the endopolyphosphatase PPN1 family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.10" evidence="3"/>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH41204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JWV4"/>
    <dbReference type="STRING" id="742152.A0A2H3JWV4"/>
    <dbReference type="OMA" id="LRFQDTI"/>
    <dbReference type="OrthoDB" id="348678at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000298">
        <property type="term" value="F:endopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004309">
        <property type="term" value="F:exopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006798">
        <property type="term" value="P:polyphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00842">
        <property type="entry name" value="MPP_ASMase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041805">
        <property type="entry name" value="ASMase/PPN1_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012358">
        <property type="entry name" value="EndopolyPtase_N1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340:SF55">
        <property type="entry name" value="ENDOPOLYPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340">
        <property type="entry name" value="SPHINGOMYELIN PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF027093">
        <property type="entry name" value="EndopolyPtase_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0926">Vacuole</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013689041" description="Endopolyphosphatase" evidence="13">
        <location>
            <begin position="23"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="14">
        <location>
            <begin position="42"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="54"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PCH41204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="549" mass="62963" checksum="F187E89C1089C210" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JX12</accession>
    <name>A0A2H3JX12_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sodium/calcium exchanger membrane region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WOLCODRAFT_73267</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468124">
        <property type="protein sequence ID" value="PCH42398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JX12"/>
    <dbReference type="STRING" id="742152.A0A2H3JX12"/>
    <dbReference type="OMA" id="ISVHTMG"/>
    <dbReference type="OrthoDB" id="1699231at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF20">
        <property type="entry name" value="CA(2+)_H(+) EXCHANGER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="325"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="362"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="395"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="456"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="40"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="330"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PCH42398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="485" mass="52495" checksum="A366C7E24663E611" modified="2018-01-31" version="1">MRPACMLAMIPLVKLHDLAISVMSRRIGGSKTGLLNASFVLELVVAIIALRKCELRVVQSSLVGSILSKLLLILGMCFFAGGMRFSQQDFNTTATQIHSSLLSISVGAVCLPAAFHFALSYNTQDATAIGTTMDQQKADLLKMSHSVSLLLSLYISYLLFQLWSHTHLYEDSTVPSDKLPVAVSMRSMTERVRQKSNSLRSRRSHSQASSFRSAYSKQTLALTIDDRIAKLKEKERTSPVEEAPETSFSHFGAHALRAASGSPDGASARGRTALLLSPSGTASQVRLSAGEFGERADADATIPRSVSASATQRAASPQEEEEPELSWITILILLTIVTLVTINSEWLVDSMDSLSPTLSKEWIGLILLPIVSSIAECVTAVNVSVKDQLTLSISVAVGSTIQTALFVIPLMVILGWILDKPLALLFDPFETVVPAFAVHIMGNVVADGKSNWLEGVILICLYLVIAVTFWFYPGVSILLLASRAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JX66</accession>
    <name>A0A2H3JX66_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycolipid transfer protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_139078</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
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            <strain evidence="3 4">MD-104</strain>
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                <person name="Barry K."/>
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                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
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                <person name="Benoit I."/>
                <person name="Boyd A."/>
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                <person name="Ferreira P."/>
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                <person name="Kallen N."/>
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                <person name="Nagy L.G."/>
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                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        <location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="214" mass="23168" checksum="CFD3DF57AB01821A" modified="2018-01-31" version="1">MIGSNNSRPSSCACEWPKHPLHATASCQTPSRAPEDGTRGNDVRSVARPHTPTRSLRPRARRSSHLAATRTTLHTPTCMPAPCPSTLPRPQINGTVRNGNATDRLFTPDALMYPRAVPSRRSAHPDADSGESSPVQRYLYLYARTLARSRVRTPLPGKSTARTALGSGRPVGPPSIALIVQNSGAWPAAPRSCLVDTVQMHDVTSSRQRVRTVN</sequence>
</entry>
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                <person name="Otillar R."/>
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                <person name="Yadav J.S."/>
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                <person name="Ferreira P."/>
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                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">MD-104</strain>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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    </evidence>
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</entry>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Barry K."/>
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                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
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                <person name="Patyshakuliyeva A."/>
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                <person name="Wiebenga A."/>
                <person name="Young D."/>
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                <person name="Eastwood D.C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
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    </reference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006598">
        <property type="term" value="P:polyamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050281">
        <property type="entry name" value="Flavin_monoamine_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742:SF313">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742">
        <property type="entry name" value="FLAVIN MONOAMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013554481" evidence="1">
        <location>
            <begin position="25"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="Amine oxidase" evidence="2">
        <location>
            <begin position="49"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH42978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="509" mass="56425" checksum="57EB9784F2D00564" modified="2018-01-31" version="1">MSLRGLLSWCSIGTLLLQNGHVYARSVLADRAVGVPVANASVLILGGGVAGVIAARTLYEQGITDFMIVEARDELGGRLQTETIGAPGNEWVVERGPNWVQGTQTGNGPENPIWALVKKHGVKTQYNDWYDSMTTYDESGYVNYTDTFNESGDGYDTLTVAAGARVAKKLVDMTARTGYSLIGAKPQTPADKACEYYQFDWEYAQTPEESSWIASSWGNNFTYDPDDGGFGDDNQMSIDQRGFKYFIQAEAAEFLQPEQVKYNATVTKIAYSSDGVDVTLASGEVLSADYVLCTFSVGVLQNDDVTFDPPLPAWKQEAIQGIVMATYTKIFLQFEEDFWFDTQMGLYADTTRGRYPVWQNMNLTDFFPGSGVVFVTVTGEYSVRVEALSDEEVKEEVLGVLKLMYPNVTIPEPTAFYFPRWHTNPLFRGSYSNWPSSFFNGHHENLRATVNQRLWFAGEATSLKYFGFLHGAYFEGLDVGTTLANCIWAGGCAGMAHVPEVTNAYPYKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K018</accession>
    <name>A0A2H3K018_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Lytic polysaccharide monooxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">WOLCODRAFT_137865</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MD-104</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the polysaccharide monooxygenase AA14 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468124">
        <property type="protein sequence ID" value="PCH42354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K018"/>
    <dbReference type="STRING" id="742152.A0A2H3K018"/>
    <dbReference type="OMA" id="ARPHPWS"/>
    <dbReference type="OrthoDB" id="2019572at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054497">
        <property type="entry name" value="LPMO_AA14"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22810">
        <property type="entry name" value="LPMO_AA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0186">Copper</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013857303" description="Lytic polysaccharide monooxygenase" evidence="13">
        <location>
            <begin position="21"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="297"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="310"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="361"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00046340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PCH42354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="376" mass="40693" checksum="345E441EF8F27E91" modified="2018-01-31" version="1">MIHAAPALLSLAALAPLASAHIAFWDKSMYGFNVTQQTFSYDNRPVTPLIEYTFDQWWFHGHLDYPPNPGDTFELPVGQAVNTQLSCDKGATSWWPSSQGGDAGYGSNWPCPGQPSTQFHTLSIDDVYGCALAIAYKPDANDVQPDDFVIFSVNQTCVWYLNTAFQVPQDMPACPEGGCTCAWTWIHSDNSGAEQLYMNGFHCDITGATSTTPIGKPMLPRRCGADPTQNQEANPGNCTIGPKYMMYWLQAEGNNMFEGYYMPPHYNDVYGFHDGAQNDIFQDAYISSLGPSSTAAARREDVPVAPPTAVPSAPSVPVSAPAVPTSVPSVPTGVSAPSSIPASIPTGSTESVLPGDVHKEKVLKRHRRKGSHEGHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K0A5</accession>
    <name>A0A2H3K0A5_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATP-dependent DNA helicase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_75077</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468146">
        <property type="protein sequence ID" value="PCH43538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K0A5"/>
    <dbReference type="STRING" id="742152.A0A2H3K0A5"/>
    <dbReference type="OMA" id="TRCVFSH"/>
    <dbReference type="OrthoDB" id="3353471at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005657">
        <property type="term" value="C:replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18809">
        <property type="entry name" value="SF1_C_RecD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23274">
        <property type="entry name" value="DNA HELICASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23274:SF51">
        <property type="entry name" value="OS03G0423850 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH43538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="106" mass="11870" checksum="9B90ED7D284E6CAE" modified="2018-01-31" version="1">MRGAAGVSIVDPDEIVLSRIVFQVPLETGHTLVRRQFPLAPAYATTFNSCQGLTLDTVGVDLTRCVFSHGQLYTALSRIRHRKDARVRLPFGRELTKNVTYNEILI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K1R6</accession>
    <name>A0A2H3K1R6_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_121305</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="PCH42974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K1R6"/>
    <dbReference type="STRING" id="742152.A0A2H3K1R6"/>
    <dbReference type="OMA" id="ISCWAIM"/>
    <dbReference type="OrthoDB" id="3263941at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH42974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="132" mass="14446" checksum="43B9106CBD576D9B" modified="2018-01-31" version="1">MRKTFAVWLIMGFVYLMCWTLMFSSSSFRWTFLYWEFFACLTCTTYVALIATGIAGIICRVNFGKGLAHYLHVEEALTKSGFAVGLFSNETEQPRPPKTSAATGITGTADEKHYGKGGQSDVGTGIQGSSAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K3B6</accession>
    <name>A0A2H3K3B6_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Acid protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WOLCODRAFT_138418</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase A1 family.</text>
    </comment>
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        <property type="protein sequence ID" value="PCH43534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="742152.A0A2H3K3B6"/>
    <dbReference type="OMA" id="FHINGHA"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000115">
        <property type="entry name" value="Lysosomal aspartic protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF57">
        <property type="entry name" value="PEPTIDASE A1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6 10" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013736224" evidence="8">
        <location>
            <begin position="25"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="467"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="9">
        <location>
            <begin position="93"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PCH43534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="489" mass="50989" checksum="BF906E8ACA6AECD8" modified="2018-01-31" version="1">MTMRLLPWLLTVTCLLFCAREAIAAPPRPYAFNGKSMCLSRRSNRLRSVEEVGPMVRRHKLAVEAKYGIGHAKNQKRASGMNLITNQGADASYFGSLAVGTPPVSFDVILDTGSSDLWIAAGGTTADIPSGICTFSPSSSSSFRDLNTTFLIEYGSGAAEGSLAEDTVQMAGFKVASQVFAVVDEVSDGALSAPVSGLMGLGWQQISSSGATPFWEALAETNDTLTEPLFAFQLTRYSNASEVWSLEPGGTFTLGATNASLYKGDIDYQDIPSGQVGYWMQEISAITVNGNSISLASGSSYAAIDTGTTLLGGPQAIIAEIYAQIPGSEAGTGDLDGYYLYPCDSPATVTLKFGSSSIAWPISTTDFQYMSASSDGNMCIGSLHVIDNAGTTAPPWVIGDTFLKNVYSVFRYDPPSVGFAVLSETALKMNGATGSAPSPTIGSVAASLSAIPTRVNTDRSNSGSATFGYGAGTSFLTCAAVAVAAAFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K3I3</accession>
    <name>A0A2H3K3I3_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_165341</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468168">
        <property type="protein sequence ID" value="PCH44708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K3I3"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH44708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="318" mass="35189" checksum="67917A5D76C751C2" modified="2018-01-31" version="1">MWQCSLRLLGKLKGTREFLVDLNGGRIDLVPDDMQGQLPALLEGVEILSLSGIVCLGGPPALQGILLACSRLSHLYLNGVCFADDVSPYHLHDATANHKETLRTFVYYGDDDDPSEQELLRWLAHGGMNFRPSRLGFTTMTEGICDMLHSAGDSLEYLWVDLSEPIFPPMAPALACNTRLASIDILYFNPRLIAAWRVLSVLSSIGATNTSMQQLGLSVIGPLAKLVNASTWREVDSHLARLARSLPALVVTFYFHRCFNDDDQRGKIIEILDNFMLYREARGRLAVCWSATPEQYAKAVDLKLVCQPELDPGLLGSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K3T1</accession>
    <name>A0A2H3K3T1_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glycosyltransferase family 2 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WOLCODRAFT_121473</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB468135">
        <property type="protein sequence ID" value="PCH43077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K3T1"/>
    <dbReference type="STRING" id="742152.A0A2H3K3T1"/>
    <dbReference type="OrthoDB" id="9876900at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050501">
        <property type="term" value="F:hyaluronan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0085029">
        <property type="term" value="P:extracellular matrix assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030213">
        <property type="term" value="P:hyaluronan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22913">
        <property type="entry name" value="HYALURONAN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22913:SF12">
        <property type="entry name" value="MANNURONAN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03142">
        <property type="entry name" value="Chitin_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="259"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="332"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="391"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="427"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="391"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PCH43077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="450" mass="50813" checksum="DE8BC0D5B1D20462" modified="2018-01-31" version="1" fragment="single">MFTAFMVGAYALGTKDAMLTTDSDTYVYPDAVKNMMALLFSDCRLAGVTGDVRIWNKSDSFLALMSSIRYWFAFNVERACQSAFGCVGCLSGPLGLYKTSDLISVLSPWILQSFLGKETTFGDDRHLSNRILSLGHKTGYTHLAMCDSDTPAGYVRWVKQQTRWSKSFFREAFWFPKSFAYHRFVSIASWSRYCWLTVETTKQFLYPMVLTATVLQMLYRPSSWIRPLIWLATMFGVALIKSIYGVVCLRDPRQFLFGIYGFMYFFGLLPSKLFACFTVHITNWGTSARSKSEFARPESFLSRTTHVGHLVVWYLMLSVGLSYLLATVFHQPFFWLVSILGVALSGQAYSDVIIGESKYAMYMIKKKWKARRAAKAGIEDVEKVAGKTKQRRGLKFRRNKKRADKEKAALSSEIPPVAEIEEIVTPSASVDVPSTDDTDAHAGPSVLPSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K5Y6</accession>
    <name>A0A2H3K5Y6_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP-dependent DNA ligase family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WOLCODRAFT_105197</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468157">
        <property type="protein sequence ID" value="PCH44474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K5Y6"/>
    <dbReference type="STRING" id="742152.A0A2H3K5Y6"/>
    <dbReference type="OMA" id="RIDEFWR"/>
    <dbReference type="OrthoDB" id="7482721at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032807">
        <property type="term" value="C:DNA ligase IV complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006297">
        <property type="term" value="P:nucleotide-excision repair, DNA gap filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3260.10">
        <property type="entry name" value="DNA ligase, ATP-dependent, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016059">
        <property type="entry name" value="DNA_ligase_ATP-dep_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012308">
        <property type="entry name" value="DNA_ligase_ATP-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029710">
        <property type="entry name" value="LIG4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45997:SF2">
        <property type="entry name" value="ATP DEPENDENT DNA LIGASE DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G02430)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45997">
        <property type="entry name" value="DNA LIGASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04675">
        <property type="entry name" value="DNA_ligase_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00697">
        <property type="entry name" value="DNA_LIGASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00333">
        <property type="entry name" value="DNA_LIGASE_A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-dependent DNA ligase family profile" evidence="7">
        <location>
            <begin position="438"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="817"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="817"/>
            <end position="827"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PCH44474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="1042" mass="117095" checksum="029416B8F97DE68C" modified="2018-01-31" version="1"> </sequence>
</entry>
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                <person name="Barry K."/>
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    </evidence>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
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                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
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                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
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                <person name="Wiebenga A."/>
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        <reaction evidence="1 13">
            <text>D-ribulose 5-phosphate = D-xylulose 5-phosphate</text>
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            <dbReference type="ChEBI" id="CHEBI:58121"/>
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        <cofactor evidence="4">
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    </dbReference>
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        <location>
            <position position="34"/>
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        <ligand>
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            <position position="36"/>
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        <ligand>
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        <ligand>
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        <location>
            <position position="174"/>
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        <ligand>
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        </ligand>
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    <feature type="binding site" evidence="16">
        <location>
            <position position="176"/>
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        <ligand>
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        <location>
            <begin position="196"/>
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        </location>
        <ligand>
            <name>substrate</name>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-05-03" version="8" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
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                <person name="Kuo A."/>
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                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
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                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
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                <person name="Murat C."/>
                <person name="Nagy L.G."/>
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                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
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                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
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                <person name="Pisabarro A."/>
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        </source>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
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                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="195" mass="21335" checksum="C13598A7FB7FC6D9" modified="2018-01-31" version="1">MTPILLSAKYDGHLEVKHLTRFAGPCTWAANTSGSASRVKPINSIPHRLQPREFTAIWGGSDIGIELAGKPKTVLVHDGSGQRRVPDKCHVFGYPGSREQETDAAPRLVEDTRTSIAERMYAFSRTFGPASKCRLDIRLPADMRHTELSRPATARGANTTIASHGNQDQVQGAIPNGESSFHPRPTTLLLIIDRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IZK1</accession>
    <name>A0A2H3IZK1_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Essential protein Yae1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WOLCODRAFT_78724</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LTO1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467832">
        <property type="protein sequence ID" value="PCH34865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3IZK1"/>
    <dbReference type="STRING" id="742152.A0A2H3IZK1"/>
    <dbReference type="OMA" id="YQLGYAQ"/>
    <dbReference type="OrthoDB" id="48036at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019191">
        <property type="entry name" value="Essential_protein_Yae1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052436">
        <property type="entry name" value="LTO1_adapter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28532">
        <property type="entry name" value="GEO13458P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28532:SF1">
        <property type="entry name" value="ORAL CANCER OVEREXPRESSED 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09811">
        <property type="entry name" value="Yae1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Essential protein Yae1 N-terminal" evidence="3">
        <location>
            <begin position="5"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="115"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PCH34865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="159" mass="17824" checksum="3B1198A83319FBFB" modified="2018-01-31" version="1" fragment="single">FYDAGYEDGFSHGRIHGSIEGRALGREKGFEMWEEVGFYQGFAMMWQEIHTIQGLSDDRIAHHIRHLLDLIAQFPQTNPSVVEPSDLDIPRLFRQIRSRYKALCATLGVRPTLRAGGSSTPAQELDPADSAEVPRQGGSRNVWPVQSADKAPTKEELSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J031</accession>
    <name>A0A2H3J031_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_139973</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467854">
        <property type="protein sequence ID" value="PCH35600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J031"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH35600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="81" mass="8641" checksum="BD731083D7072F39" modified="2018-01-31" version="1">MDTLHRVHQRRARRGCRACCTGHTYGGAAQRKVRLAAQGRRVSGRAGPAAGRPTPASAGPAAYDVDGRGSTWHPSRVFRCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J0D7</accession>
    <name>A0A2H3J0D7_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WOLCODRAFT_28083</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467854">
        <property type="protein sequence ID" value="PCH35710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J0D7"/>
    <dbReference type="STRING" id="742152.A0A2H3J0D7"/>
    <dbReference type="OMA" id="KDWYKGG"/>
    <dbReference type="OrthoDB" id="204711at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005469">
        <property type="term" value="F:succinate:fumarate antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000021">
        <property type="entry name" value="SFC1p Mitochondrial succinate-fumarate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049563">
        <property type="entry name" value="TXTP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788">
        <property type="entry name" value="SUCCINATE/FUMARATE MITOCHONDRIAL TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788:SF2">
        <property type="entry name" value="SUCCINATE_FUMARATE MITOCHONDRIAL TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="10"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="112"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="214"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PCH35710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="318" mass="34606" checksum="3B2A5B9711893619" modified="2018-01-31" version="1">MSRNGDRKPAGFATQLTAGGIAGAMEALCCQPLDTIKVRMQLSRSGRAPGTKPRGFLATGALIVRRETPLALYKGLGAVLSGIVPKMAIRFASFESYRAWLADKETGKTSVGNIFIAGLGAGTTEAVFVVTPMEVVKIRLQAQQHSLADPLEIPQYRNAGHAVYKIIREEGFSTLYRGVTLTALRQATNQGANFTAYQELKKFAHRLQPELEDLPSYQHMVIGLISGAMGPFSNAPIDTIKTRLQKATTVPGTSAFQRIAAIAGDMWREEGFRSFYKGITPRVLRVAPGQAIVFAVYERVRKGMETMQGSSEAKTYSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J190</accession>
    <name>A0A2H3J190_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_145820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467854">
        <property type="protein sequence ID" value="PCH35455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J190"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6534" evidence="1">
        <location>
            <begin position="51"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH35455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="172" mass="19010" checksum="2B74213A43591504" modified="2018-01-31" version="1">MVAASGLLGLFTFPVWDQIYRWLSATWESFLSINSNSDLLISQLSTLLADDLLLPAILCYVLHGYENGFTSFKQLNNTEDMISKLVMFALERGVLMCAMDIGILVNVLNDRDNGTATGYIVWVNSVLASLNARRYLRKLGTSSSQIQDTPLTTFRVSSSAPKELSEDIGISC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J1T8</accession>
    <name>A0A2H3J1T8_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Serine/threonine-protein kinase TOR</fullName>
            <ecNumber evidence="11">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">WOLCODRAFT_91904</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the PI3/PI4-kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="11"/>
    <dbReference type="EMBL" id="KB467876">
        <property type="protein sequence ID" value="PCH36202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="742152.A0A2H3J1T8"/>
    <dbReference type="OMA" id="MRQHSAK"/>
    <dbReference type="OrthoDB" id="381190at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016242">
        <property type="term" value="P:negative regulation of macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080090">
        <property type="term" value="P:regulation of primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038202">
        <property type="term" value="P:TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05169">
        <property type="entry name" value="PIKKc_TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000028">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.150:FF:000001">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000371">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000006">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.150">
        <property type="entry name" value="FKBP12-rapamycin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009076">
        <property type="entry name" value="FRB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036738">
        <property type="entry name" value="FRB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057564">
        <property type="entry name" value="HEAT_ATR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024585">
        <property type="entry name" value="mTOR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003151">
        <property type="entry name" value="PIK-rel_kinase_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026683">
        <property type="entry name" value="TOR_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF9">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02259">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02260">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08771">
        <property type="entry name" value="FRB_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23593">
        <property type="entry name" value="HEAT_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11865">
        <property type="entry name" value="mTOR_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13176">
        <property type="entry name" value="TPR_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01346">
        <property type="entry name" value="DUF3385"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01345">
        <property type="entry name" value="Rapamycin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47212">
        <property type="entry name" value="FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6 11 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FAT" evidence="14">
        <location>
            <begin position="1251"/>
            <end position="1802"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="13">
        <location>
            <begin position="1976"/>
            <end position="2290"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="15">
        <location>
            <begin position="2324"/>
            <end position="2356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="800"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="809"/>
            <end position="821"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PCH36202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="2356" mass="267040" checksum="8813A4E3F3A909A4" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J2D9</accession>
    <name>A0A2H3J2D9_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">26S proteasome regulatory subunit 4 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WOLCODRAFT_28367</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the AAA ATPase family.</text>
    </comment>
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        <property type="protein sequence ID" value="PCH36151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19502">
        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000067">
        <property type="entry name" value="26S protease regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000007">
        <property type="entry name" value="26S proteasome regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="26S proteasome regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 13" id="KW-0647">Proteasome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="12">
        <location>
            <begin position="219"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00068880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PCH36151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="441" mass="49651" checksum="1B91219757FCD8EA" modified="2018-01-31" version="1">MSGRGNQQQQDGDKKDKQQQQKKWEPPLPTRVGKKKRKHGPDAASKLPAVHPTTRCRLRLLKMERIKDYLLMEEEFIQNQERLKPEATREEKDEEDRSKVDDLRGSPMAVGTLEEIIDDDHAIISTASGPEYYVSIYSIVDKDLLEPGCQVLLHSKNQAVIGVLQDDADPMVSVMKLDKAPTESYADIGGLEQQIQEIKESVELPLTHPELYEEMGIKPPKGVILYGVPGTGKTLLAKAVANQTSATFLRVVGSELIQKYLGDGPKLVRELFRVAEEYAPSIVFIDEIDAIGTKRYDSTSGGEREIQRTMLELLNQLDGFDTRGDVKVIMATNKIESLDPALIRPGRIDRKIEFPLPDIKTKRHIFKLHTSRMNLAEDVDLEDYITAKDDLSGADIKAVCTEAGLLALRERRMRVNKADFTSAREKVLYRKNEGTPEGLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J2I3</accession>
    <name>A0A2H3J2I3_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sec1-like snare protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_140387</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="PCH36391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="742152.A0A2H3J338"/>
    <dbReference type="OMA" id="GRYFQLK"/>
    <dbReference type="OrthoDB" id="2107885at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059112">
        <property type="entry name" value="CysZ/EI24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052786">
        <property type="entry name" value="Spore_wall_assembly"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34292">
        <property type="entry name" value="OUTER SPORE WALL PROTEIN LDS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34292:SF2">
        <property type="entry name" value="OUTER SPORE WALL PROTEIN LDS1"/>
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    </dbReference>
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    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="24"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="81"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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        </location>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PCH36391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="302" mass="32987" checksum="9C541EAAF8E5DBB3" modified="2018-01-31" version="1">MSEARLQSYIQNTAHALLDDGKHLLLFIAQGIASFAWLWPLQGVYFSVANPSLLLSVRPALLKALFSSILIFGALAFFTFLPQMAILVLVSGPFAPILALLLIGAETVLIFSFFARPLLLTSALAHVFDATLRARGQGELVKSGLTRTRSPRAAAQIEGALMKPFQALSSDGLLRYLATLPLNFVPLLGSAAFVLYNGYKSGASWHARYFQLKGWSKAQQQAFVDRRRAEYAAFGTMTLLFTFIPLVGLVFNFTNTVGAAMWAAQLEAQANLIDGAAELQPPEPDSSKKSDNRRNDDTNQES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J351</accession>
    <name>A0A2H3J351_WOLCO</name>
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            <fullName evidence="1">Uncharacterized protein</fullName>
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        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
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            <taxon>Phaeolaceae</taxon>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
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                <person name="Lindquist E."/>
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                <person name="Martin R."/>
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                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
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                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="742152.A0A2H3J351"/>
    <dbReference type="OrthoDB" id="2691032at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH36135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="233" mass="26198" checksum="88CA30D23F4C9012" modified="2018-01-31" version="1">MAPFDTIMWVHEVQHMIQEIQAWCIYVHHVKGRIDNPDFMDNMNVLPVRGVITLCAPVAALEPQVHDYPSDVMVSMPLSGVLPIAMVDPRKPNPFLVLDASPVPENQAGPPILQSPSRPTDFEDTLLTTLDSTEVQAEQFTSNNIPMETEREPTPLPEFIVNETMLETLHCTLRDSTGSLNVEQLEQLRATCLGCVWRHCSDWNRITLIKEPTPVVQEFAEEVLLDDMDGSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J3K2</accession>
    <name>A0A2H3J3K2_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">separase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WOLCODRAFT_95323</name>
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        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
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                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
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                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
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                <person name="Ruiz-Duenas F.J."/>
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                <person name="Eastwood D.C."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>All bonds known to be hydrolyzed by this endopeptidase have arginine in P1 and an acidic residue in P4. P6 is often occupied by an acidic residue or by a hydroxy-amino-acid residue, the phosphorylation of which enhances cleavage.</text>
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        </reaction>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051307">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Peptidase_C50"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12792">
        <property type="entry name" value="EXTRA SPINDLE POLES 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12792:SF0">
        <property type="entry name" value="SEPARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03568">
        <property type="entry name" value="Separin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51700">
        <property type="entry name" value="SEPARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C50" evidence="6">
        <location>
            <begin position="1970"/>
            <end position="2067"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
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            <begin position="378"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="979"/>
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        </location>
    </feature>
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        <location>
            <begin position="1231"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="381"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1244"/>
            <end position="1256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PCH34363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="2156" mass="239115" checksum="DBC9FA08CCD97305" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J4U8</accession>
    <name>A0A2H3J4U8_WOLCO</name>
    <protein>
        <recommendedName>
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        </recommendedName>
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    <organism evidence="16 17">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
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            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 12">Component of the cleavage factor I (CF I) involved in pre-mRNA 3'-end processing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the CPSF4/YTH1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH33769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J4U8"/>
    <dbReference type="STRING" id="742152.A0A2H3J4U8"/>
    <dbReference type="OMA" id="FHQNNFA"/>
    <dbReference type="OrthoDB" id="1914176at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000017">
        <property type="entry name" value="Cleavage and polyadenylation specificity factor 30 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045348">
        <property type="entry name" value="CPSF4/Yth1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23102:SF24">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23102">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14608">
        <property type="entry name" value="zf-CCCH_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18345">
        <property type="entry name" value="zf_CCCH_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 12" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="9 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 11 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 11 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="14">
        <location>
            <begin position="93"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="14">
        <location>
            <begin position="121"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="14">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="14">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="15">
        <location>
            <begin position="261"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="11">
        <location>
            <begin position="93"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="11">
        <location>
            <begin position="121"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="11">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="11">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="197"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="199"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU369008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PCH33769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="281" mass="31563" checksum="5FA84DBACA9CF032" modified="2018-01-31" version="1">MSLTTTATNPLAGPSALRDLVRPQFHQNNFAEELYVKSELGIKLDKDDQICRLSLTAAGCPLGPMHCPLRHTTPSTANFQPPKQLPTHPRERERLATVCKHWLRGLCKKGDACEFLHEYNLRRMPECWWYAKYGYCSAGDECLYAHPKERRIECPDYTRGFCKLGPACPRKHIRRVACQLYLTGFCPLGPDCPRGHPKPSIPPPEAYEPPPQPSIRDLGPPPPGYGRYADFDRNFPGPHPPGAGGSGGPPGPRRNLEDVVCFKCGEKGHYANHCRNQMRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J540</accession>
    <name>A0A2H3J540_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GroES-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WOLCODRAFT_92136</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD-104</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467898">
        <property type="protein sequence ID" value="PCH36785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J540"/>
    <dbReference type="STRING" id="742152.A0A2H3J540"/>
    <dbReference type="OMA" id="EPNLACG"/>
    <dbReference type="OrthoDB" id="3941538at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000721">
        <property type="term" value="F:(R,R)-butanediol dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034079">
        <property type="term" value="P:butanediol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08233">
        <property type="entry name" value="butanediol_DH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF23">
        <property type="entry name" value="(R,R)-BUTANEDIOL DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="6">
        <location>
            <begin position="8"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH36785.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="359" mass="37816" checksum="9DEE575E02231D26" modified="2018-01-31" version="1">MRAARYYGPGEMRVEDVPEPVVKEGQVKIKPLTYSDSPVCGSDVHSYFSLTPVSPTATMPHPVTKETLPITLGHEFSGTICELGPATDSSKLAIGQHVVVEPVISCMKPTCGPCSAGSRNICPNATFIGVGGGGGGLAEYITVQEDYVHVLPPTISLEVGAMMEPLSVAWHAVKRSTFVSGDTALIIGAGPIGLLILTVLRAHGASWIGISEPALSRRETALRLAATAVYDPRAVDVAAGTFRATSGGAAVVFDCAGTQASLDTALAAARPRGNVVEVAVWDKPPVLDITALQSKEVLLTASQACDREHPELIKAVADGRITGLEELITKRIDLGDFVEQGIKALIEDKDRQIKILVHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J5E5</accession>
    <name>A0A2H3J5E5_WOLCO</name>
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        <submittedName>
            <fullName evidence="14">NADPH oxidase isoform 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">WOLCODRAFT_29121</name>
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    <organism evidence="14 15">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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    </dbReference>
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        <property type="term" value="C:NADPH oxidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:monoatomic ion transport"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:superoxide anion generation"/>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Cyt_b245_heavy_chain"/>
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        <property type="entry name" value="FAD-bd_8"/>
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        <property type="entry name" value="FAD-bd_FR_type"/>
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        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
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        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
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        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
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        <property type="entry name" value="RBOH/FRE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972">
        <property type="entry name" value="NADPH OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972:SF153">
        <property type="entry name" value="SUPEROXIDE-GENERATING NADPH OXIDASE HEAVY CHAIN SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00466">
        <property type="entry name" value="GP91PHOX"/>
    </dbReference>
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        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NADPH_oxidase_subgroup_(NOX)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="176"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="213"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="255"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="293"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="13">
        <location>
            <begin position="309"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PCH37460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="608" mass="69701" checksum="50FABDD983FFD06E" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J5N6</accession>
    <name>A0A2H3J5N6_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SHSP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WOLCODRAFT_29156</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
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                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD-104</strain>
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    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
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    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
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        <property type="entry name" value="HSP20-like_chaperone"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SHSP" evidence="4">
        <location>
            <begin position="42"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="162"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PCH37516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="195" mass="21765" checksum="DB53C0FD95220914" modified="2018-01-31" version="1">MARLQQTPSNDEQRFRNLERTLARTFLRELLRRRSQPSAVSSPGRTYQPRMDLYDDPSYPWILATLELPGLKQEDISVRIEDNQLIVQGERRFANMGGGPHGPSPPDEHIVLVPGAAVSPMPRGYAVHEIKYGVFRREIGLPLGTQARHVQASLSEGMLKMSWPRNPQAEPFPTDRLTSGAEGADSGVSSLEHAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J696</accession>
    <name>A0A2H3J696_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">galacturonan 1,4-alpha-galacturonidase</fullName>
            <ecNumber evidence="13">3.2.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">WOLCODRAFT_177549</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Specific in hydrolyzing the terminal glycosidic bond of polygalacturonic acid and oligogalacturonates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[(1-&gt;4)-alpha-D-galacturonosyl](n) + H2O = alpha-D-galacturonate + [(1-&gt;4)-alpha-D-galacturonosyl](n-1)</text>
            <dbReference type="Rhea" id="RHEA:14117"/>
            <dbReference type="Rhea" id="RHEA-COMP:14570"/>
            <dbReference type="Rhea" id="RHEA-COMP:14572"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58658"/>
            <dbReference type="ChEBI" id="CHEBI:140523"/>
            <dbReference type="EC" id="3.2.1.67"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.67" evidence="13"/>
    <dbReference type="EMBL" id="KB467931">
        <property type="protein sequence ID" value="PCH37441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J696"/>
    <dbReference type="STRING" id="742152.A0A2H3J696"/>
    <dbReference type="OrthoDB" id="187139at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047911">
        <property type="term" value="F:galacturan 1,4-alpha-galacturonidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736:SF12">
        <property type="entry name" value="EXO-POLYGALACTURONASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 15" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013695690" description="galacturonan 1,4-alpha-galacturonidase" evidence="16">
        <location>
            <begin position="21"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PCH37441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="425" mass="46862" checksum="C28118FA7117F2E0" modified="2018-01-31" version="1">MSRVWCWLILLGLWLGQASAVTQNVGLQHNNTCVLKPLGRDQDDTDQIEAAIERCGHYGTTVFAEGVYNVTRTLQWDLVEARVDLHGYLNFTADLPYWMDPAHTVRVIFIQHQSSWFVLSGRDFIVDAHNTGGIIGNGQYWWDWYGTATRYGGDGRPVSLTVYRATRATIANFRIEGQPFWCNAIAESRDVVYDGMLCNATNTNPEYFGDNLVPNTDGIDTYRSDNITLLNWDMTTGDDCIAIKGNSTNIYARNITCRGGNGLAFGSLGQYFELFDHVENVTLEDTHVIRLDPQIQPNMRTGVYFKSWAGTRIGFPPSDGGGGLGLVKNVTVRNLRVDNATLPIQVIQRSNSLPGNAPSKLQFVNLTFVNVTGTATANTIVDIECSEAAPCPGLVFEDINVTVPSDESPAYICANVIAPQGLPSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J6E7</accession>
    <name>A0A2H3J6E7_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallo-dependent phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_130500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH37820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J6E7"/>
    <dbReference type="STRING" id="742152.A0A2H3J6E7"/>
    <dbReference type="OMA" id="HTPPYGI"/>
    <dbReference type="OrthoDB" id="630188at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07379">
        <property type="entry name" value="MPP_239FB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051693">
        <property type="entry name" value="UPF0046_metallophosphoest"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905:SF0">
        <property type="entry name" value="CALCINEURIN-LIKE PHOSPHOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905">
        <property type="entry name" value="METALLOPHOSPHOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="1">
        <location>
            <begin position="35"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH37820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="247" mass="27125" checksum="51EF7DF9D1B6BC6B" modified="2018-01-31" version="1">MPATDSAIMSTATSAVYVTYDVDNPPPHPGPSWTRFVCISDTHSHIYSVPPGDVLLHSGDLSNGGYLDRLRVTVEWLRSLPHPIKIFIAGNHDTVARAQDLVRNDASRSAGMCYLEHDSVVITAPSGREWEVYGSPASPRHSCGAFQYEYDEGAELYKIIPPTIDVLLTHTPPFDICDRTRKGKRAGCRDLADRLKSEDLQRCRLHVFGHIHESHGAQLIGNGDRARVSVNAALAYGGQAVIVDLKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J6R4</accession>
    <name>A0A2H3J6R4_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Arrestin C-terminal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_148865</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
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                <person name="Benoit I."/>
                <person name="Boyd A."/>
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                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
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                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
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                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
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                <person name="Ohm R.A."/>
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            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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            </authorList>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
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</entry>
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    <name>A0A2H3J850_WOLCO</name>
    <protein>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Ferreira P."/>
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                <person name="Foster B."/>
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                <person name="Glotzer D."/>
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                <person name="Hesse C."/>
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                <person name="Kallen N."/>
                <person name="Kersten P."/>
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                <person name="Kumar T.K.A."/>
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                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
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                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat mio family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467865">
        <property type="protein sequence ID" value="PCH35953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J850"/>
    <dbReference type="STRING" id="742152.A0A2H3J850"/>
    <dbReference type="OMA" id="RTKAACW"/>
    <dbReference type="OrthoDB" id="341486at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16691">
        <property type="entry name" value="mRING-H2-C3H3C2_Mio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037593">
        <property type="entry name" value="MIOS/Sea4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049092">
        <property type="entry name" value="MIOS_a-sol"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031488">
        <property type="entry name" value="Zn_ribbon_mio"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16453:SF9">
        <property type="entry name" value="GATOR COMPLEX PROTEIN MIOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16453">
        <property type="entry name" value="WD40 DOMAIN-CONTAINING PROTEIN MIO FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21719">
        <property type="entry name" value="MIOS_a-sol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21720">
        <property type="entry name" value="MIOS_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17034">
        <property type="entry name" value="zinc_ribbon_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="MIOS-like alpha-solenoid" evidence="6">
        <location>
            <begin position="769"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="domain" description="GATOR2 complex protein MIO zinc-ribbon like" evidence="5">
        <location>
            <begin position="1048"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="325"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="474"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="717"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="335"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="355"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="481"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF21719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PCH35953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="1136" mass="126224" checksum="0A85030B9C31F7E6" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J8I1</accession>
    <name>A0A2H3J8I1_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kinase</fullName>
            <ecNumber evidence="4">2.7.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WOLCODRAFT_97274</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the inositol phosphokinase (IPK) family.</text>
    </comment>
    <dbReference type="EC" id="2.7.-.-" evidence="4"/>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH38530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J8I1"/>
    <dbReference type="STRING" id="742152.A0A2H3J8I1"/>
    <dbReference type="OMA" id="FRICGMK"/>
    <dbReference type="OrthoDB" id="338650at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000824">
        <property type="term" value="F:inositol-1,4,5,6-tetrakisphosphate 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008440">
        <property type="term" value="F:inositol-1,4,5-trisphosphate 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.160">
        <property type="entry name" value="Inositol polyphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005522">
        <property type="entry name" value="IPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038286">
        <property type="entry name" value="IPK_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400:SF108">
        <property type="entry name" value="KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03770">
        <property type="entry name" value="IPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="245"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PCH38530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="309" mass="33678" checksum="9618B9D37200DBA3" modified="2018-01-31" version="1">MSSQPGPSHVPLAAQVGGHPGVMTTQDGFLLVKPSLPKETAFYTSISQEPHLLILQDYVPKFYGTLRLEGKVASEEVALNEPDAIRPVEGHIVLENLTYTFLKPNILDVKLGTVLYDEDATPEKRARMEKTARETTTSETGIRLTGFQVYDLVADKPIVTPKGYGKSIKAAELPEGIARFFPLASSATPAESTSDSIGTGLPKDILLPLLSDLRLEIQELHDVLARLDVRMVGASLLILYEADWDQDEDEEEEDEEDGKKPIGPPSIVKLIDFAHSKLALGEGPDEGVLLGLRTFIGLLDGRIEQVKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J913</accession>
    <name>A0A2H3J913_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Recombination protein Rad52</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WOLCODRAFT_145721</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RAD52 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467843">
        <property type="protein sequence ID" value="PCH35239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J913"/>
    <dbReference type="STRING" id="742152.A0A2H3J913"/>
    <dbReference type="OMA" id="FAPQMHG"/>
    <dbReference type="OrthoDB" id="206565at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000730">
        <property type="term" value="P:DNA recombinase assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045002">
        <property type="term" value="P:double-strand break repair via single-strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.80:FF:000001">
        <property type="entry name" value="DNA repair protein RAD52 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.80">
        <property type="entry name" value="DNA repair protein Rad52/59/22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004585">
        <property type="entry name" value="DNA_recomb/repair_Rad52"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041247">
        <property type="entry name" value="Rad52_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007232">
        <property type="entry name" value="Rad52_Rad59_Rad22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042525">
        <property type="entry name" value="Rad52_Rad59_Rad22_sf"/>
    </dbReference>
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        <property type="entry name" value="rad52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12132">
        <property type="entry name" value="DNA REPAIR AND RECOMBINATION PROTEIN RAD52, RAD59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12132:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD52 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04098">
        <property type="entry name" value="Rad52_Rad22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="224"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="610"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="225"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="266"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="348"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="369"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="389"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="421"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="479"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="517"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="549"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PCH35239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="657" mass="69236" checksum="741CF75F89B68DB7" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J9V3</accession>
    <name>A0A2H3J9V3_WOLCO</name>
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        <recommendedName>
            <fullName evidence="6">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WOLCODRAFT_161759</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin-conjugating enzyme family.</text>
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    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="UBCc_UBE2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
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        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="6">
        <location>
            <begin position="29"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH38701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="179" mass="19214" checksum="32F2005D4A894285" modified="2018-01-31" version="1">MEQLTTSLAPPRNAPKPAVAGAHSESAGSVTKRLGNELMSLMMSSSPGISAFPKSDANLFEWAGTIEGPAGTVYAGLTFKISISFPSNYPYAAPTIKFDTPCYHPNVDITVGAICLDILQDKWSAVYSVQTILLSLQSLLGEPNNASPLNPDAANVWDSPEEFKQQLLKHYRPIDDTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JA36</accession>
    <name>A0A2H3JA36_WOLCO</name>
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        <submittedName>
            <fullName evidence="5">Peroxisomal biogenesis factor 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WOLCODRAFT_61359</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH33514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JA36"/>
    <dbReference type="STRING" id="742152.A0A2H3JA36"/>
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    <dbReference type="OrthoDB" id="411017at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008733">
        <property type="entry name" value="PEX11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12652:SF50">
        <property type="entry name" value="PEROXIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12652">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05648">
        <property type="entry name" value="PEX11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="1" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00046271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PCH33514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="227" mass="25413" checksum="E8EAEE9757F63B0C" modified="2018-01-31" version="1">MSTVASQVILHPVVSQSLKVLGTNLGRDKLYRAVQYFSRFLAWYLLAREYKIEAARWSALKSHLTIARKLMRLGKPVEHLQAALRAAQLNADFGEQLTSICRQLGYFGYLSYDALVWANTVKFFNLKPSTAEKVSKNANRFWFAGILFSIVHGLLKAGRLANEAKRLHNAQFSDKGDTADREAKLKALSVTREATRTQFIVDLLDIWIPATNIGIANLNDGVLGIFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JA70</accession>
    <name>A0A2H3JA70_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_85208</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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        </citation>
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        </source>
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    <feature type="non-terminal residue" evidence="1">
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            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="178" mass="20088" checksum="D84E710EE0F8C515" modified="2018-01-31" version="1" fragment="single">LRASNLIGYDIPGVAEHLIATLFADDTTVFLKKNDRLSDLMAVLDTWCAVSGAKFNKEKTEIIPIGQPKYHHDLVRTRKPTVHMDPIPEHIRIATDGEAVRILEAWYGNGVDATAIWTPTLEKIDATLDWWAARHPTLEGQKHIVQMTIGGMTQYLTKAQGMPKHVEQRLVKRVRAFL</sequence>
</entry>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
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                <person name="Nolan M."/>
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                <person name="Syed K."/>
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                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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    </dbReference>
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            <end position="74"/>
        </location>
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        <location>
            <begin position="39"/>
            <end position="63"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH39180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Barry K."/>
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                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
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                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
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                <person name="Larrondo L.F."/>
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                <person name="Ling A."/>
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                <person name="Lundell T."/>
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                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
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                <person name="Wiebenga A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="PCH36803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="561" mass="63594" checksum="34285F50FB1C1D8C" modified="2018-01-31" version="1"> </sequence>
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<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JC98</accession>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
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                <person name="Jurgens J.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD-104</strain>
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            <name>heme</name>
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    <comment type="similarity">
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="project" value="UniProtKB-KW"/>
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            <fullName evidence="2">DUF6533 domain-containing protein</fullName>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
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                <person name="Hori C."/>
                <person name="Igarashi K."/>
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                <person name="Kallen N."/>
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            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
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    </evidence>
    <sequence length="206" mass="23369" checksum="8E8DD8181F9916DA" modified="2018-01-31" version="1" fragment="single">SLLNRPLSAVSCYDYLLTLDREIKFIWKVGLSFTTIFFYSYRYPILLNAILEILGRVMWSWQNVPDSPRTVCIALAQGSPVFASLRVYAMYGRREWLFVVVLLIGLLSPTIWIYVFITTSPRQNGINGFWSCKLIILDPHGMVMGARAASLLSDGIVLVLTCMKTVRRGAMRKIIMLGDSEPTLGDILLKDSMYRSQWLCSITLQG</sequence>
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            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        </location>
    </feature>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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            <dbReference type="Pfam" id="PF07992"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH34804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="576" mass="64227" checksum="0C37887E5275D4C2" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JDQ0</accession>
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    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6533 domain-containing protein</fullName>
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    <gene>
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                <person name="Riley R."/>
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                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468053">
        <property type="protein sequence ID" value="PCH40382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JDQ0"/>
    <dbReference type="OrthoDB" id="2756498at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH40382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="129" mass="14363" checksum="5CCA7F91C277A3CE" modified="2018-01-31" version="1" fragment="single">LIIYDYVLTASQEVKYVWGNRVTLPAAVFYCNRYLVVAYGIIGICSILPWSNFAVRLPLISKRSCLTLVCRGVFFASFSALRVYAVSGQNIQLTLTVGILALVCTVCELVWLEILGDEQSISTRTSRCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JEZ6</accession>
    <name>A0A2H3JEZ6_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Succinate dehydrogenase [ubiquinone] cytochrome b small subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WOLCODRAFT_133512</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion inner membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the CybS family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467832">
        <property type="protein sequence ID" value="PCH34567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JEZ6"/>
    <dbReference type="STRING" id="742152.A0A2H3JEZ6"/>
    <dbReference type="OMA" id="SEGSYHW"/>
    <dbReference type="OrthoDB" id="18577at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098796">
        <property type="term" value="C:membrane protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048039">
        <property type="term" value="F:ubiquinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03496">
        <property type="entry name" value="SQR_TypeC_CybS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1300.10:FF:000007">
        <property type="entry name" value="Succinate dehydrogenase [ubiquinone] cytochrome b small subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase, transmembrane subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007992">
        <property type="entry name" value="CybS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13337">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13337:SF2">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE [UBIQUINONE] CYTOCHROME B SMALL SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05328">
        <property type="entry name" value="CybS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="Fumarate reductase respiratory complex transmembrane subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="binding site" description="axial binding residue" evidence="11">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <note>ligand shared with SDHC</note>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>a ubiquinone</name>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <note>ligand shared with IP/SDHB</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00007294"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR607992-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR607992-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU364031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PCH34567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="167" mass="17932" checksum="7E8E43B8058DE6AA" modified="2018-01-31" version="1">MSASLIARSAVNQRIASTFARSSLRPLAFTARSVSDAAYVPGGPIYKGTVNDPTTFPPPSKTHGSYHWAFERLLSAGLVPLTAAAFVTSGSSHALLDGLLGMSLVMHSHIGFDSVLVDYLHPRKFPILGRALTWALRATTVTVLVGVYQFNTNDIGLIELIAKVWHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JF60</accession>
    <name>A0A2H3JF60_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ras-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WOLCODRAFT_139481</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467832">
        <property type="protein sequence ID" value="PCH34637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JF60"/>
    <dbReference type="STRING" id="742152.A0A2H3JF60"/>
    <dbReference type="OMA" id="RVHKMDV"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001918">
        <property type="entry name" value="Small GTP-binding protein Rab18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
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        </location>
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</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JFD0</accession>
    <name>A0A2H3JFD0_WOLCO</name>
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        <submittedName>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
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                <person name="Lundell T."/>
                <person name="Martin R."/>
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                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
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                <person name="Sabat G."/>
                <person name="Salamov A."/>
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                <person name="Stenlid J."/>
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                <person name="Wiebenga A."/>
                <person name="Young D."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="460" mass="49794" checksum="AABEFDCD65F0E010" modified="2018-01-31" version="1">MLPFPRPQNISNFEVERMPGNLQASQTPPQLYMEMSPTDVDSESAFRASIAALISAKARPFAVSGRIPIDPAALTLFFRSKSRITHSIDFPIDIDHDLPPSMEVLIEACQPRALPYNDPKSAENPSLFYPQDLPLTTSLELANHPILDAVRNTLFPSLPMGHYLTAIRDKLELVLNGGSTAMHRRPTDKRVATVIVTLPVRFRGGALVVRCADGREERFTGRGGKGGDLEWVAFTGDCDYAVDAVQKGCKATISYGVQLRSFGPAAIQPDPLIAPSDQFLDMLSPILNASRGRRIALYLTGDYGVDPGEVLAETLVANLKGGDSVLYHAIKLYKLAPELRWTAGGYIWPVDQTVQIGSDSSDSPNSVNAHIPTSFVDGGRSPPMRGLFSAAGPGSSDLGDEDGLRRRIKKSGATAIADTDIIILSNVGLKGTISKERVPFVHSGELERLVVNVLLVVFVP</sequence>
</entry>
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    <accession>A0A2H3JFR0</accession>
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        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
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        <lineage>
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
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                <person name="St John F."/>
                <person name="Stenlid J."/>
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                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
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                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
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        <location>
            <begin position="19"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH34827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="69" mass="7778" checksum="179E24F59CF89794" modified="2018-01-31" version="1">MLLVLPVMVQLLLPPCLLEPYMVDEAEAAQDFAERYYATHFAVNSNDMCSTTTLNSRDVNHPPSVRLQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JG52</accession>
    <name>A0A2H3JG52_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
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        </lineage>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
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                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
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                <person name="Lindquist E."/>
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                <person name="Martin R."/>
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                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
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                <person name="Sabat G."/>
                <person name="Salamov A."/>
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                <person name="Stenlid J."/>
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                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
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                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467887">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="742152.A0A2H3JG52"/>
    <dbReference type="OMA" id="PEWMENA"/>
    <dbReference type="OrthoDB" id="3147752at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="88"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH36678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="525" mass="59221" checksum="755EE8BEEC7E47AE" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JG88</accession>
    <name>A0A2H3JG88_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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    <gene>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
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                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH41646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JHI7"/>
    <dbReference type="STRING" id="742152.A0A2H3JHI7"/>
    <dbReference type="OMA" id="ANNTEGF"/>
    <dbReference type="OrthoDB" id="660550at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase A1" evidence="2">
        <location>
            <begin position="59"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH41646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="387" mass="41183" checksum="9241ACE75DF3AADA" modified="2018-01-31" version="1">MYLKLSTRLTYAVGILHCFGGGIASTSKLVKVPASTILLSQLKTADNHSAPTLNAALKTAVAVNAGDNQTFSYVEIDTGSAIFWVGAGQKYVPGPHTQIINQTFSESYGDGYANGTVYLDRVTIGEATVKSQLIGSASYISGFQVSEPNFDGFLGLGPNGSNAHEISGYDTTPTFVQSLVSEGAIDEPVFGIYLSPLYSDSPEGDGEITFGGVDSSRLVGDISWIPLSDELHWDFEGSYFGWGDEYIVNGTVYARTDSGAPFLGIPFDPYIWLLQNTPGISADPNYGTLTFPANMSDSLPPVYIGVGDLNVTVPPSNGAGRYTIPKSLYSTLNITDDGEIHTFISTSGPDEVDLGFLFLQIVYSAYDIHSASEVANNRVGFALAASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JI28</accession>
    <name>A0A2H3JI28_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">2OGFeDO JBP1/TET oxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WOLCODRAFT_86174</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD-104</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KB468119">
        <property type="protein sequence ID" value="PCH41836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JI28"/>
    <dbReference type="STRING" id="742152.A0A2H3JI28"/>
    <dbReference type="OMA" id="RSTSWRM"/>
    <dbReference type="OrthoDB" id="2802946at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024779">
        <property type="entry name" value="2OGFeDO_JBP1/TET_oxygenase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12851">
        <property type="entry name" value="Tet_JBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2OGFeDO JBP1/TET oxygenase" evidence="6">
        <location>
            <begin position="124"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PCH41836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="298" mass="33788" checksum="4A1DFC7D88D0DB8D" modified="2018-01-31" version="1">MLGSRPSGTNEILELRLERKWGPVQQGPPLEISRPSIIIDEHNKILAWCLPLVLSERRQVCVHLKFKKTPNDSAEEPSRSTSWRMDRWYFREWSQLELNSGVVNLSPGWHHQGHEGLDDPIHISTSLRDKNKQAGDEWLRDIQESSAILSGMMAVMHPDLHAAGQECMRRLAQNEDLKDTLQRWASIFNGAQIISNRVTPAHRDSKSCMQWYDLLASIGSYHNASLDLHGANISIKDGPGTVIALCGTAVRHSLMKYEGDRLCYAYFMRDSVHASMHVEAAGWCKMDHMEALLMLQGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JI71</accession>
    <name>A0A2H3JI71_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial proton/calcium exchanger protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Leucine zipper-EF-hand-containing transmembrane protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">WOLCODRAFT_136287</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LETM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH38449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JI71"/>
    <dbReference type="STRING" id="742152.A0A2H3JI71"/>
    <dbReference type="OMA" id="QNEMIAD"/>
    <dbReference type="OrthoDB" id="275278at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033122">
        <property type="entry name" value="LETM1-like_RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044202">
        <property type="entry name" value="LETM1/MDM38-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14009">
        <property type="entry name" value="LEUCINE ZIPPER-EF-HAND CONTAINING TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14009:SF1">
        <property type="entry name" value="MITOCHONDRIAL PROTON_CALCIUM EXCHANGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07766">
        <property type="entry name" value="LETM1_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51758">
        <property type="entry name" value="LETM1_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0050">Antiport</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Letm1 RBD" evidence="15">
        <location>
            <begin position="193"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="14">
        <location>
            <begin position="569"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="63"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="420"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="420"/>
            <end position="431"/>
        </location>
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        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51758"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH38449.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="634" mass="71887" checksum="E8428784FCCC421E" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
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    <name>A0A2H3JIM4_WOLCO</name>
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            <fullName evidence="3">Carboxymuconolactone decarboxylase-like domain-containing protein</fullName>
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        <name evidence="1" type="ORF">WOLCODRAFT_15966</name>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
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                <person name="St John F."/>
                <person name="Stenlid J."/>
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                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
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    </dbReference>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="245" mass="26444" checksum="33F166549FFCCF7D" modified="2018-01-31" version="1">MAAVATAEFLKQLSDIYPSGEASTPEAILEQPWFLSAAVAFSASNQGTAVPALFKYVLAQLEQAQSGVAPEQKLAQKLALANKFREALLQSTLLVGIPRITESLLALHSAVPEELHAKDITRDRTKSIADYENAGEQMFKVIYGDTADNMHKLLFGAYPDFGWFVVTAAYGITGASKVLTRVQTSATIISALIPTDAARQLQWHMGNARKAGASVEQVKAIREIAIKISEKANITWKDGIPDVSA</sequence>
</entry>
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                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
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                <person name="Benoit I."/>
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                <person name="Copeland A."/>
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                <person name="Ferreira P."/>
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                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
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                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
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                <person name="Lundell T."/>
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                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
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                <person name="Sabat G."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
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    </dbReference>
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            <position position="1"/>
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    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH42036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="211" mass="23477" checksum="9048C2DA99A50C90" modified="2018-01-31" version="1" fragment="single">LHHIAAILPIPLLLRRISTNAAIRIHTLPTSAQIRTRLPPPWPLPRNQTAPYPLSDTIVRRSRRPLTIVHHLASLIPVDAETTDPYYTAPWDRQHSWGERLQADVPDSRLTKDQRKAYIDGLQTTLTRGRMDPSTLFIFTDGSRRRAGRPHRLTGAGYAAYLVGAEVRSSQLGLGQKASIYDAELLALAAAAFALPALLARHPTVCTVYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JIQ6</accession>
    <name>A0A2H3JIQ6_WOLCO</name>
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            <fullName evidence="3">Arrestin-like N-terminal domain-containing protein</fullName>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
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                <person name="Copeland A."/>
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                <person name="Ferreira P."/>
                <person name="Findley K."/>
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                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
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                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
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                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
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                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
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                <person name="Stenlid J."/>
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                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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            <position position="1"/>
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    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH42080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="299" mass="32828" checksum="AAC8E4AF48A46F28" modified="2018-01-31" version="1" fragment="single">PFFVSGDKITGSVEVDLDIARNARGLSVAVIAGVTAVGQEEAVFLNVPQTLWDNTTVSPRKSAGIRAWPFSIQLPSEVTINVKGGRASQKFPLPPSFSERASPAYVEYRLIATVRRGFLRANQTLIRSFVYLPTWRAEPPSLLRQVAYREGTPLIGPDHDSEGWEMPAPVVIIGSLFSTRQIELRCSLAVARPLSYAKGTLIPLLLTIQGEDEQAIDLLATPAAVKIYLIRCRVLGTHATDQEESTVRSDHVFRDTVDTAYFWPSTDTASAGSRARTLRGELRIKSSLKPSFVFPGFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JJ02</accession>
    <name>A0A2H3JJ02_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">deoxyhypusine synthase</fullName>
            <ecNumber evidence="7">2.5.1.46</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WOLCODRAFT_131973</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[eIF5A protein]-L-lysine + spermidine = [eIF5A protein]-deoxyhypusine + propane-1,3-diamine</text>
            <dbReference type="Rhea" id="RHEA:33299"/>
            <dbReference type="Rhea" id="RHEA-COMP:10143"/>
            <dbReference type="Rhea" id="RHEA-COMP:10144"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57484"/>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
            <dbReference type="ChEBI" id="CHEBI:82657"/>
            <dbReference type="EC" id="2.5.1.46"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Protein modification; eIF5A hypusination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the deoxyhypusine synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.46" evidence="7"/>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH41515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JJ02"/>
    <dbReference type="STRING" id="742152.A0A2H3JJ02"/>
    <dbReference type="OMA" id="HSIINAN"/>
    <dbReference type="OrthoDB" id="294378at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034038">
        <property type="term" value="F:deoxyhypusine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.910.10:FF:000001">
        <property type="entry name" value="Probable deoxyhypusine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.910.10">
        <property type="entry name" value="Deoxyhypusine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002773">
        <property type="entry name" value="Deoxyhypusine_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036982">
        <property type="entry name" value="Deoxyhypusine_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00321">
        <property type="entry name" value="dhys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11703">
        <property type="entry name" value="DEOXYHYPUSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11703:SF0">
        <property type="entry name" value="DEOXYHYPUSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01916">
        <property type="entry name" value="DS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0386">Hypusine biosynthesis</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PCH41515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="360" mass="39836" checksum="804A7D4A2E28FA44" modified="2018-01-31" version="1">MANLPPGDASAAVLKPSEPVPEAAVSVEGPNFDKPISLQQLLESYQRIGFQASSLAKAIDIVNKMRKWRLSDEPIEEDESEELRDSEVRANIRCDVFLGYTSNLISSGLREVILHLVKHKHVRALVTTAGGIEEDFIKCLGKTYLADFNLDGADLRRRGMNRIGNLIVPNDNYCKFEDWLTPILDTMLAEQKETGEVWTPSSFIRRLGKEINNEESVYYWAYKNDIPVFCPALTDGSLGDMLYFHSFRSPGLIVDIVRDIRSLNELARQSKKAGMIILGGGVCKHQIANAMLIRNGADYSVYINTGQEFDGSDSGARPDEAVSWGKIRAGAESVKVFADATLVFPMLVAATFAQDVAQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JJ43</accession>
    <name>A0A2H3JJ43_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="4">PPIase</shortName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WOLCODRAFT_25018</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 9">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="KB468124">
        <property type="protein sequence ID" value="PCH41881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JJ43"/>
    <dbReference type="STRING" id="742152.A0A2H3JJ43"/>
    <dbReference type="OMA" id="DHILYKP"/>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000025">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase CYP19-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="5">
        <location>
            <begin position="8"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PCH41881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="168" mass="18587" checksum="7B4078E54090135A" modified="2018-01-31" version="1">MIQGPNVFFDISINSMPAGRIVFRLFDNVCPMTARNFRELASGEHGFGYAHSTIHRIIPDFMIQGGDIQGGDGAGGRSIYGPRFPDENFRLKHDRPGLLSMANRAPHSNNSHFFITTAPAPWCDGRNVVFGEVVSGMDVVRKIQSYYSPDDILRRPSVPIVITHSGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JJ62</accession>
    <name>A0A2H3JJ62_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_81251</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467865">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="742152.A0A2H3JJ62"/>
    <dbReference type="OrthoDB" id="2576334at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH36027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="238" mass="25616" checksum="A4CBC617D47A7CDF" modified="2018-01-31" version="1">MNSQVAPYNFSFTDQYAMLRYFPSRDGAPNETWNVSYSESSQSSWAPTEKSRWGNGTSAHSTTRVNGAVTISWLGTAIWLYGKGEINDYGVQIDNGPLMFGRGSNSEGLLFSQTDLNYTWHSAILSLIHGELVFTGGTITTGMGQEGWSVQYRTIQAATTTSPGLPEINPIFSSAGAGWSMARSFQYPRLSCGSEGSSVSFNLSNASGFSIFGSVDGTSGAFSVYIILPQAVSPTVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JJQ4</accession>
    <name>A0A2H3JJQ4_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WOLCODRAFT_25108</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="PCH42081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="TF_fung"/>
    </dbReference>
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        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="32"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PCH42081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="68" mass="7631" checksum="73602CDD607EA71C" modified="2018-01-31" version="1">MSDRDHSQNDTKSDDSDGETYSPRTPRRTPMACQFCRGRKMKCDGRPICANCSRRGIACSYVPVSAQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JK45</accession>
    <name>A0A2H3JK45_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MINDY deubiquitinase domain-containing protein</fullName>
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        <name evidence="3" type="ORF">WOLCODRAFT_72130</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Agaricomycetes</taxon>
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            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468124">
        <property type="protein sequence ID" value="PCH42550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JK45"/>
    <dbReference type="STRING" id="742152.A0A2H3JK45"/>
    <dbReference type="OMA" id="QDAIIIR"/>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016807">
        <property type="term" value="F:cysteine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071108">
        <property type="term" value="P:protein K48-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007518">
        <property type="entry name" value="MINDY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033979">
        <property type="entry name" value="MINDY_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18063">
        <property type="entry name" value="NF-E2 INDUCIBLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18063:SF6">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF04424">
        <property type="entry name" value="MINDY_DUB"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MINDY deubiquitinase" evidence="2">
        <location>
            <begin position="519"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="495"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="841"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="501"/>
            <end position="515"/>
        </location>
    </feature>
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            <end position="853"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH42550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="879" mass="97527" checksum="2AAE83419F7275FA" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JKB6</accession>
    <name>A0A2H3JKB6_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 10">Man(5)GlcNAc(2)-PP-dolichol translocation protein RFT1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WOLCODRAFT_98669</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Intramembrane glycolipid transporter that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. RFT1 could mediate the translocation of the cytosolically oriented intermediate DolPP-GlcNAc2Man5, produced by ALG11, into the ER lumen where dolichol-linked oligosaccharides assembly continues. However, the intramembrane lipid transporter activity could not be confirmed in vitro.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the RFT1 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="742152.A0A2H3JKB6"/>
    <dbReference type="OMA" id="WPGKLFG"/>
    <dbReference type="OrthoDB" id="9979195at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034203">
        <property type="term" value="P:glycolipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007594">
        <property type="entry name" value="RFT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13117">
        <property type="entry name" value="ENDOPLASMIC RETICULUM MULTISPAN TRANSMEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN RFT1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04506">
        <property type="entry name" value="Rft-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0256">Endoplasmic reticulum</keyword>
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    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
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            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="193"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="328"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="375"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="407"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="433"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="465"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="505"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365067"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH40303.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="541" mass="58941" checksum="FEC699CC99DE351F" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JKD1</accession>
    <name>A0A2H3JKD1_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Vps72/YL1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WOLCODRAFT_134465</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB467909">
        <property type="protein sequence ID" value="PCH37114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JKD1"/>
    <dbReference type="STRING" id="742152.A0A2H3JKD1"/>
    <dbReference type="OMA" id="HSKHYCD"/>
    <dbReference type="OrthoDB" id="49520at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029525">
        <property type="entry name" value="INO80C/Ies6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013272">
        <property type="entry name" value="Vps72/YL1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31200">
        <property type="entry name" value="INO80 COMPLEX SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31200:SF1">
        <property type="entry name" value="INO80 COMPLEX SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08265">
        <property type="entry name" value="YL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00993">
        <property type="entry name" value="YL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Vps72/YL1 C-terminal" evidence="6">
        <location>
            <begin position="90"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="38"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PCH37114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="141" mass="16373" checksum="D060189EDFB01FE8" modified="2018-01-31" version="1">MSLSEQFSYLQSPRPFKNPKYIKNANRRTKNLKAVLAQERERERQERERRRQEKEESMDVDGEQREPTPEEEMPTYSSIEAPPSVLPPRRYCDITGLEGPYTDPATGLRYHDKSIYELIKGLSSTAAKDYLVARGVNPIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JLY6</accession>
    <name>A0A2H3JLY6_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_44498</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH38738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JLY6"/>
    <dbReference type="STRING" id="742152.A0A2H3JLY6"/>
    <dbReference type="OMA" id="WHSIARI"/>
    <dbReference type="OrthoDB" id="2423954at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH38738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="436" mass="49947" checksum="C1E60C30669EAF9F" modified="2018-01-31" version="1" fragment="single">VLKQEVVQAEGSMRTQFHQGAYTVLQGDGWKDISKKHLVAFMHVTQRKAYVLHVHDISAKRKTGENIFALMESEYEYIQDMLKLKCIGMCGDTASDERKGRMNVPLHSESYLTMSTCKLCLILGDYYKQNPQVKSLVDEAILVIKWFNNHSYALGVLNEEQMSMYKKSHALIMPVVTRWTSNFCALDRLLDIWKAIQMTSIKHEDRLVESVGQKHSAKTKATQVLALVKDTTWWKALTAIKLHIEPLAIATNVSQGATTRCDQVLLILGNLLEKRWAKADQDLFIACLFLNPFINSNLIDANTLSVAIIMGITRRLYLRVFQLDVPPPDLIHEVYDYAERKNRYSPDCWPIEDLRRRRDNPSEDCNVDPISAWTIISQDSSLVKLAILVLSFVPNSASMERLFSSMGHTKTKTRSCLGIQKNRDIAFLKMELRRRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JM39</accession>
    <name>A0A2H3JM39_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">E2 ubiquitin-conjugating enzyme</fullName>
            <ecNumber evidence="1">2.3.2.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WOLCODRAFT_138121</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="1"/>
    <dbReference type="EMBL" id="KB468135">
        <property type="protein sequence ID" value="PCH42941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JM39"/>
    <dbReference type="STRING" id="742152.A0A2H3JM39"/>
    <dbReference type="OMA" id="WKSTYGI"/>
    <dbReference type="OrthoDB" id="10069349at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23804">
        <property type="entry name" value="UBCc_UBE2S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000031">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="9">
        <location>
            <begin position="6"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="150"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="162"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="214"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="244"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PCH42941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="292" mass="30744" checksum="A4C002D01928C89E" modified="2018-01-31" version="1">MSVSPAVMRRLMRELSELQTNPPEGIRVVTSEDNLLDVTGIIEGPEGTPYAGGYFRVKFAFTEEFPAAPPRCRMLTKIFHPNVSSAGEICVNTLKKDWKSTYGIGHILVTVKCLLIYPNPESALDEEAGKLLLGNYDSYCERAKLITSVHATPRTRPTEFDAPSSSSSNTNTNTTSTKTTTKPVSTSATPVTSVPAAASKASSTATSATTTVSQPLKTSASNTMPTSTSTGSVKGEATGKERLSSPSPLGTADSNIASAVNAVAPGAEAKAVKRTATGIMGAEKRKKALKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JM49</accession>
    <name>A0A2H3JM49_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">peptide-methionine (S)-S-oxide reductase</fullName>
            <ecNumber evidence="2">1.8.4.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Peptide-methionine (S)-S-oxide reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WOLCODRAFT_138277</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-methionyl-[protein] + [thioredoxin]-disulfide + H2O = L-methionyl-(S)-S-oxide-[protein] + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:14217"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12315"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:44120"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[thioredoxin]-disulfide + L-methionine + H2O = L-methionine (S)-S-oxide + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:19993"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58772"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MsrA Met sulfoxide reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.11" evidence="2"/>
    <dbReference type="EMBL" id="KB468135">
        <property type="protein sequence ID" value="PCH43286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JM49"/>
    <dbReference type="STRING" id="742152.A0A2H3JM49"/>
    <dbReference type="OMA" id="LFWESHD"/>
    <dbReference type="OrthoDB" id="77405at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008113">
        <property type="term" value="F:peptide-methionine (S)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1060.10:FF:000006">
        <property type="entry name" value="Peptide methionine sulfoxide reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1060.10">
        <property type="entry name" value="Peptide methionine sulphoxide reductase MsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01401">
        <property type="entry name" value="MsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002569">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036509">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00401">
        <property type="entry name" value="msrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43774">
        <property type="entry name" value="PEPTIDE METHIONINE SULFOXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43774:SF1">
        <property type="entry name" value="PEPTIDE METHIONINE SULFOXIDE REDUCTASE MSRA 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01625">
        <property type="entry name" value="PMSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55068">
        <property type="entry name" value="Peptide methionine sulfoxide reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptide methionine sulphoxide reductase MsrA" evidence="7">
        <location>
            <begin position="9"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PCH43286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="177" mass="19988" checksum="40310C244E8619AF" modified="2018-01-31" version="1">MAGSQPEIATFAAGCFWGVEHIFLKHYPIAQNKGILRTAVGYTGGKPDATNPDYRTVCTGTTDHAESLRIEFDPAVVSYAELVEFFYRTHDPTTLNSQGADVGTQYRSAIFYHSPAQLETAQRVTAEVQKKHFEPIGKKIVTQIVSAGEWWDAEEYHQEYLHKNPTGYQCPTHRLHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JMP8</accession>
    <name>A0A2H3JMP8_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 12">Uroporphyrinogen decarboxylase</fullName>
            <ecNumber evidence="6 12">4.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">WOLCODRAFT_137233</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>uroporphyrinogen III + 4 H(+) = coproporphyrinogen III + 4 CO2</text>
            <dbReference type="Rhea" id="RHEA:19865"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57308"/>
            <dbReference type="ChEBI" id="CHEBI:57309"/>
            <dbReference type="EC" id="4.1.1.37"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the uroporphyrinogen decarboxylase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.37" evidence="6 12"/>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH41173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JMP8"/>
    <dbReference type="STRING" id="742152.A0A2H3JMP8"/>
    <dbReference type="OMA" id="LWLMRQA"/>
    <dbReference type="OrthoDB" id="339900at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00321"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004853">
        <property type="term" value="F:uroporphyrinogen decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00717">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.210:FF:000001">
        <property type="entry name" value="Uroporphyrinogen decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00218">
        <property type="entry name" value="URO_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006361">
        <property type="entry name" value="Uroporphyrinogen_deCO2ase_HemE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000257">
        <property type="entry name" value="Uroporphyrinogen_deCOase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01464">
        <property type="entry name" value="hemE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21091">
        <property type="entry name" value="METHYLTETRAHYDROFOLATE:HOMOCYSTEINE METHYLTRANSFERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21091:SF169">
        <property type="entry name" value="UROPORPHYRINOGEN DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01208">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="UROD/MetE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00906">
        <property type="entry name" value="UROD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00907">
        <property type="entry name" value="UROD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 12" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="11 12" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uroporphyrinogen decarboxylase (URO-D)" evidence="14">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="Uroporphyrinogen decarboxylase (URO-D)" evidence="15">
        <location>
            <begin position="146"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00014308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS00907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PCH41173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="362" mass="39911" checksum="2CF557A124927EBE" modified="2018-01-31" version="1">MESDFPPLKNDLLLRAARGEETERAPVWVMRQAGRYLPEFREVRAQHGFFEVCRTPALATEVTLQPIRRYAGLLDAAIIFSDILVVPQAMGMEVEMNPGPFFPAPLDTPADVARLRTHVDVQKELGYVFAAIAQTRRALEGAVPLIGFCGAPWTLFSYMVEGGGSRTYQKAKSWLFMYPEESKALLSLIADVCADFLVGQVKAGAQLLQVFDSWAGELAPHHFQEFALPPLQHIAASVRSKLEAEGIAPVPMTLFPKGTNSQLVLIAERGGYDVVGIDWCIEPAEARRQVGGLVALQGNMDPNVLYGGRAAVEREVKRMCESFKGGRAPKGWIANLGHGITPGVDPEDLRWFFECVHKYSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JMU0</accession>
    <name>A0A2H3JMU0_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TECPR1-like DysF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WOLCODRAFT_138378</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB468146">
        <property type="protein sequence ID" value="PCH43500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JMU0"/>
    <dbReference type="STRING" id="742152.A0A2H3JMU0"/>
    <dbReference type="OMA" id="PPFYILT"/>
    <dbReference type="OrthoDB" id="5586090at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052646">
        <property type="entry name" value="Peroxisomal_PEX28-32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010482">
        <property type="entry name" value="TECPR1-like_DysF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31679">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX30-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31679:SF2">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX30-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06398">
        <property type="entry name" value="Pex24p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="TECPR1-like DysF" evidence="6">
        <location>
            <begin position="20"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="349"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="455"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="363"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="460"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PCH43500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="499" mass="54672" checksum="4961EF10FA632E6E" modified="2018-01-31" version="1">MSVQLPDTRSSSQLPLVDFLNTLPSPLTTALVGLAPYISRVRYGVQILSWKTSWEESWIAIAVWWAVCMLADVGARYCLPLAVMLGLVVARSSQTKQITPAVVTEDMLQQTVADLSTLHALLPVIPPTTPNILPLHVLLRVAAILYVPYLLLTNFVRLRVLLALAGTVLLTWRARWPSLLRRALWRSAYVRWTIYRIWSFLSGQSLPPRIPSASAAAAPAHLETAPEPANSVLFLFTVYENQRWWMGLDWTAALLPGERPAWCTAALQPAPPPAAFALPAPTTVYVRSGSGKDAGARVKRTARWAWGEPEWRVVVHRDGEASARVERPLPQEEAPAVGTASRMLRAAGKMREGSVSLSNGIPERARDEGDVKAPEEEGREGELITDADGWVYADNKWEGASAKGGMGKYTRYRRWTRIAVLSETVEPAGPGDVGIQKDEEVTAPLTATSPVNATVLPDWEPAHGRHDSLDKKIIGQGSHGEDDGLRKRLKAAVQGTAHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JN88</accession>
    <name>A0A2H3JN88_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Queuine tRNA-ribosyltransferase catalytic subunit 1</fullName>
            <ecNumber evidence="6">2.4.2.64</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Guanine insertion enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">tRNA-guanine transglycosylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WOLCODRAFT_74810</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming queuine, allowing a nucleophilic attack on the C1' of the ribose to form the product.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>guanosine(34) in tRNA + queuine = queuosine(34) in tRNA + guanine</text>
            <dbReference type="Rhea" id="RHEA:16633"/>
            <dbReference type="Rhea" id="RHEA-COMP:10341"/>
            <dbReference type="Rhea" id="RHEA-COMP:18571"/>
            <dbReference type="ChEBI" id="CHEBI:16235"/>
            <dbReference type="ChEBI" id="CHEBI:17433"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:194431"/>
            <dbReference type="EC" id="2.4.2.64"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterodimer of a catalytic subunit and an accessory subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the queuine tRNA-ribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.64" evidence="6"/>
    <dbReference type="EMBL" id="KB468146">
        <property type="protein sequence ID" value="PCH43646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JN88"/>
    <dbReference type="STRING" id="742152.A0A2H3JN88"/>
    <dbReference type="OMA" id="IDLFDCV"/>
    <dbReference type="OrthoDB" id="10249838at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008479">
        <property type="term" value="F:tRNA-guanosine(34) queuine transglycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.105">
        <property type="entry name" value="Queuine tRNA-ribosyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00168">
        <property type="entry name" value="Q_tRNA_Tgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004803">
        <property type="entry name" value="TGT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036511">
        <property type="entry name" value="TGT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002616">
        <property type="entry name" value="tRNA_ribo_trans-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00430">
        <property type="entry name" value="Q_tRNA_tgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00449">
        <property type="entry name" value="tgt_general"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43530">
        <property type="entry name" value="QUEUINE TRNA-RIBOSYLTRANSFERASE CATALYTIC SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43530:SF1">
        <property type="entry name" value="QUEUINE TRNA-RIBOSYLTRANSFERASE CATALYTIC SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01702">
        <property type="entry name" value="TGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51713">
        <property type="entry name" value="tRNA-guanine transglycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="5 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA-guanine(15) transglycosylase-like" evidence="7">
        <location>
            <begin position="12"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="RNA binding" evidence="6">
        <location>
            <begin position="248"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="RNA binding; important for wobble base 34 recognition" evidence="6">
        <location>
            <begin position="272"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="267"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PCH43646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="412" mass="44956" checksum="1B83BF165E9F7203" modified="2018-01-31" version="1">MEFEILARCHTTNARVCHMKLPHGVTMLPTFIPVATQAAIKGLSAQQVEALGVSLILNSTYHLNLRPGTEILKEAGGAHRFQGWRHNLITDGGGFSLVSLNKSARVTEEGVLFASPSTGEPIMLTPEESMAIQHAIGSDIMTQLDDVVHTLSVGPRVSEAMWRTVRWLDRCIEHHQKSEKRESQSLFAIVHGGVDPHLRDQCLDEMIKRKDRVAGYAIGGLSSGEKGRTLIKQCADKLPADRPRYCTGVGFPEDLLVCVALGIDMADCVFPTRTARFGVALTFHGPLNIRLKKHAKDFCPIDESCPCPTCASGTSRAMLHHIVTVETAGAHALTQHNIVFQARLMGGARGAIMNGIFPTYLKKFFAEYYGQAGYPEWCVNALNSVGVDLLEGKPDAKVVPGDGAQWEYSDTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JNK6</accession>
    <name>A0A2H3JNK6_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">1-alkyl-2-acetylglycerophosphocholine esterase</fullName>
            <ecNumber evidence="1">3.1.1.47</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WOLCODRAFT_119037</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.1.47" evidence="1"/>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH41483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JNK6"/>
    <dbReference type="STRING" id="742152.A0A2H3JNK6"/>
    <dbReference type="OMA" id="EAFMHWK"/>
    <dbReference type="OrthoDB" id="2363873at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003847">
        <property type="term" value="F:1-alkyl-2-acetylglycerophosphocholine esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10272">
        <property type="entry name" value="PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10272:SF0">
        <property type="entry name" value="PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03403">
        <property type="entry name" value="PAF-AH_p_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PCH41483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="490" mass="54644" checksum="BED68CE29AD89416" modified="2018-01-31" version="1">MFTLPDVPGPFVVGATTFAIPLQQPQTIGAAKLRRTGGNTPREPALLLEEIVFTAFYPADIRKPSTDGTAPEKLKKAMDWVAKPVNKTIRGYAHFAKLPFWLSNVFMGCVASRLKLPVYPNVPLLDPTEASDDPQAQWPLVFFSHGLSGTRTTYSHLCIRLASQGKVVLAMEHRDGTAPVVTSHFEPASAEGKKRHKPKVKYYLHPEDVMYENQEEEQTKSAFRIDQLLFRRLETYLAFMAFSDLINARPRADIEKSLFGNIYTVWGPTCAELPRHSPLWQSWTTGRVQFKENIAIVGHSFGGASTLSIISNPPPSLPDTTSHIRFEPLPITHALVLDPWLEPLPTPGPAPHAGMPRAPHILVLNSEEFTLWDDHFARLAEVVRAWRRTGPGVDAQLLTFIRAKHVSFSDLGVIWPLGHLARDGRTFLRVTGDLALAFLANRTEEAIQGVTKREMEVEHVRKRTLKSAPPGTRRRRIVGGVGEVVVHDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JNN2</accession>
    <name>A0A2H3JNN2_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_146905</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467987">
        <property type="protein sequence ID" value="PCH39338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JNN2"/>
    <dbReference type="OrthoDB" id="10653947at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="140"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="225"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH39338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="249" mass="26867" checksum="69035507C137FF83" modified="2018-01-31" version="1">MSKALKRSGSHYSETTGLDFLQTVNPLSYFDKNRTDKLCVFSLLQSIEPIPSDDDSEKMSGCSSTNTSVDRGSEDIEANQQSHTKSRAAAYAIVVLLPFWIASSYAFLGFMAMTAGKTVLAAALPHDEGYMGNVHLTMQVGAVGGAITGGIIYVIGFLAVIMASLIGCREEFARMASTWKRNTQYKSIFWVLCGTVLGPLGVAVLRNDAQRGLEMLTTTYAAREGAFGMFLMSIAASLLSPSMNDEHGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JNU1</accession>
    <name>A0A2H3JNU1_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rho GTPase activation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WOLCODRAFT_141243</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467987">
        <property type="protein sequence ID" value="PCH39398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JNU1"/>
    <dbReference type="STRING" id="742152.A0A2H3JNU1"/>
    <dbReference type="OMA" id="IAQQDWF"/>
    <dbReference type="OrthoDB" id="3196451at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060237">
        <property type="term" value="P:regulation of fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051025">
        <property type="entry name" value="RhoGAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15228:SF25">
        <property type="entry name" value="F-BAR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15228">
        <property type="entry name" value="SPERMATHECAL PHYSIOLOGY VARIANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="3">
        <location>
            <begin position="63"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="285"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="313"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="340"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PCH39398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="393" mass="44771" checksum="C6DDCAE91BD7FD12" modified="2018-01-31" version="1">MTAVPNIAPQHEPALQQTKAGLKTWWNHFRFAQQAKKEAEEKKAGEGVVFGKPLKESLRYASVQISTANANGELYVWGYIPVVVAKCGLYLKENATEVEGTFRVNGSNKRMRELQAQFESPPKYGKNLDWKKEHYNTHDVASVFRRYLTQMPEPVIPHDMYHYFRDALAKKPFNQDDVIKTYKRLIRSMPRANQYLLLYVLDLLSVFARKSDKNLMTAKNLAVIFRPALIAHPSHELAPQEHQLSQDVLEFLIAHQDWFMLDIPPPPTRSDSSATVPAVSELADLASSDEEQSSGWKMVRRDSVPPRIMRRRTTTEHPGAERLAKPTELGELSPVLESPPSRQESTVSVTRSRTLPPQKSRPQISDEERHAKLVKKQKRTSQQTKRPATASES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JP94</accession>
    <name>A0A2H3JP94_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_18290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
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                <person name="Barry K."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
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        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH39778.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
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    </evidence>
    <sequence length="55" mass="6475" checksum="5328443FCA1F16B9" modified="2018-01-31" version="1" fragment="single">EMLDLCPVDTICHFINKSWCFMDAYHHGLTGKAADWAAKKHRQHWQVFQSDVTEK</sequence>
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                <person name="Yadav J.S."/>
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                <person name="Benoit I."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="154"/>
            <end position="185"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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    </evidence>
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    </evidence>
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</entry>
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                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
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                <person name="Sabat G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH44500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
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                <person name="Benoit I."/>
                <person name="Boyd A."/>
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                <person name="Ferreira P."/>
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                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">MD-104</strain>
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    </evidence>
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        </source>
    </evidence>
    <sequence length="72" mass="8101" checksum="D3EB2834FC885560" modified="2018-01-31" version="1" fragment="single">FRGYKGKAALYTQVSNVALGPSSILLMDTGAHTIREFSCMQCASYLGWMIVRAHEAPERWKEGHYLLELALL</sequence>
</entry>
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                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
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                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
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                <person name="Benoit I."/>
                <person name="Boyd A."/>
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                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
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                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
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                <person name="Ohm R.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6 7">MD-104</strain>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
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                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
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                <person name="Glotzer D."/>
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                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
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                <person name="Kohler A."/>
                <person name="Kuees U."/>
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                <person name="Kuo A."/>
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                <person name="Ling A."/>
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                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
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    </dbReference>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="246" mass="27562" checksum="7CA83E6D49F85097" modified="2018-01-31" version="1">MRLLLTGVTGVAGLSIYRAALADPAISHITVLSRRPIPSWAVLPSDASSKTTTILHTDFLTYPPDLAKRLAENDACVWALGKSAVGMSEEEYTTMTHGFLMAAVRALHDAGVGEGREEGNSFRFVFISGESSDQTEKSQMMWARIKGRAEKDLIEFCKASAGMKAHVFRPAYFCPSPKYPQDRLHQRSFMYRTFDRVMPTIMSCVAPSMWTPVEDLSRFSVGLAKGRWPEQDLYRNSEMRELVKQI</sequence>
</entry>
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                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
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                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
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                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
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                <person name="Morgenstern I."/>
                <person name="Morin E."/>
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                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
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                <person name="Stenlid J."/>
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                <person name="Sun S."/>
                <person name="Syed K."/>
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                <person name="Young D."/>
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                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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            <fullName evidence="2">DUF6533 domain-containing protein</fullName>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
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                <person name="Coutinho P.M."/>
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                <person name="Ferreira P."/>
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                <person name="Martin R."/>
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                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
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                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
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                <person name="Wiebenga A."/>
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                <person name="Eastwood D.C."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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        </source>
    </evidence>
    <sequence length="342" mass="38525" checksum="92C72D5BB6A48BE3" modified="2018-01-31" version="1">MSSNEKTAEYIQDLKAITSFVALLVFEYAITLRQEIDFMWRSGNTKISMAIFFSNRSIFLITALSHLSELWRLLLMFDQSVKSEQILFLFATDASRATWAAFSALWVYAVCKRQWPLAIFTLLLSLLPVAADVTSQAYLYFVVYENFVSEQSALSTLTSSRQSNTIGRTSMVLTVIYSQREGSFLLHNYSQGMVLECFRRLLLILNVIGVVLYYTKQNEAYLAITSGITGVTVIFISRTMLNIREIYAAHDHVELRSVPDHRRRPSGHSRSSTSTVIPKSAFQMHHLKSTITMGEPPCTMSAYNIARNPAEDIIWEEDLIEDGGIDTGGLANYGIGNENACV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JT26</accession>
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            <fullName evidence="2">Uncharacterized protein</fullName>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
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            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <end position="192"/>
        </location>
    </feature>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="210" mass="22539" checksum="1ED6CF647DE93880" modified="2018-01-31" version="1">MDKPPPSNNKRHGGTARLTNRDPRHCPALTTRTVEQRDDPNTPQQSNSIRQTSAQHHWTPPGLTNRGPKGVVPQAAKSRTASNLQSTSGAARSTNRAPPAGRVKGFTHPGAQSGKPSEGKAADTPPRQQQHRGRTKVWHSRKGENADRPQVKRARRHPSGEAMHKPTTTAAAHATATATGHATRTRTASPRRPAAEKRGNTPPCTAIGKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JU03</accession>
    <name>A0A2H3JU03_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_165572</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468168">
        <property type="protein sequence ID" value="PCH45045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JU03"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH45045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="108" mass="11041" checksum="D7B347DC8AECBA33" modified="2018-01-31" version="1">MAVHVYAAPWFHEGQQDPNDVSSDLPGAKLAATTHKRKSVEEPLLAAQHSLGGASRIEGGCLGPGLSRWPSAVSIGEAAIGVVALRSGSAETSRYVAAGKAGVFDSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JUI4</accession>
    <name>A0A2H3JUI4_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Superoxide dismutase [Cu-Zn]</fullName>
            <ecNumber evidence="9">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WOLCODRAFT_136496</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>2 superoxide + 2 H(+) = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="9">Binds 1 copper ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the Cu-Zn superoxide dismutase family.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="9"/>
    <dbReference type="EMBL" id="KB468053">
        <property type="protein sequence ID" value="PCH39797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JUI4"/>
    <dbReference type="STRING" id="742152.A0A2H3JUI4"/>
    <dbReference type="OMA" id="AQRGFHI"/>
    <dbReference type="OrthoDB" id="2015551at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00305">
        <property type="entry name" value="Cu-Zn_Superoxide_Dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.200:FF:000003">
        <property type="entry name" value="Superoxide dismutase [Cu-Zn], chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.200">
        <property type="entry name" value="Superoxide dismutase, copper/zinc binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036423">
        <property type="entry name" value="SOD-like_Cu/Zn_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024134">
        <property type="entry name" value="SOD_Cu/Zn_/chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018152">
        <property type="entry name" value="SOD_Cu/Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001424">
        <property type="entry name" value="SOD_Cu_Zn_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10003">
        <property type="entry name" value="SUPEROXIDE DISMUTASE CU-ZN -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00080">
        <property type="entry name" value="Sod_Cu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00068">
        <property type="entry name" value="CUZNDISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49329">
        <property type="entry name" value="Cu,Zn superoxide dismutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00087">
        <property type="entry name" value="SOD_CU_ZN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00332">
        <property type="entry name" value="SOD_CU_ZN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="6 9" id="KW-0186">Copper</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="Superoxide dismutase copper/zinc binding" evidence="11">
        <location>
            <begin position="59"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PCH39797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="198" mass="20286" checksum="4B42CB22D0565B5F" modified="2018-01-31" version="1">MDGQLQRARQSKQPVALAVLGTLAFSILFWIAFLRPSSAPDVPVITQAVAVLKGDSGASGTVTFVQTAPTASVTITGELRGLDPKARRGFHIHTSGDLSSGCASAGVHFNPLRQTHGAPSAPVRHVGDLGNIESDGQGVARFTIEDKLVSLNGLLSVVGRAVVLHTGTDDLGEGNNEESLRTGNAGARAACGVIGISG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JUM0</accession>
    <name>A0A2H3JUM0_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HIG1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WOLCODRAFT_137446</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH41528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JUM0"/>
    <dbReference type="STRING" id="742152.A0A2H3JUM0"/>
    <dbReference type="OMA" id="KIITATW"/>
    <dbReference type="OrthoDB" id="1915122at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd15457">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.40">
        <property type="entry name" value="YbiA-like"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="YbiA-like"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADAR" evidence="2">
        <location>
            <begin position="151"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="126"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08719"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH42128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="295" mass="34393" checksum="8B2448941F8044F6" modified="2018-01-31" version="1">MHTHSQPIGVTTESRSYHPQSVIDPNTGATVQYVIQEERHRTIYVASPVPPDQLHPQTMSRLFESADDLQRRYEGSRKRRRAESLQSSSVRNGTRYDLAYQSSPTRSEPAFSKPPSPINTFKRSSFPHYTYNTPPSPIKSSQPPPRRQILFYHKHEPYYEFTNFSPHPVTYKGKVYPTSEHLFQSFKFLEHRPYLAEHIRTCSDRPSVAFSEARRFQPEVRHDWLSVNVQKMDDALWHKFTQHDSLKRKLLATGDAELIENSDRDAFWGIGADGKGRNELGKALERLRTRLRNNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JWV9</accession>
    <name>A0A2H3JWV9_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4939 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WOLCODRAFT_159723</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468105">
        <property type="protein sequence ID" value="PCH40657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="DUF4939"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4939" evidence="3">
        <location>
            <begin position="152"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="111"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="250"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PCH40657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="288" mass="33785" checksum="0EF9F99AA9A4F4BD" modified="2018-01-31" version="1" fragment="single">MPMEIRISLRAPQEWQELRASEMMERILEALQEQIIARPEDRTLLDLYLLLRRVGLGLWLEEQTSSQVSDRPHPEWVAEEICLGLQEAEEWGQQPQEHGLPAFLQEPPQVRAEEDWEETSDSEEGIPPLEDSDSEETPLLPEETQVEEIQEDHPDPYYRTPMIKINPPDVFDGERSDMQNFINQCNSWFTMYETSFQNDIQRVIFILSYISGKGKTGQWKQNYHRVHTDPTTRRFFPPSLVQFDADFQKAFGAVQEIQKARRQILKLEQDKKDIDDYITEFNNMAGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JXL0</accession>
    <name>A0A2H3JXL0_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA-directed RNA polymerase subunit</fullName>
            <ecNumber evidence="12">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">WOLCODRAFT_163115</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
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                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="12"/>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH41464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="742152.A0A2H3JXL0"/>
    <dbReference type="OMA" id="NREDYQQ"/>
    <dbReference type="OrthoDB" id="270392at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02735">
        <property type="entry name" value="RNAP_I_Rpa1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01435">
        <property type="entry name" value="RNAP_I_RPA1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000019">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.274.100:FF:000006">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.180:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.120:FF:000006">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.390">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.180">
        <property type="entry name" value="RNA polymerase ii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="entry name" value="RNA polymerase II, clamp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="entry name" value="RNA polymerase Rpb1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047107">
        <property type="entry name" value="DNA-dir_RNA_pol1_lsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015699">
        <property type="entry name" value="DNA-dir_RNA_pol1_lsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376:SF11">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
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                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH41787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="742152.A0A2H3K036"/>
    <dbReference type="OMA" id="RSECASR"/>
    <dbReference type="OrthoDB" id="2804215at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
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        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="36"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH41787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="324" mass="36293" checksum="B3E22ADEA564B6D1" modified="2018-01-31" version="1">MPTGVINTSFRILKRLCERDHYLPRSCVLPQESITMESPIPIAFGGFGEVFRAEYKTPDGSMDVAVKRYRLTPQKDSQRTRKDFCREVVVWRHLKHRNVGEFLGTHNNTQTRMSLVSKWMPNGSIKNFIKRVPTANRLQLISGTASGLAYLHSQRVIHGDLKDDNVVVDESGDARLIDFGLTTILHTADTENMITTLHTATGPGIRGTVHWMAPELFNPEAFELKSSMPSAASDIYALALVMWGVFSLQVPFHQYPLSATVIFNVLNGARPSRPEGTKELGLSDMLWDFINECWAANPADRPSIDTILNKLHALDEDSATIRST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K0E7</accession>
    <name>A0A2H3K0E7_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin 3 binding protein But2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_139119</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468168">
        <property type="protein sequence ID" value="PCH44639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K0E7"/>
    <dbReference type="STRING" id="742152.A0A2H3K0E7"/>
    <dbReference type="OMA" id="DWGMENC"/>
    <dbReference type="OrthoDB" id="3350619at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018620">
        <property type="entry name" value="Ubiquitin3-bd_protein_But2_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09792">
        <property type="entry name" value="But2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin 3 binding protein But2 C-terminal" evidence="2">
        <location>
            <begin position="150"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH44639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="286" mass="32137" checksum="91DE78CC6B600846" modified="2018-01-31" version="1">MQAFRRAEYILLATTDSPSSERISIDPEDTKQIQLRSVGSDLHSRLVFWACVSAICSSILSLCVAGYGYLSTPANVLGQSRNIKPLRRPNPYINLDKVLKDSNETFPPIVNFPPIVLQTAASGPRRTMREDHRQQRTKYGTVYPDERHILITSETSTIVQFRNIDYAMERCVLTLSLPPSVSLPDVPIKFSDPSTVDVWFLDTTSEISPYVSSTWEYAPSRLELLSTLEFSRGGPTNSTEFRCPSNEFTTFELVCTIPGCEVDFWQDRTVTPKGGVYLTQHQSVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K0J1</accession>
    <name>A0A2H3K0J1_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">LAG1-DNAbind-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WOLCODRAFT_26063</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Su(H) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468146">
        <property type="protein sequence ID" value="PCH43618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K0J1"/>
    <dbReference type="STRING" id="742152.A0A2H3K0J1"/>
    <dbReference type="OMA" id="CPPRVVI"/>
    <dbReference type="OrthoDB" id="5600360at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1450:FF:000003">
        <property type="entry name" value="Related to J kappa-recombination signal binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1450">
        <property type="entry name" value="LAG1, DNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015350">
        <property type="entry name" value="Beta-trefoil_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036358">
        <property type="entry name" value="BTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040159">
        <property type="entry name" value="CLS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015351">
        <property type="entry name" value="RBP-J/Cbf11/Cbf12_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037095">
        <property type="entry name" value="RBP-J/Cbf11_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038007">
        <property type="entry name" value="RBP-Jkappa_IPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10665">
        <property type="entry name" value="RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09270">
        <property type="entry name" value="BTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09271">
        <property type="entry name" value="LAG1-DNAbind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20144">
        <property type="entry name" value="TIG_SUH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01268">
        <property type="entry name" value="BTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01267">
        <property type="entry name" value="LAG1_DNAbind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110217">
        <property type="entry name" value="DNA-binding protein LAG-1 (CSL)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
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                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468157">
        <property type="protein sequence ID" value="PCH44114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K4Y9"/>
    <dbReference type="STRING" id="742152.A0A2H3K4Y9"/>
    <dbReference type="OMA" id="FEMERIN"/>
    <dbReference type="OrthoDB" id="10261027at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF140">
        <property type="entry name" value="INACTIVE PROTEIN TYROSINE KINASE PTKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="293"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH44114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="582" mass="65998" checksum="BE6555574596FF40" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K5I4</accession>
    <name>A0A2H3K5I4_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WOLCODRAFT_74936</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="KB468146">
        <property type="protein sequence ID" value="PCH43687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K5I4"/>
    <dbReference type="STRING" id="742152.A0A2H3K5I4"/>
    <dbReference type="OMA" id="YYGCFLD"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000499">
        <property type="entry name" value="Serine/threonine-protein kinase KIC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF21">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="10"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PCH43687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="327" mass="36403" checksum="35D6B1D040C1E4F4" modified="2018-01-31" version="1">MPQPSVHQLYRRLETVGKGAYGSVHKGVEIQTGNVVALKIINLDTEDDDVGDIQREVALLTQLRDAPNVTQYYGCFLDGPRVWIIMEYAQGGSVRTLMKASKDGVIEEKYAAVITREVLLGLSYLHKSAIIHRDLKAANILVTAAGKVMICDFGVSALLVTASSKRNTLVGTPHWMAPEVAHASAYDTKADIWSLGIMIYEMIKGSAPNSHVVDQAKLLQMLPRMKPPRLIEGEGSKELREFVSLCLRESPADRLTADELSKTKWIKSVAKTPLTILKDLIIRYEAWTKSGGTRASMADPLPWEEEEREYVCLVFRKRIIINCPVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K6D4</accession>
    <name>A0A2H3K6D4_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_168104</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468152">
        <property type="protein sequence ID" value="PCH43997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K6D4"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="145"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH43997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="181" mass="19959" checksum="8F50B2AC7AFC231E" modified="2018-01-31" version="1">MASGTARADMLAVLCLPRRPLSMHAAPRPLCYCYRRVASSDRPQRLPSVTPSRPPLPAPRPHWPRYIEVGVQHSPPGFGGARANSASLQWTTARILPAPRRQRDWNKYGVQLRPVGAIGDTVRPVLPADQWPHRAAHQPHLAALRMQTRARPSPRTPSDTDTYEVHELDATRAAGGAELGL</sequence>
</entry>
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    <accession>A0A2H3K6S3</accession>
    <name>A0A2H3K6S3_WOLCO</name>
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            <fullName evidence="6">Kinase-like protein</fullName>
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        <name evidence="6" type="ORF">WOLCODRAFT_104642</name>
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        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
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        <lineage>
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            <taxon>Phaeolaceae</taxon>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD-104</strain>
        </source>
    </reference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Prot_kinase_dom"/>
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        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
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    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF288">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
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        <location>
            <begin position="1"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PCH44137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="244" mass="27637" checksum="6E41D7A970125329" modified="2018-01-31" version="1">MPVAEDEQRKKINALLMKEIIVWRVVHHPNILPFNGVCEVGQPKILWMVSPWMQNGDIARYIKNNPGADRLKLSVEIVQGLDYLHSTMRIFHGDLKGPNILVDDDGHARLADFGTSRVKLEIAEATGSRSTQSRSIHYLAPERHNPELFGQTSSLPTFHSDLYSLSVVLWELFAGQNPYEGASDGHIMTTVVKGERPKRIPKLRENGMPDGLWPIIEECWDNDFNKRPPTSQVRTRVESLIGPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3ISP3</accession>
    <name>A0A2H3ISP3_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WOLCODRAFT_61848</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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        </lineage>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD-104</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ustYa family.</text>
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    <dbReference type="EMBL" id="KB467831">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="742152.A0A2H3ISP3"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="TAT PATHWAY SIGNAL SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PCH33000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="161" mass="17878" checksum="9DF5B4ADFD673907" modified="2018-01-31" version="1">MHSSEITVLTGTVHLGYIGQEFPSELPLRLGNVAMSFETMPMNGHYSQTGFNAWLEWHAIDHFPKAHGFVALGANGRQFGISMFHQLHCLEMIRESMINGPDGHAAHCLNFLRQAILCNSDITLESGGESTHVCRDWTQVYAFVTRNQLSSSWPTSNSSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
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    <protein>
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            <fullName evidence="1">Uncharacterized protein</fullName>
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        <lineage>
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            <taxon>Agaricomycetes</taxon>
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            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="PCH33272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3ITG1"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH33272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="210" mass="23768" checksum="12CCE31C5384CCD8" modified="2018-01-31" version="1">MPTVLLEHEYLDKPPNLIQCNGASRRHVQSFRKHERPRQPPTQAVIGVRAKGAFERLQQGELLPIIAEAQQRLESPGWDVLRPALAVILRKVAGNCMKPPQVPRRPEVQAGGILDKAQDVDREFNGPLGKPPQVGGVIYPGWVSISKDSYLRMLSPHATSNLILTRAELRRYEVPLQSDSPPTWKKWQLARRIKPKLASGRYVPRCWTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IU24</accession>
    <name>A0A2H3IU24_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_147575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="10347455at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <location>
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            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="409"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="466"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH33480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="482" mass="49153" checksum="7346DF13EE073F20" modified="2018-01-31" version="1">MHLLYTIALLPRRLSRRRLHTLSHSVHAGSHRCRSRVLESQSSSIVIPARPRSHLDDRQCTPENGRYLAIFGLNVQYSTVNHLGLVFIRPKHSDSVASLLFSHFHTIQNVDMRSPVVAFSLFAAAAVSVSAGGLPKSHELNALSPPASLNKDSGGARALTNEPRADSVGLGIAGIARDSAGAISHNERLHGDGRVDGAGRDDGRPQRDERPQKPGVPYGDGNSGNGCTVGNPTADATEVENGALTAIDDSGTNGGVSCSGDVHAGNADGSPGSGNAASPDAGPASGSDVYNKGVADLLGTQGQSGGTSESASASGGDPASMNEAEQGPVFVNGYPTYASGGATPARRSITTLSAEQARTSLFDVVNATTGQAQAPSSDSIVRRFVKVRREPTELFPYDPSTVVYGDDDAGDGTSGDCVRGAEIPGQGTRDHPGGTATSGTVGPCDNGSVIEHGNVVDGDGASNTPGAGGRSESGTAVGGDGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IUB0</accession>
    <name>A0A2H3IUB0_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">3'-5' exonuclease</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Werner Syndrome-like exonuclease</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WOLCODRAFT_147401</name>
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    <organism evidence="12 13">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH33301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3IUB0"/>
    <dbReference type="STRING" id="742152.A0A2H3IUB0"/>
    <dbReference type="OrthoDB" id="1920326at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06141">
        <property type="entry name" value="WRN_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051132">
        <property type="entry name" value="3-5_Exonuclease_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13620:SF109">
        <property type="entry name" value="3'-5' EXONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13620">
        <property type="entry name" value="3-5 EXONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00474">
        <property type="entry name" value="35EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3'-5' exonuclease" evidence="11">
        <location>
            <begin position="46"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="250"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="261"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="306"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="377"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="432"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
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        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="10">
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        </location>
    </feature>
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        </location>
    </feature>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00042761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PCH33301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="657" mass="71863" checksum="95D30A44BA55F072" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IUI2</accession>
    <name>A0A2H3IUI2_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 16">DNA topoisomerase 2</fullName>
            <ecNumber evidence="5 16">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">WOLCODRAFT_134889</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="20 21">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14 16">Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks.</text>
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            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
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            <name>Ca(2+)</name>
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        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="16">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the type II topoisomerase family.</text>
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        <location>
            <begin position="529"/>
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    <feature type="domain" description="Topo IIA-type catalytic" evidence="19">
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    <sequence length="1583" mass="176487" checksum="3A35483A1A64E81B" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IV64</accession>
    <name>A0A2H3IV64_WOLCO</name>
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        <recommendedName>
            <fullName evidence="4">aminodeoxychorismate synthase</fullName>
            <ecNumber evidence="4">2.6.1.85</ecNumber>
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        <alternativeName>
            <fullName evidence="8">Para-aminobenzoate synthase</fullName>
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        <alternativeName>
            <fullName evidence="9">p-aminobenzoic acid synthase</fullName>
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    </protein>
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        <name evidence="14" type="ORF">WOLCODRAFT_94409</name>
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    <organism evidence="14 15">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>chorismate + L-glutamine = 4-amino-4-deoxychorismate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:11672"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58406"/>
            <dbReference type="EC" id="2.6.1.85"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 4-aminobenzoate from chorismate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the anthranilate synthase component I family.</text>
    </comment>
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    <dbReference type="STRING" id="742152.A0A2H3IV64"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:L-tryptophan biosynthetic process"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ADC_synthase"/>
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        <property type="entry name" value="Anth_synth_I-like"/>
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        <property type="entry name" value="Anth_synth_I_N"/>
    </dbReference>
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        <property type="entry name" value="Chorismate_C"/>
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    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010117">
        <property type="entry name" value="PabB_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006221">
        <property type="entry name" value="TrpG/PapA_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01823">
        <property type="entry name" value="PabB-fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00566">
        <property type="entry name" value="trpG_papA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236">
        <property type="entry name" value="AMINOBENZOATE/ANTHRANILATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236:SF18">
        <property type="entry name" value="AMINODEOXYCHORISMATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04715">
        <property type="entry name" value="Anth_synt_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00097">
        <property type="entry name" value="ANTSNTHASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00099">
        <property type="entry name" value="CPSGATASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00096">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="ADC synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="7" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="11">
        <location>
            <begin position="10"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Anthranilate synthase component I N-terminal" evidence="13">
        <location>
            <begin position="275"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="Chorismate-utilising enzyme C-terminal" evidence="12">
        <location>
            <begin position="462"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="434"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PCH33890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="765" mass="84408" checksum="67FE1120B4CA2A4D" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IVA1</accession>
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    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_93906</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Agaricomycetes</taxon>
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            <taxon>Phaeolaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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        <location>
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            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="412"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH33651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IVD1</accession>
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        <recommendedName>
            <fullName evidence="6">HIG1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="7" type="ORF">WOLCODRAFT_160477</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="PCH33950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="1915122at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007667">
        <property type="entry name" value="Hypoxia_induced_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040153">
        <property type="entry name" value="Rcf2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28018">
        <property type="entry name" value="RESPIRATORY SUPERCOMPLEX FACTOR 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28018:SF3">
        <property type="entry name" value="RESPIRATORY SUPERCOMPLEX FACTOR 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04588">
        <property type="entry name" value="HIG_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51503">
        <property type="entry name" value="HIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="HIG1" evidence="6">
        <location>
            <begin position="90"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PCH33950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="206" mass="23218" checksum="10E83D09C5368821" modified="2018-01-31" version="1">MKIATEEELAGHYAAIVRGAIEGIAAGLAISLPGTWYMNHRWLAFRSLPIQLKALGTVLLVAPLYAIQAERRGVEYDESTWTGAGKRELEREERRQQERWSTLDAGQKFREWAMRHQYEVILGSWATSMAIAGAIVMRNKHQTTSQKVVQARMWAQGLTIGVLIAAGVLTHSNRQEAAANRQVDHTWVNMVEEFQREEIARASSHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IVT0</accession>
    <name>A0A2H3IVT0_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">T-complex protein 1 subunit eta</fullName>
            <shortName evidence="9">TCP-1-eta</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">CCT-eta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WOLCODRAFT_135484</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterooligomeric complex that forms two stacked rings.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
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        <property type="protein sequence ID" value="PCH34066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03340">
        <property type="entry name" value="TCP1_eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000017">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.260.10:FF:000022">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000006">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012720">
        <property type="entry name" value="Chap_CCT_eta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02345">
        <property type="entry name" value="chap_CCT_eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="528"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="550"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PCH34066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="560" mass="60790" checksum="1535FCAFD7205C88" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IY11</accession>
    <name>A0A2H3IY11_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_27331</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467832">
        <property type="protein sequence ID" value="PCH34621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3IY11"/>
    <dbReference type="STRING" id="742152.A0A2H3IY11"/>
    <dbReference type="OMA" id="AIAFNNM"/>
    <dbReference type="OrthoDB" id="3259156at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH34621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="583" mass="62542" checksum="B17165B52D821F9E" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IY65</accession>
    <name>A0A2H3IY65_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pyridoxamine 5'-phosphate oxidase Alr4036 family FMN-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_135682</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH34385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3IY65"/>
    <dbReference type="STRING" id="742152.A0A2H3IY65"/>
    <dbReference type="OMA" id="LAWWIEG"/>
    <dbReference type="OrthoDB" id="434253at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024624">
        <property type="entry name" value="Pyridox_Oxase_Alr4036_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28243">
        <property type="entry name" value="AGL049CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28243:SF1">
        <property type="entry name" value="PYRIDOXAMINE 5'-PHOSPHATE OXIDASE ALR4036 FAMILY FMN-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12766">
        <property type="entry name" value="Pyridox_oxase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyridoxamine 5'-phosphate oxidase Alr4036 family FMN-binding" evidence="1">
        <location>
            <begin position="6"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH34385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="232" mass="26417" checksum="C46F97F1159948E3" modified="2018-01-31" version="1">MPSVPRWIDSVVKALGLPENKGQNVFQMATVDASGKPKVRTLVHRELFQPSGRPNLPVILTTTDVRSPKVQELRANPYAELCWWMEGSKDQFRISGPVRVIPSPHADRTAWVKGEPSVAFDVVEEQGFDWEKKRSEVFDNMSAHMKASWCRPPPGSVLQSYQEAKKWTGKVPKLGEAESEDDRRNQEQALQNFALVLIEAVEVDWVQLGEQPNRRTRFLRVGEEWTEEISVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J001</accession>
    <name>A0A2H3J001_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_107523</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467854">
        <property type="protein sequence ID" value="PCH35570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J001"/>
    <dbReference type="OMA" id="HIIREHN"/>
    <dbReference type="OrthoDB" id="6511194at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35871:SF1">
        <property type="entry name" value="CXC1-LIKE CYSTEINE CLUSTER ASSOCIATED WITH KDZ TRANSPOSASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35871">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH35570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="493" mass="57013" checksum="E4A84A5BBB94581B" modified="2018-01-31" version="1">MQGYGEHYARNLHTWICQYMTDNKLPLHRYGNCSTSVLDDEDIAQSIQLRLLEKASTSYVRTQDVVEIVATPEIQDKLEYGAMRTTITVRTAQRWLRKLDWRYRRKSNGMYVDGHERDDVVEYRSTFVKRWAEYEKRMVTYNNDGNISTTPKGFPIPDGRFRLYLVTHDESTFYANDRRKTKWIHSSEKSAPQRKGEGASLMVSDFLTPDWGPLIHGNQAARLIWKAGTNRDGWFGAEDLLKQVEIAIDLFEAKTNGWAVGLWMFDNAPSHQRRAADALSARRMPKGPKAGWTHRKDGPKMRNGTFPDGSSQALYFPDDHPVMPGWFKGMEHIIREHNLWPANGLKAQCDGFKCPSGQADCCCHRLLFTQPDFIDQKSQLEEYITSRGHLCDYYPKYHCELNFIEQYWGHAKMHYRTSPQTSDINEMEQNVLRCLDNVSLLSIRRYANRSARFISAYAQGLSGAEAVWANRKYHGHRTLPPALAAELKREARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J0P6</accession>
    <name>A0A2H3J0P6_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PCI-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WOLCODRAFT_139836</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467843">
        <property type="protein sequence ID" value="PCH35275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J0P6"/>
    <dbReference type="STRING" id="742152.A0A2H3J0P6"/>
    <dbReference type="OMA" id="AKVYFYF"/>
    <dbReference type="OrthoDB" id="1713558at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042176">
        <property type="term" value="P:regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050756">
        <property type="entry name" value="CSN3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
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        <property type="entry name" value="PSMD3_C"/>
    </dbReference>
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        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="TPR_PSMD3_N"/>
    </dbReference>
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        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758:SF2">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3/COP9 SIGNALOSOME COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08375">
        <property type="entry name" value="Rpn3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25573">
        <property type="entry name" value="TPR_PSMD3_N"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="256"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH35275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="510" mass="57400" checksum="90EBB4F20A8B4453" modified="2018-01-31" version="1">MADVEMKPIDEAKKPSDEETKKEDESKAPKPVSPAAEIKSNVALIERAVSSLEPRFTHRVLRTLTALRKKLDERVLREAIESVYTHPDSQTKKTLLAWVPAASAGEQSMDVDSTPASAPAQKHGQQEPVPEGEIYLRLLILHYLLATPNTHKQAMELAHETVQRMQSLNRRSMDPIAAKVWYAVERTYELGGQLADARPLFLSAQRTASLRHDDETQASLINRLLRSYINYNLYDQADKLVSKTSFPASAGNPQFARYHYYLGRIKAVQLNYTAAHTNLQQAIRRAPLAKTAPGFYQAVHKLSVVVDLLMGEIPERSLFRQPVLEKALSGYFEIVKAVRMGSLSQFQSTLSKHAAAFEADKTYTLIVRLRQNVIKTGIRRLSLSYARISLRDICVKLHLDSEEDAEYIVGKAIRDGVIEGRIVHEKGWMECGSQKSGYGPEVSEVFTRRIQYCLELHNQSVKAMRYPLNAHRKELAAAENAREREKELAKDIYEGGGDFEDDGPDIGEGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J0Y9</accession>
    <name>A0A2H3J0Y9_WOLCO</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_156057</name>
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    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467843">
        <property type="protein sequence ID" value="PCH35365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J0Y9"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH35365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="59" mass="6593" checksum="3A1ECB1BF89295E2" modified="2018-01-31" version="1">MPTQWDFDAAPCRPIPTTKRSCFSRGNPFVRTSATWSPVAYPNVLCTLVENRVLGEHNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J1M7</accession>
    <name>A0A2H3J1M7_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_146135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467865">
        <property type="protein sequence ID" value="PCH36160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J1M7"/>
    <dbReference type="STRING" id="742152.A0A2H3J1M7"/>
    <dbReference type="OMA" id="GDMRDEG"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="1">
        <location>
            <begin position="32"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH36160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="481" mass="52997" checksum="34F48765CBDCB588" modified="2018-01-31" version="1">MVYKALTWLALTTLQQFRFITSDSLPDSLPESPTIALPYGNLQGSTLGDVSSFLGIPYAQPPLGDLRFAPPQPPLLFKGVAQATEFGPACPQQIPKLPNVLPFNVSVPVFKDSMSEDCLFINVYKPASARAQDKLPVVFWIFGGAFEFGDAALYPATAFVKRSMELGEPVIFVSHNYRVNAFGFLASQEVVDAGHTNIGLRDRHNQPALYANLILCCRWGTKLGFLESGTPAVLQPYTEGGPYYDVLVEHAGIMAGVNATPNADSYRSMNLAWQPRLDADMTDAQFLKYVRSTYMPAATSSDLQKVSKSYPSDPGEGSPFGTGDLYALTPQYKRIAAFTGDWEFVAPHRFWVEHMSRTQDTWAYLFNRMKSTPFLGAVHSSDVTEFFGDRNNFPSGTDRCIDFAATDAIINFANHLNPNAPAGLPSNVSFLSKVSWDKWSEGTTSHPFLLFLDPAPSLGLSYDMYRADALALLNRIALKMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J1W6</accession>
    <name>A0A2H3J1W6_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphatidylglycerol/phosphatidylinositol transfer protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WOLCODRAFT_135322</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the intermembrane transfer of phosphatidylglycerol and phosphatidylinositol.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NPC2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH33783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH36591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="235" mass="25195" checksum="6DC6D1A605179016" modified="2018-01-31" version="1">MHDYKHAERPAGQHQAASPPVPTPAPQPYQYGVVGRPLPAGTTVNVPHTPDPSRSHSPSVLTSYSPPPSASFRTSITPLPGARTAITPGPSIASSSRASTPGLVPAYPSQLQQYHHELQQQQYQQQYQSQQARLSWPRYGGSEDGYDERRSPAQRARSERRPSRLSLTLANWNPETDGELGDIGVQEIDSSGGPTEVTVEETSQTGWSQSAASSAGDVQRRADSGPPEAPSNAPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J507</accession>
    <name>A0A2H3J507_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_158057</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467920">
        <property type="protein sequence ID" value="PCH37332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J507"/>
    <dbReference type="STRING" id="742152.A0A2H3J507"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH37332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="286" mass="30756" checksum="A6305A59AB9BDFCF" modified="2018-01-31" version="1">MEQDASNSEEDEENKEDQMGREEEEKSGRAETDGSVAAAFQRLQHNDDMEMDGEGEVPRQLTRVAEHERRETSQAPQASVHVQAEQPSADNEGRYSRYHSQVGDDQDDLLKAVTQMSGMLHQLVHKVDVLQETVHEMQVGQVGLQTQLEALRQVALGVPLATSTTTAPAPLATSVTAVPLLPTRLTTPPPMPLTMPPPVHLMTPPDAPHVPDMTLATSTTMAPAPLATSVTAVPLLPARLVTLPPAHLVTLPPMHSAMPPDAPDVPDVALATTATMALTRESVRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J5B5</accession>
    <name>A0A2H3J5B5_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ceramide glucosyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.80</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Glucosylceramide synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">UDP-glucose ceramide glucosyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">UDP-glucose:N-acylsphingosine D-glucosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">WOLCODRAFT_62794</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">MD-104</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.80" evidence="5"/>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH33939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J5B5"/>
    <dbReference type="STRING" id="742152.A0A2H3J5B5"/>
    <dbReference type="OMA" id="IVWIIDC"/>
    <dbReference type="OrthoDB" id="1483400at2759"/>
    <dbReference type="UniPathway" id="UPA00222"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008120">
        <property type="term" value="F:ceramide glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006679">
        <property type="term" value="P:glucosylceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02520">
        <property type="entry name" value="Glucosylceramide_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025993">
        <property type="entry name" value="Ceramide_glucosylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12726">
        <property type="entry name" value="CERAMIDE GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12726:SF0">
        <property type="entry name" value="CERAMIDE GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13506">
        <property type="entry name" value="Glyco_transf_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PCH33939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="468" mass="52076" checksum="D5F159AB87486BC2" modified="2018-01-31" version="1">MAESVTDYGTLRSTLASASIAWYAVLWSLGLLGCRTARKRYRCRPRSPLASAPVSSVPGVSILRPLKGLDTNLYENLESTFTQEYPNYEIFLCVADEHDQALSVVRDLIAKYPNVNAHVTIGTSHSQQEVVGVNPKINNLIRSYRQAANDIIWVLDSNVMVDPGTLARSVEALDGPADLPATSSSRRRIALVHHVPFAWSSEAFGSRLDEAFLNTNHAKMYLAINTVAIDSCVVGKSNLYRRSDVERVDGSLKPMSNAAEAGSQPGQRGLAAFGRFLAEDNMIAGALWHELGLRHELSCDVARNAVGNMSLSDYIWRRVRWIRVRKRMVFAATMIEPLTESVVLGILTSIGAKYLFGIPQWLFLPLHFLLWLCVDLDVSASLAGHPVPPSSRWAFVGSWAVRELLAFPIWLLAIVGSQVEWRGQQYKVTRNGEVRKVSRANVTGLFGWFSRQFNKEARAGYEQLELQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J5H4</accession>
    <name>A0A2H3J5H4_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytochrome b-c1 complex subunit 8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Complex III subunit 8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WOLCODRAFT_109965</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="12 13">MD-104</strain>
        </source>
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        <text evidence="11">Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The complex plays an important role in the uptake of multiple carbon sources present in different host niches.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein, 2 core protein subunits, and additional low-molecular weight protein subunits. The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with cytochrome c oxidase (complex IV, CIV).</text>
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            <location evidence="1 11">Mitochondrion inner membrane</location>
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</entry>
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    <accession>A0A2H3J5V6</accession>
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            <fullName evidence="3">Vacuolar membrane-associated protein IML1</fullName>
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            <fullName evidence="4">Vacuolar membrane-associated protein iml1</fullName>
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        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
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    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
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                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
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                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
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                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
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                <person name="Stenlid J."/>
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            <dbReference type="DOI" id="10.1126/science.1221748"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7 8">MD-104</strain>
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        <subcellularLocation>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50186"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH37632.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="1544" mass="173973" checksum="0BEFB42A8A4336A5" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J5Z5</accession>
    <name>A0A2H3J5Z5_WOLCO</name>
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        <recommendedName>
            <fullName evidence="3">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_140707</name>
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    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
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                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
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        <source>
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                <person name="Barry K."/>
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                <person name="Kallen N."/>
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    </evidence>
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            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
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                <person name="Heitman J."/>
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                <person name="Kallen N."/>
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                <person name="Kohler A."/>
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                <person name="Kumar T.K.A."/>
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                <person name="Lindquist E."/>
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                <person name="Nagy L.G."/>
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                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
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                <person name="Sabat G."/>
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            <strain evidence="7 8">MD-104</strain>
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    </evidence>
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        <source>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD-104</strain>
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    <comment type="similarity">
        <text evidence="9">Belongs to the adaptor complexes medium subunit family.</text>
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    </dbReference>
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        <property type="entry name" value="CLATHRINADPT"/>
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        <property type="entry name" value="SNARE-like"/>
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        <location>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <sequence length="426" mass="48006" checksum="BD8767411B0F6FC6" modified="2018-01-31" version="1">MISAFFIFNQKGEVLISRLYRPDLKRSIADVFRIQVVSNSDVRSPIITLGSTSFFHVRVNNLYVVAVTKCNANAALVFEFCYRFISIAKSYFGKVDEEAIKNNFVLIYELIDEINDFGYPQNSEIDTLKSYITTESVMSTNFAAEESSRITVQATGATSWRRNDVKYKKNEAFVDVVETVNLSMSAKGTILRADVDGHILMRAYLSGTPECKFGLNDKLVIDKEQRGASDAVELDDCRFHQCVRLNEFDSSRTISFIPPDGEFELMKYRSTSNVKLPLKVIPSVTEIGTTQVQYVVTVKTNFSNKLSGTNVVLRIPTPLNTTSVDCKVVSGKAKYVPAENVVVWKIQRIQGGQEVTLSATAALTSTTTRQVWARPPIDVDFQVLMFTASGLIVRFLKVFEKNNYQSVKWVRYLTKASGSYQIRVRF</sequence>
</entry>
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    <accession>A0A2H3J6W2</accession>
    <name>A0A2H3J6W2_WOLCO</name>
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        <recommendedName>
            <fullName evidence="7">CFEM domain-containing protein</fullName>
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        <name evidence="8" type="ORF">WOLCODRAFT_139918</name>
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        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
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    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD-104</strain>
        </source>
    </reference>
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        <subcellularLocation>
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        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
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    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
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            <begin position="9"/>
            <end position="127"/>
        </location>
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            <begin position="1"/>
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        </location>
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            <begin position="10"/>
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        </location>
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    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PCH35503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="186" mass="18120" checksum="3189A9213700B6FB" modified="2018-01-31" version="1">MAADSSSAVSTSFGSLSATSTSSNTVSYPSLGSYSTCVDDCFVQAISAAGCTSEVDVSCFCFGTNATAFTAKLTSCMAQYCPSSLASAESLSDKFCAVASPSTVLSFAITSIPSSTASSLLSSGSASGFSTTSAPSTTSTSASSTSGSATGSASTSAALRNTDTQLVMLSAGVGLAVLSAVFVAGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J702</accession>
    <name>A0A2H3J702_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Autophagy-related protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">WOLCODRAFT_87760</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Phaeolaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
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                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
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                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
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                <person name="Salamov A."/>
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                <person name="Slot J.C."/>
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                <person name="Stenlid J."/>
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                <person name="Sun S."/>
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            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out)</text>
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        <source>
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        </source>
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                <person name="Barry K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">MD-104</strain>
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                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
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                <person name="Kallen N."/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
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        </location>
    </feature>
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            <begin position="79"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH38711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="170" mass="18652" checksum="3BFCDE3B3776E114" modified="2018-01-31" version="1" fragment="single">MSGRQGGKVKPLKAPKKDKKELDEDDVAFKERKRLEEAALKAARDKAAKGKTCSSNNLLLTEDPVLAQVERQAAESRSPARSRQVQQSSYYTRTRAASATLLCEDDSLHVPLILPQLRGIACDTKETSSSCRNLLHLSDSLHFSIATAKGKALCTYPFRGILLATKPLTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J9X7</accession>
    <name>A0A2H3J9X7_WOLCO</name>
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        <recommendedName>
            <fullName evidence="5">Mini-chromosome maintenance complex-binding protein</fullName>
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        <name evidence="3" type="ORF">WOLCODRAFT_115930</name>
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        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">MD-104</strain>
        </source>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    </dbReference>
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    </dbReference>
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        <location>
            <position position="588"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH38721.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="588" mass="65037" checksum="73133B89C94C47BB" modified="2018-01-31" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JA18</accession>
    <name>A0A2H3JA18_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WOLCODRAFT_66883</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Phaeolaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
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                <person name="Ling A."/>
                <person name="Lombard V."/>
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                <person name="Lundell T."/>
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                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
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                <person name="Sabat G."/>
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                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
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                <person name="Cullen D."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD-104</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
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        <property type="protein sequence ID" value="PCH38761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="742152.A0A2H3JA18"/>
    <dbReference type="OrthoDB" id="2753961at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PCH38761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="141" mass="16396" checksum="06F45058FF750232" modified="2018-01-31" version="1" fragment="single">LSAFILTMVLNPEVLHEAQVEIDEVVSKERLPDFNDREKSLPYLECIIREVYQYSPPFPLGKFNMIRVEISTDVISGLIYHLISNDQYHGYHILQRTVAAPNMWSVPALYGTHNCHVHDKTNRAMSHNPQWYPNPEVFCLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JAJ3</accession>
    <name>A0A2H3JAJ3_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Pre protein translocase Sec Sec61-beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WOLCODRAFT_29264</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SEC61-beta family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467943">
        <property type="protein sequence ID" value="PCH38931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JAJ3"/>
    <dbReference type="STRING" id="742152.A0A2H3JAJ3"/>
    <dbReference type="OMA" id="SSGMWRF"/>
    <dbReference type="OrthoDB" id="5401193at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005784">
        <property type="term" value="C:Sec61 translocon complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030671">
        <property type="entry name" value="Sec61-beta/Sbh"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016482">
        <property type="entry name" value="SecG/Sec61-beta/Sbh"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13509">
        <property type="entry name" value="SEC61 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03911">
        <property type="entry name" value="Sec61_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PCH38931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="98" mass="10255" checksum="0256ACA1DD16AEE5" modified="2018-01-31" version="1">MSDSDAPRPTRANGASAVAKPTGAQNIRRRAAGSQVARPNSTRAAGAGGSSNTMLKLYTDDSPGLRVDPFIVLVLSLSFIASIFFLHISAKIVRALTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JBW6</accession>
    <name>A0A2H3JBW6_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WOLCODRAFT_141094</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="KB467954">
        <property type="protein sequence ID" value="PCH39075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JBW6"/>
    <dbReference type="STRING" id="742152.A0A2H3JBW6"/>
    <dbReference type="OMA" id="MESGAPW"/>
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    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013428793" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="20"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="27"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PCH39075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="551" mass="59592" checksum="1E6F926925D833FD" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JBZ8</accession>
    <name>A0A2H3JBZ8_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_23576</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468053">
        <property type="protein sequence ID" value="PCH39716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JBZ8"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH39716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="77" mass="8712" checksum="2259606C89AB15AD" modified="2018-01-31" version="1" fragment="single">MNFIVMIEQRQSLNNFEILCQACACKEVIVHCHLVGDLISHREERLSILVSVSPPHHQSLEDHIYSGLEIKSGLTNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JC48</accession>
    <name>A0A2H3JC48_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_135175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH33527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JC48"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH33527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="417" mass="43721" checksum="05A5ED6B8ABF312D" modified="2018-01-31" version="1">MVDTTRSLRVNPRPSSKMAALLEEGRRKGLHSIVKRTSTHSFRSNRKRPYCVFDGVELVSKRKRIAPQSSASAPASANHASIHAPGSLPGTSYAAAPPFVAPGRRASSASAATPPSASTRTSVSMTYTAHPSILRMRELAPAPSNQTSGARPRDSAVPARQNKGKRRAGGRAEDGAAIYPDAGTSRGPANGRHVAGAPPLSGSAGRRNSRAKRSTQISDALDDTPPPGLTVPQGGIPVPIDLNGLRVPSELQPLIDVVRRVLESEVELRQRAEARCAEEVQRRAAAEHLAEELRAANARLVDEARAWMQIAANPLASLSAPAQLSSGATYNGRAGLPSYGGAGHPGENAFRSVSRSGTPVPLQQNGAVTHADRKGKGRMVVPDGDVDPPPSAHEDQIMQYAAAVQQFLGCADSGAPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JC83</accession>
    <name>A0A2H3JC83_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit K</fullName>
            <shortName evidence="4">eIF3k</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">eIF-3 p25</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WOLCODRAFT_141699</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit K family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH33567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JC83"/>
    <dbReference type="STRING" id="742152.A0A2H3JC83"/>
    <dbReference type="OMA" id="GDDLCAD"/>
    <dbReference type="OrthoDB" id="337745at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006446">
        <property type="term" value="P:regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.250">
        <property type="entry name" value="ARM repeat, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03010">
        <property type="entry name" value="eIF3k"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033464">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009374">
        <property type="entry name" value="eIF3k"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016020">
        <property type="entry name" value="Transl_init_fac_sub12_N_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13022">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13022:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10075">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="5">
        <location>
            <begin position="49"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PCH33567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="248" mass="27638" checksum="71EAB8D565306218" modified="2018-01-31" version="1">MPSLASKWASPPTRTPLIENLVSGVDRYNPSNVSILEDYLYHQTRSEEYDCLANLAILKLYQFNPDLYNPDVVIYILIKALTSAPFPDFNLCISLLDERPAATNPDEPDPLPTLLPILTSLYNLLQQCRFPAFWALYRSDEAETLRDNYTVECVGFENAVREVVIRAVKAAFTRIGSERLGAYLDLSGGDLTAYVESLGWSIDPATEVIAVPPNPDNHIESTVVQENIQLPQLSKIITHATQNARGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JCG8</accession>
    <name>A0A2H3JCG8_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_19939</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467843">
        <property type="protein sequence ID" value="PCH35368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JCG8"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH35368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="145" mass="16376" checksum="4E7F1574EC932816" modified="2018-01-31" version="1">MVYPPESMFDDFVDVRSLVGGTTAATLCRHEIIRASLYGISCAQVLYYFWHYTEDHFLFKTLALWGYATKQFAQNSSWYCTATYNSSLFYDCYPLTQQASNWMPSTGPPDVRVAAESHLSAPVLSPVLFSAFMWPSSGKDSIPTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JCK3</accession>
    <name>A0A2H3JCK3_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RNA cytidine acetyltransferase</fullName>
            <ecNumber evidence="9">2.3.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">18S rRNA cytosine acetyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">NAT10</name>
        <name evidence="15" type="ORF">WOLCODRAFT_131132</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA-binding adapter protein TAN1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a cytidine in 18S rRNA + acetyl-CoA + ATP + H2O = an N(4)-acetylcytidine in 18S rRNA + ADP + phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51424"/>
            <dbReference type="Rhea" id="RHEA-COMP:13575"/>
            <dbReference type="Rhea" id="RHEA-COMP:13576"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:74900"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a cytidine in tRNA + acetyl-CoA + ATP + H2O = an N(4)-acetylcytidine in tRNA + ADP + phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53876"/>
            <dbReference type="Rhea" id="RHEA-COMP:13670"/>
            <dbReference type="Rhea" id="RHEA-COMP:13671"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:74900"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts with TAN1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
            <location evidence="1 9">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the RNA cytidine acetyltransferase family. NAT10 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="9"/>
    <dbReference type="EMBL" id="KB468053">
        <property type="protein sequence ID" value="PCH39926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JCK3"/>
    <dbReference type="STRING" id="742152.A0A2H3JCK3"/>
    <dbReference type="OMA" id="HLHYIMS"/>
    <dbReference type="OrthoDB" id="10067491at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990883">
        <property type="term" value="F:18S rRNA cytidine N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051392">
        <property type="term" value="F:tRNA cytidine N4-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904812">
        <property type="term" value="P:rRNA acetylation involved in maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051391">
        <property type="term" value="P:tRNA acetylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11040:FF:000002">
        <property type="entry name" value="RNA cytidine acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03211">
        <property type="entry name" value="RNA_acetyltr_Nat10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033688">
        <property type="entry name" value="NAT10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007807">
        <property type="entry name" value="TcmA/NAT10_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032672">
        <property type="entry name" value="TmcA/NAT10/Kre33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013562">
        <property type="entry name" value="TmcA/NAT10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027992">
        <property type="entry name" value="tRNA_bind_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10925">
        <property type="entry name" value="N-ACETYLTRANSFERASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10925:SF5">
        <property type="entry name" value="RNA CYTIDINE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13718">
        <property type="entry name" value="GNAT_acetyltr_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05127">
        <property type="entry name" value="NAT10_TcmA_helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08351">
        <property type="entry name" value="TmcA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13725">
        <property type="entry name" value="tRNA_bind_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TmcA/NAT10 N-terminal" evidence="12">
        <location>
            <begin position="12"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="TcmA/NAT10 helicase" evidence="11">
        <location>
            <begin position="277"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="13">
        <location>
            <begin position="534"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="domain" description="Possible tRNA binding" evidence="14">
        <location>
            <begin position="771"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="433"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1007"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="441"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1029"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1043"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="282"/>
            <end position="291"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="475"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="635"/>
            <end position="637"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="642"/>
            <end position="648"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="734"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF13725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PCH39926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="1054" mass="117524" checksum="9DFC3F959C649C49" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JD56</accession>
    <name>A0A2H3JD56_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_150219</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468053">
        <property type="protein sequence ID" value="PCH40180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JD56"/>
    <dbReference type="STRING" id="742152.A0A2H3JD56"/>
    <dbReference type="OMA" id="AWRPAHE"/>
    <dbReference type="OrthoDB" id="10000533at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051783">
        <property type="entry name" value="NAD(P)-dependent_oxidoreduct"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079:SF3">
        <property type="entry name" value="NAD-DEPENDENT EPIMERASE_DEHYDRATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079">
        <property type="entry name" value="PROTEIN YEEZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013796559" evidence="1">
        <location>
            <begin position="20"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="2">
        <location>
            <begin position="3"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH40180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="299" mass="32435" checksum="3956B838A6CD301D" modified="2018-01-31" version="1">MRVLIIGASGFIGLPVAQALVRAGHIVYGVTRSQAKVKQLAAEEIIPIVADTNNPGVWLPLVAKLDVVIEAIGGADVRTLSAALLKATAEAAQQYRPAGAPKLAYIYTSGCWVHGDNRNEIVTDTTPITKPIDLVAWRPQVEQLVATNPILNGIVIRPALLYGRSGSILAMLFKRAYEGQVAWYGTPGGRYSVIHCDDLADMYVRATEKSSIIGGKIFDVANDMTESVDDLLQKLVEVSGAQGPYQYVQSSNLFETAITTTTLLRPYLARALLGWQPRKASLVDHLDIYYNAWKASEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JD69</accession>
    <name>A0A2H3JD69_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ribosome biogenesis protein BRX1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WOLCODRAFT_135827</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BRX1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH37753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JD69"/>
    <dbReference type="STRING" id="742152.A0A2H3JD69"/>
    <dbReference type="OMA" id="YRHRHLM"/>
    <dbReference type="OrthoDB" id="1638493at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026532">
        <property type="entry name" value="BRX1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13634">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13634:SF0">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BRX1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Brix" evidence="6">
        <location>
            <begin position="45"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="265"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="265"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PCH37753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="302" mass="34447" checksum="736C323BF72B612E" modified="2018-01-31" version="1">MASVLKAQKINASKTDVKGKGKRKAEEIDEEDVQVPAPKKLKNKQRVLLLSSRGITHRMRHLMNDLEALLPHVKKDAKLDSKNHLHLLPELADLNNCNNTLYFESRRHEDLYLWAAKTPNGPSIKMHVQNVHTMDELKMTGNCLKGSRGILSFDKSFDESEWGRLTKEVFTHIFGVPQTARKAKPFIDHVLTFSVLDNKIWFRNFQIIEKDPLQPNGPPQMSMVEIGPRFVLTPIRIFEGAFGGATVYSNPEFVSPTAVRAALRGEKGEKYGKRKHAEQERSERKEGRRREEDELAVSKVFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JDG8</accession>
    <name>A0A2H3JDG8_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DUF862-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WOLCODRAFT_98633</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DeSI family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468053">
        <property type="protein sequence ID" value="PCH40280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JDG8"/>
    <dbReference type="STRING" id="742152.A0A2H3JDG8"/>
    <dbReference type="OMA" id="VTLQMAC"/>
    <dbReference type="OrthoDB" id="21221at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070646">
        <property type="term" value="P:protein modification by small protein removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.30">
        <property type="entry name" value="PPPDE domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008580">
        <property type="entry name" value="PPPDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042266">
        <property type="entry name" value="PPPDE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013535">
        <property type="entry name" value="PUL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378">
        <property type="entry name" value="DESUMOYLATING ISOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378:SF7">
        <property type="entry name" value="DESUMOYLATING ISOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05903">
        <property type="entry name" value="Peptidase_C97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08324">
        <property type="entry name" value="PUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01179">
        <property type="entry name" value="DUF862"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51858">
        <property type="entry name" value="PPPDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51396">
        <property type="entry name" value="PUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPPDE" evidence="6">
        <location>
            <begin position="2"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="197"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="PUL" evidence="5">
        <location>
            <begin position="346"/>
            <end position="661"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PCH40280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="664" mass="71304" checksum="E6195453272C056D" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JFI1</accession>
    <name>A0A2H3JFI1_WOLCO</name>
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        <recommendedName>
            <fullName evidence="6">2OGFeDO JBP1/TET oxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WOLCODRAFT_86477</name>
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    <organism evidence="7 8">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
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                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
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                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD-104</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
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        <property type="protein sequence ID" value="PCH40651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JFI1"/>
    <dbReference type="STRING" id="742152.A0A2H3JFI1"/>
    <dbReference type="OMA" id="CHITDQQ"/>
    <dbReference type="OrthoDB" id="2802946at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024779">
        <property type="entry name" value="2OGFeDO_JBP1/TET_oxygenase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12851">
        <property type="entry name" value="Tet_JBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2OGFeDO JBP1/TET oxygenase" evidence="6">
        <location>
            <begin position="121"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF12851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PCH40651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="279" mass="31599" checksum="D14DCAB33D0AF5BE" modified="2018-01-31" version="1" fragment="single">MLGSRPSGTNEILELRLERKWGPVQQGPPLEISRPSIIIDEHNKILAWCLPLVLSERRQVCVHLKFKKTPNDSAEEPSRGTSWRMDRRYFREWSQLELNSGVVNLSPGWHHQGHEVSPLDAYTCSLQSTNKQAGDKWLRDIQESSAILSGMMAVMHPDLHAAGQECMRRLAQNEDLKDTLQWWASIFNGAQIISNRVTPAHRDSKSRMQWYDLLASIGSYHNASLDLHGANISIKDGPGTVIALCGTAVRHSLMKYEGDRLCYAYFMRDSVHASMHVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JFN8</accession>
    <name>A0A2H3JFN8_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DUF1682-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WOLCODRAFT_131651</name>
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    <organism evidence="7 8">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Basidiomycota</taxon>
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            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH41010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="742152.A0A2H3JFN8"/>
    <dbReference type="OMA" id="MHLVRDM"/>
    <dbReference type="OrthoDB" id="10039147at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032469">
        <property type="term" value="P:endoplasmic reticulum calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012879">
        <property type="entry name" value="CCDC47"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12883">
        <property type="entry name" value="ADIPOCYTE-SPECIFIC PROTEIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12883:SF0">
        <property type="entry name" value="PAT COMPLEX SUBUNIT CCDC47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07946">
        <property type="entry name" value="CCDC47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="309"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="315"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="366"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PCH41010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="379" mass="42859" checksum="4E1C0DB5CCE71C8F" modified="2018-01-31" version="1">MSALLKLLTPPPVNVSPDYDGVEYQWRFLTFRPAFFQYEPYLLAGLLLYVALYFWGKRANDAAVKKWFDAHFPLLESQFSKPTENGLVKDGNSDWFNYSTGRRALASLHTTFTLRPRHDLLQYAFQIGRGLVELEYKVYDEVELDFTFRQPAGRESVVPDCVWAVVAKDEIKSIRSRRWDLTFTRTTDLPSLPPSLAVMSEYADVTDSLLKPIGALNLPAVLSDPAVLPYFRSLSLTDQPRTRPAVPLAPGERTKRLILTLALPPPAHAAATVPLLAAALQLVDAVAGEGRAPLRGGLNAQLRPETRVKLRRAREKVDEEIREDAAREKREEQEEKKAAAKRKAQEEKLSRLSAAEQQKALEREKKRALRKTQGKVKVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JFR7</accession>
    <name>A0A2H3JFR7_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WOLCODRAFT_139609</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD-104</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGG/PIGN/PIGO family. PIGO subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="PCH34837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="term" value="C:endoplasmic reticulum membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:mannose-ethanolamine phosphotransferase activity"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:GPI anchor biosynthetic process"/>
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        <property type="project" value="UniProtKB-UniPathway"/>
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    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
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    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="24"/>
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    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="426"/>
            <end position="445"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
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            <begin position="465"/>
            <end position="484"/>
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    <feature type="transmembrane region" description="Helical" evidence="11">
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            <end position="511"/>
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    <feature type="transmembrane region" description="Helical" evidence="11">
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            <end position="567"/>
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    <feature type="transmembrane region" description="Helical" evidence="11">
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            <begin position="574"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="616"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="648"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
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            <end position="718"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="11">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="948"/>
            <end position="971"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008695"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PCH34837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="998" mass="107897" checksum="72A9EA68BF4446E8" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JH68</accession>
    <name>A0A2H3JH68_WOLCO</name>
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        <submittedName>
            <fullName evidence="11">COPII-coated vesicle protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WOLCODRAFT_70392</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the EMP24/GP25L family.</text>
    </comment>
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        <property type="protein sequence ID" value="PCH41231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="entry name" value="Emp24-like"/>
    </dbReference>
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        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
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    </evidence>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
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            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
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            <dbReference type="EMBL" id="PCH41231.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="204" mass="23288" checksum="4B37911E777A7734" modified="2018-01-31" version="1">MSRHYTPSFFMLCLSLLAVIPTLVSAHMIEVPAGNKECFFEDLHVNDKMTVTYQVGGGGHLDIDFWLQDPDHNALANHQKQSTGTVSITAKKDGRYEYCFSNLMSTVVDKLLSFNVHGVIYVDDDAADTVAPIEREIRNLANGLTAVKDEQEYIVLRERRHRDTAESTNSRVKWWSIFQAAVLFSVVAWQVYYLKSFFEVKRAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JHB1</accession>
    <name>A0A2H3JHB1_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_151625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH41580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JHB1"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH41580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="175" mass="19168" checksum="652D78EECF76CC7D" modified="2018-01-31" version="1">MPCLRFTVQKTDESGVANEYAHHLTVTRRDARREQPSSPAIGAARRGVDGTYAPSWVLGAFPRSPTLGNLAKQASQIVIPRAQHRAQGSLRREKRPGRFITAAKCKASATYTDGPSSYGKRRSHAQNRARPRRESVCPHTPRSPPALPAPSATYHVDAVDDVKRRLPLYHDGGGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JHE0</accession>
    <name>A0A2H3JHE0_WOLCO</name>
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        <recommendedName>
            <fullName evidence="10">Transcription factor IIIC subunit 5 HTH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WOLCODRAFT_17227</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH41610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="742152.A0A2H3JHE0"/>
    <dbReference type="OMA" id="PPEYFVR"/>
    <dbReference type="OrthoDB" id="5598268at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001002">
        <property type="term" value="F:RNA polymerase III type 1 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001003">
        <property type="term" value="F:RNA polymerase III type 2 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.160">
        <property type="entry name" value="TFIIIC, subcomplex tauA, subunit Sfc1, barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019136">
        <property type="entry name" value="TF_IIIC_su-5_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040454">
        <property type="entry name" value="TF_IIIC_Tfc1/Sfc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041499">
        <property type="entry name" value="Tfc1/Sfc1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042536">
        <property type="entry name" value="TFIIIC_tauA_Sfc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13230:SF5">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13230">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIIC, POLYPEPTIDE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09734">
        <property type="entry name" value="Tau95"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17682">
        <property type="entry name" value="Tau95_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="Transcription factor IIIC subunit Tfc1/Sfc1 triple barrel" evidence="7">
        <location>
            <begin position="31"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription factor IIIC subunit 5 HTH" evidence="6">
        <location>
            <begin position="209"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF09734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PCH41610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="540" mass="61419" checksum="C3BF00EAA87F579D" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JHR3</accession>
    <name>A0A2H3JHR3_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_52098</name>
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    <organism evidence="2 3">
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        <lineage>
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            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467920">
        <property type="protein sequence ID" value="PCH37268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JHR3"/>
    <dbReference type="STRING" id="742152.A0A2H3JHR3"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH37268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="259" mass="29616" checksum="C9B62AD8BB689A21" modified="2018-01-31" version="1" fragment="single">KVPPPPEFSGAEGKVQAKEWIEKLGLYFSKVKPADDEERITMALYWLSGEAYRFMGPLLEKAGNGELLGTWADFKKQILNQYAKKTDKEIAEKEIKAFYGSSGKKKVETNFFTYCSKFRTLGRLSEIDGTTLLREFKEVLPEKVRDHVAILGRVTPAAIPTDWDKFVDLCLELYKIAYPDKLDGSIFKEDKKEEKKEKKEEKKEQPKETAPKKAHSKGKGKATPAPQKKPTESTEEVCSYCKQKGHSYQSCFKLRKDKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JIE0</accession>
    <name>A0A2H3JIE0_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">WOLCODRAFT_128474</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoplasmic ribonucleoprotein granule</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA2/NAM7 helicase family. SDE3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="3"/>
    <dbReference type="EMBL" id="KB467931">
        <property type="protein sequence ID" value="PCH37498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JIE0"/>
    <dbReference type="STRING" id="742152.A0A2H3JIE0"/>
    <dbReference type="OMA" id="FGWIFID"/>
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</entry>
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    <accession>A0A2H3JIS0</accession>
    <name>A0A2H3JIS0_WOLCO</name>
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            <fullName evidence="11">Nucleoporin Nup54 alpha-helical domain-containing protein</fullName>
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        <name evidence="9" type="ORF">WOLCODRAFT_137683</name>
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        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Basidiomycota</taxon>
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            <taxon>Agaricomycetes</taxon>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="entry name" value="NUCLEOPORIN P58/P45 NUCLEOPORIN-LIKE PROTEIN 1"/>
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    </evidence>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JJJ0</accession>
    <name>A0A2H3JJJ0_WOLCO</name>
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        <recommendedName>
            <fullName evidence="2">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_52695</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
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            <taxon>Phaeolaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467943">
        <property type="protein sequence ID" value="PCH38949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JJJ0"/>
    <dbReference type="OrthoDB" id="2803471at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH38949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="102" mass="11406" checksum="0EC791A0C0C185B4" modified="2018-01-31" version="1" fragment="single">LILYDYSLTLGQEIRLIWTRKSRSKSPIALFMLNRCVMISVAVAYILLIPWINATVTVSIAVSLTYILPVVSALRVYAITQQRWLLTTVAMLLGLAPVAIDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JJL4</accession>
    <name>A0A2H3JJL4_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_108357</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467865">
        <property type="protein sequence ID" value="PCH36187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JJL4"/>
    <dbReference type="STRING" id="742152.A0A2H3JJL4"/>
    <dbReference type="OMA" id="WGMASAF"/>
    <dbReference type="OrthoDB" id="4177236at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF39">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="23"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH36187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="216" mass="25023" checksum="6DF7AF8422ED6DE4" modified="2018-01-31" version="1">MKCEDVNDSEPLAISLVRESTTIPVPAVRRYLTVNGNNAIIMDYIPGQTLEDCWGQLGFWRRLRVVWTIRRYIRQLQRVLVPGTPRSKQFPGRIGNGPQLSPSAEDHVHTATLGASAQFLTDVEYFTFDSSLPLVLTHLDLNPRNLMIDHDSCVWFIDREHASFYPQWFEYVAMLNGWEMLGRWRGWILGFMAGFYRRQNSFIAKISWAIETGHFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JKR3</accession>
    <name>A0A2H3JKR3_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WOLCODRAFT_74128</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD-104</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468135">
        <property type="protein sequence ID" value="PCH42796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JKR3"/>
    <dbReference type="STRING" id="742152.A0A2H3JKR3"/>
    <dbReference type="OMA" id="WEGRRIS"/>
    <dbReference type="OrthoDB" id="6692864at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11061">
        <property type="entry name" value="CYP67-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF187">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="350"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PCH42796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="407" mass="45694" checksum="5E9178A4C440985B" modified="2018-01-31" version="1">MSVWEGRRISGKRGAGAKNAKGHLIGARNKELHAESRRTWNRAFTTAAVKDYEPIMVRRAAQLVEELRMRCAEQQRNEVQVDLSRWLSYFTFDFMGDMVFGGGFELMHEGDRDGMYQTMVSGLYLPALSQQIPWCARALPYLPFVGKHMKALGQFAFKQVTRRLQEGSVQNDLFYHLLDEKPEDGKPTPFPVIMTNAVTAMLAGSDTTAVALCNAAYYLLSNPACLAHLREEVDATFPPDKGEPVDAAKLASMEYLNACINEALRLLPSIPTSLQRAPTPGSSSHQISPQLVIGEGTAVFVPPYVIQRDPRYFSPDPDRFWPERWLADRDPSVVLNTNAYIPFSTGPANCVGRPVALLALRIVLAYLVQRFEMRLADGYDPKRWGDELRDFFAFQKGALPVVLTPRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JLE1</accession>
    <name>A0A2H3JLE1_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UPF0261 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_144334</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="742152.A0A2H3JLE1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Tm-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12030">
        <property type="entry name" value="Uncharacterised protein family UPF0261, NC domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12020">
        <property type="entry name" value="Uncharacterised protein family UPF0261, NN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051353">
        <property type="entry name" value="Tobamovirus_resist_UPF0261"/>
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        <property type="entry name" value="UPF0261"/>
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        <property type="entry name" value="UPF0261_C"/>
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        <property type="entry name" value="UPF0261_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002674">
        <property type="entry name" value="PRK02399.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31862">
        <property type="entry name" value="UPF0261 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G10120)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31862:SF1">
        <property type="entry name" value="UPF0261 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G10120)"/>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <end position="182"/>
        </location>
    </feature>
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        <location>
            <begin position="206"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH43026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="454" mass="48112" checksum="8E41C8BB7ED5299D" modified="2018-01-31" version="1">MSTAPPTVALIGTCDTKLDELLYVHDKLVNEYGVQCKLIDVGRTPSQHPSIAITQLDIFVSSGIDPPSDLQSLPRGKLISTIIKHTIPLVKSLRESGAIHAALSMGGSGGTSLGSEVMRAALPLGFPKLIVSTMAAGDAHPFVGESDLAMMHSVVDIAGLNDILCPILDNAAGAIAGMARAQRARLLEGPPPSPTSGISPASPGNKRIAITMFGVTTPAVTHARKLLAAYPCTTYVFHASGAGGRAMEKLAVAGFWSGILDLTTTELADALLGGVLSAGDARLTAAAHARIPQVVSLGALDMCNFGPRDTVPGQYRGRNLFEHNPSTTLMRTTAEECRVLGRQIAERLRYADQDNTAVWIPKKGVSALSVKDAPFWDPDADAALFAAVKEGLNSTQIRVIEEEREVNDPLFVEGMTVVLVTKSCGKRLAPSAHEVWRELVLESIFITRRTSAQS</sequence>
</entry>
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    <accession>A0A2H3JLK5</accession>
    <name>A0A2H3JLK5_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Casein kinase substrate phosphoprotein PP28 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_153142</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468135">
        <property type="protein sequence ID" value="PCH43080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OMA" id="IDMESPR"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019380">
        <property type="entry name" value="Casein_kinase_sb_PP28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039876">
        <property type="entry name" value="HAP28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22055">
        <property type="entry name" value="28 KDA HEAT- AND ACID-STABLE PHOSPHOPROTEIN PDGF-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10252">
        <property type="entry name" value="PP28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Casein kinase substrate phosphoprotein PP28" evidence="2">
        <location>
            <begin position="115"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH43080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="209" mass="23480" checksum="7B6AFD1FA11A0CEE" modified="2018-01-31" version="1">MARGGFKLKRGGGRNFSKHLTLDENGTAVATDRWGKREKRDSDAEESEEEEEESEEEEEEEEEASAAGAGTQQPELSRVERRELAKKKKAQAQGKQQQAEEEDEEDEDQDPLLQNPNAAVGKALAISDLGAPRELTRREREEKEKKEAKERYWKLHEQGKTEQAKTDLARLAKIRAEREAAQAKRKAETEAKAAELAAKKEAAARGKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JLU9</accession>
    <name>A0A2H3JLU9_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_137031</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
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                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
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                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH40833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="742152.A0A2H3JLU9"/>
    <dbReference type="OMA" id="YVGCTFI"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053209">
        <property type="entry name" value="Gramillin-biosynth_MTr"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
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    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="TPR DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G12710)"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR47643:SF2">
        <property type="entry name" value="TPR DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G12710)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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            <end position="532"/>
        </location>
    </feature>
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        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH40833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="757" mass="84977" checksum="DAC9DB411F73AD76" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JM21</accession>
    <name>A0A2H3JM21_WOLCO</name>
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        <recommendedName>
            <fullName evidence="2">DUF6533 domain-containing protein</fullName>
        </recommendedName>
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        <name evidence="3" type="ORF">WOLCODRAFT_28900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467909">
        <property type="protein sequence ID" value="PCH37047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JM21"/>
    <dbReference type="STRING" id="742152.A0A2H3JM21"/>
    <dbReference type="OMA" id="MSIHAIV"/>
    <dbReference type="OrthoDB" id="2638860at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="2">
        <location>
            <begin position="26"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH37047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="333" mass="37052" checksum="3730827B23E08A10" modified="2018-01-31" version="1">MSALDVYVSDPLEILVVHGAAVNAMTLAGFSALLFDHILTVSDKINYVWNARKGIVSIIFLMNRYIVPLVLAVDIYETLGLVDSPSSVLFCKVWTTVQSYLTIASFMSIHAIVAWRLYALHGGETWIRWTLWISSILYVSSSTAIITAALVPIILNLRPYHHQCVSSIPSYLWTAWLPSILFETLLFSLTIVAMLRQEKRRSFSTLSLLLYRDGMLYFVAVTVCSLFSLLVWALAGPSLIGLARYFALAMVNIAGSRLVLNLKGFSASQRSASLPTFSLYSSNAALTRQPPPVSPAKAESTMSDFEYPGEDLDFEMYSIERDSQQLGTKLLHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JM95</accession>
    <name>A0A2H3JM95_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_95791</name>
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    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
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        <lineage>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH37764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JM95"/>
    <dbReference type="STRING" id="742152.A0A2H3JM95"/>
    <dbReference type="OMA" id="RATHQCA"/>
    <dbReference type="OrthoDB" id="2791079at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF261">
        <property type="entry name" value="ZINC FINGER CONTAINING PROTEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="93"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH37764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="452" mass="50653" checksum="2D4CF902E44F0A9E" modified="2018-01-31" version="1">MQSAESLIVQDFFEPGIGETLHAVRQLLSSTEHVETAMRLESASAMPLIELLDQVPVDLDDHLFLSAFHTLKKLCALHLYLPRSFMFTDDLRKMSDQAETSGAFADIWHGCYNGLNVAVKSIRIFNSIMVITYDPQGFCTEAVIWRHLSHPNVTPFLGINTTQFRLSMVCKWMPKGNIRSYIHAHPSADRPMLVMDVARGLEYLHSMGVVHGDMKGANILVNGEGRACLSDFGLAAVIYDDSTVNVATTASFATGTIRWMAPEILDPERAGIDVALALPESDVYSYAMVVWEIFTGRSPFDKQRLDAAVMYQILSGVRPEYTPEAIVLGLSEDMWQLIELCWHPDRSQRPNMYEVVSKLRTILRIPSTPASKHPRRRRELQNLHVAGAGQVSRTFVERAERDKVLRNSAAIITLLLCSSCLCTRATHQCAEYDVAASIKSFSEISKPLFLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JMJ0</accession>
    <name>A0A2H3JMJ0_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 16">mRNA-capping enzyme subunit alpha</fullName>
            <ecNumber evidence="3 16">2.7.7.50</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 16">GTP--RNA guanylyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13 16">mRNA guanylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">WOLCODRAFT_87665</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
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        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Second step of mRNA capping. Transfer of the GMP moiety of GTP to the 5'-end of RNA via an enzyme-GMP covalent reaction intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 5'-end diphospho-ribonucleoside in mRNA + GTP + H(+) = a 5'-end (5'-triphosphoguanosine)-ribonucleoside in mRNA + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:67012"/>
            <dbReference type="Rhea" id="RHEA-COMP:17165"/>
            <dbReference type="Rhea" id="RHEA-COMP:17166"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:167616"/>
            <dbReference type="ChEBI" id="CHEBI:167617"/>
            <dbReference type="EC" id="2.7.7.50"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:67013"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Heterodimer. The mRNA-capping enzyme is composed of two separate chains alpha and beta, respectively a mRNA guanylyltransferase and an mRNA 5'-triphosphate monophosphatase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the eukaryotic GTase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.50" evidence="3 16"/>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH37854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="742152.A0A2H3JMJ0"/>
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    <dbReference type="OrthoDB" id="200924at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031533">
        <property type="term" value="C:mRNA capping enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004484">
        <property type="term" value="F:mRNA guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006370">
        <property type="term" value="P:7-methylguanosine mRNA capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Adenylation_mRNA_capping"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="mRNA-capping enzyme subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
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        <property type="entry name" value="mRNA_cap_enzyme_adenylation"/>
    </dbReference>
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        <property type="entry name" value="mRNA_cap_enzyme_alpha"/>
    </dbReference>
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        <property type="entry name" value="mRNA_cap_enzyme_C"/>
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        <property type="entry name" value="mRNA_Capping_Enz/RNA_Phosphat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10367">
        <property type="entry name" value="MRNA-CAPPING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10367:SF17">
        <property type="entry name" value="MRNA-CAPPING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03919">
        <property type="entry name" value="mRNA_cap_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01331">
        <property type="entry name" value="mRNA_cap_enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036959">
        <property type="entry name" value="mRNA_cap_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 16" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9 16" id="KW-0506">mRNA capping</keyword>
    <keyword evidence="5 16" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 16" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP-dependent DNA ligase family profile" evidence="19">
        <location>
            <begin position="135"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="371"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="18">
        <location>
            <begin position="378"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="active site" description="N6-GMP-lysine intermediate" evidence="17">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR036959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR036959-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="PCH37854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="418" mass="48021" checksum="E0E1691C85167C15" modified="2018-01-31" version="1">MSRIPELPGSPVPARSEQEQWLRQNVARLCQLENERFPGSQPVSFGMQDLDKLEGKDYWVCEKSDGVRVLLLVLTNIHTMDQMVYLIDRHNSYRELSGLYFPHHEDPTKPLRSTLVDGELVVDVDPRTQHETLRYLAFDCLVVDDQNVMSKPLDKRYGRLKLWFHQPYAKMMREFPHMAQTQPFEIKVKEVKFSYHVGDVFNIDLPALQHGNDGLIYTCAETPYIPGTDQNILKWKPPSENSIDFKLVLRFPPHTAGKGPPQPDLYARPVFELHVYCGDERGAARYEFYDVMHVADDEWESLKASGEQVDERIVEVHWDLVHERWRMMRFRDDKPAGNFKTVVDNIIQTIHDGVEKEQLIERSAAIRNAWKARHGQPGKPPPPAKPPPPADAAPRYGPLAASRWSKVTGPTVVAGMSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JN18</accession>
    <name>A0A2H3JN18_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_138442</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468146">
        <property type="protein sequence ID" value="PCH43572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="742152.A0A2H3JN18"/>
    <dbReference type="OMA" id="HFPPAEQ"/>
    <dbReference type="OrthoDB" id="3219024at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="132"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="341"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH43572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="482" mass="51179" checksum="850537B310CA10A1" modified="2018-01-31" version="1">MPARAHRGALPRTHTRTNSGGSSKLGLNNLQFTQKDAPPPRTTDKSRKSPHAHHEPAARAVAPLSRNGSSHRIASREHIQPAPLRRAPTPLGPGKPQSGRQRADFTISGPSEGDDDEWVSSESGAATPNSATDSDGGDTTTPLDRTKSTLARTTTQLNGYHTEDVATPRADAPLLPRVDVVRASEPPSPAPTARDYIQAQPTPQMVDGSQHAPAHDQRSPPQAERPPEAEVQPPPQAAQPPETQPPPITRARSETRSPTRTSPPPKRQSMTRPPSTHSVTSKSEGAALRPHPLIRGHSYGHHNGTFAAMPAPLAPLTMVSSDAAQAEMSTASSPTSVRAGSPSSIKTASASPSQSSPTSSQAHRQLRRTSTSSARSTSTLPVSVSQSQLSKSSHDRQRTLSTISSSSSFAALSSLAMRATPSPPRTPVTYTAHFPPAEQSASLELIHPLLPPPYLSSHITVLAYRNPIAESYDRVICAKQAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JN46</accession>
    <name>A0A2H3JN46_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_140849</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
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                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2 pyruvate + H(+) = (2S)-2-acetolactate + CO2</text>
            <dbReference type="Rhea" id="RHEA:25249"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="2.2.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="12">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="12">Binds 1 thiamine pyrophosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.6" evidence="12"/>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH37937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JPJ3"/>
    <dbReference type="STRING" id="742152.A0A2H3JPJ3"/>
    <dbReference type="OMA" id="QETDMIG"/>
    <dbReference type="OrthoDB" id="16262at2759"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00055"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005948">
        <property type="term" value="C:acetolactate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
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        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
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        <property type="entry name" value="TPP_AHAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07035">
        <property type="entry name" value="TPP_PYR_POX_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1220:FF:000008">
        <property type="entry name" value="Acetolactate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000007">
        <property type="entry name" value="Acetolactate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012846">
        <property type="entry name" value="Acetolactate_synth_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039368">
        <property type="entry name" value="AHAS_TPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00118">
        <property type="entry name" value="acolac_lg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968:SF13">
        <property type="entry name" value="ACETOLACTATE SYNTHASE CATALYTIC SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="THIAMINE PYROPHOSPHATE ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11 12" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="8 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="6 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="16">
        <location>
            <begin position="99"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="14">
        <location>
            <begin position="299"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="15">
        <location>
            <begin position="507"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="46"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="78"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PCH37937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="695" mass="75034" checksum="6F45CE42B7D163AB" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JQ61</accession>
    <name>A0A2H3JQ61_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_37174</name>
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    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
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        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH44300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="67" mass="7895" checksum="3B2CBDC3B11031DB" modified="2018-01-31" version="1" fragment="single">LPVWVYALVWSQCVLTYLLVKSYLQRRQQKQEMRELGAVEAPVYKGKWPGNLDFILKMLNQAHEGYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JQF0</accession>
    <name>A0A2H3JQF0_WOLCO</name>
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        <submittedName>
            <fullName evidence="5">60S ribosomal protein L17/L23</fullName>
        </submittedName>
    </protein>
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        <name evidence="5" type="ORF">WOLCODRAFT_29239</name>
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    <organism evidence="5 6">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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            <taxon>Agaricomycetes</taxon>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL14 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467943">
        <property type="protein sequence ID" value="PCH38884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JQF0"/>
    <dbReference type="STRING" id="742152.A0A2H3JQF0"/>
    <dbReference type="OMA" id="IRQSKPW"/>
    <dbReference type="OrthoDB" id="407959at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00337">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.150.20:FF:000003">
        <property type="entry name" value="60S ribosomal protein L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.150.20">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01367">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000218">
        <property type="entry name" value="Ribosomal_uL14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036853">
        <property type="entry name" value="Ribosomal_uL14_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761">
        <property type="entry name" value="50S/60S RIBOSOMAL PROTEIN L14/L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761:SF8">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00238">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01374">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50193">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PCH38884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="139" mass="14708" checksum="12FF22BA12EDBCB0" modified="2018-01-31" version="1">MSKRGAGASGNKFRLTLGLPTGAVLNCADNSGAKSLFVIEAYGTGSHLNRLPDAGVGDMVVASVKKGKPELRKKTMPVVVVRQRKSWRRKEGLILYFEDNAGVIVNPKGEMKGSAITGPVAKECADLWPRIASNAGTVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JQH4</accession>
    <name>A0A2H3JQH4_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_158435</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467943">
        <property type="protein sequence ID" value="PCH38904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JQH4"/>
    <dbReference type="OMA" id="IGHEHIK"/>
    <dbReference type="OrthoDB" id="2789562at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH38904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="137" mass="14999" checksum="DB45935DDE56E1E1" modified="2018-01-31" version="1">MSNESDDQIPRLRPELYPFTAARTSGDDPSSQALLASILAAGGSIDEISNIEDFEGVERYLTGSGRASADGRIKFGLVFWLYPTGMYGPYHITEEGEVKRHGTLMTVEPGARISTVMERARAALRTEGIGHEHIKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JQK5</accession>
    <name>A0A2H3JQK5_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription initiation factor TFIID subunit 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WOLCODRAFT_138830</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Functions as a component of both the DNA-binding general transcription initiation factor complex TFIID and the transcription coactivator SAGA complex. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription. SAGA acts as a general cofactor required for essentially all RNA polymerase II transcription. At the promoters, SAGA is required for transcription pre-initiation complex (PIC) recruitment. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction (via core/TAF module) and promoter selectivity, interaction with transcription activators (via Tra1/SPT module), and chromatin modification through histone acetylation (via HAT module) and deubiquitination (via DUB module). SAGA preferentially acetylates histones H3 (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac) and H2B and deubiquitinates histone H2B. SAGA interacts with DNA via upstream activating sequences (UASs).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the TAF10 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468157">
        <property type="protein sequence ID" value="PCH44211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JQK5"/>
    <dbReference type="STRING" id="742152.A0A2H3JQK5"/>
    <dbReference type="OMA" id="GFECDDV"/>
    <dbReference type="OrthoDB" id="154356at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990841">
        <property type="term" value="F:promoter-specific chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07982">
        <property type="entry name" value="HFD_TAF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003923">
        <property type="entry name" value="TAF10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21242">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21242:SF0">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03540">
        <property type="entry name" value="TAF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017246">
        <property type="entry name" value="TFIID_TAF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01443">
        <property type="entry name" value="TFIID30KDSUB"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR017246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PCH44211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="168" mass="18477" checksum="4F34555E9A631CC1" modified="2018-01-31" version="1">MSTPYPEASQNTGYYPPAPPRPAQQQPAPESSQAASTSAQGQQPSRQVAEEARKDRTLAEFLLMLDDYAPLIPDEVTDYYLQRVGFECEDARLKRLLALAAQKFVSDIAADAYQHARIRANAAGGRARTTQTGPASARDKTKTTLMMEDLSAALAEYGITSRKPEFYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JRN5</accession>
    <name>A0A2H3JRN5_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">IgA peptidase M64</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_150474</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468053">
        <property type="protein sequence ID" value="PCH40428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OMA" id="MPIQAYP"/>
    <dbReference type="OrthoDB" id="2961863at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019026">
        <property type="entry name" value="Peptidase_M64_IgA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09471">
        <property type="entry name" value="Peptidase_M64"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH40428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="577" mass="63655" checksum="1B2F34304BCB43D5" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JRY6</accession>
    <name>A0A2H3JRY6_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WOLCODRAFT_137462</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD-104</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH41549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JRY6"/>
    <dbReference type="STRING" id="742152.A0A2H3JRY6"/>
    <dbReference type="OMA" id="WMIVCTS"/>
    <dbReference type="OrthoDB" id="2588832at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00567">
        <property type="entry name" value="ACAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050741">
        <property type="entry name" value="Acyl-CoA_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083:SF28">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ACYL_COA_DH_1"/>
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    </dbReference>
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        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="6">
        <location>
            <begin position="6"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PCH41549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="517" mass="57480" checksum="794454D9AED17725" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JS82</accession>
    <name>A0A2H3JS82_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">sn-1-specific diacylglycerol lipase</fullName>
            <ecNumber evidence="14">3.1.1.116</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">WOLCODRAFT_119388</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 1,2-diacyl-sn-glycerol + H2O = a 2-acylglycerol + a fatty acid + H(+)</text>
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            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
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                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
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                <person name="Murat C."/>
                <person name="Nagy L.G."/>
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            <dbReference type="EMBL" id="PCH39934.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
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        <source>
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</entry>
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        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JWW8"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH42348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="261" mass="29566" checksum="9231887658DD4029" modified="2018-01-31" version="1">MLPHLRSEDCSSFLQELTLVSKLVLSKFDFYSGERFVTLLSSFPNLRHLRFHDTNIWAESDLGEPSNLWRLQHYAKAISLDSLEISLCDVEGRGLIDLLLNLMPRSLPVKRINIFYAFLDLSRNSGLQSIAVIHSELFQEGVPMSLNGWIPEMLSTIRSPTVTSVTFTLTDVGFCTDDVHDDDNTFSGGLSQVLDRMGCGRVDVLVKWTACRWYRDDNLELRYISSAAEGQSTPECDSEELTGRITHAIRSKIPELYRKGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JWX4</accession>
    <name>A0A2H3JWX4_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ER membrane protein complex subunit 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_151267</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH41224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JWX4"/>
    <dbReference type="STRING" id="742152.A0A2H3JWX4"/>
    <dbReference type="OMA" id="YWMYIAI"/>
    <dbReference type="OrthoDB" id="1894652at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22209">
        <property type="entry name" value="EMC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH41224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="338" mass="35700" checksum="3B2B9D901C7CFB29" modified="2018-01-31" version="1">MREHRANLLPPDAEHRAQSQPRMHPASATALVRRRAATRHVSPRSGALPSRRSPASSSNRSRAPGISARPSFARATPLLCTIMLLLPLLAALPLALAADPLRVFHRVWHPALPSQPFLLRGTLDLAAPSLAPAPGLDAGLADFWQAVRALEADADAAVYQVALEHPGAADPALWAISSVRAVRPRCSCARAWGGPGRPPPIHAPHCHLPQATEAEIRVHLAPDRAAYALDYFVAPVPHGGDCPRRGRARGQAAGADTDVARHAANTSVTLIAPSFPPLPLLRTPPPLAADGKPVEAAPEKTFLQKYWIYFAIALVAILISPAGEEEGAGSGGASAGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JY90</accession>
    <name>A0A2H3JY90_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">STEEP1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_137206</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STEEP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH41127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JY90"/>
    <dbReference type="STRING" id="742152.A0A2H3JY90"/>
    <dbReference type="OMA" id="YEMNEHR"/>
    <dbReference type="OrthoDB" id="418131at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090158">
        <property type="term" value="P:endoplasmic reticulum membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR057965">
        <property type="entry name" value="STEEP1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46355:SF1">
        <property type="entry name" value="STING ER EXIT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46355">
        <property type="entry name" value="UPF0428 PROTEIN CXORF56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25809">
        <property type="entry name" value="STEEP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STEEP1" evidence="2">
        <location>
            <begin position="22"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH41127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="145" mass="16180" checksum="049688DFC0BC8BA4" modified="2018-01-31" version="1">MPKVVSRSAVSSSTDARPTASSVAALRVYYCICGEFILVIDKSLTSLPRRKTDDAVVIRCQDSELGKARVFKLNATEQEPLLVERPNGHERQYRFHCPRCNLPVAYQTTPPPVKSAPFLYIFKGALSQIQGQVPPDAFEDEQLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JYK0</accession>
    <name>A0A2H3JYK0_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phenylalanine--tRNA ligase beta subunit</fullName>
            <ecNumber evidence="5">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Phenylalanyl-tRNA synthetase beta subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">WOLCODRAFT_137258</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>tRNA(Phe) + L-phenylalanine + ATP = L-phenylalanyl-tRNA(Phe) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="5"/>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH41227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JYK0"/>
    <dbReference type="STRING" id="742152.A0A2H3JYK0"/>
    <dbReference type="OMA" id="FPGRCAN"/>
    <dbReference type="OrthoDB" id="1698572at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009328">
        <property type="term" value="C:phenylalanine-tRNA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00769">
        <property type="entry name" value="PheRS_beta_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.40.10:FF:000002">
        <property type="entry name" value="phenylalanine--tRNA ligase beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.56.10:FF:000006">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.56.10:FF:000004">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.40.10">
        <property type="entry name" value="Phenylalanyl-trna Synthetase, Chain B, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005146">
        <property type="entry name" value="B3/B4_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045060">
        <property type="entry name" value="Phe-tRNA-ligase_IIc_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004531">
        <property type="entry name" value="Phe-tRNA-synth_IIc_bsu_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020825">
        <property type="entry name" value="Phe-tRNA_synthase-like_B3/B4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041616">
        <property type="entry name" value="PheRS_beta_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040659">
        <property type="entry name" value="PhetRS_B1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005147">
        <property type="entry name" value="tRNA_synthase_B5-dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00471">
        <property type="entry name" value="pheT_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947:SF0">
        <property type="entry name" value="PHENYLALANINE--TRNA LIGASE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE BETA CHAIN AND LEUCINE-RICH REPEAT-CONTAINING PROTEIN 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03483">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03484">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18262">
        <property type="entry name" value="PhetRS_B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17759">
        <property type="entry name" value="tRNA_synthFbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00873">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00874">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56037">
        <property type="entry name" value="PheT/TilS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="Putative DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51483">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 18" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0436">Ligase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B5" evidence="17">
        <location>
            <begin position="300"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00033189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PCH41227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="628" mass="71253" checksum="457FA75DB963D3EC" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JZ63</accession>
    <name>A0A2H3JZ63_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Pentafunctional AROM polypeptide</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="21">3-dehydroquinate synthase</fullName>
                <shortName evidence="21">DHQS</shortName>
                <ecNumber evidence="21">4.2.3.4</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="21">3-phosphoshikimate 1-carboxyvinyltransferase</fullName>
                <ecNumber evidence="21">2.5.1.19</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="21">5-enolpyruvylshikimate-3-phosphate synthase</fullName>
                <shortName evidence="21">EPSP synthase</shortName>
                <shortName evidence="21">EPSPS</shortName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="21">Shikimate kinase</fullName>
                <shortName evidence="21">SK</shortName>
                <ecNumber evidence="21">2.7.1.71</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="21">3-dehydroquinate dehydratase</fullName>
                <shortName evidence="21">3-dehydroquinase</shortName>
                <ecNumber evidence="21">4.2.1.10</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="21">Shikimate dehydrogenase</fullName>
                <ecNumber evidence="21">1.1.1.25</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="28" type="ORF">WOLCODRAFT_119840</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="28 29" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28 29">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="20 21 22">The AROM polypeptide catalyzes 5 consecutive enzymatic reactions in prechorismate polyaromatic amino acid biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21 22">
            <text>3-dehydroquinate = 3-dehydroshikimate + H2O</text>
            <dbReference type="Rhea" id="RHEA:21096"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="EC" id="4.2.1.10"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>3-phosphoshikimate + phosphoenolpyruvate = 5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21256"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="EC" id="2.5.1.19"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:21257"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21 22">
            <text>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate = 3-dehydroquinate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21968"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="EC" id="4.2.3.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19 21 22">
            <text>shikimate + ATP = 3-phosphoshikimate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13121"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.71"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21 22">
            <text>shikimate + NADP(+) = 3-dehydroshikimate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17737"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="21 22">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="21 22">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="21 22">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="21 22">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="21 22">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 21 22">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 5/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 21 22">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="21 22">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 21 22">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the EPSP synthase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="21 22">In the 2nd section; belongs to the EPSP synthase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="21 22">In the 3rd section; belongs to the shikimate kinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="21 22">In the 4th section; belongs to the type-I 3-dehydroquinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="21 22">In the C-terminal section; belongs to the shikimate dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="22">In the N-terminal section; belongs to the dehydroquinate synthase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="21">In the N-terminal section; belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.4" evidence="21"/>
    <dbReference type="EC" id="2.5.1.19" evidence="21"/>
    <dbReference type="EC" id="2.7.1.71" evidence="21"/>
    <dbReference type="EC" id="4.2.1.10" evidence="21"/>
    <dbReference type="EC" id="1.1.1.25" evidence="21"/>
    <dbReference type="EMBL" id="KB468124">
        <property type="protein sequence ID" value="PCH42024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="742152.A0A2H3JZ63"/>
    <dbReference type="OMA" id="SWANMSW"/>
    <dbReference type="OrthoDB" id="197068at2759"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003855">
        <property type="term" value="F:3-dehydroquinate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003856">
        <property type="term" value="F:3-dehydroquinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003866">
        <property type="term" value="F:3-phosphoshikimate 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004764">
        <property type="term" value="F:shikimate 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004765">
        <property type="term" value="F:shikimate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00502">
        <property type="entry name" value="DHQase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08195">
        <property type="entry name" value="DHQS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01556">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01065">
        <property type="entry name" value="NAD_bind_Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00464">
        <property type="entry name" value="SK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1090.10:FF:000007">
        <property type="entry name" value="Pentafunctional AROM polypeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000135">
        <property type="entry name" value="Pentafunctional AROM polypeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1970:FF:000007">
        <property type="entry name" value="Pentafunctional AROM polypeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001256">
        <property type="entry name" value="Pentafunctional AROM polypeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.65.10.10:FF:000007">
        <property type="entry name" value="Pentafunctional AROM polypeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.65.10.10:FF:000008">
        <property type="entry name" value="Pentafunctional AROM polypeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1090.10">
        <property type="entry name" value="Dehydroquinate synthase-like - alpha domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.10">
        <property type="entry name" value="Enolpyruvate transferase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00210">
        <property type="entry name" value="EPSP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03143">
        <property type="entry name" value="Pentafunct_AroM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00222">
        <property type="entry name" value="Shikimate_DH_AroE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00109">
        <property type="entry name" value="Shikimate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016037">
        <property type="entry name" value="DHQ_synth_AroB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030960">
        <property type="entry name" value="DHQS/DOIS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056179">
        <property type="entry name" value="DHQS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001381">
        <property type="entry name" value="DHquinase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001986">
        <property type="entry name" value="Enolpyruvate_Tfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036968">
        <property type="entry name" value="Enolpyruvate_Tfrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006264">
        <property type="entry name" value="EPSP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023193">
        <property type="entry name" value="EPSP_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008289">
        <property type="entry name" value="Pentafunct_AroM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041121">
        <property type="entry name" value="SDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031322">
        <property type="entry name" value="Shikimate/glucono_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013708">
        <property type="entry name" value="Shikimate_DH-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010110">
        <property type="entry name" value="Shikimate_DH_AroM-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022893">
        <property type="entry name" value="Shikimate_DH_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000623">
        <property type="entry name" value="Shikimate_kinase/TSH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023000">
        <property type="entry name" value="Shikimate_kinase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01356">
        <property type="entry name" value="aroA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01357">
        <property type="entry name" value="aroB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01093">
        <property type="entry name" value="aroD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01809">
        <property type="entry name" value="Shik-DH-AROM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21090">
        <property type="entry name" value="AROM/DEHYDROQUINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21090:SF5">
        <property type="entry name" value="PENTAFUNCTIONAL AROM POLYPEPTIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01761">
        <property type="entry name" value="DHQ_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24621">
        <property type="entry name" value="DHQS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01487">
        <property type="entry name" value="DHquinase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00275">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18317">
        <property type="entry name" value="SDH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08501">
        <property type="entry name" value="Shikimate_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01202">
        <property type="entry name" value="SKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000514">
        <property type="entry name" value="Pentafunct_AroM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01100">
        <property type="entry name" value="SHIKIMTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56796">
        <property type="entry name" value="Dehydroquinate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="EPT/RTPC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00104">
        <property type="entry name" value="EPSP_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00885">
        <property type="entry name" value="EPSP_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01128">
        <property type="entry name" value="SHIKIMATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 21 22" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="15 21 22" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="12 21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 21 22" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 21 22" id="KW-0418">Kinase</keyword>
    <keyword evidence="16 21 22" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 21 22" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17 21" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="13 21" id="KW-0521">NADP</keyword>
    <keyword evidence="9 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14 21 22" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 21 22" id="KW-0808">Transferase</keyword>
    <keyword evidence="11 21 22" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="3-dehydroquinate synthase N-terminal" evidence="24">
        <location>
            <begin position="73"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="3-dehydroquinate synthase C-terminal" evidence="27">
        <location>
            <begin position="187"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="Enolpyruvate transferase" evidence="23">
        <location>
            <begin position="410"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="domain" description="Shikimate dehydrogenase substrate binding N-terminal" evidence="25">
        <location>
            <begin position="1337"/>
            <end position="1418"/>
        </location>
    </feature>
    <feature type="domain" description="SDH C-terminal" evidence="26">
        <location>
            <begin position="1585"/>
            <end position="1613"/>
        </location>
    </feature>
    <feature type="region of interest" description="3-dehydroquinate synthase" evidence="21">
        <location>
            <begin position="1"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Shikimate dehydrogenase" evidence="21">
        <location>
            <begin position="1332"/>
            <end position="1622"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for 3-dehydroquinate synthase activity" evidence="21">
        <location>
            <position position="260"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for 3-dehydroquinate synthase activity" evidence="21">
        <location>
            <position position="275"/>
        </location>
    </feature>
    <feature type="active site" description="For EPSP synthase activity" evidence="21">
        <location>
            <position position="839"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for 3-dehydroquinate dehydratase activity" evidence="21">
        <location>
            <position position="1221"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; for 3-dehydroquinate dehydratase activity" evidence="21">
        <location>
            <position position="1249"/>
        </location>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <begin position="44"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <begin position="79"/>
            <end position="82"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <begin position="110"/>
            <end position="112"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate</name>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <begin position="135"/>
            <end position="136"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate</name>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate</name>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate</name>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <begin position="175"/>
            <end position="178"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <begin position="190"/>
            <end position="193"/>
        </location>
        <ligand>
            <name>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate</name>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate</name>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <begin position="264"/>
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                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468168">
        <property type="protein sequence ID" value="PCH44969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K1B8"/>
    <dbReference type="STRING" id="742152.A0A2H3K1B8"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH44969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="139" mass="14706" checksum="1FCE4021A2BEE2CD" modified="2018-01-31" version="1">MTGVHRVCGCAPQGVGVRKVVFGVVHAIVARSRLVDVLFTTHSRSGSRPPVCRSLNVLNPGLVHTVNDAASLLPVIFSAVVHTLWALPSRGAHTSVFAAAAPAVRAQPETDQGAYLQPPGEIGMQTHGILRDIEIMIEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K1G2</accession>
    <name>A0A2H3K1G2_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BSD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_133045</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468146">
        <property type="protein sequence ID" value="PCH43958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K1G2"/>
    <dbReference type="STRING" id="742152.A0A2H3K1G2"/>
    <dbReference type="OMA" id="TYYEGAR"/>
    <dbReference type="OrthoDB" id="73788at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3970.10">
        <property type="entry name" value="BSD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005607">
        <property type="entry name" value="BSD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035925">
        <property type="entry name" value="BSD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051494">
        <property type="entry name" value="BSD_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16019:SF5">
        <property type="entry name" value="BSD DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16019">
        <property type="entry name" value="SYNAPSE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03909">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140383">
        <property type="entry name" value="BSD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50858">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BSD" evidence="2">
        <location>
            <begin position="296"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="90"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="242"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="370"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="404"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="448"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="461"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH43958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="482" mass="51047" checksum="0A9C0D1A84C3ADF7" modified="2018-01-31" version="1">MNFVDAYDITGSSTPSAEGQPETSLNEEVAQVVGQLSRFWGGFRKQSQSVLETARKDLGGVVQQAQKELTRLTADTSASTSSTEPKAEGSADASAAEPSTSAPASDAPATQPQAQPTLLSRLQSTLPPHLLTAVQTKLPDALAHARAASLSAPDLATLRSTLAAELARVQESSGELLLRVQGSSEDLLREASDLLKDAVRVVPPEEARTPVVLPAWDGTDVWMVSGPAREEREGKGKEREASVASRRSTDSARAATRAEALLAQLRHDPTVIRADPVSDAYTAWLEQTGEIEPARIEKEIEAHPELVKLRDTLVPDELDATTFWSRYYFRAHQVEQDEARRKALLQGSTETEEEFSWEDDDDEPSSPNRPATSTSTFAASSAPTSTPSAPPLAEPGTATPPAPASAVPAHLAPAAAAAVAEASPRQSSEESFDVVSAQLSRVGSDAGVSAAPSESEVPSEVDVRDASEGGEGKEGDEDSDWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K2W2</accession>
    <name>A0A2H3K2W2_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WOLCODRAFT_139025</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468157">
        <property type="protein sequence ID" value="PCH44468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K2W2"/>
    <dbReference type="STRING" id="742152.A0A2H3K2W2"/>
    <dbReference type="OMA" id="AAEDWWI"/>
    <dbReference type="OrthoDB" id="5428495at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF147">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G01950)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="8">
        <location>
            <begin position="12"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="381"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="388"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PCH44468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="462" mass="51231" checksum="38182376CA989BD8" modified="2018-01-31" version="1">MPAHRTGAFLDVEFLVIGGGIAGLSVAFILAQAGHHVRVIEKRGLGVHAGGLRVPPNLSKILTQWVGREELVRTAVPCVGTPLRHLSNGHDVGFLHWKPDVMRETGGEFLLIHHEDLHRLLYELATSAGVRVDLNTSVTAIQQGTEALPNPSATLSTGETVTADFIIGADGPRSMVRNVVLNREDEAQPDFLTVYTTTIPGSEMRKDPDLSKWLDSDEWPIWMGTHRSVCGHPVRSKQDFAVHIYSHEGDQNPPTGEETWEDVISIDELDISNHGPRVQKLLKLAPFLLRTRLMKRPEGIDDWVDSTGRIVLVGESAHPWQPGGTHGPSIAVEDAVVFGSLFERLSSWEQVPSFLSAYQELREARCAEVKASDIRNAQMVAMPPGPARDARDEDMRKNSADEWDEGTTKQNFEEMAWVFGYDARDAADEWWVNWGRFSESARQGINIKHLSVGLETLTVETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K392</accession>
    <name>A0A2H3K392_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_164073</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468135">
        <property type="protein sequence ID" value="PCH42877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K392"/>
    <dbReference type="OMA" id="EAFWICC"/>
    <dbReference type="OrthoDB" id="8922241at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH42877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="371" mass="40848" checksum="5F3C8057D9F57039" modified="2018-01-31" version="1">MDQQWLEHYWAHYAGGGDSPDLETVCPQVVKTALPCEPDATSYFDCADQFLGCFGRFGDDDSRPDAYDVRWNDVYTAYDLRASPAPTGGDYGMSRLLSPLYGVHDLQAVSAPTRDDHDLSELLSPVHGVHDMQPSTPTYELLAPPDLHTDHSLLFSPERGPCTHHSDSSTAHAEADVLYTSAEIVTASRPSRSSEHDFASFSIAQANPYVRTDASTPNAAPAALPALTSAPLVPDAPPAPPRPTLRVLPSSTPLIHTPARNAQVPISERARRMARKTGKCPVCGASPNNITRHMNTHDPQRAWVCCGIPLEEWRASANPSAEELRRTRTHMYEDRVMVHGCMQEFHRKDSYMRHLPKNGCLGYAAEIRSAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K3E2</accession>
    <name>A0A2H3K3E2_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DRBM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_26020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
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            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468146">
        <property type="protein sequence ID" value="PCH43564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K3E2"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DRBM" evidence="2">
        <location>
            <begin position="4"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH43564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="80" mass="8682" checksum="CB51FEAC9DB491CC" modified="2018-01-31" version="1">MNASARAKVNELVQKHQVQGKFAYEFEGPVGPRHSQEWTARALYDGLEFGKGKGSSKEAAKEAAAQVALGPLARQLNLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K3K3</accession>
    <name>A0A2H3K3K3_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Expansin-like EG45 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_138472</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468146">
        <property type="protein sequence ID" value="PCH43624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K3K3"/>
    <dbReference type="OMA" id="NFDLAWP"/>
    <dbReference type="OrthoDB" id="5823761at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22278">
        <property type="entry name" value="DPBB_GH45_endoglucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007112">
        <property type="entry name" value="Expansin/allergen_DPBB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22514">
        <property type="entry name" value="EXPB1_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50842">
        <property type="entry name" value="EXPANSIN_EG45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Expansin-like EG45" evidence="1">
        <location>
            <begin position="26"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH43624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="231" mass="24341" checksum="EB21A707AF0048D1" modified="2018-01-31" version="1">MASEWIDYPSNGYATMTHYTLPAGFIAACGCTTDSSNYPTAAMSQMAYGSSTSYGPGCGRCFNLTLLNTFTSDPPFYPEEKNSVVVKITDLCPVGGNGWCSATANKPNAGGAYINFDLAWPSSSIPADFFPSNVTLYGYTDFGVWNISYQSVDCYEYWAGGKTPAALGSVADEAGSVCCPANPTGNDTCPSYSDAKGLPPDTTTSASKLSAIPAIRLLRSAILVSLLHILI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K5A8</accession>
    <name>A0A2H3K5A8_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GroES-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WOLCODRAFT_90388</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD-104</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468146">
        <property type="protein sequence ID" value="PCH43607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K5A8"/>
    <dbReference type="STRING" id="742152.A0A2H3K5A8"/>
    <dbReference type="OMA" id="AIMWARA"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="CAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cinnamyl alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
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    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
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    </dbReference>
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        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
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        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047109">
        <property type="entry name" value="CAD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
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        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
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    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42683">
        <property type="entry name" value="ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="6">
        <location>
            <begin position="16"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PCH43607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="356" mass="38800" checksum="EF10F638163B48C3" modified="2018-01-31" version="1">MPSELEFKGYALTDPSKWSDLKLTSFKPKTFQPEDVEIAITHCGVCGSDVHTLTQGWGESKLPLVAGHEIVGKVTRVGDKVSEFKVGDRVGVGAQIGACLKCRACKSDYENYCPDSIETYNGEYPDGVVTQGGYSTGIRAHERFVFPIPEEIESAHAASMLCAGLTVYSPLKTYGAGPGKKVGIVGIGGLGHYAVLWAKAMGAEVYAFTHDPEKTEDIKEMGADHIIDVTKKDFAKPLAHTLDLIVSTVDVFKSDMPLGDYLSMLFVHGTFITVGIPDADNPLPQLHPFNFAGNGCVLGGSHVGSKKECLEMLELARKKNVRPWIETMPMKDAKRALEGLKSNKVRYRYVLVQDIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K792</accession>
    <name>A0A2H3K792_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Brix-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_104894</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468157">
        <property type="protein sequence ID" value="PCH44307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K792"/>
    <dbReference type="STRING" id="742152.A0A2H3K792"/>
    <dbReference type="OMA" id="AWIISNK"/>
    <dbReference type="OrthoDB" id="264354at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042134">
        <property type="term" value="F:rRNA primary transcript binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10480">
        <property type="entry name" value="Probable brix-domain ribosomal biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044281">
        <property type="entry name" value="IMP4/RPF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734:SF3">
        <property type="entry name" value="RIBOSOME PRODUCTION FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="2">
        <location>
            <begin position="136"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH44307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="401" mass="45263" checksum="282F9AF2AA7022F9" modified="2018-01-31" version="1">MPASRFEPSSIKNKIKREEVARKQKREKRQNKLQRRLAQAKAEANDPLAKKKRREQNVPRTLDNTREFDPSILTANPAAASSSSAAQPEASSSSSPQEHGQAHPPDHQPQDESAADLANDPFASYFSGVADPTVPPKVLITTSQKATRVTYNFCDELVNVFPGAESIRRKKGRGFEMGRIAGWAANRGYSHLMVVNEDTKKPNAITIVYLPDGPTAYFKLTSVELSKRIHGHGRPTDHFPELVLNGFVTRLGHTVGRLFQTLFPPMPEFQGRQVVTLHNQRDFLFFRRHRYAFRSTEKVALQEIGPRFTLKLRSLRKGLPAVKNLGEPSKPLEFDTFEEGERGEDMEMADAEATAQGEEGEGEQSEDKAQAKPKEVVPPTEDEYQWIWKPELETTRRTFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K7N9</accession>
    <name>A0A2H3K7N9_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_165597</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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            <begin position="46"/>
            <end position="140"/>
        </location>
    </feature>
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        <location>
            <begin position="51"/>
            <end position="65"/>
        </location>
    </feature>
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        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
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        <location>
            <begin position="130"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH45094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="167" mass="17914" checksum="B4A281816E71416F" modified="2018-01-31" version="1">MASGLKLQVWSTYAALARPMKEGRAQPARSFALGCPAGRFHAKPQRREYSCVTSIQPNATRQHSCTRADRHQPPHPRCQQQRSREMLDAPSSTSASRQAGASALPHRHRDSAAAQAPWRTAPPARSAGTRPAPARSPSGAPLIACALCARPLTRRGAAPDHAFLADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K824</accession>
    <name>A0A2H3K824_WOLCO</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
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                <person name="Larrondo L.F."/>
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                <person name="Ling A."/>
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                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="PCH44607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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            <begin position="31"/>
            <end position="58"/>
        </location>
    </feature>
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        <location>
            <begin position="46"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH44607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="93" mass="10620" checksum="004158CF9018C161" modified="2018-01-31" version="1">MPHAYDVLAKPLRHTVHSCLRNCLSKRTCEHQAPGNARTTRRLARSPHEARSHTSKIDIRRAARHARRAKPVLAPDQPAYIGDEFVVEGDRRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3ITC8</accession>
    <name>A0A2H3ITC8_WOLCO</name>
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        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
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        <name evidence="9" type="ORF">WOLCODRAFT_93164</name>
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        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Phaeolaceae</taxon>
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    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Vesicular transporter family.</text>
    </comment>
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        <property type="protein sequence ID" value="PCH33242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="440553at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050930">
        <property type="entry name" value="MFS_Vesicular_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506:SF23">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="384"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="419"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="21"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PCH33242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="463" mass="50105" checksum="43591793B20B93D4" modified="2018-01-31" version="1">MVQSSPEHSRRPWGLAWRCSVWYITSGIEFCVTTDLLVYSLIVPVLPFQLEHLGYTGVSGLVGWLLFAYSSGIVLFTPPIAYLSEKYNARQIPLLCGQVALVGAQIMLMLAPTYWLMVIARLLQGLSSSVIWVAGLALICDTVPERSVGQQLGLAMSGLSLGFLVGPPVAGALFSRFGFHGPFIFGIVVTMVDLVGRLFIIERKDALRWGARPLSETRLAAPQSTQDGGTERIAVPSPLSLAPERRSPFYIAIGKLVTSSRAIAVCASTLMYGMILASQEPALPLHLQAIWKLNASKVGIVYIAAVVPTLFSSALAGWWIDKRGTALITIAALSFSLPWIVLLTINSSLAFFIVMFALENFGVSATVSALTAELASTTKILEGVGYAHVYGAFNMAYGVGSALGPIIGGQMYDHLDRGWMAICLFGTGLIVASMILTFAYFEDKPMLNRLVARIRRKREESGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IV84</accession>
    <name>A0A2H3IV84_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_147973</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
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                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
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    <name>A0A2H3IXW5_WOLCO</name>
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        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
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    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Agaricomycetes</taxon>
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            <taxon>Phaeolaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="13"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH34840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="533" mass="59976" checksum="03B23CCAE10EE36F" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IXX6</accession>
    <name>A0A2H3IXX6_WOLCO</name>
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        <recommendedName>
            <fullName evidence="3">Condensation domain-containing protein</fullName>
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        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
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            <taxon>Eukaryota</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <source>
            <dbReference type="EMBL" id="PCH34816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="507" mass="56889" checksum="37331265C08E9F39" modified="2018-01-31" version="1">MSQAYAFSSDNGITYTRKVYGLEALACTLTEAQVPAFYDGLCTMQIPQTTSLEQLHLAVRSAWIQLRHLHPALALQTSRDSDGSWVHHYTVPQSPAAVYEWADATILWHEDKMPLPGRFNELSKRFWRTSSGNYGLELHLGPDNEESKWHIAIHGPHIYADARLVMEIFAELATHLQNALRDGDIFDCTTVAWGEEVTRLAPSPAVLAGDFDTVLKLNDAPPAPPAGFVPFFPPVTKKRSAEGTSISHVVAVDADKAARFRTLCKSHGFTVTQVINSLLSLAHVESALFNAHLRRDSEEYSRAVFDLYSAANTYVIPWGIKDQRPSYEGYTSIHSPKGTPICSIDGFTICLSMDNIRATLNFSEEDPRCVRDTKALWERVVPEYVRFIKSTDLSTQGCLKRQQQEHWRSLNYDPAMLQLPGFWMSSIGDLDRAGFLKEFMPSSAADISISEVMHGCNSDIPIILTDYWQFGGRMVFNLHGGISYHTEEDMETLAGIFMEWIDTVLQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IYD2</accession>
    <name>A0A2H3IYD2_WOLCO</name>
    <protein>
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        </alternativeName>
    </protein>
    <gene>
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        <name type="common">Brown rot fungus</name>
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        <lineage>
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            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
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    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
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                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
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                <person name="Cullen D."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">MD-104</strain>
        </source>
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    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467832">
        <property type="protein sequence ID" value="PCH34751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3IYD2"/>
    <dbReference type="STRING" id="742152.A0A2H3IYD2"/>
    <dbReference type="OMA" id="LSASWCA"/>
    <dbReference type="OrthoDB" id="2187at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19526">
        <property type="entry name" value="RecA-like_PEX1_r2"/>
        <property type="match status" value="1"/>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
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                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
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                <person name="Lindquist E."/>
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                <person name="Martin R."/>
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                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
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                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
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            <dbReference type="DOI" id="10.1126/science.1221748"/>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH34515.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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        <source>
            <strain evidence="2 3">MD-104</strain>
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    </feature>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH35120.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
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    </evidence>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7 8">MD-104</strain>
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            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
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    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0005886">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045225">
        <property type="entry name" value="Uracil/uridine/allantoin_perm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618">
        <property type="entry name" value="NCS1 FAMILY PURINE/PYRIMIDINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618:SF0">
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    </dbReference>
    <dbReference type="Pfam" id="PF02133">
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        </location>
    </feature>
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    <feature type="non-terminal residue" evidence="7">
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    </feature>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH35450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="128" mass="14417" checksum="081179E57EFB788C" modified="2018-01-31" version="1" fragment="single">CIISLALQSWKMLMSTNRFLIFLDGYGIFMGPTIAIMIVNYRVMCRGILRIMDTYSSKPGMTYMYFHGFNVNACFTYICGMMLPFVGFMGTFGVSVPANTTKIDGIGWYVSTVTTGVVYLVMCRIFPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Barry K."/>
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                <person name="Ferreira P."/>
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                <person name="Heitman J."/>
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                <person name="Hori C."/>
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                <person name="Jurgens J.A."/>
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                <person name="Nagy L.G."/>
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                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
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    <feature type="compositionally biased region" description="Basic residues" evidence="1">
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            <end position="118"/>
        </location>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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            <dbReference type="EMBL" id="PCH37336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="143" mass="15455" checksum="EF25D47DABB5298F" modified="2018-01-31" version="1">MHRTSNLLWSNSGAARFNNRAPPVGHAKGFTHPGVQSASHQKARRQTHRLGYHRPPKVTGRHRNVSTGTSSSSTADGQGRSGQKASTPTSLRGGTAQANDNRHRSRYRHRDRPCHAYRGRNVQGGPPLKSAGQTPPSTAIGEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
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    <name>A0A2H3J6J4_WOLCO</name>
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        <recommendedName>
            <fullName evidence="3">Thioredoxin-like protein AAED1</fullName>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
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                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
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                <person name="Benoit I."/>
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                <person name="Carlson A."/>
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                <person name="Ferreira P."/>
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                <person name="Kohler A."/>
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                <person name="Kumar T.K.A."/>
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                <person name="Lindquist E."/>
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                <person name="Murat C."/>
                <person name="Nagy L.G."/>
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                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
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                <person name="Sabat G."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
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        <property type="match status" value="1"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF13911">
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    </dbReference>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="PCH34359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="206" mass="22579" checksum="815ABCC9AE4130EE" modified="2018-01-31" version="1">MNNDPEGKSPQLSSDVLEQAAKLQVYDDQGNAVAFGTLYQDQKTIVVFIRHFFCGSCQQYVIQLATVSPHTLAQANTRLVIIGCGDWHLIKNYRETTGYSGALYADHSRALYHLLALTTSLALTLAGQEKRGYLAGRSFVANVVKSIWDGPLKNPQHIGKQGDISQLGGDFILGPGNVCAFASRMQHTEDHVDVPELMREAGVVYP</sequence>
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<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
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    <name>A0A2H3J6P3_WOLCO</name>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Barry K."/>
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                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
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                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
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                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
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                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD-104</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the glycosyltransferase 22 family. PIGZ subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="11"/>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH37886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J6P3"/>
    <dbReference type="STRING" id="742152.A0A2H3J6P3"/>
    <dbReference type="OMA" id="WVRWSAT"/>
    <dbReference type="OrthoDB" id="10066429at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005599">
        <property type="entry name" value="GPI_mannosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760:SF3">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03901">
        <property type="entry name" value="Glyco_transf_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="141"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PCH37886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="332" mass="37126" checksum="4098DA832CC2C9E9" modified="2018-01-31" version="1">MWTRLLYPPIATTVVATLIIVGLDSIYYQNALWPLILTPLNFLRYNMSTANLAQHGLHPRWLHALVNYPMLIGPLLYYVVAAGMQLVRPPRGVFGSEKPEQEQTPEIRGRDTDSILTITCLSVIVSGIGILSVVPHQEPRFLVPLVIPSIVLVARCGFMRQPSKLFWVSWIVMNALMTPLFGVLHQGGVVPSLFKLHSKVQQARLSEPFDPEFSDAAVNVLYWRTYMPPWHLLSVPEQAVQSGEVALTDLAGAPASEVVDKLRRLAPSTRSYLVAPLYSARIIATDHPECFALEERVFPHLDLDHIVETLELGWRDGLSLGIYSVDTFCLQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J7U6</accession>
    <name>A0A2H3J7U6_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Presequence translocated-associated motor subunit PAM17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WOLCODRAFT_130427</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the PAM complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion inner membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the PAM17 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH37695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J7U6"/>
    <dbReference type="STRING" id="742152.A0A2H3J7U6"/>
    <dbReference type="OMA" id="MIFGFDP"/>
    <dbReference type="OrthoDB" id="5970083at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001405">
        <property type="term" value="C:PAM complex, Tim23 associated import motor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013875">
        <property type="entry name" value="Pam17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28021">
        <property type="entry name" value="PRESEQUENCE TRANSLOCATED-ASSOCIATED MOTOR SUBUNIT PAM17, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28021:SF1">
        <property type="entry name" value="PRESEQUENCE TRANSLOCATED-ASSOCIATED MOTOR SUBUNIT PAM17, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08566">
        <property type="entry name" value="Pam17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9 12" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PCH37695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="175" mass="19992" checksum="D450DD3735B9EB73" modified="2018-01-31" version="1">MPGAQAAHRKGPVTQIEQETLPWSEYLAIRKKKRRWETAMTIPMIVLGFGGGVAYFANLDVDPTKPVFNMDPMVVYGFATLGCAGLGYLFGPVAGSSIWRMTHRRTMRLIEARDREFHQHIVKNRVDPTAQSATNPVPDFYGEKIGSLHDYRQWLRDQSKYKKKAFFPEDERSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J7W3</accession>
    <name>A0A2H3J7W3_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-serine/threonine phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Nuclear proteasome inhibitor UBLCP1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">WOLCODRAFT_87560</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 16">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 16">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="3"/>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH37715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J7W3"/>
    <dbReference type="STRING" id="742152.A0A2H3J7W3"/>
    <dbReference type="OMA" id="TVHTPKY"/>
    <dbReference type="OrthoDB" id="1711508at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090364">
        <property type="term" value="P:regulation of proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011943">
        <property type="entry name" value="HAD-SF_hydro_IIID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051658">
        <property type="entry name" value="UBLCP1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02245">
        <property type="entry name" value="HAD_IIID1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48493">
        <property type="entry name" value="UBIQUITIN-LIKE DOMAIN-CONTAINING CTD PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48493:SF1">
        <property type="entry name" value="UBIQUITIN-LIKE DOMAIN-CONTAINING CTD PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="12">
        <location>
            <begin position="24"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="FCP1 homology" evidence="13">
        <location>
            <begin position="150"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PCH37715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="343" mass="39129" checksum="09F9DB66CEC5C4B6" modified="2018-01-31" version="1">MLATKGDSQCPGKQWFHLEFRWGGKDFSVDIEASDRVYDLKGLLQSLTDVPPQRQKILGLIKGGKLPPDEERIGDLKLITEKKFTLIGTPQGHEIKDPSQVDFLPDVINDLDVDFSANPAAAEEYINDLRNQRKVREHTQKLKINIIHPLREGKRLLVLDIDYTILDTKPLTSGALPPSECARPRLHEFLEAVYPFYDICIWSQTSWIWVETKLIELGMLGGGRNYERAVLDKTSMFTVFSKREGKQFKHSVKALQIIWNHLPQFNASNTLHVDDLGRNFALNPGEGVKIPAFKDAGTPRAMADRELDKLARYMIQIATTHDDFRNVNHKDWRTIANSLLPLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J8V3</accession>
    <name>A0A2H3J8V3_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">3-hydroxyisobutyrate dehydrogenase</fullName>
            <shortName evidence="9">HIBADH</shortName>
            <ecNumber evidence="3 9">1.1.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WOLCODRAFT_136392</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 9">
            <text>3-hydroxy-2-methylpropanoate + NAD(+) = 2-methyl-3-oxopropanoate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17681"/>
            <dbReference type="ChEBI" id="CHEBI:11805"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57700"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Amino-acid degradation; L-valine degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HIBADH-related family. 3-hydroxyisobutyrate dehydrogenase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.31" evidence="3 9"/>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH38682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J8V3"/>
    <dbReference type="STRING" id="742152.A0A2H3J8V3"/>
    <dbReference type="OMA" id="MGKKVWH"/>
    <dbReference type="OrthoDB" id="435038at2759"/>
    <dbReference type="UniPathway" id="UPA00362"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008442">
        <property type="term" value="F:3-hydroxyisobutyrate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000006">
        <property type="entry name" value="3-hydroxyisobutyrate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002204">
        <property type="entry name" value="3-OH-isobutyrate_DH-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011548">
        <property type="entry name" value="HIBADH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="HIBADH-like_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01692">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22981:SF7">
        <property type="entry name" value="3-HYDROXYISOBUTYRATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22981">
        <property type="entry name" value="3-HYDROXYISOBUTYRATE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00895">
        <property type="entry name" value="3_HYDROXYISOBUT_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0101">Branched-chain amino acid catabolism</keyword>
    <keyword evidence="6 9" id="KW-0520">NAD</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase NADP-binding" evidence="10">
        <location>
            <begin position="22"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyisobutyrate dehydrogenase-like NAD-binding" evidence="11">
        <location>
            <begin position="205"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000103-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU910714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PCH38682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="343" mass="36057" checksum="9843D3FDBA70C222" modified="2018-01-31" version="1">MKATACLLNVARPLTASRAQSMSFVGLGRMGFEMAYNLFSRTLVENGSGARFVVCDARKETAEGFASNFLHHFPGARIDVALTPEEALLASRTIITMLPSSPHVQSVYSESQGIISALRTLPPDEAQSTLCIDSTTLDVQVARGVAAEVQVTGANMVDAPVSGGVIGAKAATLSFLVGGSDAAFELARPTLAHMGKKIIHCGSSGAGLAAKICNNLMLGVEQIVTAEAMILGQKLGLEPKVLAAVVNSSTGGCWSSLMNNPVPGAVPDKSPPSERDFEGGFATSLMLKDMGLAKDVAEKMESPLPLGCAAEELYATVIKNDPELANKDFSSVYRYMRTAETRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J9V4</accession>
    <name>A0A2H3J9V4_WOLCO</name>
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        <recommendedName>
            <fullName evidence="5">Glycoside hydrolase family 16 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_156216</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467854">
        <property type="protein sequence ID" value="PCH35519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J9V4"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013937713" description="Glycoside hydrolase family 16 protein" evidence="2">
        <location>
            <begin position="25"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH35519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="130" mass="13339" checksum="6E15B211BB17A90B" modified="2018-01-31" version="1">MFSKSSAASLVAVVIVACLVGVQGAAVNFSVHDPWSTIPRISPFSTHSPFSTLAPFTTTAANATATGTGNGTDPTPIKRAFSTHSPFSVNDPWSTIPRISPFSARAPFTTQSANATATPTTNGTVPTTAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
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    <name>A0A2H3JAL0_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_145455</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467832">
        <property type="protein sequence ID" value="PCH34698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JAL0"/>
    <dbReference type="STRING" id="742152.A0A2H3JAL0"/>
    <dbReference type="OrthoDB" id="10039566at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH34698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="457" mass="51851" checksum="E195196F8F344978" modified="2018-01-31" version="1">MSLRTGTYTITNVRFLNRLRLPNSDGEEPVVGKIPLGDDIPPEDQWQISRTPGDHTIRCSIRNVKFGNYLSTRPHTSEGEPIFGASREYCWNLYADAIEDNIYRICTPPNSRDGSTLSLALNDESDYTPIEEFPRIARRPFPFQQDESSVSLRLLQQKPDQETMLVELEWTGLSSGYIIEFMDPISVIFHGEIVGDALVNNGFETSSEIVHASLRARDTNAFRDFAQSVLCAEQVQISFLIGGFRYYPADATRRPSDWEYIYRRSWKKDLSFRGLQSFRNKVSLKGILITGCKNDEAGRPYLLINITAGIQNNTNLSITADYSLDGYYGRHMIGTVKLSNFAVNSNSNNEKEVNGRFQPAIPIHNEVATFRVKVYIEGVNIAYVDHKFEPPLHIPTASGIWSPEINRARVTESWIVAAQLALDRSAMLNLDVTNVEIKIKKFHATDLHFKLQDVPYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JAZ4</accession>
    <name>A0A2H3JAZ4_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_167256</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467898">
        <property type="protein sequence ID" value="PCH36983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JAZ4"/>
    <dbReference type="OrthoDB" id="2340858at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH36983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="354" mass="38578" checksum="033C2D8B24C1D4C8" modified="2018-01-31" version="1">MKKSPRSGKTSTHWWSDDTKPSQYLRLGYQGHIVAIANDQIEAPVEAFERLSSRRFLCEKALVFEDGFYIPHSQSQPSFDAFVYEAGPQRATIFQVTVSNQHPISTEGLDWLYNCGAKSLRLVVVTPPLKGSVLDIWVANSHKDMLGEVYHLALPNLKKCSVAELESIMPTSTAGGRVAAVEPSTQPRGTLPHKSKSKKENKKAALLQPVQSARKKGEASNTALVPAPNPSSAPMPASIPSPMQPKSNDRKGKAVMSSSKSIISAAIPPAQPSQQPSDKDQAPGKARERKRKRNERPTADTEARPASPPYVPAAKKIKTCKEKEREAMGSAALPGRRMARRWRTDGAVMGKLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JBC0</accession>
    <name>A0A2H3JBC0_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tripeptidyl-peptidase II</fullName>
            <ecNumber evidence="4">3.4.14.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">WOLCODRAFT_29622</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Secreted tripeptidyl-peptidase which degrades proteins at acidic pHs and is involved in virulence.</text>
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    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal tripeptide from a polypeptide.</text>
            <dbReference type="EC" id="3.4.14.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="15">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
            <location evidence="3">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.4.14.10" evidence="4"/>
    <dbReference type="EMBL" id="KB468009">
        <property type="protein sequence ID" value="PCH39552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="742152.A0A2H3JBC0"/>
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    <dbReference type="OrthoDB" id="409122at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="F:serine-type endopeptidase activity"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008240">
        <property type="term" value="F:tripeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Peptidases_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Pro-peptidase_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Tripeptidyl peptidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Peptidase S8/S53 domain"/>
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    </dbReference>
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        <property type="entry name" value="Sedolisin_dom"/>
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        <property type="entry name" value="Tripeptidyl-peptidase_I"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TRIPEPTIDYL-PEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00944">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51695">
        <property type="entry name" value="SEDOLISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11 15" id="KW-0106">Calcium</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15 19" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="10 15" id="KW-0720">Serine protease</keyword>
    <keyword evidence="8 17" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0843">Virulence</keyword>
    <keyword evidence="13" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013588112" description="tripeptidyl-peptidase II" evidence="17">
        <location>
            <begin position="17"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S53" evidence="18">
        <location>
            <begin position="214"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="15">
        <location>
            <position position="290"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="15">
        <location>
            <position position="294"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="15">
        <location>
            <position position="487"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="529"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="530"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="548"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="550"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012462"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
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    </evidence>
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    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51695"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH39552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="569" mass="59678" checksum="78E38764EDB05DC0" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JBC2</accession>
    <name>A0A2H3JBC2_WOLCO</name>
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            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">WOLCODRAFT_91811</name>
    </gene>
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        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
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                <person name="Stenlid J."/>
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                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="338"/>
        </location>
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    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH36039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
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            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JBD8</accession>
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        <name evidence="13" type="ORF">WOLCODRAFT_79934</name>
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        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The plasma membrane ATPase of plants and fungi is a hydrogen ion pump. The proton gradient it generates drives the active transport of nutrients by H(+)-symport. The resulting external acidification and/or internal alkinization may mediate growth responses.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 10">
            <text>ATP + H2O + H(+)(in) = ADP + phosphate + 2 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:20852"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.1" evidence="10"/>
    <dbReference type="EMBL" id="KB467843">
        <property type="protein sequence ID" value="PCH34978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JBD8"/>
    <dbReference type="SMR" id="A0A2H3JBD8"/>
    <dbReference type="STRING" id="742152.A0A2H3JBD8"/>
    <dbReference type="OMA" id="FAYQFDF"/>
    <dbReference type="OrthoDB" id="116380at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008553">
        <property type="term" value="F:P-type proton-exporting transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120029">
        <property type="term" value="P:proton export across plasma membrane"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02076">
        <property type="entry name" value="P-type_ATPase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000268">
        <property type="entry name" value="ATPase 4 plasma membrane-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000004">
        <property type="entry name" value="Plasma membrane ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000005">
        <property type="entry name" value="Plasma membrane ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
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        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
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        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006534">
        <property type="entry name" value="P-type_ATPase_IIIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01647">
        <property type="entry name" value="ATPase-IIIA_H"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="299"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="333"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="702"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="730"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="770"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="815"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="848"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="875"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="12">
        <location>
            <begin position="68"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="26"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PCH34978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="999" mass="109358" checksum="30D6C7DC4F8F98FC" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JBH4</accession>
    <name>A0A2H3JBH4_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6699 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_165961</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="entry name" value="DUF6699"/>
    </dbReference>
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        <property type="entry name" value="DUF6699"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6699" evidence="2">
        <location>
            <begin position="209"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="33"/>
        </location>
    </feature>
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        <location>
            <begin position="51"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH35018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="376" mass="40169" checksum="B45439BAAA50C297" modified="2018-01-31" version="1">MANMSSYLRNLFGGSNTSPTSGTAKSSSRTSSSGPVPEVYAPVVNGGDLQRSYSYSVSHTPKPTSTHYSTPARARTQSGHVKRSETSPYATGPPAYSTTQEAGNYPSHAPKVSFITPTSSRSNSNASLHGSVPSIPSSDARHYNVSAHIRPSLQQRQHSHHSSSVTSMSSYGSTSGQPPSYPNPYSHLKVSCLHMHPILAHTRTHNAPLTYDVILPPSAHTVLDCETHSAIPTHTLMQPATDPPMPLGARLVLSSHKLPWPIIVTASNTGPVSPGPRFTIGPPKPDSVITNLDVLYGVHITLLKPVTPEEWAALGVGSRAQQKVARAYQMRCTRMGGGWEAGVRRVDWLGEKTRLVGVEVDKSGGDCGSGKLVFSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JBU4</accession>
    <name>A0A2H3JBU4_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">mRNA-capping enzyme subunit beta</fullName>
            <ecNumber evidence="8">3.6.1.74</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">mRNA 5'-phosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">mRNA 5'-triphosphate monophosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WOLCODRAFT_136466</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">First step of mRNA capping. Converts the 5'-triphosphate end of a nascent mRNA chain into a diphosphate end.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 5'-end triphospho-ribonucleoside in mRNA + H2O = a 5'-end diphospho-ribonucleoside in mRNA + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67004"/>
            <dbReference type="Rhea" id="RHEA-COMP:17164"/>
            <dbReference type="Rhea" id="RHEA-COMP:17165"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:167616"/>
            <dbReference type="ChEBI" id="CHEBI:167618"/>
            <dbReference type="EC" id="3.6.1.74"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:67005"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterodimer. The mRNA-capping enzyme is composed of two separate chains alpha and beta, respectively a mRNA guanylyltransferase and an mRNA 5'-triphosphate monophosphatase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the fungal TPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.74" evidence="8"/>
    <dbReference type="EMBL" id="KB468053">
        <property type="protein sequence ID" value="PCH39732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JBU4"/>
    <dbReference type="STRING" id="742152.A0A2H3JBU4"/>
    <dbReference type="OMA" id="HHMIMTR"/>
    <dbReference type="OrthoDB" id="272147at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031533">
        <property type="term" value="C:mRNA capping enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140818">
        <property type="term" value="F:mRNA 5'-triphosphate monophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004651">
        <property type="term" value="F:polynucleotide 5'-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006370">
        <property type="term" value="P:7-methylguanosine mRNA capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07470">
        <property type="entry name" value="CYTH-like_mRNA_RTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.100.10">
        <property type="entry name" value="mRNA triphosphatase Cet1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040343">
        <property type="entry name" value="Cet1/Ctl1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033469">
        <property type="entry name" value="CYTH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004206">
        <property type="entry name" value="mRNA_triPase_Cet1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037009">
        <property type="entry name" value="mRNA_triPase_Cet1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28118:SF1">
        <property type="entry name" value="POLYNUCLEOTIDE 5'-TRIPHOSPHATASE CTL1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28118">
        <property type="entry name" value="POLYNUCLEOTIDE 5'-TRIPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02940">
        <property type="entry name" value="mRNA_triPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55154">
        <property type="entry name" value="CYTH-like phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0506">mRNA capping</keyword>
    <keyword evidence="4 8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="mRNA triphosphatase Cet1-like" evidence="10">
        <location>
            <begin position="73"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="37"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PCH39732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="331" mass="36357" checksum="305F2D7E63C5FD7F" modified="2018-01-31" version="1">MDGKDQHADDSAYDQRPPKRARRTPPPAPHLSASQPGYSSSTTSNGHTGTNGASRASPLPPLSLSILGVEPLDEFIREVADWVHHMIGQRPDGAGTVEVEAKIGILRDKATSQRLQLPMLVETILVPNAIDCRFESNMSASQHKHFNTLLNNLKMAPTPASPSPINYAHLHVVDSFYSPDGARGERVRVTRDEKTGTVTACVRKIRLGSLDIYSPKRAADWRISVNVEVPVSMPIGVATLTRKKDRMSYAHEEFIIDLTQVTSTNAGGPKEVLHELEVEVARPEYLLSTAAKRGDPNVSEEERGAFDELIRAFVNNARILVRNAGDGWQHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JCN2</accession>
    <name>A0A2H3JCN2_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_167593</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467931">
        <property type="protein sequence ID" value="PCH37563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JCN2"/>
    <dbReference type="OrthoDB" id="2788229at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH37563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="448" mass="52078" checksum="1BF158040233F15F" modified="2018-01-31" version="1">MTQFICTSVTPEGHNDAVQAFPAAYPLEVEYEILYHLRDQRRLLIVCNAVCRAWRAEIRPYLFHTVRFRRSDVIRWPLQDEDSILFLELIQQSPDIPQYVRRLVLEGSTRYWIEILSQLRSLEDLTITSSTTDGQPVVQSLENMVRYRESLPPIKHLRLHNLRFDYKMTSTLPQFLLGFPKVSTLILQHVRSGMNEDTPPAREILPELENLTMEHSESWAAEWMLHDCPDMRLRNISLVWLDDVEDLFLYQDLLNRSGMMTPEHSAVFMTFIGLPSINEGHQGAHLVEHTARLSSLFAFPDPAQLMQATFSLLNELKQCLGQYIEMEVWTKDIDTLHSMFDWEDLARTIAKLFCYPEDESYDFTFTLIHRLSSGQRDLPPELLEAPLREYLSRERVERIQFWLILSCTIVFFKDQQGNAVRAFNPEVAAKSATEVAPASQDEKIGVLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JCV6</accession>
    <name>A0A2H3JCV6_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tcp11-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_142906</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TCP11 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468053">
        <property type="protein sequence ID" value="PCH40080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JCV6"/>
    <dbReference type="STRING" id="742152.A0A2H3JCV6"/>
    <dbReference type="OMA" id="FEIMELM"/>
    <dbReference type="OrthoDB" id="276323at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010737">
        <property type="term" value="P:protein kinase A signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008862">
        <property type="entry name" value="Tcp11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12832:SF11">
        <property type="entry name" value="LD23868P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12832">
        <property type="entry name" value="TESTIS-SPECIFIC PROTEIN PBS13 T-COMPLEX 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05794">
        <property type="entry name" value="Tcp11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="480"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="79"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="480"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH40080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="732" mass="79699" checksum="ED206FC9CD552790" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JDR4</accession>
    <name>A0A2H3JDR4_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WOLCODRAFT_80416</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="KB467854">
        <property type="protein sequence ID" value="PCH35818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JDR4"/>
    <dbReference type="STRING" id="742152.A0A2H3JDR4"/>
    <dbReference type="OMA" id="CHESSAT"/>
    <dbReference type="OrthoDB" id="292964at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02674">
        <property type="entry name" value="Peptidase_C19R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF95">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="8">
        <location>
            <begin position="19"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PCH35818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="391" mass="44695" checksum="E99909F1F5638D0D" modified="2018-01-31" version="1">MIQSDYPVTYWADIQIRTAGMKNLENMCYMNSTIQCLSATVPFARFFTDGRWKTAVNVMNPMGTKGNLAQAVAYILRDMWQGELQCLSPVTFRRSLCQYAPRFSGTEQHDSQEFLNFLLDGLHEDLNRVLDKTQVESTPEREAELERLPTQIASEQEWQIWRMRNDSLVVDLFHCQCRNRLECLTCHKTSTTYNTFVYLTLPITSSRGLSKISLYHCLDVFVKEEVMEKSDTWNCPRCKMLCKATKNLSLSRLPLVLMIHLKWFSSKGHFTDKIESFVDYPLKGLELASYMLPPLLPGVHARGHKPAHPLRSLLPFPRYLSLAVFHPHPAAPAPSARPARFVLRALAVSTFLQSSESENGMGAPGRKRALRLRDETQSAFDTFAVCKYHSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JEH6</accession>
    <name>A0A2H3JEH6_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CxC2-like cysteine cluster KDZ transposase-associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_86480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468092">
        <property type="protein sequence ID" value="PCH40652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JEH6"/>
    <dbReference type="STRING" id="742152.A0A2H3JEH6"/>
    <dbReference type="OMA" id="WSEHNEA"/>
    <dbReference type="OrthoDB" id="2800500at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040521">
        <property type="entry name" value="KDZ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18758">
        <property type="entry name" value="KDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH40652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="262" mass="29563" checksum="0A38026443160BCB" modified="2018-01-31" version="1" fragment="single">LAILCAACPQPGVNLQDEWEQDTDQCSRWKYNRSMVMDGNFTAEHLRTRRPDDDVWLGDGHGFMVAEARYKIHLAVAKESKQRSTCHDHHAVNQANADRHNLEATGIGAAACGRHGCFFPHSVVDFQKGERQMNMDYVLSQAATSMKGMRKVLLMYDIMCQYRVHLQDHFCDNPYLSIPDGLQIQGGIGQFHVHGHQSECYPRYSPAFMEGAGQLDGEVIETLWAPLNNISGSTRGMSTAHRREVIDDHMNDSKLEEDDWAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JEX7</accession>
    <name>A0A2H3JEX7_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_158009</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467920">
        <property type="protein sequence ID" value="PCH37289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JEX7"/>
    <dbReference type="STRING" id="742152.A0A2H3JEX7"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH37289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="382" mass="41172" checksum="72F203BC544F75F5" modified="2018-01-31" version="1">MLAGPDAIEVHLAELVSKGQRDRRLVESLEVLLAKARKNKKVKSVVFDVPRATLDTMTSAAKCNKSSSADKQGPAGASPKSTLTDGEDATEERAEMPVSMAPLLPKLFAGSQITEVSVETQDKGSSNDRSDGSDEESDENDQESDNNDKESDNHDDTILKNIDPKTLLHGPYSQKSILNQLLSSDSSNHSTDKHDGSDRYEQASSTDDGSDATVEDNEQTYMDADPQDAVEQQDVNLSIAAMLAYSDEQAELEGSATRVVALVPDDQASDETGEDGVMPSSQPSKEHKTSAQTDPIETAEDPDPAAQNTVDDDPIQDVDGFVTPLNEHQLNPPVKTPKSGMIKDRHGRLPKADIQLAAAAQSTPAPMADNEAERHMTWMTTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JFN3</accession>
    <name>A0A2H3JFN3_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WOLCODRAFT_136817</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468053">
        <property type="protein sequence ID" value="PCH40355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JFN3"/>
    <dbReference type="STRING" id="742152.A0A2H3JFN3"/>
    <dbReference type="OMA" id="SEHWREN"/>
    <dbReference type="OrthoDB" id="7130006at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097176">
        <property type="term" value="P:epoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010497">
        <property type="entry name" value="Epoxide_hydro_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016292">
        <property type="entry name" value="Epoxide_hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661:SF35">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661">
        <property type="entry name" value="EPOXIDE HYDROLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06441">
        <property type="entry name" value="EHN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001112">
        <property type="entry name" value="Epoxide_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0058">Aromatic hydrocarbons catabolism</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epoxide hydrolase N-terminal" evidence="5">
        <location>
            <begin position="19"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="328"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001112-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF06441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PCH40355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="416" mass="46634" checksum="2530FEFCC45F54B7" modified="2018-01-31" version="1">MANSDRTDALSTTLLGPEEPFEVHVSDAALELLQQKLGVTRLPDEIEEAGWDYGAPLADIRRLLARWKDGFDWRAAEAKINELPQFTRDIQVDGFGTLNIHYVHQRSTVQNAIPLLFLHGWPGHFLEVQKVLPLLTTASPDHPSFHVVAPSLPNFGFSEAATKPGFGVEQYAEVANRLMLSLGYSEHVVQGGDWGFHISRKLAHVYGHQSVKAWHTNFPNARQPPSLLTHPRQFLAYLFTPYNDRDRAGLARTQWFMNKGRGYFSEQSTKPQTIGYSLADSPVGLLAWIYEKLVQWSDSYSWDDDEVLAWVSVYWFSRAGPAASVRIYYETVTASDYGRSLWSSIPCGLSYFPRELVAVPKTWARTLGNVVFESEHESGGHFAAHEKPHELAADVRAMFGKGGPAFGVVKGRVGYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JFT3</accession>
    <name>A0A2H3JFT3_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WOLCODRAFT_151094</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH41050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JFT3"/>
    <dbReference type="STRING" id="742152.A0A2H3JFT3"/>
    <dbReference type="OMA" id="QTHTHEA"/>
    <dbReference type="OrthoDB" id="2746711at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005162">
        <property type="entry name" value="Retrotrans_gag_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032567">
        <property type="entry name" value="RTL1-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503">
        <property type="entry name" value="LDOC1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503:SF22">
        <property type="entry name" value="TRANSPOSON TY3-I GAG POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03732">
        <property type="entry name" value="Retrotrans_gag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="5">
        <location>
            <begin position="223"/>
            <end position="239"/>
        </location>
    </feature>
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        <location>
            <begin position="171"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="235"/>
            <end position="261"/>
        </location>
    </feature>
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        <location>
            <begin position="73"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="171"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="190"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="237"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH41050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="306" mass="35508" checksum="51778A7DCACFFC2B" modified="2018-01-31" version="1">MQNFINQCNSWFTMYETSFQSDVQRVIFILSYISGKGKTGQWKQNYHRVHTDPMTRRFFPPSLVQFDADFQKAFGAVQEIQKARRQILKLEQDRKDIDDYITEFNNMAGKAQYDRYSPDGNAILVTLFEKGLPEHTTRYIIGMRPMPDNIDAWQEAASYYENTYRIFRRQDRGTPAKKKEWRSNAPRHSGSPSTPQTTPKDPSAMDVDRLTAEERQDHITKGKCFNCHQPGHLSRNCPKKKKGTIRPRGKARKVEESSPEPEVIIEETSDEETEYITANRAVTAIRTLKAKNPELLSQLLEEMDFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JG11</accession>
    <name>A0A2H3JG11_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">AP complex subunit sigma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">WOLCODRAFT_136897</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Adaptor protein complex 2 (AP-2) is a heterotetramer composed of two large adaptins (alpha-type subunit APL3 and beta-type subunit APL1), a medium chain (mu-type subunit APM4) and a small adaptin (sigma-type subunit APS2).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <location evidence="2">Coated pit</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030122">
        <property type="term" value="C:AP-2 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14833">
        <property type="entry name" value="AP2_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000011">
        <property type="entry name" value="AP complex subunit sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016635">
        <property type="entry name" value="AP_complex_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027156">
        <property type="entry name" value="APS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11753">
        <property type="entry name" value="ADAPTOR COMPLEXES SMALL SUBUNIT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015588">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0168">Coated pit</keyword>
    <keyword evidence="6" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="13">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PIRNR" id="PIRNR015588"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH40475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JG41</accession>
    <name>A0A2H3JG41_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="1" type="ORF">WOLCODRAFT_16572</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468053">
        <property type="protein sequence ID" value="PCH40505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JG41"/>
    <dbReference type="OMA" id="WLIETHQ"/>
    <dbReference type="OrthoDB" id="3256444at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH40505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="141" mass="16023" checksum="985048B4DDC30757" modified="2018-01-31" version="1">MPPMLSRRIMAQKNATCASSAGNKSVINEATTIRRHLQAVHSGTYHEWAAKNNFKSMLPNDIEKQKEVKQSDKQTQLDPHLHKRSECIPPYSHLAFRQVAIEWLVSTDWPLQALEHPAFRNMIQIAARATTGVSIPNRKQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JH04</accession>
    <name>A0A2H3JH04_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_163105</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
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            <end position="148"/>
        </location>
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        </location>
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    <feature type="compositionally biased region" description="Basic residues" evidence="1">
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            <end position="255"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468113">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <location>
            <begin position="445"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="573"/>
            <end position="632"/>
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            <end position="66"/>
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        <location>
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            <end position="234"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
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            <end position="346"/>
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            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Barry K."/>
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                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
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                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
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                <person name="Kuo A."/>
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                <person name="Ling A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">MD-104</strain>
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    <dbReference type="EMBL" id="KB468113">
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        <property type="term" value="P:protein localization to plasma membrane"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="EFR3_HEAT-like_rpt"/>
    </dbReference>
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    </feature>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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</entry>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
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                <person name="Salamov A."/>
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                <person name="Sun S."/>
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                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
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            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD-104</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.</text>
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        <property type="protein sequence ID" value="PCH36494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060213">
        <property type="term" value="P:positive regulation of nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045948">
        <property type="term" value="P:positive regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04329">
        <property type="entry name" value="RNAP_II_Rpb7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04462">
        <property type="entry name" value="S1_RNAPII_Rpb7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000043">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.120:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.120">
        <property type="entry name" value="RNA polymerase Rpb7-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036898">
        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045113">
        <property type="entry name" value="Rpb7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005576">
        <property type="entry name" value="Rpb7-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709:SF4">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II, III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03876">
        <property type="entry name" value="SHS2_Rpb7-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88798">
        <property type="entry name" value="N-terminal, heterodimerisation domain of RBP7 (RpoE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase Rpb7-like N-terminal" evidence="7">
        <location>
            <begin position="8"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="6">
        <location>
            <begin position="78"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PCH36494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="170" mass="18881" checksum="CCBF957C9B983895" modified="2018-01-31" version="1">MFFIKELSHTILLHPSYFGPRMLQFLESKLYSDVEGTCSGQFGYIIAVVSILDIGKGMVLSGSGQAEFITRYRAIVFKPFKGEVVDGVVDNVNKMGFFADVGPLKVFVSHQLIHPDLKFDPNSNPPSFASEEQIIEKNTKIRLKIVGTRVDATEIFAIGTIKEDHLGVID</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JIJ9</accession>
    <name>A0A2H3JIJ9_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_20584</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467876">
        <property type="protein sequence ID" value="PCH36504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JIJ9"/>
    <dbReference type="STRING" id="742152.A0A2H3JIJ9"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH36504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="250" mass="29167" checksum="93A45D8455241B39" modified="2018-01-31" version="1">MNLGSGIYTITNVAHLNRAGLPNDNHGESIVGRIPYGNDVALVEQWYLEFSPPSRYIVRNMQYQRYFSTEMCPKPNGAVFGASAHYWWNIDADTLDQDVYRLNHIHQCSIKIFRLMTDPHWRWNRCNSPNKETIAGQLDWRDLPRNYVLQFPQHFSVISLGEVVAEAEADGEFKTNSQMFRLTLCVKDTSAFRTFASSVLHDDEVQVTLQFHTFRFYPADPGDRPSDWNYVYRKPWNKDLVFKGMLLLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JIL5</accession>
    <name>A0A2H3JIL5_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">WOLCODRAFT_143833</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">MD-104</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468124">
        <property type="protein sequence ID" value="PCH42022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JIL5"/>
    <dbReference type="STRING" id="742152.A0A2H3JIL5"/>
    <dbReference type="OMA" id="WSDATCF"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="436"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PCH42022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="506" mass="56187" checksum="D1B3189C09615860" modified="2018-01-31" version="1">MYEFAQSLPLILAMGLVGLAIFYANRQHRPQLPPGPLGLPIVGNALQIPGSRQWLKFAEWAKTYGPIVHVTIFGQHTIILNSREIVSELLEDRSAIYSERPHFRMAGDLMGFSEFIFLLPNGDRLRQSRSHSSIGISHTLEQKVVKFANELSRSPEHFQSHIETYVAGIILQIIHGHKVEDHEDDLLSLAQQLNKIFHAGIAAGAWWVDSIPILQYVPSWIPGAGFKRKAREWRKVMERFRDEPYDLVKAQATQGTAQPSMTRELVVGNVDDDPGMESLNKYISSAVYGAGADTSVSAIESFFLAMSLHPEVQSKAQAELDYVLGPGILPKVSDRHNLPYVAALLQEIHRWNPVAPLGMRQSPSGLPHAVAQDDYYGDYLIPAGSTVVANIWALLHDSALYPNPMEFFPERFLDKSDADINPDPRLDAFGYGRRVCPGKNLADDTLFMAVATVLALFTINKPIGPDGSIIEPTVDYSGSISHNVPFGCRIVTRSEDIAQFLRAMDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JIU5</accession>
    <name>A0A2H3JIU5_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">L domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WOLCODRAFT_134292</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467887">
        <property type="protein sequence ID" value="PCH36604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JIU5"/>
    <dbReference type="STRING" id="742152.A0A2H3JIU5"/>
    <dbReference type="OMA" id="RFCAWSG"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053211">
        <property type="entry name" value="DNA_repair-toleration"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48060">
        <property type="entry name" value="DNA DAMAGE-REPAIR/TOLERATION PROTEIN DRT100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48060:SF18">
        <property type="entry name" value="PROTEIN KINASE, PLANT-TYPE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PCH36604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="482" mass="50761" checksum="AE679199B1DCA5BD" modified="2018-01-31" version="1">MAPDRISRIHSNDSEGQEPAEGLSTIASRAPSTWTNTATVKNSVADVEAVTPATGHGSRFRERFTRIFSDVGTIAGNEEADDATIQPSSLPAWPPLNIEKRPPQCCEHCPRQRKQRKRDKLLIALLIILLLYFLGNIVALNIRTFTTSSGTTTSHIGTSDSVALTADQQFCLSDFTINTPGNASSYPCSTCFGILQGVSSAFLDSSSNAQDAQNIANAIQFCALRSVFDEADADGQSTLGTEGWATNVNFCTWTGVKCNANGDVTSLQLTFPGVPATFSSEIGGLTSLESFEVVGNSDIPAGALPSSFTNLTALLTLELQATAITALQDDLFSSLKNVTTLSLVRNAKMGTSLPTSLTSLPLENLIVTNQALSNPLATLANSSTLQSSLKLLDLSTTNLTGTIPASISSLSALVELHLDTNDLSNPLPSAFPSNLQILTLANNTQLSGTVSGSFCSLKDLQLCDMDGTSLQAAGSCSVCTFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JJG9</accession>
    <name>A0A2H3JJG9_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Terpene synthase</fullName>
            <ecNumber evidence="6">4.2.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WOLCODRAFT_72514</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD-104</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the terpene synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.-" evidence="6"/>
    <dbReference type="EMBL" id="KB468124">
        <property type="protein sequence ID" value="PCH42336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JJG9"/>
    <dbReference type="SMR" id="A0A2H3JJG9"/>
    <dbReference type="STRING" id="742152.A0A2H3JJG9"/>
    <dbReference type="OMA" id="CKMTKEF"/>
    <dbReference type="OrthoDB" id="2861623at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010333">
        <property type="term" value="F:terpene synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034686">
        <property type="entry name" value="Terpene_cyclase-like_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35201:SF4">
        <property type="entry name" value="BETA-PINACENE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35201">
        <property type="entry name" value="TERPENE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19086">
        <property type="entry name" value="Terpene_syn_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01020">
        <property type="entry name" value="Terpene_Cyclase_Like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PCH42336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="338" mass="39007" checksum="6707DA1F9C29E97C" modified="2018-01-31" version="1">MSAPTFFTLPDLLPFLPFKGSFNPHFQDAAGASSKWASSFRIFSDRKRENFQQSGSELLCAHAWPYAGYEELRTCCDFVNTLFAVDEISDEQTGKDAYSTGRVFYNALSNPEWDDGSALSKMTKEFRTRLLKKNVPACHRRFVQHCEDYVNAFAVEAELREQKKVLELDSYMVLRRENSAIRTCFGLFGYVLGVDLPDEIFEHPIFMRMHIAAVDMVAWSNDVYSYNMEQAMGHTGNNVVTVLMNQNNWDLQTAVDHVGVHFKELMDSFMADKARLPSWGPKLDSAVSQFVMAMENWVVGNCEWSFETQRYFGTERAEIKRTRVVRLYPKREKEDEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JJI1</accession>
    <name>A0A2H3JJI1_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HIT-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WOLCODRAFT_38419</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD-104</strain>
        </source>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="zf-HIT_ZNHIT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Vps71/ZNHIT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007529">
        <property type="entry name" value="Znf_HIT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13093">
        <property type="entry name" value="ZINC FINGER HIT DOMAIN CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04438">
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        <property type="match status" value="1"/>
    </dbReference>
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            <end position="157"/>
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        <location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
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        <location>
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        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
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        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PCH42332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="162" mass="18168" checksum="FA5E870F8AE05511" modified="2018-01-31" version="1" fragment="single">RQAQSSSTQLDPEVIAKRTKRHLDELERSNYSEPSGALFPGLDDDDDAPGGRSAKGRARQTISDKREWPGLHKKKSTMAVRTAVLYRKNFATLVDESGIAGYPPDVPTYLTAVVPPPREPPRLLCSVCGYWGKYKCQRCAMPYCDLNCEAVHNETRCERRVV</sequence>
</entry>
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    <accession>A0A2H3JJM2</accession>
    <name>A0A2H3JJM2_WOLCO</name>
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        <submittedName>
            <fullName evidence="1">DUF431-domain-containing protein</fullName>
        </submittedName>
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        <name evidence="1" type="ORF">WOLCODRAFT_167172</name>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
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                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
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                <person name="Stenlid J."/>
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                <person name="Wiebenga A."/>
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                <person name="Eastwood D.C."/>
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                <person name="Cullen D."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH36884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="219" mass="24712" checksum="2ABD460CCED0BAFE" modified="2018-01-31" version="1">MAFTYVVEHMEEDEESSKAIPRWVELEYMHMRSLAGTGAHVEFTHLSQSSCKTLSSLFSDTAEREDTAEASTHTISVMELMKQRGVPIEKVCLLDPRAEKELSPSDGDGEFEWFLFGGILGDDPPRDRTGELRVLGFPNRHLGPVQMTTDTALGVTKLVVQDKIPLSKIPYVDHPTIVFNSKESVEMPFKYIADKRGEPILPPGMREHLQEDLNKSFDF</sequence>
</entry>
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    <accession>A0A2H3JJP8</accession>
    <name>A0A2H3JJP8_WOLCO</name>
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        <recommendedName>
            <fullName evidence="8">Dbl homology domain-containing protein</fullName>
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        <name evidence="6" type="ORF">WOLCODRAFT_25360</name>
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        <lineage>
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        </lineage>
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    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
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                <person name="Martin R."/>
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                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
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                <person name="Sabat G."/>
                <person name="Salamov A."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD-104</strain>
        </source>
    </reference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
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        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041675">
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        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052233">
        <property type="entry name" value="Rho-type_GEFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572">
        <property type="entry name" value="RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572:SF1">
        <property type="entry name" value="RHO1 GUANINE NUCLEOTIDE EXCHANGE FACTOR TUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="4">
        <location>
            <begin position="48"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="272"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="CNH" evidence="5">
        <location>
            <begin position="437"/>
            <end position="748"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PCH42416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="795" mass="90954" checksum="07491CF122EAC670" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-05-03" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JJV6</accession>
    <name>A0A2H3JJV6_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_17738</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468124">
        <property type="protein sequence ID" value="PCH42450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JJV6"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH42450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="162" mass="17190" checksum="DCDB910E6C8EE043" modified="2018-01-31" version="1">MSHSACRCSFAIQGSYSAAILLDVNIASPAAASMSEITICAPMSLQEMATGILCDYSNSSPLPDNLAADTIPHEDDNAYYVTDWRAFIIVNVVGYTTGFWASTNSTNLLETQAIGIDQHDSGVIESNSPENSQGQISLQFASRIVGSIGALLDYEGMESPIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JJZ3</accession>
    <name>A0A2H3JJZ3_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_29771</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467957">
        <property type="protein sequence ID" value="PCH39119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JJZ3"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH39119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="119" mass="12647" checksum="20113FD14D408994" modified="2018-01-31" version="1">MDAPCPLTRTSSTTRVVPSGPVNPIVLLVTAPMFASTLAPPISCCTLHCRPCHRRHHDPPAPAVCASSRCMPPPLCVCMSRCCSWINAAFASANQPWTSRCIFGTVRCATCTGHSILAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JK87</accession>
    <name>A0A2H3JK87_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Actin depolymerizing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WOLCODRAFT_136070</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD-104</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Interacts with G-actin; ADP-actin form.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin-binding proteins ADF family. Twinfilin subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH38158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JK87"/>
    <dbReference type="STRING" id="742152.A0A2H3JK87"/>
    <dbReference type="OMA" id="YLFKHTH"/>
    <dbReference type="OrthoDB" id="10006997at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003785">
        <property type="term" value="F:actin monomer binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030042">
        <property type="term" value="P:actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11284">
        <property type="entry name" value="ADF_Twf-C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11285">
        <property type="entry name" value="ADF_Twf-N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000042">
        <property type="entry name" value="Actin depolymerizing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028458">
        <property type="entry name" value="Twinfilin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13759">
        <property type="entry name" value="TWINFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13759:SF1">
        <property type="entry name" value="TWINFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ADF-H" evidence="9">
        <location>
            <begin position="6"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="ADF-H" evidence="9">
        <location>
            <begin position="176"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="324"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PCH38158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="353" mass="37633" checksum="4E2AE8E06B5FE742" modified="2018-01-31" version="1">MSAPTGIAVSQELSSTFADAVESKDVRFLKVSIRNESLVPDGTTPPSGTLEADLDNLGSILDDNAPAYVLVRLDDPPSEWLAVYYVPDTAQVRDKMLYAATRNTLTKSLGSAHFTDQIFATTKDDLTANAYAKHKQHLAAPKPMSAREKEMEAVKAAERSGNYEGSRARATHVPQTVGLKWSEEVENAVKNLGSGDGGYLVLVTIDTATETLQLSSEAECNVDDLGSALPVSDPAYAFFAWPQEITSPPRRDIVFIYSCPSSSPIKHRMLYSSGCAVLVNQAKEILAASGSESKVASRRVETSDPSELDGSFLALSLGLTDGAEAGNPRAAAPTAAGEKAAFARPKGPGRRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JK98</accession>
    <name>A0A2H3JK98_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">NAD(P) transhydrogenase, mitochondrial</fullName>
            <ecNumber evidence="5">7.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="23">Nicotinamide nucleotide transhydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">WOLCODRAFT_23128</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27 28">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="20">The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane. May play a role in reactive oxygen species (ROS) detoxification in the adrenal gland.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>NAD(+) + NADPH + H(+)(in) = NADH + NADP(+) + H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:47992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="7.1.1.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="21">In the C-terminal section; belongs to the PNT beta subunit family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the AlaDH/PNT family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.1" evidence="5"/>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH38168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JK98"/>
    <dbReference type="STRING" id="742152.A0A2H3JK98"/>
    <dbReference type="OMA" id="EQCREVD"/>
    <dbReference type="OrthoDB" id="37244at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008750">
        <property type="term" value="F:proton-translocating NAD(P)+ transhydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006740">
        <property type="term" value="P:NADPH regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05304">
        <property type="entry name" value="Rubrum_tdh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000028">
        <property type="entry name" value="NAD(P) transhydrogenase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1220:FF:000002">
        <property type="entry name" value="NAD(P) transhydrogenase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008143">
        <property type="entry name" value="Ala_DH/PNT_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008142">
        <property type="entry name" value="AlaDH/PNT_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007886">
        <property type="entry name" value="AlaDH/PNT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007698">
        <property type="entry name" value="AlaDH/PNT_NAD(H)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026255">
        <property type="entry name" value="NADP_transhyd_a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024605">
        <property type="entry name" value="NADP_transhyd_a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034300">
        <property type="entry name" value="PNTB-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00561">
        <property type="entry name" value="pntA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006942">
        <property type="entry name" value="PRK09424.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10160">
        <property type="entry name" value="NAD(P) TRANSHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10160:SF19">
        <property type="entry name" value="PROTON-TRANSLOCATING NAD(P)(+) TRANSHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01262">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05222">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02233">
        <property type="entry name" value="PNTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12769">
        <property type="entry name" value="PNTB_4TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01002">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01003">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00836">
        <property type="entry name" value="ALADH_PNT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00837">
        <property type="entry name" value="ALADH_PNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="18 24" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-0521">NADP</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="13" id="KW-1278">Translocase</keyword>
    <keyword evidence="8 24" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 24" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="500"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="528"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="556"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="592"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="617"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="646"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="671"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="702"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="735"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="776"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="799"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="829"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="853"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="domain" description="Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal" evidence="26">
        <location>
            <begin position="74"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding" evidence="25">
        <location>
            <begin position="219"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00054910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00061558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00074145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00079255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="SMART" id="SM01002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="SMART" id="SM01003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="PCH38168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="1079" mass="112094" checksum="A33BDED5EC684508" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JK99</accession>
    <name>A0A2H3JK99_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_152015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
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                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD-104</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468135">
        <property type="protein sequence ID" value="PCH43102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JLM4"/>
    <dbReference type="STRING" id="742152.A0A2H3JLM4"/>
    <dbReference type="OMA" id="HVGTTWH"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF78">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="4">
        <location>
            <begin position="278"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="537"/>
            <end position="538"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PCH43102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="603" mass="66124" checksum="3F4DD7B95142F72D" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JMB1</accession>
    <name>A0A2H3JMB1_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_152670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468124">
        <property type="protein sequence ID" value="PCH42635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JMB1"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH42635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="283" mass="33033" checksum="FF5F8F3C89476FB9" modified="2018-01-31" version="1">MPADQYQESAKKVEAGFRLQTRKDLFRKEKKPYQSQAAPPNKQVVTNAATGVPELWDIPSWSIKRVKELIPDNKYRGPSWNPAAAPKKVVVQHTEEERQALLKQRYNEFDRLREEAEWHRALRASERRLESAAEQAYLDKVVATYPGYHPTPVTPASLLDRVISKETAARIAKEVRLEPEWVADHFHLLPDDTERDRIAIMYKKYKWALCLLPILEETEQILGKLYILILDDPSPFYQEPASQAVVHQIQRYHAFFERFFLQTLYGHVSNKELREIERDANAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JMB7</accession>
    <name>A0A2H3JMB7_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">E2 ubiquitin-conjugating enzyme</fullName>
            <ecNumber evidence="2">2.3.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">E2 ubiquitin-conjugating enzyme 7</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Ubiquitin carrier protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Ubiquitin-protein ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">WOLCODRAFT_138163</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.</text>
            <dbReference type="EC" id="2.3.2.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="2"/>
    <dbReference type="EMBL" id="KB468135">
        <property type="protein sequence ID" value="PCH43021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JMB7"/>
    <dbReference type="STRING" id="742152.A0A2H3JMB7"/>
    <dbReference type="OMA" id="APDGMFT"/>
    <dbReference type="OrthoDB" id="19692at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23796">
        <property type="entry name" value="UBCc_UBE2G2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000008">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 G2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0882">Thioester bond</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="13">
        <location>
            <begin position="9"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="11">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00077195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PCH43021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="172" mass="19270" checksum="00AF949876DDBD4D" modified="2018-01-31" version="1">MNSRSGNATALRRLMTEYKQLTSQGAPDGMFTAGPVSEDDFFQWEALIMGPKDTPFEGGVFPARLTFPSDYPLSPFKMRFDPPLFHPNIYPDGTVCISILHAPGDDPTMYESASERWSPVQSVEKVILSVISMLAEPNLESGANIDCCKLYRDNRAEYERIVRQSIQEQLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JMJ3</accession>
    <name>A0A2H3JMJ3_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Xylitol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WOLCODRAFT_24495</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD-104</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH41103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JMJ3"/>
    <dbReference type="STRING" id="742152.A0A2H3JMJ3"/>
    <dbReference type="OMA" id="FETWYAM"/>
    <dbReference type="OrthoDB" id="2148442at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003939">
        <property type="term" value="F:L-iditol 2-dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006062">
        <property type="term" value="P:sorbitol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05285">
        <property type="entry name" value="sorbitol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000068">
        <property type="entry name" value="Sorbitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045306">
        <property type="entry name" value="SDH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF9">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="8">
        <location>
            <begin position="11"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PCH41103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="376" mass="40045" checksum="C7C1CF4F21A2B2E6" modified="2018-01-31" version="1">MSDNPSFVLRGVEDVVYEQRPVPEIRDDEVLIEVKKTGICGSDVHYLVAGRIAQFVVEKPMVLGHESAGVVAKIGAKVKTLKVGDRVALEPGATCRVCDACKSGRYELCPDMVFAATPPYDGTLARYYPIPADICYKLPDHLTLEDGAMMEPLSVAIHAVANIAQLRPNQSVAVFGAGPVGLLCMAAARALGASRVIAVDIVPHRLEFARSYAATEAYLPPAPEAGESRIRYSERNAKLMMQTLGIAERGPTAIDLVVDASGAEVSIQTGIIIAKAGGTFVQLGMGSPEIVIPVTTLLTKELNFKGSFRYGPGDYPLAIALVSQGKIDLKPLVTHRFSFDQAIEAFQTTRVGKSADGKGVIKAVISGPDVSPDDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JMK6</accession>
    <name>A0A2H3JMK6_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_135893</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH37874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JMK6"/>
    <dbReference type="OMA" id="RTGGINS"/>
    <dbReference type="OrthoDB" id="3256525at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH37874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="405" mass="45687" checksum="5EE2A5D8E1D2391C" modified="2018-01-31" version="1">MSSVSVLLPVELWLYIFRLSTISSETRKLHATTYRPFDTTKVDAVDVAVTRTKAALVRVCKQWRAWAMELLYEDLLLRSPKKLPQVSLHDVAAREAAASNPCVEPAHCGRWVRRACLPYCCSSTPSYRPPKALQILEQCPRLEVLVRTGPFSHPDADMRFEFSTSCPPLPALKRLDWWHDNEAARAGGINLLGDVLLAAPNLQYLSVGGRVHFSHVAPRPPDLPKLATLRVLQGTSVQLVGQLSRWSLPSLRHLVLDGAEPNILEFLWEAFGAQLRTIELGESLCFAAPDARTLARILESCPQLEELNYHVFMTAVPAPFREEEKFDTITTVGLHAQPSSLVPQGSTEFWQQIQGHFDMLYRPNLSALRKIVLYDDWDMVANDCRYLSLIQPLLDRRVTIERASD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JN01</accession>
    <name>A0A2H3JN01_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cell wall mannoprotein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_135997</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="PCH38024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="742152.A0A2H3JN01"/>
    <dbReference type="OMA" id="DLGCIFS"/>
    <dbReference type="OrthoDB" id="2153847at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053216">
        <property type="entry name" value="Appressorial_penetr-assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34587:SF1">
        <property type="entry name" value="CIRCUMSPOROZOITE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34587">
        <property type="entry name" value="VWFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013897640" description="Cell wall mannoprotein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH38024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="374" mass="36994" checksum="1362D24D6D60F583" modified="2018-01-31" version="1">MLSYKFLGLALVVSAWALPFKREVPQEHSHNIVLASVRPMLDLNNPNNIEDPVFGLLGDAAAAAGAGSITNLDCLQQATADQAFTNAKAAGNVTGMAFSLIYRAIERNTGAVGLASVICNETATNPEIAALTQHQDPASTNASAINKAITLELAKQIASVGGDPTLALISGTFAPGQIGDPTAKGNTCDVEDDEPGCIFSQNLLVEDATTAEISAAVAGISATATSAAAASATSAAASAASAADDETATCASIVTVTVTASATATAATEIASAATSAAATATATATASATGTNLQTFTGALGGVTAPSVIAAGSGFEVTTEPEDPFVNLAAALGRSCDIQHNQCADAANSSGNSAFTVGDCDTQDTQCKAASSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JN40</accession>
    <name>A0A2H3JN40_WOLCO</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">WOLCODRAFT_158695</name>
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    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
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            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467965">
        <property type="protein sequence ID" value="PCH39158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JN40"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013682298" evidence="2">
        <location>
            <begin position="16"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH39158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="284" mass="30981" checksum="19A27A5C73E74C0F" modified="2018-01-31" version="1">MSCGHVLLFLDIILAITCIIQSPSVRWHSLTADASGHLPMPRQPDSSDAHLLRTFQPHCVLPPARFLPPTIHVPPPASCPRAASSLPSARRCPPSVRPPPPTYRLHTAARLLSMRHRPPPIHAPLPACRLRTVLTSCPRAATLLSSAHRHPPPIHASLPTSCPRATTLLLSARRRPPAVCALSPPPVHAPLPSCRLHAAARLLSTHRRPPVICTPPPAFRLHAAARLPSAHHHPPPVHMPPLTCCPRAAHLRSMCRRSPVACVPTLPMEQFSVCRARRLYAQRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JNB8</accession>
    <name>A0A2H3JNB8_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Heme oxygenase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WOLCODRAFT_117037</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468053">
        <property type="protein sequence ID" value="PCH40299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JNB8"/>
    <dbReference type="STRING" id="742152.A0A2H3JNB8"/>
    <dbReference type="OMA" id="TEQLWFV"/>
    <dbReference type="OrthoDB" id="652091at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004392">
        <property type="term" value="F:heme oxygenase (decyclizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006788">
        <property type="term" value="P:heme oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19165">
        <property type="entry name" value="HemeO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002051">
        <property type="entry name" value="Haem_Oase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016053">
        <property type="entry name" value="Haem_Oase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10720">
        <property type="entry name" value="HEME OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10720:SF0">
        <property type="entry name" value="HEME OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01126">
        <property type="entry name" value="Heme_oxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PCH40299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="321" mass="34797" checksum="205A42309A2BB2AC" modified="2018-01-31" version="1">MDYSLPLATLLRTSTAAAHNAVEKTQGAGWLARGELDQDEYARLLMMLWHVYDAIERAYDEHQSHPVLSHTYNSPLLARAPLLSADISYYLDTDESTWRSHPAHVALMASPPSALSRYLARIQDIAQSADPSPLLAHAYVRYLGDLSGGQVIRNRIVKSYGLSDGRGVAFYEFKSLGGTGPATIGDMKKIKEWYRGSMNSSVGDNQALKAAIVEEANVAFELNGGLFAALKAPRLSVSTTPALPLLGEPSTPVISSIDDKAVEESGKVVFEQSEPEKTYQLSSVLAVVAAMSLAHFLLVVGGFTGDRGLAKLQALKDWLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JNN8</accession>
    <name>A0A2H3JNN8_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">TPR-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WOLCODRAFT_138588</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
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            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD-104</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
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        <text evidence="3">Belongs to the peroxisomal targeting signal receptor family.</text>
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        <property type="protein sequence ID" value="PCH43796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="742152.A0A2H3JNN8"/>
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    <dbReference type="OrthoDB" id="10006023at2759"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PEX5/PEX5L"/>
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        <property type="entry name" value="TPR-like_helical_dom_sf"/>
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        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10130:SF0">
        <property type="entry name" value="GH08708P"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TPR_8"/>
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        <location>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
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                <person name="Barry K."/>
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                <person name="Benoit I."/>
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                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
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                <person name="Kallen N."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
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    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
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<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
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                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
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                <person name="Benoit I."/>
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                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
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                <person name="Kohler A."/>
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                <person name="Martin R."/>
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                <person name="Morgenstern I."/>
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                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
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                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="entry name" value="NAC-like_UBA"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="52"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH37927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="91" mass="10288" checksum="540F023799FF7173" modified="2018-01-31" version="1">MSRTNGRPEPEVIVNFADGYAYSKGKMEEAFRSGLMDRPAVKPAEKLSHKAKQEDVDLLVHELDVTRSQAEKMLLENDNDIAQVLTEWVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JPR2</accession>
    <name>A0A2H3JPR2_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Clavaminate synthase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_116093</name>
    </gene>
    <organism evidence="1 2">
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        <name type="common">Brown rot fungus</name>
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        <lineage>
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            <taxon>Agaricomycotina</taxon>
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            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468053">
        <property type="protein sequence ID" value="PCH39728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JPR2"/>
    <dbReference type="OMA" id="RPRFMAQ"/>
    <dbReference type="OrthoDB" id="4664297at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH39728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="335" mass="37946" checksum="9D4340537BC0F530" modified="2018-01-31" version="1">MTKQFKYLTQEQVDFFMENGYIILKQAFTREKAAEWTKDMWTRLALDPNDKSTWNRERIHMPWHKREAVSTFAPKAWDAMKDLLGGEERIDEASSTWGDSFIVNLGTPELEGPDKHIAPQDLDNWHVDGDFFVHFLDSPEQALLVIPLFSDIKPRGGGTFISPDGIDLIAPYLAAHPEGVLPTGLSFTPSTTTAAEPQDDPHYWSHLKEVKRCKRFVEVSGEVGDVVLLHPLMLHTASKNHLREVRVITNPPVGLKEPFNFARDDPSEYSLVELKTLKALGVDRFEFKPTTERRRVVPRRVALQQKMLEDEKKRLEALSKASSAPANVAPPIAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JQU6</accession>
    <name>A0A2H3JQU6_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cytochrome c oxidase subunit 8, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Cytochrome c oxidase polypeptide VIII</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WOLCODRAFT_162868</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Mitochondrion inner membrane</location>
            <topology evidence="1 7">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the cytochrome c oxidase VIIc family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH41179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JQU6"/>
    <dbReference type="STRING" id="742152.A0A2H3JQU6"/>
    <dbReference type="OMA" id="RSMHGEY"/>
    <dbReference type="OrthoDB" id="9974841at2759"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.49.10">
        <property type="entry name" value="Cytochrome c oxidase subunit VIIc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004202">
        <property type="entry name" value="COX7C/Cox8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036636">
        <property type="entry name" value="COX7C/Cox8_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02935">
        <property type="entry name" value="COX7C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81427">
        <property type="entry name" value="Mitochondrial cytochrome c oxidase subunit VIIc (aka VIIIa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU368123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PCH41179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="89" mass="9698" checksum="C3E231E0F143F172" modified="2018-01-31" version="1">MANGARLFSHAPRLRTMTLLARAGVPLRQAARRSPIATPARFSHGHAEFSPVPFTYKNRKLFAAKVAAYLVGGFAIPFVAAAYQLRKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JQZ1</accession>
    <name>A0A2H3JQZ1_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_57317</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468157">
        <property type="protein sequence ID" value="PCH44351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JQZ1"/>
    <dbReference type="STRING" id="742152.A0A2H3JQZ1"/>
    <dbReference type="OMA" id="YEQRNDK"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="195"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="195"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="222"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH44351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="260" mass="29726" checksum="E0BFE34F2557AABF" modified="2018-01-31" version="1" fragment="single">TRKEKVPPPPEFSGADGKVQAKEWIEKLGLYFAKVKPADDEERITTALYRLSGEAYRFMGPLLEKAGNGEPLGTWADFKKQILNQYAKKMDKEIAEKEIKAFYGSNGKKKVETNFFTYCSKFRTLGRLSEIDGTTLLREFKEVLPEKVRDHVAILTRVTPAAIPADWDKYVDLCLELYKIAYPDKLDGSIFKEEKKEKKEEKKEQPKETAQKKAHSKGKGKATSTSTEQKSTENTEQVCSYCKQKGHFFKSCSKLKKDKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JR75</accession>
    <name>A0A2H3JR75_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WOLCODRAFT_26919</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB468168">
        <property type="protein sequence ID" value="PCH44646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JR75"/>
    <dbReference type="OMA" id="EMTFYTG"/>
    <dbReference type="OrthoDB" id="196103at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010291">
        <property type="entry name" value="Ion_channel_UNC-93"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051617">
        <property type="entry name" value="UNC-93-like_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294:SF17">
        <property type="entry name" value="DUF895 DOMAIN MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294">
        <property type="entry name" value="ET TRANSLATION PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05978">
        <property type="entry name" value="UNC-93"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="271"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="301"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="351"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="410"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PCH44646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="472" mass="51014" checksum="B5B093FCBF335442" modified="2018-01-31" version="1">MAHLLKLPAFYTTPMAQVILVGITCFATVGMFQAVSNLGAGGTENLTLSDTSNGVLYGCFAVAGCFSGGINNVLGPRLTLFIGTFGYALYLGALWCYQARGVSWFLIFAGAILGFTAAMLWSAQGSIMMSYPLERDKGRAFGYFWAIFQLGTLIGAIIAFAINVRRGGLGSVSTGTYLAFLIIIAFGIASALLILPPDRIVRADGTRVALKAHATPRQEIVGMWHTLKDWRVLALLPMWFASNYFYAYQGALNTARFDDATRALNAVLEGAGAIVGALLIGIFVLDSPFPRLQIARRKRGYLGLGVVVLATSGVWACGVAWQATFNRADAAAEPLINYHDKAYRDKAPLFFFYYFADACYQALAYWIMSALTNDPFKLARLAGLYKAVQSAGAAGSFGMDAVKTPFLNEILASWLMMVASFPLAFLVLRTVKETSYDDDDVVYVDDAKRDSDAYSVEKVPAGESVQIGAAMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JR76</accession>
    <name>A0A2H3JR76_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Orc1-like AAA ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_165311</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468168">
        <property type="protein sequence ID" value="PCH44670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JR76"/>
    <dbReference type="OMA" id="ESNTAVW"/>
    <dbReference type="OrthoDB" id="431454at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47691:SF3">
        <property type="entry name" value="HTH-TYPE TRANSCRIPTIONAL REGULATOR RV0890C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47691">
        <property type="entry name" value="REGULATOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orc1-like AAA ATPase" evidence="1">
        <location>
            <begin position="63"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH44670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="797" mass="87480" checksum="16575E4F2E5F0249" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JRK0</accession>
    <name>A0A2H3JRK0_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">aspartate kinase</fullName>
            <ecNumber evidence="2">2.7.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WOLCODRAFT_27042</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aspartokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.4" evidence="2"/>
    <dbReference type="EMBL" id="KB468168">
        <property type="protein sequence ID" value="PCH44782.1"/>
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        <source>
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        </source>
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</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JRX8</accession>
    <name>A0A2H3JRX8_WOLCO</name>
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            <fullName evidence="7">Protein root UVB sensitive/RUS domain-containing protein</fullName>
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        <name evidence="8" type="ORF">WOLCODRAFT_154740</name>
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        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
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        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
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                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
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                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD-104</strain>
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            <location evidence="1">Membrane</location>
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    </dbReference>
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        </location>
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        </location>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="453" mass="48574" checksum="C47E81D9C9B58968" modified="2018-01-31" version="1">MGWRRFLSNIFLPAGYPASVSSVLEGESRALLLLGINPDIADLSGHGVGKADASATHAILLTVLQEIFSRLTTVVAGYYLGTSLYPEAKTYRLLADIFNDASIVLDTLSPHLSAVVLSAQYPFARAGSGSALRVAALCASGASRALCAAVAGGSKAALTLHFASSGAINGDVGDLNAKDASKETILALLGMLCGTGVMHYVHSTHATYIVLFTLLFFHLLWNYLAVRVVVLRSLNRQRASIVWSAYSARRNKAFGTPGSSVPRVLTPKAVAQHERIFANPSALYDTSTHAKLFLGSCHIGSAFSSISPNASLSYSSTPHLTLAQLTSLLETLSSEQYLLWYSPPTRSSSHLSLHILMKPHHRPSDHLKAWAHAYEAARLLVGRAPNDFEVGLAAVQTARAVVEEAWEDFIEGVREAGWKLAEGEGGLVGVGRTIQVEVQESAKDEINEDRKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JS18</accession>
    <name>A0A2H3JS18_WOLCO</name>
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        <recommendedName>
            <fullName evidence="6">Restriction endonuclease type IV Mrr domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="4" type="ORF">WOLCODRAFT_139331</name>
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    <organism evidence="4 5">
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
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                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="entry name" value="RRG7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28133">
        <property type="entry name" value="REQUIRED FOR RESPIRATORY GROWTH PROTEIN 7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28133:SF1">
        <property type="entry name" value="REQUIRED FOR RESPIRATORY GROWTH PROTEIN 7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="137"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="207"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="265"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="151"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="213"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="267"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="285"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PCH44942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="314" mass="33799" checksum="C5E982F6E9C7AC0B" modified="2018-01-31" version="1">MSLRRVGGRGDGGIDLLGWWWLPTDSNDQSSIPREDVKAAALSGQRRRIRIIAQCKDEKQSTGPKYVRELEGVLFRYLLRVQTPHLNSTIASFAKAAPVSSASVEVTKKKKTTRKKETGAAVSEGASLREDMLVSLSTSPPTEDAKPPMEGEAESPNEFDQADSGPVVGLLITSAPFTKACLLRAHSSPLPLMLLHIPPVPRPLSSAIRSAETAPSATSSKFEENSSIDADLEPEPPSALGALMFNPALGSASGLLRGRVQPRWEHPSLTTSPSASGPSPSLLGESHRAKTERPGLWYDGKRIESWTPHKAEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JS22</accession>
    <name>A0A2H3JS22_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Protein transporter SEC24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WOLCODRAFT_129293</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC23/SEC24 family. SEC24 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB467998">
        <property type="protein sequence ID" value="PCH39444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JS22"/>
    <dbReference type="STRING" id="742152.A0A2H3JS22"/>
    <dbReference type="OMA" id="INPFMTF"/>
    <dbReference type="OrthoDB" id="49016at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1670">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.730">
        <property type="entry name" value="Sec23/Sec24 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012990">
        <property type="entry name" value="Beta-sandwich_Sec23_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006900">
        <property type="entry name" value="Sec23/24_helical_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036175">
        <property type="entry name" value="Sec23/24_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006896">
        <property type="entry name" value="Sec23/24_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050550">
        <property type="entry name" value="SEC23_SEC24_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006895">
        <property type="entry name" value="Znf_Sec23_Sec24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803">
        <property type="entry name" value="SEC24-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803:SF4">
        <property type="entry name" value="SECRETORY 24CD, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08033">
        <property type="entry name" value="Sec23_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04815">
        <property type="entry name" value="Sec23_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04811">
        <property type="entry name" value="Sec23_trunk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04810">
        <property type="entry name" value="zf-Sec23_Sec24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81811">
        <property type="entry name" value="Helical domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Zinc finger Sec23/Sec24-type" evidence="5">
        <location>
            <begin position="128"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 trunk" evidence="6">
        <location>
            <begin position="225"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 beta-sandwich" evidence="8">
        <location>
            <begin position="480"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 helical" evidence="7">
        <location>
            <begin position="576"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="4">
        <location>
            <begin position="716"/>
            <end position="765"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PCH39444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="850" mass="93665" checksum="6B50E2FCE8CD4322" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JS45</accession>
    <name>A0A2H3JS45_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_84644</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467943">
        <property type="protein sequence ID" value="PCH38847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JS45"/>
    <dbReference type="OMA" id="DVCQAKA"/>
    <dbReference type="OrthoDB" id="809632at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05288">
        <property type="entry name" value="PGDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041694">
        <property type="entry name" value="ADH_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045010">
        <property type="entry name" value="MDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205:SF7">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16884">
        <property type="entry name" value="ADH_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="2">
        <location>
            <begin position="28"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH38847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="344" mass="37115" checksum="C0CDBF26C53E74B3" modified="2018-01-31" version="1">MAPIINGRLLFNQLPNGLPVPGKTTVYDASETIDLETAPLNGGILVKILVLSADIYIISRMRDSSVEGRSSPFLLNQPIDNYGVGLVLRSEHSSFKQGDHIYGMLPFQQYIVMPPATAERFTVLSNDAGIPWSAYVGVCGMPGQTAHHGWREFSKAKVGETVFVTSGAGPVGATVIQMAKAEGLKVIASAGSDEKVAFIKSLGADVAFNYKTEDTREILAREGPIDVYWDGVGGEALEAAIDAASVGARFIECGMISVFTGEPYHVKISFNIVTKELKISGFIVTSLHQAHLSHFYETFPKLVKEGKIKYKEDVTQGLERAGHAIVDVITGRNKGKSVILVGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JSW7</accession>
    <name>A0A2H3JSW7_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">E2 ubiquitin-conjugating enzyme</fullName>
            <ecNumber evidence="1">2.3.2.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WOLCODRAFT_138164</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="1"/>
    <dbReference type="EMBL" id="KB468135">
        <property type="protein sequence ID" value="PCH43023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JSW7"/>
    <dbReference type="STRING" id="742152.A0A2H3JSW7"/>
    <dbReference type="OMA" id="MFEWEVM"/>
    <dbReference type="OrthoDB" id="19692at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23795">
        <property type="entry name" value="UBCc_UBE2G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000025">
        <property type="entry name" value="ubiquitin-conjugating enzyme E2 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="8">
        <location>
            <begin position="12"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PCH43023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="178" mass="20258" checksum="7B5312773DC767DA" modified="2018-01-31" version="1">MSRSTAPTSTLSNALLLRRQLAELTKRPVDGFSAGLVDDGNFYEWEIMIIGPPDTLYEGGFFRARLSFPEEYPLQPPKMRFITPMWHPNIYPDGNVCISILHPPGEDQYGYEDSGERWLPVHTVESILLSVISLLSSEKPNLDSPANVDAAKEVRENFEAYKKKVRRLVRRSAEEVFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JT17</accession>
    <name>A0A2H3JT17_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">thymidylate synthase</fullName>
            <ecNumber evidence="2">2.1.1.45</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WOLCODRAFT_101426</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>dUMP + (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate = 7,8-dihydrofolate + dTMP</text>
            <dbReference type="Rhea" id="RHEA:12104"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57451"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="2.1.1.45"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; dTTP biosynthesis.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.45" evidence="2"/>
    <dbReference type="EMBL" id="KB468124">
        <property type="protein sequence ID" value="PCH42019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JT17"/>
    <dbReference type="STRING" id="742152.A0A2H3JT17"/>
    <dbReference type="OMA" id="AYGRFWR"/>
    <dbReference type="OrthoDB" id="766at2759"/>
    <dbReference type="UniPathway" id="UPA00575"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004799">
        <property type="term" value="F:thymidylate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006231">
        <property type="term" value="P:dTMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00351">
        <property type="entry name" value="TS_Pyrimidine_HMase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.572.10:FF:000013">
        <property type="entry name" value="Thymidylate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.572.10">
        <property type="entry name" value="Thymidylate synthase/dCMP hydroxymethylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00008">
        <property type="entry name" value="Thymidy_synth_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045097">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023451">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036926">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000398">
        <property type="entry name" value="Thymidylate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020940">
        <property type="entry name" value="Thymidylate_synthase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03284">
        <property type="entry name" value="thym_sym"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11548:SF2">
        <property type="entry name" value="THYMIDYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11548">
        <property type="entry name" value="THYMIDYLATE SYNTHASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00303">
        <property type="entry name" value="Thymidylat_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00108">
        <property type="entry name" value="THYMDSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55831">
        <property type="entry name" value="Thymidylate synthase/dCMP hydroxymethylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00091">
        <property type="entry name" value="THYMIDYLATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylate synthase/dCMP hydroxymethylase" evidence="8">
        <location>
            <begin position="17"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PCH42019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="310" mass="35021" checksum="54670BF7020E6A0C" modified="2018-01-31" version="1">MDTPSTVLSNSRPHDEQQYLSLIRTVLDTGEARPDRTGTGTLSIFAPPALRFSLADSTLPLLTTKRTFLRGILEELLWFIHGSTDSKLLSAKGIKIWDGNGNKAFLEKRGLGHRREGDLGPVYGFQWRHFGAHYTDCEADYSGQGVDQLAECIRKIKEEPMDRRIILSAWNPADIPLMALPPCHVLCQFYVHLPPTSTPDAPRRLSCLLYQRSADLGLGIPFNIASYALLTHLIAHLTHTEPHELIIQLGDAHVYRDHVDALEEQLKREPRPFPKIRWTREVTDVDDFRAEDIVVEGYDPHPSIAMKMSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JTP4</accession>
    <name>A0A2H3JTP4_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">XLF-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WOLCODRAFT_143949</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB468124">
        <property type="protein sequence ID" value="PCH42269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JTP4"/>
    <dbReference type="STRING" id="742152.A0A2H3JTP4"/>
    <dbReference type="OMA" id="TFKWRWE"/>
    <dbReference type="OrthoDB" id="3184250at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd22285">
        <property type="entry name" value="HD_XLF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.210.10">
        <property type="entry name" value="DNA double-strand break repair and VJ recombination XRCC4, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015381">
        <property type="entry name" value="XLF-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038051">
        <property type="entry name" value="XRCC4-like_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09302">
        <property type="entry name" value="XLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XLF-like N-terminal" evidence="6">
        <location>
            <begin position="17"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="243"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="243"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="285"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="305"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="322"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF09302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PCH42269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="371" mass="41770" checksum="AD8F616604023B68" modified="2018-01-31" version="1">MEYFSEEHAKLLIPREWLVKIDSDKSTPYLMKFYGSIEKQLCCAFATDTKNVWGEVLTMEQFVRRWQKSNPQQRTSFSNLKTSQEEEEWRAAILEFISSAHSLGGLPEVSFEIVESHNADLHYELSGENFKWKWEMYHLGPKFSAEILSQHLIVPLISMSHLAFSSTDPVGRMRDEDLERAADRIGRTARRTLDTHLRHAMSKPQVTTTLQRLTALFNFVPRIPPITSEVEVPNFVVPHVPPTSQALSESPEQSSPKRSRPMSLLAEQRTESQSPNVSKLPPSSPCASQQPMTQATDDGSDTEPEEGRTHDKQKRDEKEGGVQQSMTNRTSPPNAGTAAHASQGHSSQPPENDICNAPSEEEAQTQQFAAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JTU7</accession>
    <name>A0A2H3JTU7_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal protein L6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WOLCODRAFT_98345</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468053">
        <property type="protein sequence ID" value="PCH40134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JTU7"/>
    <dbReference type="STRING" id="742152.A0A2H3JTU7"/>
    <dbReference type="OMA" id="RERHGLC"/>
    <dbReference type="OrthoDB" id="540873at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.930.12">
        <property type="entry name" value="Ribosomal protein L6, alpha-beta domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000702">
        <property type="entry name" value="Ribosomal_uL6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036789">
        <property type="entry name" value="Ribosomal_uL6-like_a/b-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020040">
        <property type="entry name" value="Ribosomal_uL6_a/b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019906">
        <property type="entry name" value="Ribosomal_uL6_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002358">
        <property type="entry name" value="Ribosomal_uL6_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03654">
        <property type="entry name" value="L6_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655">
        <property type="entry name" value="60S/50S RIBOSOMAL PROTEIN L6/L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655:SF14">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL6M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00347">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002162">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00059">
        <property type="entry name" value="RIBOSOMALL6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56053">
        <property type="entry name" value="Ribosomal protein L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00525">
        <property type="entry name" value="RIBOSOMAL_L6_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL6 alpha-beta" evidence="5">
        <location>
            <begin position="119"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PCH40134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="214" mass="23422" checksum="296B0A5C794CA9ED" modified="2018-01-31" version="1">MIVRQQIRHAFRSFSSSACSSTAYISNIGKQPIRFPPNVTLTPSPTSLSVNGPLGTTSVPLEPYMHLTFTDPNTVALTVEDASEKKQRSMWGLTRTLISNAVVGMTEGFSVPLYLVGVGYRAAIEPDPRGQGEGRSGQRLNMKLGFSHSVCEAIPEHIKVEVPSATKIVLSCTDKHLLGLFAAKVRKWRPPEPYKGKGIFVGNETVRIKTVKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JUC7</accession>
    <name>A0A2H3JUC7_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_149781</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468053">
        <property type="protein sequence ID" value="PCH39737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JUC7"/>
    <dbReference type="STRING" id="742152.A0A2H3JUC7"/>
    <dbReference type="OrthoDB" id="3263571at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH39737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="248" mass="28439" checksum="082719B3E236EB10" modified="2018-01-31" version="1">MFAADYQSDDQKILFIMSYIRGSDRVNQWKENYYAKYANPITRAFALPPLAQFSAKFDAAFEPIEEKQKTNDDLFDIKQDKKSIDDFNIEFDNLVGKTRLNRQQCDLLFITMYKRAIRPALITHIINIVPPVVTLTEWMKQASINKNNYNTFIRGQGNDKKKPQWRAKAPNASTTATPKDPNVMEVDRMTTEERRKLQCKKKPSKGRTRKAEATEEGTSMAHIEEAEEDTDDDDSDGATAIEEAVNAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JUK4</accession>
    <name>A0A2H3JUK4_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Protein phosphatase methylesterase 1</fullName>
            <shortName evidence="6">PME-1</shortName>
            <ecNumber evidence="6">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WOLCODRAFT_137969</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Demethylates proteins that have been reversibly carboxymethylated.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>[phosphatase 2A protein]-C-terminal L-leucine methyl ester + H2O = [phosphatase 2A protein]-C-terminal L-leucine + methanol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48548"/>
            <dbReference type="Rhea" id="RHEA-COMP:12134"/>
            <dbReference type="Rhea" id="RHEA-COMP:12135"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17790"/>
            <dbReference type="ChEBI" id="CHEBI:90516"/>
            <dbReference type="ChEBI" id="CHEBI:90517"/>
            <dbReference type="EC" id="3.1.1.89"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the AB hydrolase superfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="KB468124">
        <property type="protein sequence ID" value="PCH42579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JUK4"/>
    <dbReference type="STRING" id="742152.A0A2H3JUK4"/>
    <dbReference type="OMA" id="VMVCHHG"/>
    <dbReference type="OrthoDB" id="194865at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051723">
        <property type="term" value="F:protein methylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016812">
        <property type="entry name" value="PPase_methylesterase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14189:SF0">
        <property type="entry name" value="PROTEIN PHOSPHATASE METHYLESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14189">
        <property type="entry name" value="PROTEIN PHOSPHATASE METHYLESTERASE-1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF022950">
        <property type="entry name" value="PPase_methylesterase_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="9">
        <location>
            <begin position="102"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="17"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="215"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR022950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR022950-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PCH42579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="381" mass="41259" checksum="313EE995F99C8B5D" modified="2018-01-31" version="1">MSDLYRSALQARIAKLPMLPPEDGEDDEESELADSIGSLPTGFGPAPMPSRSTRTKRAPNVNFAPISAAGYFEQATQADVSASGLDVRAYYTPPKFADGTVMVFHHGAGQSALTFACVAKEVTEISRGECGVLALDCRGHGKTARTTDTESTQEDFAIETLTTDLVNALKVIYPDPATAPTLLLAGHSLGGSVIVRACPLLQEANYRITGVAVLDIVEEFTLEALPMMNSLLDARPEGFDSQEAAIEWHVRTNAIRNPDSARVSIPAIIKPAPPDSPLSSPAFVWRTPLRSTAPYWTSWFTGLSGKFLAARTARLLVLAGAERLDKELMIGQMQGKFQLVVIPGVGHMLQEDDPTRLAEVLVEFWRRNERVIAGVKKVGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JUS8</accession>
    <name>A0A2H3JUS8_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Hydroxyethylthiazole kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">WOLCODRAFT_138549</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) = thiamine phosphate + CO2 + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:47848"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:62890"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) = thiamine phosphate + CO2 + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:47844"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:62899"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>4-methyl-5-(2-phosphooxyethyl)-thiazole + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + H(+) = thiamine phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22328"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:58296"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-(2-hydroxyethyl)-4-methylthiazole + ATP = 4-methyl-5-(2-phosphooxyethyl)-thiazole + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24212"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17957"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58296"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.50"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-methyl-5-(2-phosphoethyl)-thiazole from 5-(2-hydroxyethyl)-4-methylthiazole: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine phosphate from 4-amino-2-methyl-5-diphosphomethylpyrimidine and 4-methyl-5-(2-phosphoethyl)-thiazole: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="16">In the C-terminal section; belongs to the Thz kinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="17">In the N-terminal section; belongs to the thiamine-phosphate synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468146">
        <property type="protein sequence ID" value="PCH43723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JUS8"/>
    <dbReference type="STRING" id="742152.A0A2H3JUS8"/>
    <dbReference type="OMA" id="GQTDMPI"/>
    <dbReference type="OrthoDB" id="4994at2759"/>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00139"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004417">
        <property type="term" value="F:hydroxyethylthiazole kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004789">
        <property type="term" value="F:thiamine-phosphate diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01170">
        <property type="entry name" value="THZ_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00564">
        <property type="entry name" value="TMP_TenI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000104">
        <property type="entry name" value="Thiamine biosynthetic bifunctional enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00228">
        <property type="entry name" value="Thz_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00097">
        <property type="entry name" value="TMP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000417">
        <property type="entry name" value="Hyethyz_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036206">
        <property type="entry name" value="ThiamineP_synth_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022998">
        <property type="entry name" value="ThiamineP_synth_TenI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034291">
        <property type="entry name" value="TMP_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006830">
        <property type="entry name" value="PRK09355.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00693">
        <property type="entry name" value="thiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20857:SF23">
        <property type="entry name" value="THIAMINE BIOSYNTHETIC BIFUNCTIONAL ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20857">
        <property type="entry name" value="THIAMINE-PHOSPHATE PYROPHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02110">
        <property type="entry name" value="HK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02581">
        <property type="entry name" value="TMP-TENI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01099">
        <property type="entry name" value="HYETHTZKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51391">
        <property type="entry name" value="Thiamin phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 19" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiamine phosphate synthase/TenI" evidence="18">
        <location>
            <begin position="12"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00061146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00061283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PCH43723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="532" mass="55356" checksum="A383BBEBCDD30687" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JUZ2</accession>
    <name>A0A2H3JUZ2_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_70075</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH41668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JUZ2"/>
    <dbReference type="OrthoDB" id="2736594at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH41668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="288" mass="32672" checksum="19ACCD65B24F570A" modified="2018-01-31" version="1">MAAFGFTTSTNHCIISTRDTAASRIPIEIWEYILDVLKDDPHALLACELVCRGWRTRSRYLLDQVDYEPTFCERESVVRWARFMQVIKKHRARVTRVDLAGEHSQEGQPGSLAHLGTFVAMLAGRLPHLRHLYIRDGAWPRGTIHASTVFFHLSTFPSVSKLWLNNITFPSVTIFGRLICSFKRLSELRAHNISFVDTQLPPRGRPWLAPTKLTHIYMDRASSDMLRALTATTVAQKCHELDVSASGEAIRSSALQELLWAARESLHTLSLDLFTSLETSDMRDLVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JV73</accession>
    <name>A0A2H3JV73_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_67942</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468053">
        <property type="protein sequence ID" value="PCH40047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JV73"/>
    <dbReference type="STRING" id="742152.A0A2H3JV73"/>
    <dbReference type="OrthoDB" id="3235313at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH40047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="103" mass="12071" checksum="48AADF91C8CB28B1" modified="2018-01-31" version="1" fragment="single">YRDALPLHNVAEVRTISHENKIHDREPEGMFDEYIAFLRDGTVPTRFLDDDGMRHNFVQRADHFILHDGRLWRKAGTNLPRLVISDKTRRKDLIAQAHNDCGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JVG8</accession>
    <name>A0A2H3JVG8_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Mitochondrial import inner membrane translocase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WOLCODRAFT_116748</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Heterohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
            <topology evidence="1 11">Peripheral membrane protein</topology>
            <orientation evidence="1 11">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the small Tim family.</text>
    </comment>
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        <property type="protein sequence ID" value="PCH40147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JVG8"/>
    <dbReference type="STRING" id="742152.A0A2H3JVG8"/>
    <dbReference type="OMA" id="QDFLRMY"/>
    <dbReference type="OrthoDB" id="1551503at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.810">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim13 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050673">
        <property type="entry name" value="Mito_inner_translocase_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004217">
        <property type="entry name" value="Tim10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13172">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM9B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02953">
        <property type="entry name" value="zf-Tim10_DDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0143">Chaperone</keyword>
    <keyword evidence="10 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Tim10-like" evidence="12">
        <location>
            <begin position="17"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PCH40147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="89" mass="10157" checksum="862905BCDD943B8E" modified="2018-01-31" version="1">MDLSAMNAAEQAHISKVIEKKQMQDFLRMYSNLVERCFNSCCNDFTSKALSSKEEQCVMNCTDKFLKHSERVGARFAEHNADAMNTAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JVS2</accession>
    <name>A0A2H3JVS2_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CASTOR ACT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_24290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH40814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JVS2"/>
    <dbReference type="OrthoDB" id="58529at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2130.10">
        <property type="entry name" value="VC0802-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="245"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH40814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="423" mass="45656" checksum="72907B83952CF76E" modified="2018-01-31" version="1">MSTPSDFSDPSDGPLSHSENAEDVKTPALPSRPVMSRAQSHSPSGCEVSLLTPDLTYVGLSDDNADIWGLKIIKLVSFPELIVGSIARTRTSTSSSQLFSAAPPGHRETAITAEEFVSTVDTQLQELSLNISAVSEGEGGTTSGSDTTTRVGPESPKDPELENVDSPVHDIHLDQLWHDDTDNASPDTGNTSEEDGSLAAASPRRHYSNDFPAVNILPHDYDSKRDRSYSEPTTGRPPLAHYDTFDTFTTVDTVRPSRSRDASKSGSQSRSASASSATSSSAGIPSAPPLVPFFSFTRTPEGSSLTAPVSLLAALFPPDERDMVICRAELDVLDSREASPTADDEDVDEHEDEVDDDEPQGPLRCLQIDLRKFGLDKHGLVNRFSRTLEENGINHMYNSTYKTANLLVDKAHATRAQALLRSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JWF7</accession>
    <name>A0A2H3JWF7_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GAR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WOLCODRAFT_104909</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB468157">
        <property type="protein sequence ID" value="PCH44313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JWF7"/>
    <dbReference type="STRING" id="742152.A0A2H3JWF7"/>
    <dbReference type="OMA" id="SKKVMCR"/>
    <dbReference type="OrthoDB" id="5559380at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
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</entry>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
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                <person name="Larrondo L.F."/>
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                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
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                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
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                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
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            <strain evidence="1 2">MD-104</strain>
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        </source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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    <name>A0A2H3JYP0_WOLCO</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
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            <authorList>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-isoleucine + 2-oxoglutarate = (S)-3-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:18321"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-valine + 2-oxoglutarate = 3-methyl-2-oxobutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24813"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.42" evidence="10"/>
    <dbReference type="EMBL" id="KB468135">
        <property type="protein sequence ID" value="PCH42998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JYP0"/>
    <dbReference type="STRING" id="742152.A0A2H3JYP0"/>
    <dbReference type="OMA" id="HMVTCRW"/>
    <dbReference type="OrthoDB" id="1732691at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004084">
        <property type="term" value="F:branched-chain-amino-acid transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018300">
        <property type="entry name" value="Aminotrans_IV_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005786">
        <property type="entry name" value="B_amino_transII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825:SF44">
        <property type="entry name" value="BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825">
        <property type="entry name" value="SUBGROUP IIII AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00770">
        <property type="entry name" value="AA_TRANSFER_CLASS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 10 11" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7 10" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="6 9" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10 11" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PCH42998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="303" mass="33604" checksum="096EDAA3B2D01301" modified="2018-01-31" version="1">MFPGEHGGQTIDQITYVQSKPAPSAHLPDLDISKLIITPAASLKSVPPPETLKFGQTMTDHMLYATYHPETGCTNVFEGFRAYMGPDGKIRLFRQNMNVARLKRSVDRIALPPGGTGAYKLSLNYGPTLKPQQLAEQQGYNQTLWLLDETVTEAGAMNFFVVVKRGDGDWDVTTAPLDGTVLAGVTRDSCLALASAHQSCTVLPYVPENLRLHAHEQHLTMSDLTRWNPEGRLLEAFMVGTAVVVNGVGRIGYMDQDIILQEHEGGRGPVAHALFERILDIQEGRFEFEGWGYPLMTRKRRNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K0J7</accession>
    <name>A0A2H3K0J7_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fork-head domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WOLCODRAFT_163856</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB468124">
        <property type="protein sequence ID" value="PCH42524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K0J7"/>
    <dbReference type="STRING" id="742152.A0A2H3K0J7"/>
    <dbReference type="OMA" id="ATDDNID"/>
    <dbReference type="OrthoDB" id="5954824at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00059">
        <property type="entry name" value="FH_FOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050211">
        <property type="entry name" value="FOX_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829:SF343">
        <property type="entry name" value="FORK-HEAD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829">
        <property type="entry name" value="FORKHEAD BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fork-head" evidence="5">
        <location>
            <begin position="360"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="3">
        <location>
            <begin position="360"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="127"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="440"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="599"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="68"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="131"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="143"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="485"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="620"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="712"/>
            <end position="726"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PCH42524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="726" mass="77974" checksum="8B5607881AC636C8" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K0R7</accession>
    <name>A0A2H3K0R7_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ras-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WOLCODRAFT_25459</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB468124">
        <property type="protein sequence ID" value="PCH42604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K0R7"/>
    <dbReference type="STRING" id="742152.A0A2H3K0R7"/>
    <dbReference type="OMA" id="EYKLVVM"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00876">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001763">
        <property type="entry name" value="Ras family gtpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PCH42604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="187" mass="21608" checksum="45D981AF26A4C5C8" modified="2018-01-31" version="1">MAPLRKYHAVVLGAGGVGKSALTIRFGRNEFIEQYNPTIEEEYRCDLIVDGERCILEILDTPGTEQFTALNERYLQQGAGFLLVFSLIDENSLRDIDSIRQQIFQVKGADMDIPIVVVGTKLDLNTEREVSRARIQELAKQWNLPFYETSAKRNWHVSEVFEDLVRQMRKCYPRDEHGRKKDPCILM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K0V4</accession>
    <name>A0A2H3K0V4_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytosine-purine permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WOLCODRAFT_77470</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468168">
        <property type="protein sequence ID" value="PCH44809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K0V4"/>
    <dbReference type="STRING" id="742152.A0A2H3K0V4"/>
    <dbReference type="OMA" id="RNDWERY"/>
    <dbReference type="OrthoDB" id="2116389at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026030">
        <property type="entry name" value="Pur-cyt_permease_Fcy2/21/22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806:SF5">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002744">
        <property type="entry name" value="Pur-cyt_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="74"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="146"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="277"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="330"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="373"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="401"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="442"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="472"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR002744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PCH44809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="508" mass="55131" checksum="C426E58ED3FAA1AD" modified="2018-01-31" version="1">MSNTEQLECSPFTELEALDKQDPELDHEIASPAPAEQSLLDRATSLLIRYGVETNGIDPISPSERTDKRLYQMFFVWFSTNMNVIAFGGAASGPAFYGIGLRDCLIILLIVDFVACIIPAYFAVFGPKLGMRSMVQARYTWGYYGAMLPSALNVFSMQGFLIISCIIGGQLLASVSGGLLNDTLGIVIISLISLVVTFFGYRVIHWYESVAWIPNVILFILMLGVGGKHLAIVPTSPSSASTIITYSTTMASSAISWCTMTSDYGVYHDAKASSLRIFSYTFAGFFFSTFIANALGVAFAASAVSVPLWAAGFDNGNSVGGLVAAVMSPLATFGKIVVVLVSLSVPSMCAPTMYTFSSSLMTISQRFAQIPRYIFVFVSVAILIPVAIEGALRYYNTFTDVINIIGYWSVVHGALILMEHAVFRKCDYAAYVLEDWNNPKRLPLGIAATATFLCAFGIIIPCMNQAWYVGPIAAAGSGDIGIIAGSCAVCILYPVFRRIEKRFARQRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K1C5</accession>
    <name>A0A2H3K1C5_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Palmitoyl-protein thioesterase 1</fullName>
            <ecNumber evidence="2">3.1.2.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Palmitoyl-protein hydrolase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WOLCODRAFT_138677</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the palmitoyl-protein thioesterase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.22" evidence="2"/>
    <dbReference type="EMBL" id="KB468146">
        <property type="protein sequence ID" value="PCH43918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K1C5"/>
    <dbReference type="STRING" id="742152.A0A2H3K1C5"/>
    <dbReference type="OMA" id="KFVMVMF"/>
    <dbReference type="OrthoDB" id="10263094at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000107">
        <property type="entry name" value="Palmitoyl-protein thioesterase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002472">
        <property type="entry name" value="Palm_thioest"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11247:SF8">
        <property type="entry name" value="PALMITOYL-PROTEIN THIOESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11247">
        <property type="entry name" value="PALMITOYL-PROTEIN THIOESTERASE/DOLICHYLDIPHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02089">
        <property type="entry name" value="Palm_thioest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00414">
        <property type="entry name" value="PPTHIESTRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013931016" description="Palmitoyl-protein thioesterase 1" evidence="9">
        <location>
            <begin position="21"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PCH43918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="333" mass="36358" checksum="51D16A7F185F7B4E" modified="2018-01-31" version="1">MLISLFLALGALLVQPLCTASPLNGPTSQTPLHVSASQPRPLVIWHGLGDSYGSPGILEFVSMVKDMHPGIFVHSVYLDKNLEEDQRATFYGNVNEQVERVSAQLANITELQGGFDAMGFSQGGQFLRAYVERSNSPPVHNLVTFGSQHMGISDIPGCRPWDLLCQAARRAAQGGVYTQYAQEHLVQAQYYRDPARLETYLASNRFLADINNEAPGAPNATYAANLATLNTLVLVLFLQDKTVVPKESSWFGSYAVPEPEPASASAAAKTIVPMRLQPLYLGDWIGLRTLDERGAVVLETCPGEHMQLSNDCWQPLARRFVGGLVDDATFVVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K282</accession>
    <name>A0A2H3K282_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_26580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468157">
        <property type="protein sequence ID" value="PCH44248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K282"/>
    <dbReference type="OrthoDB" id="2756573at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH44248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="148" mass="16692" checksum="C203666C692DD294" modified="2018-01-31" version="1">MIATLSAVYCARAGRIISDVVLLCVTWNNLVKLARCGDTVDRRIISLSKLLLKDGTGYFLFLLVLNVLQIVLWKTGTFFLLTMWATPLSAITLSRFLLDLRLCSVSSQTPLSEWQTDSGTSYSQHQDDTVYLSTFINTMDTNVQYEPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K2J0</accession>
    <name>A0A2H3K2J0_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_153318</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468135">
        <property type="protein sequence ID" value="PCH43264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K2J0"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH43264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="269" mass="29824" checksum="62D94B88785C3AF6" modified="2018-01-31" version="1">MDYLGYAISGSDGILSLSPETTNGTDACGLDLTVSPGEVYYFHTNGPAALVDPHVFTTVSSHSSSCDSDFRPTLIQRDEICIFTNAETTIRSLKSSDVAGAANAEPDTYCLTIQSFAKEPLAKAYDGLDARLRSPLPDHWPPEVILTAIYAGAAIEAWGPLGTSELLRNTTDNLYYPDGYYKRGTDNDGAERERGWQRRKEAQDKQTTDRREACEQRRGLHDTEFDALDVVAFLWDLNNRPALERAKRIAEAEAKQRSAEKVTEWLNGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K3F2</accession>
    <name>A0A2H3K3F2_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WOLCODRAFT_90362</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
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                <person name="Spatafora J.W."/>
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                <person name="Benoit I."/>
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                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>tRNA(Tyr) + L-tyrosine + ATP = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10220"/>
            <dbReference type="Rhea" id="RHEA-COMP:9706"/>
            <dbReference type="Rhea" id="RHEA-COMP:9707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78536"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.1" evidence="1 11"/>
    <dbReference type="EMBL" id="KB468146">
        <property type="protein sequence ID" value="PCH43644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K3M7"/>
    <dbReference type="STRING" id="742152.A0A2H3K3M7"/>
    <dbReference type="OMA" id="YMMAKDS"/>
    <dbReference type="OrthoDB" id="1666796at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004831">
        <property type="term" value="F:tyrosine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006437">
        <property type="term" value="P:tyrosyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00805">
        <property type="entry name" value="TyrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.240.10:FF:000001">
        <property type="entry name" value="Tyrosine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02006">
        <property type="entry name" value="Tyr_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054608">
        <property type="entry name" value="SYY-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002307">
        <property type="entry name" value="Tyr-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024088">
        <property type="entry name" value="Tyr-tRNA-ligase_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024107">
        <property type="entry name" value="Tyr-tRNA-ligase_bac_1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00234">
        <property type="entry name" value="tyrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11766:SF0">
        <property type="entry name" value="TYROSINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11766">
        <property type="entry name" value="TYROSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22421">
        <property type="entry name" value="SYY_C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01040">
        <property type="entry name" value="TRNASYNTHTYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55174">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Tyrosine--tRNA ligase SYY-like C-terminal" evidence="12">
        <location>
            <begin position="409"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF22421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PCH43644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="478" mass="52002" checksum="D5D52F2DB2F7EDB8" modified="2018-01-31" version="1">MLACRNALRHARTTNHATRRRLHVQVDLLDDLKSRGLVSDITRPDILHAEIKRGRQVVYAGVDPTASYLHVGHLLPLLCLLHFQIRGHHIIPLIGGATGLIGDPSGRSTERPLSEASVVERNVKALTGAVHSFFQSALSYARTRFPVSDTPILEPDVRNNLEWLQGLGLLEFLRTVGVHSRVNAMLARESVRARLASQQGISFTEFTYQLLQSYDFLTLHRRAGCTIQIGGSDQWGNIVAGIDLINRTAAGAGPISDAAPETVEKGFGIVTPLLTTASGEKFGKSAGNAIALDERVTSVFDFYQFFVRTPDADVGRYLQMFTLLPLERVDEVMKTHADAPEKRIAQRLLASEVTELVHGKDGLQRALTATAVLYDNDLTSTPAEALIASLRGLPLFHSIPSSDLFALTVPQLAARFKLASSNGAARQLVAAQGLYVNNQPVSAPQQRLTTADLLDGRLVILRAGKQKQAVIAVSDTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3ISM9</accession>
    <name>A0A2H3ISM9_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_147101</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH32992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3ISM9"/>
    <dbReference type="STRING" id="742152.A0A2H3ISM9"/>
    <dbReference type="OrthoDB" id="74360at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH32992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="137" mass="14655" checksum="7373B618DAC92D68" modified="2018-01-31" version="1" fragment="single">MTAAAAPLAPTAAPALDKVSLPNLSQTAAPGDDLKPTLPTLDRLGASLQPDVDVQKVASEFFRTFAQHVSANNVEGITSLFLEDGWWRDQLALTWEFRTFHGVGKIRKFLADQLAGSGIALGGVRDVALQQPYPDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3ITI1</accession>
    <name>A0A2H3ITI1_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7702 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_135033</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH33292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3ITI1"/>
    <dbReference type="STRING" id="742152.A0A2H3ITI1"/>
    <dbReference type="OMA" id="MQVIMEW"/>
    <dbReference type="OrthoDB" id="2560628at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056119">
        <property type="entry name" value="DUF7702"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42109:SF2">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42109">
        <property type="entry name" value="UNPLACED GENOMIC SCAFFOLD UM_SCAF_CONTIG_1.265, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24800">
        <property type="entry name" value="DUF7702"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7702" evidence="2">
        <location>
            <begin position="1"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH33292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="262" mass="28887" checksum="931901570EA54C56" modified="2018-01-31" version="1">MRHGFQRQAGWIFLCILSILRIVGGITHVMYEHDTSNSNLEITYEICEASGVSPLLLATLGFLRTICQSTLESHLVTRALQIMGILGTVALILSIVGGVQESSAKTESALTSAASTRHIGAILFVVLFALIVLLHVLCWANKSRIAPYRRMLLKGISCALPFVCVRVLYSILASYAPLPETINADGSVSYAPSNSPLERFSYYNGSWIIYLVMSVLMEFITVVIYITVGLKTPLQREPVDTMPPQTWSQGYDDSNVMLNPRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IUA4</accession>
    <name>A0A2H3IUA4_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-dependent RNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_112049</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RdRP family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.48" evidence="1"/>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH33560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3IUA4"/>
    <dbReference type="STRING" id="742152.A0A2H3IUA4"/>
    <dbReference type="OMA" id="PITHHEP"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031380">
        <property type="term" value="C:nuclear RNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007855">
        <property type="entry name" value="RDRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057596">
        <property type="entry name" value="RDRP_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079">
        <property type="entry name" value="RNA-DEPENDENT RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079:SF55">
        <property type="entry name" value="RNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05183">
        <property type="entry name" value="RdRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0696">RNA-directed RNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RDRP core" evidence="2">
        <location>
            <begin position="413"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH33560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="1178" mass="134198" checksum="7CB005963076047A" modified="2018-01-31" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IVB0</accession>
    <name>A0A2H3IVB0_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">isopentenyl-diphosphate Delta-isomerase</fullName>
            <ecNumber evidence="4">5.3.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">WOLCODRAFT_22155</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>isopentenyl diphosphate = dimethylallyl diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23284"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="EC" id="5.3.3.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:23285"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from isopentenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the IPP isomerase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="5.3.3.2" evidence="4"/>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH33661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3IVB0"/>
    <dbReference type="SMR" id="A0A2H3IVB0"/>
    <dbReference type="STRING" id="742152.A0A2H3IVB0"/>
    <dbReference type="OMA" id="KAPFDNG"/>
    <dbReference type="OrthoDB" id="510307at2759"/>
    <dbReference type="UniPathway" id="UPA00059">
        <property type="reaction ID" value="UER00104"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004452">
        <property type="term" value="F:isopentenyl-diphosphate delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050992">
        <property type="term" value="P:dimethylallyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009240">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006694">
        <property type="term" value="P:steroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02885">
        <property type="entry name" value="NUDIX_IPP_Isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000012">
        <property type="entry name" value="Isopentenyl-diphosphate Delta-isomerase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011876">
        <property type="entry name" value="IsopentenylPP_isomerase_typ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02150">
        <property type="entry name" value="IPP_isom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10885">
        <property type="entry name" value="ISOPENTENYL-DIPHOSPHATE DELTA-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10885:SF0">
        <property type="entry name" value="ISOPENTENYL-DIPHOSPHATE DELTA-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018427">
        <property type="entry name" value="Isopntndiph_ism"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0752">Steroid biosynthesis</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="13">
        <location>
            <begin position="61"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PCH33661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="251" mass="28595" checksum="1376BF087BF0F01D" modified="2018-01-31" version="1">MSSPAVEASRAVLSTIDLSKYDAEQSRLMDERCILVDEEDRALGAADKKTCHLMENINKGLLHRAFSAFVFRPNDGKLLLQQRASEKITFPDMWTNTCCSHPLDDFEQEKVEKDQLGVKVAASRKLEHELGIPQSQTPIDQFQYLTRIHYLAPSNGIWGEHAVDYILFLTADVTVKPNLNEIRDYKYVDKAELQSLFDDPANTFTPWFKLIARDFLFGWWDELLNRKDANGKINAQSLNGLVDGSKVVKMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IVQ7</accession>
    <name>A0A2H3IVQ7_WOLCO</name>
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        <recommendedName>
            <fullName evidence="9">Nucleoporin Pom152</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WOLCODRAFT_130155</name>
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    <organism evidence="7 8">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD-104</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="PCH34046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OMA" id="DRSNCKR"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Ig-like_POM152"/>
    </dbReference>
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        <property type="entry name" value="Ig-like_POM152_1st"/>
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    <dbReference type="InterPro" id="IPR056544">
        <property type="entry name" value="Ig_POM152"/>
    </dbReference>
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        <property type="entry name" value="Pom152"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056540">
        <property type="entry name" value="TMD_POM152"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28206">
        <property type="entry name" value="NUCLEOPORIN POM152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28206:SF1">
        <property type="entry name" value="NUCLEOPORIN POM152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24312">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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            <begin position="27"/>
            <end position="113"/>
        </location>
    </feature>
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    </feature>
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    </feature>
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        </location>
    </feature>
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            <end position="1204"/>
        </location>
    </feature>
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        <location>
            <begin position="254"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF23664"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF24097"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF24312"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF24519"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF24527"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH34046.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1311" mass="144437" checksum="9B1BBBF1C5175119" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IW09</accession>
    <name>A0A2H3IW09_WOLCO</name>
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        <submittedName>
            <fullName evidence="10">Purine-cytosine permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WOLCODRAFT_135525</name>
    </gene>
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        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD-104</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015851">
        <property type="term" value="P:nucleobase transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Pur-cyt_permease_Fcy2/21/22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806:SF1">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
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            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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            <begin position="150"/>
            <end position="171"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
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            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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            <end position="233"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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            <end position="275"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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            <end position="310"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="9">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
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            <end position="424"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="453"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="489"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR002744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
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                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
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                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
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                <person name="Martin R."/>
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                <person name="Morgenstern I."/>
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                <person name="Nagy L.G."/>
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                <person name="Ohm R.A."/>
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                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
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                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
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            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH34752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="352" mass="39737" checksum="4BE338F4AC710784" modified="2018-01-31" version="1">MEAWKAGYVGYGALRLIKTVKDIASNINGPYSNTMPIIQSSGTGKSRMVDEMAKSIFTLPFKLAPTGVDGATYPASDAAIREYLCHANKYTERDFVIARYLVFFASLLSVVAEEVNHIWGDSPRVLPSEWRAHLETDDKRASLYRRAVEGVPAIWQEVDERAPAKITGLFLSTTSFVAKYAPTYENMPSDRAQAEALQPPYTELPFDCHPNFFPVRGNQYTVDALSTPKFQANFGRPLFWTRYRYGNRTIKEGIVHFARESCFATELAVLDMRIMLDFGPHRDANTVQQCLIESHMRIAVSVPAHREYSYSAYPSEPLLAEAAARIMATIREEQNDDDDNIARTLQNTRRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="2">Uncharacterized protein</fullName>
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        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
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            <taxon>Phaeolaceae</taxon>
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    </organism>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467831">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OMA" id="REFAHHK"/>
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    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH34335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="124" mass="13431" checksum="6961F814146237ED" modified="2018-01-31" version="1">MTDTVVQHPPAIKVGGRRLSVSSRPKPHPATEAKPASPTTEPVDYPRPAPPGEQSPHENHEEEVPKKEKKKGNGGEEHERRLQESLHRKAEQNRPSKDGHTAKNWNAIGGGGRIGQPAGRGLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IYN9</accession>
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        <lineage>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467832">
        <property type="protein sequence ID" value="PCH34545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OMA" id="DANDAWI"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="MAGE homology domain, winged helix WH1 motif"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MHD_dom"/>
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    <dbReference type="PANTHER" id="PTHR11736">
        <property type="entry name" value="MELANOMA-ASSOCIATED ANTIGEN MAGE ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11736:SF14">
        <property type="entry name" value="NSE3 HOMOLOG, SMC5-SMC6 COMPLEX COMPONENT"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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            <end position="79"/>
        </location>
    </feature>
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        <location>
            <begin position="244"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH34545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="349" mass="37533" checksum="1D6DCC754FFFD8F3" modified="2018-01-31" version="1">MSGGDNDEEVDGGEGQTELERKANDLVRLALFTENRRVPLRRDEISKKILGSSTRQFNAVMQRGQEILHKTFGMELVELQRAAGDNLDDQDAELLKGANGKKRAIPTGTKSYILRSILHPKIISIASTPDPEILQIEKADLVQFAETHHTSDHGEDTGPGVSGCILGWSQADEVGSVGLLYTILALILVDGRTMRDSDLRTHLKHLSVGPSSPLPLTSRTTSAQSLTLDSYLASLVRQGYLEKAHGGSSASNKRGRGRPAAHSQATGEDGANAVEWRWGLRAASEVGEQSVAQFVAEFMVNVGAGGEAGSDEEGAASARWREEGRKRQFDAVMKGIERAAAGAALQDLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-05-03" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IZS8</accession>
    <name>A0A2H3IZS8_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH33043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3IZS8"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH33043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="118" mass="12653" checksum="1B14440C0A72F13C" modified="2018-01-31" version="1">MLNRLHALCVTHAHQDQEAVRHRSAPSRSPAAPCSAKTMDDARQTVHPAPCLVCGCGSARFVARSRRACGHCDTCMHATRGPQLEPRAGQGSGVWGAAQARPGLMRPRLVLRAPRRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J0S4</accession>
    <name>A0A2H3J0S4_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">WOLCODRAFT_80792</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MD-104</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467854">
        <property type="protein sequence ID" value="PCH35786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J0S4"/>
    <dbReference type="STRING" id="742152.A0A2H3J0S4"/>
    <dbReference type="OMA" id="MNDELCK"/>
    <dbReference type="OrthoDB" id="1844152at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206:SF5">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12 13" id="KW-0349">Heme</keyword>
    <keyword evidence="9 12 13" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="434"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PCH35786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="493" mass="55569" checksum="12EDBD3421C5CF8F" modified="2018-01-31" version="1">MDYYAHTVQIALFALLVALILRRRWDSIHSIPTIGYSLPLLSYHSAFKFLRNARQSVEEGYARHKVFKIATLDRWMVFVCGPEMNDELCKLPEDVASFEEAVQEWIYAEYSFGAPEYNLTIPAIHGLLVRNLPDVIPHVVDEIGLVFEELFPQEYWVELTNLPNFMSNLAARIVNRVFVGAPICREPEYLRTVTTYATDVIKTKVILDLIPKPLKPLIGNMLPWRARATRLLKHYLSADIADRQMRLDESSCKDKPDDFLMWLAKAARDSGGSMESILTSILMVNFAAIHTSSVTVTSTLFQIASQPEYIAILREDILDAIKAEGWTRGSVNSMGKLDSFIKETQRWQGSGIGTLPSQVLKTVTFSDGTIVPAGVHVHAAQAATYRDSTVYEDADTFKPFRFSEKREQTGQSTRHQFVSTSPEYLIFGHGKHACPGRFFAAIVIKIFLAHLLLRYDVKMGGDGSLPENVTIGTSTILSSKAKVLFRRRQFAHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J1L7</accession>
    <name>A0A2H3J1L7_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">WOLCODRAFT_107550</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB467854">
        <property type="protein sequence ID" value="PCH35585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="742152.A0A2H3J1L7"/>
    <dbReference type="OMA" id="CHIRPKE"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18596">
        <property type="entry name" value="ABC_6TM_VMR1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18604">
        <property type="entry name" value="ABC_6TM_VMR1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000838">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000013">
        <property type="entry name" value="ABC transporter C family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF356">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER ABC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
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    </dbReference>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
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                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
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                <person name="Kuo A."/>
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                <person name="Ling A."/>
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                <person name="Morgenstern I."/>
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    </evidence>
    <sequence length="370" mass="41906" checksum="F5BEE4F53E6264EA" modified="2018-01-31" version="1">MSEELLLNHYLAYRAGRSFVFSNYTWSDSRAQYTYFDGKPIPSRIPLSVLIDGPTAGMPFVSDPHAPTAIGKEYWDEICPHPRVIRNDDVVAPLGQEPTAEALIERWTEVLQGTADPCVEVAQDSAAIFDYLLFGDPKRLLDAWPAFSQSPVLREFRWSPLIELAFDVNRETVSPSRALEPFMSRTPDVHSTMAERYSVLPGLLALHIRRGDYSHHCKHLVKHSSTYTGYSSFPSLPDKFVPPNGDHKTREKEYWRHCLPDIEQIVRRVAEVRRTPAGQSLRSVYVMTNGPAEWVEELKDALYGMGRWTSVASSRDLVVNAEQQYVKQAVDMLIGQRAQVFIGNGFSSLTGQVVMLRMASGIDPETNRFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J462</accession>
    <name>A0A2H3J462_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_127992</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467909">
        <property type="protein sequence ID" value="PCH37030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J462"/>
    <dbReference type="OMA" id="HHNVHVI"/>
    <dbReference type="OrthoDB" id="9876299at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052184">
        <property type="entry name" value="SDR_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458:SF3">
        <property type="entry name" value="CHAIN DEHYDROGENASE (ATSC), PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE SDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH37030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="263" mass="28219" checksum="E4AAED50AC81DFD9" modified="2018-01-31" version="1">MPSYVVVGASRGIGLELVRQLTTSADNTVYAIVRSAADCPYLSALITGLSRDNGRVHVVEGDVADPRAMRAAAARVAALTSGVDVLIHNAARMDRESLYLALDDYDNDDALDADFIEAFKVNVLGAVHAINSFLPLLRQGATKKIVVMSMGGAERDVVWRTRLAGMCAYGVSKAGTNMVATKYSVQLEREGFTVVTVSPGMVDTSATTAREPSEFSKQKRNEVVQGIRKVVPGYMAHTPEEAVQNILKIIAQVGPADNGSFRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J4F4</accession>
    <name>A0A2H3J4F4_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ricin B lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_19493</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467832">
        <property type="protein sequence ID" value="PCH34663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J4F4"/>
    <dbReference type="STRING" id="742152.A0A2H3J4F4"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14200">
        <property type="entry name" value="RicinB_lectin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ricin B lectin" evidence="1">
        <location>
            <begin position="4"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH34663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="180" mass="20953" checksum="0FAB5726DACF666F" modified="2018-01-31" version="1">MVLETGQYIIQNVRSQNFLSMPDSADRSPVVATGDAKDDSCKWNIIKLGNGKYTIENKAQGEYVGYGLTKQFDIKETRKKDQYTRGHLYDFPQEYNNSREQFDVYRSAQSLDFHPDQKLIILMSAMFKRKGRDWQSQDVCSIHETYTIDFAMIDVTSLWRHLLVSQVDSYGNWGRNNKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J5L0</accession>
    <name>A0A2H3J5L0_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_29004</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467920">
        <property type="protein sequence ID" value="PCH37241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J5L0"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH37241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="71" mass="8416" checksum="954AF12BF3152F37" modified="2018-01-31" version="1">MLYFRRGSLAAFQRNRIQSFAGRHPPAPLFQREPARRNVQYLAPGPPRWPEMREQYAEVLRHRIDQPLTGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J6J6</accession>
    <name>A0A2H3J6J6_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_48506</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH33278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J6J6"/>
    <dbReference type="OMA" id="ILIMHAH"/>
    <dbReference type="OrthoDB" id="3249394at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH33278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="101" mass="11447" checksum="05FC87C1F0784460" modified="2018-01-31" version="1" fragment="single">LDYLTANTDGIDLAATIQGCYMEDGFFSNVTTSPKQFKNFREADGLLFICEQEHNLLCIPNILAGKRAVREILIMHAHSLLAHLGAYKTLGLLRDHVWWRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J743</accession>
    <name>A0A2H3J743_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Translocation protein sec66</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_15638</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH38082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J743"/>
    <dbReference type="STRING" id="742152.A0A2H3J743"/>
    <dbReference type="OMA" id="KPWFPAH"/>
    <dbReference type="OrthoDB" id="73168at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031207">
        <property type="term" value="C:Sec62/Sec63 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031204">
        <property type="term" value="P:post-translational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018624">
        <property type="entry name" value="Sec66"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28229">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28229:SF1">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09802">
        <property type="entry name" value="Sec66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH38082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="243" mass="26717" checksum="32F3E94CD19ED003" modified="2018-01-31" version="1">MASVLVPVLYVFIVFGSLFIFSSFYRRRNANKVYEPYFPRHRERDLYVTLLQRTDPPAPESLLKAALVRRAMTDVSRIIRLREDKPALQVLLQKGSIGDDLWNSLLAAEKELEAEILEVVAEANTFVEGWGQIIFQTATEMMHNERMRQTLEQIPAMRQANSRKYGRVTAIPADPNAKPAVTSPSASAPNTPQKPPAPSLPEVLGSDKPNNGSTALSAGAESVLSDGEGSTSPNSPRTPSKSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J7Y8</accession>
    <name>A0A2H3J7Y8_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WOLCODRAFT_64561</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH38061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J7Y8"/>
    <dbReference type="STRING" id="742152.A0A2H3J7Y8"/>
    <dbReference type="OMA" id="TIVTWWL"/>
    <dbReference type="OrthoDB" id="648285at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF74">
        <property type="entry name" value="SUGAR TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G02010)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="166"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="203"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="287"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="320"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="352"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="391"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="426"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="455"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="26"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="501"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="501"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="532"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467943">
        <property type="protein sequence ID" value="PCH38872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J9E0"/>
    <dbReference type="STRING" id="742152.A0A2H3J9E0"/>
    <dbReference type="OMA" id="VMLCHPK"/>
    <dbReference type="OrthoDB" id="3265205at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000654">
        <property type="entry name" value="Integrin-linked_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH38872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="238" mass="26853" checksum="E0838E4DEC18C9DB" modified="2018-01-31" version="1">MTYQNVCREVIVWKHLRHTNIVPLLGVSDIDGARYMISEWMTNGSVRDYANEQEASNKRRWELILDTVAGMEYLHSKEVIHGDLKSSNVLVNNGGRACITDFGLNAVKYNIRSINVATDIPGTGYYGTIQWMPPEYFDPDTAGITHPVQEGDIYSLAGVIWEIFTGEQPFFGVRNATVLSLRLLGEHPQRPSEHSAHGMSDRAWEILTRCWSTDRANRPAAYDLLADLRAEFQAQAPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J9M7</accession>
    <name>A0A2H3J9M7_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA replication licensing factor MCM5</fullName>
            <ecNumber evidence="12">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">WOLCODRAFT_93371</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 17">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the MCM2-7 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="12"/>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH33364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J9M7"/>
    <dbReference type="STRING" id="742152.A0A2H3J9M7"/>
    <dbReference type="OMA" id="ITYCKTR"/>
    <dbReference type="OrthoDB" id="10036721at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17756">
        <property type="entry name" value="MCM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000241">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008048">
        <property type="entry name" value="MCM5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054125">
        <property type="entry name" value="MCM5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF42">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21933">
        <property type="entry name" value="MCM5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01661">
        <property type="entry name" value="MCMPROTEIN5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="13">
        <location>
            <begin position="349"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU368063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PCH33364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="759" mass="83877" checksum="D7F5D83E89F3D617" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JB20</accession>
    <name>A0A2H3JB20_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_133646</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF4">
        <property type="entry name" value="NAD(P)-LINKED OXIDOREDUCTASE SUPERFAMILY PROTEIN"/>
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    </dbReference>
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        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Aldo_ket_red"/>
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    </dbReference>
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        <location>
            <begin position="22"/>
            <end position="315"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH34868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="326" mass="36843" checksum="76A80CA30F3E88AB" modified="2018-01-31" version="1">MSLVKRTMSYVRVGKSGLKVSKIILGCMQYGSTGWIKWAIDNQEEVNKHVKFAYDHGVQTFDTADMYSNGLSEEMLGKAIKTLHLPREELVIMTKVFGAIAPEYDMNLMQADVTPEEIGLVNQHGLGRKHIFDSVKRSLQRLQVDYIDVLFCHRFDYDTPIEETMRALHDMVTAGYVRYIGMSSCYAYQYYAITNKLTPFIVMENQYSLAYREEEREMFPTLQMFGVGAVTWAPLYRGVLGRPLSGQTTRGQVDQVEELANKKGASMAQISIAWILCKEGVAAPIVGATSLKNLEDIIGAVNIELTRDEIKYLEEPYVPLPIDGHV</sequence>
</entry>
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    <accession>A0A2H3JB56</accession>
    <name>A0A2H3JB56_WOLCO</name>
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        <recommendedName>
            <fullName evidence="4">GDP/GTP exchange factor Sec2 N-terminal domain-containing protein</fullName>
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    </protein>
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    <organism evidence="5 6">
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD-104</strain>
        </source>
    </reference>
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        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:Golgi to plasma membrane transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:exocytosis"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR009449">
        <property type="entry name" value="Sec2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14430">
        <property type="entry name" value="RABIN3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14430:SF0">
        <property type="entry name" value="SEC2P DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06428">
        <property type="entry name" value="Sec2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144284">
        <property type="entry name" value="Sec2 N-terminal region"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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            <begin position="234"/>
            <end position="319"/>
        </location>
    </feature>
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        </location>
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        </location>
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            <end position="211"/>
        </location>
    </feature>
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        <location>
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            <end position="452"/>
        </location>
    </feature>
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        <location>
            <begin position="236"/>
            <end position="327"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
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            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="135"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="360"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF06428"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH35979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
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        </source>
    </evidence>
    <sequence length="485" mass="52539" checksum="1F30DD241F4AF8F7" modified="2018-01-31" version="1">MPPRLSTDRGLPRRVDSLHSSKGPYFSDVDEELRDIKRVHTQGQEEDLRLALSRMMSRVEELTSMLKEAFKAQTDLQTELTLAKSNLQLALANNEMLEDALRRDGGVHKDIGWRRWSERERKEREAEEDRRRSSDSAASSAAALNSPVPQPSPMPPLPSSPPPSTTAVPSPAPAPSSEGRFFKFRIGSSSAVNKQFPAPSPRLASTSVSGTKSPMVNGQVLASHLTSASLPSLVPARDWGKEIEELTAELKKERDAKKSVAAQKDALEAELESLSQALFEEANKMVSTERRKLAETEDELKELQAEREALRNALRLLERQSRAAGNELSSIEEGVVSGHAYTLSESSARAIKSPPPSRPLSPSSQPLSPSSGDDGLSSANTVVASQAHRPPPLAILDPDADELSASPTPDEDLQEHVTPDSSQAALQDKESPAESAQPSPSPPPSPSLRSPEIGEYVYPLMRRLPMELLAGEASPWADAVSSSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
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        <recommendedName>
            <fullName evidence="6">RanBP2-type domain-containing protein</fullName>
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    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467920">
        <property type="protein sequence ID" value="PCH37293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="742152.A0A2H3JBV1"/>
    <dbReference type="OrthoDB" id="79830at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
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    </dbReference>
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            <begin position="1442"/>
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            <dbReference type="EMBL" id="PCH37293.1"/>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JCM9</accession>
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        <recommendedName>
            <fullName evidence="10">1,3-beta-glucanosyltransferase</fullName>
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        <name evidence="13" type="ORF">WOLCODRAFT_92041</name>
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        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD-104</strain>
        </source>
    </reference>
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        <text evidence="10">Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall.</text>
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        <subcellularLocation>
            <location evidence="1">Cell envelope</location>
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            <topology evidence="10">GPI-anchor</topology>
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            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 72 family.</text>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0042124">
        <property type="term" value="F:1,3-beta-glucanosyltransferase activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071970">
        <property type="term" value="P:fungal-type cell wall (1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS1"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
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    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013423420" description="1,3-beta-glucanosyltransferase" evidence="10">
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            <begin position="20"/>
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        </location>
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    </evidence>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="SMART" id="SM00768"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH36489.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="553" mass="57358" checksum="BD7522401BFFEAA8" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JCY3</accession>
    <name>A0A2H3JCY3_WOLCO</name>
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        <submittedName>
            <fullName evidence="4">Inosine monophosphate dehydrogenase</fullName>
        </submittedName>
    </protein>
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        <name evidence="4" type="ORF">WOLCODRAFT_110777</name>
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    <organism evidence="4 5">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467998">
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    <sequence length="325" mass="34674" checksum="CB461FC078808F89" modified="2018-01-31" version="1">MLVTALTKLLNIRIPIIQGGMQWVGLPQLAAAVSNSGGLGILTALTQPDPNALRLAIRETRKLTPKPFGVNITLLPTINPPDYEGYARAALEEGVMIFETAGNNPAHLVKSFKDHGCIVIHKCTNIRHAKSAARLGVDVLSIDGFECAGHGGEEDIGGLVLLAKAAQELDIPYIASGGIATGRGLAAALALGAAGANIGTRFLCTVESPIHQSIKDKIVASKEQDTVHIFRTLRNTARVYRNTVSEQVIALESLPGGARFDELRDLVSGQRGRRVFETGDPDYGIWSAGVALGLINDCPTCEELLRRMEREAEEAIKGMAELVQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JDP4</accession>
    <name>A0A2H3JDP4_WOLCO</name>
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        <recommendedName>
            <fullName evidence="10">HRDC domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="11" type="ORF">WOLCODRAFT_162269</name>
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        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Phaeolaceae</taxon>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD-104</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
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        <text evidence="8">Belongs to the exosome component 10/RRP6 family.</text>
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        <property type="entry name" value="Putative exosome component 10"/>
        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50967">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5" id="KW-0271">Exosome</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="HRDC" evidence="10">
        <location>
            <begin position="492"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="415"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="766"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="134"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
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            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
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        </location>
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        <source>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00043957"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PCH40326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="857" mass="94695" checksum="2A59BD8C5FAF3ECC" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JE02</accession>
    <name>A0A2H3JE02_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WOLCODRAFT_22530</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH34197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JE02"/>
    <dbReference type="STRING" id="742152.A0A2H3JE02"/>
    <dbReference type="OMA" id="MVPDPHC"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051834">
        <property type="entry name" value="RING_finger_E3_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45931:SF3">
        <property type="entry name" value="RING ZINC FINGER-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45931">
        <property type="entry name" value="SI:CH211-59O9.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
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    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="262"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="80"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="316"/>
            <end position="411"/>
        </location>
    </feature>
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        <location>
            <begin position="100"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="124"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
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            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="370"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PCH34197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="411" mass="42980" checksum="80D8FECFD3C1A3BF" modified="2018-01-31" version="1">MSSREAAWYCHECHSETHPLMVPDPHCERCHSDFVEMIENAADDPRAPQAPPFGDYGDDTFPPDVDSFFAATRALLGAFAPHPPREADPARASSRQRTQSMGGSPRSGPGEPSGSGMTIRISGSPGGGHTMIIGGGGGGGGGGGSRSGRGPRLAGDGEMPGDGGMPGELMTRYLLAMLASQGRGEGRARLTEIMGGLFPMAEGAENGRWGDYVYNQEALDQIITHIMETSNAHAPVPATEEVMQNLPRSVLEKGSTLLGRDCAVCKEEFRTDAEDADELVVVTLPCQHPFHESCIMPWLKSSGTCPVCRYQLVPQPDSHAPGPGPPGGSAPSPENPRRRSGSGGGSSGTNFLSSFFGGLGGSGSSGSSGTGNSSSSNNNNNQGSSRNNQSSSRRQHQDSIPGGWDEPMELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JE63</accession>
    <name>A0A2H3JE63_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_148321</name>
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    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="PCH34257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JE63"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH34257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="50" mass="5733" checksum="A53033D50166E6E7" modified="2018-01-31" version="1">MPFGMVLMVDKERKRIVIIISPLDELGNDQAERFNVMGLSAFIFQAFQDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JEM5</accession>
    <name>A0A2H3JEM5_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GPI-anchor transamidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WOLCODRAFT_99130</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD-104</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C13 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH40692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JEM5"/>
    <dbReference type="STRING" id="742152.A0A2H3JEM5"/>
    <dbReference type="OMA" id="KHLRHIF"/>
    <dbReference type="OrthoDB" id="192611at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003923">
        <property type="term" value="F:GPI-anchor transamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1460:FF:000003">
        <property type="entry name" value="GPI-anchor transamidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028361">
        <property type="entry name" value="GPI_transamidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001096">
        <property type="entry name" value="Peptidase_C13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48067">
        <property type="entry name" value="GPI-ANCHOR TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48067:SF1">
        <property type="entry name" value="GPI-ANCHOR TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01650">
        <property type="entry name" value="Peptidase_C13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500138">
        <property type="entry name" value="GPI8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019663">
        <property type="entry name" value="Legumain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00776">
        <property type="entry name" value="HEMOGLOBNASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028264644" description="GPI-anchor transamidase" evidence="7">
        <location>
            <begin position="27"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="397"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR019663-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PCH40692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="418" mass="46376" checksum="61C74CE332FC9900" modified="2018-01-31" version="1">MRTFAAWCGIFSLLTCLLSLCGTSAAEPSARNAPVENFFAGRGGGGSAHTNNWAVLVCSSRYWFNYRHMANALGMYRTVKRLGIPDSNIILMLADDAACNARNKFPGCVYANQGRHLDLYGDNIEVDYRGYEVTVENFLRVLTGRMDPSVPRSKRLLTDDRSNIFVYMTGHGGNEFLKFQDNEEISAFDIADAFEQMWQKKRYNEILFMIDTCQANTMFSKFYSPNIIATGSSEIHENSYSHENDFDIGVAVIDKFTHYILQFMEGINKTSQATLQDLFNTYDFSKIESHAGVRADLFRRPLTETLVTDFFGGVAQAEVLDESASPSACALQPPSADGIQATLAIQMPGLELLLTEPVNTTLNRGPTGPRRALETDCTGLSLAAARGTADDLLARKARAWASSFVIVVLIGFVNMRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JFF4</accession>
    <name>A0A2H3JFF4_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_146653</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467931">
        <property type="protein sequence ID" value="PCH37469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JFF4"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH37469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="307" mass="35196" checksum="B0BE08753CC3B5E6" modified="2018-01-31" version="1">MYSPPMQLSQFISVAELALNMCKFGTFSEMQRLIQALPSLARIYLRRIECGRLPRLSTLDIRRCSSAFCNAMFSWLSLTESTQTLSVLKVNDVTCFPEWDDIINYGFLRRFLCHVELSLKCLHVDCLLSPDSGLSRSTTRLHSLQWLQTSLNMSRDSSEVRRLAKILSEAAFNELRVIDLAVDIGDISVDIDLRQWKDIDDLCSLPRLPALRAFEVELIWGGLLNIPDEAVIDERVGQTISRFRNQLSGIHERRVLLVTESVESREHHYWNSYTEEDVDFPELSTLKERSEEDSLSDLSEISSVLDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JFQ4</accession>
    <name>A0A2H3JFQ4_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Translationally-controlled tumor protein homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WOLCODRAFT_69648</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TCTP family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH41026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JFQ4"/>
    <dbReference type="STRING" id="742152.A0A2H3JFQ4"/>
    <dbReference type="OMA" id="CAMITEG"/>
    <dbReference type="OrthoDB" id="10248936at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.150.10:FF:000002">
        <property type="entry name" value="Translationally-controlled tumor protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.10">
        <property type="entry name" value="Metal Binding Protein, Guanine Nucleotide Exchange Factor, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011323">
        <property type="entry name" value="Mss4/transl-control_tumour"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034737">
        <property type="entry name" value="TCTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018103">
        <property type="entry name" value="Translation_control_tumour_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018105">
        <property type="entry name" value="Translational_control_tumour_p"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11991">
        <property type="entry name" value="TRANSLATIONALLY CONTROLLED TUMOR PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11991:SF0">
        <property type="entry name" value="TRANSLATIONALLY-CONTROLLED TUMOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00838">
        <property type="entry name" value="TCTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01653">
        <property type="entry name" value="TCTPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01003">
        <property type="entry name" value="TCTP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51797">
        <property type="entry name" value="TCTP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TCTP" evidence="4">
        <location>
            <begin position="1"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00014759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PCH41026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="168" mass="18886" checksum="658DC6A188769D63" modified="2018-01-31" version="1">MLLYSDVLSGDEMFSDAFPIKEVDGIVYEVDCSLITVKAGADVDIGANPSSEEQDEALEDGATQVNNVVYSFRLQSTQFDKKTFLTYLKGYMKAVKTSLQETNPDRVEAFEKGAQAFAKKLVANFKDYEFYTGESMNPDGMVALLNYREDGITPYFTFWKDGLKEIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JGB8</accession>
    <name>A0A2H3JGB8_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">WD40 repeat-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WOLCODRAFT_95877</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH37809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JGB8"/>
    <dbReference type="STRING" id="742152.A0A2H3JGB8"/>
    <dbReference type="OMA" id="CPIHPDD"/>
    <dbReference type="OrthoDB" id="4703at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052416">
        <property type="entry name" value="GTF3C_component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15052:SF2">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15052">
        <property type="entry name" value="RNA POLYMERASE III TRANSCRIPTION INITIATION FACTOR COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PCH37809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="765" mass="84202" checksum="9E94FAD288DD6E58" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JGL2</accession>
    <name>A0A2H3JGL2_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Signal peptidase subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WOLCODRAFT_140110</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Essential component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Essential for the SPC catalytic activity, possibly by stabilizing and positioning the active center of the complex close to the lumenal surface. Essential for viability.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the SPCS3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467865">
        <property type="protein sequence ID" value="PCH35854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JGL2"/>
    <dbReference type="STRING" id="742152.A0A2H3JGL2"/>
    <dbReference type="OMA" id="FWDDGHG"/>
    <dbReference type="OrthoDB" id="10261524at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007653">
        <property type="entry name" value="SPC3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12804">
        <property type="entry name" value="MICROSOMAL SIGNAL PEPTIDASE 23 KD SUBUNIT SPC22/23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12804:SF0">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04573">
        <property type="entry name" value="SPC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016089">
        <property type="entry name" value="SPC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR016089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PCH35854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="177" mass="19961" checksum="94F5322461F7FD39" modified="2018-01-31" version="1">MHSLYSRFNNATAFLSSCLMALLAAIALSSFLFTADPKGDIAIGSIQVLPGNARRYANKRQEFAFVNFNVTADLTSLFNWNTKQLFLYVSAEYTNQQGVANEVVIWDQIVHREEDARISVAGRNKYHFRELSASFRDVSPAFYTLKYNVMPYVGVLTYGEAARTPNPVPFPEQQQLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JGL4</accession>
    <name>A0A2H3JGL4_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="7">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WOLCODRAFT_162457</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 11">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 11">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="7"/>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH40685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JGL4"/>
    <dbReference type="STRING" id="742152.A0A2H3JGL4"/>
    <dbReference type="OMA" id="QSTMPID"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07415">
        <property type="entry name" value="MPP_PP2A_PP4_PP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000005">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="8">
        <location>
            <begin position="109"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PCH40685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="305" mass="34679" checksum="02133E10466E23A3" modified="2018-01-31" version="1">MPSDLDRQIEQLNRCEPISEEDVKRLCIKAREILIEEANVQVVDSPVTICGDIHGQFWDMMELFKVGGSCPQANYLFMGDFVDRGFYSVETFLLLLALKVRYPERITLIRGNHESRQITQVYGFYDECQRKYGSSNVWRWCCEVFDYLALGAIVDGRVFCVHGGLSPNLSQIDQIRAIDRKQEVPHDGPMCDLLWSDPDDIQGWGLSPRGAGYLFGADIAKMFAHGNAIDLIARAHQLAMEGYKLMFDRTIVTVWSAPNYCYRCGNVASILEIDDNLGQEYKVFTHAPSDVRSIPAKRPPADYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JGT0</accession>
    <name>A0A2H3JGT0_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WOLCODRAFT_69723</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH41386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A2H3JGT0"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="95"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="414"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="246"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PCH41386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="556" mass="59274" checksum="8707E0D26225B15F" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JGX1</accession>
    <name>A0A2H3JGX1_WOLCO</name>
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        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WOLCODRAFT_137382</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH41422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JGX1"/>
    <dbReference type="STRING" id="742152.A0A2H3JGX1"/>
    <dbReference type="OMA" id="DFRCDAW"/>
    <dbReference type="OrthoDB" id="432483at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05574">
        <property type="entry name" value="STKc_phototropin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:001236">
        <property type="entry name" value="AGC/RSK protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000121">
        <property type="entry name" value="Serine/threonine-protein kinase nrc-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45637">
        <property type="entry name" value="FLIPPASE KINASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="319"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="12">
        <location>
            <begin position="604"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="46"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="217"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="639"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="59"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="92"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="140"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="234"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="267"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="639"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="666"/>
            <end position="679"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PCH41422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="706" mass="76312" checksum="6614A8DDFCC8134F" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JH99</accession>
    <name>A0A2H3JH99_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Prolyl endopeptidase</fullName>
            <ecNumber evidence="7">3.4.21.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WOLCODRAFT_89370</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of Pro-|-Xaa &gt;&gt; Ala-|-Xaa in oligopeptides.</text>
            <dbReference type="EC" id="3.4.21.26"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the peptidase S9A family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="7"/>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH41552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JH99"/>
    <dbReference type="STRING" id="742152.A0A2H3JH99"/>
    <dbReference type="OMA" id="LDPWFSH"/>
    <dbReference type="OrthoDB" id="248387at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070012">
        <property type="term" value="F:oligopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.120:FF:000001">
        <property type="entry name" value="Prolyl endopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000005">
        <property type="entry name" value="Prolyl endopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.120">
        <property type="entry name" value="Prolyl oligopeptidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002471">
        <property type="entry name" value="Pept_S9_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023302">
        <property type="entry name" value="Pept_S9A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002470">
        <property type="entry name" value="Peptidase_S9A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051167">
        <property type="entry name" value="Prolyl_oligopep/macrocyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42881">
        <property type="entry name" value="PROLYL ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42881:SF2">
        <property type="entry name" value="PROLYL ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02897">
        <property type="entry name" value="Peptidase_S9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00862">
        <property type="entry name" value="PROLIGOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50993">
        <property type="entry name" value="Peptidase/esterase 'gauge' domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00708">
        <property type="entry name" value="PRO_ENDOPEP_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S9A N-terminal" evidence="9">
        <location>
            <begin position="15"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="8">
        <location>
            <begin position="528"/>
            <end position="740"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU368024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PCH41552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="746" mass="84100" checksum="8FA64C1353236916" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JHB3</accession>
    <name>A0A2H3JHB3_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="9">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WOLCODRAFT_27888</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 14">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 14">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PPP phosphatase family. PP-1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="9"/>
    <dbReference type="EMBL" id="KB467843">
        <property type="protein sequence ID" value="PCH35397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JHB3"/>
    <dbReference type="STRING" id="742152.A0A2H3JHB3"/>
    <dbReference type="OMA" id="EEHEIRY"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007346">
        <property type="term" value="P:regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07414">
        <property type="entry name" value="MPP_PP1_PPKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000007">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031675">
        <property type="entry name" value="STPPase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF300">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16891">
        <property type="entry name" value="STPPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="11">
        <location>
            <begin position="122"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="311"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PCH35397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="332" mass="38110" checksum="4C6BB15F6622EF76" modified="2018-01-31" version="1">MADSATEIDLDSVIDRLLEVRGNRPGRPVQLQEYEIKYLCTKAREIFINQPILLELEAPIKICGDIHGQYYDLLRLFEYGGFPPEANYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFVLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIIDEKIFTMHGGLSPDLQSMEQIRRVMRPTDVPDTGLLCDLLWSDPDKDITGWSENDRGVSFTFGPDVVSRFLQKHDMDLICRAHQVVEDGYEFFAKRHLVTLFSAPNYCGEFDNAGAMMSVDETLLCSFQILKPAEKKAKYPYGGVNMGRPVTPPRKQKKKDASKMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JHG8</accession>
    <name>A0A2H3JHG8_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein-serine/threonine kinase</fullName>
            <ecNumber evidence="7">2.7.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WOLCODRAFT_24420</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the PDK/BCKDK protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="7"/>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH41005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JHG8"/>
    <dbReference type="STRING" id="742152.A0A2H3JHG8"/>
    <dbReference type="OMA" id="AAYYPPE"/>
    <dbReference type="OrthoDB" id="3264224at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004740">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010906">
        <property type="term" value="P:regulation of glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.20">
        <property type="entry name" value="Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036784">
        <property type="entry name" value="AK/P_DHK_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018955">
        <property type="entry name" value="BCDHK/PDK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039028">
        <property type="entry name" value="BCKD/PDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947:SF25">
        <property type="entry name" value="[PYRUVATE DEHYDROGENASE (ACETYL-TRANSFERRING)] KINASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10436">
        <property type="entry name" value="BCDHK_Adom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69012">
        <property type="entry name" value="alpha-ketoacid dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase N-terminal" evidence="9">
        <location>
            <begin position="45"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase/HSP90-like ATPase" evidence="8">
        <location>
            <begin position="262"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PCH41005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="437" mass="49914" checksum="D786DE00B5438DB2" modified="2018-01-31" version="1">MLVRSGLRFRSSRARPLRQYRSLSSALHFYQNRQLEQYASKDAQRLTLRQLIFFGRSMNEDRLIKSANYVRNELPVRIAHRLRDMQTLPYVVMNQEGIADVYEAYCTAFDKFRRYPPVSNMAENEEFCKFLRAILDDHRRAIPNLSLGMSLSSPYLPPDRLDPFMRRMLVSRISRRVLVEHHIALSKVVSAKQRGEPVPENRVGIINLSLHVKDSIERCAMYLRKRPFNVDQDCRMGAACDAGWSEVIVDGHLDTKFSYIQAHLDYIVFELLKNSFRATRLKHRDSQHLPPIRATIVAGENDVAIRISDQGGGLLTSEIRSPSDLFSFSHLRNPTRLDPSRIEALRAVSSSGRGMTATVDEQVQAWENDARKIDQDNPEHRAGVSPHPRTGIGLPMSNIFATYFGGSLELVSLDGYGTDVYLRLPKLGTNLEGIELW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JHI6</accession>
    <name>A0A2H3JHI6_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Beach-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WOLCODRAFT_140755</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467909">
        <property type="protein sequence ID" value="PCH37188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="742152.A0A2H3JHI6"/>
    <dbReference type="OMA" id="PHEQIEW"/>
    <dbReference type="OrthoDB" id="26681at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06071">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1540.10">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056252">
        <property type="entry name" value="Alfy-like_Arm-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000409">
        <property type="entry name" value="BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036372">
        <property type="entry name" value="BEACH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051944">
        <property type="entry name" value="BEACH_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046851">
        <property type="entry name" value="NBCH_WD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023362">
        <property type="entry name" value="PH-BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46108">
        <property type="entry name" value="BLUE CHEESE"/>
        <property type="match status" value="1"/>
    </dbReference>
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</entry>
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    <accession>A0A2H3JHI8</accession>
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        </lineage>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
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                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
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    </dbReference>
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        </location>
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        </source>
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        <source>
            <dbReference type="EMBL" id="PCH39303.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
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</entry>
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        <alternativeName>
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        </alternativeName>
    </protein>
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        <lineage>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
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                <person name="Heitman J."/>
                <person name="Hesse C."/>
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                <person name="Kallen N."/>
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    </feature>
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        <source>
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    </evidence>
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        <source>
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                <person name="Barry K."/>
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</entry>
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            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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        </source>
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        <source>
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    </evidence>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="233" mass="27136" checksum="06BF6B714636EDF7" modified="2018-01-31" version="1">MAPPAFLLVFSEPGPNVSEEEFHDWYDNEHIPLRVNTMNWTRWKAIDGEKPAYGASHDLVSYEETKKAPYTTLAETRSGREKDILSRIETLDRRHYELYEGPTTPPSTLYSESHPAPYGVFVSLDLKPEYEEEFNKWYDEEHIPMLARAPGWVRTRRFVLKDHGQLGAGGRSEQIQRPPKYLAVHEWSSLAGFESKEYKEAMATPRRNRIYAGVIGKERRVMSFLRKWDRVSS</sequence>
</entry>
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    <accession>A0A2H3JIR2</accession>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Barry K."/>
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                <person name="Martinez A.T."/>
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                <person name="Spatafora J.W."/>
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                <person name="Benoit I."/>
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                <person name="Ferreira P."/>
                <person name="Findley K."/>
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                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
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                <person name="Heitman J."/>
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                <person name="Kallen N."/>
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                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
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                <person name="Sabat G."/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="336"/>
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    </feature>
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        </location>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH38659.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
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    <name>A0A2H3JIT1_WOLCO</name>
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            <fullName evidence="3">Sec7-domain-containing protein</fullName>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
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                <person name="Sun S."/>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
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                <person name="Benoit I."/>
                <person name="Boyd A."/>
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                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
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                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
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                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
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                <person name="Ohm R.A."/>
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                <person name="Sabat G."/>
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                <person name="Martin F."/>
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                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">MD-104</strain>
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            <dbReference type="EMBL" id="PCH39009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="241" mass="26730" checksum="8AA3424E2C100717" modified="2018-01-31" version="1">MPFDALSSRSHQLREAAKRQVPDVAVRLASLNALCTVIQKNVVVVYSHYKIQHMRATPIPDGGVKGHGGSIGSTAHDLFETAVAGCESSYRSGYETSWNGVAAIAALQRDFEIYDIWLAVRRIRCIGWMPSIFPDPEEFRPEQWIKEEGALEQYQLFFAFSTGSCVTGDEGAAQKSLLELPDTRRRRDDGVEGAGQPDHCLSSDRPKVSYIAREGCMTCNDRCIELGEGQQQTLSLSLEKM</sequence>
</entry>
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        </lineage>
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    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
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                <person name="Copeland A."/>
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                <person name="Ferreira P."/>
                <person name="Findley K."/>
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                <person name="Heitman J."/>
                <person name="Hesse C."/>
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                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
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                <person name="Kohler A."/>
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                <person name="Morgenstern I."/>
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                <person name="Murat C."/>
                <person name="Nagy L.G."/>
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                <person name="Patyshakuliyeva A."/>
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                <person name="Ruiz-Duenas F.J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD-104</strain>
        </source>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF09364">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS60002">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS60003">
        <property type="entry name" value="PHOSPHOKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase N-terminal" evidence="6">
        <location>
            <begin position="35"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase C-terminal" evidence="5">
        <location>
            <begin position="600"/>
            <end position="803"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005623"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF09363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF09364"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH42151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="807" mass="89212" checksum="762202E96A4E8E5A" modified="2018-01-31" version="1"> </sequence>
</entry>
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        <name evidence="1" type="ORF">WOLCODRAFT_137968</name>
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        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
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            <taxon>Agaricomycetes</taxon>
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            <taxon>Phaeolaceae</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="742152.A0A2H3JK47"/>
    <dbReference type="OMA" id="ATWNKRE"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.580">
        <property type="entry name" value="Acetamidase/Formamidase-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FmdA_AmdA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="NCBIfam" id="NF045496">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31891">
        <property type="entry name" value="FORMAMIDASE C869.04-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03069">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="PCH42566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="421" mass="45404" checksum="14F3F0747FFC9C9D" modified="2018-01-31" version="1">MATRANSVPHPTLVQVDPFISAHEQRGIHNRWHPDIPAFATVKPGQVFNIECVDWTGAQIGNNDCSDDVKNVDLTKIHNLSGPIAVEGAEPGDCLVVDILDVRPFDKMPWGYTGIFELENGGGLFAREFNSRAAKAIWDFHGVYATSRHIPGVRFAGVSHPGLIGTAPSAELLATWNKREGELVAANPNAVPPVAFLPNATGAYVGQELPNDVREKIYREGARTVPGREHGGNCDIKNLSRGSRCYFPVFVKGANLSVGDLHFSQGDVKISFCGAIEMAGIITFSTSIIKGGVEKFALKQPIFLPSPVDPLYSAKLVFEGISVDVHGDGKQYDMDATVAYKQAALNAITYLMKLGYTREQAYLLLSAAPVESHVGAIVDSPNACVTLALPLGIFEHDILPKEEGLTKKNFGQCAIRSDGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JKV6</accession>
    <name>A0A2H3JKV6_WOLCO</name>
    <protein>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
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        <lineage>
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            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="PCH42501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JKV6"/>
    <dbReference type="STRING" id="742152.A0A2H3JKV6"/>
    <dbReference type="OMA" id="MVETHKI"/>
    <dbReference type="OrthoDB" id="2538461at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="54"/>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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            <end position="248"/>
        </location>
    </feature>
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        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH42501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="312" mass="34768" checksum="D61FB94E2A679FB6" modified="2018-01-31" version="1">MFKRVLKRRRRQEEDEELGLDGETKEMLGWRDIDDSSSDSDSDSDSASDNSGGEPDERDVFDEDMDDEEDEIEQSDDDEEGSDAEEPPVSLAEALKDPLYTVSQEPDVQACIVCPGKIFKHETSVEVHRSSNAHIRKFKRFVQAAEKLGPDADVKDVLMAADDVAKSGMKKEEGEPSKRQLKRQAREAAIAAKRKKRKELKATGIARKATKALTESEQSTSEKHSQANGHAQKERKVDSKQRKVESIRKPSSRTTREATQSPQTAKTVTKSDLTKSSKPYKVLKPNKSEQKAAETAATPKPGTKRKRAAKDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JL18</accession>
    <name>A0A2H3JL18_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
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                <person name="Larrondo L.F."/>
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                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
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                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
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                <person name="St John F."/>
                <person name="Stenlid J."/>
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                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="742152.A0A2H3JL18"/>
    <dbReference type="OMA" id="DIKAGHN"/>
    <dbReference type="OrthoDB" id="202203at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH37344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="165" mass="18460" checksum="E546267A260B137F" modified="2018-01-31" version="1">MQLYSMDRRKTTRVKRTMQVAVPNNPAAPDMPVDSATEGGDEHLHVPYPHLFAIGDTADAFGAMNSGRSSYFQAEVATSNILKLINHSERLRTHGNAGDQADSSNDDFEQFTPGPPMIKTTLSLTKQLYEVDGEVGMKMDGTPDLEVHRMWQFYGVETDEDKMYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JL93</accession>
    <name>A0A2H3JL93_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
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    <gene>
        <name evidence="13" type="ORF">WOLCODRAFT_102882</name>
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            <taxon>Basidiomycota</taxon>
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            <taxon>Agaricomycetes</taxon>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
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                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
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                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
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                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
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                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
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                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
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                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
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                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
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                <person name="Young D."/>
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                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Martinez A.T."/>
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                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
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                <person name="Copeland A."/>
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                <person name="Ferreira P."/>
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                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
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                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
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                <person name="Grigoriev I.V."/>
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        </citation>
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            <strain evidence="1 2">MD-104</strain>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="264" mass="30537" checksum="6AB8D35A79B24526" modified="2018-01-31" version="1">MTNRQYHKVLDNLQRLVIQRLFELHRMNISQTGYHVRVYIAKLLQARSKAIRNAVKIYNQAALKLDPPKPTVDWERVSHYNFLEDFHLLRDTRNSVMDKPWTWPAIRETMKQARRIERAQEEIEHCNVEVRRLHTSIRDEEAHFSNVLARLKAEQSRVYRAVAEYCERRRNINARHLDQLEKLYKLKGFTGIPCPGTHNHVAVVGVRVFPADVINRGDDQPATECTNILTGGTLDAEDAEADAINDEGEVEMGALVDFVSNLAM</sequence>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
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                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
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                <person name="Benoit I."/>
                <person name="Boyd A."/>
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                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
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                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
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                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
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                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
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                <person name="Stenlid J."/>
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                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
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                <person name="Spatafora J.W."/>
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                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
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                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
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                <person name="Ohm R.A."/>
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                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">MD-104</strain>
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    </evidence>
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        <source>
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    </evidence>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Martinez A.T."/>
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                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
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                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
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                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
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                <person name="Stenlid J."/>
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                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">MD-104</strain>
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            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
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                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
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                <person name="Sabat G."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH40009.1"/>
        </source>
    </evidence>
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        </source>
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</entry>
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                <person name="Barry K."/>
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                <person name="Martinez A.T."/>
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                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
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                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
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                <person name="Morgenstern I."/>
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                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
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                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
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            </authorList>
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        </source>
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        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="177" mass="20374" checksum="0A13604050436739" modified="2018-01-31" version="1" fragment="single">WISACVWMKIKITAQQAQSALNDYRARFSDQHQAELNGNSGPAGRKPFSNEAFLDAICDWVVADDQAINAIECAELRAIFLMLREDLRDTDIPHRTTVRERVRAMWAEHLTYLEKELKHLAIAFTHILDRIGISSQLGWITLNNASNNGTFMRCLEAELKLRGIAFDHMQRRIRYAM</sequence>
</entry>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
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                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
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                <person name="Ferreira P."/>
                <person name="Findley K."/>
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                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
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                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
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        <property type="entry name" value="AB_hydrolase_fold"/>
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    </dbReference>
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        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="40"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH37587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="345" mass="38879" checksum="9F0FC505FF062397" modified="2018-01-31" version="1">MSLSCESYVCDARPDYPLLITAKRYWVPGLASDDPSALTLILTHGTGYHKEQWEPTIEHLYEHLAGQSPVRVRDVWSIDCPNHGEAAVLNEQTLRWGYHIFNWEEYARAVHIFLTGQGRGIDVDFSKRNLIGIGHSMGAVALILCSTFSPKPAFRSFIFAEPMCFPPEPYGLPDKFTTFLTTGAEKRRDIFESREEALLWLKSRAGFKVWDERVLKAFVDHGMRDLPTVDYPDKTSGVTLKCTRAQEAACYRDHTNTGRVRAYNYLATLCAVYPVHVLYGAVDDYIPSQVKDYILTEGTQGKHTSARRVQNSGHLMVQTQPKGLAEAIWAVLEGVPAPVWVLSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JNM8</accession>
    <name>A0A2H3JNM8_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Beta-xylanase</fullName>
            <ecNumber evidence="10">3.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WOLCODRAFT_103638</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-xylosidic linkages in xylans.</text>
            <dbReference type="EC" id="3.2.1.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan degradation; xylan degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the glycosyl hydrolase 10 (cellulase F) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.8" evidence="10"/>
    <dbReference type="EMBL" id="KB468146">
        <property type="protein sequence ID" value="PCH43501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JNM8"/>
    <dbReference type="STRING" id="742152.A0A2H3JNM8"/>
    <dbReference type="OMA" id="CVGFTIW"/>
    <dbReference type="OrthoDB" id="3055998at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031176">
        <property type="term" value="F:endo-1,4-beta-xylanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044846">
        <property type="entry name" value="GH10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001000">
        <property type="entry name" value="GH10_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490:SF35">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00331">
        <property type="entry name" value="Glyco_hydro_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00134">
        <property type="entry name" value="GLHYDRLASE10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00633">
        <property type="entry name" value="Glyco_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51760">
        <property type="entry name" value="GH10_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 10 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013722860" description="Beta-xylanase" evidence="11">
        <location>
            <begin position="19"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="GH10" evidence="12">
        <location>
            <begin position="34"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PCH43501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="359" mass="39286" checksum="D8A6D7E906970FCC" modified="2018-01-31" version="1">MAIAALTTLVALAHIAVAIPQTATAASSALPTATAVVPGLNFVAKSAGKLYFGTATDNPELNDTAYDHILDNFLQFGAITPANSMKWDATEPEPYVFTFEAGDVIADLAHENGMLLRGHNCVWYNQLPSWVTANNYTAPELAAIIQNRCATLVGHYRGQVYAWDIINEPFNDNGTYREDVFYNTLGTSYIPIALTAARAADPNAKLYINEYNNEYLGPKSTALLDLVKELKAEGVPIDGVGFQCHFVVGEVPTTMVENFQQYAAIGLEFAITELDIRMPLPATPEMLEQQKTDYDTVVSACMAVPNCVGISVWDWTDKYSWIPSTYPGYGEACPWDANFVRKPAYDGIVIALENRTSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JP85</accession>
    <name>A0A2H3JP85_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_75433</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468146">
        <property type="protein sequence ID" value="PCH43701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JP85"/>
    <dbReference type="STRING" id="742152.A0A2H3JP85"/>
    <dbReference type="OrthoDB" id="5599163at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH43701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="71" mass="8385" checksum="E5E7506CDD80CC11" modified="2018-01-31" version="1" fragment="single">LNERVLAFEEYHRGTFCEDYFTPYIIPVIEHKPWEFVNIPIPPGIHEHVISLLKEKIADDVYEPGQSPYRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JPB6</accession>
    <name>A0A2H3JPB6_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_90250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468135">
        <property type="protein sequence ID" value="PCH43335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JPB6"/>
    <dbReference type="STRING" id="742152.A0A2H3JPB6"/>
    <dbReference type="OMA" id="TTHRHIN"/>
    <dbReference type="OrthoDB" id="3052721at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH43335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="200" mass="22137" checksum="0E7E3374E25F9F40" modified="2018-01-31" version="1">MSQWLTHTFKLLHCRTYTLEARALAQLLVKSGASQRSVGGVIQKMTSMMGAKVDHCMSQQMVACTVLEGGVAAQIQLAHKITQMKSEMALRIGSTTHRHINYESRHVTMRVSEYENPPHSHINAVAPIPKMCLIGVDTSVDHTSETQVAGWKQRMSNLSEICAISPLAQHSQQTFNADNFVLKLKGMNGDHAEDQKKPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JPG1</accession>
    <name>A0A2H3JPG1_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6535 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_70035</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH41793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JPG1"/>
    <dbReference type="STRING" id="742152.A0A2H3JPG1"/>
    <dbReference type="OMA" id="NELWFAS"/>
    <dbReference type="OrthoDB" id="3219854at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045338">
        <property type="entry name" value="DUF6535"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20153">
        <property type="entry name" value="DUF6535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6535" evidence="2">
        <location>
            <begin position="1"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH41793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="230" mass="24753" checksum="08C9CF1E68E63EC4" modified="2018-01-31" version="1" fragment="single">KDRIDNLLVFAALFSAVLTAFVVDSYQLLRPQAADETNRILHQISQQLNSFTISNGYINSTIPTFATLPSDATSTSKEVVSGSAVLINALWFSSLVFSLTAASVGIAARQWLNHHDNVPLAVHARISVRIWHSRHIAFNDWHVGAILSTLPVLLQTALVLFLVGLVVMLKTLNNVVADIIIAQAGLLGIFSSCDAFFRTTSHGVSGAACIYRSPPLCHGSGIGAHSSNKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JPJ7</accession>
    <name>A0A2H3JPJ7_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 17">Delta-aminolevulinic acid dehydratase</fullName>
            <ecNumber evidence="5 17">4.2.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">WOLCODRAFT_138602</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 17">
            <text>2 5-aminolevulinate = porphobilinogen + 2 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58126"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="4.2.1.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 17">Homooctamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the ALAD family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.24" evidence="5 17"/>
    <dbReference type="EMBL" id="KB468146">
        <property type="protein sequence ID" value="PCH43811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JPJ7"/>
    <dbReference type="STRING" id="742152.A0A2H3JPJ7"/>
    <dbReference type="OMA" id="YQMDYAN"/>
    <dbReference type="OrthoDB" id="1530at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00318"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004655">
        <property type="term" value="F:porphobilinogen synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000048">
        <property type="entry name" value="Delta-aminolevulinic acid dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001731">
        <property type="entry name" value="ALAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030656">
        <property type="entry name" value="ALAD_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006762">
        <property type="entry name" value="PRK09283.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11458">
        <property type="entry name" value="DELTA-AMINOLEVULINIC ACID DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11458:SF0">
        <property type="entry name" value="DELTA-AMINOLEVULINIC ACID DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00490">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001415">
        <property type="entry name" value="Porphbilin_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00144">
        <property type="entry name" value="DALDHYDRTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01004">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00169">
        <property type="entry name" value="D_ALA_DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="10 17" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 17" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="14">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="14">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>5-aminolevulinate</name>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>5-aminolevulinate</name>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>5-aminolevulinate</name>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>5-aminolevulinate</name>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU004161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PCH43811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="341" mass="37438" checksum="D011B4D3126BD188" modified="2018-01-31" version="1">MDISSVLQGGYQHPLSRSWQARRHLTKSMFMYPIFITDDPDASVEIASLPGQRRWGVNKLEEFLGPLVKKGLQSVILFGVPFKCVKDERGTPADDPQGPVILAVKKLRALFPTLYIACDVCLCEYTSHGHCGLFRADGALDQVPSAARIAEVALAYAKAGAHCVAPSDMMDGRIKAIKQELMNAGFANQCTLMSYSAKFASSLYGPFRDAAGSAPAYGDRKCYQLPPQAKGLARRAIQRDINEGADIIMVKPALPYLDVIQDAAELAPNHPLACYQVSGEFAMIVAGARAGVYDLRTMAFESVESMVRAGCTLILSYFTPDFLDWLSDRLLLHSLHIEMRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JQL3</accession>
    <name>A0A2H3JQL3_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">WOLCODRAFT_29283</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KB467943">
        <property type="protein sequence ID" value="PCH38954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JQL3"/>
    <dbReference type="STRING" id="742152.A0A2H3JQL3"/>
    <dbReference type="OMA" id="FINGGEX"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11651">
        <property type="entry name" value="YPK1_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000008">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000048">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="208"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="13">
        <location>
            <begin position="466"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PCH38954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="545" mass="61691" checksum="1F4BAFB3C81FBCFA" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JQN2</accession>
    <name>A0A2H3JQN2_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">D-xylose 1-dehydrogenase (NADP(+), D-xylono-1,5-lactone-forming)</fullName>
            <ecNumber evidence="3">1.1.1.179</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">D-xylose-NADP dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WOLCODRAFT_138848</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>D-xylose + NADP(+) = D-xylono-1,5-lactone + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22000"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15867"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.179"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.179" evidence="3"/>
    <dbReference type="EMBL" id="KB468157">
        <property type="protein sequence ID" value="PCH44241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JQN2"/>
    <dbReference type="STRING" id="742152.A0A2H3JQN2"/>
    <dbReference type="OMA" id="NITATMY"/>
    <dbReference type="OrthoDB" id="2129491at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047837">
        <property type="term" value="F:D-xylose 1-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050984">
        <property type="entry name" value="Gfo/Idh/MocA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055170">
        <property type="entry name" value="GFO_IDH_MocA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22604">
        <property type="entry name" value="OXIDOREDUCTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22604:SF105">
        <property type="entry name" value="TRANS-1,2-DIHYDROBENZENE-1,2-DIOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GFO_IDH_MocA_C3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="10"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="GFO/IDH/MocA-like oxidoreductase" evidence="7">
        <location>
            <begin position="151"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010928"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00042988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PCH44241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="371" mass="41032" checksum="E7D93B230C64452C" modified="2018-01-31" version="1">MAPIQPFVLRWGVVSTGWIAMQFVKDCLIDPTTRGTTDVVHKVIAVGSRNGNLQKAAEFIDTYGSGQPIKAYGTYEEVYADKDVDVVYIGSPHTQHYENALAALKAGKHVLCEKPSTSNTAELRHLLSVAKERNLFFMEAMWTRFQPLAKEVKRIAEEGALGDPVVVHADFAFDFYIDTLPKTHRMLDPQLGGGAVLDLGPYPMFWTILALYEHPSNKKALPTSVSAAMVKTPITGVDSITSWTVNFTSTLRAQAILSCTMMAPSAPFGATIRYRGGNIIIGTPIAIPTTFTVQYFDKPGSGTVVREEKRVFEYVGGGWHYEADEVARCVRDGKLESELWGHDKSLLLMNVLDEVRRQGDYKLPDGVEKVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JQT5</accession>
    <name>A0A2H3JQT5_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UBC-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_76779</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468157">
        <property type="protein sequence ID" value="PCH44506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="742152.A0A2H3JQT5"/>
    <dbReference type="OMA" id="FTNYHPE"/>
    <dbReference type="OrthoDB" id="1158011at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 J2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UBC-like"/>
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    </dbReference>
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        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="2">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH44506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="149" mass="16754" checksum="4489A28286BA25F0" modified="2018-01-31" version="1">MQRDPPPFVWAVPEEKNILTWHYIIRGPPDSPFAGGEYHGVLLFPSEYPFKPPGIKMLTPSGRFQPDRKICFSMSDFHPGSWNPAWSVSTILTGLLSFMLSDEMTTGSTTTTDADKRAYAARSHAYNLGQRKFKEVFPDVSSIITLILT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JQV1</accession>
    <name>A0A2H3JQV1_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Cytochrome c oxidase subunit 9, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 12">Cytochrome c oxidase polypeptide VIIA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">WOLCODRAFT_104904</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the fungal cytochrome c oxidase subunit 7a family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468157">
        <property type="protein sequence ID" value="PCH44311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JQV1"/>
    <dbReference type="STRING" id="742152.A0A2H3JQV1"/>
    <dbReference type="OMA" id="VHLKHVQ"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22888">
        <property type="entry name" value="CcO_VIIa_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014368">
        <property type="entry name" value="Cyt_c_oxidase_su7a_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28264:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 6C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28264">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000283">
        <property type="entry name" value="COX9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR000283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PCH44311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="58" mass="6792" checksum="30EB50FF9CACC541" modified="2018-01-31" version="1">MPIAPITGKLRKRFWLDLSVALGMGVSAGYAFWYGVHLKHVQRQEEFYLKLERAKQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JR42</accession>
    <name>A0A2H3JR42_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_26743</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Igarashi K."/>
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                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
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                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
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                <person name="Lindquist E."/>
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                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
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                <person name="Nagy L.G."/>
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                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Barry K."/>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
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                <person name="Benoit I."/>
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                <person name="Gaskell J."/>
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                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts with the iron-sulfur protein subunit within the SDH catalytic dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the complex I LYR family. SDHAF3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB468124">
        <property type="protein sequence ID" value="PCH42399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JU22"/>
    <dbReference type="STRING" id="742152.A0A2H3JU22"/>
    <dbReference type="OMA" id="WQQTNEN"/>
    <dbReference type="OrthoDB" id="278329at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034553">
        <property type="term" value="P:mitochondrial respiratory chain complex II assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006105">
        <property type="term" value="P:succinate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20270">
        <property type="entry name" value="Complex1_LYR_SDHAF3_LYRM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008381">
        <property type="entry name" value="SDHAF3/Sdh7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13137">
        <property type="entry name" value="DC11 ACN9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13137:SF6">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13233">
        <property type="entry name" value="Complex1_LYR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4 6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PCH42399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="140" mass="15985" checksum="48807B0ED1DD27CE" modified="2018-01-31" version="1">MRSTIVRLAESISKRPLNLREANAALLPPKPLYRRILRAHRSLPYEMRSLGDDYVRAEFHRHRSVANKVHIIGFLSQWKMYLDELPVGLGAKDFAGRRLDPTVLEKMSAEQLGQLYELMNATKEVWKPQDADDAGEGSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JY94</accession>
    <name>A0A2H3JY94_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_139355</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468168">
        <property type="protein sequence ID" value="PCH44973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JY94"/>
    <dbReference type="STRING" id="742152.A0A2H3JY94"/>
    <dbReference type="OMA" id="WMGSVGT"/>
    <dbReference type="OrthoDB" id="3204900at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="198"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="369"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="135"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="205"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="369"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="408"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH44973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="441" mass="45972" checksum="DC1C1109997FCA0A" modified="2018-01-31" version="1">MNGPAKPARPLSLSAPRPLQLVDGTASPAASACPSPSPTIAGLSTPPPTARDLKPHRQSSISYKPSDSAPTWDARSPTSASAKALRRSFSLGQKADGPTLKANRRSLGSAELMSPQPERAPLTLAEKHADLLHFIAQKESKCLELRTQLAAHEEELAQLKRKWEHIVSRGMDRAARAGPSTPPPRTMPMTAPGLAALSRARGHCSSQSTSSASTGTTSTRSTSVRLSQSSASSLGLSELDEADEGCESKACTLTHRRGSRDMAAPRPSGAATKAPATPVSAKRASLSALPPPNLPGIGALAMQGPVASWMGSVGRKWGELQKDERIAKSQKRASVILSDVSQSLFSALGSPTRTSDSVSVSSNPFAAALSPLSPSSATASSDFHSRSLLEDDDDAGGLGSVMVPDLRSPTSSTSPSFSSASTRIASSPAKTMDQSDDEWNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JYE9</accession>
    <name>A0A2H3JYE9_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_152953</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468135">
        <property type="protein sequence ID" value="PCH42898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JYE9"/>
    <dbReference type="STRING" id="742152.A0A2H3JYE9"/>
    <dbReference type="OMA" id="WNDAYFN"/>
    <dbReference type="OrthoDB" id="2310150at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19075">
        <property type="entry name" value="AKR_AKR7A1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF4">
        <property type="entry name" value="NAD(P)-LINKED OXIDOREDUCTASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="10"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH42898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="339" mass="38420" checksum="8B4047EC975DEC82" modified="2018-01-31" version="1">MAAQKSALDIVMGAMTFGEAGKEGARVHDIKDVEAILDVFQAHGHTEIDTARVYSGGTSEEYLGRINWRERGLKLETKLYPNASHKFLQGPGRPLISHSPEDLRKHLELSSKALNTDQLEMWYLHGPDRTTPYEVTLRAVNDLYKEGKFKRFGISNYMAWEVAEIVQICRANGYIQPTAYQGIYNAIHRKVEPELFPCLRKYGISFYEFNPLGGGFFTGRYTSLDEKVEPGSRFDPEKGQGKMYRTRYWNEPYFKAISAIQEVAAAHGLTMAEIALRWISHHSLMKREYGDAVIIGASSLKHIEQNLIDLEKGPLPDAVVKALDDPWLSVAPYATNYFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JZ35</accession>
    <name>A0A2H3JZ35_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HET-R</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WOLCODRAFT_49375</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD-104</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
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    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="29"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="71"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="120"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="162"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="204"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="248"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PCH41994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="280" mass="30153" checksum="E443C8D03D78873A" modified="2018-01-31" version="1" fragment="single">MHRMYANEMPSISLLSPRRQQWDACLRVIGDHANAVNSVTFSPNGQWIASASGDKTVRMFDAVSGTTLNTMRGHKGRVTSVAVSPDSQFAVSGSYNGEINMEAMLHMWDPDTGECLQLAIVGEDTYVYSVAYSPDGGRIVTASGDGLVRTWDSHTLDLKARFSGHTNAVLSAVFFPDGAKLASGSLDKTIRIWDATSAQCTRILEGHTGKVNSVAVSSKGDLIASVSDDDDPSVRLWDVRYGETLAILKGHFDQVRSVGFSPEGDRLASGSDDGTVCVWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JZI6</accession>
    <name>A0A2H3JZI6_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WOLCODRAFT_104900</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468157">
        <property type="protein sequence ID" value="PCH44309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="742152.A0A2H3JZI6"/>
    <dbReference type="OMA" id="RWNRLDF"/>
    <dbReference type="OrthoDB" id="2117972at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045464">
        <property type="entry name" value="Hrt3/FBXO9_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12874:SF9">
        <property type="entry name" value="F-BOX ONLY PROTEIN 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12874">
        <property type="entry name" value="F-BOX ONLY PROTEIN 48-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19270">
        <property type="entry name" value="FBO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
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        <location>
            <begin position="212"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="31"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="73"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PCH44309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="453" mass="50863" checksum="58F0EC47BBF23D92" modified="2018-01-31" version="1">MAASERADLPGDSEDLVRFREQWKAEVRKKKLGLSSVDSGPSASVTNAVAVDGSKGTGQPLRTEGSPQAPATRDTTYVSTSVANSSGSTPYSVALTRAVEVYRRAVLAEQQSNLDEALGLYRTAFRMDSNVDRAYHKIEAQFHSVPVQPQTLRKTDKHAVDEIAQAIKALDLHSSFVPAGQNNGAAITGTLANLLAEWPRSLSFAPEDEKEAVPLQKIPYELLLHVLRSLDTTTLERFAKVSRKARVVTLDVSIWRAHVQATYKPPQIEDEEELDVLVHQYVGDHRRLFIEHPRVRMDGVYIAVCHYIRNGLSENTWVNVSHLITYHRYLRFYPNGQVLSLLANEEMPPQQVIPMLKPTLRMKGLYIGTWRLSGAIVYITSLLDPSPPSHSGTRYAFQMTLELKSRPVGRWNRLEFRAYDSVNIESGEATPLVLKHERPFWFSKVRSYIQSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-05-03" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K181</accession>
    <name>A0A2H3K181_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_17928</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468135">
        <property type="protein sequence ID" value="PCH42774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K181"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH42774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="353" mass="39839" checksum="B0BF3FE27FE55E4B" modified="2018-01-31" version="1">MYMQFSHPSKSATQSIVDADIEIAQKSLADRYTFTRQLAMEDLHSHLIKTLDKKIPWPNVKDTMFYCRTSADSRNLDLGCMAKYESATNQDHVCMSSTFPYSAWPTQNIRLLYVLPNCPHHMGRASVRSWHEPLAHEIYKGFTEFLTLCRWKNSNMIKSLADPTKVGDAISFPHWQVNKTSVYLACLHQIVGDIFQVVMAVQSDLTGVAMHKESPASLLHPLPIHAQTGEFSALVTGYASLLRHVNRTRFADAQDLREVAIERPQNLPSGQFTTFEGSRSISFGLERWSQSVGTRIGQNYMISEVLWGRSDEVEVYEETGDTSLIYVEVALAYIFSHSSTRMGRNADAGCTTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K4P3</accession>
    <name>A0A2H3K4P3_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Autophagy-related protein 27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">WOLCODRAFT_121884</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Golgi apparatus membrane</location>
            <topology evidence="4">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Preautophagosomal structure membrane</location>
            <topology evidence="3">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ATG27 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468146">
        <property type="protein sequence ID" value="PCH43397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K4P3"/>
    <dbReference type="STRING" id="742152.A0A2H3K4P3"/>
    <dbReference type="OMA" id="FRINLCE"/>
    <dbReference type="OrthoDB" id="29460at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018939">
        <property type="entry name" value="Autophagy-rel_prot_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044865">
        <property type="entry name" value="MRH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15071:SF13">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15071">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE RECEPTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09451">
        <property type="entry name" value="ATG27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50911">
        <property type="entry name" value="Mannose 6-phosphate receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51914">
        <property type="entry name" value="MRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0072">Autophagy</keyword>
    <keyword evidence="17" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="15 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 20" id="KW-0732">Signal</keyword>
    <keyword evidence="8 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013702382" description="Autophagy-related protein 27" evidence="20">
        <location>
            <begin position="25"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="21">
        <location>
            <begin position="28"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="PCH43397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="291" mass="32117" checksum="E82D3340523806F6" modified="2018-01-31" version="1">MKQASSHIQGSAAALLYLSIYAAAQETFDCHINHNGLDYDLTTVRGEHQVVRERDTPPTKMIDTVVFDLCEDLHPREGVDEKNQCPAGTRACLTKTNRKDDEGDRIVAVVPLATSERDKVEYSALSSGDNGLSLTFKGPSYPSSSGSDSKPQSFNIRLLCDSEHRDLEFMSYDGSELWVEWRTTAACGSRESADPPAGDKPADDTEDGGQSESRMGSGLGYFFLLLFLALVAYFGLGAYYNYSTYGASGMDLIPHRDFWREVPYMLRDLASHLCSAFRPRQSASRSGYIAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K4W3</accession>
    <name>A0A2H3K4W3_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_164452</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468146">
        <property type="protein sequence ID" value="PCH43457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K4W3"/>
    <dbReference type="OMA" id="ARIMLAM"/>
    <dbReference type="OrthoDB" id="2794337at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH43457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="298" mass="31909" checksum="AFA036B2A4E4A0EF" modified="2018-01-31" version="1">MSTQPFAAQWHAALAEKSCPPAYDDAPSLADARIDVRRFFAAAALQLAHTPRVGVKHPLYREWQTIEERYILLERQARYNAGQCALFLTNTVSALGQQPHASPAIGDPQSAFFEILRILSVHRDAAAHIQDGLYELQAAVSAFPAKVLEAANRPAARGALGALLSLGRKRVTQPCQTGTDLVIGVSKSHLAGHATPLPFNGLTKVPTYYVLAGEKPHDVAALSPAYGVDDECARLQGALAGAEVAWRAVAEACGTLYSTVHLGSLTSSKVVRDDYLQAARPISEQVAAQLRAFAQAPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K600</accession>
    <name>A0A2H3K600_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_104321</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468146">
        <property type="protein sequence ID" value="PCH43857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OMA" id="MATCIWQ"/>
    <dbReference type="OrthoDB" id="2140489at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
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    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36986">
        <property type="entry name" value="UPF0643 PROTEIN PB2B2.08"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36986:SF1">
        <property type="entry name" value="UPF0643 PROTEIN PB2B2.08"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH43857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="305" mass="33964" checksum="21A2F101B882F2F1" modified="2018-01-31" version="1">MVATFHLPSPIESCSNILDSVMLYKPRTVGMLYPSHSTSPQSSSFKMGSVTVLPARILPEVHSADVSTSYTTASLATAAQVAIETTERDPEQRPVFLPGLAHSSPILYLPPILSTLPIGLIHNPPPTLPPSKDAVPLYTDSCLPTIDNASMALHRALYNFRPITPKYAAVPYPEAFNWNEFELPDSIEHEWYCVVFRSKRRDGSDSDPLYEADRQAHEEAVSNGGLILYWYGVPDPETRMNLATCIWHSRAHAVAATNNPRHARAMRLTAASYEHYELKRYLLCKVRGERGVTVKPYTDERAASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K610</accession>
    <name>A0A2H3K610_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycopeptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_40810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468146">
        <property type="protein sequence ID" value="PCH43867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K610"/>
    <dbReference type="STRING" id="742152.A0A2H3K610"/>
    <dbReference type="OMA" id="GANCADA"/>
    <dbReference type="OrthoDB" id="3342934at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013776521" evidence="1">
        <location>
            <begin position="21"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH43867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="161" mass="16682" checksum="35F1C033ED8FB817" modified="2018-01-31" version="1" fragment="single">MSFTLLTGLVAATLFATASAETHTIRFNNQCGYGTPQLVYNGAAVSTGQDYTVDGSFSGIAYLQTGDCGLNGEECLLLEMTLINPTVPGGGSSADISLIAPHAFNVQGSFSYFNGCNNTGANCADASCAAAFYQPDETEVQVACETDDVDLLIAFCADATQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K6M2</accession>
    <name>A0A2H3K6M2_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Arylalcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WOLCODRAFT_123011</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB468157">
        <property type="protein sequence ID" value="PCH44087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K6M2"/>
    <dbReference type="STRING" id="742152.A0A2H3K6M2"/>
    <dbReference type="OMA" id="NSNFPAW"/>
    <dbReference type="OrthoDB" id="48988at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF2">
        <property type="entry name" value="ARYL-ALCOHOL DEHYDROGENASE AAD10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="3">
        <location>
            <begin position="32"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PCH44087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="384" mass="43148" checksum="AAD1DB4EBEE8AD9E" modified="2018-01-31" version="1">MPRGVFDLAPEPPTKLGRHRQLAPIAGIHVSPICLGAMSIGDQWGSAGMGQMDRESSFKLLDAFYEAGGNFIDTANNYQEETSEKFIGEWMEARGVRDQMVIATKYTSNFKCIADIPQKTSYVGNGMKSLYVSVEASLKKLRTDYIDILYLHWWDWTCGVEEIMNGLHNLVTSRKVLYLGISDTPAWIVSKANMYARLTGKTPFVIYQGKWSILTRDFEREIIPMARSEGMALAPWEVLAGGRIRTDAEEERRRQTGEKGRMILSPEWERTPDERKVCQALEKVAAEVSAKSITSVAIAYVMQKAPYVFPIIGGRKVEHLMDNIEALNIALSPEQITYLESVLPFDAGFPYGMIGNGLDYNPFHRTAGQFEKWPTQQAIRPSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K6Y1</accession>
    <name>A0A2H3K6Y1_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aldehyde dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WOLCODRAFT_139274</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3 6">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468168">
        <property type="protein sequence ID" value="PCH44824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K6Y1"/>
    <dbReference type="STRING" id="742152.A0A2H3K6Y1"/>
    <dbReference type="OMA" id="KMFGDNP"/>
    <dbReference type="OrthoDB" id="440325at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006081">
        <property type="term" value="P:aldehyde metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000004">
        <property type="entry name" value="Aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012394">
        <property type="entry name" value="Aldehyde_DH_NAD(P)"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570:SF16">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE TYPE III, ISOFORM Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036492">
        <property type="entry name" value="ALDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="8">
        <location>
            <begin position="9"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="active site" evidence="4 5">
        <location>
            <position position="236"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR036492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR036492-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PCH44824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="493" mass="53957" checksum="E6C84A69E1296B85" modified="2018-01-31" version="1">MMGSSTSSQTTAPNGSASAPAVRHNTLEEIDEIYARLTSTFRAGTTRPLAYRRAQLLQLARMLKENLGAFEDAFFQDLGKPRQEVGAMEVGNVLSACLYAAEHLEGWTKPEKPEVEEWRASWDATIYRVPKGVVLIIGPWNYPSILTLGPLVGAIAAGCTCVIKGSELVPALATLLASLLPRYLDSAAYAWVNGAVPETRHLLARRWDHVLFTGSGKTGRIVARTAAEYVTPVTLELGGKSPVVIAEDADIEIAAKRVLFGKAQNSGQLCVSPDHVYVPRALQDAFTAALLTAYRAFWPQGPLHPDAKWGKIVNPAHHARLRRLLERSKGTVVIGGEFDGETRIAPTIVRDVKLDDALMEEELFGPILPIIPVESVDEALEHIRSQPSPLVIYAFTSSEELKQRLLDTTYSGTLVLNDTTSQLAVYEMPFGGEGDSGHGRWYGKYSFDTFTNLRSFTNVPPAAEPFLGARYLPYTDESYAAMTSDLRLEIPDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K8K6</accession>
    <name>A0A2H3K8K6_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">26S proteasome regulatory subunit 8 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">WOLCODRAFT_139236</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468168">
        <property type="protein sequence ID" value="PCH44787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K8K6"/>
    <dbReference type="STRING" id="742152.A0A2H3K8K6"/>
    <dbReference type="OMA" id="REPAVIF"/>
    <dbReference type="OrthoDB" id="10255768at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19502">
        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000006">
        <property type="entry name" value="26S protease regulatory subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000044">
        <property type="entry name" value="26S protease regulatory subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000030">
        <property type="entry name" value="26S protease regulatory subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 14" id="KW-0647">Proteasome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="176"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="22"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PCH44787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="401" mass="44643" checksum="0CC9FDB3F15CD00B" modified="2018-01-31" version="1">MPVATHTPTHPGGIKAYYQAKIEAAEIDINQKTQNLRRLEAQRNALNARVRLLREELQLLHEPASYVGEVVKVMGKNRVLVKVQPEGKYIVDFDHTIDVASLKPSLRVALRSDSYTIHKILPNKVDPLVSLMMVEKVPDSTYEMVGGLDKQIKEIKEVIELPVKHPELFESLGIAQPKGVLLYGPPGTGKTLLARAVAHHTDCKFIRVSGSELVQKYIGEGSRMVRELFVMAREHAPSIIFMDEIDSIGSSRGESGSGGGDSEVQRTMLELLNQLDGFESTKNIKVIMATNRIDILDSALLRPGRIDRKIEFPPPGPEARVAILRIHSRKMSLQRGINLRALAEKMGQCSGAEVRGICTEAGMYALRERRQHVTQEDFEFAVAKVLKKNQEGNTSVNKLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K906</accession>
    <name>A0A2H3K906_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable quinone oxidoreductase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">NADPH:quinone reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WOLCODRAFT_27151</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468168">
        <property type="protein sequence ID" value="PCH44927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K906"/>
    <dbReference type="STRING" id="742152.A0A2H3K906"/>
    <dbReference type="OMA" id="CDHTIDY"/>
    <dbReference type="OrthoDB" id="48317at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003960">
        <property type="term" value="F:quinone reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05286">
        <property type="entry name" value="QOR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000053">
        <property type="entry name" value="Quinone oxidoreductase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047618">
        <property type="entry name" value="QOR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE PIG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106:SF13">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="5">
        <location>
            <begin position="16"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00043088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00070796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PCH44927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="342" mass="37162" checksum="F796909B6F658F6F" modified="2018-01-31" version="1">MQKASGFKAITISRTGDFDVIEKTDYPFPVSRDGNILIKVHYGGVNFIDTYYRKGLYRIDKFPFVIGSEGAGTIVQLPEDAEALAKDEEYQKRGFAHGGKVAFYQLGAFAEYVSIPWHKVFPVSESVSLKLAAAGLTQGLTAISFIDDAYNVQPGDVILVHTVAGGLGLLFAQLIKARGATVIGTTSTPEKAELARAHGADHVILYPVEDTVQRVLEITGGEGVHAVFDGVGKDTFENNFKVLRRKGTLVSVGNASGAVPPFPPLKLAEKNIRLLRPTMGNYVTTAEESRRYGTELFRLIESGELNINIHQEYPFSAEGVQQAQRDLTSGKTVGKLVVKIAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3ISU4</accession>
    <name>A0A2H3ISU4_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_159806</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH33056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3ISU4"/>
    <dbReference type="STRING" id="742152.A0A2H3ISU4"/>
    <dbReference type="OMA" id="TMANWAL"/>
    <dbReference type="OrthoDB" id="2953893at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="2">
        <location>
            <begin position="149"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH33056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="302" mass="33719" checksum="5FA507101640BAAB" modified="2018-01-31" version="1">MLFVWAFQGVLSVQIYMFHSFFPDERPLLKALVIGLYVFECVQTVLITVDTFDIYVYSHADYASVTAPLNLWFSSLIMNAMASVTVQWYFAWRLYIVSKSIVLLAGICFLAFIQAGAGFTSGIMQKEAPSLVNYRPVHPVTMVNLIGCALVDSIIAISMTVTLLRARSNVLAYRTPILNRIIRLGIGTGTLTASVAIVVLAMAFGSPQTFLFETLGFVISQFYVNSLVTNLNSRHFLRAEQQVVDISLRPSIWKVTDGRTHTLATTLRDPDYEAQPPTLCSTQGEVVSIQAPRLKIRRRFSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IT64</accession>
    <name>A0A2H3IT64_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Guanine nucleotide-binding protein alpha-2 subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WOLCODRAFT_111384</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD-104</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
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                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
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                <person name="Kuees U."/>
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                <person name="Kuo A."/>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Barry K."/>
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                <person name="Yadav J.S."/>
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                <person name="Gaskell J."/>
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                <person name="Larrondo L.F."/>
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                <person name="Nagy L.G."/>
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                <person name="Ohm R.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
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                <person name="Samejima M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007188">
        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000720">
        <property type="entry name" value="Guanine nucleotide-binding protein G(k) subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF360">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0807">Transducer</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="267"/>
            <end position="273"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="365"/>
            <end position="368"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PCH35936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="454" mass="51177" checksum="43B0A5042A58D3E4" modified="2018-01-31" version="1">MPSSPHRPQSDAEAIRINNQIDEDLKREHEQLKRRRPKEIKVMLLGQAESGKSTLQKQFQLYYSSQTLDHERPAWRPIVYFNILRAIRMILAELDYEYFSAQGTTAPTVAPSLSSSSGDSQSGPSTGYSSVDPAWIAELSQLRSKLLPLVASEDALASELSGGVTVTGGRTGVYVRAGWQALTTASRSWPLSDIRGTNGAKAPVMTDIVAKTLAANQDEIEDLWHHPGVRVLLATNKLRLEEYAAFFLDSIHRIAQPDYLPSTDDILHVRLQTLGVKEHVFDINMAGSNYTWLLYDVGGARGQRQAWVPYFEDATAVIFLAPISAFDQYLEEDARTNRIDDSLQLFTSICTNKLLQKAALVLMLNKTDLLKQKLAAGIKVRRYISSYGDRPNTYEEVSEYFRAHFMQVHRRKDVHRRPLYVHFTSMLDIKATQRIIVNVNEAIMKRHMATIGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J283</accession>
    <name>A0A2H3J283_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WOLCODRAFT_62340</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH33883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J283"/>
    <dbReference type="STRING" id="742152.A0A2H3J283"/>
    <dbReference type="OMA" id="AAYQMSQ"/>
    <dbReference type="OrthoDB" id="1393670at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107">
        <property type="entry name" value="NADPH-DEPENDENT ALDEHYDE REDUCTASE-LIKE PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107:SF26">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_4G05870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="83"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PCH33883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="300" mass="32753" checksum="CB25B46F313D57CB" modified="2018-01-31" version="1">MKFIEQFQKGYKPPFQEQPDAPGLREKLDPQPLNDVTADGKPYKAANKLGGQTAVITGADSGIGLSTAILFALEGADLTLTYTRREADEAKAAEEEIRRKTNNKRKIQMLEFDLRKEENCIELIKKHIAFHNGQLDALVLNHGTQYANTDLTTLPSEQWHNTFDTNIHAFFYICKAAIPHMKPGSTINFNASINMAIGHPELIDYTATKGAIIAFMRALSNQVVGDKGIRCNAVAPGAVWTPLIPATMTKSSIENFGVTAPMGRAGQPVEIATAFVWLASPDSSFMSGQVLHVNGGIVIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J2L3</accession>
    <name>A0A2H3J2L3_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Replication factor C subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WOLCODRAFT_94642</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH34013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J2L3"/>
    <dbReference type="STRING" id="742152.A0A2H3J2L3"/>
    <dbReference type="OMA" id="SCNYSSQ"/>
    <dbReference type="OrthoDB" id="4199794at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031391">
        <property type="term" value="C:Elg1 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031389">
        <property type="term" value="C:Rad17 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000012">
        <property type="entry name" value="Replication factor C subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000015">
        <property type="entry name" value="Replication factor C subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000107">
        <property type="entry name" value="Replication factor C subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013748">
        <property type="entry name" value="Rep_factorC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001679">
        <property type="entry name" value="PRK00440.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF5">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08542">
        <property type="entry name" value="Rep_fac_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="8">
        <location>
            <begin position="57"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00070186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PCH34013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="346" mass="38514" checksum="4FC534E7DCB32990" modified="2018-01-31" version="1">MASSSAKGKAPANGSNSDTPYELPWCVVEKYRPQVLDDIVGNSETIERLKVIAKDGNCPHIIISGMPGIGKTTSIHCLAHQLLGDAYKEGVLELNASDERGIDVVRNKIKAFAQKKVTLPPGRQKIVILDEADSMTPGAQQALRRTMEIYANTTRFALACNMSNKIIEPIQSRCAILRYAKLRDAEILKRLLEICDMEQVKYNDDGLTALIFTSEGDMRQAINNLQSTHSGFGFVSGDNVFKVCDQPHPIIVQTIMRACIKGDIDTAMEKLNELWDQGYSAVDIVVTIFRVVKTFDEIPEYTKLEYIKEIGFTHMRILEGVGTLIQLGGLMARLCKMNMKPELFKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J2U3</accession>
    <name>A0A2H3J2U3_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Acyl-CoA oxidase C-alpha1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_82207</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467876">
        <property type="protein sequence ID" value="PCH36486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J2U3"/>
    <dbReference type="STRING" id="742152.A0A2H3J2U3"/>
    <dbReference type="OMA" id="MTPKFWA"/>
    <dbReference type="OrthoDB" id="538336at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003997">
        <property type="term" value="F:acyl-CoA oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005504">
        <property type="term" value="F:fatty acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033540">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA oxidase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055060">
        <property type="entry name" value="ACOX_C_alpha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012258">
        <property type="entry name" value="Acyl-CoA_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909:SF382">
        <property type="entry name" value="ACYL-COENZYME A OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909">
        <property type="entry name" value="ELECTRON TRANSPORT OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22924">
        <property type="entry name" value="ACOX_C_alpha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA oxidase C-alpha1" evidence="1">
        <location>
            <begin position="263"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH36486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="572" mass="63404" checksum="1F7C6B42F465DB94" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J314</accession>
    <name>A0A2H3J314_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Phosphatidylserine decarboxylase proenzyme 1, mitochondrial</fullName>
            <ecNumber evidence="12">4.1.1.65</ecNumber>
        </recommendedName>
        <component>
            <recommendedName>
                <fullName evidence="12">Phosphatidylserine decarboxylase 1 beta chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="12">Phosphatidylserine decarboxylase 1 alpha chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="12" type="primary">PSD1</name>
        <name evidence="14" type="ORF">WOLCODRAFT_134947</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H(+) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CO2</text>
            <dbReference type="Rhea" id="RHEA:20828"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="EC" id="4.1.1.65"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
        <text evidence="12">Binds 1 pyruvoyl group covalently per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.</text>
    </comment>
    <comment type="subcellular location">
        <molecule>Phosphatidylserine decarboxylase 1 alpha chain</molecule>
        <subcellularLocation>
            <location evidence="12">Mitochondrion inner membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
            <orientation evidence="12">Intermembrane side</orientation>
        </subcellularLocation>
        <text evidence="12">Anchored to the mitochondrial inner membrane through its interaction with the integral membrane beta chain.</text>
    </comment>
    <comment type="subcellular location">
        <molecule>Phosphatidylserine decarboxylase 1 beta chain</molecule>
        <subcellularLocation>
            <location evidence="12">Mitochondrion inner membrane</location>
            <topology evidence="12">Single-pass membrane protein</topology>
            <orientation evidence="12">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="12">Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type I sub-subfamily.</text>
    </comment>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="entry name" value="PS_Dcarbxylase"/>
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        <property type="entry name" value="PSD-B"/>
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    </dbReference>
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        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE PROENZYME, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02666">
        <property type="entry name" value="PS_Dcarbxylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8 12" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="11 12" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="12" id="KW-0865">Zymogen</keyword>
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        <location>
            <begin position="1"/>
            <end position="502"/>
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        <location>
            <begin position="503"/>
            <end position="541"/>
        </location>
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        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="topological domain" description="Mitochondrial intermembrane" evidence="12">
        <location>
            <begin position="99"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="275"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="284"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="12">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="12">
        <location>
            <position position="388"/>
        </location>
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    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="12">
        <location>
            <position position="503"/>
        </location>
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    <feature type="active site" description="Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity" evidence="12">
        <location>
            <position position="503"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage (non-hydrolytic); by autocatalysis" evidence="12">
        <location>
            <begin position="502"/>
            <end position="503"/>
        </location>
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    <feature type="modified residue" description="Pyruvic acid (Ser); by autocatalysis" evidence="12">
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            <position position="503"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
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        <source>
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        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH33129.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="541" mass="59983" checksum="84213E4F1BE371A0" modified="2018-01-31" version="1"> </sequence>
</entry>
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        </lineage>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
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                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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    </evidence>
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    </evidence>
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</entry>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
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                <person name="Martinez A.T."/>
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                <person name="Nagy L.G."/>
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                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
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                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="207"/>
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        </location>
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        <location>
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        </location>
    </feature>
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        </location>
    </feature>
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    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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        </location>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH34039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="566" mass="60209" checksum="EE38BA78B2B3A466" modified="2018-01-31" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J5N8</accession>
    <name>A0A2H3J5N8_WOLCO</name>
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        <submittedName>
            <fullName evidence="8">WLM-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WOLCODRAFT_87248</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD-104</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
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        <location>
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            <end position="207"/>
        </location>
    </feature>
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        <location>
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            <end position="331"/>
        </location>
    </feature>
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        </location>
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        <location>
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        </location>
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        <location>
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        </location>
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        <source>
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        </source>
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        </source>
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    </evidence>
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        <source>
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        </source>
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</entry>
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    <accession>A0A2H3J5Q8</accession>
    <name>A0A2H3J5Q8_WOLCO</name>
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        <recommendedName>
            <fullName evidence="11">ATP synthase F(0) complex subunit e, mitochondrial</fullName>
        </recommendedName>
    </protein>
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        <name evidence="12" type="ORF">WOLCODRAFT_135497</name>
    </gene>
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        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Subunit e, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro. Part of the complex F(0) domain.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) and CF(0) have multiple subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ATPase e subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH34089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="ATP_synth_F0_esu_mt"/>
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        <property type="entry name" value="ATP-synt_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="4 11" id="KW-0138">CF(0)</keyword>
    <keyword evidence="5 11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
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        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PCH34089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="89" mass="10216" checksum="4542FB819CABEAD5" modified="2018-01-31" version="1">MASSTVNVVRYTALLTGAFYGITHRRTLQKAHDEEKEHHAIHEREHLIAQAKEAWKKKQEGSKDGVVTDPDDPRFDLEKLFAKWESEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J679</accession>
    <name>A0A2H3J679_WOLCO</name>
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        <submittedName>
            <fullName evidence="11">Cytochrome P450 monooxygenase pc-3</fullName>
        </submittedName>
    </protein>
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        <name evidence="11" type="ORF">WOLCODRAFT_22844</name>
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        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD-104</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
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        <property type="protein sequence ID" value="PCH37762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11063">
        <property type="entry name" value="CYP52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047146">
        <property type="entry name" value="Cyt_P450_E_CYP52_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287:SF1">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
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        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9 11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="40"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="523"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PCH37762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="607" mass="69736" checksum="DBFE4DD78245403D" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J6B3</accession>
    <name>A0A2H3J6B3_WOLCO</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
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            <taxon>Phaeolaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
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                <person name="Martin F."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH33198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J6B3"/>
    <dbReference type="Proteomes" id="UP000218811">
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH33198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="105" mass="10954" checksum="345826276AAE708B" modified="2018-01-31" version="1">MQVATASTHMMHAGGAGDRARQLDGEGRSGGVEGESAIQMGSADGGRGRARGDATSAYKEMVPCDRCFRMEVRGASGQRTADPPSPARPPHDMLARPFKANTALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J6D4</accession>
    <name>A0A2H3J6D4_WOLCO</name>
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        <submittedName>
            <fullName evidence="3">DUF382-domain-containing protein</fullName>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
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                <person name="Lindquist E."/>
                <person name="Ling A."/>
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                <person name="Lucas S."/>
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                <person name="Martin R."/>
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                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH37822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="742152.A0A2H3J6D4"/>
    <dbReference type="OMA" id="KGEPIGQ"/>
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    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="DUF382"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006568">
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
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                <person name="Sabat G."/>
                <person name="Salamov A."/>
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                <person name="Stenlid J."/>
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                <person name="Syed K."/>
                <person name="Tsang A."/>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
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                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
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                <person name="Kumar T.K.A."/>
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                <person name="Lindquist E."/>
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                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
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                <person name="Ohm R.A."/>
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                <person name="Sabat G."/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <feature type="disulfide bond" evidence="1">
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    </feature>
    <feature type="disulfide bond" evidence="1">
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        </location>
    </feature>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="249" mass="26417" checksum="F137EEE66156E49D" modified="2018-01-31" version="1">MLAVLSVRTCARTFTVANDCPYTIWPAMFTGPSPKRAVPNYPAGWEAQPHTSVGFSVPNDWTAGRIWGRTDCDFSNDSASGQTCLTGWCIGGLLCNPTTGTGVPPATVAEWTLQGDNNKDYYDVSLVDGFNIPMEITNNAKCSTAECPADLNSLCPSALKGPSNSTGGVVGCQSSCDANLNDDKTNSPDCCTGSYSTAATCPSSGVQYYSFFKDNCPDSYAYAFDESSGTALWQCDSALNADYTLTFCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J7E4</accession>
    <name>A0A2H3J7E4_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Glutamate synthase [NADH]</fullName>
            <ecNumber evidence="19">1.4.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">WOLCODRAFT_23115</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27 28">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="21">Forms L-glutamate from L-glutamine and 2-oxoglutarate. Represents an alternative pathway to L-glutamate dehydrogenase for the biosynthesis of L-glutamate. Participates with glutamine synthetase in ammonia assimilation processes. The enzyme is specific for NADH, L-glutamine and 2-oxoglutarate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>2 L-glutamate + NAD(+) = L-glutamine + 2-oxoglutarate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13753"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="1.4.1.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="24">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
        <text evidence="24">Binds 1 [3Fe-4S] cluster.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-glutamate biosynthesis via GLT pathway; L-glutamate from 2-oxoglutarate and L-glutamine (NAD(+) route): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Energy metabolism; nitrogen metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Nitrogen metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glutamate synthase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.14" evidence="19"/>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH38146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="742152.A0A2H3J7E4"/>
    <dbReference type="OMA" id="WDGPAAM"/>
    <dbReference type="OrthoDB" id="4327079at2759"/>
    <dbReference type="UniPathway" id="UPA00045"/>
    <dbReference type="UniPathway" id="UPA00634">
        <property type="reaction ID" value="UER00690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016040">
        <property type="term" value="F:glutamate synthase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016639">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019676">
        <property type="term" value="P:ammonia assimilation cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097054">
        <property type="term" value="P:L-glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00982">
        <property type="entry name" value="gltB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00713">
        <property type="entry name" value="GltS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02808">
        <property type="entry name" value="GltS_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1060.10:FF:000006">
        <property type="entry name" value="Glutamate synthase (NADPH/NADH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000031">
        <property type="entry name" value="Glutamate synthase 1 [NADH]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000017">
        <property type="entry name" value="Glutamate synthase [NADH], amyloplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000113">
        <property type="entry name" value="Glutamate synthase [NADH], amyloplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000022">
        <property type="entry name" value="Glutamate synthase [NADH], amyloplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.60:FF:000001">
        <property type="entry name" value="Glutamate synthase, large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000001">
        <property type="entry name" value="Glutamate synthase, large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="entry name" value="Alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.60">
        <property type="entry name" value="Glutamate synthase, alpha subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028261">
        <property type="entry name" value="DPD_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002489">
        <property type="entry name" value="Glu_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036485">
        <property type="entry name" value="Glu_synth_asu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006982">
        <property type="entry name" value="Glu_synth_centr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012220">
        <property type="entry name" value="Glu_synth_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002932">
        <property type="entry name" value="Glu_synthdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006005">
        <property type="entry name" value="Glut_synth_ssu1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051394">
        <property type="entry name" value="Glutamate_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01317">
        <property type="entry name" value="GOGAT_sm_gam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008730">
        <property type="entry name" value="PRK11750.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43100">
        <property type="entry name" value="GLUTAMATE SYNTHASE [NADPH] SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43100:SF1">
        <property type="entry name" value="GLUTAMATE SYNTHASE [NADPH] SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14691">
        <property type="entry name" value="Fer4_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00310">
        <property type="entry name" value="GATase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04898">
        <property type="entry name" value="Glu_syn_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01645">
        <property type="entry name" value="Glu_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01493">
        <property type="entry name" value="GXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000187">
        <property type="entry name" value="GOGAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69336">
        <property type="entry name" value="Alpha subunit of glutamate synthase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46548">
        <property type="entry name" value="alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="18 24" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0274">FAD</keyword>
    <keyword evidence="9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0288">FMN</keyword>
    <keyword evidence="17" id="KW-0314">Glutamate biosynthesis</keyword>
    <keyword evidence="13" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="15" id="KW-0408">Iron</keyword>
    <keyword evidence="16 24" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="26">
        <location>
            <begin position="59"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="25">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="23">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="1187"/>
        </location>
        <ligand>
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="1193"/>
        </location>
        <ligand>
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="1198"/>
        </location>
        <ligand>
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00024383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00057049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00068518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PIRSR" id="PIRSR000187-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PIRSR" id="PIRSR000187-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="PCH38146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="2151" mass="236832" checksum="4F8528EE8B3D5689" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J856</accession>
    <name>A0A2H3J856_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphatidylinositol N-acetylglucosaminyltransferase subunit H conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WOLCODRAFT_96527</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD-104</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PIGH family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH38121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J856"/>
    <dbReference type="STRING" id="742152.A0A2H3J856"/>
    <dbReference type="OMA" id="NEGLHGW"/>
    <dbReference type="OrthoDB" id="6256716at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000506">
        <property type="term" value="C:glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044215">
        <property type="entry name" value="PIG-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019328">
        <property type="entry name" value="PIGH-H_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15231">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15231:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10181">
        <property type="entry name" value="PIG-H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphatidylinositol N-acetylglucosaminyltransferase subunit H conserved" evidence="3">
        <location>
            <begin position="92"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PCH38121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="197" mass="22526" checksum="5B344F5F103F8DB4" modified="2018-01-31" version="1">MRRDLPLLDHPELTLIECPAWLEYRVDNPRFLPDGPNGSEATVAFFWLDAFVPLVIATLWPLPSRSPGTLACLFVLLAIYLYARCTQVLWESVVILPSLGLQLETHRGPPRIPLFVSRRFIPLSTLQDFIINEGLHGWDVRYYLAAIQQSRTGAVSLEVAYENLLPRFPVLLEVYYAVHEKLLNNGSNTDVHDEYHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J8H8</accession>
    <name>A0A2H3J8H8_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_64409</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH38562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J8H8"/>
    <dbReference type="STRING" id="742152.A0A2H3J8H8"/>
    <dbReference type="OMA" id="EQNFDAP"/>
    <dbReference type="OrthoDB" id="3647at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861:SF3">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G14390)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH38562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="182" mass="20019" checksum="78CEB6758FB0CDAE" modified="2018-01-31" version="1">MAALFQEDATDMMEYACGTGLVSRELCAYVRSIVGIDISEGMVEQFNLRARNQGLDRDEMQAFCVELKGNEEELDGRKFDLIVCSLSYHHFSSIEDITRILAFFLKPGGSLLVADIMKSTIEGDIFPGNTDVVAHQRGFSEEEMRGVFEEAGLADVTYMLATSGTSHGKPVDLFLACGVKPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J8I8</accession>
    <name>A0A2H3J8I8_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Endonuclease III homolog</fullName>
            <ecNumber evidence="12">3.2.2.-</ecNumber>
            <ecNumber evidence="12">4.2.99.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Bifunctional DNA N-glycosylase/DNA-(apurinic or apyrimidinic site) lyase</fullName>
            <shortName evidence="12">DNA glycosylase/AP lyase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">NTH1</name>
        <name evidence="15" type="ORF">WOLCODRAFT_136330</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the Nth/MutY family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.-" evidence="12"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HHH"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 12" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="14">
        <location>
            <begin position="155"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="30"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="334"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="68"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="82"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
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        <source>
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        </source>
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            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH38540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="390" mass="42681" checksum="CF4F632260BC8A46" modified="2018-01-31" version="1">MPSLKRSASPVLEARPSPYHPSVTLFAATASAAHDAQSSPRRSRRLVDNHVRRATASATDIEEETASPRKTSGRATSGSPTKRTRSASPRKPKPVPQALETPHPAPPRWREAYDAIKEMRSQIVAPVDTMGAGAAQLGETVPENKRFATLISLMLSSQTKDEVTSAAVVKLREAVGGSLSVDAILRADDSVISNAICKVGFWRRKTEYIKQTAQRLHDEFNSDVPKTVDELCSLPGVGPKMAFLTLHVAWKINAGIGVDVHVHRITNRLKWHQAPTKTPEETRLNLQSWLPTELRPTFTRLLVGFGQTICLPTNPRCDQCSLSSGLCPSVLKTPRRSGKLAGSDTQRKGAKGSHTGPKLEISIDEDKLLPPARKIEREAIMELTLKQEDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J8N5</accession>
    <name>A0A2H3J8N5_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cerato-platanin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WOLCODRAFT_23456</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cerato-platanin family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH38580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="entry name" value="DPBB_CEPL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cerato-platanin"/>
    </dbReference>
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        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
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        <property type="entry name" value="Cerato-platanin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013763106" evidence="4">
        <location>
            <begin position="21"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PCH38580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="144" mass="14778" checksum="F7275AC8F83A1007" modified="2018-01-31" version="1">MQFAALAAALALVCAPSVLSQTTVSVSYDEAYDNSAASLDTVSCSDGVYGLESYGYTTFGSLPDFPYIGGAVAVSGWGSAECGTCWNLTYGEYTISVLAIDHASPGFNIALEAMNVLTNNQATFLGRVNATATQVDASVCGLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J8P1</accession>
    <name>A0A2H3J8P1_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WOLCODRAFT_159789</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH33034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J8P1"/>
    <dbReference type="STRING" id="742152.A0A2H3J8P1"/>
    <dbReference type="OMA" id="YDIATIQ"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03228">
        <property type="entry name" value="ABCC_MRP_Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221:SF654">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B MEMBER 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="4">
        <location>
            <begin position="277"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PCH33034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="417" mass="45906" checksum="F7A42C824DBB7323" modified="2018-01-31" version="1">MVQRQLDAAGNITSFGGIAWGLIRMGTSVFSGACQVLSQGSVLLATLQGQLDGPLLATLCIIQTVVDIWSITNKYNWHNKGVWAATTANNDYIRVEGLKRIVGSKEYRKELVAGNLADYCISGFRNAIERVGTVTGDFASVMREYQERDGLTLLSLLREPWQELPQIIFTIRAVQYPASVPVSLASLHLIQQTTSDFGFTMFRFMDNFGSIAEQLSKVRNLYDIATIQNRVQDGTVPFPEDTEKLKSGIAIEFRNVSFRYPETDKDVLRNVSFKVSPGQLCVIVGANGSGKSTILKLIVRLYDVQGGMILVNGQDIRMLKLAGLRQAISVLFQDYTHFPLSIRENIALGKPSMQQAKKEFGQLHGLGVPRSSLISYPTASTHTSTAPSKIIIQTSQKELACFLVEKSTIVPCVASEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J8T6</accession>
    <name>A0A2H3J8T6_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_28384</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467876">
        <property type="protein sequence ID" value="PCH36213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J8T6"/>
    <dbReference type="STRING" id="742152.A0A2H3J8T6"/>
    <dbReference type="OMA" id="HIYLDFR"/>
    <dbReference type="OrthoDB" id="5429442at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH36213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="985" mass="110405" checksum="02DE997BD4C59E9B" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J958</accession>
    <name>A0A2H3J958_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DHS-like NAD/FAD-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WOLCODRAFT_157048</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KB467876">
        <property type="protein sequence ID" value="PCH36333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J958"/>
    <dbReference type="STRING" id="742152.A0A2H3J958"/>
    <dbReference type="OMA" id="RRHYWAR"/>
    <dbReference type="OrthoDB" id="424302at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF10">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="7">
        <location>
            <begin position="20"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PCH36333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="362" mass="39825" checksum="29F9E8E523A0BC99" modified="2018-01-31" version="1">MRISVPTIPDALLRTASASQTISPRAAAERVAEFLAPGNVAVLTGAGVSVDSGIRAYRGAKGRYLNPNYKPIFYHELMDETAKGAAYRRRYWLRSYIGYPPVRDALPNTTHYAFAALQYKSVVNKLITQNVDGLHHKAIAHVWSDTQMQDHIVELHGQLRSVRCLRGHLIDRDEFQQHLSAANPEWKAFMDDLEATGAQPRTNPDGDVVLGEGVRYDDFVVPDCPTCLAEGIHNNVQKPEVTFFGESISKEIKDRSYHDVEECDRLFMAGTTLATFSAFRLLKHALQLGKPVLLLNVGPTRADGLPEVEKIEIPSGSIMREVVKAVLGSAHATDPVVGGMLQRGIVKPPPEDEDDAAPRAVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J9B4</accession>
    <name>A0A2H3J9B4_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Actin-binding FH2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WOLCODRAFT_136453</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
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                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
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                <person name="Lindquist E."/>
                <person name="Ling A."/>
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                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
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                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
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                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
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                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
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                <person name="Young D."/>
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</entry>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
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                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
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                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
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                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
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                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
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                <person name="Martin R."/>
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                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
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            <dbReference type="DOI" id="10.1126/science.1221748"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">MD-104</strain>
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        </source>
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</entry>
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        <recommendedName>
            <fullName evidence="3">Ricin B lectin domain-containing protein</fullName>
        </recommendedName>
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    <reference evidence="1 2" key="1">
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            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
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                <person name="Benoit I."/>
                <person name="Boyd A."/>
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                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
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                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
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                <person name="Kumar T.K.A."/>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="APC4"/>
    </dbReference>
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        <property type="entry name" value="Apc4-like_WD40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024790">
        <property type="entry name" value="APC4_long_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
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    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13260">
        <property type="entry name" value="ANAPHASE PROMOTING COMPLEX SUBUNIT 4 APC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13260:SF0">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12896">
        <property type="entry name" value="ANAPC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12894">
        <property type="entry name" value="ANAPC4_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="BZIP" evidence="8">
        <location>
            <begin position="845"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1044"/>
            <end position="1069"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1100"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
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            <begin position="1149"/>
            <end position="1173"/>
        </location>
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            <begin position="1191"/>
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            <begin position="864"/>
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            <begin position="207"/>
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        </location>
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            <begin position="1051"/>
            <end position="1069"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1108"/>
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        </location>
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        <location>
            <begin position="1196"/>
            <end position="1205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00016067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PCH33624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="1307" mass="143688" checksum="03636C25C182B4CB" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JAT0</accession>
    <name>A0A2H3JAT0_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_159599</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF2">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="215"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH39306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="418" mass="47932" checksum="6CC4BEB6FA592F6A" modified="2018-01-31" version="1">MFLAGIIPGPSKPSLHEINHLLRPLIDDLLGCWEPGIWYTRTPTYPDGRRARCAAIPLVCDLPAARQMAGFAGFSCLKFFCSFFQLHLDNIDDINRSTWGHRDHADHRHWAMKWRDAESEREREEIFESHGIRYSKLLRLPYWDPTTFTILDTMHAMFLNNLKRHCRTIWGMDVKFQDGDGTEIEPNVRSTNTTPTDADMKDAVRIFREGSNTALQCLPKSTLRVLARDKGLKYSGWKERLVKRLLDYRVSTGWFSEDGRLLVKAKDGELPKVAEVHASTDMDEEQLHIALDFLEAAHSTQSLLEPTKRTLVELCMNKWPDQQRDTLQRRNKKQLCELLADWRLQQGLTSPSGELIVPNSGRLAAARKARSTVKRAKVLGRDRLRAVWDDMELTVLPTWLPPAPHHIGDGRHGKISAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JAU2</accession>
    <name>A0A2H3JAU2_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Gamma-butyrobetaine hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WOLCODRAFT_167216</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD-104</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the gamma-BBH/TMLD family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467898">
        <property type="protein sequence ID" value="PCH36933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JAU2"/>
    <dbReference type="STRING" id="742152.A0A2H3JAU2"/>
    <dbReference type="OMA" id="VHITWPN"/>
    <dbReference type="OrthoDB" id="406634at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045329">
        <property type="term" value="P:carnitine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00250">
        <property type="entry name" value="CAS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050411">
        <property type="entry name" value="AlphaKG_dependent_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010376">
        <property type="entry name" value="GBBH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696">
        <property type="entry name" value="GAMMA-BUTYROBETAINE HYDROXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696:SF25">
        <property type="entry name" value="OXIDOREDUCTASE AIM17-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06155">
        <property type="entry name" value="GBBH-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma-butyrobetaine hydroxylase-like N-terminal" evidence="8">
        <location>
            <begin position="40"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="TauD/TfdA-like" evidence="7">
        <location>
            <begin position="149"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF06155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PCH36933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="414" mass="46662" checksum="1CE0B85D6FAB16C6" modified="2018-01-31" version="1">MVLFRPASLCTRPYARLSSTSIPSRSGTTPLPGLSYQGLSLPYRWLRDSCQCPQCVHPSTRQKLHRTSDIPEDIHPAADGVRFAEGGMRILWSSGHDSHYTREFLERYSLQQQLRAFHRDVDLEYWDVAELKAAHNLYLPYSSLQAPSGLLAAITQLTRYGLLFVTNVPNEKTSDTECELRRLAARFGELRETFYGTTWDVKNVRNSRNVAYTNIDLGLHMDLLYFQHPPRFQILHCLRNRVVGGTSIFVDAFHAASKLRAADPAAFQTLAETPVAFHYINDGHHLHYAHPTIQLAALPSPGADPRAPRPIAHVNYSPPFQAPLPLDTPAAFYPALARFVALLEDPAAQYEYTLREGDAVLFDNRRVLHARTAFTDREDPGDGGADATNRWLKGCYLEADAVLDRGRVLREQLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JAU4</accession>
    <name>A0A2H3JAU4_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_141071</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467954">
        <property type="protein sequence ID" value="PCH39031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JAU4"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH39031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="74" mass="7738" checksum="09D85C70F43E1198" modified="2018-01-31" version="1">MASSQPSHKLAATGDAEHGRSDRFCRPVAGDSTSSRSRPEIGGGKMLTIRIAHLLARRCPTGSALCSGKRSGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JAW7</accession>
    <name>A0A2H3JAW7_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_141248</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467987">
        <property type="protein sequence ID" value="PCH39402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JAW7"/>
    <dbReference type="STRING" id="742152.A0A2H3JAW7"/>
    <dbReference type="OMA" id="IPRAGEC"/>
    <dbReference type="OrthoDB" id="2744000at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH39402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="278" mass="30682" checksum="1EC2628DB67F61BC" modified="2018-01-31" version="1">MPTSTPAPRTMLRSHEPSGSSSISDAFYALEDPGGSGVEEPASSPGTVTLTARQFTQLLSLIQLSPNSSLVPELAVPPSPISPRRPVQKMRSTSSPLLHTSVTAPSFPTFNAGPIPRAGECVLGKSLLESFPHVQAEVLLNIARHTFEPRDLCKLDMHFSDRVPRTCPSNPSPTSYEFITHFYPSFSSLFVPLSTYFRILLAHAASSGNIDATYNLASASDEYLAHLVCLHEEYHWSVVLQYHMRFHAARMQEMCRGEYTGWAHADLPLLMQILDENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JAY1</accession>
    <name>A0A2H3JAY1_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_141822</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH33824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JAY1"/>
    <dbReference type="STRING" id="742152.A0A2H3JAY1"/>
    <dbReference type="OMA" id="YRQHLHP"/>
    <dbReference type="OrthoDB" id="420422at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033063">
        <property type="term" value="C:Rad51B-Rad51C-Rad51D-XRCC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005657">
        <property type="term" value="C:replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000400">
        <property type="term" value="F:four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042148">
        <property type="term" value="P:DNA strand invasion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19490">
        <property type="entry name" value="XRCC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030547">
        <property type="entry name" value="XRCC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46644">
        <property type="entry name" value="DNA REPAIR PROTEIN XRCC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46644:SF2">
        <property type="entry name" value="DNA REPAIR PROTEIN XRCC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH33824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="407" mass="44301" checksum="EF211DCE6244D641" modified="2018-01-31" version="1">MDTALPGITVDALLNEVHTESLQNVLVAVRRHTSGIGDVNIPALDEHLSSHLSASFPAKSSMNRGDVIEIQGPPASGKSQLLHHLLIGCITPTHYGSTAIYGWDKAAVLFDTDGTFDAERFNRLLVSRLSRMIGIQNQSDVPGAFVQPASFPIEKLASRCLARLHVFRPDSSYQLAATLMHLPRYHATHSSLRSAEIGLVAIDSMSAFHWTDRFTMEQLRGAHEATGAAKNSAAESLAPLQCVMMALQALRASHGPVIAFTNWGLHPMTNSAPTGEPASQFYRQHLHPYPAAFERPLATSASPALRSVAVPPATSLHSPEAEFQQLQSAAVDRLLLTHHITLHPLHVEAFPARFGLGDVKREDSLRCHLVQRGEIHGFIRTPGTADIGKFSFFINDEDILAETPSVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JB44</accession>
    <name>A0A2H3JB44_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6593 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_140146</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="PCH35969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="3242031at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="DUF6593"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6593" evidence="1">
        <location>
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            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH35969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="180" mass="20142" checksum="F59AC86C97828193" modified="2018-01-31" version="1">MTQFGMPFFLEDQTGELTGSEFVDLYNRMRLGFRCTLRDTHRTAYMVYDLSSRRASAAPLACLDFGANNALGTIKIGDGENISMAEYLSKASAGGKKARKFTASDGQQYRWVYQSTEDTEWMCLNSSDYHVASYSLKPAGEPHYSGSSGCMLTVEEQYPHIVGELLASLIIMRHIVKYNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JB77</accession>
    <name>A0A2H3JB77_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Alcohol dehydrogenase GroES domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WOLCODRAFT_158382</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Phaeolaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD-104</strain>
        </source>
    </reference>
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            <name>Zn(2+)</name>
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        </cofactor>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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        <property type="entry name" value="ADH-like_N"/>
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        <property type="entry name" value="ADH_Zn_CS"/>
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    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813:SF4">
        <property type="entry name" value="NADP-DEPENDENT ISOPROPANOL DEHYDROGENASE"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="8">
        <location>
            <begin position="28"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="7">
        <location>
            <begin position="171"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH38845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="321" mass="34028" checksum="1638DFFFDF93C60F" modified="2018-01-31" version="1">MATMKALAYLGKGEIGVVERPKPAIQFPTDAVVKLLKTTICGTDLHIMKGDVPTVPEGRILGHEGIGTIESAGSSVISLVPGDLVVISCITACGTCNFCRRGITSHCTSGGWILGNTVDGTQAEYVRVQFANTSLYHAPKGVDLNALVMTSDILPTSLECGVLSDSPRLLIAMDVDGNRLEAARKHGATHTVRSGPNAVKEVMDITGGLGVDSAIEAVGIPATFELCQDLVGVGETIANVGVHGSKVDLHLEELWDRNVAITARLVDAVTTPTLLQMLESGRLDATPLITHHFRFSEIMESYTTFKAAAENKALKVIIDFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467943">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OMA" id="RMHDYSI"/>
    <dbReference type="OrthoDB" id="2152896at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="383"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
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            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
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        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="397"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PCH38965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="471" mass="48409" checksum="801BB5DA5A86B3C1" modified="2018-01-31" version="1">MSHAGGSVASNEAEGLLSLSLAAASAVPIPVAWDSGHEIASGSYNGPSSFSGGGSSVGASSKIHLAHRNRRVASTGHVRRKLSDAREAASRPSPVTISSAAAALTSLAKLSLSGTPPPQTSTTLVSASGTVSSGKQVKEEDVEPANADLSGTGISIENGKGTGKRRGTIFKCESCSKVYKHPSCLIKHRWEHSPHWREASKFLLSKHQQVQLLEAAAILSHLSPSAQGGTSLPEDRSLWPSFLSGGLLPPPDPANTVNAKGTASTIPLAQPAPFRASSSVPALSVLSSSARSGPRMHDYAVPATGGITQLRPGVLGVPTGSSTPAPAPAPTSTAPVPIVPVPVPALRREESASVVSDAWSSPVSVSFAPSSLRSSSVSASALGRSYSDGTGGWSLPRSSVRSESGSRSRSGSVEDDFVDVDGVDDYYGYKAGGGYGFSVRSGSYASDKGMAVDVGHEKIEEEWDGEMEMEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JBL4</accession>
    <name>A0A2H3JBL4_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_133703</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467843">
        <property type="protein sequence ID" value="PCH35058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JBL4"/>
    <dbReference type="OMA" id="MNAALIC"/>
    <dbReference type="OrthoDB" id="2797145at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="AntiFam" id="ANF00062">
        <property type="entry name" value="Shadow ORF (opposite ABC transporter protein)"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH35058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="150" mass="16476" checksum="FC006740A9D7DA1E" modified="2018-01-31" version="1">MATRCSSPPESVFTSWSRMGSRFMGFTTSVLNCGCINDALIRFNSSMRTVPGNDGEIVCGLSETESVCLSVSSSGVSPASRRMNVVLPIPFSPSITMISESWRVLSMISSSAVSTILKVSESSRNRRFSVGMKPSRKMQKDRRYKPSRTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JBT0</accession>
    <name>A0A2H3JBT0_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_29500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467987">
        <property type="protein sequence ID" value="PCH39361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JBT0"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="116"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH39361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="138" mass="14505" checksum="BB0E1EC8657FD6BD" modified="2018-01-31" version="1">MATVLGLGATCSLHRGGASVARLIDVPGRLPAAGSRSTSCSHSLSGLHRYLCDGDGDQYCGRASRRRPRSPVLPGRTSKPPTESTRCVRRAIARPNAAHSQVTPAEPLDPPNPGASSSYITSTCPSSQAQQRAEVPRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JBT9</accession>
    <name>A0A2H3JBT9_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_159240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468031">
        <property type="protein sequence ID" value="PCH39656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JBT9"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH39656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="283" mass="31290" checksum="C76BAD64F234F528" modified="2018-01-31" version="1">MILIIGSSYPHSGQSASLCALAIALVSSSLHLLVWGLLGTPALVVITLSKPRVFYTGVRSDAAGQRLAQAPPSTQLSAPTKRRRRHTLWNEERRDPSQEDPPQGAQPAKAALPYGAPSPKTVQLPISRVKAPPPSSSLRRVAMMAARPWERRLPHQPLTTATTSRPPPASPYRRRQLLSTALTLLESQQLSQRPHRRSLTGRHLRRAAISAACLRSGDSLNRPTRPRHRTVHAQPPATTAYPNRSPIPPSRHPRLARMERRLPKPSITALPHRTPLPARYLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JC49</accession>
    <name>A0A2H3JC49_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Phosphatidylserine synthase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">WOLCODRAFT_97860</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
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                <person name="Benoit I."/>
                <person name="Boyd A."/>
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                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
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                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
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                <person name="Kallen N."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="entry name" value="MDP-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17901:SF14">
        <property type="entry name" value="MAGNESIUM-DEPENDENT PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17901">
        <property type="entry name" value="MAGNESIUM-DEPENDENT PHOSPHATASE 1 MDP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12689">
        <property type="entry name" value="Acid_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01131">
        <property type="entry name" value="C1.5.2:_MDP_Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH34904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="196" mass="21801" checksum="C8EAF87A892DC419" modified="2018-01-31" version="1">MSSRLPKLVALDLDYTLWDLWIDTHVTPPLRRDGDSTNCVRDRYNHEIAFYHDVPDILHRLRAAGVIVAACSRTSAPALARQALSLLLVPAKAGDKHASSTPAIKYFDQQEIYPGSKIAHFKALHKKTGLPYSEMLFFDDERRNREVESLGVTFCLAPNGLDELTFQKGLNEWGKRHPVEVVENASGSASVASTDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JE25</accession>
    <name>A0A2H3JE25_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Microtubule binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WOLCODRAFT_24114</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAPRE family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468053">
        <property type="protein sequence ID" value="PCH40456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JE25"/>
    <dbReference type="STRING" id="742152.A0A2H3JE25"/>
    <dbReference type="OMA" id="WIKRFWD"/>
    <dbReference type="OrthoDB" id="2119228at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035371">
        <property type="term" value="C:microtubule plus-end"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051233">
        <property type="term" value="C:spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030473">
        <property type="term" value="P:nuclear migration along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035372">
        <property type="term" value="P:protein localization to microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1430:FF:000005">
        <property type="entry name" value="Eb1, isoform E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000028">
        <property type="entry name" value="RP/EB family microtubule-associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004953">
        <property type="entry name" value="EB1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036133">
        <property type="entry name" value="EB1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027328">
        <property type="entry name" value="MAPRE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10623">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEIN RP/EB FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03271">
        <property type="entry name" value="EB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140612">
        <property type="entry name" value="EB1 dimerisation domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51230">
        <property type="entry name" value="EB1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5 9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="11">
        <location>
            <begin position="2"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="EB1 C-terminal" evidence="12">
        <location>
            <begin position="156"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="113"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PCH40456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="244" mass="27694" checksum="A9B87D9E5D37B1C1" modified="2018-01-31" version="1">MGESRTELLAWLNDLLQINYTKVEQCGTGGAYCQIMDSVFGDIPMARVKMNARQEYEYLANYKVLQNVFRAHKVDKPIPVERLVKCKMQDNLEFLQWIKRFWDTNYGGHPYDPVGRRKGAPTDTPGSIAPLAPSSSRTTTASRAGGRTPITGHRSTSTQPNELVQNLQAQVKEMSVSLEGLEKERDFYFSKLRDIEIIVQQQLEALEAEGKDDPLLRDVQKILYSTEDGFEVPEQAALDEEETF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JE99</accession>
    <name>A0A2H3JE99_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_162187</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468053">
        <property type="protein sequence ID" value="PCH40221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JE99"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="173"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH40221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="304" mass="32972" checksum="2EA5AFDAC52B87D1" modified="2018-01-31" version="1">MSSPAGSSDDTLVATEESGTARSDSPLTSLDSSRCSDDERAVAGSTPQSPPLISRSRLPSPMLVCDDGPLTPKCNALFLEKSPWTKNLYLSSPRTPRIPYSPTASDVDMMEGADLELYHRLKAAKRMRVRQGVVEGQASPLESKMSRMSPMPTHIIPLKRRRVEEDTSEVGVAEGTHAAGAQQAGQSGEEPREKTREFISDYPDLRELEETGRCTITYTPSPDKGASHGDDSKSETAAVVDPTDNSDAAEDPIVQALSEVLQAYSECELHHIDLQVALVVSQVVHAIDKIMKDRIIAHHNGTIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JEG1</accession>
    <name>A0A2H3JEG1_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Autophagy-related protein 101</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WOLCODRAFT_135672</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATG101 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467831">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="742152.A0A2H3JEG1"/>
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    <dbReference type="OrthoDB" id="10259639at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:Atg1/ULK1 kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
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        <property type="term" value="C:phagophore assembly site"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="ATG101"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13292">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13292:SF0">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 101"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PCH34367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
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</entry>
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            <fullName evidence="1">Uncharacterized protein</fullName>
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        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
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            <taxon>Phaeolaceae</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
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                <person name="Kumar T.K.A."/>
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                <person name="Lindquist E."/>
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                <person name="Murat C."/>
                <person name="Nagy L.G."/>
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                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
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                <person name="Samejima M."/>
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                <person name="St John F."/>
                <person name="Stenlid J."/>
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                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
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            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="STRING" id="742152.A0A2H3JEG2"/>
    <dbReference type="OMA" id="LMRCNEF"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH37129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="520" mass="59466" checksum="E73F9E0C8BD3F97C" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JEY7</accession>
    <name>A0A2H3JEY7_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">3-phosphoshikimate 1-carboxyvinyltransferase</fullName>
        </recommendedName>
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    <gene>
        <name evidence="7" type="ORF">WOLCODRAFT_134507</name>
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    <organism evidence="7 8">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
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    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7 8">MD-104</strain>
        </source>
    </reference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:shikimate 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
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        <property type="match status" value="2"/>
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        <property type="entry name" value="DHquinase_I"/>
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    <dbReference type="InterPro" id="IPR001986">
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    </dbReference>
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        <property type="entry name" value="Enolpyruvate_Tfrase_sf"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
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        <property type="entry name" value="Shikimate/glucono_kinase"/>
    </dbReference>
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        <property type="entry name" value="Shikimate_DH-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000623">
        <property type="entry name" value="Shikimate_kinase/TSH1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21090">
        <property type="entry name" value="AROM/DEHYDROQUINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21090:SF5">
        <property type="entry name" value="PENTAFUNCTIONAL AROM POLYPEPTIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01761">
        <property type="entry name" value="DHQ_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DHquinase_I"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="2"/>
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        <property type="entry name" value="SKI"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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            <begin position="1110"/>
            <end position="1170"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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        <source>
            <dbReference type="Pfam" id="PF00275"/>
        </source>
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        <source>
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        </source>
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        <source>
            <dbReference type="Pfam" id="PF24621"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH37299.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
    <sequence length="1361" mass="145283" checksum="EF36545617EDCEE0" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JFN6</accession>
    <name>A0A2H3JFN6_WOLCO</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="2" type="ORF">WOLCODRAFT_20016</name>
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        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
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            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
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            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH35524.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JG12</accession>
    <name>A0A2H3JG12_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">WOLCODRAFT_116043</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
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                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
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                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
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                <person name="Sabat G."/>
                <person name="Salamov A."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">MD-104</strain>
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            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis.</text>
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    <comment type="subcellular location">
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            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EP450I"/>
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        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="441"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PCH38773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="515" mass="58446" checksum="F75C9192F9E78404" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JG87</accession>
    <name>A0A2H3JG87_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WOLCODRAFT_151254</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH41212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JG87"/>
    <dbReference type="STRING" id="742152.A0A2H3JG87"/>
    <dbReference type="OrthoDB" id="264917at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23327:SF42">
        <property type="entry name" value="LON PEPTIDASE N-TERMINAL DOMAIN AND RING FINGER PROTEIN C14F5.10C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23327">
        <property type="entry name" value="RING FINGER PROTEIN 127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="19"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="160"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="160"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="190"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PCH41212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="219" mass="23557" checksum="AD3F9B44647CE757" modified="2018-01-31" version="1" fragment="single">PRRAPHVDFEKELLAELTCEICFALLVQPLTTPCQHTFCAGCLHRALDHSRACPLCRAPLPDYAFFAEHPPNRVLLALVLRAFPGAYEERRAALAAEERDARLDTPVLGECAPFVSLVPSPVVCRCPVRASMCRAPTTPLLPYTIVLALHSLPSASFRPPPFPPLIPPDAPPLPRDAQPALRHDPAPRNPTSAAHAAHPSLSAAPPFAPPSAPASSSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JG89</accession>
    <name>A0A2H3JG89_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Phytase A</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Histidine acid phosphatase phyA</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Myo-inositol hexakisphosphate phosphohydrolase A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Myo-inositol-hexaphosphate 3-phosphohydrolase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">WOLCODRAFT_88733</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>1D-myo-inositol 1,2,4,5,6-pentakisphosphate + H2O = 1D-myo-inositol 1,2,5,6-tetrakisphosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:77115"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57798"/>
            <dbReference type="ChEBI" id="CHEBI:195535"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:77116"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>1D-myo-inositol 1,2,5,6-tetrakisphosphate + H2O = 1D-myo-inositol 1,2,6-trisphosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:77119"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:195535"/>
            <dbReference type="ChEBI" id="CHEBI:195537"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:77120"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>1D-myo-inositol 1,2,6-trisphosphate + H2O = 1D-myo-inositol 1,2-bisphosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:77131"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:195537"/>
            <dbReference type="ChEBI" id="CHEBI:195539"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:77132"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>1D-myo-inositol 1,2-bisphosphate + H2O = 1D-myo-inositol 2-phosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:77135"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:84142"/>
            <dbReference type="ChEBI" id="CHEBI:195539"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:77136"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>1D-myo-inositol hexakisphosphate + H2O = 1D-myo-inositol 1,2,4,5,6-pentakisphosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16989"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57798"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="EC" id="3.1.3.8"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:16990"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB468053">
        <property type="protein sequence ID" value="PCH40555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JG89"/>
    <dbReference type="STRING" id="742152.A0A2H3JG89"/>
    <dbReference type="OMA" id="REINIWL"/>
    <dbReference type="OrthoDB" id="6509975at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016158">
        <property type="term" value="F:inositol hexakisphosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016274">
        <property type="entry name" value="Histidine_acid_Pase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963:SF24">
        <property type="entry name" value="3-PHYTASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963">
        <property type="entry name" value="MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000894">
        <property type="entry name" value="Acid_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="53"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00042300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00043675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00043721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00043748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00043788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000894-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PCH40555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="436" mass="47977" checksum="FA35B8BAA76C7A16" modified="2018-01-31" version="1">MSHGWWEQPAGPRNTSSDVTTVGLDVPENIQRSWGQYSPYFPAANYVAPPRGCNITQVHLFVRHGARYPTTTNAPSYRYAVSRLASAKKFSDPRLEFLKDYEYGMPEEGLVPLGAEQSFEAGWEAFVRYGGLVGGEGRQERGIFVRASDSQRVVDSAGNWTKGFAAASRNTVVPVISAYLSEEVNSTLNSDCPAALDGTREINIWLQQFAPPIAHRLNTAAPGTKLSDEDVFSLMAMCPFESIALSGSRKRVKGKSEFCNLFSEDEWNAFEYHGDVEKYYKTGPGNALGAIQGVGYTNELLARLIEQPVRDNTTHNASLPFPLGRAIYADFSHENAMVAVFSALGLYDDVSAPDPRKIGADDRVWQANRMVPFSARMVTEILQCGGGEGRDGTYIRILVNDAVRPLARSQNPTIPPQIPITDIGFEGMVQADNMEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JGN2</accession>
    <name>A0A2H3JGN2_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WOLCODRAFT_137336</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH41336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JGN2"/>
    <dbReference type="STRING" id="742152.A0A2H3JGN2"/>
    <dbReference type="OMA" id="FAGPCAD"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF79">
        <property type="entry name" value="LACTOSE PERMEASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G01860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="218"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="306"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="340"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="373"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="400"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="440"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="469"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="54"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PCH41336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="516" mass="57379" checksum="48CE79364B4E1CFC" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JH84</accession>
    <name>A0A2H3JH84_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Chloride channel protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WOLCODRAFT_166656</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the chloride channel (TC 2.A.49) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467865">
        <property type="protein sequence ID" value="PCH36064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JH84"/>
    <dbReference type="STRING" id="742152.A0A2H3JH84"/>
    <dbReference type="OMA" id="TDWVHDT"/>
    <dbReference type="OrthoDB" id="431497at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03684">
        <property type="entry name" value="ClC_3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3080.10:FF:000013">
        <property type="entry name" value="Voltage-gated chloride channel (ClcA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3080.10">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="ClC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711:SF6">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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</entry>
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            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
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                <person name="Martinez A.T."/>
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                <person name="Benoit I."/>
                <person name="Boyd A."/>
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                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
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                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
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                <person name="Hori C."/>
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                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
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                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
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            </authorList>
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</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JII9</accession>
    <name>A0A2H3JII9_WOLCO</name>
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        <recommendedName>
            <fullName evidence="3">UBX domain-containing protein</fullName>
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        <name evidence="4" type="ORF">WOLCODRAFT_137652</name>
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        <lineage>
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    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
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                <person name="Martinez A.T."/>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
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                <person name="Benoit I."/>
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                <person name="Ferreira P."/>
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                <person name="Foster B."/>
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                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
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                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
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                <person name="Kuo A."/>
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                <person name="Morin E."/>
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                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
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        </location>
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    <sequence length="225" mass="24086" checksum="5B4F4590BE85ED9F" modified="2018-01-31" version="1">MCDAIRAQARKAAALAEQYAPGNPEAEARLQREAADEAKAISHMCDELGLEMHEINPDGHCLFSAVADQLALLNILPAAQANYTTCRLAAANYIHSHPDTFLPFLPSAGGEDAAGATSDTGLMSRAEFDQYCTTIRDTGTWGGEPEILALSSAFNVPIHVVQGGTPPVVIHQPLGSAGQSSVTDKNVAHISYHRRMYGLGEHYNSLRLKRSLAEAVKSVFHSPPP</sequence>
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    <accession>A0A2H3JL43</accession>
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        <submittedName>
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        <name evidence="7" type="ORF">WOLCODRAFT_121196</name>
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            <taxon>Agaricomycetes</taxon>
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        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
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                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
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                <person name="Larrondo L.F."/>
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                <person name="Ling A."/>
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                <person name="Sabat G."/>
                <person name="Salamov A."/>
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                <person name="Wiebenga A."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD-104</strain>
        </source>
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        <text evidence="1">Involved in the partitioning of the mitochondrial organelle and mitochondrial DNA (mtDNA) inheritance.</text>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008507"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF14881"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH42910.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="542" mass="60799" checksum="D11B6966D7A7CC88" modified="2018-01-31" version="1"> </sequence>
</entry>
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    <accession>A0A2H3JMR0</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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        <name evidence="2" type="ORF">WOLCODRAFT_100005</name>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Barry K."/>
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                <person name="Martinez A.T."/>
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                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
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                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
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                <person name="Lundell T."/>
                <person name="Martin R."/>
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                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">MD-104</strain>
        </source>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Ribosomal_biogenesis_FAF1-like"/>
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        <property type="entry name" value="PROTEIN FAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28096:SF1">
        <property type="entry name" value="PROTEIN FAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH41183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="307" mass="33682" checksum="0EC9ADF42383548E" modified="2018-01-31" version="1">MSNTDQQQLLRILEAHGQQFLESFSSSVEAGKRKDANHAIPSSSSKRRRVEEESTGSESEWSGIVSHDDSDGEAEEAEVQESSSDDEPRPGPSKQPQVVVFSDQPSTSASASKMSKAQMKAFMSSKVSKLTENVEAESSDDKSDDEEDELTNMQNDKLLHHLVHTRLLSGSLNPELDLTPAQRRKALAGRVLEAAGKAKLGEGERAVRTAERNKAAKRMREGLIAKQKQRDAEKLEEAKLLGNYHPSLKKLYESSQPTSRKRKREKGLGMGVGSFKGGVLKLSREEINSVEGKSGRGRGGKKRGGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JMU6</accession>
    <name>A0A2H3JMU6_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_90202</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468135">
        <property type="protein sequence ID" value="PCH43211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JMU6"/>
    <dbReference type="STRING" id="742152.A0A2H3JMU6"/>
    <dbReference type="OMA" id="WCNFAMV"/>
    <dbReference type="OrthoDB" id="61113at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF1">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13508">
        <property type="entry name" value="Acetyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="36"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH43211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="183" mass="20389" checksum="909F8D46899D2BCE" modified="2018-01-31" version="1">MSSPTFTVQHVAKPTDPLAIALTGGNTSLLPDLAQSMIRPIAFQIGDMYIASDENGTMIGFTMWVPPGQLLFSTEEQLKLGHMDFLSKLSDDVKAYSATATELNCYWCNFNFVKTNYQGKGVAKAMFQLALQKAHQSGFTMGLATTDARNVIIYERLGFEMKGFREMPSPWGSWPAWIFVRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JNK4</accession>
    <name>A0A2H3JNK4_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">chitinase</fullName>
            <ecNumber evidence="4">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">WOLCODRAFT_138567</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="4"/>
    <dbReference type="EMBL" id="KB468146">
        <property type="protein sequence ID" value="PCH43760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JNK4"/>
    <dbReference type="STRING" id="742152.A0A2H3JNK4"/>
    <dbReference type="OMA" id="WMGNFTA"/>
    <dbReference type="OrthoDB" id="76388at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06548">
        <property type="entry name" value="GH18_chitinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.10:FF:000005">
        <property type="entry name" value="Endochitinase B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000075">
        <property type="entry name" value="Sporulation-specific chitinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF317">
        <property type="entry name" value="CHITINASE 12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="9 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 11 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="GH18" evidence="13">
        <location>
            <begin position="165"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="61"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="505"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PCH43760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="559" mass="62508" checksum="35838AD32B3F0EF4" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JNT3</accession>
    <name>A0A2H3JNT3_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">dual-specificity kinase</fullName>
            <ecNumber evidence="2">2.7.12.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">WOLCODRAFT_64270</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
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            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.</text>
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        <property type="protein sequence ID" value="PCH38304.1"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
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    </dbReference>
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        <property type="entry name" value="Protein_kinase_ATP_BS"/>
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        <property type="entry name" value="Ser/Thr_kinase_AS"/>
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        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
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    </dbReference>
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        <property type="entry name" value="DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION-REGULATED KINASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="6 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="448"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="187"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="746"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="41"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="70"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="112"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="187"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="223"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="249"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="275"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="313"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="753"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="789"/>
            <end position="822"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="823"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="477"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PCH38304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="845" mass="92714" checksum="206CAE5B8D90583B" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JNZ3</accession>
    <name>A0A2H3JNZ3_WOLCO</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_138243</name>
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    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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        <location>
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            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="294"/>
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        <location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <begin position="346"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="382"/>
            <end position="413"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="437"/>
            <end position="496"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="503"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="525"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH43215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="585" mass="61237" checksum="357CBDD1FA6356AB" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JPW8</accession>
    <name>A0A2H3JPW8_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_154244</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468157">
        <property type="protein sequence ID" value="PCH44212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JPW8"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH44212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="70" mass="7514" checksum="079C3C29A6BD0365" modified="2018-01-31" version="1">MTFAFIISCPSGKHDAIQHARSELPANGLNPRKSGGPDILDAFSAQSGPTIEIVSGEIITNEWFDDDKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JPY0</accession>
    <name>A0A2H3JPY0_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA-splicing endonuclease subunit Sen54 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WOLCODRAFT_66993</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEN54 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468053">
        <property type="protein sequence ID" value="PCH39798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JPY0"/>
    <dbReference type="STRING" id="742152.A0A2H3JPY0"/>
    <dbReference type="OMA" id="MYMRLRH"/>
    <dbReference type="OrthoDB" id="408683at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000214">
        <property type="term" value="C:tRNA-intron endonuclease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000379">
        <property type="term" value="P:tRNA-type intron splice site recognition and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024337">
        <property type="entry name" value="tRNA_splic_suSen54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024336">
        <property type="entry name" value="tRNA_splic_suSen54_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21027">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21027:SF1">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12928">
        <property type="entry name" value="tRNA_int_end_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA-splicing endonuclease subunit Sen54 N-terminal" evidence="4">
        <location>
            <begin position="81"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="364"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="19"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="372"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="383"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PCH39798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="460" mass="51038" checksum="B83B2F8B7016666E" modified="2018-01-31" version="1">MDDSLEKPTAISQPSNQEEREEEDQSSGDEDQGPDWTKLPYGSISRPVIPKRGEKEFEPSTAGGSGLQRHVLDRARSAMLDALSAPRTISSKSISYGVWYPEIARTHVTLGKGIHFATMGHSVARASTEEDDAKKVQKRLELLPEEALYLVERGGMLCWKSADLSIAATPGLDDVEGVPMTVQQAFAEMIGKEDLTLEKYQVFAYLKRLGYSVTRAKPPTPEYPSPPALSTGRERPTSVFARIRTLLLAFWRLLHLIPRKLDWWRPLRRCGWLNHMDNRSIFSSLRFLPSGHDVPLHVKGIPGSLLSPYEIFFNLYKPSTPFKKTAPPPPDFSVVVVNARTTPMPSLTELTNLFGTLPELSPPIPRKRQSFAQQKAAAANTPPQAPPPPVPPPPVASEPLLQRLLPWFFPPPPTGHPARNPNPFLSLKTGKKMIVIAAVDAGTISFFRFGQGVFTEWSMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JQG3</accession>
    <name>A0A2H3JQG3_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">DNA polymerase</fullName>
            <ecNumber evidence="20">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">WOLCODRAFT_133199</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25 26">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 20">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 20">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 20">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="20"/>
    <dbReference type="EMBL" id="KB468157">
        <property type="protein sequence ID" value="PCH44386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JQG3"/>
    <dbReference type="STRING" id="742152.A0A2H3JQG3"/>
    <dbReference type="OMA" id="CNNCRPR"/>
    <dbReference type="OrthoDB" id="2414538at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043625">
        <property type="term" value="C:delta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008296">
        <property type="term" value="F:3'-5'-DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006287">
        <property type="term" value="P:base-excision repair, gap-filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045004">
        <property type="term" value="P:DNA replication proofreading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006297">
        <property type="term" value="P:nucleotide-excision repair, DNA gap filling"/>
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</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
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                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
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                <person name="Kumar T.K.A."/>
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                <person name="Lindquist E."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
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    </evidence>
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</entry>
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                <person name="Benoit I."/>
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                <person name="Gaskell J."/>
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                <person name="Heitman J."/>
                <person name="Hesse C."/>
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                <person name="Igarashi K."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
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    </dbReference>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468168">
        <property type="protein sequence ID" value="PCH45111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JT10"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH45111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="309" mass="34757" checksum="EA3FD15CE79AE23D" modified="2018-01-31" version="1">MQHKCQYCRCGPLSLCRRAYIRRAQSEECLHAPHTLGLSLTATDFSTAARFTMNPEELNGVMYPNGTQVRWWPLEAFPRNPQLINHPDERLKGRVPHDTIMRYRRGSPPPPHDWEEVMSSSSEGEWTDLVSSGAESDDVPTQNLSCSPRTAEQLDLELPPTLRRPPKTSPGPSTEHFERLSPRERLYAARSETPSSAILSEITQGLLRRDQPLNISQSSFSLHTEPIHGEGSSRARHLDIPARGNVAHALERDLVAPMRPRKYGRRFVKPPPIAKVASMDSSEEERIVEECSPHETFIGLDGNGYVKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JUA2</accession>
    <name>A0A2H3JUA2_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transport protein particle complex subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_137376</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH41408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JUA2"/>
    <dbReference type="STRING" id="742152.A0A2H3JUA2"/>
    <dbReference type="OMA" id="HEAKNDE"/>
    <dbReference type="OrthoDB" id="10252102at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14825">
        <property type="entry name" value="TRAPPC2_sedlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006722">
        <property type="entry name" value="Sedlin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12403">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04628">
        <property type="entry name" value="Sedlin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH41408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="181" mass="19845" checksum="8789C37AD8E8239E" modified="2018-01-31" version="1">MSHHLFLLSPSDTPLYNLTHFSSKPSQAAATSPLASNLPSWSTSAFAGTLTALSGATAATQSHHAQGGTVRIGGGQDRHVIQMIANASLDVIEEVVRKESVMYLKSVDKFNEWTVSAFVTPGNMKFVLLHEARNDDGIKAFFTEVWELYVKTMLNPFHTAHTPIRSPVFDARVRASAKKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JUG2</accession>
    <name>A0A2H3JUG2_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">AAA ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">WOLCODRAFT_137958</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family. BCS1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB468124">
        <property type="protein sequence ID" value="PCH42539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JUG2"/>
    <dbReference type="STRING" id="742152.A0A2H3JUG2"/>
    <dbReference type="OMA" id="WMTLYQR"/>
    <dbReference type="OrthoDB" id="10251412at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19510">
        <property type="entry name" value="RecA-like_BCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000768">
        <property type="entry name" value="Probable mitochondrial chaperone bcs1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057495">
        <property type="entry name" value="AAA_lid_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014851">
        <property type="entry name" value="BCS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050747">
        <property type="entry name" value="Mitochondrial_chaperone_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23070">
        <property type="entry name" value="BCS1 AAA-TYPE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25426">
        <property type="entry name" value="AAA_lid_BCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08740">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01024">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="BCS1 N-terminal" evidence="14">
        <location>
            <begin position="52"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="269"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PCH42539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="482" mass="53130" checksum="4A7B6CCA30D44C6E" modified="2018-01-31" version="1">MQLQNVPAATELPGATGAVAAVQTSAAGQGGGSILSVLIGDNPYFQAGFGLMGVGVGLSALRQAVLLSSVALRRRMLVSLEINNKDPAYDWFLTWMAHRSGEIAGAPRTRSLLSPESWTRSHQISVQTMHEQRKNGSSSVLFKLVAGPGTHYIRYHQAWIQVKRERETRSQQLMSGIPWETVTLTTLSRDRDHFRKLLAEARDMALRAQQGKLVLYTAMGTEWRPFGQPRRKRPLHSVVLADGVAQRIERDVKAFMERRQWYEDRGIPYRRGYLLHGPPGSGKSSFIQALAGALSYDICLLNLSERGLADDKLIHLLSNTPERSFVLIEDVDAAFNKRVQTTADGWQSSVTFSGFLNALDGVASGEERIIFMTTNHPERLDPALIRPGRVDLAVLLDDATPEQARRLFVRFYRGGDDTSAEISEVDSKALEKLGVLVEETVEQGVRAGRRVSMAALQGLFIRSSAEEAAEGVKGLLAPQQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JVJ4</accession>
    <name>A0A2H3JVJ4_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-CoA N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_142952</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468053">
        <property type="protein sequence ID" value="PCH40177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JVJ4"/>
    <dbReference type="STRING" id="742152.A0A2H3JVJ4"/>
    <dbReference type="OMA" id="GANSHEW"/>
    <dbReference type="OrthoDB" id="9975416at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00299">
        <property type="entry name" value="GST_C_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054416">
        <property type="entry name" value="GST_UstS-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22041">
        <property type="entry name" value="GST_C_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="204"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH40177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="370" mass="41649" checksum="1767CC960CC6CE95" modified="2018-01-31" version="1">MPRLILAEADALHAAFEEAFTQSVMMKMIPLMAVPTYKVLHPPSAAYFARAKELETGLQIQEFSPDGAIREMQWKELQEAFAKMSQWMSMDGTERQFFMGDKTCYADITVASWMVWMKRCLGANSHEWAQVETWDGGRWGRFMEYFEQYAMAAQQTTDIAETKSMLHLGSRGLHTAASEVRIAMIIDTSPETSGDHTEPSSEVPVIRYATPADIEELAPLFLASVDTSLPGITFSARPGYELAKICTHLETRLFPTPTIRTFCLELPSSPRIIGYASVKPKSTVKGLGDTPELDMLFVKVGMAGRGYGGLLMERVQRECRETGLGVHVFKRNERALRFYHKWGFAIVVEEEMNIGEGNVEQVYGMRWAPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JVS4</accession>
    <name>A0A2H3JVS4_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WOLCODRAFT_143797</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the Mrp/NBP35 ATP-binding proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468124">
        <property type="protein sequence ID" value="PCH41938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JVS4"/>
    <dbReference type="STRING" id="742152.A0A2H3JVS4"/>
    <dbReference type="OMA" id="ANFACSM"/>
    <dbReference type="OrthoDB" id="1741334at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02037">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001119">
        <property type="entry name" value="Iron-sulfur cluster carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044304">
        <property type="entry name" value="NUBPL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42961">
        <property type="entry name" value="IRON-SULFUR PROTEIN NUBPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42961:SF2">
        <property type="entry name" value="IRON-SULFUR PROTEIN NUBPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="8"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="23"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PCH41938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="323" mass="33846" checksum="8A48D38FC1278832" modified="2018-01-31" version="1">MSTIRRAFATSPAVRHDNPLGLPARRPAPQIPRRGGPIQKRPLPYVRKVLAVASGKGGVGKSTVAVNLALSLAMQAHAATGAPARVGILDLDIFGPSVPKLMGLDAAPEPRLTQSGAIVPLTNHGLPCMSMGLLLPREANADTAVVWRGLMVQKAVQQLLFDIDWREPPQEGGAELDVLVLDLPPGTGDVPLTLGQLVNVDGAVIVSTPQDVALSDVRKGVTMFQKISVPITGLLLNQSHFLCPSCATPHHLFGSPERFHATAASMGVPVLGALPLVPAVSEASDGGAPFVLAGTSTNTEKAGVEWRETMAAVAKSVWRFLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JXQ3</accession>
    <name>A0A2H3JXQ3_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WOLCODRAFT_54666</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
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                <person name="Barry K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">MD-104</strain>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="88" mass="9645" checksum="D8C8828CA812CD02" modified="2018-01-31" version="1">MSTKGPSGGDPSIQAALPNFSSALSSSSRAREAYIAFRAHERRVVSLRSAIPVTRVFLRNVSAICAPYPLHIAFDFANCNLREWHGKN</sequence>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
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                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
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                <person name="Martinez A.T."/>
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                <person name="Kallen N."/>
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                <person name="Larrondo L.F."/>
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                <person name="Lundell T."/>
                <person name="Martin R."/>
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                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
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                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
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                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468157">
        <property type="protein sequence ID" value="PCH44029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JYP1"/>
    <dbReference type="OrthoDB" id="2789810at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH44029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="463" mass="52564" checksum="78AA28AFC9E4296F" modified="2018-01-31" version="1">MTDKMEGQPAASCIIEGSAFDVEARLLREIEWRPPREWWEILPSRRDALLPQFNSKTAASRIPTEIWDKILGYLRDEPETLGIAEEVCRGWYPTSHRLKSRRILNSYYSKEGVRLYARYIKTIPRPRRSEIQVNLVGSAAEEGKQRSRTGNKRRSLAHVGTFAAMFAGGQLPRLSRLTIKDGEWTPGAMPQSVFLHLSSFHSITRLTLADITLPSITVLLRLVCAFDRLEKLGTSYLRLLDRRVPPAGRRWAPSPTLKKLAFCDLNWPDKLYPYFKLETSSGSEIVLFLLNALSCSDLNQLLHHVGKALRVVSIDPLKSLLGVNPHSIQPLRVPDVDLSRNVGLRELNIGIHGDIPAALLERAVTYDVIQRMIISTYPTVLEQIIIEVSLNPSASIMSHVLLALRRAVCPPDNPLTPEKYTSMKLVVLRFRKADETSKRQMEADWDRLAPIWFPSFYSRGIIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JYQ0</accession>
    <name>A0A2H3JYQ0_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6535 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_48684</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468135">
        <property type="protein sequence ID" value="PCH43008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JYQ0"/>
    <dbReference type="OMA" id="SARWINS"/>
    <dbReference type="OrthoDB" id="2753780at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045338">
        <property type="entry name" value="DUF6535"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20153">
        <property type="entry name" value="DUF6535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6535" evidence="2">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH43008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="128" mass="13677" checksum="18D56E1C36714D83" modified="2018-01-31" version="1" fragment="single">WQSCSDLVWSHEQDIVRRWKDELDALLTFSGLFSAVVTAFGAVYITQLQPSSPDPTPVYLAHISAQLGSFIAHAGGLNSTVPPLPSGDLPATRPSNPPGVVVVVNILWSSALVLSLIAATVDISVKQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JYY0</accession>
    <name>A0A2H3JYY0_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">sphingolipid C(9)-methyltransferase</fullName>
            <ecNumber evidence="14">2.1.1.317</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">WOLCODRAFT_25044</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">MD-104</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CFA/CMAS family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.317" evidence="14"/>
    <dbReference type="EMBL" id="KB468124">
        <property type="protein sequence ID" value="PCH41944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JYY0"/>
    <dbReference type="STRING" id="742152.A0A2H3JYY0"/>
    <dbReference type="OMA" id="GFKTWLF"/>
    <dbReference type="OrthoDB" id="412182at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052290">
        <property type="entry name" value="Sphingo_C9-MT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45197:SF1">
        <property type="entry name" value="SPHINGOLIPID C9-METHYLTRANSFERASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45197">
        <property type="entry name" value="SYNTHASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G04190)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02353">
        <property type="entry name" value="CMAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 16" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="10" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="7 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00039020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PCH41944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="483" mass="55215" checksum="A37CA6C4AF7BBCEE" modified="2018-01-31" version="1" fragment="single">MSQPSVKVTNTPAIKNAPSVGLAEGNGSFNNIHLAGLIIVVPWFVKRTLPVVCYGGFKTYLFMVLLLGVPITIAYWTAMSMYGPRKNSKVQLPGKNIEEYITIHDPELKAKFHGTEKIPMQVFHDAYFDKKIDFNGDVLDIMEQRHDWAKFIFTLELFKYVFTVLIPDVIMHKRSQDEEQVRGHYDRGDDFYEWFLGPRMVYTSGVVRDLTIEESLEKLQDNKLTLVCEKLDLQPTDRLLDIGCGWGTLCAFAAKNYGCEVTGVTLGRNQTKFGNERIQANGGDPSRARVLCLDYRDIPGERGAYTKMVSLEMAEHVGIRRYGTFLRQMYDLLEDDGIFVLQVAGIRPAWQYEDLIWGLFMNKYIFPGADASCSLGWVVNQVEAAGFEVKNIDVLGVHYSATIFRWYKNWVSNKERVIEKYGERWYRIWVFFLAYSTIISRNGGASVFQLTLHKNLNAYPRILGVPSHSSIHVHPAREIQPVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JZ29</accession>
    <name>A0A2H3JZ29_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WOLCODRAFT_121550</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9 10">MD-104</strain>
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        <text evidence="1">Belongs to the WD repeat CDC20/Fizzy family.</text>
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        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:1905786">
        <property type="term" value="P:positive regulation of anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033010">
        <property type="entry name" value="Cdc20/Fizzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056150">
        <property type="entry name" value="WD40_CDC20-Fz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918">
        <property type="entry name" value="CELL DIVISION CYCLE 20 CDC20 FIZZY -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918:SF8">
        <property type="entry name" value="FI02843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24807">
        <property type="entry name" value="WD40_CDC20-Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CDC20/Fizzy WD40" evidence="8">
        <location>
            <begin position="110"/>
            <end position="441"/>
        </location>
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        <location>
            <begin position="241"/>
            <end position="282"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF24807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PCH43138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="463" mass="50374" checksum="F78BFD8992206DD5" modified="2018-01-31" version="1">MASTVDLDFASEIDFNGPGHTSSADRFISAPRESAIPLNVTPRTNRIARNFGLADERMLKFSDNARRSASGNDLTLQRTHVQPLFAAASKASSLSASAHLGARKQFLLALDGPGIPSDPFAFPLSWSKRNAIAVACGRDVYYQDLNTRDITHLSTLAKRSYGRLTSIEWSRDSPGLLAVGTSLGSVQLLDADSKKLMREWRCTDWGVVGGMNWNEDLLAVGVSDGTVELFDARESKVVGKLSMHKNKVHGVQWSLDGNYLATSDHDGIVQIWDARTSRILSNTDRKSGKMRHGTAPVKALAWCPWKSDLLATGSTYPDGKIRVWSVNSSLASPPVHTISVNTSITSVVWSPHCKEILSTHGTSWQQLAPTAEPPPGVTVLPTGAIPVKTTFTNSVTVHAYPSLKRVVSIPAHSAAVGHSCLSPDGTMVFTVCPAEEAMKMWKVWGMPQNRVRRESAFDKCTIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K077</accession>
    <name>A0A2H3K077_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_17354</name>
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    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468113">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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        </location>
    </feature>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH41827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="199" mass="20723" checksum="7248982959F6C86A" modified="2018-01-31" version="1">MGASKPKPCWTKKTVSTAAAEQNVAVASGSSVGSTSIQQPILPILPTEDAPPALPTEDTLPTSSAQDVPPAQVAPPTEDTLSTPPTENALPTPAQATPAQPTPIMDPAEVSPLTTLPRSCNGSPSPLTGDKRKGHPVKASPSNPDKHCCRDKTEAQLPDVIEDEEEPQSKGKGKGKGKGLKALLPLPTEKRNTRLFGHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K0T4</accession>
    <name>A0A2H3K0T4_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Magnesium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">WOLCODRAFT_139241</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion inner membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468168">
        <property type="protein sequence ID" value="PCH44789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K0T4"/>
    <dbReference type="STRING" id="742152.A0A2H3K0T4"/>
    <dbReference type="OMA" id="TRNNCII"/>
    <dbReference type="OrthoDB" id="10251508at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:mitochondrial inner membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Mrs2_Mfm1p-like"/>
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    </dbReference>
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        <property type="entry name" value="Inner membrane magnesium transporter mrs2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR13890:SF0">
        <property type="entry name" value="MAGNESIUM TRANSPORTER MRS2 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13890">
        <property type="entry name" value="RNA SPLICING PROTEIN MRS2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22099">
        <property type="entry name" value="MRS2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="381"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="411"/>
            <end position="432"/>
        </location>
    </feature>
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        <location>
            <begin position="285"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU366042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PCH44789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="471" mass="52712" checksum="DD0616BBFC6BB606" modified="2018-01-31" version="1">MHTVLKRASASYVRALKHPSAQRDGLRLTGSYCASSRKPNSCRVWIGWNSGILSEPSVRHVPTTYHGSSLSPPRPCFGARHFSWIPWKLNLRAPEPYNEPSDGQEEAAKVAMLEKAMKGRQPADLMLRCTILDADGNVKTISGQFRKADLCAEHRLNPRDLRKIDSRIPNLVPTVLVRKEAILVNILHIRALVKADAVVLFDTYGSADSRLHSVFLYHLEHNLKGKANGLPYEFRALESVLLSVLSALEAEMVFIRNLVGGLLAELEDDIDHDRFKRLLHYSRRLASFQNRAKLVQEALEEVLEQDEDLAAMYLTDKMNGNPRKLSDHEDLEVLLESFHKQVEEIVNEAENIQSNVQSTQEIVELVLDSNRNALLALDLKISIMTMGVGIGTLVAGLFGMNLKSHIEDNPYAFALMSVCSIVMASAFSWVGLRRLARVRKVRLATNGRKNSPTLKDSLPLNLRGRGDGWSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K284</accession>
    <name>A0A2H3K284_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SRPBCC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_132673</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468135">
        <property type="protein sequence ID" value="PCH43154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OMA" id="GNFRIAW"/>
    <dbReference type="OrthoDB" id="509124at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07822">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH43154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="163" mass="18681" checksum="A0BE88C7FC11F8E2" modified="2018-01-31" version="1">MTNLPPSPYQGVLNLNASAIIDAPIEKVWDLLTNFQSYSEWWTKKPLPDQTPHEGAYLLMEVHIPPTEDRKHKPTSRPLEKITAVDHGSYRIAWVNLLPQWLLHAERWQALSVVEDGKTLYETREVMSGPAAWIVRWFLGADLQKGFEAVAEGLKKRAEQLQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K2V5</accession>
    <name>A0A2H3K2V5_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_75141</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468146">
        <property type="protein sequence ID" value="PCH43384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K2V5"/>
    <dbReference type="OMA" id="CPAYAYS"/>
    <dbReference type="OrthoDB" id="337581at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097196">
        <property type="term" value="C:Shu complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28498">
        <property type="entry name" value="ZINC FINGER SWIM DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28498:SF1">
        <property type="entry name" value="ZINC FINGER SWIM DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04434">
        <property type="entry name" value="SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="2">
        <location>
            <begin position="46"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH43384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="115" mass="13025" checksum="D6FE92E95B3DEBA0" modified="2018-01-31" version="1" fragment="single">LESLRFFFPDTLLLAALDLIDRESVIKYKTPWGRAQYEVLGSTNSYAVFPEMLLTNMQPMAYCTCPAFAYSVLLSGSQLMCKHLLATILAERLSRCSERHVDPNEFANIVVRQCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K3C6</accession>
    <name>A0A2H3K3C6_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA ligase phosphodiesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_165295</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468168">
        <property type="protein sequence ID" value="PCH44648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K3C6"/>
    <dbReference type="OrthoDB" id="3265241at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003972">
        <property type="term" value="F:RNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015965">
        <property type="entry name" value="tRNA_lig_PDEase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08302">
        <property type="entry name" value="tRNA_lig_CPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA ligase phosphodiesterase" evidence="2">
        <location>
            <begin position="94"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH44648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="320" mass="36878" checksum="285084C576670692" modified="2018-01-31" version="1">MEASVLSRAYRALSPSPARQITYCADPLRLILAFKLAQEVDEVTKEKESEVENQNSQNKPLVQEPPQPQMPKIEEQNGTTEIKSGTVNIEQEGILEQKKTKKPMAPNYEIGVRCYSIIPDVDLRKVVEQALPTEIQAMWKERCQSGHLASTTHIQLAHYRMRLHHRGAEVWRWCWSFLTKRDPVWFHFRLTHLVWDDRIVLAVVDGLEFDASEARNAGVKAEDGNVFVDGLPDWICSSLHIILVKNNEKVSPGEARALVRQWKEAPQSVNSIPLDDVQGKGYMRKFFGRILKLNYLRNLMAQRREEKQEKELSKQEVANR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K3Z4</accession>
    <name>A0A2H3K3Z4_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WOLCODRAFT_90172</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468135">
        <property type="protein sequence ID" value="PCH43147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K3Z4"/>
    <dbReference type="STRING" id="742152.A0A2H3K3Z4"/>
    <dbReference type="OMA" id="EDSIGPW"/>
    <dbReference type="OrthoDB" id="5283654at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF9">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="8"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PCH43147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="325" mass="35302" checksum="31763313EFB52637" modified="2018-01-31" version="1">MSTTASQYTVAIIGATGNLGKDITNVFLTSYKASFAKIVVVARDPSSPAAKQFAEQGAEVRPVNPADAVGSLTRAFASVDVVVNTVSGSSSEYSDAIFQAALNVGAKVYFPSEFGSDHRLNDFPGWDDLGWNSKREHVRKARELAKGKVKIIALYTGLFQEGTFGVSLLGFDHTSLTYTFVGSADAKTAVTAKADIGRSLAELSLLALSPESAARVPDDVRIAGQNVSYRQTKEIVERVRVELRVEPRGEITLKSLDLTEERAKLREAQLKSPAPGPLGHIKILIGEGKMDFSENHNELVNPGQKNWKWKSVEEYIREVRGAPFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K5R0</accession>
    <name>A0A2H3K5R0_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CREG-like beta-barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_75371</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468146">
        <property type="protein sequence ID" value="PCH43767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K5R0"/>
    <dbReference type="STRING" id="742152.A0A2H3K5R0"/>
    <dbReference type="OMA" id="ITLSMRW"/>
    <dbReference type="OrthoDB" id="2138282at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055343">
        <property type="entry name" value="CREG_beta-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37273:SF1">
        <property type="entry name" value="ADL397C-AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37273">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13883">
        <property type="entry name" value="CREG_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CREG-like beta-barrel" evidence="1">
        <location>
            <begin position="3"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH43767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="188" mass="21004" checksum="3E3E3E4860CF48FB" modified="2018-01-31" version="1" fragment="single">ALLARNLVDLSPSGLGMMATVYPEDHVTLAGDPFSLQEYYASCHENGSLTLLFMPISRHSQNVLGSPSRAASISVADEHPDASRARVALIGNVTIFEDIRSAPNVDTIQQCYLRRHPDARRWLPGPREPHIAYWARFDPHTVYYVGGFGSEHYIGYIPLDMYQAVRTSADHDVSEDVLHDQEQQTVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K6N2</accession>
    <name>A0A2H3K6N2_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dystroglycan-type cadherin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WOLCODRAFT_164915</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
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            <begin position="168"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="205"/>
            <end position="443"/>
        </location>
    </feature>
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        <location>
            <begin position="15"/>
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        </location>
    </feature>
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        <location>
            <begin position="168"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="228"/>
            <end position="241"/>
        </location>
    </feature>
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        <location>
            <begin position="305"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="414"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="427"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PCH44437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="460" mass="50063" checksum="AD0B26904542E5D4" modified="2018-01-31" version="1">MDQDSFRKLLQTPKAGSSSASTSRGSLLTATASKSKQKTTDASQPAFKPRTVKKKAQGTQQYRDRATERRLGLDNDYAQVEALAADFERRNADNADRKAVEEQRRYLGGDSDHTVLVKGLDHALLEQNRARVAASTTAEDDATLEQAFLEASSSIPRKRTREEIIQELKSKRAKGGDGVEGEAEEKKSAVNADLALEEAKKAGKFRPIGFKPIGSEQGEKTKKKKLKQKVDGKGFNTEKKKPNSGTEAGGKPTDISPVPAPLDEAGPSSLTPPTKPEPQPKPDPEPIDDNFDIFADAGEYTGVDLGDDDNSDGDVDMDASPRKEEPEEQALPVKGRWFAIEEEDAPKATSPQPLPAAAAEPRNEKSHSPVAPSAVHSDQEDEEEERPMRLQPLASSALPSIRELLELDSAAGKAGKRRSRKEKKKDKRGDGDGKVDKDKIDRDYKQLKAYTDKKAAAEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3ISR5</accession>
    <name>A0A2H3ISR5_WOLCO</name>
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            <fullName evidence="1">Uncharacterized protein</fullName>
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    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_129563</name>
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    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467831">
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH33026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="455" mass="51704" checksum="AE763CEEDCB7FA36" modified="2018-01-31" version="1">MDNDPQTSAIAQLHDRHAHPFQPLLESTSCRDLRSEASRSIAKVSLTDADFAEGAGTSWYDDYGLRNDTLYVTSWLSAGWTNDVMTIGNLIYLALITSRVPVLPPFTSHIGGSSVPIAFSEIFDIQRLSIALNLPILEWHQIKDIELAESLKEQDELGCWNIWEVDNIHSGGPRGSYSALILDLVCAQDISYTRAPRWVKLIPGFEHDSHSTFWSLARLAFPGTRNDVLADPVAHPTRPSEQHGAVIPPDEQMLCYDYLYYVCGNQPFEYEYDYSPAWRFVVQHFRWTSQLENLALGYVRRTLRIPDGQAIPPYITIHARRGDFTEWCGDIPVEDCFAPLSAFARRVAEVQQDLRERHGIEVSHVIMTGDEKDESWWDAVHELGWSRIDHNAERTVQLHGKWYPVILDAVIQSLGMGFVGTDRSTFSILARRRVVDWNDGAIRTVKWGRPDSDAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IT35</accession>
    <name>A0A2H3IT35_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WOLCODRAFT_21787</name>
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    <organism evidence="6 7">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
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        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
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            <taxon>Agaricomycotina</taxon>
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        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH33152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OMA" id="AYWFMGA"/>
    <dbReference type="OrthoDB" id="196103at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010291">
        <property type="entry name" value="Ion_channel_UNC-93"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051617">
        <property type="entry name" value="UNC-93-like_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294">
        <property type="entry name" value="ET TRANSLATION PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294:SF59">
        <property type="entry name" value="UNC93-LIKE PROTEIN C922.05C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05978">
        <property type="entry name" value="UNC-93"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
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            <begin position="132"/>
            <end position="157"/>
        </location>
    </feature>
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        </location>
    </feature>
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            <end position="221"/>
        </location>
    </feature>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
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            <begin position="298"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="377"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="433"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PCH33152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="492" mass="53847" checksum="39883B361043A1CB" modified="2018-01-31" version="1">MSLSDYSVEKDNASGSVVPDLEGPAAPAVFERPTGIKGLYYNPVVQVFMLGFVCFMGPGLFNALNGLGGGGQLSTTTSANANVALYATFAFTAFFAGSINNVLGPRLTLLLGSSGYALYIGSYLAINIHPNAGGFVIAAGAVLGICAGLLWTAQGSLMLAYPTESQKGIFIGIFWSVFNLGGVVGAAVALGRNFHSTANSVSNGTYIGFLILTLIGVTIPMTMANPNKMIRTDGTKVTTLRHPSWKTELYGLWVTLRTDPYILLLFPMFFASNWFYTWQFNDYNAAIFNIRARALNNLVYWTSQIVGSVAIGFLLDQKALSRRFRAYAGWIVLFFMVFVVHIWAYFYQKHYTRETVAVLTNDQDKIDIYDKEYVGRVWLYIFCGMLDAMWQTTAYWIMGAMSNDPAKLANLTGFYKSLQSAGAAGIWRGDAVSLPYINIFVSTWALLVGGLLFALPMIHMRVKDHTEAADEIGDILAHMETPAAVPAPKPEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IWA1</accession>
    <name>A0A2H3IWA1_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_135447</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
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        <source>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
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                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
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                <person name="Young D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
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                <person name="Benoit I."/>
                <person name="Boyd A."/>
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                <person name="Gaskell J."/>
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                <person name="Gorecki P."/>
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                <person name="Hesse C."/>
                <person name="Hori C."/>
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                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
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                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
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                <person name="Sabat G."/>
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                <person name="Samejima M."/>
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                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <dbReference type="PANTHER" id="PTHR13018:SF143">
        <property type="entry name" value="CSC1_OSCA1-LIKE 7TM REGION DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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        <property type="entry name" value="PHM7_cyt"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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            <end position="59"/>
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    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="8">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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    <feature type="transmembrane region" description="Helical" evidence="8">
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    <feature type="transmembrane region" description="Helical" evidence="8">
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    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="757"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="792"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="11">
        <location>
            <begin position="38"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="12">
        <location>
            <begin position="212"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="9">
        <location>
            <begin position="502"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="domain" description="10TM putative phosphate transporter extracellular tail" evidence="10">
        <location>
            <begin position="947"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="288"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="382"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="833"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="950"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1001"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="393"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="836"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="857"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="868"/>
            <end position="885"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PCH35282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="1030" mass="114308" checksum="48906381CA62E4FA" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J0M6</accession>
    <name>A0A2H3J0M6_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent DNA helicase CHL1</fullName>
            <ecNumber evidence="17">5.6.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">ATP-dependent DNA helicase chl1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Chromosome loss protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18 19">DNA 5'-3' helicase CHL1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">WOLCODRAFT_166453</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="20">ATP-dependent DNA helicase important for chromosome transmission and normal cell cycle progression in G(2)/M. May have a role in changing DNA topology to allow the loading of proteins involved in maintaining sister chromatid cohesion in the vicinity of the centromeres. Has a specific role in chromosome segregation during meiosis II.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DEAD box helicase family. DEAH subfamily. DDX11/CHL1 sub-subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="17"/>
    <dbReference type="EMBL" id="KB467854">
        <property type="protein sequence ID" value="PCH35736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J0M6"/>
    <dbReference type="STRING" id="742152.A0A2H3J0M6"/>
    <dbReference type="OMA" id="QTHQFRD"/>
    <dbReference type="OrthoDB" id="267079at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034085">
        <property type="term" value="P:establishment of sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18788">
        <property type="entry name" value="SF2_C_XPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006554">
        <property type="entry name" value="Helicase-like_DEXD_c2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010614">
        <property type="entry name" value="RAD3-like_helicase_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013020">
        <property type="entry name" value="Rad3/Chl1-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00604">
        <property type="entry name" value="rad3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472:SF41">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE DDX11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06733">
        <property type="entry name" value="DEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00488">
        <property type="entry name" value="DEXDc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="9 24" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="23">
        <location>
            <begin position="8"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="125"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="448"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="448"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00029709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00044998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00045008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00045702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="PCH35736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="898" mass="99868" checksum="FF3C01013ADEC75F" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J1B0</accession>
    <name>A0A2H3J1B0_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_156167</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467854">
        <property type="protein sequence ID" value="PCH35475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J1B0"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH35475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="313" mass="36205" checksum="AAC88D3BD7D079D6" modified="2018-01-31" version="1">MAKHDKASSVPPLTEAQKAVVMTKLRDYQQAATYSVERMEISNILTQELKSKFEDLAEVEDSVLAAKVREWLRNHSQAIGSQSSNEEVQIGKKLAMWRLWAKEHSDGVKVRQAKLMAESNEENKDQVVFWGRAGTELWSELTKEQQEEYEGQVKSHEGTMAAVQPNKVNRKMHSWCKAFADQMATELGVQTLVLTAYPKDNQAYVELHDFNDALDLAPSFKNRAEWENDLWEQWKAYSHEVILDKKTSQGSDEEDDSGDSDDDRKFSLPVDDEGLPILPPYNPRKQLRPARMRQIIRLFLNRHYHEWVLLIKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J2Y3</accession>
    <name>A0A2H3J2Y3_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_159482</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467878">
        <property type="protein sequence ID" value="PCH36526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J2Y3"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="178"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="235"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH36526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="319" mass="34267" checksum="C62917B410F71672" modified="2018-01-31" version="1">MLAQRGSRPDDKSQRSVQLRAPIQAQLKSPTWGNEEDDGPRTHPPAVSRYETRPSLTRVGEAPPALPTAPLDWTTPSCTLPRAPTRKGGPTRGGSPLHQRPSSGQRRKHLGSQHNGAHRPPWTRRASRQAGYSPSARGGTIRLNNWDLRRCPGPSTKHPRPSVDPRGNPARAFIERGAASAQATTAAQALGTEKTRAAPQGPLDNRVQTRTPPDSSGSDKRQHTSGRPYGKGNRPSHTTQPQATATSPPAYLTQGWAKAHSRQGDPPRTKSNGSAACLNNRATPSADRAQTGRAAGTPPDRVLNDRQRPSTSNRAIATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J3Z7</accession>
    <name>A0A2H3J3Z7_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alcohol dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WOLCODRAFT_140680</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD-104</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.1" evidence="3"/>
    <dbReference type="EMBL" id="KB467898">
        <property type="protein sequence ID" value="PCH36972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J3Z7"/>
    <dbReference type="STRING" id="742152.A0A2H3J3Z7"/>
    <dbReference type="OMA" id="VITVHYQ"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08297">
        <property type="entry name" value="CAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000039">
        <property type="entry name" value="Alcohol dehydrogenase AdhP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF3">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="8">
        <location>
            <begin position="25"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PCH36972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="354" mass="37972" checksum="41AF65B7A9F62201" modified="2018-01-31" version="1">MPSVTIPSRIRAAVTREFSTKTYVTDSYPLKSPADLEPGECIVKLEYAGVCHTDLHFMAGEWAIKPRLPSVGGHEGVGRVIALDSMYSGNVRIGDRVGIKYCVRSCLNCDHCRRGFEQNCPNRIISGYHVDGTFAEYMVAFTDHLIPIPDGLDSAAAAPILCAGLTVYNSLSQLNTHVGGWIVIPGAGGGLGHLAIQYAIARGLRVLAIDSGPKRELCLSLGAEAFIDFTECTDIVSAVQAAVSDPMGAHAALIIAPSNEAYIHAGWYVRPQGTILCIGSPQEVTGLPMARIIDAGLNIIATQTGGRQVAHEALQLAARGKVQCHYTEYPLEKINDVFEAMIKGRLVGRAVIKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J4B7</accession>
    <name>A0A2H3J4B7_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">glycine--tRNA ligase</fullName>
            <ecNumber evidence="4">6.1.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Diadenosine tetraphosphate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">WOLCODRAFT_28891</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2 ATP + H(+) = P(1),P(4)-bis(5'-adenosyl) tetraphosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:34935"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58141"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.14" evidence="4"/>
    <dbReference type="EMBL" id="KB467909">
        <property type="protein sequence ID" value="PCH37036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J4B7"/>
    <dbReference type="STRING" id="742152.A0A2H3J4B7"/>
    <dbReference type="OMA" id="HFVNFQR"/>
    <dbReference type="OrthoDB" id="10267474at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004820">
        <property type="term" value="F:glycine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070150">
        <property type="term" value="P:mitochondrial glycyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00774">
        <property type="entry name" value="GlyRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.720.200:FF:000001">
        <property type="entry name" value="Glycine--tRNA ligase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000004">
        <property type="entry name" value="Glycine--tRNA ligase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000158">
        <property type="entry name" value="Glycyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000010">
        <property type="entry name" value="Glycyl-tRNA synthetase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027031">
        <property type="entry name" value="Gly-tRNA_synthase/POLG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033731">
        <property type="entry name" value="GlyRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002315">
        <property type="entry name" value="tRNA-synt_gly"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00389">
        <property type="entry name" value="glyS_dimeric"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003211">
        <property type="entry name" value="PRK04173.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745:SF0">
        <property type="entry name" value="GLYCINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745">
        <property type="entry name" value="GLYCYL-TRNA SYNTHETASE/DNA POLYMERASE SUBUNIT GAMMA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01043">
        <property type="entry name" value="TRNASYNTHGLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 16" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="15">
        <location>
            <begin position="178"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="124"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00051967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PCH37036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="657" mass="73305" checksum="3DD50FB3BA5B3531" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J4D0</accession>
    <name>A0A2H3J4D0_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_83447</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467909">
        <property type="protein sequence ID" value="PCH37112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J4D0"/>
    <dbReference type="OMA" id="IVIMAEP"/>
    <dbReference type="OrthoDB" id="2800435at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013763104" evidence="2">
        <location>
            <begin position="32"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH37112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="229" mass="26540" checksum="A3037343DF1F4AF1" modified="2018-01-31" version="1" fragment="single">KYMWRGRFVWTRVLFWMVRVHLLYETGRLDATPLDASLFVPVTGTDLIDSCTFWFKWFLYANIVTRVTISGILIMRVYVMYGCRRDLLIILCTLFVVELIAETVIFVESLLFVLALVKFIQQLRPETHTPRLMAVLLMDSLLYFIGALCAILINFIAWMNEVQLDMSVHRLTVAVNSLLGCHMLVRPIRLKRLQSILVTLTAEHPKRRKNSPPILYNRSVGIVARGHDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J5E1</accession>
    <name>A0A2H3J5E1_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">PCI-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">WOLCODRAFT_140874</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Phaeolaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9 10">MD-104</strain>
        </source>
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        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
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    </comment>
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    </dbReference>
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        <location>
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        <location>
            <begin position="1"/>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
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                <person name="St John F."/>
                <person name="Stenlid J."/>
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                <person name="Wiebenga A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-KW"/>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="278" mass="30510" checksum="C3A203885303AC29" modified="2018-01-31" version="1">MSRVVIVTGCSEGGIGYSLCLEFASRGCKVYATARRPESMDSLTHKNIERLKLDVTDDANVADVVKTVVEREGRIDILFNNAGVECTGPLAEMPLDRIAQSFDANVFSVIRMVRAVFPHMAARKSGTIVNMGSIAGEIATPWGGVYSATKACLKSISETLYMECAPFNISVVHLTPGGVKSNIATNYLNKFSCLPQPDSFYGGYLDSMVQHIGLSRSPHAMPSEEFARRVVTAVLQKNPPRYMTLASASTIFQILQWLPRGFVLWLFWKLLVGKPAHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
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    <name>A0A2H3J5Y1_WOLCO</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1221748"/>
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            <strain evidence="2 3">MD-104</strain>
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        </location>
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        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="118" mass="12785" checksum="CB9022358F385345" modified="2018-01-31" version="1" fragment="single">RLTCFRALGTLFMFELAIAPGHAPVTRGPYARVYLKLGGTSAAALGRGAWLGECALAPRPTGPGTLLAWAALALCTAKVAYALRSTNRRVRTEDRALRAATSVEWEAYAERVQWRLVP</sequence>
</entry>
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    <accession>A0A2H3J7A1</accession>
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        <recommendedName>
            <fullName evidence="4 14">Dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
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        </recommendedName>
    </protein>
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        <name evidence="17" type="ORF">WOLCODRAFT_135862</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
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            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
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            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Protein modification; protein glycosylation.</text>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Endoplasmic reticulum membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the glycosyltransferase 39 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="4 14"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0005789">
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="entry name" value="Protein O-mannosyl-transferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="ArnT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="PMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032421">
        <property type="entry name" value="PMT_4TMC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050:SF46">
        <property type="entry name" value="PROTEIN O-MANNOSYL-TRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PMT_4TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="8" id="KW-0677">Repeat</keyword>
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    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="296"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="350"/>
            <end position="369"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="713"/>
            <end position="734"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="740"/>
            <end position="759"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="771"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="16">
        <location>
            <begin position="403"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="16">
        <location>
            <begin position="469"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="16">
        <location>
            <begin position="536"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PCH37811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="817" mass="94049" checksum="03D6D86B1751CEC7" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J842</accession>
    <name>A0A2H3J842_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_136046</name>
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    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467942">
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    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="393"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="397"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH38111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="450" mass="49383" checksum="6C9507973CCC681A" modified="2018-01-31" version="1">MEPWVLFRKFRTVLFAVISVISLLWAILLSVYLAREWKHGEKAQRIIVLLMICGNVFTSVLLYLMIVVMFQLWLDFSRIVFLFALHFVLAVLLSIFGHKFDCTVFGSRDTCDSVYDFALFIVWSMVTLFVVHAVVLGVMSRIPRPEPDMTEKLVSETSSEKPRGDIEENIEPDPDSPDSVVSQAERVQAAPARLVVMEGASRPVYIPPPPRKLLLADSARGSYGTMDPTDYLPTLPYGASSLEGFMTSSSPAPSYTSQDPVFSRPPQSESRFHPRPFHLDQNALSRSGSVSSVATVDSVISAYNQLPDSNAPARPTLAVVAQHRRSASLGARSFDTLPPQLRPGTPLGNRSPSPALNAFAAQVHTRTRTATLDSIHSVVPSLLFMEGEASPARAHMRANSNSSTRSNFSSSSLSRQPTVKLHLPNPYDTADEPPVPQRSGSLDLTTGSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J8C1</accession>
    <name>A0A2H3J8C1_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mannosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WOLCODRAFT_96030</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the third mannose to Man2-GlcN-acyl-PI during GPI precursor assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 22 family. PIGB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH37875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J8C1"/>
    <dbReference type="STRING" id="742152.A0A2H3J8C1"/>
    <dbReference type="OMA" id="HHMVFNN"/>
    <dbReference type="OrthoDB" id="416834at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005599">
        <property type="entry name" value="GPI_mannosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760:SF4">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03901">
        <property type="entry name" value="Glyco_transf_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013951063" description="Mannosyltransferase" evidence="11">
        <location>
            <begin position="19"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="169"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="208"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
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            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="352"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PCH37875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="539" mass="60898" checksum="8E9A55C68A71A528" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J8U2</accession>
    <name>A0A2H3J8U2_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_136372</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH38630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J8U2"/>
    <dbReference type="STRING" id="742152.A0A2H3J8U2"/>
    <dbReference type="OMA" id="RNTWYFI"/>
    <dbReference type="OrthoDB" id="5537330at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052999">
        <property type="entry name" value="PTS1_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28180">
        <property type="entry name" value="CONSERVED MITOCHONDRIAL PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28180:SF2">
        <property type="entry name" value="PEROXISOMAL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH38630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="245" mass="26527" checksum="5146166BF32E3252" modified="2018-01-31" version="1">MAALATDSFLSQLKSLYPSTGAATPDELLSQPWYLVAAVAFSASRKADAVPVVFEFALNELKKAQAGEEPERALAQRIALASKFREALLQSCLLSGVPRVIESLIALRNVMPEELRGKEVLRDRTKTIVDYERSGEQLFRAMYRDTADNVQGLLDSAYADLGWFCNTVGYGITYGGANVLSQVETSYAIVAALISIDAPRQSTWHLANARNGGATLEEAKAVREIAMKVAGVAGVTWQDGVPEVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J952</accession>
    <name>A0A2H3J952_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">RNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WOLCODRAFT_136443</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
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                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="PCH35489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J9S3"/>
    <dbReference type="STRING" id="742152.A0A2H3J9S3"/>
    <dbReference type="OMA" id="PMEWILE"/>
    <dbReference type="OrthoDB" id="5424209at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH35489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="567" mass="62273" checksum="3636267105749ECA" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J9U4</accession>
    <name>A0A2H3J9U4_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_167736</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467943">
        <property type="protein sequence ID" value="PCH38976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J9U4"/>
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        <location>
            <begin position="208"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH38976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="253" mass="27717" checksum="6D0B6CB59F0F8996" modified="2018-01-31" version="1">MGEQVSRTLEVAKIFIGDPFTAFSAVRVYALRDRGWPLAVLTFMLAMARVAINLIIEGDSFIATSSGNVIQFTRIPTLLQSIRGSIQSLIDIWDLIVEINDEVAIYGGVSSIVSDAIVILTTWRRAGVSERQIAEFGGNMSLLQILIRDATFTTSLAVFEPLVSSITPILISRLMIHLQEACFDPDDPSGIHSTARAGMQSTIQFQSPVRGSEQAIASTFDGLSENREMDSAELQMQEQTAEPDCNEDQLEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JAU3</accession>
    <name>A0A2H3JAU3_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Histone-lysine N-methyltransferase, H3 lysine-79 specific</fullName>
            <ecNumber evidence="2 11">2.1.1.360</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 11">Histone H3-K79 methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">WOLCODRAFT_61913</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Histone methyltransferase that specifically trimethylates histone H3 to form H3K79me3. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>L-lysyl(79)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(79)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60328"/>
            <dbReference type="Rhea" id="RHEA-COMP:15549"/>
            <dbReference type="Rhea" id="RHEA-COMP:15552"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.360"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="11">Ubiquitination of histone H2B to form H2BK123ub1 is required for efficient DOT1 methyltransferase activity on histone H3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="11">In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.360" evidence="2 11"/>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH33057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JAU3"/>
    <dbReference type="STRING" id="742152.A0A2H3JAU3"/>
    <dbReference type="OMA" id="PIMCLES"/>
    <dbReference type="OrthoDB" id="443402at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140956">
        <property type="term" value="F:histone H3K79 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000033">
        <property type="entry name" value="Histone-lysine N-methyltransferase, H3 lysine-79 specific"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025789">
        <property type="entry name" value="DOT1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030445">
        <property type="entry name" value="H3-K79_meTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21451">
        <property type="entry name" value="HISTONE H3 METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21451:SF0">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08123">
        <property type="entry name" value="DOT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51569">
        <property type="entry name" value="DOT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DOT1" evidence="13">
        <location>
            <begin position="147"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="470"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="108"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="477"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU271113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PCH33057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="489" mass="53445" checksum="20611D737185A9AC" modified="2018-01-31" version="1">MENLRRLRTNTDFRNLDDPADKSFEPHPTDYPVTELEYPNTGASERFILVVPKDKDHYNPIMCLENTLHTIIEYYLTPAQRALFGTLPSNNLVDDDCPVPPPLIPHISTSEFTETSSPPSVISSASSPASSLLSESSSASSVSSATSLSSLSSLSSVSSLSSLASLSSLSALASHASQPSPSHPPSVNYLRLFQRAINKQDGPLFLKVMDAINALLRLLKYPPLPLDPFAPAPPNNLCAAVATWPRIPEKVLTRIVDETYQRAVGPHVAELKRYSAFSSEVYGELMPSFVAQIIATTGLGSDSLFVDLGSGVGNVVLQASLQTGCQSFGVEIMPDPAKIARSQLEQCKMRCRMWGVSMGEVELEEGDMLKSKRVDELVPKADVVLVNNKVFLESLNEAIRPKFLDLKEGAVVVSLKPFVSSQRLTGRNLDDISAIFQVTERPYYPGSVSWGNGSGSYFLHRVDREGYADRKAEFESSRNGSSRGTRSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JAU8</accession>
    <name>A0A2H3JAU8_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_19582</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467832">
        <property type="protein sequence ID" value="PCH34788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JAU8"/>
    <dbReference type="OrthoDB" id="2798900at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013702376" evidence="1">
        <location>
            <begin position="23"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH34788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="125" mass="13225" checksum="0B6C3C31B0AC1BB6" modified="2018-01-31" version="1">MVSNLILAAGAVALSTMSGAFAVPLASTATVNPSCPALYTTTYTQTLSIIAPSTTGPLATTTVTDTLTSYPVYATTEIGTSTFSGTVWVDPSEVPTTTFYTTTWTEVYGYTNWYNSPSWPSDCVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JBS6</accession>
    <name>A0A2H3JBS6_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein mL40</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WOLCODRAFT_63877</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL40 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH34124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JBS6"/>
    <dbReference type="STRING" id="742152.A0A2H3JBS6"/>
    <dbReference type="OMA" id="ERAWFLH"/>
    <dbReference type="OrthoDB" id="2098203at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019192">
        <property type="entry name" value="Ribosomal_mL40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042831">
        <property type="entry name" value="Ribosomal_mL40_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39150">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L28, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39150:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09812">
        <property type="entry name" value="MRP-L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PCH34124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="189" mass="21814" checksum="1113E58B07CBDCF6" modified="2018-01-31" version="1">MSASLLALREILHPLRAFQASVRSYSVRKEVSNGDPRLETIRRVLYPSTLRNKPAPTGTWRPDIGRRLQRAIPSVQAHETIERAWLLRQRHVRRARQAELARKFACMQHAMDVLRELDPKLYAGANKEEDPRTRSQAEVALSKTLRGPQRKALEARVRGLFPRELRIPTDTPSPTGWNYDWTPIIPRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JBZ1</accession>
    <name>A0A2H3JBZ1_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Lethal giant larvae (Lgl)-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WOLCODRAFT_113329</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH34194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JBZ1"/>
    <dbReference type="STRING" id="742152.A0A2H3JBZ1"/>
    <dbReference type="OMA" id="AWSGFPN"/>
    <dbReference type="OrthoDB" id="19944at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045159">
        <property type="term" value="F:myosin II binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15873">
        <property type="entry name" value="R-SNARE_STXBP5_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013905">
        <property type="entry name" value="Lgl_C_dom"/>
    </dbReference>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
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            <dbReference type="DOI" id="10.1126/science.1221748"/>
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            <dbReference type="DOI" id="10.1126/science.1221748"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4 5">MD-104</strain>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Glycogen synthase participates in the glycogen biosynthetic process along with glycogenin and glycogen branching enzyme. Extends the primer composed of a few glucose units formed by glycogenin by adding new glucose units to it. In this context, glycogen synthase transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose = [(1-&gt;4)-alpha-D-glucosyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18549"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9587"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.11"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:18550"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyltransferase 3 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.11" evidence="8"/>
    <dbReference type="EMBL" id="KB467832">
        <property type="protein sequence ID" value="PCH34714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JDD9"/>
    <dbReference type="STRING" id="742152.A0A2H3JDD9"/>
    <dbReference type="OMA" id="RDVRNHI"/>
    <dbReference type="OrthoDB" id="6335297at2759"/>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004373">
        <property type="term" value="F:alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03793">
        <property type="entry name" value="GT3_GSY2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000014">
        <property type="entry name" value="Glycogen [starch] synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000045">
        <property type="entry name" value="Glycogen [starch] synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008631">
        <property type="entry name" value="Glycogen_synth"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10176:SF3">
        <property type="entry name" value="GLYCOGEN [STARCH] SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10176">
        <property type="entry name" value="GLYCOGEN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05693">
        <property type="entry name" value="Glycogen_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="3 8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 9" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00043883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PCH34714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="735" mass="83133" checksum="7D1A9FFCBFBB8ABE" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JDI3</accession>
    <name>A0A2H3JDI3_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_146992</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468020">
        <property type="protein sequence ID" value="PCH39625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JDI3"/>
    <dbReference type="STRING" id="742152.A0A2H3JDI3"/>
    <dbReference type="OMA" id="VARHIEF"/>
    <dbReference type="OrthoDB" id="2735181at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH39625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="481" mass="54273" checksum="C1FF233CA611BF17" modified="2018-01-31" version="1">MPLLSLNHDVLYEVLAQTDYQSAMRLSMVSRDTHELGIRHALTRVTLSRSQKQVSAFCKFVLADPANRLPNLRELTIESGAFGVARHIEFQRKGDFSAAADLADLLEHADQLRRLSLACFEDLIVTEPRIGAALCALPNLVDLGLHQCGQSSMSIFPLLRSQPRKIAFTSLFNRRLPTFFHRLQGLKQLETLELSHLDLSDGSQPHAEIHEIPSLPTIRSLSLRGCTARMSLFVHAMPHLRSLSIADVFTKVEDHADYTKRGCWAGLTCLRGNVSDFRYWKVRCPVRWLQLDLTAYHYHDALDVIQRTSPVALSLPVETRADAPFWTGVRTAAPRLRYLEVCLDEVKGRSVEWWLRDWLTGEQQNICPAMAILPIVAICLCVRKTQWIGADTDQGIPDPRTDAAFRALREGVKGALPSLHFIALALATKGENPFERRHRAAPVWWRVHSSSSGRTLDFIPDDKSGSLRDHLIFKDSIPKMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JDJ9</accession>
    <name>A0A2H3JDJ9_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_68329</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468053">
        <property type="protein sequence ID" value="PCH40310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JDJ9"/>
    <dbReference type="STRING" id="742152.A0A2H3JDJ9"/>
    <dbReference type="OrthoDB" id="3172935at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013769870" evidence="1">
        <location>
            <begin position="18"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH40310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="205" mass="23311" checksum="708696EEDF979279" modified="2018-01-31" version="1" fragment="single">RCFLHIINLACQAVLEAITDTPHIEYDAADFIPKGPTPRSFTDAINRDPISTLRSLIHYFASVLRMMGQSNLQLIRDVKTRCDPKHLWVIPQHLNPCSQFLESSDNEDMHKFRLNDIEWEALEAFHLILQVPHAFQQVLSYESTPTLGHTVPAYEAMENAWKQLQAQNTQLSGIIQCGLGKLDQYRTRADRVPAYVLAMGKIAIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JDM7</accession>
    <name>A0A2H3JDM7_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_150033</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
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                <person name="de Vries R.P."/>
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            <dbReference type="DOI" id="10.1126/science.1221748"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>(6R)-NADHX = (6S)-NADHX</text>
            <dbReference type="Rhea" id="RHEA:32215"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:64075"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 10">
            <text>(6R)-NADPHX = (6S)-NADPHX</text>
            <dbReference type="Rhea" id="RHEA:32227"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:64077"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="10">Binds 1 potassium ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the NnrE/AIBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="5.1.99.6" evidence="3 10"/>
    <dbReference type="EMBL" id="KB468053">
        <property type="protein sequence ID" value="PCH40115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JF01"/>
    <dbReference type="STRING" id="742152.A0A2H3JF01"/>
    <dbReference type="OMA" id="SMFRGRY"/>
    <dbReference type="OrthoDB" id="10064708at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052856">
        <property type="term" value="F:NAD(P)HX epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10260:FF:000005">
        <property type="entry name" value="NAD(P)H-hydrate epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10260">
        <property type="entry name" value="YjeF N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01966">
        <property type="entry name" value="NADHX_epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004443">
        <property type="entry name" value="YjeF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036652">
        <property type="entry name" value="YjeF_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032976">
        <property type="entry name" value="YJEFN_prot_NAXE-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00197">
        <property type="entry name" value="yjeF_nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13232">
        <property type="entry name" value="NAD(P)H-HYDRATE EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13232:SF10">
        <property type="entry name" value="NAD(P)H-HYDRATE EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03853">
        <property type="entry name" value="YjeF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64153">
        <property type="entry name" value="YjeF N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51385">
        <property type="entry name" value="YJEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8 10" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 10" id="KW-0630">Potassium</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YjeF N-terminal" evidence="11">
        <location>
            <begin position="11"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="62"/>
            <end position="66"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="134"/>
            <end position="140"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PCH40115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="244" mass="26550" checksum="21C119BD2C24D8A6" modified="2018-01-31" version="1">MSVRYLTAKLAQQIDEQLMSAAGAFSLDQLMELAGLACAQTLAKVYSKEKYPRVLVCCGPGNQGGDGLVAARHLGMFGYQPTIWMPKPGSKDIYKRLKTQCDNMKIQTLAPTEETHSLRDALASSDVILDAIFGFSFKPPVRAPFDAALPLLSASGLPIVSVDIPSGWDVEEGNAEGVGLNPDVLISLTAPKEGVRQFTRRHFLGGRFVPKLMEEQFALNLPEYPGFDQIVELPQAKESGPQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JF09</accession>
    <name>A0A2H3JF09_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_140806</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467920">
        <property type="protein sequence ID" value="PCH37319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JF09"/>
    <dbReference type="STRING" id="742152.A0A2H3JF09"/>
    <dbReference type="OrthoDB" id="3270368at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="201"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH37319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="508" mass="55845" checksum="AD049DA0C5BC4A3D" modified="2018-01-31" version="1">MIDYGALPESDPFLSTRNTSSPLTALSARRKKANNKPAPESKAPQSSTTKGRPHKAKLWKTKPSPPDPIVYQGASDDDPLCDSHELSDTFVEDEPVEETKENQSEVKIETHAKHVVPALAASASTTDKRRVEMSTPALQEKAHPLSGSTNIAKSTSKKRKIAPWANLTSEAPHRSANVDNSTSGVPGVHHEETIQPTLNTSGRPSLSKKSMSSSASESLLTGSDISEVANKAIHATIADSILGTNTTPRSDRMHSPAPLVIPSPEKLEQTDFELTEVTSTPIGKVVEVDDRAGDSVSTRKTHPRHSVTFAPVVEEREPSPELNFEIGSRSQPTSLSPYKRERATVSMGQLLQDIEHEPFIGRRERDSFQKTNITGAGNRSRRKEAAANVQDIEDVLWELHQAIFDKITDRFDSVREEVRIDRSAILRKAAQDLMQMRADSVAHFNRLIDLEAEYASSGRAVTGSLEEWLRANEGICCKIEETIKSIDRTTLVGRMPVVLVEIPVSLRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JFL1</accession>
    <name>A0A2H3JFL1_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GDP-mannose 4,6-dehydratase</fullName>
            <ecNumber evidence="3">4.2.1.47</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WOLCODRAFT_140910</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD-104</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.47" evidence="3"/>
    <dbReference type="EMBL" id="KB467931">
        <property type="protein sequence ID" value="PCH37529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JFL1"/>
    <dbReference type="STRING" id="742152.A0A2H3JFL1"/>
    <dbReference type="OMA" id="HWQTVNY"/>
    <dbReference type="OrthoDB" id="10253554at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008446">
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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</entry>
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    <accession>A0A2H3JGA0</accession>
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        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
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            <taxon>Phaeolaceae</taxon>
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        </lineage>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
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                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
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        <source>
            <dbReference type="EMBL" id="PCH40931.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
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</entry>
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    <accession>A0A2H3JGV9</accession>
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        <submittedName>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD-104</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GrpII_AminoAcid_Decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
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        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42735">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42735:SF4">
        <property type="entry name" value="PYRIDOXAL PHOSPHATE-DEPENDENT DECARBOXYLASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PCH35944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="1061" mass="117493" checksum="433FCAE6E478814E" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JGW8</accession>
    <name>A0A2H3JGW8_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">WOLCODRAFT_24513</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
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        <source>
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        <source>
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        <source>
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            <dbReference type="EMBL" id="PCH41616.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
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</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JHU0</accession>
    <name>A0A2H3JHU0_WOLCO</name>
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        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
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        <name evidence="7" type="ORF">WOLCODRAFT_137202</name>
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        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7 8">MD-104</strain>
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        <subcellularLocation>
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    </dbReference>
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    </dbReference>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH41125.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
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</entry>
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            <fullName evidence="15">Cytochrome P450</fullName>
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    <organism evidence="15 16">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">MD-104</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468124">
        <property type="protein sequence ID" value="PCH41910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JI83"/>
    <dbReference type="STRING" id="742152.A0A2H3JI83"/>
    <dbReference type="OMA" id="HRVCPGD"/>
    <dbReference type="OrthoDB" id="1055148at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF2">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ALNH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PCH41910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="209" mass="22996" checksum="670A18F9677A9AC5" modified="2018-01-31" version="1">MVHRGSSPISVAGSAFEAGTDNNPATVLGFLVVMLHNPDIMRKAQTELDRVLGPEGYTPPSFKNLQDLPYCVALVKEVFRWMPVAPVGSLYLSLKDDTYQGYRIAASTTIVANIWAVHHNETNYPDPFTFRPERFIPAADGKVEAEHLYEGHYGFGFGRRACPGQYIASKSVWIGVVHLLWAFDISPPIDEYGAAILPDTTAVRDGLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JJC7</accession>
    <name>A0A2H3JJC7_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">E3 ubiquitin ligase complex SCF subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WOLCODRAFT_114329</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Essential component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the SKP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH37858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JJC7"/>
    <dbReference type="STRING" id="742152.A0A2H3JJC7"/>
    <dbReference type="OMA" id="TECPTEC"/>
    <dbReference type="OrthoDB" id="2342932at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016897">
        <property type="entry name" value="SKP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001232">
        <property type="entry name" value="SKP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036296">
        <property type="entry name" value="SKP1-like_dim_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016072">
        <property type="entry name" value="Skp1_comp_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016073">
        <property type="entry name" value="Skp1_comp_POZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11165">
        <property type="entry name" value="SKP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01466">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03931">
        <property type="entry name" value="Skp1_POZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028729">
        <property type="entry name" value="E3_ubiquit_lig_SCF_Skp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00512">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81382">
        <property type="entry name" value="Skp1 dimerisation domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="SKP1 component POZ" evidence="6">
        <location>
            <begin position="2"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="SKP1 component dimerisation" evidence="5">
        <location>
            <begin position="98"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="126"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR028729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PCH37858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="155" mass="17398" checksum="956D46E1AD6B7C48" modified="2018-01-31" version="1">MLNIVTSDGQRLALERDVAEQAGLLRDFAQNQTDEDVPVPTITSGIFRKILDYFEHYGNEPVDAGTRRRDQQWEREYLAIDHGTLFNIITAANYLGAKPLLSMCTQEVADRIVGKTPQEIRQMFNIQNNSSPGQPTECPTECPTECPAECPTPDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JJJ4</accession>
    <name>A0A2H3JJJ4_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="10">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">WOLCODRAFT_109252</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="10"/>
    <dbReference type="EMBL" id="KB467898">
        <property type="protein sequence ID" value="PCH36854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JJJ4"/>
    <dbReference type="STRING" id="742152.A0A2H3JJJ4"/>
    <dbReference type="OMA" id="YDKMFER"/>
    <dbReference type="OrthoDB" id="10259640at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17941">
        <property type="entry name" value="DEADc_DDX10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025313">
        <property type="entry name" value="SPB4-like_CTE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13959">
        <property type="entry name" value="CTE_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01178">
        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="14">
        <location>
            <begin position="54"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="85"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="275"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="512"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="624"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="694"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="9">
        <location>
            <begin position="54"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="559"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="640"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="694"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="718"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="760"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="781"/>
            <end position="792"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PCH36854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="810" mass="90157" checksum="E7999D38BF2E9346" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JJV7</accession>
    <name>A0A2H3JJV7_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Methionine aminopeptidase</fullName>
            <ecNumber evidence="11">3.4.11.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WOLCODRAFT_152494</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 11">Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="11">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="9">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with zinc, cobalt, manganese or divalent iron ions. Has high activity with zinc; zinc cofactor is transferred into the active site region by the ZNG1 zinc chaperone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Associates with the 60S ribosomal subunit of the 80S translational complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="11"/>
    <dbReference type="EMBL" id="KB468124">
        <property type="protein sequence ID" value="PCH42462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JJV7"/>
    <dbReference type="STRING" id="742152.A0A2H3JJV7"/>
    <dbReference type="OMA" id="INQGTHQ"/>
    <dbReference type="OrthoDB" id="3209743at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004239">
        <property type="term" value="F:initiator methionyl aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01086">
        <property type="entry name" value="MetAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000010">
        <property type="entry name" value="Methionine aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01974">
        <property type="entry name" value="MetAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002467">
        <property type="entry name" value="Pept_M24A_MAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031615">
        <property type="entry name" value="Zfn-C6H2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00500">
        <property type="entry name" value="met_pdase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43330">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43330:SF7">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15801">
        <property type="entry name" value="zf-C6H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52013">
        <property type="entry name" value="ZF_C6H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JJZ0</accession>
    <name>A0A2H3JJZ0_WOLCO</name>
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        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
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    <gene>
        <name evidence="8" type="ORF">WOLCODRAFT_146212</name>
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    <organism evidence="8 9">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Phaeolaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
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                <person name="Sabat G."/>
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                <person name="Stenlid J."/>
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                <person name="Syed K."/>
                <person name="Tsang A."/>
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                <person name="Martin F."/>
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        <property type="entry name" value="MFS_trans_sf"/>
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        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G01812)-RELATED"/>
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    </dbReference>
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        <property type="entry name" value="MFS_1"/>
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            <end position="84"/>
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    </feature>
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    </feature>
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        <source>
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        </source>
    </evidence>
    <sequence length="526" mass="58950" checksum="B325FACE6DA074A7" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
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                <person name="Kuo A."/>
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                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
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                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
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                <person name="St John F."/>
                <person name="Stenlid J."/>
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                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
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                <person name="Cullen D."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
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            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
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                <person name="Barry K."/>
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                <person name="Martinez A.T."/>
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            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH40703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JLH3"/>
    <dbReference type="STRING" id="742152.A0A2H3JLH3"/>
    <dbReference type="OMA" id="DWAHKLH"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050228">
        <property type="entry name" value="Carboxylesterase_BioH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43194">
        <property type="entry name" value="HYDROLASE ALPHA/BETA FOLD FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43194:SF2">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN LPX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="86"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH40703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="340" mass="37003" checksum="E5056E4FB40C1BAD" modified="2018-01-31" version="1">MRSSSAPVIQWFLLALPAAVFFGYFLTAFPHRCTSTPAQPSLASLPADSPSWDIYPEDFYEGGAYARLPQGTVRYWLIGPENGERIVLIHGLSVPAIIWKEIAPQLAQNGFRVLLYDLYGRGYSDAPQTTYDVNLYTTQLALLMQYVGWSHAHIAGVSMGGGIAAAFSAQFPHLVTDRLALVACTGLLNPSDLSRTSKFLSSPIVQLVASSYPFRRYLQYLASGKSAREDPIAELVRIQSAYLPGFNPAIASSLRDGPIRDLAPSFAALGQRHANVVVIWGTADTVVPYRSAARVRAHIPDAQMVTIDGGGHDILVSHPATVGRALVRFFSDKRGQAARQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JLH4</accession>
    <name>A0A2H3JLH4_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Deoxyuridine 5'-triphosphate nucleotidohydrolase</fullName>
            <shortName evidence="6">dUTPase</shortName>
            <ecNumber evidence="6">3.6.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">dUTP pyrophosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WOLCODRAFT_74176</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in nucleotide metabolism via production of dUMP, the immediate precursor of thymidine nucleotides, and decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>dUTP + H2O = dUMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10248"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61555"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="3.6.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 6">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the dUTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.23" evidence="6"/>
    <dbReference type="EMBL" id="KB468135">
        <property type="protein sequence ID" value="PCH42731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JLH4"/>
    <dbReference type="STRING" id="742152.A0A2H3JLH4"/>
    <dbReference type="OrthoDB" id="419889at2759"/>
    <dbReference type="UniPathway" id="UPA00610">
        <property type="reaction ID" value="UER00666"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004170">
        <property type="term" value="F:dUTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006226">
        <property type="term" value="P:dUMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046081">
        <property type="term" value="P:dUTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07557">
        <property type="entry name" value="trimeric_dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008181">
        <property type="entry name" value="dUTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029054">
        <property type="entry name" value="dUTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033704">
        <property type="entry name" value="dUTPase_trimeric"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11241">
        <property type="entry name" value="DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11241:SF0">
        <property type="entry name" value="DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00692">
        <property type="entry name" value="dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51283">
        <property type="entry name" value="dUTPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="dUTPase-like" evidence="7">
        <location>
            <begin position="2"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PCH42731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="77" mass="8744" checksum="4345C123C959F364" modified="2018-01-31" version="1">MIDTGLKILFPYGMYSQLISQSSMAKKSLMVAGGIINWDYRGEVKVMIHNLSQEPYEVKAKDKIAQLLVHQQPHPEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JLR1</accession>
    <name>A0A2H3JLR1_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="6">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WOLCODRAFT_25749</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="6"/>
    <dbReference type="EMBL" id="KB468135">
        <property type="protein sequence ID" value="PCH43146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JLR1"/>
    <dbReference type="STRING" id="742152.A0A2H3JLR1"/>
    <dbReference type="OMA" id="FKSDAEY"/>
    <dbReference type="OrthoDB" id="333239at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
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        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 14"/>
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    </dbReference>
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            <begin position="362"/>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH43146.1"/>
        </source>
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        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="531" mass="57858" checksum="6028937C2664780E" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JLW2</accession>
    <name>A0A2H3JLW2_WOLCO</name>
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        <recommendedName>
            <fullName evidence="9">Elongation factor 1-beta</fullName>
        </recommendedName>
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        <name evidence="7" type="ORF">WOLCODRAFT_25778</name>
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        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD-104</strain>
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        <text evidence="1 4">Belongs to the EF-1-beta/EF-1-delta family.</text>
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        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="EF-HAND AND COILED-COIL DOMAIN-CONTAINING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ELONGATION FACTOR 1-BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <feature type="domain" description="Elongation factor 1 beta central acidic region eukaryote" evidence="6">
        <location>
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        </location>
    </feature>
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        </location>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH43192.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="215" mass="23545" checksum="2A8FFC9D1C409655" modified="2018-01-31" version="1">MSLDLAKLEAHLATRSYVEGYTPSQADVHVFKAISSTPNVSAYPHVARWYTHISTYAAEHSSLPGSSTAGEAFFGSAAAAAAEEKEDDDDEVDLFGSDDDEDAEAERIKAERVAAYNAKKANKPKTVAKSVVTFEVKPWDDETDMAKLEECVRSIEMDGLVWGASKLVPIGYGIRKLQITLVVEDELVSMDDLQEKVAEFDDYVQSSDIAAMQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JMS2</accession>
    <name>A0A2H3JMS2_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_158567</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467954">
        <property type="protein sequence ID" value="PCH39038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JMS2"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH39038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="107" mass="12298" checksum="10AC212F01F86CE8" modified="2018-01-31" version="1">MHRKASALQKITQLQSGSLQIWAVLLLEGRPNTARAEHTTSSYTPRLMLIKRATAVVHEVRLQSIITLKYPQSMIDHREEYPISPVEVSNFYGLSEPHDPDEHFFSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JMV0</accession>
    <name>A0A2H3JMV0_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">V-type proton ATPase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WOLCODRAFT_98356</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments. This subunit is a non-integral membrane component of the membrane pore domain and is required for proper assembly of the V0 sector. Might be involved in the regulated assembly of V1 subunits onto the membrane sector or alternatively may prevent the passage of protons through V0 pores.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1).</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the V-ATPase V0D/AC39 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468053">
        <property type="protein sequence ID" value="PCH40139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JMV0"/>
    <dbReference type="STRING" id="742152.A0A2H3JMV0"/>
    <dbReference type="OMA" id="MTYGYMI"/>
    <dbReference type="OrthoDB" id="10250083at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.50:FF:000002">
        <property type="entry name" value="V-type proton ATPase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1690.10:FF:000003">
        <property type="entry name" value="V-type proton ATPase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.50">
        <property type="entry name" value="ATP synthase (C/AC39) subunit, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1690.10">
        <property type="entry name" value="V-type ATP synthase subunit C domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036079">
        <property type="entry name" value="ATPase_csu/dsu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002843">
        <property type="entry name" value="ATPase_V0-cplx_csu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016727">
        <property type="entry name" value="ATPase_V0-cplx_dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035067">
        <property type="entry name" value="V-type_ATPase_csu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044911">
        <property type="entry name" value="V-type_ATPase_csu/dsu_dom_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11028">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT AC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01992">
        <property type="entry name" value="vATP-synt_AC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018497">
        <property type="entry name" value="V-ATP_synth_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103486">
        <property type="entry name" value="V-type ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00059115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR018497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PCH40139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="371" mass="41610" checksum="E83A8E1B3C4E7B6A" modified="2018-01-31" version="1">MEALFFNVNTGFLEGIVRGYKAGLLTQNQYNNLTQCESIEDLRTQLSATDYGNFLANEPLPISTSTIAEKATQLLVDQFNYLRSNAVEPLSKFFDYITYAYMIDNVILLITGTLHERNTQELLERCHPLGVFETLPALCVATNVEELYRTALIETPLAPYFRDCLSASDLDDLNIEIIRNTLYKAYLEDFYAFCSSLGGPTADVMTRLLAFEADRRSINIAINSFGTELSKERRAKLFPTIGRLFPAGNNALARADDIEQVRQACDGVAEYRAFFDSGSGPGGARGQNGGASESTAHLLGDLDTGGAAELEDRFFAYEVHLNKLAFLQQFQYGVFYAYMKLKEQEIRSMTWIAECIAQDARDRIQDYIPTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JN68</accession>
    <name>A0A2H3JN68_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WOLCODRAFT_153678</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468146">
        <property type="protein sequence ID" value="PCH43626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JN68"/>
    <dbReference type="STRING" id="742152.A0A2H3JN68"/>
    <dbReference type="OMA" id="HYANNAT"/>
    <dbReference type="OrthoDB" id="2410195at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012967">
        <property type="entry name" value="COMT_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF2">
        <property type="entry name" value="O-METHYLTRANSFERASE CICE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08100">
        <property type="entry name" value="Dimerisation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase dimerisation" evidence="5">
        <location>
            <begin position="76"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="4">
        <location>
            <begin position="262"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PCH43626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="453" mass="50581" checksum="CB0C238D849B25DB" modified="2018-01-31" version="1">MPASEKAQQLRALVRLISDAAEDIIKEWEVEDSAPPTSKDAPRLPSWELYNARRTFIGACGMGVDLVHDPQTRLTEVAASYMNSQALRVAAETRIADILDGVDPSEGLSIQKISQRVGIQDKDLTRVLRSLCTLHIFNEVKEDHYANNATSRYLVKNEHLRCWLLVHSAEAFSATEKLPAALYDSLQRSGNSLRKSAFQIAYGIDADFWHWLEEMVERPDGTLGPRPEREVWRTGMWGFGLQHIQAPAVCDDYPWNELGPCTVVDIGAGIGGMSLELAKRYPQLRFVVEDTAPVLLHAKAVWERELPDVIATGRVQLMAHNFFEAQPVKGADIYVLRHIFHDWDDSECVAILTHLRAAMEPSSLVLIADNVMHSTAGTPHLKAAPPPLPPNYGQAHTFANIHDLLMFVMFMGGERTAEQLDVLAAQAGLKVTKVWECRGLTSITELRRDDYTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JNY9</accession>
    <name>A0A2H3JNY9_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mitochondrial cytochrome c oxidase assembly factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WOLCODRAFT_65246</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the PET100 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH38354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JNY9"/>
    <dbReference type="STRING" id="742152.A0A2H3JNY9"/>
    <dbReference type="OMA" id="KGIKFWP"/>
    <dbReference type="OrthoDB" id="18175at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018625">
        <property type="entry name" value="Pet100"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33968">
        <property type="entry name" value="PROTEIN PET100 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33968:SF1">
        <property type="entry name" value="PROTEIN PET100 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09803">
        <property type="entry name" value="Pet100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PCH38354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="92" mass="10741" checksum="FC17CF1B51EA6846" modified="2018-01-31" version="1">MAGPNLEVFKFAVYVFFPVAMMLHYGDPDWYRRHVLTYKDHVFPPDERLVTSLPTDPNALREELAKIRARKAERRAEKARNEDNANGNEHTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JP23</accession>
    <name>A0A2H3JP23_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-chaperonin molecular chaperone ATPase</fullName>
            <ecNumber evidence="2">3.6.4.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WOLCODRAFT_23323</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.10" evidence="2"/>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH38384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JP23"/>
    <dbReference type="STRING" id="742152.A0A2H3JP23"/>
    <dbReference type="OMA" id="NIPPMQA"/>
    <dbReference type="OrthoDB" id="2401965at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10233">
        <property type="entry name" value="ASKHA_NBD_HSP70_HSPA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000014">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000026">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000004">
        <property type="entry name" value="Heat shock protein SSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000005">
        <property type="entry name" value="Heat shock protein ssb1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0346">Stress response</keyword>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="569"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PCH38384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="612" mass="67159" checksum="DD56797CF0034088" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JPC5</accession>
    <name>A0A2H3JPC5_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_159383</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
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                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
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                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
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                <person name="Martin R."/>
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                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
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                <person name="St John F."/>
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                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
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                <person name="Wiebenga A."/>
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            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">MD-104</strain>
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                <person name="Barry K."/>
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                <person name="Kallen N."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <accession>A0A2H3JR18</accession>
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        </source>
    </evidence>
    <sequence length="242" mass="26784" checksum="EC5C4A1FCCF17DCB" modified="2018-01-31" version="1">MGRRKIEIQPILHERNRSVTFLKRKNGLFKKAYELGVLCSVDVAVIIFEERPGHHVKLYQYCSGDVNSMVQRHLRFDGERDTKTPADFNSAKAEEAPDDDDDELDDDGKAQPRARRDAPARPAARVKAEGAGNGAVPIRPVPAAGTDASMTIDVSPPRPTPPRALTPRSSTTAPTRRRRGARPRSRSRRSGTARPRPRRGASRSRRSARGSTSCTACPRSRRSASRRSAARRPRTRTGSRST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JR22</accession>
    <name>A0A2H3JR22_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA-splicing endonuclease subunit Sen15 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WOLCODRAFT_131285</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEN15 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468053">
        <property type="protein sequence ID" value="PCH40198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JR22"/>
    <dbReference type="STRING" id="742152.A0A2H3JR22"/>
    <dbReference type="OMA" id="STDWIRT"/>
    <dbReference type="OrthoDB" id="10002170at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018593">
        <property type="entry name" value="tRNA-endonuc_su_Sen15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036167">
        <property type="entry name" value="tRNA_intron_Endo_cat-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28582">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28582:SF1">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09631">
        <property type="entry name" value="Sen15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53032">
        <property type="entry name" value="tRNA-intron endonuclease catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA-splicing endonuclease subunit Sen15" evidence="3">
        <location>
            <begin position="26"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PCH40198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="118" mass="13079" checksum="C0F0E60FE807F8EB" modified="2018-01-31" version="1">MQSHPSYPALSALLPKYPRSAGALFQTYNDLTLAQQWTDVEVIDLAPCSRGAFRGRRPKTEDDLCVIPCSLSESVSLAWLQDAFRELGHPPQVYLAINTEDSSIVYYKISPGIVKPPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JR25</accession>
    <name>A0A2H3JR25_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">G-alpha-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WOLCODRAFT_122907</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468146">
        <property type="protein sequence ID" value="PCH43955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JR25"/>
    <dbReference type="STRING" id="742152.A0A2H3JR25"/>
    <dbReference type="OMA" id="FQLAYAY"/>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007188">
        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000692">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF360">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0807">Transducer</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="125"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="125"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="140"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="393"/>
            <end position="396"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PCH43955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="495" mass="55035" checksum="A4B8C14B4BBBC1AD" modified="2018-01-31" version="1">MAVLPLDPPDPLSLATAPPRDESPADRWAREQREAQGRLISEQIDAQIKAEKLAMKKRGKPIKILLLGQSESGKSTTVKNFQLAYAYSSFLQERSAWRAVIHLNLVRSVNTILDSSEATLMPDLDLDADDEDEDDEDDASASAASTSSTLTDRHRALQLRLAPLRHVQRDLERSLGAATSDAPEYAGDAAPWARLEGGRGAREAFVTSRYGWKTALRRGDEAMSDGECEPQAQNAAEVIASCAEDMIALWTDSGVQAVLSRRKVKSRLEEGPGFLNDVARVAKRDYEPSDEDVVRARLRTMGVQEYRFKFERGPDAGRDWLLYDVGGARSSRHAWAPYFDDINAIIFLAPISCFDERLAEDRRVNRLQDSLLLWKAVCSSKLLRNVQLILFLNKCDLLQKKISRGVRVANSVPSYGDRPNDARSVAKYFRHQFKEVLVRQSPEKRTFYAYFTSVVDTKATAITVAAGMCSNSGLLSHVGVSCRLGQFVMGFSVAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JRF7</accession>
    <name>A0A2H3JRF7_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WOLCODRAFT_105577</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8 9">MD-104</strain>
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<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
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            <taxon>Agaricomycotina</taxon>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1221748"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="18 19">MD-104</strain>
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    </dbReference>
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        <property type="match status" value="1"/>
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    <keyword evidence="6 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="3"/>
            <end position="58"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
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        </location>
    </feature>
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        <location>
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        </location>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
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        </location>
    </feature>
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            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
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                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
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                <person name="Boyd A."/>
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                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
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            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">MD-104</strain>
        </source>
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            <dbReference type="EMBL" id="PCH42209.1"/>
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    <accession>A0A2H3JTV5</accession>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
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                <person name="Lundell T."/>
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                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
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                <person name="Wiebenga A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">MD-104</strain>
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</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JU27</accession>
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            <fullName evidence="7">APC amino acid permease</fullName>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Martinez A.T."/>
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                <person name="Benoit I."/>
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                <person name="Nagy L.G."/>
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                <person name="Ohm R.A."/>
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                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
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            <dbReference type="DOI" id="10.1126/science.1221748"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    </dbReference>
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        <property type="entry name" value="GABA-SPECIFIC PERMEASE"/>
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        <property type="match status" value="1"/>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
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        <name evidence="3" type="ORF">WOLCODRAFT_17982</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468135">
        <property type="protein sequence ID" value="PCH42859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JVD1"/>
    <dbReference type="STRING" id="742152.A0A2H3JVD1"/>
    <dbReference type="OrthoDB" id="2804159at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <begin position="45"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH42859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="241" mass="27839" checksum="B7F1E30D80BD6E1F" modified="2018-01-31" version="1">MGAVLPPTWRGKWFVNIGRLMEVLHSYNHGISTAFATKSQNYKKFLRLVHNLGYIHGDLSSSNVLLYKKHIRLVDWEYTKHIDDKSLHKILMGPANFMATEVDLQEYLFYKLQPEGDTHQPDEEVDEDEEESKSESGRDNDNDNDSEKPMLQPIPFLYLPLHDLESLWWMMACSIFNKTVANVKGTSATRPPAEDQVNYAKALFLIGNQRGLMLQSPNILWNHTWMLHVAIQPRAKTSTWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JVJ6</accession>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
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                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
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                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JVJ6"/>
    <dbReference type="Proteomes" id="UP000218811">
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013675629" description="Secreted protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH44013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="112" mass="12311" checksum="333CC809D9A42B2E" modified="2018-01-31" version="1">MCPSFLARLLSFKIGLLARTRPPVIVDKSQCANSIKLHFRNLEPKKPSAGRAPVHRPGTWIEGAWQCCVKTTTIVALGEDSAYCSHRRYTACGLSTLVWAASLASQMLRSPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JW01</accession>
    <name>A0A2H3JW01_WOLCO</name>
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        <recommendedName>
            <fullName evidence="3">B box-type domain-containing protein</fullName>
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        <lineage>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
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                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
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                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD-104</strain>
        </source>
    </reference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="E2_Ub-conjug_enz_C"/>
    </dbReference>
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        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31560">
        <property type="entry name" value="UPF0652 PROTEIN C16A11.03C-RELATED"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR31560:SF0">
        <property type="entry name" value="UPF0652 PROTEIN C22H10.08"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DUF2009"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="56"/>
            <end position="102"/>
        </location>
    </feature>
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            <begin position="30"/>
            <end position="43"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PCH40894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="635" mass="71121" checksum="72D6FF2655938DE0" modified="2018-01-31" version="1"> </sequence>
</entry>
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    <accession>A0A2H3JW18</accession>
    <name>A0A2H3JW18_WOLCO</name>
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        <recommendedName>
            <fullName evidence="15">DNA ligase</fullName>
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        <name evidence="20" type="ORF">WOLCODRAFT_133112</name>
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    <organism evidence="20 21">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">MD-104</strain>
        </source>
    </reference>
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        <reaction evidence="14 15">
            <text>ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + diphosphate.</text>
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        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the ATP-dependent DNA ligase family.</text>
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    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11 15" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="12 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 15 20" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ATP-dependent DNA ligase family profile" evidence="18">
        <location>
            <begin position="382"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="19">
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    <feature type="region of interest" description="Disordered" evidence="17">
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            <end position="897"/>
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        <location>
            <begin position="918"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
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            <end position="646"/>
        </location>
    </feature>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
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            <end position="966"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JWF5</accession>
    <name>A0A2H3JWF5_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_151099</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="188" mass="21731" checksum="B7A12220309B9653" modified="2018-01-31" version="1">MMQLLGMHYVRYNIQATPGECRLWHSSLALQAVMIYMLNALMYPSGNFLRELELTAKVTCWIYPGAESFDGNGSDDSYILSEDELDEPCATGDHQGIYFIGGIIEDYGEARDRQRRGEERGHGTYRLSNRQKVKEETLTYLYSIRSMNDLYKVFGFCCGFGEGPKTHPTWTRRHRNTLRLEHVRAEVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JYZ1</accession>
    <name>A0A2H3JYZ1_WOLCO</name>
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        <submittedName>
            <fullName evidence="5">GMC oxidoreductase</fullName>
        </submittedName>
    </protein>
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        <name evidence="5" type="ORF">WOLCODRAFT_25722</name>
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    <organism evidence="5 6">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD-104</strain>
        </source>
    </reference>
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        <cofactor evidence="1 3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
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        <property type="protein sequence ID" value="PCH43098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="742152.A0A2H3JYZ1"/>
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    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
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        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF78">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="276"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="18"/>
            <end position="19"/>
        </location>
        <ligand>
            <name>FAD</name>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="536"/>
            <end position="537"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH43098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="616" mass="67511" checksum="F4ED4BC2B947EEEE" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
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                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
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                <person name="Stenlid J."/>
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                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
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                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
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    <dbReference type="OrthoDB" id="3258311at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <source>
            <dbReference type="EMBL" id="PCH42304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="671" mass="76487" checksum="BF6CDC05AB0FF60E" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-05-03" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K097</accession>
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    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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    <organism evidence="1 2">
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    </organism>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
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                <person name="Barry K."/>
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                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
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                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
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                <person name="Slot J.C."/>
                <person name="St John F."/>
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                <person name="Sun H."/>
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                <person name="Syed K."/>
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                <person name="Wiebenga A."/>
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                <person name="Pisabarro A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K097"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH41847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="124" mass="12648" checksum="B80398D3ADEFB1BC" modified="2018-01-31" version="1">MPMGVTVISPVEVAVALPMEIAVSPLAEGTVILPMEVAVILLMEVVVIMPMEVTVILPMEVVVALPVEVAVSLPTEGTIISPVDDAGKLSCEDVSLCAALSGPLCDGPADVAVNCIVTCHKAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K0B4</accession>
    <name>A0A2H3K0B4_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">(2E,6E)-farnesyl diphosphate synthase</fullName>
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        <alternativeName>
            <fullName evidence="8">Dimethylallyltranstransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Farnesyl diphosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Farnesyltranstransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Geranylgeranyl diphosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Geranyltranstransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WOLCODRAFT_137597</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD-104</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468124">
        <property type="protein sequence ID" value="PCH41867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K0B4"/>
    <dbReference type="STRING" id="742152.A0A2H3K0B4"/>
    <dbReference type="OMA" id="FYSKAFF"/>
    <dbReference type="OrthoDB" id="6921389at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001:SF44">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PCH41867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="326" mass="36455" checksum="D03AA9BCAE8AEF70" modified="2018-01-31" version="1">MGSINALSYDPAAFNYDDLKSTLSHCSKWRQTDEKSILEPYTYLTSQSGKEVRTQMINAFNVWLGVPQEKLVVIGRIVGMLHNASLLVDDVEDDSQLRRGNPVAHKIYGIPQVINTANYVYFQAFQEISALQDSCSTDLNAIVIDELLNLHRGQGLDLLWRDTLSCPSEQEYIAMVNNKTGGLFRLSVRLMMANATRNVGVDYIPLVNLIGIYFQIRDDYCNLRSKNYAANKGYAEDLTEGKFSFPIVHGVNANPDDRSLLSILQKRPSTPTLKDHAVAYLENQTKSFAYTSQVLDKLERQVRGELARLGGNPGLEAIVNALAKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K0I5</accession>
    <name>A0A2H3K0I5_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_17395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468124">
        <property type="protein sequence ID" value="PCH41937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K0I5"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH41937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="178" mass="19984" checksum="E25647DB5A2346E6" modified="2018-01-31" version="1">MVAAESKQSPTAECIDVPVINKADLNASVTENDSDNESMGSEGSGWDLGEEKDSRDGLTQEAVLLQFSAALQNAQMIAAAREKAKKGESDRLRHYTCNFICTKQRHAEKQRLLKKQGYKPITSFFGTSKQSKKTSHNSTIQVLMMNLRGWKHQLSVLKASLYHHLHIQMVMVWKHLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K0K7</accession>
    <name>A0A2H3K0K7_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD-like protein</fullName>
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    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_73016</name>
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    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468124">
        <property type="protein sequence ID" value="PCH41957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K0K7"/>
    <dbReference type="STRING" id="742152.A0A2H3K0K7"/>
    <dbReference type="OMA" id="FYHYNRG"/>
    <dbReference type="OrthoDB" id="2012566at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02603">
        <property type="entry name" value="HAD_sEH-N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
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            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Barry K."/>
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                <person name="Spatafora J.W."/>
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                <person name="Benoit I."/>
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                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
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                <person name="Kuo A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH43234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="238" mass="26958" checksum="4832DD746BDF6E80" modified="2018-01-31" version="1">MSIVSEWLSDAMWELVAACWHQEWSERPAAPEVVAILRTEDCRRYAHPSIGVAFSTDPQTFKSYKHRVAHIDTSMPLLSRRSHGSSARRVIQKFRYGIVSLPDEVARAHRLAAWKAPAGTAPIRRRGEFAIRRPSSTRVHAARDKDIAGFEAARWSSEMVAAPREEAPETVIVGRGPLERCRVLRWRVTPRGRMDELRGPRPEPFALDRGRDRAVIVLSRGREARRLSAREEEAGALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K2V7</accession>
    <name>A0A2H3K2V7_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase RNase H-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_74194</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468135">
        <property type="protein sequence ID" value="PCH42737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K2V7"/>
    <dbReference type="STRING" id="742152.A0A2H3K2V7"/>
    <dbReference type="OMA" id="KECHHRI"/>
    <dbReference type="OrthoDB" id="3037028at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH42737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="101" mass="11556" checksum="9422281038C628AF" modified="2018-01-31" version="1">MKECHHRIWGIRFKLEVNAKYLKQMIREPDLLNAPMTRWVTYCQLFDFELCHVPADKHAVVDGLSRRPSTEDDSDESDGEEQLERLIGSVIVGCTPQAGSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K5V1</accession>
    <name>A0A2H3K5V1_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Homoserine acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WOLCODRAFT_104214</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. MetX family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468146">
        <property type="protein sequence ID" value="PCH43807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K5V1"/>
    <dbReference type="STRING" id="742152.A0A2H3K5V1"/>
    <dbReference type="OMA" id="HHAIRAF"/>
    <dbReference type="OrthoDB" id="9972683at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008220">
        <property type="entry name" value="HAT_MetX-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268:SF15">
        <property type="entry name" value="HOMOSERINE ACETYLTRANSFERASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G15350)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268">
        <property type="entry name" value="HOMOSERINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000443">
        <property type="entry name" value="Homoser_Ac_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="63"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="286"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000443-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PCH43807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="338" mass="38071" checksum="23A8B0768D0C0CDC" modified="2018-01-31" version="1">MAQESVDVPPLQYYRHGRFKVAGGVLPGAVTAYQTYGDPNNPCIVFPTCYGAKLAQGIHLIGENRALDPRKYFIVTFALFCNGESSSPSNTPPPYNGVYFPLTNYEDNIRAQYAVLTKQLGVKRVFCALGFSMGGQQAYHWAVVYPDFVDRIVVICSAARTSPHSKWLVGPKNALRSAKDYNDGHYTMQPHHAIRAFNRVCVGWAYGQTWWRQKLYLYDGLYPSLETFIREVWETPSLLHWDANDMLSLLQTWQDGDASQVRDGGDLEQCLRAIKAKVLLLPCKTDLYFCPEDSQNEVKYLQYGQLFVIDSVWGHIAGGAANPADVEFVTARILEFLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3K5X5</accession>
    <name>A0A2H3K5X5_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WOLCODRAFT_76753</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB468157">
        <property type="protein sequence ID" value="PCH44464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3K5X5"/>
    <dbReference type="STRING" id="742152.A0A2H3K5X5"/>
    <dbReference type="OMA" id="MTWIACA"/>
    <dbReference type="OrthoDB" id="5376138at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000082">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF134">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
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    </evidence>
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        <source>
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                <person name="Ohm R.A."/>
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                <person name="Syed K."/>
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                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
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            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH34212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3IW46"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH34212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="101" mass="10813" checksum="BEFE7ACE87DBA4FE" modified="2018-01-31" version="1">MRKKSNNPVVRAPAIAFGRSLRRRAALLRRAALKPRPVTVLAVACLSSLFSVRGRPPGGTPDGLVDCEGARLQPQEQHLSDTRGNVGCGDDDLRVDVLIAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IWC8</accession>
    <name>A0A2H3IWC8_WOLCO</name>
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        <recommendedName>
            <fullName evidence="10">Mannosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WOLCODRAFT_22416</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD-104</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyltransferase 22 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH34041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="497541at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005599">
        <property type="entry name" value="GPI_mannosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760:SF2">
        <property type="entry name" value="ALPHA-1,2-MANNOSYLTRANSFERASE ALG9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03901">
        <property type="entry name" value="Glyco_transf_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="4 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
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    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
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            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
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            <end position="347"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
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            <end position="416"/>
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    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
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        </location>
    </feature>
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        </location>
    </feature>
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            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH34041.1"/>
        </source>
    </evidence>
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        </source>
    </evidence>
    <sequence length="683" mass="78589" checksum="40D87C7F0E778216" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3IX60</accession>
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        <submittedName>
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        </submittedName>
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        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
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                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
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                <person name="Stenlid J."/>
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                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD-104</strain>
        </source>
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        <property type="project" value="TreeGrafter"/>
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    </feature>
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        <location>
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    </feature>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
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    <protein>
        <submittedName>
            <fullName evidence="10">OPT oligopeptide transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WOLCODRAFT_135061</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH33323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J0L3"/>
    <dbReference type="OMA" id="DAIHWPI"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00727">
        <property type="entry name" value="ISP4_OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="153"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="296"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="338"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="371"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="443"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="495"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="522"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="549"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="606"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="676"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="751"/>
            <end position="776"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PCH33323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="814" mass="92447" checksum="9E13523C9AE91DDB" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J0L6</accession>
    <name>A0A2H3J0L6_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_79680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467843">
        <property type="protein sequence ID" value="PCH35245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J0L6"/>
    <dbReference type="OMA" id="FYCYRYA"/>
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    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH35245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="108" mass="12652" checksum="012916AA5A0BD9E6" modified="2018-01-31" version="1" fragment="single">ALCFYDYFLTLDREIHFIWKTKISFSIVLFYCYRYAALSNLIFELLERDIWRRSILLNFCNVVFAALRVYAVSDRKRWLAIAVLLTGLTNPTISAVSIESSKHVSMCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J0S6</accession>
    <name>A0A2H3J0S6_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_28164</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467865">
        <property type="protein sequence ID" value="PCH35842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J0S6"/>
    <dbReference type="OMA" id="KAINECT"/>
    <dbReference type="OrthoDB" id="3010434at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58100">
        <property type="entry name" value="Bacterial hemolysins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="259"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="330"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH35842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="428" mass="45924" checksum="ED1D1A719C2995E7" modified="2018-01-31" version="1">MSAVSDDQSMATAVQTQTLTNQWNAVSNDANAYIKALTDTTFLVKDFAALRSQFETFKKVPVTKHELAVYKLAVAAGIIGNVGVEKAISQYVAANDQISAAANVSDEDAKIVKGVLGPPTDAKEQLDDLADRTGKIIDQFNTLLQQPYLDQFACTDPLDGSQTNIFTMVTGFKQEYVALQQKTLPVARDLQAYAELQIALLPIVVTKDPKPGNLTLEDFIATNKPLVDDYLVKASELSAESTAIQKKWDNAIAVVQKAINECTSNIEKWQASVDQLSEELKKVKLYAALAAAGAFIAFTAAVFLPGIGMLAALGVGGVLGALSIKEAIDASKLIQAINELKSAIKNEEATRAKLESLLPYMTNIAKSLSQVSQIWSDIATALTTLNNFYAVLGGPTGSIILDTLRPTIIESWKTVSASVKAYIDAVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J1W5</accession>
    <name>A0A2H3J1W5_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_28066</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467854">
        <property type="protein sequence ID" value="PCH35685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J1W5"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH35685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="96" mass="10565" checksum="6A9EB385AA52D518" modified="2018-01-31" version="1" fragment="single">FVPSCDVGNPLRSAIKHTLFSLQANLRHTHRDTATSVRGSLILAARVSLDAERAVCLTNKLDASPKLWHRCASFESGMLVPLTLLCTFLAPLEQHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J2B8</accession>
    <name>A0A2H3J2B8_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_145980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467865">
        <property type="protein sequence ID" value="PCH35845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J2B8"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH35845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="509" mass="58082" checksum="3A1CB81FC03981F9" modified="2018-01-31" version="1">MAAPPRPPFRQYTDCQTVIDQLDSYVSFPQPSRVHGDTSTKHAAFIENHLKNDITSVERGTFADDMLVQFCQIVSQNPNDFPPSLELQTSLTRWKGISPSSSEEELRAAFWADYLRPLADYLGLLFQHHNIDIDFKLGPSTIAGNKPDVLHVFFTQDHHNPYDEIAVASGEYKRRAVLLHHMEGMEELVDKRWVYEPDPAHLLWLQVFTQIHVRHLNWGWLTDGVLVWFAHIDPNHPMTLQVSRRYDASASSIFTLFLAFHYMVLSMQDFHLIRPELKPPCRGKLISILEIRDAGLFQLLSNMIWEALCATHPRFRIRLSVGDVVLPGLLDLVPVASAWVPVRPNVEIVVKHIADGGYASAWRGMWMGKSVVFKIAHLTTINELQREWVLVQELQRRKLDLPIPHYYGIWSLNTDASQQTSVLIMDDVGEAIRSDIHDLPSPLDKAYSIAYSKMVNARVIPQDLHSGNVVVDREGHVWGVMQHSSPLSSPLRVSFCLPKVKFHYATFPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J2L4</accession>
    <name>A0A2H3J2L4_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_157204</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467876">
        <property type="protein sequence ID" value="PCH36490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J2L4"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH36490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="186" mass="18997" checksum="0E11732491C1871F" modified="2018-01-31" version="1">MCSQISSGSAGTVRACGGGDGGGGGAGSMAADGQIGRIAARMARISAARVQHFGVAGLQAMRAAWEEQAGHSPAGGSSQQATTRVPCHSPIILCYSTRGRNAAPRLLIVADVEQPGRGGQSGSSPSDRSGDADAIWLSAAPASRSPRLSCLITHHHAQLPSQPHAPHSAEKADVIRRPVTVLLRQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J329</accession>
    <name>A0A2H3J329_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromatin associated protein KTI12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">WOLCODRAFT_140230</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the KTI12 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467865">
        <property type="protein sequence ID" value="PCH36115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J329"/>
    <dbReference type="STRING" id="742152.A0A2H3J329"/>
    <dbReference type="OMA" id="THSRWDK"/>
    <dbReference type="OrthoDB" id="9972657at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013641">
        <property type="entry name" value="KTI12/PSTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12435">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08433">
        <property type="entry name" value="KTI12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PCH36115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="299" mass="33075" checksum="AE918BC83E3BFF87" modified="2018-01-31" version="1">MALITVSGYPSSGKSRRAEQLKTHLEARLRDPGYAGPNLKVSVVSDDVLNIDRQVYNDGRAEKPARAALFTAAQRQMGQDTILIIDAMNYIKGFRYQLYCAAREQKLRVCTMYVAATPEICKEWNASRQDGRAYAPETLDNLLLRYEEPSSMVRWDSPLFTVPWTDDDVPADEIWKAVTEGIVKPPNAGTQAVPKAPTDALRTLEHTTTTMVSAIMAEQTASQGTGGPVTLSLSATLRQRLTLPARNITLSELQRLKRLFVTVHKKAITLGTTEKGAVDWSETSIADKFASYIEGNLKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J3Q3</accession>
    <name>A0A2H3J3Q3_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_20468</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467876">
        <property type="protein sequence ID" value="PCH36315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J3Q3"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH36315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="140" mass="15456" checksum="ACF04815A420A3B4" modified="2018-01-31" version="1">MSTPLIKILLVDGTTYLIAFLLTYVLVIVFTSGLLNTFPNLMLSRFMFNLRHASADQMTDNKLDQQDSNAVGFTSGTSSTLETILRLDFGTIGNMGAPLSHGSSEYWNVNEGLEEMTCNEELIENAYAQDIGVQHIQEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J466</accession>
    <name>A0A2H3J466_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Acireductone dioxygenase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Acireductone dioxygenase (Fe(2+)-requiring)</fullName>
            <shortName evidence="11">ARD'</shortName>
            <shortName evidence="11">Fe-ARD</shortName>
            <ecNumber evidence="11">1.13.11.54</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Acireductone dioxygenase (Ni(2+)-requiring)</fullName>
            <shortName evidence="11">ARD</shortName>
            <shortName evidence="11">Ni-ARD</shortName>
            <ecNumber evidence="11">1.13.11.53</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ADI1</name>
        <name evidence="12" type="ORF">WOLCODRAFT_124658</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 3-(methylsulfanyl)propanoate + CO + formate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:14161"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:17245"/>
            <dbReference type="ChEBI" id="CHEBI:49016"/>
            <dbReference type="ChEBI" id="CHEBI:49252"/>
            <dbReference type="EC" id="1.13.11.53"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 4-methylsulfanyl-2-oxobutanoate + formate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:24504"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:16723"/>
            <dbReference type="ChEBI" id="CHEBI:49252"/>
            <dbReference type="EC" id="1.13.11.54"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </cofactor>
        <text evidence="11">Binds either 1 Fe or Ni cation per monomer. Iron-binding promotes an acireductone dioxygenase reaction producing 2-keto-4-methylthiobutyrate, while nickel-binding promotes an acireductone dioxygenase reaction producing 3-(methylsulfanyl)propanoate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="11">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 5/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the acireductone dioxygenase (ARD) family.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.54" evidence="11"/>
    <dbReference type="EC" id="1.13.11.53" evidence="11"/>
    <dbReference type="EMBL" id="KB467832">
        <property type="protein sequence ID" value="PCH34573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J466"/>
    <dbReference type="STRING" id="742152.A0A2H3J466"/>
    <dbReference type="OMA" id="WYMDESQ"/>
    <dbReference type="OrthoDB" id="1867259at2759"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00878"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010308">
        <property type="term" value="F:acireductone dioxygenase (Ni2+-requiring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010309">
        <property type="term" value="F:acireductone dioxygenase [iron(II)-requiring] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02232">
        <property type="entry name" value="cupin_ARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000099">
        <property type="entry name" value="1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03154">
        <property type="entry name" value="Salvage_MtnD_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004313">
        <property type="entry name" value="ARD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027496">
        <property type="entry name" value="ARD_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23418">
        <property type="entry name" value="ACIREDUCTONE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23418:SF0">
        <property type="entry name" value="ACIREDUCTONE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03079">
        <property type="entry name" value="ARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11 12" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="8 11" id="KW-0408">Iron</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 11" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="3 11" id="KW-0533">Nickel</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="11">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PCH34573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="187" mass="21743" checksum="34F3ABA9698F072A" modified="2018-01-31" version="1">MRAYYMDDDLVGDQRLPHDSGRSVSDETLDKLGVLRWHIPVDPAGEWQSQVETIADERSYRNRDICLVTKEGMGDEFEKNLKRFYHEHMHEDEEIRFIIEGSGFFDVREHSTDAWVRLHLSAGDMIVLPAGIYHRFSLDMGNKSRTMRLFKDEPKWIAYNRSSATDTNPFRLDYLKSLQGQDVSVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J5I3</accession>
    <name>A0A2H3J5I3_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PLC-like phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_22397</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH34019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J5I3"/>
    <dbReference type="STRING" id="742152.A0A2H3J5I3"/>
    <dbReference type="OMA" id="TFDCNVN"/>
    <dbReference type="OrthoDB" id="7984201at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051057">
        <property type="entry name" value="PI-PLC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593:SF140">
        <property type="entry name" value="PLC-LIKE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26146">
        <property type="entry name" value="PI-PLC_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013816807" evidence="1">
        <location>
            <begin position="25"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH34019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="360" mass="38529" checksum="80CF19BDD1FF0451" modified="2018-01-31" version="1">MFASAKSITQVVLSLALLPLAAHAASIKRAATTCNGHSELCDRSYGNITFVGAHDSYAVSSTSLAANQDYNVTQQLKDGIRMLQMQTHNQSGTIQLCHTSCDLFNGGTLENYLQSVKSWMDNNTDDVVSLLIVNSYDNFPPSAYDTVFKSVGLDTLAYSPPSANLTESEWPTLGSMINNGTRLVVFLTTQADYEAIPYLIDEFTNIWETAYDVTTTTFNCDVNRTNGNPNEQMYLINHFLDSSIAGILYPDKSAASQTNGVNGTGSLGQQVATCASEYDRNPNFMLVDFYEYGNGSVFEVAATANGVTYSPTSPIATPITGSGGSSSSSGAWGGYQITGAHFAAMMAMSMGMLLGALTVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J5Y7</accession>
    <name>A0A2H3J5Y7_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WOLCODRAFT_95587</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH37662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J5Y7"/>
    <dbReference type="STRING" id="742152.A0A2H3J5Y7"/>
    <dbReference type="OMA" id="WIRRENE"/>
    <dbReference type="OrthoDB" id="422720at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030385">
        <property type="entry name" value="G_IRG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007743">
        <property type="entry name" value="Immunity-related_GTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051515">
        <property type="entry name" value="IRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32341">
        <property type="entry name" value="INTERFERON-INDUCIBLE GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32341:SF10">
        <property type="entry name" value="INTERFERON-INDUCIBLE GTPASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05049">
        <property type="entry name" value="IIGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51716">
        <property type="entry name" value="G_IRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="IRG-type G" evidence="7">
        <location>
            <begin position="218"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="51"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="101"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PCH37662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="440" mass="49988" checksum="0F5892386E8A663F" modified="2018-01-31" version="1">MGIVESVLIGVTALIGGIICLVQSLQNASSSGQIAPNPIVEENEERICKEQERAAATEAEHKRLEERQRDWRSTCSAWSSRERRRRNASSRQTWGASEGQRQAHEERARAEQQQKIAEEERKKAEGERRLADERQQAAEEERQRAEEDRARADEQARLARIAKERAEQEKAEADDRAKQAAAELEEAQRKLREGVRPVVIPTSEEFEATKKRLCYQEGIFHFAIAGISGSGKSSLINAFRGLHNSDHGAAPTGVTETTSEITRYPDPNRANPWVWYDVPGAGTLTIPDWAYFNQQGLYVFDCIIVLFDNRFTATDVAILKNCRLFNIPAYIVRSKSNQHISNILSDMGYDNGEEHRTLRRTRKKDARDKYITETRASVAHNLEEAGLPLQRVYVVSKETLLKIVKQGHARDEVLDELELLTDLLTEARRRRLRSVTVACE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J669</accession>
    <name>A0A2H3J669_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_79302</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467843">
        <property type="protein sequence ID" value="PCH35263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J669"/>
    <dbReference type="STRING" id="742152.A0A2H3J669"/>
    <dbReference type="OMA" id="HESERYI"/>
    <dbReference type="OrthoDB" id="2669721at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH35263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="429" mass="48859" checksum="2E90A94CA7EF8513" modified="2018-01-31" version="1">MHLVAINIPDLFISLWRSTIQCDPNDSRSTWRFMVLTKDTWEAHGKAVAATTPYLPGSFDRAPRNIADKLTSGYKAWEHLIHLYCLCPALLYNVLPEVFYRNLCKLVRGVRLLYQCNISHADIMEASALFIMFEKDYELIYYERKTARLHFVWQSIHSVTHIPTETERLGPEIIFSQWPMERLLGELGLQIRNHSNAYANMAEIAVRRCRTNAIHAMIPALTEPQSLPRGAIDLGGGYALLRRSEDKATPITDAEKCVIVPYLESMGVAMSAYWTSNPTISRWAHVILPNKQVVRSLWREADTPVEKLRIACNVKIYDNGVYMIAEVQYFFQAPHPHRNSGLALMSTYSDPDQDLLNYSENTLYSCKYQGARNLKVVNVTSIQAVVAMIPHPAPYGPHGRNLEGNFFLAEKLGLDLLQFTHTDEITADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J6I4</accession>
    <name>A0A2H3J6I4_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-(apurinic or apyrimidinic site) lyase</fullName>
            <ecNumber evidence="3">4.2.99.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">WOLCODRAFT_130506</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the type-1 OGG1 family.</text>
    </comment>
    <dbReference type="EC" id="4.2.99.18" evidence="3"/>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH37826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J6I4"/>
    <dbReference type="STRING" id="742152.A0A2H3J6I4"/>
    <dbReference type="OMA" id="QNLCTHF"/>
    <dbReference type="OrthoDB" id="238681at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034039">
        <property type="term" value="F:8-oxo-7,8-dihydroguanine DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1670.10:FF:000005">
        <property type="entry name" value="N-glycosylase/DNA lyase OGG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="entry name" value="Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012904">
        <property type="entry name" value="OGG_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052054">
        <property type="entry name" value="Oxidative_DNA_repair_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10242">
        <property type="entry name" value="8-OXOGUANINE DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10242:SF2">
        <property type="entry name" value="N-GLYCOSYLASE_DNA LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07934">
        <property type="entry name" value="OGG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55945">
        <property type="entry name" value="TATA-box binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 15" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013675622" description="DNA-(apurinic or apyrimidinic site) lyase" evidence="13">
        <location>
            <begin position="22"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="HhH-GPD" evidence="14">
        <location>
            <begin position="151"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="374"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PCH37826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="458" mass="50701" checksum="E012CB973915B582" modified="2018-01-31" version="1">MITPPAGFRALPLSITQLSLAAVLQCGQSFRWNIFPLLSLASGTSGADNLHPTHEYRLCLRDRVVCLRQSLDTLFYRSVLPGPPLSRTLQDEREAETLAWLRDYFQLDVDLEALYEQWGKRDSVFMNRQQRFSGIRVLRQDPFENLISFICSSNNNIARITKMVKALCRQYSPALIALPSPALTDDDSNDPSTQELTEAYHPFPPPSALAAPEVASTLRGLGFGYRAEFIQRTAQMLVEAHGVAASESGVEPAEKWLHSLRKMSTSDAREELLKFVGVGRKVADCVLLMSLDKREVIPVDTHVHQIAMKHYGVSGSSKAKSNMTPKLYDEVSSKLAAVWGDYAGWAHLVLFTSDLKSFSSYGLSTTAAFPKAQPDVKITSRQRKSVLATPSATPSPAGKRKRKQVQEATVAIIANEKVESSSTQHSDVELPALDDSSMADRVKRRRRVKVTIAAVALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J6J5</accession>
    <name>A0A2H3J6J5_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WOLCODRAFT_135870</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the exportin family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH38316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3J7W6"/>
    <dbReference type="STRING" id="742152.A0A2H3J7W6"/>
    <dbReference type="OMA" id="WAFKHNN"/>
    <dbReference type="OrthoDB" id="27218at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000022">
        <property type="entry name" value="protein EXPORTIN 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041123">
        <property type="entry name" value="CRM1_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041235">
        <property type="entry name" value="Exp1_repeat_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045065">
        <property type="entry name" value="XPO1/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014877">
        <property type="entry name" value="XPO1_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040485">
        <property type="entry name" value="XPO1_repeat_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223">
        <property type="entry name" value="EXPORTIN 1/5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223:SF2">
        <property type="entry name" value="EXPORTIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08767">
        <property type="entry name" value="CRM1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18777">
        <property type="entry name" value="CRM1_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18784">
        <property type="entry name" value="CRM1_repeat_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18787">
        <property type="entry name" value="CRM1_repeat_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01102">
        <property type="entry name" value="CRM1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="7">
        <location>
            <begin position="34"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1042"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1042"/>
            <end position="1055"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PCH38316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="1074" mass="121958" checksum="4F21F95B3E946591" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J7Y4</accession>
    <name>A0A2H3J7Y4_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Kinetochore protein Spc24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WOLCODRAFT_130860</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the NDC80 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Chromosome</location>
            <location evidence="10">Centromere</location>
            <location evidence="10">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the SPC24 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH38382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="742152.A0A2H3J7Y4"/>
    <dbReference type="OMA" id="AQCTSHF"/>
    <dbReference type="OrthoDB" id="3344830at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031262">
        <property type="term" value="C:Ndc80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11565">
        <property type="entry name" value="RWD_Spc24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013252">
        <property type="entry name" value="Ndc80_Spc24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038066">
        <property type="entry name" value="Spc24_Fungi_globular_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22142">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22142:SF2">
        <property type="entry name" value="KINETOCHORE PROTEIN SPC24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08286">
        <property type="entry name" value="Spc24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143026">
        <property type="entry name" value="Kinetochore globular domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="9 10" id="KW-0137">Centromere</keyword>
    <keyword evidence="2 10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 10" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="4 10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="90"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PCH38382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="193" mass="21350" checksum="513DCF0C6E859FB6" modified="2018-01-31" version="1">MSISIKDTVKALRDMRPLINPDGDFMTITAAEERMAITEAERRKELEGLQSKLRTMTRNLEAARVSSTRPSTIPSAEAHAAMINELDGQRLQLVKAINDAESALASKEAELARLKEELRALEEYDSAAEHDLDSTALRLAIYKGLGFEPIMGDDGRIAKMLVRSSSGDVHCVVFDSSTSDYEYTDLLWKLASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3J8R1</accession>
    <name>A0A2H3J8R1_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_156907</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Phaeolaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">MD-104</strain>
        </source>
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            <end position="87"/>
        </location>
    </feature>
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        <location>
            <begin position="111"/>
            <end position="174"/>
        </location>
    </feature>
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        <location>
            <begin position="199"/>
            <end position="225"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
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        <location>
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            <end position="52"/>
        </location>
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    </feature>
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            <end position="131"/>
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        <location>
            <begin position="138"/>
            <end position="153"/>
        </location>
    </feature>
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            <begin position="203"/>
            <end position="216"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
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        </source>
    </evidence>
    <sequence length="318" mass="34631" checksum="98E87F65E39039BA" modified="2018-01-31" version="1">MRSGTPVNQSEYPVPESEDPDEYNPPPLEDSSDSEDEYDADDDEDMDDEHDEHDEHDHGTDTPRSPCSPTPIPRSFFDHRYVPDSSRRAPGVNLWRLYRFQPIPASQMQGHAVTTSATASHCTSVDTTSPASPEAAGSATSDSHPPSSTTTTPLDMPAEGAEPSEPQVLSPAATDPNVNVVVPVIVVGLQSVDIGHTHNHAHGAADHMQPSDDVRSTESSLGSAENWRNQSSIAPMDIPSHGHPWRSRAADALRPLLPGRRSGSHNRQSTDANGARTFLICVIGGYYPPNHHMVMGSDSLDLYEALWELAELLRCRRI</sequence>
</entry>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
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                <person name="Benoit I."/>
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                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
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                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
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                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
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                <person name="Eastwood D.C."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
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        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="83" mass="9091" checksum="7A58805DD4E73265" modified="2018-01-31" version="1" fragment="single">MHILALTEGPYLALAAAVYTKKVIVEDLASISLHVHYTNSVQTQAGEHVTAALRVALPALRGQYLHFFPSRVPADFPSRDFST</sequence>
</entry>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
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                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
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                <person name="Wiebenga A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">MD-104</strain>
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    </dbReference>
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            <begin position="19"/>
            <end position="342"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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    <sequence length="349" mass="38056" checksum="0390A361BAAACC6F" modified="2018-01-31" version="1">MSIPQTQQAWRATAKGAPGKVLRLDNDVPVPVKLKKGEVLVKVQAAALNPIGYKLMQLLPGFVLKRPYIPEHDFAGVVVDSNGTEYQNGDAVYGFLTVPLFMQTRQGTLAQYIRAPTTHFIRRPDDIPPTQAAGVPLAAMTAYQGLFQVAHLEPEQRVFINGGSTAVGSFAIQLAKAIGCKVTATASGKNEEYVRSLGADEFVDYTKGPLHTALAENSPSPKYHVIFETVGLVDTALYTNSEAYLAPGGVFVSTGPQPKGFDIAGIGKLLWKVFLQPKWLGGTKRTWKMVSVAEKREDLQKITQYITEGKVRPLVDSVYGFEDVPKAYERIMTSRATGKVVIKVDSEAE</sequence>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
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            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD-104</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH33157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JB32"/>
    <dbReference type="STRING" id="742152.A0A2H3JB32"/>
    <dbReference type="OMA" id="CTALQWM"/>
    <dbReference type="OrthoDB" id="79562at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09599">
        <property type="entry name" value="M1_LTA4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000003">
        <property type="entry name" value="Leukotriene A(4) hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1730:FF:000004">
        <property type="entry name" value="Leukotriene A(4) hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2010.30:FF:000001">
        <property type="entry name" value="Leukotriene A(4) hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.320">
        <property type="entry name" value="Peptidase M1, leukotriene A4 hydrolase/aminopeptidase C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049980">
        <property type="entry name" value="LTA4H_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038502">
        <property type="entry name" value="M1_LTA-4_hydro/amino_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034015">
        <property type="entry name" value="M1_LTA4H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015211">
        <property type="entry name" value="Peptidase_M1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45726">
        <property type="entry name" value="LEUKOTRIENE A-4 HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45726:SF3">
        <property type="entry name" value="LEUKOTRIENE A-4 HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09127">
        <property type="entry name" value="Leuk-A4-hydro_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01263">
        <property type="entry name" value="Leuk-A4-hydro_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M1 leukotriene A4 hydrolase/aminopeptidase C-terminal" evidence="12">
        <location>
            <begin position="482"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="308"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="396"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="134"/>
            <end position="136"/>
        </location>
        <ligand>
            <name>a peptide</name>
            <dbReference type="ChEBI" id="CHEBI:60466"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="278"/>
            <end position="283"/>
        </location>
        <ligand>
            <name>a peptide</name>
            <dbReference type="ChEBI" id="CHEBI:60466"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="595"/>
            <end position="597"/>
        </location>
        <ligand>
            <name>a peptide</name>
            <dbReference type="ChEBI" id="CHEBI:60466"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR634015-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR634015-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR634015-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PCH33157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="640" mass="71020" checksum="4CE9A909CA19348C" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JBE9</accession>
    <name>A0A2H3JBE9_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mitotic spindle checkpoint HORMA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">WOLCODRAFT_160509</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MAD2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH33994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JBE9"/>
    <dbReference type="STRING" id="742152.A0A2H3JBE9"/>
    <dbReference type="OMA" id="CEDFPWI"/>
    <dbReference type="OrthoDB" id="21254at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016035">
        <property type="term" value="C:zeta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.10">
        <property type="entry name" value="HORMA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003511">
        <property type="entry name" value="HORMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036570">
        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045091">
        <property type="entry name" value="Mad2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11842">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11842:SF10">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02301">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56019">
        <property type="entry name" value="The spindle assembly checkpoint protein mad2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50815">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HORMA" evidence="2">
        <location>
            <begin position="18"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH33994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="242" mass="26524" checksum="36E29592BD8E2714" modified="2018-01-31" version="1">MYFLGNASTRRVQLDAWSQTVQGIAEFIEVAIHTILYVRQIYPVDLFVRRKKYNTPVFQSRHPALNEYISGAVGALAEELATGSVDKIAVVVKNQDDVALERFIFAVQNMINVDPYNKDISVEGAIAPSSLGQYLRSFLVKLNMIEAQLGQLDSCGELSFAIVLELHDNKAPATSYGEDRDPPPWVPALTPHTTAGAADTAELHMVRAVDTGIINLSLAVQESAEKLKLGREDPKGKGRVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JBI3</accession>
    <name>A0A2H3JBI3_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_20966</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467909">
        <property type="protein sequence ID" value="PCH37173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JBI3"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH37173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="165" mass="17568" checksum="261487800D663651" modified="2018-01-31" version="1">MDNKLFGGINDAALISMAMDDTVASTPIATAASAPITTDTSTSAATATSAPITTTAADGNILPTNRIFDDKPTVRFRLPFAFVSRRLNGTQVLPGNLNDHCGIFGGIGLTNPNWLNNTATCKILIEGSKVGINATMVMVKKVYTFMYGTDIHYSNYICSELINIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JBR5</accession>
    <name>A0A2H3JBR5_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Helicase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WOLCODRAFT_85980</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468020">
        <property type="protein sequence ID" value="PCH39636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JBR5"/>
    <dbReference type="STRING" id="742152.A0A2H3JBR5"/>
    <dbReference type="OMA" id="TTHEDAW"/>
    <dbReference type="OrthoDB" id="2803695at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF26">
        <property type="entry name" value="FAMILY HELICASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G09120)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="5">
        <location>
            <begin position="10"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PCH39636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="132" mass="14776" checksum="D082B33FF62E7025" modified="2018-01-31" version="1" fragment="single">MAERGPNTAPDKIIVFTAFPSNISVLSEFLEGSGIKFMTLTGIDLLKDHAKMLKAFWDTTHEDAWVLIISGAGMMGLNIAFVNILDTLWSAQEDVQLIGRVWRHPQTKLVEVYRLIVAGTPNVFLNNISFER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JCE5</accession>
    <name>A0A2H3JCE5_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WOLCODRAFT_134791</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468009">
        <property type="protein sequence ID" value="PCH39561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="742152.A0A2H3JCE5"/>
    <dbReference type="OMA" id="PVCQVPI"/>
    <dbReference type="OrthoDB" id="2423195at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031380">
        <property type="term" value="C:nuclear RNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031048">
        <property type="term" value="P:regulatory ncRNA-mediated heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF341">
        <property type="entry name" value="NFX1-TYPE ZINC FINGER-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="4">
        <location>
            <begin position="15"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="15"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1912"/>
            <end position="1984"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PCH39561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="2081" mass="234230" checksum="D017BF84EF47F04C" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JCN5</accession>
    <name>A0A2H3JCN5_WOLCO</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_141769</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH33717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JCN5"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="196"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH33717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="225" mass="24314" checksum="1C8B5ABCD03102F1" modified="2018-01-31" version="1" fragment="single">MLGLLQMKASVMSPERKRRNVLLSRKWSNLQQRSPTPSCDWRSELTSGQSIPQEIFDLPSPSGSSMNTSLEASSTGIDQAAPMAVLPAVDSALSLPSAGSGASVLRSLLSVPLDPVTQPVLHTIRASVSPEVHRYRTRENLRTPTKVSVQPIKPRQQSPIIRDSLSVTSKAGGTEAMQDRSDCPASKVQAVKSFSSFSSRDSSLRSLASGSATNRRPELRITHTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JCS5</accession>
    <name>A0A2H3JCS5_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WOLCODRAFT_21580</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDXG' lipolytic enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468042">
        <property type="protein sequence ID" value="PCH39691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JCS5"/>
    <dbReference type="STRING" id="742152.A0A2H3JCS5"/>
    <dbReference type="OMA" id="HYWEANA"/>
    <dbReference type="OrthoDB" id="2152029at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033140">
        <property type="entry name" value="Lipase_GDXG_put_SER_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF26">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01174">
        <property type="entry name" value="LIPASE_GDXG_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="4">
        <location>
            <begin position="130"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PCH39691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="331" mass="36531" checksum="F749BEC2CA981AAC" modified="2018-01-31" version="1">MAWQSILCRVSSPCLFGRSFLHRYSRCPNGPDPAKVAASAEAEKVGFVWVPPLSTEYIVGEVRDIAQLNGVEAKKTFGYWTKDGWRLHYGLSQPPRRFDRTNLWWPTFPLSACLAHLLLRLSSSPFPNANPFPAALFDALAGYHYLIHTIGVSARNIVVSGDSAGGHLAISLVRYLATNQIPGLPVPGALLLLSPTTEWVVTHDGPDSSFRKNASTDYCADLFRGYTKRSLLGKLPPEAAYTNAWISPASLELSDVSGMFKGFPKTYIAAGDAEILFDAMRTFGKRLAEDIGEDMVTFDAVRDGTHDCLALELHEPQRTDTLKRIASWLEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JCS6</accession>
    <name>A0A2H3JCS6_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_135298</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467831">
        <property type="protein sequence ID" value="PCH33757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JCS6"/>
    <dbReference type="STRING" id="742152.A0A2H3JCS6"/>
    <dbReference type="OMA" id="EYVRSNQ"/>
    <dbReference type="OrthoDB" id="2367685at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH33757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="199" mass="20232" checksum="00F20A677775249C" modified="2018-01-31" version="1">MSQNSNDPPPPYTPRRHSFSGSTRPNLTVPNASARTATSQPRTPPPDATSSRGLFGHHRHHGGGFMGRLQNRLQPQQQRPYSTPGYQPAFRPPMGDPYSYNRPGSGRFGGLGGLGGFGGFGGNSYGNSYGNSYGGNRHGFGGAGLPLLGGLAGGLILGEALDDFGGGFGGPFGGGFGGPFDGGFGGGGFDNGFGGGGFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
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    <name>A0A2H3JE94_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_16575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
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                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
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                <person name="Yadav J.S."/>
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                <person name="Boyd A."/>
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    </evidence>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
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                <person name="Patyshakuliyeva A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
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                <person name="Benoit I."/>
                <person name="Boyd A."/>
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                <person name="Coutinho P.M."/>
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                <person name="Heitman J."/>
                <person name="Hesse C."/>
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                <person name="Kallen N."/>
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                <person name="Kuo A."/>
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                <person name="Lindquist E."/>
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                <person name="Martin R."/>
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                <person name="Morgenstern I."/>
                <person name="Morin E."/>
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                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
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                <person name="Sabat G."/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
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                <person name="Coutinho P.M."/>
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                <person name="Ferreira P."/>
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                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="PCH40295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JFG5"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH40295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="155" mass="16859" checksum="F3C639F9A309119A" modified="2018-01-31" version="1">MARSADCVAGSSTRACACRGPSSDRRGRDGGPCGGDAHVPEGMERFARCLPLGRDWGTWRDEVHAALVHTGEGRVVCARVSWWAEYECTEVKSEWMRSIGASGRSGCENRVGKRHGRVWTRAERGCSLNEAMTASCALLGVITTYSASRQDRKPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JFU2</accession>
    <name>A0A2H3JFU2_WOLCO</name>
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        <recommendedName>
            <fullName evidence="4">tripeptidyl-peptidase II</fullName>
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        </recommendedName>
    </protein>
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        <name evidence="17" type="ORF">WOLCODRAFT_88994</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Secreted tripeptidyl-peptidase which degrades proteins at acidic pHs and is involved in virulence.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal tripeptide from a polypeptide.</text>
            <dbReference type="EC" id="3.4.14.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="15">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
            <location evidence="3">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.4.14.10" evidence="4"/>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH41060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JFU2"/>
    <dbReference type="STRING" id="742152.A0A2H3JFU2"/>
    <dbReference type="OMA" id="GETVWNE"/>
    <dbReference type="OrthoDB" id="409122at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008240">
        <property type="term" value="F:tripeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04056">
        <property type="entry name" value="Peptidases_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11377">
        <property type="entry name" value="Pro-peptidase_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000015">
        <property type="entry name" value="Tripeptidyl peptidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015366">
        <property type="entry name" value="S53_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030400">
        <property type="entry name" value="Sedolisin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050819">
        <property type="entry name" value="Tripeptidyl-peptidase_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218">
        <property type="entry name" value="PROTEASE S8 TRIPEPTIDYL PEPTIDASE I CLN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218:SF15">
        <property type="entry name" value="TRIPEPTIDYL-PEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09286">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00944">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51695">
        <property type="entry name" value="SEDOLISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11 15" id="KW-0106">Calcium</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15 17" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="10 15" id="KW-0720">Serine protease</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0843">Virulence</keyword>
    <keyword evidence="13" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Peptidase S53" evidence="16">
        <location>
            <begin position="195"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="15">
        <location>
            <position position="271"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="15">
        <location>
            <position position="275"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="15">
        <location>
            <position position="469"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="511"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="512"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="530"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="532"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PCH41060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="551" mass="56963" checksum="E751088E8B03C892" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JFW4</accession>
    <name>A0A2H3JFW4_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Histidine biosynthesis trifunctional protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="19">Phosphoribosyl-AMP cyclohydrolase</fullName>
                <ecNumber evidence="19">3.5.4.19</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="19">Phosphoribosyl-ATP pyrophosphohydrolase</fullName>
                <ecNumber evidence="19">3.6.1.31</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="19">Histidinol dehydrogenase</fullName>
                <shortName evidence="19">HDH</shortName>
                <ecNumber evidence="19">1.1.1.23</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="22" type="ORF">WOLCODRAFT_143382</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 19">
            <text>1-(5-phospho-beta-D-ribosyl)-5'-AMP + H2O = 1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:20049"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58435"/>
            <dbReference type="ChEBI" id="CHEBI:59457"/>
            <dbReference type="EC" id="3.5.4.19"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 19">
            <text>1-(5-phospho-beta-D-ribosyl)-ATP + H2O = 1-(5-phospho-beta-D-ribosyl)-5'-AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22828"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:59457"/>
            <dbReference type="ChEBI" id="CHEBI:73183"/>
            <dbReference type="EC" id="3.6.1.31"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18 19">
            <text>L-histidinol + 2 NAD(+) + H2O = L-histidine + 2 NADH + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:20641"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:57699"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/9.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 3/9.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7 19">In the C-terminal section; belongs to the histidinol dehydrogenase family.</text>
    </comment>
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    <dbReference type="EC" id="3.6.1.31" evidence="19"/>
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        <property type="protein sequence ID" value="PCH41080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="742152.A0A2H3JFW4"/>
    <dbReference type="OMA" id="SVFIGAW"/>
    <dbReference type="OrthoDB" id="1703565at2759"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00007"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="F:histidinol dehydrogenase activity"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:NAD binding"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="F:phosphoribosyl-AMP cyclohydrolase activity"/>
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        <property type="term" value="F:phosphoribosyl-ATP diphosphatase activity"/>
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    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
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        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="NTP-PPase_His4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Histidine biosynthesis bifunctional protein HisIE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Histidine biosynthesis trifunctional protein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Histidinol dehydrogenase"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Histidinol dehydrogenase, chloroplastic"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1080">
        <property type="entry name" value="MazG-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nitrogenase molybdenum iron protein domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.810">
        <property type="entry name" value="Phosphoribosyl-AMP cyclohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01024">
        <property type="entry name" value="HisD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
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        <property type="entry name" value="HisE"/>
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    <dbReference type="InterPro" id="IPR016298">
        <property type="entry name" value="Histidine_synth_trifunct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001692">
        <property type="entry name" value="Histidinol_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012131">
        <property type="entry name" value="Hstdl_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021130">
        <property type="entry name" value="PRib-ATP_PPHydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002496">
        <property type="entry name" value="PRib_AMP_CycHydrolase_dom"/>
    </dbReference>
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        <property type="entry name" value="PRib_AMP_CycHydrolase_sf"/>
    </dbReference>
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        <property type="entry name" value="hisD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="histidine_hisI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21256:SF2">
        <property type="entry name" value="HISTIDINE BIOSYNTHESIS TRIFUNCTIONAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21256">
        <property type="entry name" value="HISTIDINOL DEHYDROGENASE HDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00815">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01502">
        <property type="entry name" value="PRA-CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01503">
        <property type="entry name" value="PRA-PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001257">
        <property type="entry name" value="His_trifunctional"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00083">
        <property type="entry name" value="HOLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101386">
        <property type="entry name" value="all-alpha NTP pyrophosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141734">
        <property type="entry name" value="HisI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00611">
        <property type="entry name" value="HISOL_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 19" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="13 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16 19" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="11 19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="15 19" id="KW-0520">NAD</keyword>
    <keyword evidence="10 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14 19" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Phosphoribosyl-AMP cyclohydrolase" evidence="21">
        <location>
            <begin position="214"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="381"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00005204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00008260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRNR" id="PIRNR001257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF01502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="PCH41080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="854" mass="90685" checksum="EAF793238B21214B" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JGJ6</accession>
    <name>A0A2H3JGJ6_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Bromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WOLCODRAFT_16834</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD-104</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="PCH41021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
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    <dbReference type="PANTHER" id="PTHR15398">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15398:SF4">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN 8 ISOFORM X1"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
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    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="435"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="143"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="147"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="173"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="213"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="278"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="294"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="304"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="350"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="368"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PCH41021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="531" mass="59848" checksum="69D9907FCA2BB66E" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JGP9</accession>
    <name>A0A2H3JGP9_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Neutral amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WOLCODRAFT_135943</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH37939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JGP9"/>
    <dbReference type="STRING" id="742152.A0A2H3JGP9"/>
    <dbReference type="OMA" id="HVITTIV"/>
    <dbReference type="OrthoDB" id="294730at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000039">
        <property type="entry name" value="Neutral amino acid transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF479">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="262"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="305"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="351"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="378"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="420"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="51"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PCH37939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="465" mass="49644" checksum="5436A771884E4C8A" modified="2018-01-31" version="1">MANNLRASMTGSSIDDSSAYGNGKEAAQVVQHSEFDVYGDEENADIQYRTMVWWKAAALMLAETVSLGILSIPSVFGSLGMAAGCILVIGLGAVATLTGYMIGAFKLRYPHVHNMADAGEILAGPIGREVLGASQVIFMIFICGSHVLTGLIAFDTITAGASCSVLWAGVSAIICLVLTIPRTLNGISYLSVASFISIITAVLITMIGVGVAGHKGGVTAKADLSFASGFLAVTDVIFAYAGHVGFFTFIAEMRQPEDFSKALYFLQIADTTLYLIVGVVVYAYAGDNVVSPALGNTGVTLRKVAYGIALPTIMIAGVINGHVCAKLIFVRIFRRNGQASKHMTTHSWTGWLTWTGLCFAIWAIAFVIAEVIPFFNDLLGVISALFASWFTYGISGVFWFHLTPREQRWSTPWQRVKTIFWAGIILMGAFIMVAGLYASIDSIVEGYKAGTFSGPFTCASQALTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JGS7</accession>
    <name>A0A2H3JGS7_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">[histone H3]-lysine(4) N-trimethyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.354</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WOLCODRAFT_82990</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60260"/>
            <dbReference type="Rhea" id="RHEA-COMP:15537"/>
            <dbReference type="Rhea" id="RHEA-COMP:15547"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.354"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60272"/>
            <dbReference type="Rhea" id="RHEA-COMP:15537"/>
            <dbReference type="Rhea" id="RHEA-COMP:15540"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60268"/>
            <dbReference type="Rhea" id="RHEA-COMP:15540"/>
            <dbReference type="Rhea" id="RHEA-COMP:15543"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61929"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.1.1.354" evidence="2"/>
    <dbReference type="EMBL" id="KB467898">
        <property type="protein sequence ID" value="PCH36908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JGS7"/>
    <dbReference type="STRING" id="742152.A0A2H3JGS7"/>
    <dbReference type="OMA" id="EYECRCG"/>
    <dbReference type="OrthoDB" id="308383at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140999">
        <property type="term" value="F:histone H3K4 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044570">
        <property type="entry name" value="Set1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45814">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45814:SF2">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00508">
        <property type="entry name" value="PostSET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
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        </location>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH36908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Barry K."/>
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                <person name="Martinez A.T."/>
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                <person name="Yadav J.S."/>
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                <person name="Benoit I."/>
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                <person name="Ferreira P."/>
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                <person name="Gorecki P."/>
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                <person name="Rokas A."/>
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                <person name="Salamov A."/>
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                <person name="Sun S."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
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        </location>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
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                <person name="Glotzer D."/>
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                <person name="Heitman J."/>
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                <person name="Wiebenga A."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD-104</strain>
        </source>
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            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46203:SF1">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        </location>
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    </feature>
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    </feature>
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        <source>
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    </evidence>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023128"/>
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    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PCH38469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="269" mass="30433" checksum="0E24084F7CCE2A9C" modified="2018-01-31" version="1">MSLSPSLLASARSAYRGLLRATATTFAGDTPIRNAFRVKIRSEVLTYPSSSDPKQFEEKIKLTREIADVLRKNVVQGVRIEEAQGPGTHDRFQLRITEHTELGSNDTIKNPPPVESSRSARKHAAKNNESDSTPEPQLPRFYSQLKKAAKQHVVPELREEDLEESFVRGSGPGGQSINKTENNVQLLHKPTGLRVACQETRSLAQNRKIARKILRNKLDAMYNPGLSKQEVRKALEQERERRRRRKAKKAKKLQLVDQIVQEAKSRLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JIA9</accession>
    <name>A0A2H3JIA9_WOLCO</name>
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        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
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    <organism evidence="2 3">
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467931">
        <property type="protein sequence ID" value="PCH37468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JIA9"/>
    <dbReference type="OrthoDB" id="2798901at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="432"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="437"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH37468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="451" mass="50884" checksum="4977F00FE9E3F986" modified="2018-01-31" version="1">MDDAVLPIEVCGFIIDELCRDRGTLWACCLVCRTWLPRSRCNLYSSISIDDAKSLDLFHRRIILDPEARKYLNNSRELHLLGPDYGDPDEMYQPSRPEFIYRALLPLATGLGPTVTYLEIRSGSWICTPTMYSPPMQLTQFISVVELALNMCKFGTFSEMQRLIQALPSLARIHLRFIECKRLSITANEYMTPYSNRPRLSTLDIRQCSSAFCNAMFSWLPLTESTQTLSVFEVNDVASLPKGVDSINQSSLGSFLDQVGSSLKYLHVDCLLNADLDLSRSMEWRYSLRLLQTSLNISRDSSAVRRLARILSDAAFNELWVINLAVDIGDISADIDLSQWKDIDDLCSFPKLPTLRAFAIKLTWSGLLDISDESVIDERVGQTISKFRDQLSGIHERGILLVTESVECRMSHFANSFVVDLNDLAELSTFEERSEDSNSGEVSETSSALDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JIY8</accession>
    <name>A0A2H3JIY8_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Indoleamine 2,3-dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WOLCODRAFT_22782</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the indoleamine 2,3-dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH37708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JIY8"/>
    <dbReference type="STRING" id="742152.A0A2H3JIY8"/>
    <dbReference type="OMA" id="SNKIMEP"/>
    <dbReference type="OrthoDB" id="540174at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033754">
        <property type="term" value="F:indoleamine 2,3-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000898">
        <property type="entry name" value="Indolamine_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037217">
        <property type="entry name" value="Trp/Indoleamine_2_3_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657:SF5">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01231">
        <property type="entry name" value="IDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140959">
        <property type="entry name" value="Indolic compounds 2,3-dioxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="381"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="binding site" description="proximal binding residue" evidence="4">
        <location>
            <position position="366"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600898-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PCH37708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="428" mass="48144" checksum="D53DED1D40244921" modified="2018-01-31" version="1">MVRPVRFSPRDYDVDPRTGFFPSEPLPRLPEPYEAWEDTFEAARSVVTLRTDESEDAVRKRAQGERWRESVRRMAVQTTGKLRGDIRWLQRAHMVLASIMHFYVHSLPATEPNVIPKAVAIPLVDVSKALAMAPVLTFADTVLWNWEFIDPTKPLSVDNMRYVNNFSGTEAENNFYLSSAAVELKGVEMLEIFERFMNLRHVTEARLVEIIGGDLTRLSKTVGELTKILNSMKESVDPPTFYFSVRPWWAGSTSDPSRPWVMEGVSGSSAMDLGGASAGQSSVMHALDIFLDIDHKLQTKRVPAPTPNNRQADRGFMERMRRYMPGLHREYLEHLRSVREVVSQHPSLKGPYNDAVMALKCLRDDHIKIVALYVVTKSNATPPPQFRKLSEGDVARPAGPARGTGGSEVSTLLKAGRDATQRALLKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JJ68</accession>
    <name>A0A2H3JJ68_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Mu-adaptin 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">WOLCODRAFT_137482</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the adaptor complexes medium subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468113">
        <property type="protein sequence ID" value="PCH41585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JJ68"/>
    <dbReference type="STRING" id="742152.A0A2H3JJ68"/>
    <dbReference type="OMA" id="INVHFTI"/>
    <dbReference type="OrthoDB" id="870at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030131">
        <property type="term" value="C:clathrin adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09252">
        <property type="entry name" value="AP-3_Mu3_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14837">
        <property type="entry name" value="AP3_Mu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050431">
        <property type="entry name" value="Adaptor_comp_med_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001392">
        <property type="entry name" value="Clathrin_mu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018240">
        <property type="entry name" value="Clathrin_mu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10529">
        <property type="entry name" value="AP COMPLEX SUBUNIT MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005992">
        <property type="entry name" value="Clathrin_mu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00314">
        <property type="entry name" value="CLATHRINADPT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00990">
        <property type="entry name" value="CLAT_ADAPTOR_M_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="6">
        <location>
            <begin position="188"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR005992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PCH41585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="430" mass="47222" checksum="66DF83327ED153EF" modified="2018-01-31" version="1">MAIDGLIILDSAGRPIIQSGFRSSAAAYPLLHIDALNNALENAPRPDDVDPVLHVSSLNVDAPAACCHAKVADMRILCPISGDVDPLYAFAFLQTFVDILREYFGHISAETLKDNFDVVYQLLEETLDSGGHPLTTSPNALRDIVLPPSLLNKVLSVAGVSGLASPSASSHPFASPIPWRKAGVRYNNNEIYFDVTETLEAIVNKNGTPAVSNVWGKVESNCKLSGIPDLLLTFSNSQSLVDCSFHPCVRLQRWSRDKTLSFVPPDGRFKLMEYRFAPVSASSQNQTAVPLMLRSVINVEEHGGSFDVTLTSRLTTRSMESVSVELFLGEGASSASCIASHNASWSFDLKTLSLRWEMKNVSPSASYTLRGTFSSAAQTPRPSRAFRVRFDSMQHTFSALKIDQLKMTGELYKPYKGMRGRSLGDIEWRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JJA2</accession>
    <name>A0A2H3JJA2_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">UFD1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">WOLCODRAFT_15485</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UFD1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH37828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JJA2"/>
    <dbReference type="STRING" id="742152.A0A2H3JJA2"/>
    <dbReference type="OMA" id="VCMIETD"/>
    <dbReference type="OrthoDB" id="422728at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034098">
        <property type="term" value="C:VCP-NPL4-UFD1 AAA ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.50">
        <property type="entry name" value="Ubiquitin fusion degradation protein UFD1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004854">
        <property type="entry name" value="Ufd1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042299">
        <property type="entry name" value="Ufd1-like_Nn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055417">
        <property type="entry name" value="UFD1_N1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055418">
        <property type="entry name" value="UFD1_N2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12555">
        <property type="entry name" value="UBIQUITIN FUSION DEGRADATON PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12555:SF13">
        <property type="entry name" value="UBIQUITIN RECOGNITION FACTOR IN ER-ASSOCIATED DEGRADATION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03152">
        <property type="entry name" value="UFD1_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24842">
        <property type="entry name" value="UFD1_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin fusion degradation protein UFD1 N-terminal subdomain 1" evidence="4">
        <location>
            <begin position="33"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin fusion degradation protein UFD1 N-terminal subdomain 2" evidence="5">
        <location>
            <begin position="133"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="232"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="346"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="234"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="264"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="282"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="355"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="399"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="441"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PCH37828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="456" mass="48186" checksum="77676A73D1900323" modified="2018-01-31" version="1">MDPFGTGPGGLFAHLGFGAGIGHHIRGRPASSYDDYFKAYSVAMLPGKERENVSYGGKIIMPPSALANLTTLELDSPWMFKLRNPANPAASTHAGVLEFIAEEGCVHLPHWMMKTLRLEEGDPIRITGAELPKGKMVKLQAQSTLFLEISDPKAVLEQALRHFSVLTQGDIIEISYNSIVFGLLVMDAQPGGEGISVLDTDLEVDFAAPLGYVEPERPRAAAPSTMASKLNIDLDSQTPGSSRPTSALGGSFPGQSSRVSAVSKDGDHWESFKGKGETLAGRKTKGKGVSHRKIEEAPVESKIIRTDKHRIVTSETLESEVSAPAPLNLPFGKLFFGFNVAPYEPPESDAAGTGRSLNGRSTGQQQPPSDPKGKGREGTASAASWGSGGQTLGGSQPNAAPARSVASSAARAVGAGGAPVPVLPPRNMTPSKQRSLSPEDWGVDDEDVIEIDSDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JJD9</accession>
    <name>A0A2H3JJD9_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">WOLCODRAFT_137837</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Is probably involved in a pathway contributing to genomic integrity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the IRC22 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468124">
        <property type="protein sequence ID" value="PCH42310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JJD9"/>
    <dbReference type="STRING" id="742152.A0A2H3JJD9"/>
    <dbReference type="OMA" id="YQEEWIP"/>
    <dbReference type="OrthoDB" id="1926781at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005595">
        <property type="entry name" value="TRAP_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12924:SF0">
        <property type="entry name" value="TRANSLOCON-ASSOCIATED PROTEIN SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12924">
        <property type="entry name" value="TRANSLOCON-ASSOCIATED PROTEIN, ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03896">
        <property type="entry name" value="TRAP_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0732">Signal</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013742894" evidence="11">
        <location>
            <begin position="23"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="213"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PCH42310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="254" mass="27452" checksum="D9A5482069927835" modified="2018-01-31" version="1">MRLQSLLGYLVGSVALLQSVLAAPEAAAVEPVVLAIATFPEDNAFGHVVNGERNAVFVTVENLSDRNITIKSVAGSFHHPETNALVKNTTSLAYNVPVLAGMKTQLPYGFYSEFKPGDLRLNIWLDHTTDGETYRVTAYDSIISIVEPEISWFDLKTLSTYLIVTLLLGGLGYYAYLTFVPQPKQKTRPAPVVSAPVGTVTATGAGGYQEEWIPEHHLKKSKSRKAQSGAAPSGDETSGTELSGTEGKKRKGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JJJ2</accession>
    <name>A0A2H3JJJ2_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WOLCODRAFT_140245</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="KB467865">
        <property type="protein sequence ID" value="PCH36167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JJJ2"/>
    <dbReference type="STRING" id="742152.A0A2H3JJJ2"/>
    <dbReference type="OMA" id="HTKVTIW"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="3"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PCH36167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="473" mass="52091" checksum="60D2928A59128AEA" modified="2018-01-31" version="1">MFGSACPQQGGSIPDVLPFTIPVQTPNNTVSEDCLFVNVYAPTSAKPGDNLPVVFWIYGGAFETGDSSMYPGTAIVERSIELGEPVIFVSHNYRLNAFGFLASQEVVDAGQTNIGLRDQRFAMQWVQQHISAFGGDPTKVTIWGESAGAWSVGFHLLLNNGDNEGLFRAAIMESGSPYALRNYTAGQPFYDTLLNYTNCSSSADTLACLRHAPYEQLMAAVNATPNGFDYTGQNLAWQPRLDGDLFVRNPQRSMQMGLYAKVAILSGDCDDEGTLFSLGNTNITSDSEFLSYIHSNYIPSATDSAIVNVSKLYPDIPSEGSPFDTGDSNVLTAQYKRIAAFTGDWQFQAPRRLLLSTMSQTQDCWAYLFKRYKTTPYLGTYHSSDLTEFFSDIDFIGTDAIINFANRLNPNASPRLAPNVSYFSNVTWAQWDSNLSSPPLLEFLDPAPRLGFTPDTYRADAMAYLNTLSLQMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JJL8</accession>
    <name>A0A2H3JJL8_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WOLCODRAFT_144015</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the shaker potassium channel beta subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468124">
        <property type="protein sequence ID" value="PCH42372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JJL8"/>
    <dbReference type="STRING" id="742152.A0A2H3JJL8"/>
    <dbReference type="OMA" id="YEHGINM"/>
    <dbReference type="OrthoDB" id="1720422at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005399">
        <property type="entry name" value="K_chnl_volt-dep_bsu_KCNAB-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43150">
        <property type="entry name" value="HYPERKINETIC, ISOFORM M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43150:SF2">
        <property type="entry name" value="HYPERKINETIC, ISOFORM M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="4">
        <location>
            <begin position="48"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PCH42372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="378" mass="41819" checksum="CA1BCBFBF5CC9295" modified="2018-01-31" version="1">MALQTWDVKVEYNAKGMPFRRLGPSGLRVPLFSLGGWLTLGGSVRGDEILKTAFENGINMFDTAEGYAAGRSEEEMGRVIKELGLRRSDIIVTTKLFWSPHERQNGTGLSRKHIVEGTRESLQRLGLDYVDVIFAHRPDNTVPIEETVRAFNFVIDQGWAFYWATSMWSAQEIEEAHHVASKLGLSGPIAEQCRHQYVPHLAARLHMSFNVMQTCSMLSRDRPEGEYAPLYRKYGLGTTVYSALAGGLLTGKYTNGIPSDSRLAVEQEQQVKDLAAFLSTPDGVEMLAKIKTLTDFAENELGCKASHLALAWVAKNPNTSTIILGASKPEQIVDNLKALEVIPKLTPEIMDRIESILANKPAPVPTFGRPALDAYGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JJP5</accession>
    <name>A0A2H3JJP5_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Ubiquitin-related modifier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">URM1</name>
        <name evidence="7" type="ORF">WOLCODRAFT_92181</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by the MOCS3 homolog UBA4. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as AHP1. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 6">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="5">C-terminal thiocarboxylation occurs in 2 steps, it is first acyl-adenylated (-COAMP) via the hesA/moeB/thiF part of UBA4, then thiocarboxylated (-COSH) via the rhodanese domain of UBA4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the URM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB467898">
        <property type="protein sequence ID" value="PCH36894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JJP5"/>
    <dbReference type="STRING" id="742152.A0A2H3JJP5"/>
    <dbReference type="OMA" id="DYELQPN"/>
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                <person name="Barry K."/>
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                <person name="Martinez A.T."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </location>
    </feature>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="342" mass="37580" checksum="5D0F87EF091E9DD9" modified="2018-01-31" version="1">MMSSSATSALPSSTSPSYATDESAEILWYEQSINAAVYIGAMAWGLQVVVYFQALKATLRSPIKGMRLWTLFTSVSFSLTTVNICCNINFNERAWIDEREYPGGPISFFSREQALPVNVASIATSVICMFLTNGLLIYRCHALWNKAYITLFLCATLVACTVMSILHSIQVVHAPSGSWDDTLLSLCVPYASLTMSLNVLLVLILVFRLLDLSRKLPKSLPTQTHKDYTSLEALLIESALPYGTVSFVFSIFFGVRSTIANLFLSLIIQLQGITSGLIVTRMANGHAWSTDLLRSIGPNKITFRGQLGRSPNSDAVADDVSMFALGDEPREQVDVKVPTMFA</sequence>
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    <gene>
        <name evidence="10" type="primary">BNA4</name>
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    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
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                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD-104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>L-kynurenine + NADPH + O2 + H(+) = 3-hydroxy-L-kynurenine + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:20545"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57959"/>
            <dbReference type="ChEBI" id="CHEBI:58125"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.13.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="10">Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the aromatic-ring hydroxylase family. KMO subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.9" evidence="10"/>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH38088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JK11"/>
    <dbReference type="STRING" id="742152.A0A2H3JK11"/>
    <dbReference type="OMA" id="REFMFIA"/>
    <dbReference type="OrthoDB" id="10053569at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00328"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004502">
        <property type="term" value="F:kynurenine 3-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043420">
        <property type="term" value="P:anthranilate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070189">
        <property type="term" value="P:kynurenine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006569">
        <property type="term" value="P:L-tryptophan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019805">
        <property type="term" value="P:quinolinate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000129">
        <property type="entry name" value="Kynurenine 3-monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01971">
        <property type="entry name" value="Kynurenine_monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027545">
        <property type="entry name" value="Kynurenine_monooxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46028">
        <property type="entry name" value="KYNURENINE 3-MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46028:SF2">
        <property type="entry name" value="KYNURENINE 3-MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0274">FAD</keyword>
    <keyword evidence="2 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="7 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 10" id="KW-0521">NADP</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 10" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="471"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="12">
        <location>
            <begin position="10"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PCH38088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="499" mass="56083" checksum="15757422E91CBB2B" modified="2018-01-31" version="1">MSGTEHSRRKAIIVGAGPVGCLSAISLAKMGWAVEIYEGRPDMRLPSSKAAAQQRSINLAMSARGIAAIEAIEPNAADRFLKAVIPMHGRMIHHVEGRQESQPYDRDGQCINSIGRSFLNEDLLTEALRIPNIRVFFRHKVSSIDFDGRIMSIHDLDAEKDIEVLFDFCVGSDGSYSIVRRQLMRVVRMDYQQEYIPHDYLELKMPAGPAVDIGGDPTYLLDPNHLHIWPRHTFMLIALPNKDKTFTCTLFAPTTEFDRLDADETIIKWFKTHFPDALLLIGEEALLYAFRNNPRSSLMSIKANPYHYKDRAILLGDAAHAMVPFYGQGLNCGLEDVRVLDILLRAEGVNPTDLVTGEDKRLAKALDRYTETRHDDLVSICELAMANYVEMRHDVVTPGYLFKKTIDNILYSLTSKAAGASSIMPALVRDPFPTSSPSGWIPQYTMVTFRPDISYSTVRRVAARQRRILDYTSWASAAVGVGMVGITAITIWRRFFNRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JK76</accession>
    <name>A0A2H3JK76_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GTP-binding protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_137625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468124">
        <property type="protein sequence ID" value="PCH41945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JK76"/>
    <dbReference type="STRING" id="742152.A0A2H3JK76"/>
    <dbReference type="OMA" id="EHHITIE"/>
    <dbReference type="OrthoDB" id="248233at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050055">
        <property type="entry name" value="EF-Tu_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721">
        <property type="entry name" value="ELONGATION FACTOR TU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721:SF9">
        <property type="entry name" value="GTP-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH41945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="455" mass="49517" checksum="83C986346C3F6AC4" modified="2018-01-31" version="1">MFGEHDSESPRVPSPWDPFLPSPPSSLEANKQFYNGIPKLVPEVEEGNVEYKLKLTHISPARFARLVTQLKWRLLEGGGQAYYELGVADSGALVGLSRADLEQSLATLDTMAGEIGASVIVVKEIEVPHAMVALAEESGMYLDPDTGGWARKMRKGVPILSEDESATETTETEPETEFSTADSTDVDDVQTSNSNWPHAPSVPRSASFAHRLTSHPARPSAQSSPYIAPLDDDLALFSMEPEPSHLTTDTDSDITLVTTPPDASAFSIDLEIASVYKPRPARRRTQAAGALFAVPFTGKHARRQKYKEKQKQQPWHAMSNAAAAIESKEALTKEAKAMHRRIARDQRREEKRKAYLDSAVASDVPAETEELAHALDALHVTVESTNPVGLGAQTLSKSPQLDVVPSNMEEAQASAGATGTNDKAAREPRLIVEALVVRKMSIEEAFLDFGGFQLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JKH2</accession>
    <name>A0A2H3JKH2_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">WOLCODRAFT_163979</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468124">
        <property type="protein sequence ID" value="PCH42696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JKH2"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PCH42696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="239" mass="25615" checksum="7186D40E1A4C46C0" modified="2018-01-31" version="1">MRLAQRAGSCDVLRSDLATHVSALPVLSGSAAAIASLRPRGACAPRELRTITTALLLRSVCAYVTQPPALVPFQWMIPAHCRTRFEQSPCPPDRMSFQIRMLSRHAFATPRDDIPWNIGSRGEGASERSSFAPAPDQIAFGDTLPNGTAFPSDSRIPSTGEKLNDGIVDRISADAHAVPVSSPEANIVTRLGLGTPAVSDVLSLMYAGKWATGAVRWRLARPGDPQKCQGTDREGVSRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JKW5</accession>
    <name>A0A2H3JKW5_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WOLCODRAFT_25413</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD-104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="KB468124">
        <property type="protein sequence ID" value="PCH42511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JKW5"/>
    <dbReference type="STRING" id="742152.A0A2H3JKW5"/>
    <dbReference type="OMA" id="QMARVGE"/>
    <dbReference type="OrthoDB" id="5800476at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14127">
        <property type="entry name" value="STKc_CK1_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000160">
        <property type="entry name" value="Casein kinase I 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000538">
        <property type="entry name" value="Putative Casein kinase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="29"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="335"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="343"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="361"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="388"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="468"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="482"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PCH42511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="549" mass="60508" checksum="16DDC0B26D7E9AAE" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JL58</accession>
    <name>A0A2H3JL58_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">WOLCODRAFT_167452</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467931">
        <property type="protein sequence ID" value="PCH37384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JL58"/>
    <dbReference type="STRING" id="742152.A0A2H3JL58"/>
    <dbReference type="OrthoDB" id="430315at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.110.10">
        <property type="entry name" value="Thaumatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037176">
        <property type="entry name" value="Osmotin/thaumatin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001938">
        <property type="entry name" value="Thaumatin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31048">
        <property type="entry name" value="OS03G0233200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00314">
        <property type="entry name" value="Thaumatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00205">
        <property type="entry name" value="THN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49870">
        <property type="entry name" value="Osmotin, thaumatin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51367">
        <property type="entry name" value="THAUMATIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH37384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="451" mass="47466" checksum="6932C0A59E6491BE" modified="2018-01-31" version="1">MAVRGGTDVRADVHCGERMPVHDMVSGTRSTPGQALLMQVYVQACLLDYPAGLLYTRAMDRARHADEPSWETQPHTSIAVHGAAPIATLATTAPAASWCTGGLLCNPTTGTVSTCLIICVGTLSTYPALQGVSPATVAEWTLQGSAATFAHEEPLAFILCLASLIGGFNIPMEITNNPKCSIAECPVDPNSLCPGALNGPRSSTGGAVDCQSSCDARLNGDKTNSPDCYTGSSFKGNCPDSYAYAFDEWGGRRCGSCDVSDTGTARHASPAALLRQMRQRREERWLHSKRTAQHDCGRSERSPRRWSPASDTVAICQRSLSRVESGDDRGAPAVRISPSRCDGCLSGPQMPSARQRNALVGMSVSVGCLSGFEIAHCTGLPIDLAVDRLASAVGRDYDILVGTTPFSTGEAMNQGLEIAAHQAGADLSGSLLVDTSFGDSSYQKGRAVFSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JLF2</accession>
    <name>A0A2H3JLF2_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">WOLCODRAFT_138172</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">MD-104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468135">
        <property type="protein sequence ID" value="PCH43036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JLF2"/>
    <dbReference type="STRING" id="742152.A0A2H3JLF2"/>
    <dbReference type="OMA" id="GNLRMYI"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00029">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13999">
        <property type="entry name" value="STKc_MAP3K-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050940">
        <property type="entry name" value="Actin_reg-Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46485:SF5">
        <property type="entry name" value="CENTER DIVIDER, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46485">
        <property type="entry name" value="LIM DOMAIN KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="20"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="12">
        <location>
            <begin position="512"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="308"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="361"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="573"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="361"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="400"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PCH43036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="593" mass="64570" checksum="86EDEC1A940DA10C" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JLZ8</accession>
    <name>A0A2H3JLZ8_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GATA-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">WOLCODRAFT_25804</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB468135">
        <property type="protein sequence ID" value="PCH43226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JLZ8"/>
    <dbReference type="STRING" id="742152.A0A2H3JLZ8"/>
    <dbReference type="OMA" id="TIHRMQF"/>
    <dbReference type="OrthoDB" id="515401at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000007">
        <property type="entry name" value="Nitrogen regulatory AreA, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013860">
        <property type="entry name" value="AreA_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039355">
        <property type="entry name" value="Transcription_factor_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071:SF281">
        <property type="entry name" value="BOX A-BINDING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071">
        <property type="entry name" value="TRANSCRIPTION FACTOR GATA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08550">
        <property type="entry name" value="GATA_AreA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00619">
        <property type="entry name" value="GATAZNFINGER"/>
    </dbReference>
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        </location>
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        </location>
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            <begin position="152"/>
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            <begin position="212"/>
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        <source>
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    </evidence>
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        <source>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JN96</accession>
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        <submittedName>
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        <name evidence="6" type="ORF">WOLCODRAFT_74699</name>
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        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
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        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
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                <person name="St John F."/>
                <person name="Stenlid J."/>
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                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
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                <person name="Martin F."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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    <accession>A0A2H3JNC9</accession>
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            <fullName evidence="7">Uncharacterized protein</fullName>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Martinez A.T."/>
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                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
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                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
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                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
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                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
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                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
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                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
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                <person name="Schmutz J."/>
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                <person name="Sun S."/>
                <person name="Syed K."/>
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                <person name="Wiebenga A."/>
                <person name="Young D."/>
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                <person name="Eastwood D.C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
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        </location>
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        <location>
            <begin position="201"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="274"/>
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        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PCH40309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="325" mass="35448" checksum="BBD90D231B5025FB" modified="2018-01-31" version="1">MLWGKTPAIRAPDQDGQDAKAPKATGHPSPYAHPAGPLRQRQRSCTSGRPYGKGNRPSRTDTAASHSHKPPSVSNAKAGTGVSSPRQPAAHQVERQRRLPKQPRHPFRRPRPNRTRSRHAARQRGSPGGGHCENTTLGPTACRTNGNDQAPRTGQSPPSKAYPGTPQQAYQRSGNATASPVHSDTAHGRLHQTHKAPPPQECRELAQQRDAKPRVPRQGTHKGRGGDYNNLPPSNHLNELKNAAQRSRLKTHRQTAIDTPGQRRRHRLSSKDGGQGDKSSEGQKEKSEKTHLWELKAHVGLGQPRTRHHAQSGRSGHPSVTVPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JNW9</accession>
    <name>A0A2H3JNW9_WOLCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">WOLCODRAFT_65071</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB467942">
        <property type="protein sequence ID" value="PCH38334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JNW9"/>
    <dbReference type="STRING" id="742152.A0A2H3JNW9"/>
    <dbReference type="OMA" id="FNYANEI"/>
    <dbReference type="OrthoDB" id="448399at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06133">
        <property type="entry name" value="ERI-1_3'hExo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051274">
        <property type="entry name" value="3-5_Exoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047201">
        <property type="entry name" value="ERI-1_3'hExo-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23044">
        <property type="entry name" value="3'-5' EXONUCLEASE ERI1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23044:SF61">
        <property type="entry name" value="3'-5' EXORIBONUCLEASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="4">
        <location>
            <begin position="11"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PCH38334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="263" mass="30060" checksum="BA11C94D0B2E6674" modified="2018-01-31" version="1">MRQGTKQPYEAFLVLDVEGTCVEGNTSFSYPNEIIEWPVCLLRWADKDKDGKAKVLQVVAEFRSFVKPTWRPLLSQFCTNLTGITQDQVDRAPVFTELCESFKVFLEDNGLIDPGTGQRLVKYCWCSDGPYDVRDFVVKQCFISKVPMPAWITGDVLDVRSEVRALLDAETSRKPQERKRSASAYAFPVNPRMVLTIPRQLQALGLSPFEGRHHSGIDDTRNIARILIELARRGVRLMPNTSINPKRRWPWMGKRGKILDGYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JP06</accession>
    <name>A0A2H3JP06_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Peptide transporter MTD1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">WOLCODRAFT_26301</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">MD-104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="KB468146">
        <property type="protein sequence ID" value="PCH43920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JP06"/>
    <dbReference type="OMA" id="LYKRYRW"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="227"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="261"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="343"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="468"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="494"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="578"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="645"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="722"/>
            <end position="745"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PCH43920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="776" mass="86640" checksum="4DB51B9635367896" modified="2018-01-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JQM1</accession>
    <name>A0A2H3JQM1_WOLCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FMN-linked oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">WOLCODRAFT_76332</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Wolfiporia cocos (strain MD-104)</name>
        <name type="common">Brown rot fungus</name>
        <dbReference type="NCBI Taxonomy" id="742152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Phaeolaceae</taxon>
            <taxon>Wolfiporia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
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                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
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                <person name="Martin F."/>
                <person name="Cullen D."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">MD-104</strain>
        </source>
    </reference>
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        <cofactor evidence="1">
            <name>FMN</name>
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        </cofactor>
    </comment>
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        <property type="protein sequence ID" value="PCH44436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:NADPH dehydrogenase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="OYE_YqiM_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044152">
        <property type="entry name" value="YqjM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43303">
        <property type="entry name" value="NADPH DEHYDROGENASE C23G7.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NADPH DEHYDROGENASE C23G7.10C-RELATED"/>
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    </dbReference>
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        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FMN-linked oxidoreductases"/>
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    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PCH44436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="411" mass="44747" checksum="7ED395FD22913FDC" modified="2018-01-31" version="1">MEDIVSPAAANTSYFTPAQEPPAGTALYPQPDGKPIPKLFRPITIRGVHFQNRIMLSPLGQSSANNGSLTPWHSAHLGGILIYGPGLTFIEATAVLPEGRTSPEDSGLWDDSQIESLRKLVEFAHSQNQKIGMQLGHAGRKASTVAKWLAAENGASEAVGGWPNDVVAPSPIPYKNSPDYPKPEPLNETGIKRVVKAFADAAVRAVKAGVDVIDIHGAHGYLLHQFMSPVSNKRQDKYGGSFENRIRLALEVVDAVRAVIPADVPLMFRPSATDWLEEVAPDEPSWRCEDTVNLAEILIDHGVDLIDVSSAGLDSRQKIKFIAPAYQAHFAEAVKKRVGDRMLVASVGGIKDGIIAQKVLEKQGIDMVLVGRQFLRDHQSVWTFAEQLGVTVQLPNQANWVFRGRGSARRK</sequence>
</entry>
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    <accession>A0A2H3JQM3</accession>
    <name>A0A2H3JQM3_WOLCO</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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        <name evidence="2" type="ORF">WOLCODRAFT_138845</name>
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        <lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
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                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
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                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
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                <person name="Stenlid J."/>
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                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
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            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH44231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="326" mass="35905" checksum="19A43B8334002EBF" modified="2018-01-31" version="1">MTQLPIISVNLATVALESLFYGIFLVLAGTSMYLHLGRAESQASHGNKLSAYFTPVILGSVWITLTVTGHWILTVTRLFDAFVNFMGGQEAMLYYMDLALTTEVVKTAFLIATLIVSDVLFIYRLWTVWNYNYYVIVLPICTVLGLCVAGPGVIYQLTRVAAGGTVFVSQLNRWISADYAFTFTTNVYSSCGIAWRVWRARQRSGSRYGGGNLMRVLATIVESAAIYTSYTIFFFGSYQASSNLQYTAVDTLCPVAGIAFMMINVRVGLGWAQNAHPSAASSGAITSRRTVEQSFAMRPVAVDISQVVQKEDDMGHPIKSDFKEPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
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    <name>A0A2H3JR32_WOLCO</name>
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            <fullName evidence="2">Prokaryotic-type class I peptide chain release factors domain-containing protein</fullName>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
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                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
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                <person name="Lucas S."/>
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                <person name="Martin R."/>
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                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
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                <person name="Schmutz J."/>
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                <person name="St John F."/>
                <person name="Stenlid J."/>
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                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11075:SF54">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11075">
        <property type="entry name" value="PEPTIDE CHAIN RELEASE FACTOR"/>
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    </dbReference>
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        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110916">
        <property type="entry name" value="Peptidyl-tRNA hydrolase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="62"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH42353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
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            <taxon>Agaricomycetes</taxon>
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            <taxon>Phaeolaceae</taxon>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D.S."/>
            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">MD-104</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="PCH44642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JR61"/>
    <dbReference type="OMA" id="NGALHCA"/>
    <dbReference type="OrthoDB" id="5346979at2759"/>
    <dbReference type="Proteomes" id="UP000218811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="150"/>
            <end position="175"/>
        </location>
    </feature>
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        <location>
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            <end position="23"/>
        </location>
    </feature>
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        <location>
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    </feature>
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    </feature>
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        <location>
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            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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            <end position="131"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PCH44642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="285" mass="30259" checksum="10BF6C980AFA6E21" modified="2018-01-31" version="1">MSGSNKLENAALQNAPNESSSEYKPFFGLDSAKRADVPRWVPVSLLALTTAAMVVPAILLRRQRAALLDKSLSHTPPPPPRRSSGTLPPLSPSSGISSSSNNAPPPRRVPVVASRNPVPSPARAAIRAHPAAVAETEASKAADDSNFNGALLSAGAFGIATAIVSVGAGLTLWGVKTSLGVSNAQEFADRVRALIIERMPLLSSRIHRRIQREDETSELRLGPPTTPSSHIHVEPASGAAEWTWHDAEKRLKAAFQQDGIVGWAEAALQELEAEGELERAKRGHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
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    <name>A0A2H3JR88_WOLCO</name>
    <protein>
        <submittedName>
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        </submittedName>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
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                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
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                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
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                <person name="Stenlid J."/>
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                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB468168">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2H3JR88"/>
    <dbReference type="STRING" id="742152.A0A2H3JR88"/>
    <dbReference type="OMA" id="DMYIYER"/>
    <dbReference type="OrthoDB" id="3255922at2759"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
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        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH44666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="520" mass="56254" checksum="B9CE109CE4B1ED51" modified="2018-01-31" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JRD2</accession>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
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                <person name="Riley R."/>
                <person name="Barry K."/>
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                <person name="Otillar R."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">MD-104</strain>
        </source>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="7"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PCH44712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000218811"/>
        </source>
    </evidence>
    <sequence length="214" mass="23993" checksum="931A4E72B2246DAA" modified="2018-01-31" version="1">MDQLLTIQQLPPEIWIIVLSYLINDQETLKKCGLVCHAWLSAARPHLLRTVRIRNISRVLEIDTSIDTFPDIARYIRKLHVGPIGWTGTPPCHKEQQEMWQCSLRLLGKLKGTREVLIDLIGGRIDLVPDDMQGQLSALLEGVEILALSGFVCLGGPPALQCILLACSRLSHLYLNGVCFADDVAPYHLHDATANHKETLRTFVYYGDDDDPSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
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            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Phaeolaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
            <authorList>
                <person name="Floudas D."/>
                <person name="Binder M."/>
                <person name="Riley R."/>
                <person name="Barry K."/>
                <person name="Blanchette R.A."/>
                <person name="Henrissat B."/>
                <person name="Martinez A.T."/>
                <person name="Otillar R."/>
                <person name="Spatafora J.W."/>
                <person name="Yadav J.S."/>
                <person name="Aerts A."/>
                <person name="Benoit I."/>
                <person name="Boyd A."/>
                <person name="Carlson A."/>
                <person name="Copeland A."/>
                <person name="Coutinho P.M."/>
                <person name="de Vries R.P."/>
                <person name="Ferreira P."/>
                <person name="Findley K."/>
                <person name="Foster B."/>
                <person name="Gaskell J."/>
                <person name="Glotzer D."/>
                <person name="Gorecki P."/>
                <person name="Heitman J."/>
                <person name="Hesse C."/>
                <person name="Hori C."/>
                <person name="Igarashi K."/>
                <person name="Jurgens J.A."/>
                <person name="Kallen N."/>
                <person name="Kersten P."/>
                <person name="Kohler A."/>
                <person name="Kuees U."/>
                <person name="Kumar T.K.A."/>
                <person name="Kuo A."/>
                <person name="LaButti K."/>
                <person name="Larrondo L.F."/>
                <person name="Lindquist E."/>
                <person name="Ling A."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lundell T."/>
                <person name="Martin R."/>
                <person name="McLaughlin D.J."/>
                <person name="Morgenstern I."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Nagy L.G."/>
                <person name="Nolan M."/>
                <person name="Ohm R.A."/>
                <person name="Patyshakuliyeva A."/>
                <person name="Rokas A."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Sabat G."/>
                <person name="Salamov A."/>
                <person name="Samejima M."/>
                <person name="Schmutz J."/>
                <person name="Slot J.C."/>
                <person name="St John F."/>
                <person name="Stenlid J."/>
                <person name="Sun H."/>
                <person name="Sun S."/>
                <person name="Syed K."/>
                <person name="Tsang A."/>
                <person name="Wiebenga A."/>
                <person name="Young D."/>
                <person name="Pisabarro A."/>
                <person name="Eastwood D.C."/>
                <person name="Martin F."/>
                <person name="Cullen D."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22745431"/>
            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">MD-104</strain>
        </source>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
            <title>The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes.</title>
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                <person name="Barry K."/>
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            <dbReference type="DOI" id="10.1126/science.1221748"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">MD-104</strain>
        </source>
    </reference>
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    </dbReference>
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    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2H3JS73</accession>
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        <citation type="journal article" date="2012" name="Science" volume="336" first="1715" last="1719">
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4 5">MD-104</strain>
        </source>
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    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
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        <location>
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